MCID: DBT002
MIFTS: 43

Diabetic Autonomic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Autonomic Neuropathy

MalaCards integrated aliases for Diabetic Autonomic Neuropathy:

Name: Diabetic Autonomic Neuropathy 12 51 14 69
Diabetic Neuropathies 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11503
MeSH 41 D003929
NCIt 46 C27068
SNOMED-CT 64 50620007
UMLS 69 C0271686

Summaries for Diabetic Autonomic Neuropathy

MalaCards based summary : Diabetic Autonomic Neuropathy, also known as diabetic neuropathies, is related to diabetic neuropathy and microvascular complications of diabetes 5, and has symptoms including sciatica and neuralgia. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are PI3K-Akt signaling pathway and p75(NTR)-mediated signaling. The drugs Quinapril and Bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and pancreatic islet, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Diabetic Autonomic Neuropathy

Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 diabetic neuropathy 32.7 AKR1B1 EPO INS NGF NTF3
2 microvascular complications of diabetes 5 31.8 AKR1B1 INS
3 autonomic neuropathy 30.9 AKR1B1 EPO INS NGF
4 postural hypotension 30.3 DBH INS
5 microvascular complications of diabetes 1 11.5
6 neuropathy 11.0
7 microvascular complications of diabetes 3 10.3 AKR1B1 INS
8 sheehan syndrome 10.3 EPO INS
9 hypoglycemic coma 10.3 INS NTF3
10 fetal erythroblastosis 10.3 EPO INS
11 retinal vascular disease 10.2 AKR1B1 INS
12 pancreatitis 10.2
13 hypoglycemia 10.2
14 ocular dominance 10.0 NGF NTF3
15 uremia 10.0 EPO INS
16 cardiac conduction defect 10.0
17 iritis 10.0
18 ring chromosome y syndrome 10.0
19 sensory peripheral neuropathy 10.0 NGF NTF3
20 peripheral nervous system disease 9.9 INS NGF
21 renal hypertension 9.9 DBH EPO
22 aging 9.9
23 myocardial infarction 9.9
24 episodic pain syndrome, familial, 1 9.9
25 diabetes mellitus 9.9
26 streptococcal group a invasive disease 9.9
27 early-onset schizophrenia 9.9 DBH INS
28 pure autonomic failure 9.9 DBH EPO
29 keratoconjunctivitis 9.9 AOC1 NGF
30 diabetic polyneuropathy 9.8 AKR1B1 NGF NTF3
31 urinary system disease 9.8 EPO INS
32 neuropathy, hereditary sensory and autonomic, type iii 9.7 DBH NGF
33 arteries, anomalies of 9.7
34 pheochromocytoma 9.7
35 neuroblastoma 9.7
36 insulin-like growth factor i 9.7
37 body mass index quantitative trait locus 11 9.7
38 body mass index quantitative trait locus 9 9.7
39 body mass index quantitative trait locus 8 9.7
40 reflex sympathetic dystrophy 9.7
41 resting heart rate, variation in 9.7
42 body mass index quantitative trait locus 4 9.7
43 body mass index quantitative trait locus 10 9.7
44 body mass index quantitative trait locus 7 9.7
45 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7
46 body mass index quantitative trait locus 12 9.7
47 body mass index quantitative trait locus 14 9.7
48 body mass index quantitative trait locus 18 9.7
49 acute myocardial infarction 9.7
50 peripheral artery disease 9.7

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to Diabetic Autonomic Neuropathy

Symptoms & Phenotypes for Diabetic Autonomic Neuropathy

UMLS symptoms related to Diabetic Autonomic Neuropathy:


sciatica, neuralgia

MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 AOC1 DBH EPO INS NGF NTF3
2 homeostasis/metabolism MP:0005376 9.5 AKR1B1 AOC1 DBH EPO INS NGF
3 vision/eye MP:0005391 9.1 DBH INS NGF NTF3 AKR1B1 AOC1

Drugs & Therapeutics for Diabetic Autonomic Neuropathy

Drugs for Diabetic Autonomic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
2
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Donepezil Approved Phase 4 120014-06-4 3152
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
7
Norepinephrine Approved Phase 4 51-41-2 439260
8 Angiotensin-Converting Enzyme Inhibitors Phase 4
9 Antihypertensive Agents Phase 4
10 HIV Protease Inhibitors Phase 4,Phase 2
11
protease inhibitors Phase 4,Phase 2
12 Hormone Antagonists Phase 4,Phase 2
13 Hormones Phase 4,Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
15 Analgesics Phase 4,Phase 2
16 Anti-Anxiety Agents Phase 4,Phase 2
17 Anticonvulsants Phase 4,Phase 2
18 calcium channel blockers Phase 4,Phase 2
19 Calcium, Dietary Phase 4,Phase 2
20 Central Nervous System Depressants Phase 4,Phase 2
21 Peripheral Nervous System Agents Phase 4,Phase 2
22 Psychotropic Drugs Phase 4,Phase 2
23 Tranquilizing Agents Phase 4,Phase 2
24 Antiparkinson Agents Phase 4
25 Dopamine Agents Phase 4
26 Dopamine agonists Phase 4
27 Neurotransmitter Agents Phase 4
28 Cholinergic Agents Phase 4
29 Cholinesterase Inhibitors Phase 4
30 Nootropic Agents Phase 4
31 Antidepressive Agents Phase 4
32 Antimanic Agents Phase 4
33 Duloxetine Hydrochloride Phase 4
34 Excitatory Amino Acid Antagonists Phase 4
35 Excitatory Amino Acids Phase 4
36 GABA Agents Phase 4
37 Neurotransmitter Uptake Inhibitors Phase 4
38
Serotonin Phase 4 50-67-9 5202
39 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
40
Allopurinol Approved Phase 3 315-30-0 2094
41
Zinc Approved, Investigational Phase 3 7440-66-6 32051 23994
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
43
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
44
Nicotinamide Approved, Investigational, Nutraceutical Phase 3 98-92-0 936
45 Antimetabolites Phase 3
46 Antioxidants Phase 3
47 Antirheumatic Agents Phase 3
48 Hypolipidemic Agents Phase 3
49 Lipid Regulating Agents Phase 3
50 Micronutrients Phase 3

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
2 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
3 Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects Recruiting NCT02682901 Phase 4 Cycloset;Placebo
4 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
5 An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes Completed NCT00116207 Phase 3 ORAL ANTIOXIDANT
6 Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT) Completed NCT00594152 Phase 3 CIIIT
7 Effect of Autonomic Neuropathy on the Efficacy of a DPP-IV Inhibitor (Galvus) Therapy Completed NCT01452113 Phase 2 Vildagliptin
8 Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy Completed NCT00760955 Phase 2 TAK-583;TAK-583;TAK-583;Placebo
9 A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
10 A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes Unknown status NCT01822431
11 The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction Completed NCT00919347
12 Coronary Blood Flow Regulation During General Anesthesia Completed NCT00866801
13 Gastrointestinal Motility Among Diabetes Patients Recruiting NCT02573519 3D-Transit during treatment with Pyridostigmine

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: diabetic neuropathies

Genetic Tests for Diabetic Autonomic Neuropathy

Anatomical Context for Diabetic Autonomic Neuropathy

MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

38
Heart, Testes, Pancreatic Islet, Skin, Eye, Brain

Publications for Diabetic Autonomic Neuropathy

Articles related to Diabetic Autonomic Neuropathy:

(show top 50) (show all 291)
# Title Authors Year
1
Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension. ( 28623420 )
2017
2
Treatment of Diabetic Autonomic Neuropathy in Older Adults with Diabetes Mellitus. ( 28107120 )
2016
3
Inspiratory muscle training in patients with diabetic autonomic neuropathy: a randomized clinical trial. ( 25982993 )
2015
4
Role of Microcirculatory Disturbances and Diabetic Autonomic Neuropathy in Takotsubo Cardiomyopathy. ( 26468716 )
2015
5
Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy. ( 26706915 )
2015
6
CORNEAL confocal microscopy for the diagnosis of diabetic autonomic neuropathy. ( 25556884 )
2014
7
Association of diabetic autonomic neuropathy with red blood cell aldose reductase activity. ( 24485209 )
2014
8
Diabetic autonomic neuropathy. ( 25410215 )
2014
9
Disproportionate pupillary involvement in diabetic autonomic neuropathy. ( 25377131 )
2014
10
Diabetic autonomic neuropathy. ( 24095132 )
2013
11
Diabetic autonomic neuropathy affects symptom generation and brain-gut axis. ( 24026548 )
2013
12
Diabetic autonomic neuropathy. ( 23393679 )
2012
13
Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. ( 22306250 )
2012
14
Mortality after acute myocardial infarction: significance of cardiovascular diabetic autonomic neuropathy (CDAN). ( 23097964 )
2012
15
Severe orthostatic hypotension in a diabetic patient may not be due to diabetic autonomic neuropathy. ( 21902089 )
2011
16
The relationship between diabetic autonomic neuropathy and diabetic risk factors in a Taiwanese population. ( 21986117 )
2011
17
The effect of diabetic autonomic neuropathy on P-wave duration, dispersion and atrial fibrillation. ( 22291825 )
2011
18
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. ( 21247746 )
2011
19
Vasopressin release induced by hypothension is blunted in patients with diabetic autonomic neuropathy. ( 20370555 )
2011
20
Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy? ( 20837965 )
2010
21
Different effects of diabetic autonomic neuropathy on regional transcutaneous oxygen tension in patients with peripheral arterial disease. ( 21466127 )
2010
22
Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy. ( 20624170 )
2010
23
A pharmacologic pupillary test in the diagnosis of diabetic autonomic neuropathy. ( 20046691 )
2009
24
New insights in diabetic autonomic neuropathy in children and adolescents. ( 19734243 )
2009
25
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. ( 20156724 )
2009
26
Dynamic cerebral autoregulation assessment using chaotic analysis in diabetic autonomic neuropathy. ( 17874153 )
2008
27
The impact of diabetic autonomic neuropathy on the incretin effect. ( 18376350 )
2008
28
Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. ( 17967455 )
2008
29
Ergotamine use in severe diabetic autonomic neuropathy. ( 17227338 )
2007
30
Gut sensations in diabetic autonomic neuropathy. ( 17521809 )
2007
31
Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. ( 16389160 )
2006
32
Ergotamine use in severe diabetic autonomic neuropathy. ( 16681568 )
2006
33
Severe orthostatic hypotension with diabetic autonomic neuropathy successfully treated with a beta(1)-blocker: a case report. ( 16810280 )
2006
34
Images in clinical medicine. Gastric dilatation secondary to diabetic autonomic neuropathy. ( 16371635 )
2005
35
Acute dysautonomia: a rare manifestation of diabetic autonomic neuropathy masquerading as pheochromocytoma. ( 16279988 )
2005
36
Diabetic autonomic neuropathy: evidence for apoptosis in situ in the rat. ( 15198656 )
2004
37
Severe and disabling diabetic autonomic neuropathy: a case report. ( 15120708 )
2004
38
Pupillography refines the diagnosis of diabetic autonomic neuropathy. ( 15240199 )
2004
39
Does diabetic autonomic neuropathy influence the clinical manifestations of reflux esophagitis? ( 14604253 )
2003
40
Diabetic autonomic neuropathy. ( 15088257 )
2003
41
The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. ( 12502507 )
2003
42
Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathy. ( 12819007 )
2003
43
Diabetic autonomic neuropathy: importance of its early detection for improving morbidity and mortality. ( 12879940 )
2003
44
Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy. ( 12663561 )
2003
45
Diabetic autonomic neuropathy is associated with an increased incidence of strokes. ( 14614967 )
2003
46
Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. ( 14578206 )
2003
47
Diagnosis of diabetic autonomic neuropathy: a multivariate approach. ( 12864779 )
2003
48
Diagnosis and management of diabetic autonomic neuropathy. ( 14606343 )
2003
49
Diabetic autonomic neuropathy. ( 12716821 )
2003
50
Comparative neuropathology and diabetic autonomic neuropathy. ( 14578168 )
2003

Variations for Diabetic Autonomic Neuropathy

Expression for Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for Diabetic Autonomic Neuropathy

Pathways related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 EPO INS NGF NTF3
2
Show member pathways
11.08 NGF NTF3
3
Show member pathways
10.94 NGF NTF3
4 10.64 EPO INS

GO Terms for Diabetic Autonomic Neuropathy

Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 AKR1B1 AOC1 DBH EPO INS
2 extracellular region GO:0005576 9.1 AOC1 DBH EPO INS NGF NTF3

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.58 INS NGF NTF3
2 neuron projection morphogenesis GO:0048812 9.43 NGF NTF3
3 positive regulation of DNA replication GO:0045740 9.37 EPO INS
4 acute-phase response GO:0006953 9.32 EPO INS
5 activation of protein kinase B activity GO:0032148 9.26 INS NTF3
6 regulation of neuron differentiation GO:0045664 9.16 NGF NTF3
7 positive regulation of Ras protein signal transduction GO:0046579 8.96 EPO NGF
8 regulation of receptor activity GO:0010469 8.92 EPO INS NGF NTF3

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 AOC1 DBH

Sources for Diabetic Autonomic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....