MCID: DBT002
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Diabetic Autonomic Neuropathy malady

Neuronal diseases category

Summaries for Diabetic Autonomic Neuropathy

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32MalaCards
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MalaCards: Diabetic Autonomic Neuropathy is related to neuropathy and diabetic neuropathy. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are HIF-1 signaling pathway and PI3K-Akt signaling pathway. The compounds norepinephrine and em 523 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and skin, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Diabetic Autonomic Neuropathy

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

diabetic autonomic neuropathy 8 44 60


External Ids:

Disease Ontology8 DOID:11503
NCIt39 C27068
SNOMED-CT56 50620007
MeSH34 D003929

Related Diseases for Diabetic Autonomic Neuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.0AKR1B1, NTF3, INS, NGF
2diabetic neuropathy32.0INS, NTF3, AKR1B1, NGF
3autonomic neuropathy31.9AKR1B1, MLN, NTF3, EPO, NGF, INS
4pancreatitis30.8INS, GCG
5hypoglycemia30.7IGF1, INS, GAST, GCG, MLN, AKR1B1
6myocardial infarction30.4AKR1B1, GCG
7hypertension30.4IGF1, INS
8neuroblastoma30.1NGF
9esophagitis30.1GAST
10neuroaxonal dystrophy30.1NGF, NTF3
11acute myocardial infarction30.1GCG
12pheochromocytoma30.1NGF, NTF3, MLN
13vascular disease30.1AKR1B1, NGF, INS
14obesity30.1AKR1B1, IGF1, GCG, INS, MLN
15diabetes mellitus30.1NGF, INS, GCG, AKR1B1, MLN, IGF1
16autonomic peripheral neuropathy10.4
17iritis10.4
18peripheral neuropathy10.4
19axonal neuropathy10.3
20diabetic foot ulcers10.1
21reflex sympathetic dystrophy10.1
22gastric dilatation10.1
23cerebritis10.1
24motor peripheral neuropathy10.1
25type 1 diabetes mellitus10.1
26polyneuropathy10.0AKR1B1
27liver cirrhosis10.0MLN
28irritable bowel syndrome10.0MLN
29constipation10.0MLN
30parkinson's disease10.0NGF
31motor neuron disease10.0NTF3
32hydrocephalus10.0NTF3
33dermatitis10.0NTF3
34atopic dermatitis10.0NGF
35multiple endocrine neoplasia10.0GAST
36gastroduodenitis10.0GAST
37duodenitis10.0GAST
38eye disease10.0NGF
39pancreatic islet cell tumors10.0GAST
40pyloric stenosis10.0GAST
41malignant glioma10.0NTF3
42eating disorder10.0INS
43peptic ulcer10.0GAST
44gastric ulcer10.0GAST
45paraganglioma10.0GAST
46cushing's syndrome10.0INS
47stroke, ischemic10.0INS
48pallister-hall syndrome10.0HCN3
49somatostatinoma10.0GAST
50donohue syndrome10.0INS

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to diabetic autonomic neuropathy

Clinical Features for Diabetic Autonomic Neuropathy

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Drugs & Therapeutics for Diabetic Autonomic Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Autonomic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Autonomic Neuropathy

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Search CenterWatch for Diabetic Autonomic Neuropathy

Genetic Tests for Diabetic Autonomic Neuropathy

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Anatomical Context for Diabetic Autonomic Neuropathy

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32MalaCards
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MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

32
Heart, Testes, Skin, Bone marrow, Lung, Colon, Spinal cord, Brain, Bone, Eye, Pancreatic islet, Adrenal gland

Animal Models for Diabetic Autonomic Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3IGF1, HCN3, NGF, EPO, INS, NTF3
2MP:00053767.0INS, GCG, GAST, AKR1B1, NTF3, IGF1
3MP:00107686.8GCG, GAST, AKR1B1, NTF3, IGF1, NGF

Publications for Diabetic Autonomic Neuropathy

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50PubMed
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Articles related to Diabetic Autonomic Neuropathy:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Mesenchymal stem cell therapy improves diabetic cardiac autonomic neuropathy and decreases the inducibility of ventricular arrhythmias. (23850388)
2013
2
Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients. (20130937)
2012
3
Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. (22306250)
2012
4
What do we know and we do not know about cardiovascular autonomic neuropathy in diabetes. (22644723)
2012
5
Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. (21695768)
2011
6
Squatting, a posture test for studying cardiovascular autonomic neuropathy in diabetes. (22071282)
2011
7
Pulse wave analysis and cardiac autonomic neuropathy in type 1 diabetes: a report from the Pittsburgh Epidemiology of Diabetes Complications Study. (21819228)
2011
8
Using dynamic pupillometry as a simple screening tool to detect autonomic neuropathy in patients with diabetes: a pilot study. (20565794)
2010
9
Pulse pressure and cardiovascular autonomic neuropathy according to duration of type 1 diabetes. (19437445)
2009
10
Cardiovascular autonomic neuropathy in diabetes mellitus. (21179924)
2009
11
A pharmacologic pupillary test in the diagnosis of diabetic autonomic neuropathy. (20046691)
2009
12
Is erectile dysfunction a sentinel symptom for cardiovascular autonomic neuropathy in patients with type 2 diabetes? (18211294)
2008
13
Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes. (18837735)
2008
14
Heart rate variability modifications following exercise training in type 2 diabetic patients with definite cardiac autonomic neuropathy. (17526623)
2008
15
Cardiac autonomic neuropathy predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy. (16443883)
2006
16
Prognostic value of cardiac autonomic neuropathy independent and incremental to perfusion defects in patients with diabetes and suspected coronary artery disease. (14675587)
2003
17
Preclinical diabetic cardiomyopathy: relation of left ventricular diastolic dysfunction to cardiac autonomic neuropathy in men with uncomplicated well-controlled type 2 diabetes. (12898473)
2003
18
Aortic distensibility is reduced in subjects with type 2 diabetes and cardiac autonomic neuropathy. (14636290)
2003
19
Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes. (12196425)
2002
20
Changes of gastric emptying rate and gastrin levels are early indicators of autonomic neuropathy in type II diabetic patients. (11710799)
2001
21
Time- and frequency-domain estimation of early diabetic cardiovascular autonomic neuropathy. (11794718)
2001
22
Gastric myoelectrical activity in diabetics with and without diabetic autonomic neuropathy. (11379361)
2001
23
Autonomic neuropathy--a complication less pronounced in patients with Type 1 diabetes mellitus who have lower blood glucose levels. (11168329)
2000
24
Asymptomatic coronary artery disease is associated with cardiac autonomic neuropathy and diabetic nephropathy in type 2 diabetic patients. (10526747)
1999
25
Diagnosis of cardiac autonomic neuropathy in diabetic patients. (10480798)
1999
26
Long-term effect of epalrestat on cardiac autonomic neuropathy in subjects with non-insulin dependent diabetes mellitus. (10369429)
1999
27
Effects of autonomic neuropathy on counterregulation and awareness of hypoglycemia in type 1 diabetic patients. (9802751)
1998
28
Diabetic autonomic neuropathy and the heart. (8964191)
1996
29
Correlation of altered Q-T interval and sympathetic nervous system dysfunction in diabetic autonomic neuropathy. (8137835)
1994
30
Day and night variation in ambulatory blood pressure in type 1 diabetes mellitus with nephropathy and autonomic neuropathy. (8433073)
1993
31
Gastrointestinal manifestations of diabetic autonomic neuropathy. (1803244)
1991
32
QT interval in diabetic autonomic neuropathy. (2147640)
1990
33
Diabetic autonomic neuropathy and bladder function: pharmacological use of gangliosides and insulin. (2283091)
1990
34
Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics. (2217668)
1990
35
Response of pancreatic polypeptide to a protein rich meal in diabetic autonomic neuropathy. (2806702)
1989
36
Metabolic and cardiovascular responses to epinephrine in diabetic autonomic neuropathy. (3614285)
1987
37
Standard EKG: a useful screening method for diabetic autonomic neuropathy. (3948642)
1986
38
The effect of domperidone on oesophageal emptying in diabetic autonomic neuropathy. (3994893)
1985
39
Glucose counterregulation in diabetic autonomic neuropathy. (2870835)
1985
40
The prevalence of diabetic autonomic neuropathy indicated by abnormal R-R interval variation. (6096985)
1983
41
Experimental diabetic autonomic neuropathy characterization in streptozotocin-diabetic Sprague-Dawley rats. (6632773)
1983
42
Haemodynamic changes during graded exercise in patients with diabetic autonomic neuropathy. (7095332)
1982
43
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
44
A robust respiration follower for studies of diabetic autonomic neuropathy. (548648)
1979
45
Cardiorespiratory arrest in diabetic autonomic neuropathy. (430789)
1979
46
Pupillary signs in diabetic autonomic neuropathy. (709128)
1978
47
Cardiorespiratory arrest in diabetic autonomic neuropathy. (691180)
1978
48
Painful myocardial infarction in severe diabetic autonomic neuropathy. (707002)
1978
49
The autonomous heart in diabetic autonomic neuropathy. (1036578)
1976
50
Defective innervation of heart in diabetic autonomic neuropathy. (1131653)
1975

Genetic Variations for Diabetic Autonomic Neuropathy

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Expression for genes affiliated with Diabetic Autonomic Neuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for genes affiliated with Diabetic Autonomic Neuropathy

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29KEGG, 53Reactome
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Pathways related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4INS, EPO, IGF1
29.2INS, IGF1, NGF, EPO
3
Hide members
8.2GCG, GAST, MLNR, MLN
4
Hide members
7.2GAST, MLNR, MLN, IGF1, NGF, INS

Compounds for genes affiliated with Diabetic Autonomic Neuropathy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.0GAST, NTF3
2em 523449.7MLN, MLNR
3aminoguanidine44 28 1111.7AKR1B1, AOC1, EPO
4trimebutine449.5MLN, GAST
5ly294002449.5NGF, NTF3, GCG
6gnrh449.5GAST, GCG
7levodopa44 1110.4IGF1, AOC1, NGF, AKR1B1
8ondansetron44 49 11 2412.4GAST, MLN, EPO
9voglibose44 1110.4INS, GCG
10acipimox44 2810.3IGF1, GCG, INS
11vitamin b12449.3AKR1B1, GAST, EPO, IGF1
12streptozotocin449.2GCG, AKR1B1, NTF3, INS
13cisapride44 28 1111.1GCG, MLNR, MLN
14hydrocortisone44 2 59 1112.1IGF1, GAST, EPO, INS
15i-app449.1GCG, INS, GAST
16pirenzepine44 28 1111.0GCG, IGF1, GAST
17bethanechol44 28 1111.0GAST, GCG, MLN
18glycerol44 11 2410.9INS, GCG, AKR1B1, NGF
19oxyntomodulin44 599.9MLN, GAST, GCG
20calcitriol44 59 11 2411.9IGF1, NGF, EPO, GAST
21thyroxine44 249.8IGF1, NGF, INS, MLN, GAST
22thymidine44 249.8IGF1, EPO, GAST, NTF3, NGF
23starch448.8INS, GCG, IGF1, GAST
24carbachol44 28 1110.7NGF, NTF3, GAST, GCG
25genistein44 28 59 2 11 2413.7AKR1B1, GCG, NGF, IGF1, NTF3
26c-peptide448.7INS, IGF1, GCG, GAST
27atropine44 28 1110.7MLN, NGF, GCG, GAST
28acth448.7INS, IGF1, GAST, MLN
29wortmannin448.7GCG, NTF3, INS, NGF, IGF1
30rapamycin448.7INS, EPO, IGF1, NTF3, GCG
31testosterone44 59 11 2411.6GAST, AKR1B1, INS, IGF1, EPO, NGF
32nifedipine44 49 28 1111.6NGF, GCG, GAST, MLN
33nicotinamide44 119.5AKR1B1, EPO, INS, GAST, GCG
34epinephrine44 11 2410.5GAST, AKR1B1, GCG, NGF, INS
35alanine448.5INS, GAST, NGF, MLN, MLNR, AKR1B1
36lactate448.4AOC1, AKR1B1, GCG, INS, EPO
37acetylcholine44 49 28 11 2412.3GCG, GAST, MLN, NGF, NTF3
385-hydroxytryptamine448.3GAST, GCG, AOC1, MLN
39adenylate448.1NGF, MLN, AKR1B1, GAST, NTF3, GCG
40glutamine448.0IGF1, NGF, AOC1, AKR1B1, GAST, GCG
41octreotide44 59 28 1111.0GAST, GCG, MLN, IGF1, EPO, INS
42vegf447.9EPO, NGF, IGF1, GCG, AKR1B1, GAST
43histamine44 28 249.9NTF3, GAST, GCG, NGF, AOC1, MLN
44glutamate447.8GCG, AOC1, NTF3, NGF, GAST, INS
45dopamine44 28 11 2410.6GCG, GAST, MLNR, NTF3, IGF1, NGF
46estrogen447.6AKR1B1, GAST, GCG, INS, IGF1, NTF3
47arginine447.5AOC1, IGF1, NGF, INS, MLN, AKR1B1
48heparin44 28 11 2410.5GCG, NTF3, AOC1, MLN, GAST
49creatinine447.4GAST, EPO, INS, AKR1B1, NGF, IGF1
50glucose447.2GCG, GAST, AKR1B1, INS, MLN, AOC1

GO Terms for genes affiliated with Diabetic Autonomic Neuropathy

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16Gene Ontology
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Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.3INS, GCG
2extracellular spaceGO:0056157.4INS, GCG, AKR1B1, AOC1, IGF1, NGF
3extracellular regionGO:0055766.7INS, GCG, GAST, MLN, NTF3, IGF1

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein autophosphorylationGO:03195410.1INS, NGF
2positive regulation of glycolysisGO:04582110.0INS, IGF1
3response to electrical stimulusGO:05160210.0NGF, EPO
4positive regulation of glycogen biosynthetic processGO:04572510.0INS, IGF1
5positive regulation of Ras protein signal transductionGO:0465799.9EPO, IGF1
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IGF1, EPO
7positive regulation of glucose importGO:0463269.8INS, IGF1
8activation of protein kinase B activityGO:0321489.7INS, NTF3
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7NTF3, IGF1, INS
10positive regulation of DNA replicationGO:0457409.7INS, EPO, IGF1
11positive regulation of mitosisGO:0458409.5INS, IGF1
12positive regulation of cell proliferationGO:0082849.3NTF3, IGF1, EPO, INS
13G-protein coupled receptor signaling pathwayGO:0071868.1INS, MLN, MLNR, GAST, GCG
14signal transductionGO:0071658.0GCG, GAST, NTF3, IGF1, EPO

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:0051589.8INS, IGF1
2insulin-like growth factor receptor bindingGO:0051599.7INS, IGF1
3sodium channel activityGO:0052729.4AOC1, HCN3
4growth factor activityGO:0080839.2NGF, IGF1, NTF3
5hormone activityGO:0051797.6INS, EPO, IGF1, MLN, GAST, GCG

Products for genes affiliated with Diabetic Autonomic Neuropathy

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  • Antibodies
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Sources for Diabetic Autonomic Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet