MCID: DBT008
MIFTS: 47

Diabetic Angiopathy malady

Cardiovascular category

Summaries for Diabetic Angiopathy

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Diabetic angiopathy is a form of angiopathy associated with diabetes mellitus. While not exclusive, the... more...

MalaCards: Diabetic Angiopathy, also known as diabetic angiopathies, is related to type 1 diabetes and vasculitis. An important gene associated with Diabetic Angiopathy is AGER (advanced glycosylation end product-specific receptor), and among its related pathways are Platelet activation, signaling and aggregation and superoxide radicals degradation. The drug pentoxifylline and the compounds estrogen and superoxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, monocytes and endothelial, and related mouse phenotypes are reproductive system and integument.

Aliases & Classifications for Diabetic Angiopathy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

diabetic angiopathy 8 10
diabetic angiopathies 45 61
diabetic vascular disorder 8


External Ids:

Disease Ontology8 DOID:11713
MeSH35 D003925
NCIt40 C35610

Related Diseases for Diabetic Angiopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diabetic Angiopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1type 1 diabetes30.1NOS2, INS, SOD2
2vasculitis30.1SELE, THBD, FN1, CCL2
3diabetic nephropathy30.0ADM, SERPINE1, THBD, INS, NAGLU, FN1
4vascular disease30.0SERPINE1, SELE, NOS2, THBD, INS, RETN
5type 1 diabetes mellitus10.1
6diabetic peripheral angiopathy10.1
7nephrotic syndrome10.0NAGLU
8eclampsia10.0THBD
9lupus erythematosus10.0THBD
10cerebrovascular disease10.0ADM
11lung cancer10.0FN1
12dilated cardiomyopathy10.0EDN1
13graves' disease10.0SELE
14blindness10.0INS
15pheochromocytoma10.0ADM
16acute pancreatitis10.0RETN
17morbid obesity10.0INS
18nephrosclerosis10.0ADM
19meningitis10.0CAT
20viral hepatitis10.0FN1
21myopathy10.0INS
22pneumoconiosis10.0CAT
23portal hypertension10.0EDN1
24hepatopulmonary syndrome10.0EDN1
25gingivitis10.0TNFRSF11B
26dermatitis10.0SELE
27choriocarcinoma10.0ADM
28cushing's syndrome10.0INS
29vesicoureteral reflux10.0NAGLU
30urticaria10.0SELE
31pyelonephritis10.0NAGLU
32cataract10.0CAT
33osteomyelitis10.0CAT
34multiple myeloma10.0TNFRSF11B
35age related macular degeneration10.0LIPC
36myeloid leukemia10.0FN1
37wilson disease10.0CAT
38thrombocytopenia10.0THBD
39hyperparathyroidism10.0TNFRSF11B
40cystitis10.0NAGLU
41hyperuricemia10.0INS
42hepatitis c10.0SOD2
43retinal detachment10.0FN1
44oligohydramnios10.0NAGLU
45amyotrophic lateral sclerosis10.0SOD2
46down syndrome10.0SOD2
47allergic rhinitis10.0SELE
48wegener's granulomatosis10.0SELE
49cor pulmonale10.0EDN1
50progeria10.0SOD2

Graphical network of the top 20 diseases related to Diabetic Angiopathy:



Diseases related to diabetic angiopathy

Clinical Features for Diabetic Angiopathy

Drugs & Therapeutics for Diabetic Angiopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Angiopathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Angiopathy

Search NIH Clinical Center for Diabetic Angiopathy

Search CenterWatch for Diabetic Angiopathy

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Diabetic Angiopathy

Anatomical Context for Diabetic Angiopathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Diabetic Angiopathy:

33
Thyroid, Monocytes, Endothelial

Animal Models for Diabetic Angiopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Diabetic Angiopathy:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.1LIPC, SOD2
2MP:001077110.0INS, NAGLU, FN1, SOD2
3MP:00053909.9NAGLU, TNFRSF11B, AGER, FN1
4MP:00053919.9NAGLU, SOD2, SELE
5MP:00053699.9PDGFRB, INS, IGFBP3, AGER
6MP:00053679.9AGER, EDN1, NAGLU, ADM, SOD2
7MP:00053959.9ADM, NOS2, FN1
8MP:00020069.8CCL2, NOS2
9MP:00053829.1CCL2, PDGFRB, TNFRSF11B, EDN1, FN1, NAGLU
10MP:00028739.0CCL2, PDGFRB, EDN1, SELE, THBD, INS
11MP:00053758.6SERPINE1, CCL2, SOD2, PDGFRB, IGFBP3, RETN
12MP:00053768.3CCL2, PDGFRB, IGFBP3, FN1, RETN, INS
13MP:00053868.3IGFBP3, CCL2, SOD2, NAGLU, INS, NOS2
14MP:00053708.3SELE, ADM, SERPINE1, NOS2, CCL2, SOD2
15MP:00053978.2AGER, TNFRSF11B, PDGFRB, SOD2, CCL2, INS
16MP:00053857.9ADM, CCL2, SOD2, PDGFRB, TNFRSF11B, EDN1
17MP:00053787.9CCL2, SOD2, PDGFRB, IGFBP3, TNFRSF11B, AGER
18MP:00053847.8SOD2, CAT, CCL2, PDGFRB, TNFRSF11B, NOS2
19MP:00053877.8FN1, NAGLU, SERPINE1, ADM, SELE, NOS2
20MP:00107687.8SERPINE1, ADM, SELE, NOS2, EDN1, THBD

Publications for Diabetic Angiopathy

Sources:
51PubMed
See all sources

Articles related to Diabetic Angiopathy:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Aspirin resistance, platelet turnover, and diabetic angiopathy: a 2011 update. (22142668)
2012
2
Diabetic angiopathy and angiogenic defects. (22853690)
2012
3
Peroxynitrite-induced nitration of cyclooxygenase-2 and inducible nitric oxide synthase promotes their binding in diabetic angiopathy. (20607198)
2010
4
Molecular pathology of oxidative stress in diabetic angiopathy: role of mitochondrial and cellular pathways. (20022399)
2010
5
Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily. (20098449)
2010
6
Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy. (16428460)
2006
7
Diabetic angiopathy: new experimental and clinical aspects. (15918103)
2005
8
The role of nitric oxide in the development of diabetic angiopathy. (15156413)
2004
9
Pathophysiological mechanisms of diabetic angiopathy. (12623164)
2003
10
Advanced glycation end products in adolescents and young adults with diabetic angiopathy. (10955941)
2000
11
Plasminogen activator inhibitor-1 and apolipoprotein E gene polymorphisms and diabetic angiopathy. (10809802)
2000
12
Circulating IGF-I and its protective role in the pathogenesis of diabetic angiopathy. (10651746)
2000
13
Pathophysiologic aspects of diabetic angiopathy]. (10421989)
1999
14
Quality Control of Diabetes Care and Chronic Complications in Young People after St. Vincent and Kos. Proceedings of the 4th International Workshop Diabetic Angiopathy in Children. Berlin, Germany, September 4-6, 1997. (9742011)
1998
15
Controversies on the pathogenesis of diabetic angiopathy: which treatment for normotensive adolescents with microalbuminuria and type 1 diabetes? (9642665)
1998
16
Von Willebrand factor in diabetic angiopathy. (9805643)
1998
17
Endothelial dysfunction and pathogenesis of diabetic angiopathy. (9217873)
1997
18
Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy. (8603774)
1996
19
Diabetic angiopathy: tracking down the culprits. (8807468)
1996
20
Prostacyclin-stimulating factor, novel protein, and diabetic angiopathy. (8674874)
1996
21
The role of hyperglycemia and hyperinsulinemia in the pathogenesis of diabetic angiopathy. (8905209)
1996
22
The effect of vitamin C on the lipolytic activity in type-II diabetics with angiopathy]. (2069272)
1991
23
Acupuncture in the treatment of diabetic angiopathy of the lower extremities]. (1788185)
1991
24
Lack of correlation of glycosylated haemoglobin level with the duration of diabetes or diabetic angiopathy. (3767198)
1986
25
Influence of norepinephrine on vessel geometry of the intact femoral artery in juvenile insulin-dependent diabetics-evidence of early diabetic angiopathy in central arteries. (7039161)
1982
26
Is sickle cell trait an additional risk factor for diabetic angiopathy? (7347676)
1981
27
Study on relationship between erythrocyte filtration and other risk factors in diabetic angiopathy. (7188119)
1981
28
Clinical considerations and treatment of diabetic angiopathy. (393791)
1979
29
Diabetic angiopathy--its lessons in vascular physiology. (356570)
1978
30
Fragmentation haemolysis in patients with severe diabetic angiopathy. (974041)
1976
31
Wound healing: a model for the study of diabetic angiopathy. (971788)
1976
32
Rheographic estimation of peripheral diabetic angiopathy. (1131183)
1975
33
The use of photopletysmography in the diagnosis of diabetic angiopathy. (4416574)
1974
34
Growth hormoe and diabetic angiopathy. (4720360)
1973
35
Diabetic angiopathy and neuropathy. A review with special reference to circulation in the extremities, the effect of hypophysectomy on capillary resistance and capillary permeability, functional abnormalities in early diabetes. (4571960)
1972
36
Recent contributions to the study of diabetic angiopathy and neuropathy. (4345261)
1972
37
The pathogenesis of diabetic angiopathy and growth hormone. (4942397)
1971
38
Tobacco and diabetic angiopathy. (5146916)
1971
39
Growth hormone and diabetic angiopathy. (5146909)
1971
40
Diabetes, diabetic angiopathy, and growth hormone. (4194508)
1970
41
Diabetic angiopathy and sulfonylurea therapy. (5697884)
1968
42
A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. IV. Diabetic retinal angiopathy. (5684307)
1968
43
Diabetic angiopathy and L-xylulose. (5953445)
1966
44
Diabetic angiopathy (pathological findings). (5213746)
1965
45
The relationship between diabetic angiopathy and neuropathy. (5859900)
1965
46
DIABETIC ANGIOPATHY. (14271792)
1965
47
HYPOPHYSEO-ADRENAL FUNCTION IN DIABETIC ANGIOPATHY. (14175499)
1964
48
Hypophysectomy for diabetic angiopathy. A preliminary report. (13931672)
1962
49
Experimental studies on the pathogenesis of diabetic angiopathy. (14398108)
1955
50
Diabetic angiopathy: a specific vascular disease. (13131862)
1954

Genetic Variations for Diabetic Angiopathy

Expression for genes affiliated with Diabetic Angiopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Angiopathy

Search GEO for disease gene expression data for Diabetic Angiopathy.

Pathways for genes affiliated with Diabetic Angiopathy

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore
See all sources

Compounds for genes affiliated with Diabetic Angiopathy

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Diabetic Angiopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6LIPC
2superoxide45 2411.5CCL2
3cycloheximide4510.5SOD2, CAT
4uric acid45 2411.5SERPINE1
5norepinephrine45 11 2412.4ADM, RETN
6pge24510.2FN1
7nadph45 2411.1NAGLU, SOD2, ADM, PDGFRB
8glucose459.8ADM, THBD, NAGLU, IGFBP7, IGFBP3, PDGFRB
9heparin45 29 11 2412.7NAGLU, TNFRSF11B, LIPC, SELE, AGER, FN1
10probucol45 1110.7CAT, CCL2, EDN1, LIPC, SELE
11endotoxin459.7ADM, SERPINE1, SELE, THBD, RETN
12losartan45 50 29 1112.7ADM, SELE, IGFBP3, EDN1, THBD, SERPINE1
13dexamethasone45 50 29 1112.7SOD2, TNFRSF11B, FN1, RETN, INS
14polymyxin b459.6SELE, CCL2, SERPINE1, TNFRSF11B, THBD
15malondialdehyde459.6CAT, AOC3, AGER, NAGLU, ADM, SOD2
16h2o2459.5THBD, AOC3, PDGFRB, CAT, NAGLU
17aspartate459.5CCL2, IGFBP3, RETN, NAGLU, SELE
18vitamin a45 11 2411.5NAGLU, CAT, RETN, SOD2, LIPC
19nitroglycerin45 1110.5NOS2, ADM, EDN1, TNFRSF11B, SOD2
20thiazolidinedione459.4INS, SERPINE1, CCL2, THBD, RETN
21ang ii459.4NOS2, CCL2, EDN1, ADM, PDGFRB
22c-peptide459.3NAGLU, SERPINE1, INS, LIPC, IGFBP3, RETN
23fenofibrate45 50 1111.3RETN, INS, SELE, LIPC, CCL2, SERPINE1
24p003459.3ADM, SERPINE1, IGFBP3, LIPC, AOC3, RETN
25pioglitazone45 50 29 1112.2INS, RETN, CCL2, FN1, SERPINE1, LIPC
26cyclosporin a45 29 6011.2TNFRSF11B, EDN1, LIPC, NAGLU, IGFBP3, FN1
27sodium nitroprusside459.2CAT, NOS2, ADM, SERPINE1, EDN1, SOD2
28serine459.2TNFRSF11B, FN1, IGFBP7, SELE, CCL2, AGER
29homocysteine45 2410.1THBD, SERPINE1, ADM, SELE, NAGLU, RETN
308-isoprostane459.1CCL2, CAT, EDN1, RETN, INS, THBD
31oxygen45 2410.1LIPC, RETN, ADM, AOC3, CCL2, NAGLU
32lactate459.1SELE, SOD2, NAGLU, INS, IGFBP3, THBD
33isoproterenol45 1110.1SERPINE1, SELE, NOS2, RETN, CCL2, EDN1
34sb 20358045 6010.0EDN1, NOS2, SELE, SERPINE1, FN1, CCL2
35atorvastatin45 50 29 11 2413.0SELE, LIPC, EDN1, TNFRSF11B, CCL2, THBD
36creatinine458.9AOC3, TNFRSF11B, AGER, IGFBP3, SELE, THBD
37prostacyclin458.9IGFBP7, AGER, CCL2, EDN1, FN1, THBD
38vitamin d458.8IGFBP3, TNFRSF11B, SERPINE1, CCL2, SOD2, FN1
39genistein45 29 60 2 11 2413.8FN1, TNFRSF11B, NOS2, SERPINE1, CCL2, SOD2
40fibrinogen458.8THBD, CCL2, SERPINE1, SELE, INS, RETN
41epinephrine45 11 2410.6INS, AOC3, ADM, EDN1, IGFBP3, SOD2
42alanine458.6FN1, SOD2, ADM, PDGFRB, SELE, IGFBP3
43arginine458.5NOS2, CCL2, THBD, FN1, ADM, INS
44actinomycin d458.4CAT, EDN1, FN1, RETN, THBD, NOS2
45testosterone45 60 11 2411.3TNFRSF11B, ADM, SERPINE1, SELE, RETN, IGFBP3
46ly294002458.2PDGFRB, TNFRSF11B, IGFBP3, FN1, RETN, INS
47cholesterol45 29 11 2410.7INS, TNFRSF11B, AOC3, AGER, ADM, IGFBP3
48lipid457.6CAT, NAGLU, INS, THBD, SELE, SOD2
49vegf457.6ADM, SERPINE1, SELE, NOS2, THBD, RETN
50nitric oxide45 11 249.6CCL2, CAT, SOD2, SERPINE1, SELE, NOS2

GO Terms for genes affiliated with Diabetic Angiopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2TNFRSF11B, EDN1, AGER, IGFBP3, FN1, RETN
2extracellular spaceGO:0056157.5ADM, CCL2, TNFRSF11B, EDN1, LIPC, IGFBP3

Biological processes related to Diabetic Angiopathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood coagulationGO:03019510.2EDN1, THBD, SERPINE1
2response to hyperoxiaGO:05509310.2CAT, SOD2, PDGFRB
3positive regulation of mitosisGO:04584010.2INS, EDN1, PDGFRB
4response to woundingGO:00961110.2AGER, FN1, ADM
5positive regulation of vasodilationGO:04590910.1INS, NOS2, ADM
6maternal process involved in parturitionGO:06013710.1EDN1, CCL2
7positive regulation of heart rateGO:01046010.1ADM, EDN1
8positive regulation of nitric oxide biosynthetic processGO:04542910.1INS, EDN1, SOD2
9positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1INS, PDGFRB, CAT
10negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:190217610.1SOD2, INS
11response to lipopolysaccharideGO:03249610.0SOD2, EDN1, SELE, ADM
12negative regulation of smooth muscle cell migrationGO:0149129.8SERPINE1, IGFBP3
13negative regulation of fibrinolysisGO:0519189.8SERPINE1, THBD
14cellular response to lipopolysaccharideGO:0712229.7SERPINE1, NOS2, CCL2
15blood coagulationGO:0075969.5FN1, THBD, NOS2, SELE, SERPINE1
16inflammatory responseGO:0069549.5CCL2, AOC3, AGER, NOS2, SELE
17response to hypoxiaGO:0016669.5ADM, NOS2, EDN1, SOD2, CAT, CCL2

Molecular functions related to Diabetic Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6ADM, INS, RETN, EDN1
2receptor bindingGO:0051028.8ADM, CCL2, CAT, PDGFRB, NOS2, SERPINE1

Products for genes affiliated with Diabetic Angiopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetic Angiopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet