Aliases & Classifications for Diabetic Cataract

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Diabetic Cataract, Aliases & Descriptions:

Name: Diabetic Cataract 9 11 43 60
 
Cataract - Diabetic 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:13328
ICD9CM27 366.41
ICD1025 H28.0

Summaries for Diabetic Cataract

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MalaCards based summary: Diabetic Cataract, also known as cataract - diabetic, is related to cataract and hyperglycemia. An important gene associated with Diabetic Cataract is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Sulfation Biotransformation Reaction and Fructose and mannose metabolism. The compounds tert-butylhydroperoxide and ionol have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Related Diseases for Diabetic Cataract

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Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1cataract30.4GSR, SERPINF1, SOD1, AKR1B1, MIP, CAT
2hyperglycemia29.5CAT, AKR1B1, SORD, SOD1, SERPINF1
3senile cataract29.5SOD1, GSR, CAT, MIP, G6PD, SERPINF1
4favism10.5G6PD
5diabetic macular edema10.4SERPINF1
6methemoglobinemia10.4G6PD, GSR
7eales disease10.4SOD1
8hypermethioninemia10.4SOD1
9galactosemia10.4AKR1B1, G6PD
10glucosephosphate dehydrogenase deficiency10.4GSR, G6PD
11thalassemia, hispanic gamma-delta-beta10.3G6PD, GSR
12retinal vascular disease10.3AKR1B1, SERPINF1
13plasmodium falciparum malaria10.3G6PD, GSR
14respiratory failure10.3CAT, G6PD
15pneumoconiosis10.2CAT, SOD1
16brain edema10.2SOD1, MIP
17acute kidney failure10.2CAT, G6PD
18alcoholic liver cirrhosis10.2SOD1, CAT
19primary hyperoxaluria10.2G6PD, GSR, MIP
20microvascular complications of diabetes 310.2AKR1B1, SERPINF1, CAT
21wilson disease10.1CAT, G6PD, SOD1
22chronic granulomatous disease10.1CAT, G6PD, SOD1
23malaria10.1MIP, G6PD, GSR
24neuropathy10.1
25premature aging okamoto type10.1
26metabolic syndrome x10.1G6PD, AKR1B1, PPARD
27congenital heart disease10.1GSR, G6PD, MIP
28stroke, ischemic10.1AKR1B1, MIP, GSR
29lymphopenia10.1CAT, GSR
30male infertility10.0SOD1, CAT
31vitiligo-associated multiple autoimmune disease susceptibility 110.0SOD1, G6PD, CAT, GSR
32myocardial infarction10.0GSR, PPARD, AKR1B1
33chronic kidney failure10.0CAT, SOD1, AKR1B1, GSR
34diabetes mellitus, noninsulin-dependent10.0SOD1, GSR, CAT, AKR1B1
35erythrokeratodermia variabilis et progressiva10.0
36obesity10.0
37trachoma10.0
38open-angle glaucoma10.0
39retinitis10.0
40turner syndrome10.0
41parkinson disease, late-onset9.9GSR, CAT, SOD1, SERPINF1
42vascular disease9.9GSR, AKR1B1, G6PD, SOD1, CAT
43malignant glioma9.9GSR, G6PD, SERPINF1, CAT, MIP
44ischemia9.9SOD1, MIP, CAT, GSR, AKR1B1
45microvascular complications of diabetes 59.8SERPINF1, SOD1, SORD, AKR1B1
46melanoma9.8CAT, AKR1B1, SERPINF1, PPARD
47alzheimer disease9.7GSR, PPARD, SERPINF1, SOD1, CAT
48atherosclerosis9.6SOD1, G6PD, AKR1B1, CAT, PPARD, SERPINF1
49diabetes mellitus, insulin-dependent9.4SORD, G6PD, GSR, CAT, AKR1B1, PPARD

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to diabetic cataract

Symptoms for Diabetic Cataract

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Drugs & Therapeutics for Diabetic Cataract

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Drug clinical trials:

Search ClinicalTrials for Diabetic Cataract

Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

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Anatomical Context for Diabetic Cataract

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MalaCards organs/tissues related to Diabetic Cataract:

31
Eye

Animal Models for Diabetic Cataract or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Cataract:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.7GSR, MIP, AKR1B1, SORD, SOD1, SERPINF1
2MP:00053767.6SOD1, SORD, G6PD, AKR1B1, CAT, KEAP1

Publications for Diabetic Cataract

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Articles related to Diabetic Cataract:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats. (25892780)
2015
2
Retraction. Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265. (24722247)
2014
3
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. (25257692)
2014
4
Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract. (25314260)
2014
5
Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. (24527449)
2014
6
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. (23137000)
2013
7
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. (23671855)
2013
8
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. (22407349)
2012
9
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. (23365598)
2012
10
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. (22687477)
2012
11
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. (20806076)
2010
12
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. (19898641)
2009
13
Delay of diabetic cataract in rats by the antiglycating potential of cumin through modulation of alpha-crystallin chaperone activity. (18789666)
2009
14
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. (18490958)
2008
15
Potential use of hirudin in diabetic cataract: a study of galactose mediated human lens epithelial cells injury. (18400216)
2008
16
Efficacy of alpha-lipoic acid against diabetic cataract in rat. (17295134)
2007
17
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. (17240813)
2006
18
Correlation between adult diabetic cataracts and red blood cell aldose reductase levels. (16639016)
2006
19
Acute irreversible diabetic cataract in adolescence: a case report. (15877100)
2006
20
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress. (16797533)
2006
21
Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. (15682043)
2005
22
Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract. (12882795)
2003
23
Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies. (12630936)
2003
24
Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. (12458487)
2002
25
Blood and lens lipid peroxidation and antioxidant status in normal individuals, senile and diabetic cataractous patients. (12518238)
2002
26
Contributions of polyol pathway to oxidative stress in diabetic cataract. (9872926)
1999
27
Acceleration of development of diabetic cataract by hyperlipidemia and low high-density lipoprotein in rats. (9989659)
1999
28
Type I diabetic cataract. (10037586)
1999
29
Diabetic cataract in children. (9591961)
1998
30
Lens lipid peroxides and glutathione concentrations in diabetic cataract. (9133255)
1997
31
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract. (9323307)
1997
32
The diabetic cataract: an unusual presentation in a young subject: case report. (9201605)
1997
33
Modelling cortical cataractogenesis. 13. Early effects on lens ATP/ADP and glutathione in the streptozotocin rat model of the diabetic cataract. (8462652)
1993
34
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1628701)
1992
35
Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance]. (1908617)
1991
36
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat. (1898618)
1991
37
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1821625)
1991
38
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract. (1834606)
1991
39
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. (3917257)
1985
40
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. (6226909)
1983
41
Studies on diabetic cataract in rats induced by streptozotocin. I. Photodocumentation of lens opacification. (6226908)
1983
42
Sorbinil protection of lens protein components and cell hydration during diabetic cataract formation. (6803262)
1982
43
Diabetic cataract formation: potential role of glycosylation of lens crystallins. (275862)
1978
44
Model reproduction of diabetic cataract in vitro. (5786891)
1969
45
Biochemistry of the diabetic cataract. (5266937)
1969
46
Metabolic pathways in experimental diabetic cataract. (14464237)
1962
47
Effect of partial starvation on development of diabetic cataract. (13237254)
1954
48
Diabetic cataract. (20265649)
1947
49
(a) Diabetic Cataract; (b) Endocrine Cataract. (19993468)
1947
50
True Diabetic Cataract. (19987219)
1929

Variations for Diabetic Cataract

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Expression for genes affiliated with Diabetic Cataract

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Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for genes affiliated with Diabetic Cataract

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Pathways related to Diabetic Cataract according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9G6PD, GSR
2
Show member pathways
Polyol pathway36
GDP-L-fucose biosynthesis II (from L-fucose)36
sorbitol degradation I36
9.7SORD, AKR1B1
3
Show member pathways
Vitamin B12 Metabolism36
9.5CAT, SOD1
49.5SOD1, CAT
5
Show member pathways
9.5CAT, SOD1
6
Show member pathways
9.2GSR, CAT, SOD1
7
Show member pathways
9.2GSR, CAT, SOD1
8
Show member pathways
thioredoxin pathway36
9.2GSR, CAT, SOD1
99.2GSR, CAT, SOD1

Compounds for genes affiliated with Diabetic Cataract

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 59Tocris Bioscience, 28IUPHAR
See all sources

Compounds related to Diabetic Cataract according to GeneCards Suite gene sharing:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1tert-butylhydroperoxide439.8G6PD, CAT, GSR
2ionol439.6GSR, CAT, SOD1
3propyl gallate439.6GSR, CAT, SOD1
4guaiacol43 2410.6SOD1, CAT, GSR
5glutathion439.6SOD1, CAT, GSR
63-amino-1,2,4-triazole439.6GSR, CAT, SOD1
7sodium azide439.6SOD1, G6PD, CAT
8benzyl alcohol43 1210.6SOD1, AKR1B1, CAT
9fenton439.6GSR, CAT, SOD1
10probucol43 1210.5CAT, AKR1B1, SOD1
11ebselen439.5SOD1, CAT, GSR
12bathocuproine439.5CAT, SOD1
13nadp+439.5SORD, G6PD, AKR1B1, GSR
14selenite439.5SOD1, CAT, GSR
15tetrahydrobiopterin43 24 1211.5SOD1, AKR1B1, CAT
16NADP249.5G6PD, AKR1B1, CAT, GSR
17ubiquinone439.4GSR, CAT, SOD1
18thiobarbituric acid439.4SOD1, G6PD, CAT, GSR
19dehydroascorbic acid43 1210.4GSR, CAT, G6PD, SOD1
20gsno439.4SOD1, AKR1B1, CAT, GSR
21tocopherol439.4GSR, CAT, G6PD, SOD1
22gssg439.4SOD1, G6PD, CAT, GSR
23silymarin439.4SOD1, AKR1B1, CAT, GSR
24tbhq439.3CAT, GSR, KEAP1
25malondialdehyde439.3SOD1, G6PD, CAT, GSR
26uric acid43 2410.3SOD1, G6PD, CAT, GSR
27vitamin-e439.3GSR, CAT, G6PD, SOD1
28diphenyleneiodonium439.3SERPINF1, SOD1, G6PD, CAT
29trientine439.3GSR, SOD1
30alpha tocopherol439.2SOD1, G6PD, CAT, GSR
31quercetin43 59 24 1212.2GSR, CAT, AKR1B1, SOD1
32menadione43 24 1211.2KEAP1, GSR, CAT, SOD1
33alpha lipoic acid439.1SOD1, G6PD, AKR1B1, CAT, GSR
34sodium arsenite439.1GSR, CAT, SORD, SOD1
354-hydroxynonenal43 2410.1SOD1, G6PD, AKR1B1, CAT, GSR
36ascorbic acid43 2410.0SOD1, G6PD, AKR1B1, CAT, GSR
37arsenite43 2410.0SOD1, MIP, CAT, GSR
38glucose 6-phosphate43 249.9SOD1, SORD, G6PD, CAT, GSR
39indomethacin43 28 59 1211.9PPARD, SOD1, AKR1B1, CAT, GSR
40n acetylcysteine438.7SERPINF1, SOD1, G6PD, AKR1B1, CAT, GSR
41nadph43 249.7SERPINF1, SOD1, G6PD, AKR1B1, CAT, GSR
42superoxide43 249.6GSR, CAT, G6PD, SORD, SOD1
43creatinine438.6GSR, AKR1B1, G6PD, SORD, SOD1
44nadh43 24 1210.6SOD1, SORD, G6PD, AKR1B1, CAT, GSR
45mannitol43 129.6SOD1, SORD, G6PD, AKR1B1, MIP, CAT
46lactate438.3SOD1, SORD, G6PD, AKR1B1, MIP, CAT
47glucose438.2PPARD, SERPINF1, SORD, G6PD, AKR1B1, MIP
48cysteine438.2SERPINF1, SOD1, AKR1B1, MIP, CAT, GSR
49h2o2438.0SERPINF1, SOD1, G6PD, AKR1B1, MIP, CAT
50oxygen43 248.5KEAP1, PPARD, SERPINF1, SOD1, G6PD, AKR1B1

GO Terms for genes affiliated with Diabetic Cataract

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Cellular components related to Diabetic Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.1GSR, AKR1B1, G6PD, SORD, SOD1, SERPINF1

Biological processes related to Diabetic Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.7CAT, PPARD
2glutathione metabolic processGO:00067499.2GSR, G6PD, SOD1
3embryo implantationGO:00075669.1SOD1, PPARD

Molecular functions related to Diabetic Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:00506619.6GSR, CAT, G6PD

Products for genes affiliated with Diabetic Cataract

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Sources for Diabetic Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet