MCID: DBT002
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Diabetic Autonomic Neuropathy malady

Neuronal diseases category
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Summaries for Diabetic Autonomic Neuropathy

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MalaCards based summary: Diabetic Autonomic Neuropathy is related to neuropathy and autonomic neuropathy. An important gene associated with Diabetic Autonomic Neuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Neurotrophic factor-mediated Trk receptor signaling and Id Signaling Pathway. The compounds acipimox and aminoguanidine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and eye, and related mouse phenotypes are normal and growth/size/body.

Aliases & Classifications for Diabetic Autonomic Neuropathy

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Diabetic Autonomic Neuropathy, Aliases & Descriptions:

Name: Diabetic Autonomic Neuropathy 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:11503
NCIt39 C27068
SNOMED-CT57 50620007
MeSH34 D003929

Related Diseases for Diabetic Autonomic Neuropathy

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Diseases related to Diabetic Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.0INS, NGF, AKR1B1, NTF3
2autonomic neuropathy30.6MLN, INS, NGF, EPO, AKR1B1, NTF3
3pheochromocytoma30.5MLN, NGF, NTF3
4vascular disease30.4AKR1B1, NGF, INS
5hypoglycemia29.9MLN, IGF1, INS, AKR1B1, GAST, GCG
6type 1 diabetes mellitus29.6MLNR, IGF1, INS, AKR1B1, GCG
7obesity29.6MLN, IGF1, INS, AKR1B1, GCG
8diabetes mellitus29.4MLN, IGF1, INS, NGF, AKR1B1, GCG
9postural hypotension10.7
10pancreatitis10.6
11duodenitis10.5GAST
12somatostatinoma10.5GAST
13polyneuropathy10.4AKR1B1
14zollinger-ellison syndrome10.4GAST
15laron syndrome10.4IGF1
16rhinitis10.4AOC1
17iritis10.4
18donohue syndrome10.4INS
19fetal macrosomia10.4INS
20corneal disease10.4NGF, AKR1B1
21gallbladder disease10.4MLNR, MLN
22ileus10.4MLNR, MLN
23neuroaxonal dystrophy10.3NGF, NTF3
24gastric outlet obstruction10.3GAST, MLN
25hypertension10.3
26myocardial infarction10.3
27blindness10.3
28duodenogastric reflux10.3MLN, GAST
29ganglioneuroma10.3NTF3, NGF
30demyelinating disease10.3NTF3, NGF
31diabetic polyneuropathy10.2NTF3, AKR1B1, NGF
32sensory peripheral neuropathy10.2NGF, AKR1B1, NTF3
33dyspepsia10.2GAST, MLN, MLNR
34hyperinsulinemic hypoglycemia10.2INS, GAST
35dumping syndrome10.2GCG, MLN
36acute myocardial infarction10.2
37reflex sympathetic dystrophy10.2
38peripheral artery disease10.2
39gastric dilatation10.2
40cerebritis10.2
41artery disease10.2
42esophagitis10.2
43neuroblastoma10.2
44peripheral neuropathy10.2
45autonomic dysfunction10.2
46dysautonomia10.2
47hypoxia10.2
48rabson-mendenhall syndrome10.2IGF1, INS
49pituitary gland disease10.2IGF1, INS
50duodenal ulcer10.2GAST, INS

Graphical network of the top 20 diseases related to Diabetic Autonomic Neuropathy:



Diseases related to diabetic autonomic neuropathy

Symptoms for Diabetic Autonomic Neuropathy

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Drugs & Therapeutics for Diabetic Autonomic Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Diabetic Autonomic Neuropathy

Search NIH Clinical Center for Diabetic Autonomic Neuropathy

Genetic Tests for Diabetic Autonomic Neuropathy

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Anatomical Context for Diabetic Autonomic Neuropathy

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MalaCards organs/tissues related to Diabetic Autonomic Neuropathy:

32
Heart, Testes, Eye, Brain, Skin, Pancreatic islet

Animal Models for Diabetic Autonomic Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Autonomic Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.4IGF1, INS, NGF, EPO, NTF3
2MP:00053788.3GCG, NTF3, AKR1B1, NGF, INS, IGF1
3MP:00053767.1GCG, IGF1, INS, NGF, EPO, AKR1B1
4MP:00107687.0IGF1, INS, NGF, EPO, AKR1B1, NTF3

Publications for Diabetic Autonomic Neuropathy

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Articles related to Diabetic Autonomic Neuropathy:

(show top 50)    (show all 281)
idTitleAuthorsYear
1
Diabetic autonomic neuropathy. (23393679)
2012
2
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. (21247746)
2011
3
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. (20156724)
2009
4
Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. (17967455)
2008
5
Ergotamine use in severe diabetic autonomic neuropathy. (17227338)
2007
6
Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. (16389160)
2006
7
Comparative neuropathology and diabetic autonomic neuropathy. (14578168)
2003
8
The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs. (12502507)
2003
9
Diabetic autonomic neuropathy causing gall bladder dysfunction. (11848318)
2001
10
Cerebrovascular reactivity and hypercapnic respiratory drive in diabetic autonomic neuropathy. (11181597)
2001
11
Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy. (10746489)
2000
12
Cholecystoparesis with diabetic autonomic neuropathy. (9313105)
1997
13
Correlation of altered Q-T interval and sympathetic nervous system dysfunction in diabetic autonomic neuropathy. (8137835)
1994
14
Circadian rhythmicity of heart rate and QTc interval in diabetic autonomic neuropathy: implications for the mechanism of sudden death. (8438703)
1993
15
Relationship between the circadian rhythms of blood pressure and sympathovagal balance in diabetic autonomic neuropathy. (8243821)
1993
16
Is the corrected QT interval a reliable indicator of the severity of diabetic autonomic neuropathy? (8404428)
1993
17
Early nocturnal blood pressure changes in diabetic autonomic neuropathy assessed by Fourier series. (8292880)
1993
18
A double-blind crossover study of oral xamoterol in postural hypotension due to diabetic autonomic neuropathy. (1688039)
1991
19
QT interval in diabetic autonomic neuropathy. (2147640)
1990
20
Airway responses to deep inspiration in diabetic autonomic neuropathy. (2135213)
1990
21
Abnormal thermoregulation in diabetic autonomic neuropathy. (3384191)
1988
22
Skin microvascular reflexes in patients with diabetic autonomic neuropathy. (3167651)
1988
23
Hypertension caused by clonidine in patients with diabetic autonomic neuropathy. (3608808)
1987
24
Abnormal diurnal urinary sodium and water excretion in diabetic autonomic neuropathy. (3477352)
1987
25
Metabolic and cardiovascular responses to epinephrine in diabetic autonomic neuropathy. (3614285)
1987
26
QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. (3818902)
1987
27
Supersensitivity to both tyramine and noradrenaline in diabetic autonomic neuropathy. (3559608)
1987
28
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
29
Quantitative evaluation of diabetic autonomic neuropathy by using heart rate variations: relationship between cardiac parasympathetic or sympathetic damage and clinical conditions. (3961794)
1986
30
Sympathetic defects in diabetic autonomic neuropathy. (3833449)
1985
31
Increased metabolic sensitivity towards adrenaline in diabetic autonomic neuropathy. (2870836)
1985
32
Norepinephrine secretion and production in diabetic autonomic neuropathy. (6736202)
1984
33
Reduced sinus arrhythmia in diabetic autonomic neuropathy. (6401569)
1983
34
The prevalence of diabetic autonomic neuropathy indicated by abnormal R-R interval variation. (6096985)
1983
35
Axonal dystrophy in experimental diabetic autonomic neuropathy. (7160544)
1982
36
Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies. (6761211)
1982
37
Preservation of the hypoxic drive to breathing in diabetic autonomic neuropathy. (6806003)
1982
38
A new test to study diabetic autonomic neuropathy. (7227703)
1981
39
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
40
Dopamine beta-Hydroxylation in diabetes ane diabetic autonomic neuropathy. (7295304)
1981
41
Gastric emptying in diabetic autonomic neuropathy. (6769774)
1980
42
Clinical features of diabetic autonomic neuropathy. (6929778)
1980
43
Aspects of diabetic autonomic neuropathy. Introduction and workshop summary. (7356217)
1980
44
Diabetic autonomic neuropathy. (387501)
1979
45
Cardiorespiratory arrest and diabetic autonomic neuropathy. (74496)
1978
46
Pupillary signs in diabetic autonomic neuropathy. (709128)
1978
47
Lack of glucagon response to hypoglycemia in diabetic autonomic neuropathy. (838171)
1977
48
The autonomous heart in diabetic autonomic neuropathy. (1036578)
1976
49
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975
50
Defective innervation of heart in diabetic autonomic neuropathy. (1131653)
1975

Variations for Diabetic Autonomic Neuropathy

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Expression for genes affiliated with Diabetic Autonomic Neuropathy

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Expression patterns in normal tissues for genes affiliated with Diabetic Autonomic Neuropathy

Search GEO for disease gene expression data for Diabetic Autonomic Neuropathy.

Pathways for genes affiliated with Diabetic Autonomic Neuropathy

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Pathways related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9NTF3, NGF
29.8NGF, IGF1
39.7IGF1, INS
49.7INS, IGF1
59.7INS, IGF1
6
Show member pathways
FOXA transcription factor networks37
9.6INS, GCG
7
Show member pathways
9.4NGF, INS, IGF1
8
Show member pathways
9.4IGF1, INS, NTF3
99.3EPO, INS, IGF1
10
Show member pathways
9.2IGF1, INS, GCG
119.0IGF1, INS, NGF, EPO
12
Show member pathways
9.0IGF1, INS, EPO, NTF3
13
Show member pathways
8.2MLNR, MLN, GAST, GCG
14
Show member pathways
7.1GCG, GAST, NGF, INS, IGF1, MLN

Compounds for genes affiliated with Diabetic Autonomic Neuropathy

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Compounds related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1acipimox44 2810.5INS, IGF1, GCG
2aminoguanidine44 28 1111.5AOC1, AKR1B1, EPO
3streptozotocin449.4INS, AKR1B1, NTF3, GCG
4cisapride44 28 1111.3MLNR, GCG, MLN
5levodopa44 1110.2NGF, AOC1, AKR1B1, IGF1
6i-app449.1GCG, GAST, INS
7pirenzepine44 28 1111.1IGF1, GAST, GCG
8vitamin b12449.0GAST, AKR1B1, IGF1, EPO
9bethanechol44 28 1111.0GCG, GAST, MLN
10glycerol44 24 1111.0GCG, AKR1B1, INS, NGF
11ondansetron50 44 24 1112.0EPO, MLN, GAST
12genistein44 28 61 2 24 1114.0NTF3, AKR1B1, NGF, IGF1, GCG
13oxyntomodulin44 619.9MLN, GCG, GAST
14wortmannin448.9NTF3, IGF1, NGF, INS, GCG
15rapamycin448.9IGF1, INS, GCG, EPO, NTF3
16hydrocortisone44 2 61 1111.8EPO, GAST, INS, IGF1
17starch448.8GCG, GAST, INS, IGF1
18carbachol44 28 1110.8GAST, GCG, NGF, NTF3
19c-peptide448.7INS, IGF1, GAST, GCG
20atropine44 28 1110.7MLN, GCG, NGF, GAST
21ly294002448.6INS, NGF, EPO, NTF3, GCG, IGF1
22calcitriol44 61 24 1111.6IGF1, NGF, GAST, EPO
23nifedipine44 28 50 1111.6GAST, MLN, GCG, NGF
24nicotinamide44 119.6INS, EPO, AKR1B1, GAST, GCG
25epinephrine44 24 1110.6GCG, GAST, AKR1B1, INS, NGF
26lactate448.6AOC1, INS, EPO, AKR1B1, GCG
27cycloheximide448.5GCG, NTF3, IGF1, NGF, AKR1B1
28thyroxine44 249.5GAST, NGF, INS, IGF1, MLN
29thymidine44 249.4IGF1, NGF, EPO, NTF3, GAST
30acetylcholine44 50 28 24 1112.4GCG, NGF, MLN, GAST, NTF3
31testosterone44 61 24 1111.3AKR1B1, GAST, EPO, NGF, INS, IGF1
32norepinephrine44 24 1110.3INS, NGF, AKR1B1, GCG, GAST, NTF3
335-hydroxytryptamine448.2MLN, GCG, AOC1, GAST
34gnrh448.1INS, NGF, EPO, IGF1, GAST, GCG
35adenylate448.1GCG, GAST, NTF3, AKR1B1, NGF, MLN
36acth448.0MLN, INS, IGF1, GAST
37octreotide44 61 28 1110.9MLN, GAST, EPO, INS, IGF1, GCG
38glutamine447.9GCG, IGF1, NGF, AKR1B1, AOC1, GAST
39estrogen447.9IGF1, GCG, INS, GAST, AKR1B1, NTF3
40vegf447.9EPO, GAST, NGF, IGF1, AKR1B1, GCG
41glutamate447.8NGF, AOC1, NTF3, INS, GCG, GAST
42histamine44 28 249.8GCG, GAST, MLN, NGF, NTF3, AOC1
43heparin44 28 24 1110.7GCG, MLN, NTF3, AOC1, GAST
44alanine447.6MLN, INS, NGF, GAST, GCG, AKR1B1
45arginine447.6MLN, AOC1, NTF3, NGF, INS, IGF1
46dopamine44 28 24 1110.6NGF, MLNR, MLN, IGF1, GCG, NTF3
47tyrosine447.5IGF1, INS, NGF, EPO, NTF3, GAST
48serine447.5GAST, AKR1B1, NGF, GCG, MLN, IGF1
49creatinine447.2GCG, GAST, AOC1, AKR1B1, EPO, INS
50glucose447.0AOC1, NTF3, AKR1B1, INS, IGF1, MLN

GO Terms for genes affiliated with Diabetic Autonomic Neuropathy

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Cellular components related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.6GCG, INS
2extracellular spaceGO:0056157.3IGF1, INS, NGF, EPO, AKR1B1, AOC1
3extracellular regionGO:0055766.8GCG, MLN, IGF1, INS, NGF, EPO

Biological processes related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein autophosphorylationGO:03195410.1NGF, INS
2response to electrical stimulusGO:05160210.1EPO, NGF
3positive regulation of glycolytic processGO:04582110.0INS, IGF1
4positive regulation of Ras protein signal transductionGO:04657910.0EPO, IGF1
5activation of protein kinase B activityGO:03214810.0NTF3, INS
6positive regulation of glycogen biosynthetic processGO:0457259.9IGF1, INS
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9IGF1, EPO
8peripheral nervous system developmentGO:0074229.9NTF3, NGF
9positive regulation of glucose importGO:0463269.8INS, IGF1
10positive regulation of mitosisGO:0458409.8IGF1, INS
11positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7NTF3, INS, IGF1
12positive regulation of DNA replicationGO:0457409.7IGF1, INS, EPO
13extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7IGF1, NGF
14positive regulation of peptidyl-serine phosphorylationGO:0331389.6GCG, NTF3
15positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4INS, IGF1
16cell-cell signalingGO:0072679.3NTF3, INS, MLN
17positive regulation of cell proliferationGO:0082849.3IGF1, INS, EPO, NTF3
18signal transductionGO:0071658.4IGF1, EPO, NTF3, GAST, GCG
19G-protein coupled receptor signaling pathwayGO:0071868.1GCG, GAST, INS, MLN, MLNR

Molecular functions related to Diabetic Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.7INS, IGF1
2insulin receptor bindingGO:0051589.4INS, IGF1
3growth factor activityGO:0080839.3IGF1, NGF, NTF3
4receptor bindingGO:0051029.1GCG, NTF3, MLN
5hormone activityGO:0051797.5GCG, GAST, EPO, INS, IGF1, MLN

Products for genes affiliated with Diabetic Autonomic Neuropathy

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Sources for Diabetic Autonomic Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet