MCID: DBT008
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Diabetic Angiopathy malady

Cardiovascular diseases category

Summaries for Diabetic Angiopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic angiopathy is a form of angiopathy associated with diabetes mellitus. While not exclusive, the... more...

MalaCards: Diabetic Angiopathy, also known as diabetic angiopathies, is related to neuropathy and pancreatitis. An important gene associated with Diabetic Angiopathy is AGER (advanced glycosylation end product-specific receptor), and among its related pathways are Platelet activation, signaling and aggregation and superoxide radicals degradation. The drug pentoxifylline and the compounds estrogen and superoxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, thyroid and monocytes, and related mouse phenotypes are reproductive system and integument.

Aliases & Classifications for Diabetic Angiopathy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

diabetic angiopathy 8 10
diabetic angiopathies 44 60
diabetic vascular disorder 8


External Ids:

Disease Ontology8 DOID:11713
MeSH34 D003925
NCIt39 C35610

Related Diseases for Diabetic Angiopathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Angiopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy30.4INS, SOD2
2pancreatitis30.0INS, SOD2
3vasculitis30.0SELE, THBD, FN1, CCL2
4diabetic retinopathy30.0ADM, SERPINE1, NOS2, INS, NAGLU, FN1
5diabetic nephropathy30.0ADM, SERPINE1, THBD, INS, NAGLU, FN1
6hyperglycemia30.0SERPINE1, SELE, NOS2, INS, NAGLU, RETN
7vascular disease30.0SERPINE1, SELE, NOS2, THBD, INS, RETN
8diabetes mellitus30.0SERPINE1, SELE, THBD, INS, NAGLU, RETN
9diabetic neuropathy10.3
10autoimmune thyroiditis10.0
11diabetic peripheral angiopathy10.0
12thyroiditis10.0
13nephrotic syndrome10.0NAGLU
14eclampsia10.0THBD
15lupus erythematosus10.0THBD
16cerebrovascular disease10.0ADM
17lung cancer10.0FN1
18dilated cardiomyopathy10.0EDN1
19graves' disease10.0SELE
20blindness10.0INS
21pheochromocytoma10.0ADM
22morbid obesity10.0INS
23acute pancreatitis10.0RETN
24nephrosclerosis10.0ADM
25meningitis10.0CAT
26viral hepatitis10.0FN1
27myopathy10.0INS
28pneumoconiosis10.0CAT
29portal hypertension10.0EDN1
30gingivitis10.0TNFRSF11B
31hepatopulmonary syndrome10.0EDN1
32dermatitis10.0SELE
33choriocarcinoma10.0ADM
34cushing's syndrome10.0INS
35vesicoureteral reflux10.0NAGLU
36urticaria10.0SELE
37pyelonephritis10.0NAGLU
38cataract10.0CAT
39osteomyelitis10.0CAT
40multiple myeloma10.0TNFRSF11B
41age related macular degeneration10.0LIPC
42myeloid leukemia10.0FN1
43wilson disease10.0CAT
44thrombocytopenia10.0THBD
45hyperparathyroidism10.0TNFRSF11B
46cystitis10.0NAGLU
47hyperuricemia10.0INS
48hepatitis c10.0SOD2
49retinal detachment10.0FN1
50oligohydramnios10.0NAGLU

Graphical network of the top 20 diseases related to Diabetic Angiopathy:



Diseases related to diabetic angiopathy

Clinical Features for Diabetic Angiopathy

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Drugs & Therapeutics for Diabetic Angiopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Angiopathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Angiopathy

Search NIH Clinical Center for Diabetic Angiopathy

Search CenterWatch for Diabetic Angiopathy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Diabetic Angiopathy

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Anatomical Context for Diabetic Angiopathy

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32MalaCards
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MalaCards organs/tissues related to Diabetic Angiopathy:

32
Endothelial, Thyroid, Monocytes, Pancreatic islet

Animal Models for Diabetic Angiopathy or affiliated genes

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36MGI
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Publications for Diabetic Angiopathy

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50PubMed
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Articles related to Diabetic Angiopathy:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
The oxidative modification of von Willebrand factor is associated with thrombotic angiopathies in diabetes mellitus. (23383177)
2013
2
Aspirin resistance, platelet turnover, and diabetic angiopathy: a 2011 update. (22142668)
2012
3
Diabetic angiopathy and angiogenic defects. (22853690)
2012
4
Peroxynitrite-induced nitration of cyclooxygenase-2 and inducible nitric oxide synthase promotes their binding in diabetic angiopathy. (20607198)
2010
5
Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy. (16428460)
2006
6
Effects of irbesartan on intracellular antioxidant enzyme expression and activity in adolescents and young adults with early diabetic angiopathy. (15983321)
2005
7
Diabetic angiopathy: new experimental and clinical aspects. (15918103)
2005
8
The role of nitric oxide in the development of diabetic angiopathy. (15156413)
2004
9
Angiotensin-converting enzyme gene and the brachial artery endothelial dysfunction in type 2 diabetes without angiopathy]. (15300633)
2004
10
Pathophysiological mechanisms of diabetic angiopathy. (12623164)
2003
11
Growth hormone, insulin-like growth factor and insulin-like growth factor binding protein in young type I diabetes patients with the onset of diabetic angiopathy]. (12868196)
2003
12
Advanced glycation end products in adolescents and young adults with diabetic angiopathy. (10955941)
2000
13
Plasminogen activator inhibitor-1 and apolipoprotein E gene polymorphisms and diabetic angiopathy. (10809802)
2000
14
Circulating IGF-I and its protective role in the pathogenesis of diabetic angiopathy. (10651746)
2000
15
Growth hormone, IGF-I and diabetic angiopathy revisited. (10651747)
2000
16
Pathophysiologic aspects of diabetic angiopathy]. (10421989)
1999
17
Controversies on the pathogenesis of diabetic angiopathy: which treatment for normotensive adolescents with microalbuminuria and type 1 diabetes? (9642665)
1998
18
Urinary free cortisol and its nyctohemeral variation in adolescents and young adults with IDDM: relation to endothelin 1 and indices of diabetic angiopathy. (11517960)
1998
19
Molecular mechanisms of diabetic angiopathy--clues for innovative therapeutic interventions. (9676989)
1998
20
The role of hyperglycemia and hyperinsulinemia in the pathogenesis of diabetic angiopathy. (8905209)
1996
21
Angiopathy affects circulating endothelin-1 levels in type 2 diabetic patients. (8750766)
1995
22
The results of a comparative study of the lipid peroxidation processes and of the malondialdehyde level of the blood cells in patients with diabetic angiopathies and during insulin therapy]. (7863440)
1994
23
Coagulation and fibrinolytic parameters in patients with various angiopathies--analysis in cerebral thrombosis, diabetic and vasculitic neuropathies]. (8403679)
1993
24
Effect of propionyl-L-carnitine in the treatment of diabetic angiopathy: controlled double blind trial versus placebo. (1644013)
1992
25
The effect of vitamin C on the lipolytic activity in type-II diabetics with angiopathy]. (2069272)
1991
26
Acupuncture in the treatment of diabetic angiopathy of the lower extremities]. (1788185)
1991
27
Lack of correlation of glycosylated haemoglobin level with the duration of diabetes or diabetic angiopathy. (3767198)
1986
28
Trial of repeated low-dose aspirin in diabetic angiopathy. (3092890)
1986
29
Diabetic angiopathy--its lessons in vascular physiology. (356570)
1978
30
Fragmentation haemolysis in patients with severe diabetic angiopathy. (974041)
1976
31
Wound healing: a model for the study of diabetic angiopathy. (971788)
1976
32
Rheographic estimation of peripheral diabetic angiopathy. (1131183)
1975
33
The use of photopletysmography in the diagnosis of diabetic angiopathy. (4416574)
1974
34
Hypothesis: the role of vitamin C in diabetic angiopathy. (4813116)
1974
35
Growth hormoe and diabetic angiopathy. (4720360)
1973
36
Diabetic angiopathy and blood viscosity (author's transl)]. (4793677)
1973
37
Immunologic aspects of diabetic angiopathy: does thyroid autoimmunity play an etiologic role in some forms of diabetic vasculitis? (4261532)
1971
38
The pathogenesis of diabetic angiopathy and growth hormone. (4942397)
1971
39
Do any changes similar to those in the basal membrane occur in other parts of the organism and could they be used for the early diagnosis of diabetes and diabetic angiopathy? (5146910)
1971
40
Diabetes, diabetic angiopathy, and growth hormone. (4194508)
1970
41
Diabetes, diabetic angiopathy, and growth hormone. (4194734)
1970
42
Growth hormone and diabetic angiopathy. (4195153)
1970
43
Diabetic angiopathy and sulfonylurea therapy. (5697884)
1968
44
A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. IV. Diabetic retinal angiopathy. (5684307)
1968
45
Diabetic angiopathy and L-xylulose. (5953445)
1966
46
Diabetic angiopathy (pathological findings). (5213746)
1965
47
HYPOPHYSEO-ADRENAL FUNCTION IN DIABETIC ANGIOPATHY. (14175499)
1964
48
ELECTROMYOGRAPHIC STUDY IN DIABETES: CONTRIBUTION TO THE PROBLEM OF DIABETIC ANGIOPATHY. (14206340)
1964
49
Hypophysectomy for diabetic angiopathy. A preliminary report. (13931672)
1962
50
Diabetic angiopathy: a specific vascular disease. (13131862)
1954

Genetic Variations for Diabetic Angiopathy

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Expression for genes affiliated with Diabetic Angiopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Angiopathy

Search GEO for disease gene expression data for Diabetic Angiopathy.

Pathways for genes affiliated with Diabetic Angiopathy

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Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Diabetic Angiopathy

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Diabetic Angiopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6LIPC
2superoxide44 2411.5CCL2
3cycloheximide4410.5SOD2, CAT
4uric acid44 2411.5SERPINE1
5norepinephrine44 11 2412.4ADM, RETN
6pge24410.2FN1
7nadph44 2411.1NAGLU, SOD2, ADM, PDGFRB
8glucose449.8ADM, THBD, NAGLU, IGFBP7, IGFBP3, PDGFRB
9heparin44 28 11 2412.7NAGLU, TNFRSF11B, LIPC, SELE, AGER, FN1
10probucol44 1110.7CAT, CCL2, EDN1, LIPC, SELE
11endotoxin449.7ADM, SERPINE1, SELE, THBD, RETN
12losartan44 49 28 1112.7ADM, SELE, IGFBP3, EDN1, THBD, SERPINE1
13dexamethasone44 49 28 1112.7SOD2, TNFRSF11B, FN1, RETN, INS
14polymyxin b449.6SELE, CCL2, SERPINE1, TNFRSF11B, THBD
15malondialdehyde449.6CAT, AOC3, AGER, NAGLU, ADM, SOD2
16h2o2449.5THBD, AOC3, PDGFRB, CAT, NAGLU
17aspartate449.5CCL2, IGFBP3, RETN, NAGLU, SELE
18vitamin a44 11 2411.5NAGLU, CAT, RETN, SOD2, LIPC
19nitroglycerin44 1110.5NOS2, ADM, EDN1, TNFRSF11B, SOD2
20thiazolidinedione449.4INS, SERPINE1, CCL2, THBD, RETN
21ang ii449.4NOS2, CCL2, EDN1, ADM, PDGFRB
22c-peptide449.3NAGLU, SERPINE1, INS, LIPC, IGFBP3, RETN
23fenofibrate44 49 1111.3RETN, INS, SELE, LIPC, CCL2, SERPINE1
24p003449.3ADM, SERPINE1, IGFBP3, LIPC, AOC3, RETN
25pioglitazone44 49 28 1112.2INS, RETN, CCL2, FN1, SERPINE1, LIPC
26cyclosporin a44 28 5911.2TNFRSF11B, EDN1, LIPC, NAGLU, IGFBP3, FN1
27sodium nitroprusside449.2CAT, NOS2, ADM, SERPINE1, EDN1, SOD2
28serine449.2TNFRSF11B, FN1, IGFBP7, SELE, CCL2, AGER
29homocysteine44 2410.1THBD, SERPINE1, ADM, SELE, NAGLU, RETN
308-isoprostane449.1CCL2, CAT, EDN1, RETN, INS, THBD
31oxygen44 2410.1LIPC, RETN, ADM, AOC3, CCL2, NAGLU
32lactate449.1SELE, SOD2, NAGLU, INS, IGFBP3, THBD
33isoproterenol44 1110.1SERPINE1, SELE, NOS2, RETN, CCL2, EDN1
34sb 20358044 5910.0EDN1, NOS2, SELE, SERPINE1, FN1, CCL2
35atorvastatin44 49 28 11 2413.0SELE, LIPC, EDN1, TNFRSF11B, CCL2, THBD
36creatinine448.9AOC3, TNFRSF11B, AGER, IGFBP3, SELE, THBD
37prostacyclin448.9IGFBP7, AGER, CCL2, EDN1, FN1, THBD
38vitamin d448.8IGFBP3, TNFRSF11B, SERPINE1, CCL2, SOD2, FN1
39genistein44 28 59 2 11 2413.8FN1, TNFRSF11B, NOS2, SERPINE1, CCL2, SOD2
40fibrinogen448.8THBD, CCL2, SERPINE1, SELE, INS, RETN
41epinephrine44 11 2410.6INS, AOC3, ADM, EDN1, IGFBP3, SOD2
42alanine448.6FN1, SOD2, ADM, PDGFRB, SELE, IGFBP3
43arginine448.5NOS2, CCL2, THBD, FN1, ADM, INS
44actinomycin d448.4CAT, EDN1, FN1, RETN, THBD, NOS2
45testosterone44 59 11 2411.3TNFRSF11B, ADM, SERPINE1, SELE, RETN, IGFBP3
46ly294002448.2PDGFRB, TNFRSF11B, IGFBP3, FN1, RETN, INS
47cholesterol44 28 11 2410.7INS, TNFRSF11B, AOC3, AGER, ADM, IGFBP3
48lipid447.6CAT, NAGLU, INS, THBD, SELE, SOD2
49vegf447.6ADM, SERPINE1, SELE, NOS2, THBD, RETN
50nitric oxide44 11 249.6CCL2, CAT, SOD2, SERPINE1, SELE, NOS2

GO Terms for genes affiliated with Diabetic Angiopathy

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16Gene Ontology
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Cellular components related to Diabetic Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.2SERPINE1, INS, RETN, FN1, IGFBP3, AGER
2extracellular spaceGO:0056157.5CCL2, SELE, INS, RETN, FN1, IGFBP7

Biological processes related to Diabetic Angiopathy according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of blood coagulationGO:03019510.2EDN1, THBD, SERPINE1
2positive regulation of mitosisGO:04584010.2PDGFRB, EDN1, INS
3response to woundingGO:00961110.2ADM, FN1, AGER
4response to hyperoxiaGO:05509310.1PDGFRB, SOD2, CAT
5positive regulation of vasodilationGO:04590910.1INS, NOS2, ADM
6maternal process involved in parturitionGO:06013710.1CCL2, EDN1
7positive regulation of heart rateGO:01046010.1ADM, EDN1
8positive regulation of nitric oxide biosynthetic processGO:04542910.1EDN1, INS, SOD2
9positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1CAT, PDGFRB, INS
10negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:190217610.1INS, SOD2
11response to lipopolysaccharideGO:03249610.0ADM, SOD2, SELE, EDN1
12negative regulation of smooth muscle cell migrationGO:0149129.8SERPINE1, IGFBP3
13negative regulation of fibrinolysisGO:0519189.8THBD, SERPINE1
14cellular response to lipopolysaccharideGO:0712229.7SERPINE1, NOS2, CCL2
15blood coagulationGO:0075969.5SELE, NOS2, THBD, FN1, SERPINE1
16inflammatory responseGO:0069549.5SELE, NOS2, AGER, AOC3, CCL2
17response to hypoxiaGO:0016669.5ADM, NOS2, EDN1, SOD2, CAT, CCL2

Molecular functions related to Diabetic Angiopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.6ADM, INS, RETN, EDN1
2receptor bindingGO:0051028.8ADM, CCL2, CAT, PDGFRB, NOS2, SERPINE1

Products for genes affiliated with Diabetic Angiopathy

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Sources for Diabetic Angiopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet