MCID: DBT002
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Diabetic Autonomic Neuropathy malady

Neuronal diseases category

Summaries for Diabetic Autonomic Neuropathy

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32MalaCards
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MalaCards: Diabetic Autonomic Neuropathy is related to neuropathy and diabetic neuropathy. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are HIF-1 signaling pathway and PI3K-Akt signaling pathway. The compounds norepinephrine and em 523 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and skin, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Diabetic Autonomic Neuropathy

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

diabetic autonomic neuropathy 8 44 60


External Ids:

Disease Ontology8 DOID:11503
NCIt39 C27068
SNOMED-CT56 50620007
MeSH34 D003929

Related Diseases for Diabetic Autonomic Neuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.0AKR1B1, NTF3, INS, NGF
2diabetic neuropathy32.0INS, NTF3, AKR1B1, NGF
3autonomic neuropathy31.9AKR1B1, MLN, NTF3, EPO, NGF, INS
4pancreatitis30.8INS, GCG
5hypoglycemia30.7IGF1, INS, GAST, GCG, MLN, AKR1B1
6myocardial infarction30.4AKR1B1, GCG
7hypertension30.4IGF1, INS
8neuroblastoma30.1NGF
9esophagitis30.1GAST
10neuroaxonal dystrophy30.1NGF, NTF3
11acute myocardial infarction30.1GCG
12pheochromocytoma30.1NGF, NTF3, MLN
13vascular disease30.1AKR1B1, NGF, INS
14obesity30.1AKR1B1, IGF1, GCG, INS, MLN
15diabetes mellitus30.1NGF, INS, GCG, AKR1B1, MLN, IGF1
16autonomic peripheral neuropathy10.4
17iritis10.4
18peripheral neuropathy10.4
19axonal neuropathy10.3
20diabetic foot ulcers10.1
21reflex sympathetic dystrophy10.1
22gastric dilatation10.1
23cerebritis10.1
24motor peripheral neuropathy10.1
25type 1 diabetes mellitus10.1
26polyneuropathy10.0AKR1B1
27liver cirrhosis10.0MLN
28irritable bowel syndrome10.0MLN
29constipation10.0MLN
30parkinson's disease10.0NGF
31motor neuron disease10.0NTF3
32hydrocephalus10.0NTF3
33dermatitis10.0NTF3
34atopic dermatitis10.0NGF
35multiple endocrine neoplasia10.0GAST
36gastroduodenitis10.0GAST
37duodenitis10.0GAST
38eye disease10.0NGF
39pancreatic islet cell tumors10.0GAST
40pyloric stenosis10.0GAST
41malignant glioma10.0NTF3
42eating disorder10.0INS
43peptic ulcer10.0GAST
44gastric ulcer10.0GAST
45paraganglioma10.0GAST
46cushing's syndrome10.0INS
47stroke, ischemic10.0INS
48pallister-hall syndrome10.0HCN3
49somatostatinoma10.0GAST
50donohue syndrome10.0INS

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to diabetic autonomic neuropathy

Clinical Features for Diabetic Autonomic Neuropathy

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Drugs & Therapeutics for Diabetic Autonomic Neuropathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Autonomic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Autonomic Neuropathy

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Search CenterWatch for Diabetic Autonomic Neuropathy

Genetic Tests for Diabetic Autonomic Neuropathy

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Anatomical Context for Diabetic Autonomic Neuropathy

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32MalaCards
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MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

32
Heart, Testes, Skin, Bone marrow, Lung, Colon, Spinal cord, Brain, Bone, Eye, Pancreatic islet, Adrenal gland

Animal Models for Diabetic Autonomic Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3IGF1, HCN3, NGF, EPO, INS, NTF3
2MP:00053767.0INS, GCG, GAST, AKR1B1, NTF3, IGF1
3MP:00107686.8GCG, GAST, AKR1B1, NTF3, IGF1, NGF

Publications for Diabetic Autonomic Neuropathy

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50PubMed
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Articles related to Diabetic Autonomic Neuropathy:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Detection of cardiovascular autonomic neuropathy using exercise testing in patients with type 2 diabetes mellitus. (23083925)
2013
2
Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease. (23550085)
2013
3
Predicting cardiac autonomic neuropathy category for diabetic data with missing values. (24034723)
2013
4
Diabetic autonomic neuropathy. (23393679)
2012
5
Simple function tests for autonomic neuropathy have a higher predictive value on all-cause mortality in diabetes compared to 24-h heart rate variability. (22512975)
2012
6
The ECG vertigo in diabetes and cardiac autonomic neuropathy. (21747831)
2011
7
Autonomic neuropathy and plasma catecholamine in patients with diabetes mellitus. (21528763)
2010
8
Association of cardiac autonomic neuropathy with subclinical myocardial dysfunction in type 2 diabetes. (21163448)
2010
9
Different effects of diabetic autonomic neuropathy on regional transcutaneous oxygen tension in patients with peripheral arterial disease. (21466127)
2010
10
Glucose variability does not contribute to the development of peripheral and autonomic neuropathy in type 1 diabetes: data from the DCCT. (19672575)
2009
11
Heart rate variability and complexity in people with diabetes associated cardiac autonomic neuropathy. (19163764)
2008
12
Impact of autonomic neuropathy on left ventricular function in normotensive type 1 diabetic patients: a tissue Doppler echocardiographic study: response to Karamitsos et al. (18445720)
2008
13
Cardiovascular autonomic neuropathy, autonomic symptoms and diabetic complications in 674 type 2 diabetes. (18824270)
2008
14
Diabetic cardiovascular autonomic neuropathy. (17242296)
2007
15
Usefulness of a new indicator test for the diagnosis of peripheral and autonomic neuropathy in patients with diabetes mellitus. (17941862)
2007
16
Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy. (15333481)
2004
17
The relationship between QTc interval and cardiac autonomic neuropathy in diabetes mellitus. (12956407)
2003
18
Impaired gastric emptying and altered intragastric meal distribution in diabetes mellitus related to autonomic neuropathy? (12822859)
2003
19
Resolution of diabetic autonomic neuropathy. (12151692)
2002
20
Role of heart rate variability in the early diagnosis of diabetic autonomic neuropathy in children. (12574897)
2002
21
Diabetic autonomic neuropathy causing gall bladder dysfunction. (11848318)
2001
22
Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent myocardial ischemia. (11213889)
2001
23
Impairment of the respiratory system in diabetic autonomic neuropathy. (10963393)
2000
24
Assessing cardiovascular autonomic neuropathy in diabetes mellitus: how many tests to use? (10925060)
2000
25
Plasma epinephrine and norepinephrine response to stimuli in autonomic neuropathy of type 2 diabetes mellitus. (11194927)
2000
26
Does autonomic neuropathy influence spinal cord stimulation therapy success in diabetic patients with critical lower limb ischemia? (10713199)
2000
27
Noninvasive exploration of cardiac autonomic neuropathy. Four reliable methods for diabetes? (10097915)
1999
28
System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. (10070154)
1999
29
Proximal gastric motor activity in response to a liquid meal in type I diabetes mellitus with autonomic neuropathy. (9539642)
1998
30
Optimal parameters of short-term heart rate spectrogram for routine evaluation of diabetic cardiovascular autonomic neuropathy. (9696273)
1998
31
Autonomic neuropathy and cardiovascular risk factors in insulin-dependent and non insulin-dependent diabetes. (9069569)
1997
32
The splanchnic circulation and postural hypotension in diabetic autonomic neuropathy. (7648826)
1995
33
Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations. (7729794)
1995
34
Licorice ameliorates postural hypotension caused by diabetic autonomic neuropathy. (7821181)
1994
35
Relationship between the circadian rhythms of blood pressure and sympathovagal balance in diabetic autonomic neuropathy. (8243821)
1993
36
Heartbeat and arrhythmia perception in diabetic autonomic neuropathy. (1715091)
1991
37
Cystometric changes in alloxan diabetic rats: evidence for functional and structural correlates of diabetic autonomic neuropathy. (2348050)
1990
38
Evaluation of oral cisapride and metoclopramide in diabetic autonomic neuropathy: an eight-week double-blind crossover study. (2491459)
1989
39
Diabetic autonomic neuropathy: the prevalence of impaired heart rate variability in a geographically defined population. (2522369)
1989
40
Skin microvascular reflexes in patients with diabetic autonomic neuropathy. (3167651)
1988
41
Standing to lying heart rate variation. A new simple test in the diagnosis of diabetic autonomic neuropathy. (2951218)
1987
42
Diabetic autonomic neuropathy. (3773726)
1986
43
Diabetic autonomic neuropathy in the BB rat. Ultrastructural and morphometric changes in sympathetic nerves. (4007283)
1985
44
Diabetic autonomic neuropathy. The distribution of structural changes in sympathetic nerves of the BB rat. (4050972)
1985
45
Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies. (6761211)
1982
46
Tests of cardiovascular reflex function in diabetic autonomic neuropathy. (6929779)
1980
47
Diabetic autonomic neuropathy. The diagnostic value of heart rate monitoring. (7418957)
1980
48
The natural history of diabetic autonomic neuropathy. (7433630)
1980
49
Cardiorespiratory arrest and diabetic autonomic neuropathy. (74496)
1978
50
Total cardiac denervation in diabetic autonomic neuropathy. (955302)
1976

Genetic Variations for Diabetic Autonomic Neuropathy

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Expression for genes affiliated with Diabetic Autonomic Neuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for genes affiliated with Diabetic Autonomic Neuropathy

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29KEGG, 53Reactome
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Pathways related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4INS, EPO, IGF1
29.2IGF1, NGF, EPO, INS
3
Hide members
8.2MLN, MLNR, GAST, GCG
4
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7.2GCG, GAST, MLNR, MLN, IGF1, NGF

Compounds for genes affiliated with Diabetic Autonomic Neuropathy

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.0GAST, NTF3
2em 523449.7MLN, MLNR
3aminoguanidine44 28 1111.7AKR1B1, AOC1, EPO
4trimebutine449.5MLN, GAST
5ly294002449.5NGF, NTF3, GCG
6gnrh449.5GAST, GCG
7levodopa44 1110.4IGF1, AOC1, NGF, AKR1B1
8ondansetron44 49 11 2412.4GAST, MLN, EPO
9voglibose44 1110.4INS, GCG
10acipimox44 2810.3IGF1, GCG, INS
11vitamin b12449.3AKR1B1, GAST, EPO, IGF1
12streptozotocin449.2GCG, AKR1B1, NTF3, INS
13cisapride44 28 1111.1GCG, MLNR, MLN
14hydrocortisone44 2 59 1112.1IGF1, GAST, EPO, INS
15i-app449.1GCG, INS, GAST
16pirenzepine44 28 1111.0GCG, IGF1, GAST
17bethanechol44 28 1111.0GAST, GCG, MLN
18glycerol44 11 2410.9INS, GCG, AKR1B1, NGF
19oxyntomodulin44 599.9MLN, GAST, GCG
20calcitriol44 59 11 2411.9IGF1, NGF, EPO, GAST
21thyroxine44 249.8IGF1, NGF, INS, MLN, GAST
22thymidine44 249.8IGF1, EPO, GAST, NTF3, NGF
23starch448.8INS, GCG, IGF1, GAST
24carbachol44 28 1110.7NGF, NTF3, GAST, GCG
25genistein44 28 59 2 11 2413.7AKR1B1, GCG, NGF, IGF1, NTF3
26c-peptide448.7INS, IGF1, GCG, GAST
27atropine44 28 1110.7MLN, NGF, GCG, GAST
28acth448.7INS, IGF1, GAST, MLN
29wortmannin448.7GCG, NTF3, INS, NGF, IGF1
30rapamycin448.7INS, EPO, IGF1, NTF3, GCG
31testosterone44 59 11 2411.6GAST, AKR1B1, INS, IGF1, EPO, NGF
32nifedipine44 49 28 1111.6NGF, GCG, GAST, MLN
33nicotinamide44 119.5AKR1B1, EPO, INS, GAST, GCG
34epinephrine44 11 2410.5GAST, AKR1B1, GCG, NGF, INS
35alanine448.5INS, GAST, NGF, MLN, MLNR, AKR1B1
36lactate448.4AOC1, AKR1B1, GCG, INS, EPO
37acetylcholine44 49 28 11 2412.3GCG, GAST, MLN, NGF, NTF3
385-hydroxytryptamine448.3GAST, GCG, AOC1, MLN
39adenylate448.1NGF, MLN, AKR1B1, GAST, NTF3, GCG
40glutamine448.0IGF1, NGF, AOC1, AKR1B1, GAST, GCG
41octreotide44 59 28 1111.0GAST, GCG, MLN, IGF1, EPO, INS
42vegf447.9EPO, NGF, IGF1, GCG, AKR1B1, GAST
43histamine44 28 249.9NTF3, GAST, GCG, NGF, AOC1, MLN
44glutamate447.8GCG, AOC1, NTF3, NGF, GAST, INS
45dopamine44 28 11 2410.6GCG, GAST, MLNR, NTF3, IGF1, NGF
46estrogen447.6AKR1B1, GAST, GCG, INS, IGF1, NTF3
47arginine447.5AOC1, IGF1, NGF, INS, MLN, AKR1B1
48heparin44 28 11 2410.5GCG, NTF3, AOC1, MLN, GAST
49creatinine447.4GAST, EPO, INS, AKR1B1, NGF, IGF1
50glucose447.2GCG, GAST, AKR1B1, INS, MLN, AOC1

GO Terms for genes affiliated with Diabetic Autonomic Neuropathy

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16Gene Ontology
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Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.3INS, GCG
2extracellular spaceGO:0056157.4INS, GCG, AKR1B1, AOC1, IGF1, NGF
3extracellular regionGO:0055766.7GCG, GAST, MLN, NTF3, IGF1, NGF

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein autophosphorylationGO:03195410.1INS, NGF
2positive regulation of glycolysisGO:04582110.0INS, IGF1
3response to electrical stimulusGO:05160210.0NGF, EPO
4positive regulation of glycogen biosynthetic processGO:04572510.0INS, IGF1
5positive regulation of Ras protein signal transductionGO:0465799.9EPO, IGF1
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IGF1, EPO
7positive regulation of glucose importGO:0463269.8INS, IGF1
8activation of protein kinase B activityGO:0321489.7INS, NTF3
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7NTF3, IGF1, INS
10positive regulation of DNA replicationGO:0457409.7INS, EPO, IGF1
11positive regulation of mitosisGO:0458409.5INS, IGF1
12positive regulation of cell proliferationGO:0082849.3NTF3, IGF1, EPO, INS
13G-protein coupled receptor signaling pathwayGO:0071868.1INS, MLN, MLNR, GAST, GCG
14signal transductionGO:0071658.0GCG, GAST, NTF3, IGF1, EPO

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:0051589.8INS, IGF1
2insulin-like growth factor receptor bindingGO:0051599.7INS, IGF1
3sodium channel activityGO:0052729.4AOC1, HCN3
4growth factor activityGO:0080839.2NGF, IGF1, NTF3
5hormone activityGO:0051797.6INS, EPO, IGF1, MLN, GAST, GCG

Products for genes affiliated with Diabetic Autonomic Neuropathy

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  • Antibodies
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Sources for Diabetic Autonomic Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet