MCID: DBT031
MIFTS: 61

Diabetes, Type 2 malady

Genetic diseases (common) category
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Summaries for Diabetes, Type 2

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34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Diabetes means your blood glucose, or blood sugar, levels are too high. with type 2 diabetes, the more common type, your body does not make or use insulin well. insulin is a hormone that helps glucose get into your cells to give them energy. without insulin, too much glucose stays in your blood. over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. you have a higher risk of type 2 diabetes if you are older, obese, have a family history of diabetes, or do not exercise. having prediabetes also increases your risk. prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. the symptoms of type 2 diabetes appear slowly. some people do not notice symptoms at all. the symptoms can include being very thirsty urinating often feeling very hungry or tired losing weight without trying having sores that heal slowly having blurry eyesight a blood test can show if you have diabetes. many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. some people also need to take diabetes medicines. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diabetes, Type 2, also known as diabetes mellitus, non-insulin-dependent, is related to obesity and acanthosis nigricans. An important gene associated with Diabetes, Type 2 is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are TGF-beta Signaling Pathways and Transcription Transcription factor Tubby signaling pathways. The drugs acetohexamide and chlorpropamide and the compounds vanadium and vanadyl sulfate have been mentioned in the context of this disorder. Affiliated tissues include heart, eye and kidney, and related mouse phenotypes are renal/urinary system and reproductive system.

Wikipedia:65 Diabetes mellitus type more...

Description from OMIM:47 125853

Aliases & Classifications for Diabetes, Type 2

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47OMIM, 62UMLS, 34MedlinePlus
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Aliases & Descriptions:

diabetes, type 2 47
diabetes mellitus, non-insulin-dependent 62
diabetes type 2 34


Related Diseases for Diabetes, Type 2

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17GeneCards, 18GeneDecks
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Diseases related to Diabetes, Type 2 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.1PPARG, INS, INSR, IRS1, IL18, HNF4A
2acanthosis nigricans30.1INSR, INS
3diabetic retinopathy30.0AGTR1, INSR, INS
4ischemia30.0INSR, MAPK8IP1, CST3, SLC2A4
5proteinuria30.0AGTR1, CST3, INS
6gestational diabetes30.0INS, INSR, IRS1, HNF4A, SLC2A4
7hypertension29.9AGTR1, CST3, INSR, INS, PPARG
8coronary artery disease29.8INS, IRS1, IL18, CST3, AGTR1
9atherosclerosis29.7PPARG, INS, IRS1, IL18, CST3, HNF4A
10insulin resistance29.5AGTR1, PPARG, PPP1R3A, INS, INSR, IRS1
11type 2 diabetes mellitus10.1GPD2
12insulin resistance, severe, digenic10.1PPP1R3A, PPARG
13fetal macrosomia10.1INS
14hyperinsulinemic hypoglycemia10.1INS
15prediabetes syndrome10.1PPARG, INS
16familial partial lipodystrophy10.1PPARG, INS
17papillary thyroid carcinoma10.1PPARG, HNF1B
18conn's syndrome10.1AGTR1, INSR
19rabson-mendenhall syndrome10.1INS, INSR
20donohue syndrome10.1INS, INSR
21neonatal diabetes mellitus10.1HNF1B, INS
22idiopathic edema10.1INS, PPARG
23morbid obesity10.1INS
24congenital generalized lipodystrophy type 210.0INSR, INS, PPARG
25maturity-onset diabetes of the young10.0INS, HNF1B, HNF4A
26hyperandrogenism10.0PPARG, INS, INSR
27choriocarcinoma10.0PPARG, IRS1, HNF4A
28cholestasis10.0HNF1B, HNF4A, NR1H2
29metabolic syndrome x10.0PPARG, INS, SLC2A4
30polycystic ovary syndrome10.0IRS1, INSR, INS
31hepatoblastoma10.0INSR, HNF4A, NR1H2
32liver cirrhosis10.0INSR, IRS1, SLC2A4
33familial hyperlipidemia10.0PPARG, INS, AGTR1
34hyperinsulinism10.0IRS1, INSR, INS, PPARG
35insulinoma10.0HNF4A, INSR, INS, GPD2
36type 1 diabetes mellitus10.0HNF4A, INS
37hypercholesterolemia10.0AGTR1, INSR, INS
38glucose intolerance10.0PPARG, INS, INSR, SLC2A4
39dementia10.0AGTR1, CST3, INSR
40cholera10.0INS, INSR, SLC2A4
41ovarian cancer10.0INSR, AKT2, HNF1B, HNF4A, SLC2A4
42hypoglycemia10.0INS, INSR, HNF4A, SLC2A4
43retinoblastoma10.0PPARG, INSR, IRS1, NR1H2
44diabetes mellitus, noninsulin-dependent10.0IRS1, MAPK8IP1, HNF1B, HNF4A, SLC2A4
45familial combined hyperlipidemia10.0NR1H2, INS
46hyperuricemia10.0HNF1B, INS
47congenital heart disease10.0AGTR1, NR1H2, CST3
48artery disease10.0
49pancreatic carcinoma, somatic10.0
50endotheliitis10.0

Graphical network of the top 20 diseases related to Diabetes, Type 2:



Diseases related to diabetes, type 2

Symptoms for Diabetes, Type 2

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47OMIM
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Symptoms by clinical synopsis from OMIM:

125853

Clinical features from OMIM:

125853

Drugs & Therapeutics for Diabetes, Type 2

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Diabetes, Type 2

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Anatomical Context for Diabetes, Type 2

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33MalaCards
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MalaCards organs/tissues related to Diabetes, Type 2:

33
Heart, Eye, Kidney, Testes, Adipocyte, Endothelial

Animal Models for Diabetes, Type 2 or affiliated genes

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37MGI
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Publications for Diabetes, Type 2

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52PubMed
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Articles related to Diabetes, Type 2:

(show all 20)
idTitleAuthorsYear
1
Immune Mechanisms in Atherosclerosis, Especially in Diabetes Type 2. (24194733)
2013
2
Circulating levels of IL-18 are significantly influenced by the IL-18 +183 A/G polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an observational study. (22141572)
2011
3
Genotypic interactions of renin-angiotensin system genes with diabetes type 2 in a Tunisian population. (20580725)
2010
4
A comparison of physical activity-related social-cognitive factors between those with type 1 diabetes, type 2 diabetes and diabetes free adults. (19844832)
2009
5
Effects of aggressive approach to the multiple risk factors for diabetic nephro-pathy on proteinuria reduction in diabetes type 2 patients. (19284394)
2009
6
PPARgamma2 Pro12Ala polymorphism in relation to free fatty acids concentration and composition in lean healthy Czech individuals with and without family history of diabetes type 2. (18271689)
2008
7
COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its "frizzled" motif is associated with obesity in diabetes type 2 patients. (18345385)
2008
8
Oxidative-antioxidative balance disturbance and risk factors as well as vascular complications in patients with diabetes type 2]. (18175551)
2007
9
Relationship between adiponectin, glycemic control and blood lipids in diabetic type 2 postmenopausal women with and without complication of ischemic heart disease. (16516182)
2006
10
Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. (16581274)
2006
11
Transient ischemic dilation ratio (TID) correlates with HbA(1c) in patients with diabetes type 2 with proven myocardial ischemia according to exercise myocardial SPECT. (17294672)
2006
12
Cystatin C as a marker for detection of early renal failure in diabetes type 2 patients. (16351602)
2005
13
Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy. (16260350)
2005
14
Evaluation of the association between the EQ-5D (health-related utility) and body mass index (obesity) in hospital-treated people with Type 1 diabetes, Type 2 diabetes and with no diagnosed diabetes. (16241910)
2005
15
Comparison of the effects of angiotensin receptor antagonist, angiotensin converting enzyme inhibitor, and their combination on regression of left ventricular hypertrophy of diabetes type 2 patients on recent onset hemodialysis therapy. (15274684)
2004
16
Insulin resistance and diabetes type 2 in overweight children]. (14606353)
2003
17
Gastrointestinal transit in an animal model of human diabetes type 2: relationship to gut neuroendocrine peptide contents. (12602782)
2002
18
The autosomal dominant trait of obesity, acanthosis nigricans, hypertension, ischemic heart disease and diabetes type 2. (11805435)
2001
19
New hypoglycemic drugs in treatment of diabetes type 2]. (11107871)
2000
20
Personal experience with combined treatment of gliclazide and insulin in patients with non-insulin-dependent diabetes (type 2) and late secondary failure of sulphonylureas]. (8415212)
1993

Variations for Diabetes, Type 2

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Sources:
64UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 7dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Diabetes, Type 2:

64 (show all 11)
id Symbol AA change Variation ID SNP ID
1AKT2p.Arg274HisVAR_067310
2HNF1Bp.Ser465ArgVAR_017665
3HNF4Ap.Val402IleVAR_004670rs137853337
4INSRp.Arg1191GlnVAR_004098
5INSRp.Thr858AlaVAR_015917rs182552223
6INSRp.Arg1158GlnVAR_015927
7IRS1p.Ser1043TyrVAR_005302
8IRS1p.Cys1095TyrVAR_005303
9MAPK8IP1p.Ser59AsnVAR_012243
10PPP1R3Ap.Ala931GluVAR_019699rs35449651
11SLC2A4p.Val383IleVAR_007170rs121434581

Clinvar genetic disease variations for Diabetes, Type 2:

1 (show all 16)
id Gene Name Type Significance SNP ID Assembly Location
1HNF1BNM_000458.2(HNF1B): c.1395C> G (p.Ser465Arg)single nucleotide variantPathogenicrs121918673GRCh37Chr 17, 36061127: 36061127
2PAX4NM_006193.2(PAX4): c.361C> T (p.Arg121Trp)single nucleotide variantPathogenicrs114202595GRCh37Chr 7, 127254587: 127254587
3AKT2NM_001626.5(AKT2): c.821G> A (p.Arg274His)single nucleotide variantPathogenicrs121434593GRCh37Chr 19, 40743886: 40743886
4INSRNM_000208.2(INSR): c.3572G> A (p.Arg1191Gln)single nucleotide variantPathogenicrs121913150GRCh37Chr 19, 7120718: 7120718
5INSRNM_000208.2(INSR): c.3034G> A (p.Val1012Met)single nucleotide variantLikely pathogenic, Pathogenicrs1799816GRCh37Chr 19, 7125518: 7125518
6GPD2NM_001083112.2(GPD2): c.1904T> C (p.Phe635Ser)single nucleotide variantPathogenicrs121918407GRCh37Chr 2, 157435621: 157435621
7SLC2A2NM_000340.1(SLC2A2): c.589G> A (p.Val197Ile)single nucleotide variantPathogenicrs121909741GRCh37Chr 3, 170724960: 170724960
8GCGRNM_000160.4(GCGR): c.118G> A (p.Gly40Ser)single nucleotide variantPathogenicrs1801483GRCh37Chr 17, 79767715: 79767715
9IRS1IRS1, 3-BP DEL, GLY723deletionPathogenic
10IRS1NM_005544.2(IRS1): c.1823C> G (p.Thr608Arg)single nucleotide variantPathogenicrs104893642GRCh37Chr 2, 227661632: 227661632
11MAPK8IP1NM_005456.3(MAPK8IP1): c.176G> A (p.Ser59Asn)single nucleotide variantPathogenicrs119489103GRCh37Chr 11, 45919710: 45919710
12NEUROD1NM_002500.4(NEUROD1): c.332G> T (p.Arg111Leu)single nucleotide variantPathogenicrs104893649GRCh37Chr 2, 182543256: 182543256
13PDX1NM_000209.3(PDX1): c.492G> T (p.Glu164Asp)single nucleotide variantPathogenic, risk factorrs80356661GRCh37Chr 13, 28498478: 28498478
14ABCC8NM_001287174.1(ABCC8): c.4138C> T (p.Arg1380Cys)single nucleotide variantPathogenicrs137852673GRCh37Chr 11, 17417462: 17417462
15ABCC8NM_001287174.1(ABCC8): c.1744C> G (p.Leu582Val)single nucleotide variantPathogenicrs137852674GRCh37Chr 11, 17452434: 17452434
16HNF4ANM_000457.4(HNF4A): c.1204G> A (p.Val402Ile)single nucleotide variantPathogenicrs137853337GRCh37Chr 20, 43057049: 43057049

Expression for genes affiliated with Diabetes, Type 2

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetes, Type 2

Search GEO for disease gene expression data for Diabetes, Type 2.

Pathways for genes affiliated with Diabetes, Type 2

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Sources:
50PathCards, 54R&D Systems, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 61Tocris Bioscience, 51PharmGKB, 5Cell Signaling Technology
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Pathways related to Diabetes, Type 2 according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7PPARG, AKT2, HNF4A
29.7INSR, INS
3
Show member pathways
9.7SLC2A4, GPD2, PPARG
4
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.7INSR, IRS1, AKT2
59.6SLC2A4, AKT2, IRS1
69.6SLC2A4, AKT2, IRS1
7
Show member pathways
Nuclear Receptors38
9.5PPARG, HNF4A, NR1H2
89.4AKT2, INSR, INS
9
Show member pathways
Signaling Pathways in Glioblastoma38
9.4AKT2, IRS1, INS
10
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.4AKT2, IRS1, INS
11
Show member pathways
9.4HNF4A, INSR, INS
12
Show member pathways
9.4PPARG, PPP1R3A, INSR, AKT2
139.4INS, INSR, IRS1
149.4IRS1, INSR, INS
159.4IRS1, INSR, INS
169.3SLC2A4, HNF4A, AKT2, INSR
17
Show member pathways
9.3INSR, IRS1, AKT2, SLC2A4
18
Show member pathways
9.2NR1H2, INS, PPARG
19
Show member pathways
9.2INS, AKT2, HNF1B, HNF4A
20
Show member pathways
Insulin Pathway38
9.1INS, INSR, IRS1, AKT2
219.1INS, INSR, IRS1, AKT2
22
Show member pathways
9.1AKT2, IRS1, INSR, INS
239.1PPARG, INS, IRS1, SLC2A4
24
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.0AKT2, IL18, AGTR1
258.9PPP1R3A, INSR, IRS1, AKT2, SLC2A4
26
Show member pathways
8.9PPARG, INS, INSR, IRS1, AKT2
27
Show member pathways
8.9PPARG, PPP1R3A, INS, INSR, AKT2
28
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.8INS, INSR, IRS1, AKT2, SLC2A4
29
Show member pathways
8.8INS, INSR, IRS1, AKT2, SLC2A4
30
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.8SLC2A4, AKT2, IRS1, INSR, INS
318.7PPP1R3A, INS, INSR, AKT2, SLC2A4
32
Show member pathways
8.7PPP1R3A, INS, INSR, IRS1, SLC2A4
33
Show member pathways
8.6PPP1R3A, INS, INSR, IRS1, AGTR1
34
Show member pathways
8.6PPARG, INS, AKT2, HNF1B, HNF4A, SLC2A4
35
Show member pathways
8.5SLC2A4, HNF4A, HNF1B, IRS1, INSR, INS
368.3PPARG, INS, INSR, IRS1, AKT2, HNF4A
37
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.2PPARG, PPP1R3A, INS, INSR, IRS1, AKT2
38
Show member pathways
8.1INSR, IRS1, AKT2, IL18, MAPK8IP1, SLC2A4
39
Show member pathways
8.1PPP1R3A, INS, INSR, IL18, SLC2A4
40
Show member pathways
7.3INS, INSR, IRS1, AKT2, IL18, MAPK8IP1
41
Show member pathways
7.3PPP1R3A, INSR, IRS1, AKT2, IL18, COL18A1

Compounds for genes affiliated with Diabetes, Type 2

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Diabetes, Type 2 according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1vanadium459.8SLC2A4, IRS1, INSR
2vanadyl sulfate459.7INS, INSR, IRS1
3moxonidine459.6INS, INSR, IRS1
4glimepiride45 51 1111.5INSR, PPARG, INS, SLC2A4
5aicar45 24 1111.4PPARG, INS, SLC2A4, INSR
6c-peptide459.4INS, HNF4A, INSR, IRS1
7streptozotocin459.3SLC2A4, INSR, IRS1, INS
8gw966245 2910.3NR1H2, PPARG, AGTR1
9losartan45 51 29 1112.3SLC2A4, PPARG, IRS1, AGTR1
10fenofibrate45 51 1111.3PPARG, INS, INSR, NR1H2
11repaglinide51 45 1111.2NR1H2, INS, PPARG
12telmisartan45 29 1111.2NR1H2, PPARG, INS, AGTR1
13sterol459.2PPARG, NR1H2, IRS1, SLC2A4, HNF4A
14glibenclamide45 29 51 6112.1INS, INSR, SLC2A4, NR1H2
15thiazolidinedione459.0PPARG, INS, IRS1, NR1H2, SLC2A4
16palmitate458.9INSR, IRS1, HNF4A, SLC2A4, PPARG, INS
17uric acid45 249.9HNF1B, INS, CST3, AGTR1
182-deoxyglucose45 119.9INS, PPARG, PPP1R3A, INSR, IRS1, SLC2A4
19aspirin45 51 29 2411.7PPARG, IL18, IRS1, AGTR1, HNF4A
20genistein45 29 61 3 24 1113.7PPARG, AGTR1, NR1H2, IRS1, SLC2A4, INSR
21metformin45 51 1110.7NR1H2, INS, INSR, IRS1, PPARG, SLC2A4
22pioglitazone29 45 51 1111.7SLC2A4, IRS1, NR1H2, INSR, PPARG, INS
23troglitazone45 29 61 1111.7PPARG, INS, INSR, IRS1, SLC2A4, NR1H2
24ibmx45 61 2910.7INS, INSR, PPARG, IRS1, SLC2A4, NR1H2
25fatty acid458.6IRS1, HNF4A, NR1H2, SLC2A4, INS, PPARG
26threonine458.5INSR, MAPK8IP1, IRS1, CST3, HNF4A, SLC2A4
27glycogen45 249.5SLC2A4, HNF4A, AKT2, IRS1, PPP1R3A, INS
28tamoxifen45 51 29 1111.5AKT2, IRS1, NR1H2, SLC2A4, AGTR1
29glycerol45 24 1110.4NR1H2, SLC2A4, HNF4A, INSR, INS, PPARG
30phosphatidylinositol458.4IRS1, AGTR1, SLC2A4, AKT2, HNF4A, INS
31n acetylcysteine458.4AGTR1, INSR, PPARG, IRS1, IL18, CST3
32epinephrine45 24 1110.3INSR, INS, PPP1R3A, AGTR1, IL18
33cycloheximide458.2IL18, IRS1, INSR, PPARG, AGTR1, SLC2A4
34sb 20358045 619.2IRS1, PPARG, INSR, AKT2, IL18, SLC2A4
35rapamycin458.1IRS1, AKT2, IL18, SLC2A4, INSR, INS
36ly294002458.1SLC2A4, PPARG, INS, INSR, IRS1, AKT2
37creatinine457.8IL18, AGTR1, SLC2A4, CST3, INS, INSR
38retinoic acid45 248.8IL18, HNF4A, HNF1B, IRS1, NR1H2, PPARG
39h2o2457.8INSR, IRS1, SLC2A4, AGTR1, GPD2, IL18
40glutamate457.6AGTR1, NR1H2, INS, INSR, HNF4A, IRS1
41testosterone45 61 24 1110.6PPARG, INS, INSR, HNF4A, SLC2A4, NR1H2
42rosiglitazone29 45 51 24 1111.5IRS1, AGTR1, SLC2A4, NR1H2, IL18, INSR
43cholesterol45 29 24 1110.4INS, AGTR1, HNF1B, NR1H2, HNF4A, CST3
44estrogen457.3NR1H2, HNF4A, AKT2, IRS1, PPARG, INS
45arginine457.1IRS1, CST3, INSR, INS, HNF1B, HNF4A
46dexamethasone45 51 29 119.7INS, SLC2A4, AGTR1, PPARG, INSR, IRS1
47alanine456.7IRS1, SLC2A4, NR1H2, HNF4A, CST3, IL18
48serine456.4IRS1, AKT2, CST3, IL18, NR1H2, SLC2A4
49lipid456.2INS, NR1H2, HNF4A, CST3, AKT2, IRS1
50glucose455.4GPD2, IRS1, AKT2, IL18, MAPK8IP1, CST3

GO Terms for genes affiliated with Diabetes, Type 2

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16Gene Ontology
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Cellular components related to Diabetes, Type 2 according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor complexGO:0058999.9IRS1, INSR

Biological processes related to Diabetes, Type 2 according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glucose import in response to insulin stimulusGO:200127510.3AKT2, IRS1
2positive regulation of glucose metabolic processGO:01090710.2IRS1, AKT2
3positive regulation of fatty acid beta-oxidationGO:03200010.2IRS1, AKT2
4negative regulation of interferon-gamma-mediated signaling pathwayGO:06033610.1NR1H2, PPARG
5lipid homeostasisGO:05508810.1HNF4A, PPARG
6negative regulation of cholesterol storageGO:01088710.0PPARG, NR1H2
7negative regulation of acute inflammatory responseGO:00267410.0INS, PPARG
8positive regulation of respiratory burstGO:06026710.0INS, INSR
9negative regulation of macrophage derived foam cell differentiationGO:0107459.9NR1H2, PPARG
10positive regulation of glycolytic processGO:0458219.9INSR, INS
11positive regulation of insulin receptor signaling pathwayGO:0466289.9IRS1, INS
12activation of protein kinase B activityGO:0321489.8INSR, INS
13endocrine pancreas developmentGO:0310189.8INS, HNF1B, HNF4A
14positive regulation of nitric oxide biosynthetic processGO:0454299.7INSR, INS
15brown fat cell differentiationGO:0508739.6SLC2A4, PPARG
16positive regulation of mitosisGO:0458409.6INSR, INS
17negative regulation of proteolysisGO:0458619.5NR1H2, INS
18positive regulation of glycogen biosynthetic processGO:0457259.5INS, INSR, IRS1, AKT2
19positive regulation of glucose importGO:0463269.5AKT2, IRS1, INSR, INS
20insulin receptor signaling pathwayGO:0082869.5INS, INSR, IRS1, AKT2
21transcription initiation from RNA polymerase II promoterGO:0063679.5PPARG, HNF4A, NR1H2
22cellular response to insulin stimulusGO:0328699.4PPARG, INSR, IRS1, AKT2, SLC2A4
23positive regulation of cellular protein metabolic processGO:0322709.4INS, NR1H2, AGTR1
24G-protein coupled receptor signaling pathwayGO:0071869.3PPARG, INS, INSR, AGTR1
25positive regulation of cell migrationGO:0303359.1COL18A1, IRS1, INSR, INS
26positive regulation of cell proliferationGO:0082848.9INS, INSR, IRS1, COL18A1
27glucose homeostasisGO:0425938.9SLC2A4, HNF4A, IRS1, INSR, INS, PPARG

Molecular functions related to Diabetes, Type 2 according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:04354810.0IRS1, INSR
2SH2 domain bindingGO:0421699.9IRS1, INSR
3retinoid X receptor bindingGO:0469659.8PPARG, NR1H2
4ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.6PPARG, HNF4A, NR1H2
5transcription regulatory region DNA bindingGO:0442129.6HNF4A, HNF1B, PPARG
6steroid hormone receptor activityGO:0037079.6NR1H2, HNF4A, PPARG
7insulin-like growth factor receptor bindingGO:0051599.6IRS1, INSR, INS
8insulin receptor bindingGO:0051589.4IRS1, INS
9sequence-specific DNA bindingGO:0435659.2PPARG, HNF1B, HNF4A, NR1H2
10protein bindingGO:0055155.9AGTR1, PPARG, INS, INSR, IRS1, AKT2

Products for genes affiliated with Diabetes, Type 2

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Sources for Diabetes, Type 2

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet