MCID: DBT002
MIFTS: 40

Diabetic Autonomic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Autonomic Neuropathy

MalaCards integrated aliases for Diabetic Autonomic Neuropathy:

Name: Diabetic Autonomic Neuropathy 12 52 14 69
Diabetic Neuropathies 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11503
MeSH 42 D003929
NCIt 47 C27068
SNOMED-CT 64 50620007
UMLS 69 C0271686

Summaries for Diabetic Autonomic Neuropathy

MalaCards based summary : Diabetic Autonomic Neuropathy, also known as diabetic neuropathies, is related to diabetic neuropathy and microvascular complications of diabetes 1, and has symptoms including neuralgia and sciatica. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are Tyrosine metabolism and p75(NTR)-mediated signaling. The drugs Quinapril and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and skin, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Diabetic Autonomic Neuropathy

Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 diabetic neuropathy 12.4
2 microvascular complications of diabetes 1 11.3
3 autonomic neuropathy 10.9
4 neuropathy 10.9
5 retinitis pigmentosa 17 10.5 AKR1B1 INS
6 ulcerative blepharitis 10.4 EPO INS
7 breast fibroadenoma 10.4 INS NTF3
8 conjunctival vascular disease 10.4 EPO INS
9 vernal conjunctivitis 10.3 AKR1B1 INS
10 postural hypotension 10.2
11 calcinosis 10.1 EPO INS
12 citrullinemia, adult-onset type ii 10.1 AKR1B1 INS
13 hypoglycemia 10.1
14 pancreatitis 10.1
15 repetitive stress injuries 10.0 DBH INS
16 senile angioma 10.0 NGF NTF3
17 sudden cardiac death 9.9
18 iritis 9.9
19 broad ligament malignant neoplasm 9.9 DBH EPO
20 pauci-immune glomerulonephritis with anca 9.9 DBH INS
21 pancreatic acinar cell adenocarcinoma 9.9 INS NGF
22 pyogenic arthritis, pyoderma gangrenosum and acne 9.9 DBH EPO
23 intramuscular hemangioma 9.8 EPO INS
24 chronic lacrimal gland enlargement 9.8 AKR1B1 NGF NTF3
25 myocardial infarction 9.8
26 fuchs' heterochromic uveitis 9.8 AOC1 NGF
27 nephronophthisis 2, infantile 9.7 DBH NGF
28 insulin-like growth factor i 9.7
29 reflex sympathetic dystrophy 9.7
30 cardiomyopathy 9.7
31 acute myocardial infarction 9.7
32 autonomic dysfunction 9.7
33 artery disease 9.7
34 dysautonomia 9.7
35 peripheral artery disease 9.7
36 hypoxia 9.7
37 atrial fibrillation 9.7
38 mucositis 9.7
39 esophagitis 9.7
40 pheochromocytoma 9.7
41 vascular disease 9.7
42 neuroblastoma 9.7
43 gastric dilatation 9.7
44 cerebritis 9.7
45 obesity 9.7
46 fissured tongue 9.5 AKR1B1 EPO INS NGF
47 hemopericardium 9.4 DBH INS NGF
48 parkinson disease, late-onset 9.2 DBH NGF NTF3
49 diffuse large b-cell lymphoma 9.1 AKR1B1 EPO INS NGF NTF3
50 rumination disorder 6.8 AKR1B1 AOC1 DBH EPO INS MLNR

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to Diabetic Autonomic Neuropathy

Symptoms & Phenotypes for Diabetic Autonomic Neuropathy

UMLS symptoms related to Diabetic Autonomic Neuropathy:


neuralgia, sciatica

MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 AOC1 DBH EPO INS NGF NTF3
2 homeostasis/metabolism MP:0005376 9.5 AOC1 DBH EPO INS NGF NTF3
3 vision/eye MP:0005391 9.1 AKR1B1 AOC1 DBH INS NGF NTF3

Drugs & Therapeutics for Diabetic Autonomic Neuropathy

Drugs for Diabetic Autonomic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
2
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
3
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Donepezil Approved Phase 4 120014-06-4 3152
6
Norepinephrine Approved Phase 4 51-41-2 439260
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
gamma-Aminobutyric acid Investigational Phase 4 56-12-2 119
9 HIV Protease Inhibitors Phase 4,Phase 2
10
protease inhibitors Phase 4,Phase 2
11 Hormone Antagonists Phase 4,Phase 2
12 Hormones Phase 4,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
14 Angiotensin-Converting Enzyme Inhibitors Phase 4
15 Antihypertensive Agents Phase 4
16 Analgesics Phase 4,Phase 2
17 Anti-Anxiety Agents Phase 4,Phase 2
18 Anticonvulsants Phase 4,Phase 2
19 calcium channel blockers Phase 4,Phase 2
20 Calcium, Dietary Phase 4,Phase 2
21 Central Nervous System Depressants Phase 4,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 2
23 Psychotropic Drugs Phase 4,Phase 2
24 Tranquilizing Agents Phase 4,Phase 2
25 Neurotransmitter Agents Phase 4
26 Cholinergic Agents Phase 4
27 Cholinesterase Inhibitors Phase 4
28 Antiparkinson Agents Phase 4
29 Dopamine Agents Phase 4
30 Dopamine agonists Phase 4
31 Nootropic Agents Phase 4
32 Antidepressive Agents Phase 4
33 Antimanic Agents Phase 4
34 Duloxetine Hydrochloride Phase 4
35 Excitatory Amino Acid Antagonists Phase 4
36 Excitatory Amino Acids Phase 4
37 GABA Agents Phase 4
38 Neurotransmitter Uptake Inhibitors Phase 4
39
Serotonin Phase 4 50-67-9 5202
40 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
41
Allopurinol Approved Phase 3 315-30-0 2094
42
Zinc Approved Phase 3 7440-66-6 32051 23994
43
Rosiglitazone Approved, Investigational Phase 3 122320-73-4 77999
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
45
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
46
Nicotinamide Approved, Nutraceutical Phase 3 98-92-0 936
47 Hypoglycemic Agents Phase 3,Phase 2
48 Antimetabolites Phase 3
49 Antioxidants Phase 3
50 Antirheumatic Agents Phase 3

Interventional clinical trials:

(show all 39)

id Name Status NCT ID Phase Drugs
1 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
2 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
3 Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study Completed NCT00466778 Phase 4
4 A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
5 Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects Recruiting NCT02682901 Phase 4 Cycloset;Placebo
6 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
7 An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes Completed NCT00116207 Phase 3 ORAL ANTIOXIDANT
8 Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT) Completed NCT00594152 Phase 3 CIIIT
9 Fluid Retention in Rosiglitazone Treated Subjects With Autonomic Neuropathy. Completed NCT00422955 Phase 3 rosiglitazone
10 Effect of Autonomic Neuropathy on the Efficacy of a DPP-IV Inhibitor (Galvus) Therapy Completed NCT01452113 Phase 2 Vildagliptin
11 Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy Completed NCT00760955 Phase 2 TAK-583;TAK-583;TAK-583;Placebo
12 A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
13 The Efficacy Of Intravenous Immunoglobulin Therapy In Treatment Induced Neuropathy Of Diabetes Recruiting NCT02915263 Phase 2 IGIV-C;0.9% Sodium Chloride
14 A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes Unknown status NCT01822431
15 The Relationship Between Vascular Adhesion Protein-1 and Diabetic Cardiovascular Autonomic Neuropathy Unknown status NCT01706289
16 Sleep Apnea in Type 1 Diabetes Unknown status NCT01935765 Early Phase 1
17 Effect of DPP-IV Inhibitor on Glycemic Control and Autonomic Neuropathy in Adult Patients With Diabetes Mellitus Unknown status NCT01545024 Sitagliptin, 50 mg once per day per os
18 The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction Completed NCT00919347
19 Coronary Blood Flow Regulation During General Anesthesia Completed NCT00866801
20 NIR- and Multifrequent Impedance Spectroscopy on the Skin in Type 1 Diabetes Completed NCT01707979
21 Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients Completed NCT00953914 Pyridostigmine;Placebo
22 Evaluation of Exenatide in Patients With Diabetic Neuropathy Completed NCT00855439 Exenatide;Glargine
23 Diabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study Completed NCT01160887
24 Study of 24 Hour Blood Pressure and the Association to Complications to Type 1 Diabetes Completed NCT01171248
25 Heart Rate Variability and Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients Completed NCT02996539
26 Tolerance to Hemodialysis in Insulin-Requiring Diabetic Patients: BD vs AFB With Blood Volume Biofeedback Completed NCT01098149
27 The Effect of Spinal Anesthesia on Heart Rate Variability in Diabetic Patients Completed NCT02137057
28 Peripheral Endothelial Function and Coronary Status in Asymptomatic Diabetic Patients Completed NCT00685984
29 Prevalence of Morbidity in Newly Diagnosed type2 Diabetes in Adults Completed NCT02002091
30 Gastrointestinal Motility Among Diabetes Patients Recruiting NCT02573519 3D-Transit during treatment with Pyridostigmine
31 Bayesian Estimation of Diagnostic Performance of Diabetic Cardiovascular Autonomic Neuropathy Without a Gold Standard Recruiting NCT02461381
32 Risk Analysis for Diabetic Cardiovascular Autonomic Neuropathy Recruiting NCT02461472
33 Enhance Balance and Mobility in People With Type 2 Diabetic Peripheral Neuropathy Recruiting NCT02541838
34 Improving Autonomic Function and Balance in Diabetic Neuropathy Recruiting NCT01864460
35 QUANtification of Cardiovascular Autonomic Neuropathy (CAN) and the Effects of Anaesthesia on Haemodynamics and Cerebral Perfusion Recruiting NCT03071432
36 Investigation of the Rewarming og the Fingers After Cooling and the Autonomic Nervous System in Raynaud's Phenomenon Recruiting NCT03094910
37 Passive Training as a Treatment for Diabetic Foot Ulcers Recruiting NCT02785198
38 Detection no Invasive of a Silent Myocardial Ischemia Recruiting NCT02885428
39 Safety and Efficacy of Three Local Block Techniques for Diabetic Foot Surgery Not yet recruiting NCT03155568 Bupivacaine

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: diabetic neuropathies

Genetic Tests for Diabetic Autonomic Neuropathy

Anatomical Context for Diabetic Autonomic Neuropathy

MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

39
Heart, Testes, Skin, Kidney, Endothelial, Brain, Pancreatic Islet

Publications for Diabetic Autonomic Neuropathy

Articles related to Diabetic Autonomic Neuropathy:

(show top 50) (show all 291)
id Title Authors Year
1
Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension. ( 28623420 )
2017
2
Treatment of Diabetic Autonomic Neuropathy in Older Adults with Diabetes Mellitus. ( 28107120 )
2016
3
Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy. ( 26706915 )
2015
4
Inspiratory muscle training in patients with diabetic autonomic neuropathy: a randomized clinical trial. ( 25982993 )
2015
5
Role of Microcirculatory Disturbances and Diabetic Autonomic Neuropathy in Takotsubo Cardiomyopathy. ( 26468716 )
2015
6
Diabetic autonomic neuropathy. ( 25410215 )
2014
7
CORNEAL confocal microscopy for the diagnosis of diabetic autonomic neuropathy. ( 25556884 )
2014
8
Disproportionate pupillary involvement in diabetic autonomic neuropathy. ( 25377131 )
2014
9
Association of diabetic autonomic neuropathy with red blood cell aldose reductase activity. ( 24485209 )
2014
10
Diabetic autonomic neuropathy affects symptom generation and brain-gut axis. ( 24026548 )
2013
11
Diabetic autonomic neuropathy. ( 24095132 )
2013
12
Diabetic autonomic neuropathy. ( 23393679 )
2012
13
Mortality after acute myocardial infarction: significance of cardiovascular diabetic autonomic neuropathy (CDAN). ( 23097964 )
2012
14
Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. ( 22306250 )
2012
15
The relationship between diabetic autonomic neuropathy and diabetic risk factors in a Taiwanese population. ( 21986117 )
2011
16
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. ( 21247746 )
2011
17
The effect of diabetic autonomic neuropathy on P-wave duration, dispersion and atrial fibrillation. ( 22291825 )
2011
18
Vasopressin release induced by hypothension is blunted in patients with diabetic autonomic neuropathy. ( 20370555 )
2011
19
Severe orthostatic hypotension in a diabetic patient may not be due to diabetic autonomic neuropathy. ( 21902089 )
2011
20
Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy? ( 20837965 )
2010
21
Different effects of diabetic autonomic neuropathy on regional transcutaneous oxygen tension in patients with peripheral arterial disease. ( 21466127 )
2010
22
Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy. ( 20624170 )
2010
23
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. ( 20156724 )
2009
24
New insights in diabetic autonomic neuropathy in children and adolescents. ( 19734243 )
2009
25
A pharmacologic pupillary test in the diagnosis of diabetic autonomic neuropathy. ( 20046691 )
2009
26
Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. ( 17967455 )
2008
27
The impact of diabetic autonomic neuropathy on the incretin effect. ( 18376350 )
2008
28
Dynamic cerebral autoregulation assessment using chaotic analysis in diabetic autonomic neuropathy. ( 17874153 )
2008
29
Ergotamine use in severe diabetic autonomic neuropathy. ( 17227338 )
2007
30
Gut sensations in diabetic autonomic neuropathy. ( 17521809 )
2007
31
Severe orthostatic hypotension with diabetic autonomic neuropathy successfully treated with a beta(1)-blocker: a case report. ( 16810280 )
2006
32
Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. ( 16389160 )
2006
33
Ergotamine use in severe diabetic autonomic neuropathy. ( 16681568 )
2006
34
Images in clinical medicine. Gastric dilatation secondary to diabetic autonomic neuropathy. ( 16371635 )
2005
35
Acute dysautonomia: a rare manifestation of diabetic autonomic neuropathy masquerading as pheochromocytoma. ( 16279988 )
2005
36
Severe and disabling diabetic autonomic neuropathy: a case report. ( 15120708 )
2004
37
Diabetic autonomic neuropathy: evidence for apoptosis in situ in the rat. ( 15198656 )
2004
38
Pupillography refines the diagnosis of diabetic autonomic neuropathy. ( 15240199 )
2004
39
Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. ( 12663561 )
2003
40
Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathy. ( 12819007 )
2003
41
Comparative neuropathology and diabetic autonomic neuropathy. ( 14578168 )
2003
42
Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. ( 14578206 )
2003
43
Diabetic autonomic neuropathy. ( 15088257 )
2003
44
Diabetic autonomic neuropathy. ( 12716821 )
2003
45
Diabetic autonomic neuropathy: importance of its early detection for improving morbidity and mortality. ( 12879940 )
2003
46
Diagnosis and management of diabetic autonomic neuropathy. ( 14606343 )
2003
47
The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. ( 12502507 )
2003
48
Diagnosis of diabetic autonomic neuropathy: a multivariate approach. ( 12864779 )
2003
49
Diabetic autonomic neuropathy is associated with an increased incidence of strokes. ( 14614967 )
2003
50
Does diabetic autonomic neuropathy influence the clinical manifestations of reflux esophagitis? ( 14604253 )
2003

Variations for Diabetic Autonomic Neuropathy

Expression for Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for Diabetic Autonomic Neuropathy

Pathways related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 AOC1 DBH
2
Show member pathways
10.98 NGF NTF3
3
Show member pathways
10.74 NGF NTF3
4 10.3 EPO INS

GO Terms for Diabetic Autonomic Neuropathy

Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 AKR1B1 AOC1 DBH EPO INS
2 extracellular region GO:0005576 9.1 AOC1 DBH EPO INS NGF NTF3

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.54 INS NGF NTF3
2 neuron projection morphogenesis GO:0048812 9.4 NGF NTF3
3 positive regulation of DNA replication GO:0045740 9.32 EPO INS
4 acute-phase response GO:0006953 9.26 EPO INS
5 activation of protein kinase B activity GO:0032148 9.16 INS NTF3
6 regulation of neuron differentiation GO:0045664 8.96 NGF NTF3
7 positive regulation of Ras protein signal transduction GO:0046579 8.62 EPO NGF

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 AOC1 DBH

Sources for Diabetic Autonomic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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