MCID: DBT007
MIFTS: 42

Diabetic Cataract malady

Eye diseases category

Summaries for Diabetic Cataract

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MalaCards: Diabetic Cataract, also known as cataract - diabetic, is related to cataract and senile cataract. An important gene associated with Diabetic Cataract is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are superoxide radicals degradation and acetone degradation I (to methylglyoxal). The compounds uric acid and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related mouse phenotype vision/eye.

Aliases & Classifications for Diabetic Cataract

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

diabetic cataract 8 10 44 60
cataract - diabetic 8


External Ids:

Disease Ontology8 DOID:13328
ICD9CM27 366.41
ICD1025 H28.0

Related Diseases for Diabetic Cataract

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1cataract31.3GSR, SERPINF1, MIP, AKR1B1, CRYGS, G6PD
2senile cataract30.3GSR, SERPINF1, MIP, CRYGS, G6PD, SOD1
3neuropathy30.1AKR1B1
4diabetic retinopathy30.1SOD1, SORD, AKR1B1, SERPINF1
5glaucoma29.9AKR1B1, MIP, SERPINF1
6obesity29.9MIP, AKR1B1, PPARD
7diabetes mellitus29.8CAT, SOD1, SORD, G6PD, PPARD, AKR1B1
8diabetic neuropathy10.1
9iron deficiency anemia10.0G6PD
10viral hepatitis10.0G6PD
11alpha thalassemia10.0G6PD
12goiter10.0CAT
13duodenal ulcer10.0GSR
14diabetic polyneuropathy10.0AKR1B1
15hepatoblastoma10.0CAT
16gastric ulcer10.0GSR
17meningitis10.0CAT
18pneumonia10.0MIP
19galactosemia10.0CAT
20friedreich ataxia10.0GSR
21favism10.0G6PD
22ovarian cancer10.0SERPINF1
23uveitis10.0SERPINF1
24methemoglobinemia10.0GSR, G6PD
25vascular disease10.0CAT, GSR
26encephalitis10.0CAT
27acute myocardial infarction10.0GSR, CAT
28blindness10.0SERPINF1, AKR1B1
29eales disease10.0SOD1
30glucosephosphate dehydrogenase deficiency10.0GSR, G6PD
31aceruloplasminemia10.0CP
32hyperhomocysteinemia10.0SOD1
33down syndrome10.0SOD1
34pancreatitis10.0SOD1
35proliferative diabetic retinopathy10.0SERPINF1
36osteoarthritis10.0G6PD, GSR
37psoriasis10.0PPARD
38acute pancreatitis10.0SOD1
39hypermethioninemia10.0SOD1
40wilms tumor10.0SERPINF1
41microcytic anemia10.0G6PD
42retinal vascular disease10.0SERPINF1, AKR1B1
43hemosiderosis10.0CP
44prion disease10.0CP, CAT
45adenocarcinoma10.0SERPINF1
46bronchopulmonary dysplasia10.0SOD1
47coronary heart disease10.0PPARD, GSR
48asthma10.0GSR, CP
49amyotrophic lateral sclerosis10.0GSR, SOD1
50hepatitis c10.0GSR

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to diabetic cataract

Clinical Features for Diabetic Cataract

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Drugs & Therapeutics for Diabetic Cataract

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Cataract

Drug clinical trials:

Search ClinicalTrials for Diabetic Cataract

Search NIH Clinical Center for Diabetic Cataract

Search CenterWatch for Diabetic Cataract

Genetic Tests for Diabetic Cataract

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Anatomical Context for Diabetic Cataract

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32MalaCards
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MalaCards organs/tissues related to Diabetic Cataract:

32
Eye, Endothelial

Animal Models for Diabetic Cataract or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.2GSR, CP, SERPINF1, MIP, AKR1B1, CRYGS

Publications for Diabetic Cataract

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50PubMed
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Articles related to Diabetic Cataract:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Effect of combined cataract surgery and ranibizumab injection in postoperative macular edema in nonproliferative diabetic retinopathy. (23807186)
2014
2
Anterior capsular phimosis occluding the capsulorhexis opening after cataract surgery in a diabetic patient with high hemoglobin A1C. (23448558)
2013
3
Macular edema after cataract surgery in eyes without preoperative central-involved diabetic macular edema. (23599174)
2013
4
Prophylactic postoperative ketorolac improves outcomes in diabetic patients assigned for cataract surgery. (23836953)
2013
5
Inhibition of protein glycation by procyanidin-B2 enriched fraction of cinnamon: delay of diabetic cataract in rats. (24136906)
2013
6
Early postoperative intraocular pressure stability after combined 23-gauge sutureless vitrectomy and cataract surgery in patients with proliferative diabetic retinopathy. (22481480)
2012
7
Role of Mediterranean diet, tropical vegetables rich in antioxidants, and sunlight exposureA in blindness, cataract and glaucoma among African type 2 diabetics. (22762057)
2012
8
Expression of PCNA, ICAM-1, and vimentin in lens epithelial cells of cataract patients with and without type 2 diabetes. (22763828)
2012
9
Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy. (22927737)
2012
10
Ranibizumab in patients with dense cataract and proliferative diabetic retinopathy with rubeosis. (23439790)
2012
11
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses. (22683333)
2012
12
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. (21753902)
2011
13
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. (20806076)
2010
14
Prevention of vision loss after cataract surgery in diabetic macular edema with intravitreal bevacizumab: a pilot study. (20827155)
2010
15
Single-nucleotide polymorphisms in chromosome 3p14.1- 3p14.2 are associated with susceptibility of type 2 diabetes with cataract. (20664687)
2010
16
Prevention of vision loss after cataract surgery in diabetic macular edema with intravitreal bevacizumab: a pilot study. (19357559)
2009
17
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. (19898641)
2009
18
Aqueous vascular endothelial growth factor as a predictor of macular thickening following cataract surgery in patients with diabetes mellitus. (19837384)
2009
19
Potential use of hirudin in diabetic cataract: a study of galactose mediated human lens epithelial cells injury. (18400216)
2008
20
Comparison of corneal edema caused by cataract surgery with different phaco times in diabetic and non-diabetic patients. (17200587)
2006
21
Diabetic cataract removal: postoperative progression of maculopathy--growth factor and clinical analysis. (16540489)
2006
22
Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. (15682043)
2005
23
Spontaneous resorption of a diabetic cataract in a geriatric dog. (16119062)
2005
24
Pharmacological prevention of diabetic cataract. (15120709)
2004
25
Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies. (12630936)
2003
26
Blood and lens lipid peroxidation and antioxidant status in normal individuals, senile and diabetic cataractous patients. (12518238)
2002
27
Diabetic cataract of the musk shrew (Suncus murinus, Insectivora) exhibiting spontaneous non-insulin dependent diabetes mellitus (NIDDM). (11769547)
2001
28
Effect of diabetic retinopathy on redox state of aqueous humor and serum albumin in patients with senile cataract. (11885755)
2001
29
Contributions of polyol pathway to oxidative stress in diabetic cataract. (9872926)
1999
30
Localised fibre cell swelling characteristic of diabetic cataract can be induced in normal rat lens using the chloride channel blocker 5-nitro-2-(3-phenylpropylamino) benzoic acid. (10325548)
1999
31
Lens lipid peroxides and glutathione concentrations in diabetic cataract. (9133255)
1997
32
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract. (9323307)
1997
33
Lens lipid peroxides in diabetic cataract. (9367014)
1997
34
Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. (8595250)
1995
35
Human diabetic cataract: role of lipid peroxidation. (7556808)
1995
36
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat. (1898618)
1991
37
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract. (1834606)
1991
38
Topical sulindac therapy in diabetic senile cataracts: cataract-IV. (2632448)
1989
39
Raman spectroscopic study of the effect of aldose reductase inhibitor on experimental diabetic cataract. (3133929)
1988
40
Accumulation of glycation products in alpha-H pig lens crystallin and its bearing to diabetic cataract genesis. (3218484)
1988
41
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. (3917257)
1985
42
Neovascular glaucoma after intracapsular and extracapsular cataract extraction in diabetic patients. (2414993)
1985
43
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. (6226909)
1983
44
Sorbinil protection of lens protein components and cell hydration during diabetic cataract formation. (6803262)
1982
45
The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. (7444756)
1980
46
Model reproduction of diabetic cataract in vitro. (5786891)
1969
47
Biochemistry of the diabetic cataract. (5266937)
1969
48
Further investigations on the reactivity of the P-SH groups: relationship between senile cataract and diabetes. (5398637)
1969
49
Diabetic cataract. (20265649)
1947
50
True Diabetic Cataract. (19987219)
1929

Genetic Variations for Diabetic Cataract

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Expression for genes affiliated with Diabetic Cataract

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for genes affiliated with Diabetic Cataract

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37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 29KEGG
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Pathways related to Diabetic Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CAT, SOD1
2
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9.8AKR1B1, AKR1B10
39.7CAT, SOD1, GSR
49.7GSR, SOD1, CAT
59.7GSR, SOD1, CAT
6
Hide members
9.7AKR1B1, SORD
79.1AKR1B1, AKR1B10, SORD

Compounds for genes affiliated with Diabetic Cataract

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Diabetic Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.7G6PD
2alpha tocopherol4410.7G6PD
3fenton4410.6CP
4glutathion4410.6GSR
5nadph44 2411.5G6PD
6gssg4410.5GSR, G6PD
7diphenyleneiodonium4410.2SOD1, SERPINF1
8ionol4410.2SOD1, CAT, GSR
9randox4410.1CP, GSR, SOD1
10propyl gallate4410.1CAT, SOD1, GSR
11dmpo-oh4410.1CP, SOD1, CAT
12guaiacol44 2411.0CAT, SOD1, GSR
13dmpo4410.0CP, SOD1, CAT
143-amino-1,2,4-triazole4410.0CAT, SOD1, GSR
15tolrestat44 1111.0AKR1B10, AKR1B1, GSR
16d penicillamine449.9GSR, CAT, CP
17sodium azide449.9CAT, SOD1, CP, G6PD
18gsno449.9CAT, SOD1, AKR1B1, GSR
19mannitol44 1110.9SORD, CAT, AKR1B1
20silymarin449.9SOD1, AKR1B1, CAT, GSR
21azide449.9CAT, CP, SOD1
22s-nitroso-n-acetylpenicillamine449.8CP, CAT, SOD1, AKR1B1
23benzyl alcohol44 1110.8AKR1B1, SOD1, CAT
24hypoxanthine44 11 2411.8CAT, SOD1, CP, G6PD
25alpha lipoic acid449.8CAT, G6PD, SOD1, GSR, AKR1B1
264-hydroxynonenal44 2410.8G6PD, CAT, GSR, AKR1B1, SOD1
27ebselen449.7CAT, SOD1, GSR
28thiobarbituric acid449.7G6PD, GSR, CAT, SOD1, CP
29dehydroascorbic acid44 1110.7CAT, CP, G6PD, GSR, SOD1
30tocopherol449.7CP, CAT, SOD1, G6PD, GSR
31selenium44 2410.7GSR, SOD1, CP, CAT
32malondialdehyde449.7GSR, CAT, G6PD, CP, SOD1
33betacarotene449.7GSR, SOD1, CAT, CP
34dtpa449.7CP, SOD1, CAT
35vitamin-e449.7G6PD, CAT, GSR, CP, SOD1
36nadp+449.6GSR, AKR1B1, SORD, G6PD
37menadione44 11 2411.6GSR, CAT, SOD1, KEAP1
38oxygen44 2410.5SERPINF1, MIP, AKR1B1, KEAP1, PPARD
39glucose 6-phosphate44 2410.5SORD, G6PD, CAT, SOD1
40n acetylcysteine449.5CAT, AKR1B1, GSR, G6PD, SOD1, SERPINF1
41sodium arsenite449.5GSR, CAT, SOD1, SORD
42ascorbic acid44 2410.5G6PD, SOD1, AKR1B1, CP, GSR, CAT
43levodopa44 1110.4CP, AKR1B1, SOD1, CAT
44indomethacin44 59 28 1112.3PPARD, GSR, CP, CAT, AKR1B1, SOD1
45nadh44 11 2411.1CAT, SORD, G6PD, GSR, AKR1B1, SOD1
46superoxide44 249.8SOD1, CAT, SORD, G6PD, CP, GSR
47lactate448.7CP, SORD, MIP, AKR1B1, G6PD, SOD1
48h2o2448.7MIP, CP, GSR, SOD1, AKR1B1, KEAP1
49creatinine448.4CP, AKR1B1, G6PD, SORD, GSR, SOD1
50cysteine448.4VARS, SERPINF1, CP, GSR, MIP, KEAP1

GO Terms for genes affiliated with Diabetic Cataract

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16Gene Ontology
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Biological processes related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1doxorubicin metabolic processGO:0445989.8AKR1B1, AKR1B10
2glutathione metabolic processGO:0067499.7GSR, G6PD, SOD1
3daunorubicin metabolic processGO:0445979.5AKR1B1, AKR1B10

Molecular functions related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aldo-keto reductase (NADP) activityGO:0040339.8AKR1B1, AKR1B10
2NADP bindingGO:0506619.5GSR, G6PD, CAT

Products for genes affiliated with Diabetic Cataract

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Sources for Diabetic Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet