Aliases & Classifications for Diabetic Cataract

MalaCards integrated aliases for Diabetic Cataract:

Name: Diabetic Cataract 12 51 14 69
Cataract - Diabetic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13328
ICD9CM 34 366.41
ICD10 32 H28.0
UMLS 69 C0011876

Summaries for Diabetic Cataract

MalaCards based summary : Diabetic Cataract, also known as cataract - diabetic, is related to turner syndrome and premature aging syndrome, okamoto type. An important gene associated with Diabetic Cataract is AKR1B1 (Aldo-Keto Reductase Family 1 Member B), and among its related pathways/superpathways are Pathways in cancer and HIF-1-alpha transcription factor network. The drugs Ketorolac and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Diabetic Cataract

Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 turner syndrome 10.8
2 premature aging syndrome, okamoto type 10.8
3 cataract 10.6
4 macular retinal edema 10.1 SERPINF1 VEGFA
5 central retinal vein occlusion 10.1 SERPINF1 VEGFA
6 diabetic polyneuropathy 10.1 AKR1B1 VEGFA
7 macular holes 10.1 SERPINF1 VEGFA
8 lymphangioma 10.0 SERPINF1 VEGFA
9 diabetic macular edema 10.0 SERPINF1 VEGFA
10 retinal vein occlusion 10.0 SERPINF1 VEGFA
11 corneal neovascularization 9.9 SERPINF1 VEGFA
12 retinal ischemia 9.9 CAT VEGFA
13 microvascular complications of diabetes 1 9.9 SERPINF1 VEGFA
14 retinal vascular disease 9.9 AKR1B1 SERPINF1 VEGFA
15 microvascular complications of diabetes 5 9.9 AKR1B1 SERPINF1 VEGFA
16 hepatopulmonary syndrome 9.8 NOS2 VEGFA
17 hyperphenylalaninemia 9.8 CACNA1C CAT
18 neuropathy 9.7
19 eales disease 9.7 NOS2 SERPINF1 VEGFA
20 diabetes mellitus, noninsulin-dependent 9.6
21 body mass index quantitative trait locus 11 9.6
22 aging 9.6
23 body mass index quantitative trait locus 9 9.6
24 body mass index quantitative trait locus 8 9.6
25 body mass index quantitative trait locus 4 9.6
26 body mass index quantitative trait locus 10 9.6
27 body mass index quantitative trait locus 7 9.6
28 body mass index quantitative trait locus 12 9.6
29 body mass index quantitative trait locus 14 9.6
30 body mass index quantitative trait locus 18 9.6
31 diabetes mellitus 9.6
32 retinitis 9.6
33 hyperglycemia 9.6
34 vascular disease 9.6 CAT NOS2 VEGFA
35 male reproductive organ cancer 9.6 AR VEGFA
36 lens disease 9.5 AKR1B1 GBA3 VEGFA
37 pre-eclampsia 9.5 CAT NOS2 VEGFA

Comorbidity relations with Diabetic Cataract via Phenotypic Disease Network (PDN):


Acute Cystitis Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to Diabetic Cataract

Symptoms & Phenotypes for Diabetic Cataract

MGI Mouse Phenotypes related to Diabetic Cataract:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 PPARD AKR1B1 AR VEGFA CACNA1C CAT
2 digestive/alimentary MP:0005381 9.8 PPARD SERPINF1 AR VEGFA NOS2
3 integument MP:0010771 9.72 PPARD AR VEGFA CACNA1C NOS2
4 muscle MP:0005369 9.65 PPARD AR VEGFA CACNA1C NOS2
5 neoplasm MP:0002006 9.55 PPARD AR VEGFA CAT NOS2
6 reproductive system MP:0005389 9.43 PPARD SERPINF1 AR VEGFA CACNA1C NOS2
7 skeleton MP:0005390 9.1 PPARD AKR1B1 SERPINF1 AR VEGFA NOS2

Drugs & Therapeutics for Diabetic Cataract

Drugs for Diabetic Cataract (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Antirheumatic Agents Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Ketorolac Tromethamine Phase 4
9 Peripheral Nervous System Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protein Profile of Immunoregulatory Factors in Diabetic Cataract Completed NCT01832311 Phase 4 Ketorolac

Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

Anatomical Context for Diabetic Cataract

MalaCards organs/tissues related to Diabetic Cataract:

38
Eye

Publications for Diabetic Cataract

Articles related to Diabetic Cataract:

(show top 50) (show all 115)
# Title Authors Year
1
Interaction of AR and iNOS in lens epithelial cell: A new pathogenesis and potential therapeutic targets of diabetic cataract. ( 28108234 )
2017
2
MiR-30a inhibits BECN1-mediated autophagy in diabetic cataract. ( 29100392 )
2017
3
Effect of Oral Alpha Lipoic Acid in Preventing the Genesis of Canine Diabetic Cataract: A Preliminary Study. ( 29056677 )
2017
4
Does oxidative stress play any role in diabetic cataract formation? ----Re-evaluation using a thioltransferase gene knockout mouse model. ( 28579033 )
2017
5
Effects of microRNA-211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice. ( 28679650 )
2017
6
Clinical evaluation of corneal changes after phacoemulsification in diabetic and non-diabetic cataract patients, a systematic review and meta-analysis. ( 29074989 )
2017
7
Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression. ( 28065730 )
2017
8
Protective effect of Tephrosia purpurea in diabetic cataract through aldose reductase inhibitory activity. ( 27372406 )
2016
9
Calpain and Caspase-12 Expression in Lens Epithelial Cells of Diabetic Cataracts. ( 27130368 )
2016
10
Featured Article: Inhibition of diabetic cataract by glucose tolerance factor extracted from yeast. ( 26825353 )
2016
11
A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract. ( 27124316 )
2016
12
Structure-Activity Relationship Study Reveals Benzazepine Derivatives of Luteolin as New Aldose Reductase Inhibitors for Diabetic Cataract. ( 27396410 )
2016
13
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. ( 27520089 )
2016
14
DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. ( 26759189 )
2016
15
Inhibitory Effect of Crocin(s) on Lens I+-Crystallin Glycation and Aggregation, Results in the Decrease of the Risk of Diabetic Cataract. ( 26821002 )
2016
16
Characterization of Emodin as a Therapeutic Agent for Diabetic Cataract. ( 27140653 )
2016
17
Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract. ( 26517726 )
2015
18
Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats. ( 25892780 )
2015
19
Corneal Bullous Epithelial Detachment in Diabetic Cataract Surgery. ( 26002007 )
2015
20
Differential Protein Expression between Type 1 Diabetic Cataract and Age-Related Cataract Patients. ( 26333124 )
2015
21
Protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat. ( 25902031 )
2015
22
Expression of p53 and caspase-8 in lens epithelial cells of diabetic cataract. ( 24957431 )
2014
23
Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract. ( 25314260 )
2014
24
Effects of two antioxidants; I+-lipoic acid and fisetin against diabetic cataract in mice. ( 25488016 )
2014
25
Retraction. Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265. ( 24722247 )
2014
26
Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. ( 24527449 )
2014
27
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. ( 25257692 )
2014
28
Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract. ( 23827758 )
2013
29
Early phacoemulsification in diabetic cataract for early recognition and management of diabetic macular oedema. ( 23763799 )
2013
30
Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. ( 24136906 )
2013
31
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. ( 23671855 )
2013
32
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. ( 23137000 )
2013
33
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. ( 22687477 )
2012
34
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. ( 22407349 )
2012
35
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. ( 23365598 )
2012
36
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses. ( 22683333 )
2012
37
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. ( 21271438 )
2011
38
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. ( 21753902 )
2011
39
Diabetic cataract-pathogenesis, epidemiology and treatment. ( 20634936 )
2010
40
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. ( 20806076 )
2010
41
Relationship between Pentosidine and Pyridinoline Levels in Human Diabetic Cataract Lenses. ( 21103032 )
2010
42
Delay of diabetic cataract in rats by the antiglycating potential of cumin through modulation of alpha-crystallin chaperone activity. ( 18789666 )
2009
43
Influence of selected angiotensin-converting enzyme inhibitors on alloxan-induced diabetic cataract in rabbits. ( 19865050 )
2009
44
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. ( 19898641 )
2009
45
Elevated Expression of indoleamine 2,3-dioxygenase (IDO) and accumulation of kynurenic acid in the pathogenesis of STZ-induced diabetic cataract in Wistar rats. ( 19373575 )
2009
46
Potential use of hirudin in diabetic cataract: a study of galactose mediated human lens epithelial cells injury. ( 18400216 )
2008
47
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. ( 18490958 )
2008
48
Changes in erythrocyte glucose-6-phosphate dehydrogenase (G6PD) and reduced glutathione (GSH) activities in the development of senile and diabetic cataracts. ( 19058613 )
2008
49
Efficacy of alpha-lipoic acid against diabetic cataract in rat. ( 17295134 )
2007
50
Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. ( 17679931 )
2007

Variations for Diabetic Cataract

Expression for Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for Diabetic Cataract

GO Terms for Diabetic Cataract

Biological processes related to Diabetic Cataract according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.58 NOS2 SERPINF1 VEGFA
2 negative regulation of apoptotic process GO:0043066 9.56 AKR1B1 CAT PPARD VEGFA
3 negative regulation of epithelial cell proliferation GO:0050680 9.51 AR PPARD
4 response to hypoxia GO:0001666 9.5 CAT NOS2 VEGFA
5 steroid hormone mediated signaling pathway GO:0043401 9.49 AR PPARD
6 positive regulation of cell division GO:0051781 9.48 CAT VEGFA
7 intracellular receptor signaling pathway GO:0030522 9.46 AR PPARD
8 response to activity GO:0014823 9.43 CAT PPARD
9 positive regulation of blood vessel diameter GO:0097755 9.37 NOS2 PPARD
10 response to vitamin A GO:0033189 9.16 CAT PPARD
11 mammary gland alveolus development GO:0060749 8.96 AR VEGFA
12 kidney development GO:0001822 8.8 CAT SERPINF1 VEGFA

Molecular functions related to Diabetic Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.16 AR PPARD
2 nuclear receptor activity GO:0004879 8.96 AR PPARD
3 NADP binding GO:0050661 8.62 CAT NOS2

Sources for Diabetic Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....