MCID: DBT002
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Diabetic Autonomic Neuropathy malady

Neuronal diseases category

Summaries for Diabetic Autonomic Neuropathy

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34MalaCards
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MalaCards: Diabetic Autonomic Neuropathy is related to neuropathy and autonomic neuropathy. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and Id Signaling Pathway. The compounds acipimox and aminoguanidine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and eye, and related mouse phenotypes are normal and growth/size/body.

Aliases & Classifications for Diabetic Autonomic Neuropathy

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9Disease Ontology, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

diabetic autonomic neuropathy 9 46 63


External Ids:

Disease Ontology9 DOID:11503
NCIt41 C27068
SNOMED-CT59 50620007
MeSH36 D003929

Related Diseases for Diabetic Autonomic Neuropathy

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18GeneCards, 19GeneDecks
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Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.0NTF3, AKR1B1, NGF, INS
2autonomic neuropathy31.7EPO, GAST, NTF3, AKR1B1, NGF, INS
3hypoglycemia30.6AKR1B1, GAST, IGF1, GCG, INS, MLN
4pheochromocytoma30.3NGF, MLN, NTF3
5vascular disease30.3AKR1B1, INS, NGF
6type 1 diabetes mellitus30.1MLNR, IGF1, AKR1B1, GCG, INS
7obesity30.1GCG, IGF1, INS, MLN, AKR1B1
8diabetes mellitus30.0MLN, IGF1, NGF, INS, AKR1B1, GCG
9postural hypotension10.7
10pancreatitis10.6
11iritis10.4
12hypertension10.3
13myocardial infarction10.3
14blindness10.3
15reflex sympathetic dystrophy10.2
16peripheral artery disease10.2
17gastric dilatation10.2
18cerebritis10.2
19acute myocardial infarction10.2
20artery disease10.2
21esophagitis10.2
22neuroblastoma10.2
23peripheral neuropathy10.2
24autonomic dysfunction10.2
25dysautonomia10.2
26hypoxia10.2
27duodenitis10.1GAST
28somatostatinoma10.1GAST
29polyneuropathy10.1AKR1B1
30zollinger-ellison syndrome10.1GAST
31laron syndrome10.1IGF1
32rhinitis10.1AOC1
33donohue syndrome10.1INS
34fetal macrosomia10.1INS
35corneal disease10.1NGF, AKR1B1
36gallbladder disease10.1MLNR, MLN
37ileus10.1MLN, MLNR
38neuroaxonal dystrophy10.1NTF3, NGF
39gastric outlet obstruction10.1MLN, GAST
40duodenogastric reflux10.1GAST, MLN
41ganglioneuroma10.1NGF, NTF3
42diabetic polyneuropathy10.1AKR1B1, NGF, NTF3
43sensory peripheral neuropathy10.1AKR1B1, NGF, NTF3
44dyspepsia10.0MLNR, MLN, GAST
45hyperinsulinemic hypoglycemia10.0INS, GAST
46dumping syndrome10.0MLN, GCG
47rabson-mendenhall syndrome10.0IGF1, INS
48pituitary gland disease10.0IGF1, INS
49duodenal ulcer10.0INS, GAST
50acanthosis nigricans10.0IGF1, INS

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to diabetic autonomic neuropathy

Symptoms for Diabetic Autonomic Neuropathy

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Drugs & Therapeutics for Diabetic Autonomic Neuropathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Autonomic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Autonomic Neuropathy

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Search CenterWatch for Diabetic Autonomic Neuropathy

Genetic Tests for Diabetic Autonomic Neuropathy

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Anatomical Context for Diabetic Autonomic Neuropathy

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34MalaCards
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MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

34
Heart, Testes, Eye, Brain, Skin, Pancreatic islet

Animal Models for Diabetic Autonomic Neuropathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.4NGF, NTF3, INS, EPO, IGF1
2MP:00053788.3INS, NGF, AKR1B1, NTF3, GCG, IGF1
3MP:00053767.1NGF, EPO, AKR1B1, NTF3, GAST, GCG
4MP:00107687.0GCG, NGF, GAST, NTF3, IGF1, INS

Publications for Diabetic Autonomic Neuropathy

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53PubMed
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Articles related to Diabetic Autonomic Neuropathy:

(show top 50)    (show all 280)
idTitleAuthorsYear
1
Diabetic autonomic neuropathy. (23393679)
2012
2
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. (21247746)
2011
3
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. (20156724)
2009
4
Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. (17967455)
2008
5
Ergotamine use in severe diabetic autonomic neuropathy. (17227338)
2007
6
Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. (16389160)
2006
7
Comparative neuropathology and diabetic autonomic neuropathy. (14578168)
2003
8
The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. (12502507)
2003
9
Diabetic autonomic neuropathy causing gall bladder dysfunction. (11848318)
2001
10
Cerebrovascular reactivity and hypercapnic respiratory drive in diabetic autonomic neuropathy. (11181597)
2001
11
Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy. (10746489)
2000
12
Cholecystoparesis with diabetic autonomic neuropathy. (9313105)
1997
13
Correlation of altered Q-T interval and sympathetic nervous system dysfunction in diabetic autonomic neuropathy. (8137835)
1994
14
Circadian rhythmicity of heart rate and QTc interval in diabetic autonomic neuropathy: implications for the mechanism of sudden death. (8438703)
1993
15
Relationship between the circadian rhythms of blood pressure and sympathovagal balance in diabetic autonomic neuropathy. (8243821)
1993
16
Is the corrected QT interval a reliable indicator of the severity of diabetic autonomic neuropathy? (8404428)
1993
17
Early nocturnal blood pressure changes in diabetic autonomic neuropathy assessed by Fourier series. (8292880)
1993
18
A double-blind crossover study of oral xamoterol in postural hypotension due to diabetic autonomic neuropathy. (1688039)
1991
19
QT interval in diabetic autonomic neuropathy. (2147640)
1990
20
Airway responses to deep inspiration in diabetic autonomic neuropathy. (2135213)
1990
21
Abnormal thermoregulation in diabetic autonomic neuropathy. (3384191)
1988
22
Skin microvascular reflexes in patients with diabetic autonomic neuropathy. (3167651)
1988
23
Hypertension caused by clonidine in patients with diabetic autonomic neuropathy. (3608808)
1987
24
Abnormal diurnal urinary sodium and water excretion in diabetic autonomic neuropathy. (3477352)
1987
25
Metabolic and cardiovascular responses to epinephrine in diabetic autonomic neuropathy. (3614285)
1987
26
QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. (3818902)
1987
27
Supersensitivity to both tyramine and noradrenaline in diabetic autonomic neuropathy. (3559608)
1987
28
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
29
Quantitative evaluation of diabetic autonomic neuropathy by using heart rate variations: relationship between cardiac parasympathetic or sympathetic damage and clinical conditions. (3961794)
1986
30
Sympathetic defects in diabetic autonomic neuropathy. (3833449)
1985
31
Increased metabolic sensitivity towards adrenaline in diabetic autonomic neuropathy. (2870836)
1985
32
Norepinephrine secretion and production in diabetic autonomic neuropathy. (6736202)
1984
33
Reduced sinus arrhythmia in diabetic autonomic neuropathy. (6401569)
1983
34
The prevalence of diabetic autonomic neuropathy indicated by abnormal R-R interval variation. (6096985)
1983
35
Axonal dystrophy in experimental diabetic autonomic neuropathy. (7160544)
1982
36
Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies. (6761211)
1982
37
Preservation of the hypoxic drive to breathing in diabetic autonomic neuropathy. (6806003)
1982
38
A new test to study diabetic autonomic neuropathy. (7227703)
1981
39
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
40
Dopamine beta-Hydroxylation in diabetes ane diabetic autonomic neuropathy. (7295304)
1981
41
Gastric emptying in diabetic autonomic neuropathy. (6769774)
1980
42
Clinical features of diabetic autonomic neuropathy. (6929778)
1980
43
Aspects of diabetic autonomic neuropathy. Introduction and workshop summary. (7356217)
1980
44
Diabetic autonomic neuropathy. (387501)
1979
45
Cardiorespiratory arrest and diabetic autonomic neuropathy. (74496)
1978
46
Pupillary signs in diabetic autonomic neuropathy. (709128)
1978
47
Lack of glucagon response to hypoglycemia in diabetic autonomic neuropathy. (838171)
1977
48
The autonomous heart in diabetic autonomic neuropathy. (1036578)
1976
49
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975
50
Defective innervation of heart in diabetic autonomic neuropathy. (1131653)
1975

Variations for Diabetic Autonomic Neuropathy

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Expression for genes affiliated with Diabetic Autonomic Neuropathy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for genes affiliated with Diabetic Autonomic Neuropathy

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN
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Pathways related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9NTF3, NGF
29.8NGF, IGF1
39.7IGF1, INS
49.7IGF1, INS
59.7INS, IGF1
6
Show member pathways
FOXA transcription factor networks39
9.6GCG, INS
7
Show member pathways
9.4INS, IGF1, NGF
8
Show member pathways
9.4NTF3, INS, IGF1
99.3EPO, INS, IGF1
10
Show member pathways
9.2INS, GCG, IGF1
119.0NGF, INS, IGF1, EPO
12
Show member pathways
9.0NTF3, IGF1, EPO, INS
13
Show member pathways
8.2MLNR, GCG, GAST, MLN
14
Show member pathways
7.1GCG, GAST, NGF, INS, MLNR, MLN

Compounds for genes affiliated with Diabetic Autonomic Neuropathy

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1acipimox46 3010.5INS, IGF1, GCG
2aminoguanidine46 30 1211.5AOC1, AKR1B1, EPO
3streptozotocin469.4INS, AKR1B1, NTF3, GCG
4cisapride46 30 1211.3MLNR, GCG, MLN
5levodopa46 1210.2NGF, AOC1, AKR1B1, IGF1
6i-app469.1GCG, GAST, INS
7pirenzepine46 30 1211.1IGF1, GAST, GCG
8vitamin b12469.0GAST, AKR1B1, IGF1, EPO
9bethanechol46 30 1211.0GCG, GAST, MLN
10glycerol46 25 1211.0GCG, AKR1B1, INS, NGF
11ondansetron52 46 25 1212.0EPO, MLN, GAST
12genistein46 30 62 3 25 1214.0NTF3, AKR1B1, NGF, IGF1, GCG
13oxyntomodulin46 629.9MLN, GCG, GAST
14wortmannin468.9NTF3, IGF1, NGF, INS, GCG
15rapamycin468.9IGF1, INS, GCG, EPO, NTF3
16hydrocortisone46 3 62 1211.8EPO, GAST, INS, IGF1
17starch468.8GCG, GAST, INS, IGF1
18carbachol46 30 1210.8GAST, GCG, NGF, NTF3
19c-peptide468.7INS, IGF1, GAST, GCG
20atropine46 30 1210.7MLN, GCG, NGF, GAST
21ly294002468.6INS, NGF, EPO, NTF3, GCG, IGF1
22calcitriol46 62 25 1211.6IGF1, NGF, GAST, EPO
23nifedipine46 30 52 1211.6GAST, MLN, GCG, NGF
24nicotinamide46 129.6INS, EPO, AKR1B1, GAST, GCG
25epinephrine46 25 1210.6GCG, GAST, AKR1B1, INS, NGF
26lactate468.6AOC1, INS, EPO, AKR1B1, GCG
27cycloheximide468.5GCG, NTF3, IGF1, NGF, AKR1B1
28thyroxine46 259.5GAST, NGF, INS, IGF1, MLN
29thymidine46 259.4IGF1, NGF, EPO, NTF3, GAST
30acetylcholine46 52 30 25 1212.4GCG, NGF, MLN, GAST, NTF3
31testosterone46 62 25 1211.3AKR1B1, GAST, EPO, NGF, INS, IGF1
32norepinephrine46 25 1210.3INS, NGF, AKR1B1, GCG, GAST, NTF3
335-hydroxytryptamine468.2MLN, GCG, AOC1, GAST
34gnrh468.1INS, NGF, EPO, IGF1, GAST, GCG
35adenylate468.1GCG, GAST, NTF3, AKR1B1, NGF, MLN
36acth468.0MLN, INS, IGF1, GAST
37octreotide46 62 30 1210.9MLN, GAST, EPO, INS, IGF1, GCG
38glutamine467.9GCG, IGF1, NGF, AKR1B1, AOC1, GAST
39estrogen467.9IGF1, GCG, INS, GAST, AKR1B1, NTF3
40vegf467.9EPO, GAST, NGF, IGF1, AKR1B1, GCG
41glutamate467.8NGF, AOC1, NTF3, INS, GCG, GAST
42histamine46 30 259.8GCG, GAST, MLN, NGF, NTF3, AOC1
43heparin46 30 25 1210.7GCG, MLN, NTF3, AOC1, GAST
44alanine467.6MLN, INS, NGF, GAST, GCG, AKR1B1
45arginine467.6MLN, AOC1, NTF3, NGF, INS, IGF1
46dopamine46 30 25 1210.6NGF, MLNR, MLN, IGF1, GCG, NTF3
47tyrosine467.5IGF1, INS, NGF, EPO, NTF3, GAST
48serine467.5GAST, AKR1B1, NGF, GCG, MLN, IGF1
49creatinine467.2GCG, GAST, AOC1, AKR1B1, EPO, INS
50glucose467.0AOC1, NTF3, AKR1B1, INS, IGF1, MLN

GO Terms for genes affiliated with Diabetic Autonomic Neuropathy

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17Gene Ontology
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Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.6GCG, INS
2extracellular spaceGO:0056157.3IGF1, INS, NGF, EPO, AKR1B1, AOC1
3extracellular regionGO:0055766.8GCG, MLN, IGF1, INS, NGF, EPO

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein autophosphorylationGO:03195410.1NGF, INS
2response to electrical stimulusGO:05160210.1EPO, NGF
3positive regulation of glycolytic processGO:04582110.0INS, IGF1
4positive regulation of Ras protein signal transductionGO:04657910.0IGF1, EPO
5activation of protein kinase B activityGO:03214810.0INS, NTF3
6positive regulation of glycogen biosynthetic processGO:0457259.9INS, IGF1
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9EPO, IGF1
8peripheral nervous system developmentGO:0074229.9NTF3, NGF
9positive regulation of glucose importGO:0463269.8IGF1, INS
10positive regulation of mitosisGO:0458409.8INS, IGF1
11positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7NTF3, INS, IGF1
12positive regulation of DNA replicationGO:0457409.7IGF1, INS, EPO
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7NGF, IGF1
14positive regulation of peptidyl-serine phosphorylationGO:0331389.6NTF3, GCG
15positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4INS, IGF1
16cell-cell signalingGO:0072679.3NTF3, MLN, INS
17positive regulation of cell proliferationGO:0082849.3IGF1, INS, EPO, NTF3
18signal transductionGO:0071658.4GCG, IGF1, GAST, NTF3, EPO
19G-protein coupled receptor signaling pathwayGO:0071868.1GAST, MLN, INS, GCG, MLNR

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.7IGF1, INS
2insulin receptor bindingGO:0051589.4IGF1, INS
3growth factor activityGO:0080839.3NTF3, NGF, IGF1
4receptor bindingGO:0051029.1MLN, NTF3, GCG
5hormone activityGO:0051797.5GAST, INS, GCG, EPO, IGF1, MLN

Products for genes affiliated with Diabetic Autonomic Neuropathy

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  • Antibodies
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Sources for Diabetic Autonomic Neuropathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet