MCID: DBT002
MIFTS: 44

Diabetic Autonomic Neuropathy malady

Neuronal category

Summaries for Diabetic Autonomic Neuropathy

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33MalaCards
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MalaCards: Diabetic Autonomic Neuropathy is related to autonomic neuropathy and hypoglycemia. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are HIF-1 signaling pathway and PI3K-Akt signaling pathway. The compounds norepinephrine and em 523 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Diabetic Autonomic Neuropathy

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

diabetic autonomic neuropathy 8 45 61


External Ids:

Disease Ontology8 DOID:11503
NCIt40 C27068
SNOMED-CT57 50620007
MeSH35 D003929

Related Diseases for Diabetic Autonomic Neuropathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1autonomic neuropathy32.0GCG, GAST, AKR1B1, MLN, NTF3, NGF
2hypoglycemia30.8GCG, GAST, AKR1B1, MLN, IGF1, INS
3neuroaxonal dystrophy30.2NTF3, NGF
4acute myocardial infarction30.2GCG
5pheochromocytoma30.2NGF, NTF3, MLN
6vascular disease30.2AKR1B1, NGF, INS
7postural hypotension10.7
8autonomic dysfunction10.5
9autonomic peripheral neuropathy10.4
10iritis10.4
11axonal neuropathy10.1
12reflex sympathetic dystrophy10.1
13gastric dilatation10.1
14motor peripheral neuropathy10.1
15dysautonomia10.1
16hypoxia10.1
17somatostatin analog10.1
18polyneuropathy10.0AKR1B1
19liver cirrhosis10.0MLN
20irritable bowel syndrome10.0MLN
21constipation10.0MLN
22parkinson's disease10.0NGF
23motor neuron disease10.0NTF3
24hydrocephalus10.0NTF3
25dermatitis10.0NTF3
26neuroblastoma10.0NGF
27atopic dermatitis10.0NGF
28multiple endocrine neoplasia10.0GAST
29gastroduodenitis10.0GAST
30duodenitis10.0GAST
31eye disease10.0NGF
32pancreatic islet cell tumors10.0GAST
33esophagitis10.0GAST
34pyloric stenosis10.0GAST
35malignant glioma10.0NTF3
36eating disorder10.0INS
37peptic ulcer10.0GAST
38gastric ulcer10.0GAST
39paraganglioma10.0GAST
40cushing's syndrome10.0INS
41stroke, ischemic10.0INS
42pallister-hall syndrome10.0HCN3
43somatostatinoma10.0GAST
44donohue syndrome10.0INS
45ileus10.0MLN, MLNR
46fetal macrosomia10.0INS
47polycythemia10.0EPO
48zollinger-ellison syndrome10.0GAST
49essential hypertension10.0INS
50neuroendocrine tumor10.0GCG

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to diabetic autonomic neuropathy

Clinical Features for Diabetic Autonomic Neuropathy

Drugs & Therapeutics for Diabetic Autonomic Neuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Autonomic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Autonomic Neuropathy

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Search CenterWatch for Diabetic Autonomic Neuropathy

Genetic Tests for Diabetic Autonomic Neuropathy

Anatomical Context for Diabetic Autonomic Neuropathy

Sources:
33MalaCards
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MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

33
Brain, Spinal cord, Heart, Colon, Salivary gland, Adrenal gland, Skin, T cells, Pancreatic islet

Animal Models for Diabetic Autonomic Neuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3IGF1, HCN3, NGF, EPO, INS, NTF3
2MP:00053767.0INS, GCG, GAST, AKR1B1, NTF3, IGF1
3MP:00107686.8GCG, GAST, AKR1B1, NTF3, IGF1, NGF

Publications for Diabetic Autonomic Neuropathy

Sources:
51PubMed
See all sources

Articles related to Diabetic Autonomic Neuropathy:

(show top 50)    (show all 421)
idTitleAuthorsYear
1
Retraction. A novel quantitative method for diabetic cardiac autonomic neuropathy assessment in type I diabetic mice. (23504179)
2013
2
Sudoscan, a noninvasive tool for detecting diabetic small fiber neuropathy and autonomic dysfunction. (23889506)
2013
3
Vasopressin release induced by hypothension is blunted in patients with diabetic autonomic neuropathy. (20370555)
2011
4
Is cardiac autonomic neuropathy the basis of nonischemic diabetic cardiomyopathy? (21163449)
2010
5
Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. (20437589)
2010
6
Cardiovascular autonomic neuropathy, autonomic symptoms and diabetic complications in 674 type 2 diabetes. (18824270)
2008
7
Urinary flow disturbance as an early sign of autonomic neuropathy in diabetic children and adolescents. (17078072)
2007
8
Usefulness of ambulatory blood pressure monitoring in predicting the presence of autonomic neuropathy in type I diabetic patients. (17301823)
2007
9
QT dispersion: comparison between diabetic and non-diabetic individuals and correlation with cardiac autonomic neuropathy. (17134060)
2006
10
Skin blood flow in the upper and lower extremities of diabetic patients with and without autonomic neuropathy. (15528936)
2004
11
Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. (14578206)
2003
12
Increasing homocysteine levels and diabetic autonomic neuropathy. (11476288)
2001
13
Diabetic autonomic neuropathy: the clinical interpretation of improved technology. (11469710)
2001
14
Asymptomatic coronary artery disease is associated with cardiac autonomic neuropathy and diabetic nephropathy in type 2 diabetic patients. (10526747)
1999
15
Effect of glycemic control on heart rate variability in type I diabetic patients with cardiac autonomic neuropathy. (10498140)
1999
16
Nocturnal oxygen desaturation in diabetic patients with severe autonomic neuropathy. (7587925)
1995
17
Diabetic autonomic neuropathy. (8536542)
1995
18
Catecholamines and diabetic autonomic neuropathy. (7600741)
1995
19
Prospective study of autonomic nerve function in type 1 and type 2 diabetic patients: 24 hour heart rate variation and plasma motilin levels disturbed in parasympathetic neuropathy. (8582123)
1995
20
Plasma endothelin in diabetic autonomic neuropathy. (8137692)
1994
21
Epinephrine secretion, hypoglycemia unawareness, and diabetic autonomic neuropathy. (8311375)
1994
22
Progression of diabetic autonomic neuropathy. (8334849)
1993
23
Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin. (1425065)
1992
24
Diabetic autonomic neuropathy. (1862685)
1991
25
Heartbeat and arrhythmia perception in diabetic autonomic neuropathy. (1715091)
1991
26
Sural nerve morphometry in diabetic autonomic and painful sensory neuropathy. A clinicopathological study. (2043955)
1991
27
Unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation: no causal relation with diabetic autonomic neuropathy. (2224265)
1990
28
Diabetic autonomic neuropathy: the prevalence of impaired heart rate variability in a geographically defined population. (2522369)
1989
29
Skin microvascular reflexes in patients with diabetic autonomic neuropathy. (3167651)
1988
30
Pancreatic polypeptide (PP) response to food in type I diabetics with and without diabetic autonomic neuropathy. (3229733)
1988
31
Loss of spontaneous variability of fingertip anastomotic blood flow in diabetic autonomic neuropathy. (3581682)
1987
32
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
33
Diabetic autonomic neuropathy. (3773726)
1986
34
Diabetic autonomic neuropathy in BB rat. Ultrastructural and morphometric changes in parasympathetic nerves. (3721060)
1986
35
Variable relationship between peripheral somatic and autonomic neuropathy in patients with different syndromes of diabetic polyneuropathy. (3002887)
1986
36
Cardiac dysrhythmia in diabetic autonomic neuropathy. (4093409)
1985
37
Glucose counterregulation in diabetic autonomic neuropathy. (2870835)
1985
38
Diabetic autonomic neuropathy and iritis: an association suggesting an immunological cause. (6432089)
1984
39
The prevalence of diabetic autonomic neuropathy indicated by abnormal R-R interval variation. (6096985)
1983
40
'Tear gas' for the diagnosis of diabetic autonomic neuropathy? (7128975)
1982
41
Combination H1 and H2 receptor antagonist therapy in diabetic autonomic neuropathy. (6123154)
1982
42
A sensitive orthostatic test on tilt table, useful in the detection of diabetic autonomic neuropathy. (6953750)
1981
43
Gastric emptying in diabetic autonomic neuropathy. (6769774)
1980
44
Aspects of diabetic autonomic neuropathy. Introduction and workshop summary. (7356217)
1980
45
Impaired cardiovascular responses to graded exercise in diabetic autonomic neuropathy. (437371)
1979
46
Editorial: Structure and function in diabetic autonomic neuropathy. (1260268)
1976
47
Provocation of postural hypotension by insulin in diabetic autonomic neuropathy. (942932)
1976
48
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975
49
Defective innervation of heart in diabetic autonomic neuropathy. (1131653)
1975
50
Facial sweating after food: a new sign of diabetic autonomic neuropathy. (4144374)
1973

Genetic Variations for Diabetic Autonomic Neuropathy

Expression for genes affiliated with Diabetic Autonomic Neuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for genes affiliated with Diabetic Autonomic Neuropathy

Sources:
30KEGG, 54Reactome
See all sources

Pathways related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4INS, EPO, IGF1
29.2INS, IGF1, NGF, EPO
3
Hide members
8.2GCG, GAST, MLNR, MLN
4
Hide members
7.2GAST, MLNR, MLN, IGF1, NGF, INS

Compounds for genes affiliated with Diabetic Autonomic Neuropathy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.0GAST, NTF3
2em 523459.7MLN, MLNR
3aminoguanidine45 29 1111.7AKR1B1, AOC1, EPO
4trimebutine459.5MLN, GAST
5ly294002459.5NGF, NTF3, GCG
6gnrh459.5GAST, GCG
7levodopa45 1110.4IGF1, AOC1, NGF, AKR1B1
8ondansetron45 50 11 2412.4GAST, MLN, EPO
9voglibose45 1110.4INS, GCG
10acipimox45 2910.3IGF1, GCG, INS
11vitamin b12459.3AKR1B1, GAST, EPO, IGF1
12streptozotocin459.2GCG, AKR1B1, NTF3, INS
13cisapride45 29 1111.1GCG, MLNR, MLN
14hydrocortisone45 2 60 1112.1IGF1, GAST, EPO, INS
15i-app459.1GCG, INS, GAST
16pirenzepine45 29 1111.0GCG, IGF1, GAST
17bethanechol45 29 1111.0GAST, GCG, MLN
18glycerol45 11 2410.9INS, GCG, AKR1B1, NGF
19oxyntomodulin45 609.9MLN, GAST, GCG
20calcitriol45 60 11 2411.9IGF1, NGF, EPO, GAST
21thyroxine45 249.8IGF1, NGF, INS, MLN, GAST
22thymidine45 249.8IGF1, EPO, GAST, NTF3, NGF
23starch458.8INS, GCG, IGF1, GAST
24carbachol45 29 1110.7NGF, NTF3, GAST, GCG
25genistein45 29 60 2 11 2413.7AKR1B1, GCG, NGF, IGF1, NTF3
26c-peptide458.7INS, IGF1, GCG, GAST
27atropine45 29 1110.7MLN, NGF, GCG, GAST
28acth458.7INS, IGF1, GAST, MLN
29wortmannin458.7GCG, NTF3, INS, NGF, IGF1
30rapamycin458.7INS, EPO, IGF1, NTF3, GCG
31testosterone45 60 11 2411.6GAST, AKR1B1, INS, IGF1, EPO, NGF
32nifedipine45 50 29 1111.6NGF, GCG, GAST, MLN
33nicotinamide45 119.5AKR1B1, EPO, INS, GAST, GCG
34epinephrine45 11 2410.5GAST, AKR1B1, GCG, NGF, INS
35alanine458.5INS, GAST, NGF, MLN, MLNR, AKR1B1
36lactate458.4AOC1, AKR1B1, GCG, INS, EPO
37acetylcholine45 50 29 11 2412.3GCG, GAST, MLN, NGF, NTF3
385-hydroxytryptamine458.3GAST, GCG, AOC1, MLN
39adenylate458.1NGF, MLN, AKR1B1, GAST, NTF3, GCG
40glutamine458.0IGF1, NGF, AOC1, AKR1B1, GAST, GCG
41octreotide45 60 29 1111.0GAST, GCG, MLN, IGF1, EPO, INS
42vegf457.9EPO, NGF, IGF1, GCG, AKR1B1, GAST
43histamine45 29 249.9NTF3, GAST, GCG, NGF, AOC1, MLN
44glutamate457.8GCG, AOC1, NTF3, NGF, GAST, INS
45dopamine45 29 11 2410.6GCG, GAST, MLNR, NTF3, IGF1, NGF
46estrogen457.6AKR1B1, GAST, GCG, INS, IGF1, NTF3
47arginine457.5AOC1, IGF1, NGF, INS, MLN, AKR1B1
48heparin45 29 11 2410.5GCG, NTF3, AOC1, MLN, GAST
49creatinine457.4GAST, EPO, INS, AKR1B1, NGF, IGF1
50glucose457.2GCG, GAST, AKR1B1, INS, MLN, AOC1

GO Terms for genes affiliated with Diabetic Autonomic Neuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.3INS, GCG
2extracellular spaceGO:0056157.4INS, GCG, AKR1B1, AOC1, IGF1, NGF
3extracellular regionGO:0055766.7INS, GCG, GAST, MLN, NTF3, IGF1

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein autophosphorylationGO:03195410.1INS, NGF
2positive regulation of glycolysisGO:04582110.0INS, IGF1
3response to electrical stimulusGO:05160210.0EPO, NGF
4positive regulation of glycogen biosynthetic processGO:04572510.0IGF1, INS
5positive regulation of Ras protein signal transductionGO:0465799.9EPO, IGF1
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IGF1, EPO
7positive regulation of mitosisGO:0458409.8IGF1, INS
8activation of protein kinase B activityGO:0321489.7INS, NTF3
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7INS, IGF1, NTF3
10positive regulation of DNA replicationGO:0457409.7INS, IGF1, EPO
11positive regulation of glucose importGO:0463269.5IGF1, INS
12positive regulation of cell proliferationGO:0082849.3NTF3, IGF1, EPO, INS
13G-protein coupled receptor signaling pathwayGO:0071868.1GAST, GCG, MLNR, INS, MLN
14signal transductionGO:0071658.0IGF1, NTF3, GAST, GCG, EPO

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor bindingGO:0051589.8IGF1, INS
2insulin-like growth factor receptor bindingGO:0051599.7IGF1, INS
3sodium channel activityGO:0052729.4HCN3, AOC1
4growth factor activityGO:0080839.2NGF, IGF1, NTF3
5hormone activityGO:0051797.6MLN, GCG, GAST, IGF1, EPO, INS

Products for genes affiliated with Diabetic Autonomic Neuropathy

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Sources for Diabetic Autonomic Neuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet