MCID: DBT031
MIFTS: 36

Diabetes, Type 2 malady

Summaries for Diabetes, Type 2

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Diabetes means your blood glucose, or blood sugar, levels are too high. with type 2 diabetes, the more common type, your body does not make or use insulin well. insulin is a hormone that helps glucose get into your cells to give them energy. without insulin, too much glucose stays in your blood. over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. you have a higher risk of type 2 diabetes if you are older, obese, have a family history of diabetes, or do not exercise. the symptoms of type 2 diabetes appear slowly. some people do not notice symptoms at all. the symptoms can include being very thirsty urinating often feeling very hungry or tired losing weight without trying having sores that heal slowly having blurry eyesight a blood test can show if you have diabetes. many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. some people also need to take diabetes medicines. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes, Type 2, also known as diabetes mellitus, non-insulin-dependent, is related to type 2 diabetes mellitus and maturity-onset diabetes of the young. An important gene associated with Diabetes, Type 2 is GPD2 (glycerol-3-phosphate dehydrogenase 2 (mitochondrial)). The drugs acetohexamide and chlorpropamide and the compound glycerol 3-phosphate have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and heart, and related mouse phenotype adipose tissue.

Wikipedia:64 Diabetes mellitus type more...

Description from OMIM:47 125853

Aliases & Classifications for Diabetes, Type 2

Sources:
47OMIM, 34MedlinePlus, 61UMLS
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Aliases & Descriptions:

diabetes, type 2 47
diabetes mellitus, non-insulin-dependent 61
diabetes type 2 34


Related Diseases for Diabetes, Type 2

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Diabetes, Type 2:



Diseases related to diabetes, type 2

Clinical Features for Diabetes, Type 2

Sources:
47OMIM
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Clinical features from OMIM:

125853

Clinical synopsis from OMIM:

125853

Drugs & Therapeutics for Diabetes, Type 2

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Diabetes, Type 2

Anatomical Context for Diabetes, Type 2

Sources:
33MalaCards
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MalaCards organs/tissues related to Diabetes, Type 2:

33
Liver, Kidney, Heart, Pancreas, Thyroid, Monocytes, T cells, B cells, Endothelial, Fetal liver, Fetal thyroid, Pancreatic islet

Animal Models for Diabetes, Type 2 or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Diabetes, Type 2:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0GPD2, PPARG

Publications for Diabetes, Type 2

Sources:
51PubMed
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Articles related to Diabetes, Type 2:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Monocyte chemoattractant protein-1 -2518G/A gene polymorphism and the risk of nephropathy in type 2 diabetes mellitus among Asians: a meta-analysis. (24059294)
2014
2
Re: "Prevalence of Diagnosed and Undiagnosed Type 2 Diabetes Mellitus Among US Adolescents: Results From the Continuous NHANES, 1999-2010". (24243743)
2014
3
Incidence of type 1 diabetes in Norway among children aged 0-14 years between 1989 and 2012: has the incidence stopped rising? Results from the Norwegian Childhood Diabetes Registry. (24149838)
2014
4
Antibodies to influenza virus A/H1N1 hemagglutinin in type 1 diabetes children diagnosed before, during and after the Swedish A(H1N1)pdm09 vaccination campaign 2009-2010. (24313339)
2013
5
Letter: diabetic retinopathy and endothelial dysfunction in patients with type 2 diabetes mellitus (diabetes metab j 2013;37:262-9). (24199169)
2013
6
Ambulatory Treatment of Type 2 Diabetes Mellitus in the United States, 1997-2012. (24198301)
2013
7
Comment on: Wolpert et al. Dietary fat acutely increases glucose concentrations and insulin requirements in patients with type 1 diabetes: implications for carbohydrate-based bolus dose calculation and intensive diabetes management. Diabetes Care 2013;36:810-816. (24265380)
2013
8
Association between resistin +299A/A genotype and nonalcoholic fatty liver disease in Chinese patients with type 2 diabetes mellitus. (23954219)
2013
9
Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes. (24029427)
2013
10
Comment on: Tsiakou et al. Arterial stiffness is inversely related to plasma adiponectin levels in young normotensive patients with type 1 diabetes. Diabetes Care 2013;36:734-736. (24065859)
2013
11
Management of cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: 2002-2012 literature review. (24219205)
2013
12
Association of monocyte chemoattractant protein-1 (MCP-1) 2518A/G polymorphism with proliferative diabetic retinopathy in Korean type 2 diabetes. (23549806)
2013
13
Vaccination and risk of type 1 diabetes mellitus in active component U.S. Military, 2002-2008. (22075092)
2012
14
Outcome of pregnancy in type 1 diabetes mellitus (T1DMP): results from combined diabetes-obstetrical clinics in Dublin in three university teaching hospitals (1995-2006). (22057636)
2012
15
Comment on: Inzucchi et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-1379. (22996185)
2012
16
Type 1 diabetes mellitus in 2011: Heterogeneity of T1DM raises questions for therapy. (22183128)
2012
17
Association of 2238T>C polymorphism of the atrial natriuretic peptide gene with coronary artery disease in Afro-Caribbeans with type 2 diabetes. (22170009)
2012
18
Letter: a retrospective study on the efficacy of a ten-milligram dosage of atorvastatin for treatment of hypercholesterolemia in type 2 diabetes mellitus patients (korean diabetes j 2010;34:359-67). (21537418)
2011
19
Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis. (21638131)
2011
20
Response: a retrospective study on the efficacy of a ten-milligram dosage of atorvastatin for treatment of hypercholesterolemia in type 2 diabetes mellitus patients (korean diabetes j 2010;34:359-67). (21537419)
2011
21
Type 1 diabetes caused by interferon alpha-2alpha in polycythemia vera therapy. (20980420)
2010
22
Genetic evaluation of the TNF-I+ -238G>A and -308G>A promoter polymorphisms in Croatian patients with type I diabetes. (20849900)
2010
23
Comment on: Villareal et al. (2009) TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes;59:479-485. (20508220)
2010
24
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. (20418489)
2010
25
The influence of metabolic parameters on fetal development weight in women with type 1 diabetes and homozygotic variant in -2548 G/A of leptin gene and its 668 A/G receptor polymorphism]. (20873117)
2010
26
Monocyte chemoattractant protein-1 (MCP-1) 2518G/A gene polymorphism in Turkish type 2 diabetes patients with nephropathy. (20960176)
2010
27
MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes. (19781803)
2009
28
Comment on "Lw fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus (pancreas. 2008;36:274-278)". (19390407)
2009
29
Association of the hepatic lipase gene -250G/A promoter polymorphism with the susceptibility to type 2 diabetes mellitus combining with coronary heart disease]. (19350521)
2009
30
An analysis of the prevalence of thyroid autoantibodies: thyroid peroxidase antibodies (ATA) and thyroglobulin antibodies (ATG) in children with newly diagnosed diabetes mellitus type 1 during 2000-2004 in the Upper Silesia region, Poland. (17932620)
2008
31
A Meta-analysis on the association between adiponectin gene 45T/G/276G/T polymorphisms and type 2 diabetes in Chinese population]. (19173941)
2008
32
Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians. (19046302)
2008
33
Association of the chromosomal region 2q35 with type 1 diabetes mellitus in the Russian patients from Moscow]. (18619042)
2008
34
Comment on: Lin et al. (2007) SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes: Diabetes 56: 1177-1180. (17660269)
2007
35
Diabetic retinopathy epidemiology in type II diabetic patients. Effect of the changes in the diagnostic criteria and stricter control of the diabetes between 1993 and 2005 on the incidence of diabetic retinopathy]. (17443425)
2007
36
No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations. (17000021)
2007
37
The TNF-alpha-238G > a single-nucleotide polymorphism protects against memory decline in older adults with type 2 diabetes. (17592954)
2007
38
Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese. (16955255)
2006
39
Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes. (16978381)
2006
40
Relationship between polymorphisms 804C/A and 252A/G of lymphotoxin-alpha gene and -308G/A of tumor necrosis factor alpha gene and diabetic retinopathy in Japanese patients with type 2 diabetes mellitus. (16979413)
2006
41
Relationship between common functional polymorphisms of the p22phox gene (-930A > G and +242C > T) and nephropathy as a result of Type 2 diabetes in a Chinese population. (16922713)
2006
42
Comment on: Biason-Lauber A, Boehm B, Lang-Muritano M, et al (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900-905. (16362282)
2006
43
Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc. (16518702)
2005
44
Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002. (16186395)
2005
45
The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. (15656877)
2005
46
Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus. (15349727)
2004
47
-to: Nicoletti F, Conget L, Di Mauro M et al. (2002) Serum concentrations of the interferon-alpha-inducible chemokine IP-10/CXCL10 are augmented in both newly-diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease. Diabetologia 45:1107-1110. (12819903)
2003
48
A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13. (12727978)
2003
49
Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives. (10330299)
1999
50
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. (8817351)
1996

Genetic Variations for Diabetes, Type 2

Sources:
63UniProtKB/Swiss-Prot
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Genetic disease variations for Diabetes, Type 2:

63 (show all 11)
id Symbol AA change Variation SNP ID
1p.Arg274HisVAR_067310
2p.Ser465ArgVAR_017665
3p.Val402IleVAR_004670rs137853337
4p.Arg1191GlnVAR_004098
5p.Thr858AlaVAR_015917rs182552223
6p.Arg1158GlnVAR_015927
7p.Ser1043TyrVAR_005302
8p.Cys1095TyrVAR_005303
9p.Ser59AsnVAR_012243
10p.Ala931GluVAR_019699rs35449651
11p.Val383IleVAR_007170rs121434581

Expression for genes affiliated with Diabetes, Type 2

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes, Type 2

Search GEO for disease gene expression data for Diabetes, Type 2.

Pathways for genes affiliated with Diabetes, Type 2

Compounds for genes affiliated with Diabetes, Type 2

Sources:
45Novoseek, 24HMDB
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Compounds related to Diabetes, Type 2 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glycerol 3-phosphate45 2410.0GPD2, PPARG

GO Terms for genes affiliated with Diabetes, Type 2

Products for genes affiliated with Diabetes, Type 2

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  • Lysates
  • Antibodies

Sources for Diabetes, Type 2

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet