MCID: DBT007
MIFTS: 36

Diabetic Cataract malady

Eye category

Summaries for Diabetic Cataract

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33MalaCards
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MalaCards: Diabetic Cataract, also known as cataract - diabetic, is related to neuropathy and iron deficiency anemia. An important gene associated with Diabetic Cataract is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are superoxide radicals degradation and acetone degradation I (to methylglyoxal). The compounds uric acid and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotype vision/eye.

Aliases & Classifications for Diabetic Cataract

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

diabetic cataract 8 10 45 61
cataract - diabetic 8


External Ids:

Disease Ontology8 DOID:13328
ICD9CM27 366.41
ICD1025 H28.0

Related Diseases for Diabetic Cataract

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy10.0AKR1B1
2iron deficiency anemia10.0G6PD
3viral hepatitis10.0G6PD
4thalassemia10.0G6PD
5goiter10.0CAT
6duodenal ulcer10.0GSR
7diabetic polyneuropathy10.0AKR1B1
8hepatoblastoma10.0CAT
9gastric ulcer10.0GSR
10meningitis10.0CAT
11pneumonia10.0MIP
12galactosemia10.0CAT
13friedreich ataxia10.0GSR
14favism10.0G6PD
15ovarian cancer10.0SERPINF1
16uveitis10.0SERPINF1
17methemoglobinemia10.0GSR, G6PD
18vascular disease10.0CAT, GSR
19encephalitis10.0CAT
20acute myocardial infarction10.0GSR, CAT
21blindness10.0SERPINF1, AKR1B1
22eales disease10.0SOD1
23glucosephosphate dehydrogenase deficiency10.0GSR, G6PD
24aceruloplasminemia10.0CP
25hyperhomocysteinemia10.0SOD1
26down syndrome10.0SOD1
27pancreatitis10.0SOD1
28proliferative diabetic retinopathy10.0SERPINF1
29osteoarthritis10.0G6PD, GSR
30psoriasis10.0PPARD
31acute pancreatitis10.0SOD1
32hypermethioninemia10.0SOD1
33wilms tumor10.0SERPINF1
34microcytic anemia10.0G6PD
35retinal vascular disease10.0SERPINF1, AKR1B1
36hemosiderosis10.0CP
37prion disease10.0CP, CAT
38adenocarcinoma10.0SERPINF1
39bronchopulmonary dysplasia10.0SOD1
40coronary heart disease10.0PPARD, GSR
41glaucoma10.0AKR1B1, MIP, SERPINF1
42asthma10.0GSR, CP
43amyotrophic lateral sclerosis10.0GSR, SOD1
44hepatitis c10.0GSR
45dementia10.0GSR, CP
46essential hypertension10.0SOD1, GSR
47insulin resistance10.0MIP, PPARD
48brain edema10.0MIP, SOD1
49tuberculosis10.0GSR, CP
50myocardial infarction10.0GSR, AKR1B1, PPARD

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to diabetic cataract

Clinical Features for Diabetic Cataract

Drugs & Therapeutics for Diabetic Cataract

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Cataract

Drug clinical trials:

Search ClinicalTrials for Diabetic Cataract

Search NIH Clinical Center for Diabetic Cataract

Search CenterWatch for Diabetic Cataract

Genetic Tests for Diabetic Cataract

Anatomical Context for Diabetic Cataract

Sources:
33MalaCards
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MalaCards organs/tissues related to Diabetic Cataract:

33
B cells

Animal Models for Diabetic Cataract or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Diabetic Cataract:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.2GSR, CP, SERPINF1, MIP, AKR1B1, CRYGS

Publications for Diabetic Cataract

Sources:
51PubMed
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Articles related to Diabetic Cataract:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Xanthine oxidase and lens oxidative stress markers in diabetic and senile cataract patients. (23142692)
2013
2
Macular edema after cataract surgery in eyes without preoperative central-involved diabetic macular edema. (23599174)
2013
3
Prophylactic postoperative ketorolac improves outcomes in diabetic patients assigned for cataract surgery. (23836953)
2013
4
Incidence of visual impairment due to cataract, diabetic retinopathy and trachoma in indigenous Australians within central Australia: the Central Australian Ocular Health Study. (22594763)
2013
5
Aqueous cytokines as predictors of macular edema in non-diabetic patients following uncomplicated phacoemulsification cataract surgery. (24319335)
2013
6
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. (22407349)
2012
7
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. (23365598)
2012
8
Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy. (22927737)
2012
9
Ranibizumab in patients with dense cataract and proliferative diabetic retinopathy with rubeosis. (23439790)
2012
10
Intravitreal injection of ranibizumab during cataract surgery in patients with diabetic macular edema. (22495327)
2012
11
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. (20806076)
2010
12
Prevention of vision loss after cataract surgery in diabetic macular edema with intravitreal bevacizumab: a pilot study. (20827155)
2010
13
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. (18982249)
2009
14
The combination of intravitreal bevacizumab and phacoemulsification surgery in patients with cataract and coexisting diabetic macular edema. (19232012)
2009
15
Elevated Expression of indoleamine 2,3-dioxygenase (IDO) and accumulation of kynurenic acid in the pathogenesis of STZ-induced diabetic cataract in Wistar rats. (19373575)
2009
16
Changes in erythrocyte glucose-6-phosphate dehydrogenase (G6PD) and reduced glutathione (GSH) activities in the development of senile and diabetic cataracts. (19058613)
2008
17
Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract. (17466963)
2007
18
Efficacy of alpha-lipoic acid against diabetic cataract in rat. (17295134)
2007
19
Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. (17679931)
2007
20
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. (17240813)
2006
21
Acute irreversible diabetic cataract in adolescence: a case report. (15877100)
2006
22
Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. (15682043)
2005
23
Prevention of cataract by pyruvate in experimentally diabetic mice. (15786723)
2005
24
Inhibition of experimental diabetic cataract by topical administration of RS-verapamil hydrochloride. (14693771)
2004
25
Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract. (12882795)
2003
26
Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235. (12140204)
2002
27
Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. (12458487)
2002
28
Contribution of ubiquitous calpains to cataractogenesis in the spontaneous diabetic WBN/Kob rat. (12457873)
2002
29
Lens superoxide dismutase and catalase activities in diabetic cataract. (11937081)
2002
30
Diabetic cataract and the total antioxidant status in aqueous humor. (11341748)
2001
31
Diabetic cataract in children. (9591961)
1998
32
Lens lipid peroxides and glutathione concentrations in diabetic cataract. (9133255)
1997
33
Effects of a novel potent aldose reductase inhibitor, GP-1447, on aldose reductase activity in vitro and on diabetic neuropathy and cataract formation in rats. (9074947)
1997
34
Lens lipid peroxides in diabetic cataract. (9367014)
1997
35
A technical approach to the evaluation of glucose oxidation: implications for diabetic cataract. (8979275)
1996
36
Modelling cortical cataractogenesis. XVIII. In vitro diabetic cataract reduction by venoruton. A flavonoid which prevents lens opacification. (8883554)
1996
37
Metabolic control of non-insulin-dependent diabetic patients undergoing cataract surgery: comparison of local and general anaesthesia. (7772420)
1995
38
Human diabetic cataract: role of lipid peroxidation. (7556808)
1995
39
Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation. (8336207)
1993
40
RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains. (8104833)
1993
41
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1821625)
1991
42
Regional enzymatic analysis of UV-B and streptozotocin induced diabetic cataract lens. (1966039)
1990
43
Neovascular glaucoma after intracapsular and extracapsular cataract extraction in diabetic patients. (2414993)
1985
44
Xanthone-2-carboxylic acid effect on lens growth, hydration and proteins during diabetic cataract development. (6817723)
1982
45
Prevalence of senile cataract, diabetic retinopathy, senile macular degeneration, and open-angle glaucoma in the Framingham eye study. (619683)
1978
46
Metabolic pathways in experimental diabetic cataract. (14464237)
1962
47
Effect of partial starvation on development of diabetic cataract. (13237254)
1954
48
(a) Diabetic Cataract; (b) Endocrine Cataract. (19993468)
1947
49
True Diabetic Cataract. (19987219)
1929
50
Two Cases of True Diabetic Cataract. (19986092)
1927

Genetic Variations for Diabetic Cataract

Expression for genes affiliated with Diabetic Cataract

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for genes affiliated with Diabetic Cataract

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 30KEGG
See all sources

Pathways related to Diabetic Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CAT, SOD1
2
Hide members
9.8AKR1B1, AKR1B10
39.7CAT, SOD1, GSR
49.7GSR, SOD1, CAT
59.7GSR, SOD1, CAT
6
Hide members
9.7AKR1B1, SORD
79.1AKR1B1, AKR1B10, SORD

Compounds for genes affiliated with Diabetic Cataract

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Diabetic Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1uric acid45 2411.7G6PD
2alpha tocopherol4510.7G6PD
3fenton4510.6CP
4glutathion4510.6GSR
5nadph45 2411.5G6PD
6gssg4510.5GSR, G6PD
7diphenyleneiodonium4510.2SOD1, SERPINF1
8ionol4510.2SOD1, CAT, GSR
9randox4510.1CP, GSR, SOD1
10propyl gallate4510.1CAT, SOD1, GSR
11dmpo-oh4510.1CP, SOD1, CAT
12guaiacol45 2411.0CAT, SOD1, GSR
13dmpo4510.0CP, SOD1, CAT
143-amino-1,2,4-triazole4510.0CAT, SOD1, GSR
15tolrestat45 1111.0AKR1B10, AKR1B1, GSR
16d penicillamine459.9GSR, CAT, CP
17sodium azide459.9CAT, SOD1, CP, G6PD
18gsno459.9CAT, SOD1, AKR1B1, GSR
19mannitol45 1110.9SORD, CAT, AKR1B1
20silymarin459.9SOD1, AKR1B1, CAT, GSR
21azide459.9CAT, CP, SOD1
22s-nitroso-n-acetylpenicillamine459.8CP, CAT, SOD1, AKR1B1
23benzyl alcohol45 1110.8AKR1B1, SOD1, CAT
24hypoxanthine45 11 2411.8CAT, SOD1, CP, G6PD
25alpha lipoic acid459.8CAT, G6PD, SOD1, GSR, AKR1B1
264-hydroxynonenal45 2410.8G6PD, CAT, GSR, AKR1B1, SOD1
27ebselen459.7CAT, SOD1, GSR
28thiobarbituric acid459.7G6PD, GSR, CAT, SOD1, CP
29dehydroascorbic acid45 1110.7CAT, CP, G6PD, GSR, SOD1
30tocopherol459.7CP, CAT, SOD1, G6PD, GSR
31selenium45 2410.7GSR, SOD1, CP, CAT
32malondialdehyde459.7GSR, CAT, G6PD, CP, SOD1
33betacarotene459.7GSR, SOD1, CAT, CP
34dtpa459.7CP, SOD1, CAT
35vitamin-e459.7G6PD, CAT, GSR, CP, SOD1
36nadp+459.6GSR, AKR1B1, SORD, G6PD
37menadione45 11 2411.6GSR, CAT, SOD1, KEAP1
38oxygen45 2410.5SERPINF1, MIP, AKR1B1, KEAP1, PPARD
39glucose 6-phosphate45 2410.5SORD, G6PD, CAT, SOD1
40n acetylcysteine459.5CAT, AKR1B1, GSR, G6PD, SOD1, SERPINF1
41sodium arsenite459.5GSR, CAT, SOD1, SORD
42ascorbic acid45 2410.5G6PD, SOD1, AKR1B1, CP, GSR, CAT
43levodopa45 1110.4CP, AKR1B1, SOD1, CAT
44indomethacin45 60 29 1112.3PPARD, GSR, CP, CAT, AKR1B1, SOD1
45nadh45 11 2411.1CAT, SORD, G6PD, GSR, AKR1B1, SOD1
46superoxide45 249.8SOD1, CAT, SORD, G6PD, CP, GSR
47lactate458.7CP, SORD, MIP, AKR1B1, G6PD, SOD1
48h2o2458.7MIP, CP, GSR, SOD1, AKR1B1, KEAP1
49creatinine458.4CP, AKR1B1, G6PD, SORD, GSR, SOD1
50cysteine458.4VARS, SERPINF1, CP, GSR, MIP, KEAP1

GO Terms for genes affiliated with Diabetic Cataract

Sources:
16Gene Ontology
See all sources

Biological processes related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1doxorubicin metabolic processGO:0445989.8AKR1B1, AKR1B10
2glutathione metabolic processGO:0067499.7GSR, G6PD, SOD1
3daunorubicin metabolic processGO:0445979.5AKR1B1, AKR1B10

Molecular functions related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aldo-keto reductase (NADP) activityGO:0040339.8AKR1B1, AKR1B10
2NADP bindingGO:0506619.5GSR, G6PD, CAT

Products for genes affiliated with Diabetic Cataract

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Sources for Diabetic Cataract

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet