Diabetic Angiopathy malady

Wikipedia: Diabetic angiopathy is a form of angiopathy associated with diabetes mellitus. While not exclusive, the...⁴⁴ more...

MalaCards: Diabetic Angiopathy, also known as diabetic angiopathies, is related to pancreatitis and asphyxia neonatorum. An important gene associated with Diabetic Angiopathy is AOC3 (amine oxidase, copper containing 3 (vascular adhesion protein 1)), and among its related pathways is Blood Coagulation Signaling Pathways. The drug pentoxifylline and the compounds glucose and carbohydrates have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, and related mouse phenotypes are hematopoietic system and liver/biliary system.

Aliases & Descriptions:

diabetic angiopathy 6 8 diabetic angiopathies 32 43

diabetic vascular disorder 6

Diseases related to diabetic angiopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 488)

id	Related Disease	Score	Top Affiliating Genes
1	pancreatitis	19.5	RETN, VWF, SELE, SERPINE1, NAGLU, BMP6
2	asphyxia neonatorum	13.5	NAGLU, CAT, ADM
3	hypertensive nephropathy	13.5	NAGLU, INS, EDN1
4	oligohydramnios	13.5	NAGLU, EDN1, ADM
5	hematuria	13.4	NAGLU, FN1, INS
6	lipoid nephrosis	13.4	NAGLU, CCL2, ADM
7	anthracosis	13.4	BMP6, CCL2
8	renovascular hypertension	13.4	INS, CAT, EDN1
9	combined hyperlipemia	13.4	LIPC, INS
10	brain edema	13.3	CAT, EDN1, AGER
11	thromboangiitis obliterans	13.3	SELE, SERPINE1, EDN1
12	rheumatic fever	13.3	INS, CAT, ADM
13	empty sella syndrome	13.2	INS, IGFBP3
14	eisenmenger syndrome	13.2	VWF, EDN1, THBD
15	pyelonephritis	13.2	NAGLU, INS, CCL2, ADM
16	heparin-induced thrombocytopenia	13.2	SELE, SERPINE1, THBD
17	chronic rapidly progressive glomerulonephritis	13.2	SERPINE1, NAGLU, FN1, ADM
18	x-linked magnesium deficiency with epstein-barr virus infection and neoplasia	13.2	INS, CAT, EDN1, DNAH8
19	obstructive jaundice	13.2	CCL2, CAT, EDN1, THBD
20	periodontitis	13.2	CCL2, TNFRSF11B, AGER
21	thrombasthenia	13.2	VWF, NAGLU, FN1
22	vesicoureteral reflux	13.1	SERPINE1, NAGLU, EDN1, ADM
23	extrinsic allergic alveolitis	13.1	FN1, CCL2, SOD2
24	proliferative vitreoretinopathy	13.1	BMP6, FN1, CCL2, ADM
25	moyamoya disease	13.1	RETN, CCL2, PDGFRB
26	diabetic ketoacidosis	13.1	VWF, INS, AGER
27	duodenal ulcer	13.1	INS, CAT, EDN1, DNAH8
28	glanzmann's thrombasthenia	13.1	VWF, NAGLU, FN1
29	temporal arteritis	13.1	VWF, CCL2, EDN1
30	myocardial stunning	13.1	CAT, NOS2, EDN1
31	vitreoretinopathy	13.1	BMP6, FN1, CCL2, ADM
32	hyperprolactinemia	13.1	SELE, INS, IGFBP3
33	cor pulmonale	13.1	VWF, CAT, EDN1, AGER
34	jaundice	13.1	CCL2, CAT, EDN1, THBD
35	urolithiasis	13.1	NAGLU, CCL2, SOD2
36	hepatic lipase deficiency	13.1	LIPC, APOE
37	nephrosclerosis	13.1	SERPINE1, INS, CCL2, ADM
38	inclusion body myositis	13.0	SELE, CCL2, CAT, AGER, THBD
39	adult respiratory distress syndrome	13.0	SELE, NOS2, THBD
40	familial hyperlipidemia	13.0	LIPC, INS, APOE
41	fibromatosis	13.0	SERPINE1, FN1, PDGFRB, EDN1
42	idiopathic interstitial pneumonia	13.0	SERPINE1, CCL2, EDN1, THBD
43	critical limb ischemia	13.0	VWF, SELE, EDN1, THBD
44	hemangioendothelioma	13.0	VWF, CCL2, EDN1
45	respiratory failure	13.0	INS, EDN1, THBD, DNAH8, ADM
46	familial combined hyperlipidemia	13.0	LIPC, INS, APOE
47	bleeding diathesis due to gnaq deficiency	13.0	VWF, SERPINE1, THBD
48	cluster headache	13.0	SELE, INS, NOS2
49	peripheral vascular disease	13.0	VWF, SELE, SERPINE1
50	venous insufficiency	13.0	SERPINE1, PDGFRB, DNAH8

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 pentoxifylline

MalaCards organs/tissues related to diabetic angiopathy:

²²

MGI Mouse Phenotypes related to diabetic angiopathy:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.5	SOD2
2	liver/biliary system phenotype	MP:0005370	10.2	ADM, INS, RETN
3	nervous system phenotype	MP:0003631	9.4	THBD, EDN1, INS, NAGLU, VWF
4	renal/urinary system phenotype	MP:0005367	9.2	ADM, SOD2, PDGFRB, APOE, INS, NAGLU
5	immune system phenotype	MP:0005387	9.2	ADM, SOD2, AGER, PDGFRB, AOC3, FN1
6	other phenotype	MP:0005395	8.9	ADM, SOD2, NOS2, APOE, FN1
7	skeleton phenotype	MP:0005390	8.8	TNFRSF11B, INS, FN1, LEP, BMP6, NAGLU
8	pigmentation phenotype	MP:0001186	8.5	NAGLU, LEP, APOE, CCL2, SOD2
9	reproductive system phenotype	MP:0005389	8.5	SOD2, NOS2, CCL2, FN1, LEP, LIPC
10	tumorigenesis	MP:0002006	7.7	SOD2, NOS2, CAT, CCL2, FN1, LEP
11	vision/eye phenotype	MP:0005391	7.5	SOD2, PDGFRB, NOS2, CCL2, APOE, INS
12	digestive/alimentary phenotype	MP:0005381	7.5	THBD, EDN1, PDGFRB, NOS2, CCL2, APOE
13	growth/size phenotype	MP:0005378	7.4	THBD, AGER, PDGFRB, TNFRSF11B, APOE, INS
14	adipose tissue phenotype	MP:0005375	7.1	SOD2, PDGFRB, NOS2, IGFBP3, CCL2, APOE
15	muscle phenotype	MP:0005369	7.1	EDN1, AGER, SOD2, ADM, PDGFRB, NOS2
16	behavior/neurological phenotype	MP:0005386	6.8	ADM, SOD2, AGER, NOS2, IGFBP3, CCL2
17	cellular phenotype	MP:0005384	6.1	TNFRSF11B, NOS2, PDGFRB, AGER, THBD, SOD2
18	cardiovascular system phenotype	MP:0005385	6.0	VWF, ADM, SOD2, THBD, AGER, EDN1
19	mortality/aging	MP:0010768	5.8	TNFRSF11B, NOS2, PDGFRB, EDN1, THBD, SOD2
20	homeostasis/metabolism phenotype	MP:0005376	5.3	CAT, NOS2, PDGFRB, EDN1, AGER, THBD

Articles related to diabetic angiopathy:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Diabetic angiopathy, the complement system and the tu mor necrosis factor superfamily. (20098449)	Flyvbjerg A.	2010	TNFRSF11B
2	Effects of irbesartan on intracellular antioxidant enzyme expression and activity in adolescents and young adults with early diabetic angiopathy. (15983321)	Chiarelli F.... Verrotti A.	2005	SOD2, CCL2, CAT
3	The role of nitric oxide in the development of diabetic angiopathy. (15156413)	Santilli F.... Chiarelli F.	2004	NOS2
4	Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects. (15270792)	Matsuda M.... Kaku K.	2004	LEP, RETN
5	Growth hormone, insulin-like growth factor and insulin-like growth factor binding protein in young type I diabetes patients with the onset of diabetic angiopathy (12868196)	PeczyA8ska J.... Urban B.	2003	IGFBP3
6	Pathophysiological mechanisms of diabetic angiopathy. (12623164)	Hammes H.P.	2003	DYT10
7	Advanced glycation end products, their receptors and diabetic angiopathy. (11694852)	Wautier J.L.... Guillausseau P.J.	2001	AGER
8	Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes. (11004428)	Tooke J.E.	2000	INS
9	Plasminogen activator inhibitor-1 and apolipoprotein E gene polymorphisms and diabetic angiopathy. (10809802)	Tarnow L.... Parving H.H.	2000	SERPINE1, APOE
10	Pathophysiologic aspects of diabetic angiopathy (10421989)	Wautier J.L.... Wautier M.P.	1999	AGER
11	Urinary free cortisol and its nyctohemeral variation in adolescents and young adults with IDDM: relation to endothelin 1 and indices of diabetic angiopathy. (11517960)	Dacou-Voutetakis C.... Dracopoulou M.	1998	EDN1
12	Von Willebrand factor in diabetic angiopathy. (9805643)	Kessler L.... Pinget M.	1998	VWF, BMP6
13	Effects of xenotransplantation of pancreatic islet cells on immunological state of patients with diabetic angiopathies (9511343)	Koval's'ka I.O.	1997	INS
14	Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy. (8603774)	Inaba T.... Yamada N.	1996	PDGFRB
15	The thromboxane-synthesis inhibitor Ibustrin in the treatment of diabetic angiopathies (9026936)	Shestakova M.V.... Dedov I.I.	1996	INS
16	Prostacyclin-stimulating factor, novel protein, and diabetic angiopathy. (8674874)	Umeda F.... Nawata H.	1996	IGFBP7
17	The medical effect of magnetic-laser therapy in patients with diabetic angiopathies of the lower extremities (9138797)	Shved M.I.... Dudnik A.P.	1996	INS
18	The results of a comparative study of the lipid peroxidation processes and of the malondialdehyde level of the blood cells in patients with diabetic angiopathies and during insulin therapy (7863440)	Rud'ko I.A.... Kubatiev A.A.	1994	INS
19	Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy (8058653)	Efimov A.S.... Sergienko L.M.	1993	INS, DNAH8
20	Acupuncture in the treatment of diabetic angiopathy of the lower extremities (1788185)	Solun M.N.... LiaA-fer A.I.	1991	INS
21	The effect of vitamin C on the lipolytic activity in type-II diabetics with angiopathy (2069272)	Triana Mantilla M.E.... MorejA^n Reinoso O.	1991	LIPC

Genes related to diabetic angiopathy according to GeneCards:

(show all 27)

id	Symbol	Description	Score	GeneCards Section Context
1	AOC3	amine oxidase, copper containing 3 (vascular adhesion protein 1)	11.0
2	IGFBP7	insulin-like growth factor binding protein 7	11.0	Publications
3	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
4	ADM	adrenomedullin	11.0
5	NAGLU	N-acetylglucosaminidase, alpha	11.0
6	FN1	fibronectin 1	11.0
7	THBD	thrombomodulin	11.0
8	EDN1	endothelin 1	11.0	Publications
9	SELE	selectin E	11.0
10	CAT	catalase	11.0	Publications
11	INS	insulin	11.0	Publications
12	RETN	resistin	11.0	Publications
13	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
14	LIPC	lipase, hepatic	11.0	Publications
15	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
16	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
17	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
18	VWF	von Willebrand factor	11.0	Publications
19	FAM172A	family with sequence similarity 172, member A	11.0	Disorders
20	DNAH8	dynein, axonemal, heavy chain 8	11.0	Publications
21	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
22	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
23	BMP6	bone morphogenetic protein 6	11.0	Publications
24	APOE	apolipoprotein E	11.0	Publications
25	LEP	leptin	11.0	Publications
26	DYT10	dystonia 10	11.0	Publications
27	NOS2	nitric oxide synthase 2, inducible	11.0	Publications

Pathways related to diabetic angiopathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Blood Coagulation Signaling Pathways37	9.7	VWF, SERPINE1, THBD

Compounds related to diabetic angiopathy according to GeneDecks:

(show top 50)    (show all 229)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.7	IGFBP7
2	carbohydrates32	10.3	SELE, AOC3, THBD
3	isoproterenol32 9 9	12.1	NOS2, ADM
4	sb 20358032 42	10.7	EDN1, SELE, TNFRSF11B, BMP6
5	sodium nitroprusside32	9.6	DNAH8, CAT, BMP6, VWF
6	n acetylcysteine32	9.5	SELE, APOE, AGER, NAGLU, VWF
7	cysteine32	9.4	PDGFRB, ADM, THBD, IGFBP3, FN1, NAGLU
8	c-peptide32	9.4	LEP, NAGLU, RETN
9	fluvastatin32 34 9 9	12.1	NOS2, THBD, SERPINE1, VWF, CCL2
10	probucol32 9 9	10.9	EDN1, CAT, CCL2, APOE, LIPC, SELE
11	h2o232	8.7	APOE, PDGFRB, VWF, NAGLU, LEP, ADM
12	heparin32 9 18 9	11.7	VWF, SERPINE1, SOD2, AGER, TNFRSF11B, APOE
13	p00332	8.6	IGFBP3, LEP, AOC3, RETN, SERPINE1, ADM
14	fenofibrate32 9 9	10.5	LEP, RETN, SELE, SERPINE1, LIPC, INS
15	epinephrine32 9 18 9	11.5	BMP6, AOC3, IGFBP3, DNAH8, LEP, INS
16	aspartate32	8.5	NAGLU, RETN, BMP6, APOE, TNFRSF11B, THBD
17	8-isoprostane32	8.4	RETN, SELE, SERPINE1, LEP, INS, CCL2
18	testosterone32 9 18 9	11.4	SELE, LIPC, APOE, SOD2, DNAH8, PDGFRB
19	polymyxin b32	8.4	SELE, SERPINE1, CCL2, TNFRSF11B, DYT10, THBD
20	ly29400232	8.3	CCL2, FN1, LEP, RETN, TNFRSF11B, NOS2
21	homocysteine32 18	9.2	ADM, THBD, TNFRSF11B, CCL2, APOE, NAGLU
22	vitamin a32 9 18 9	11.1	IGFBP3, NAGLU, LIPC, CAT, APOE, VWF
23	nitric oxide32 9 18 9	11.1	CCL2, AOC3, BMP6, NAGLU, SELE, RETN
24	aspirin32 34 18	9.9	THBD, TNFRSF11B, IGFBP3, APOE, SELE, VWF
25	lactate32	7.8	SELE, ADM, SOD2, THBD, CAT, VWF
26	fibrinogen32	7.8	FN1, RETN, VWF, SELE, TNFRSF11B, LIPC
27	alanine32	7.7	DNAH8, ADM, RETN, VWF, SELE, NAGLU
28	nifedipine32 9 9	9.7	SELE, BMP6, DYT10, EDN1, AGER, THBD
29	atorvastatin32 34 9 18 9	11.7	RETN, THBD, EDN1, TNFRSF11B, CCL2, APOE
30	betacarotene32	7.7	THBD, CAT, IGFBP3, SOD2, APOE, LEP
31	rosiglitazone32 9 18 9	10.6	IGFBP3, APOE, RETN, SELE, CCL2, LEP
32	phosphatidylcholine32	7.6	THBD, ADM, DYT10, SELE, FN1, LIPC
33	thyroxine32 18	8.6	DNAH8, APOE, THBD, INS, IGFBP3, TNFRSF11B
34	vitamin d32	7.5	SOD2, SERPINE1, TNFRSF11B, THBD, PDGFRB, IGFBP3
35	arginine32	7.5	VWF, LIPC, LEP, FN1, CCL2, EDN1
36	indomethacin32 9 9	9.1	APOE, FN1, LEP, CAT, TNFRSF11B, NOS2
37	losartan32 34 9 9	10.1	VWF, SELE, SERPINE1, NAGLU, BMP6, LEP
38	norepinephrine32 9 18 9	10.0	RETN, ADM, SOD2, DNAH8, EDN1, IGFBP3
39	estrogen32	6.8	LEP, PDGFRB, SERPINE1, LIPC, IGFBP3, RETN
40	actinomycin d32	6.8	THBD, EDN1, NOS2, DYT10, CAT, CCL2
41	tamoxifen32 34 9 9	9.7	ADM, TNFRSF11B, DNAH8, SOD2, SELE, DYT10
42	cyclosporin a32 42	7.6	SOD2, DNAH8, THBD, EDN1, TNFRSF11B, IGFBP3
43	prostacyclin32	6.6	AGER, EDN1, NOS2, IGFBP7, CCL2, APOE
44	lipid32	6.4	ADM, SOD2, THBD, AGER, PDGFRB, TNFRSF11B
45	dexamethasone32 42 34 9 9	10.4	SERPINE1, RETN, VWF, BMP6, LEP, FN1
46	creatinine32	6.3	TNFRSF11B, DNAH8, THBD, AGER, EDN1, IGFBP3
47	cholesterol32 9 18 9	9.2	RETN, LEP, AOC3, CCL2, TNFRSF11B, PDGFRB
48	serine32	5.2	LIPC, PDGFRB, AGER, DYT10, LEP, FN1
49	cycloheximide32	5.0	ADM, SOD2, THBD, EDN1, APOE, DYT10
50	vegf32	4.4	ADM, SOD2, THBD, AGER, EDN1, PDGFRB

Cellular components related to diabetic angiopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	9.6	VWF, SERPINE1, FN1, IGFBP7
2	platelet alpha granule lumen	GO:031093	9.4	FN1, SERPINE1, VWF
3	extracellular region	GO:005576	6.2	CCL2, IGFBP3, TNFRSF11B, EDN1, AGER, ADM
4	extracellular space	GO:005615	6.1	SELE, ADM, THBD, EDN1, TNFRSF11B, IGFBP3

Biological processes related to diabetic angiopathy according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	response to reactive oxygen species	GO:000302	10.4	SERPINE1
2	maternal process involved in parturition	GO:060137	10.1	CCL2, EDN1
3	positive regulation of mitosis	GO:045840	10.1	INS, PDGFRB, EDN1
4	response to lipopolysaccharide	GO:032496	10.0	ADM, THBD, EDN1, SELE
5	response to wounding	GO:009611	10.0	ADM, AGER, FN1, VWF
6	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	INS, CAT, PDGFRB
7	negative regulation of vasoconstriction	GO:045906	9.7	LEP, ADM
8	negative regulation of blood coagulation	GO:030195	9.6	SERPINE1, APOE, EDN1, THBD
9	positive regulation of insulin receptor signaling pathway	GO:046628	9.5	INS, LEP
10	chylomicron remnant clearance	GO:034382	9.4	APOE, LIPC
11	cellular response to lipopolysaccharide	GO:071222	9.3	SERPINE1, CCL2, NOS2
12	inflammatory response	GO:006954	9.3	AGER, CCL2, AOC3, BMP6, SELE
13	cholesterol metabolic process	GO:008203	9.1	CAT, APOE, LEP, LIPC
14	negative regulation of apoptotic process	GO:043066	9.0	SOD2, CAT, INS, LEP, SERPINE1
15	response to hypoxia	GO:001666	8.7	ADM, EDN1, NOS2, CAT, CCL2, LEP

Molecular functions related to diabetic angiopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:002020	9.7	VWF, SERPINE1, INS
2	hormone activity	GO:005179	9.1	RETN, LEP, INS, EDN1, ADM
3	heparin binding	GO:008201	8.9	CCL2, APOE, FN1, LIPC
4	receptor binding	GO:005102	8.6	ADM, PDGFRB, NOS2, CAT, CCL2, SERPINE1