MCID: DBT007
MIFTS: 42

Diabetic Cataract malady

Eye diseases category
Download this MalaCard

Summaries for Diabetic Cataract

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Diabetic Cataract, also known as cataract - diabetic, is related to cataract and glaucoma. An important gene associated with Diabetic Cataract is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Sulfation Biotransformation Reaction and Fructose and mannose metabolism. The compounds tert-butylhydroperoxide and ionol have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Aliases & Classifications for Diabetic Cataract

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

diabetic cataract 8 10 45 62
cataract - diabetic 8


External Ids:

Disease Ontology8 DOID:13328
ICD9CM27 366.41
ICD1025 H28.0

Related Diseases for Diabetic Cataract

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1cataract31.2GSR, SERPINF1, SOD1, AKR1B1, MIP, CAT
2glaucoma30.0MIP, AKR1B1, SERPINF1
3diabetic retinopathy29.9SERPINF1, SOD1, SORD, AKR1B1
4senile cataract29.8SOD1, GSR, CAT, MIP, G6PD, SERPINF1
5diabetes mellitus29.7SORD, G6PD, GSR, CAT, AKR1B1, PPARD
6neuropathy10.1
7favism10.1G6PD
8diabetic macular edema10.1SERPINF1
9eales disease10.1SOD1
10methemoglobinemia10.1G6PD, GSR
11hypermethioninemia10.1SOD1
12glucosephosphate dehydrogenase deficiency10.1GSR, G6PD
13beta thalassemia10.1G6PD, GSR
14retinal vascular disease10.1AKR1B1, SERPINF1
15plasmodium falciparum malaria10.1G6PD, GSR
16respiratory failure10.1CAT, G6PD
17pneumoconiosis10.1CAT, SOD1
18brain edema10.0SOD1, MIP
19acute kidney failure10.0CAT, G6PD
20alcoholic liver cirrhosis10.0SOD1, CAT
21primary hyperoxaluria10.0G6PD, GSR, MIP
22diabetic nephropathy10.0AKR1B1, SERPINF1, CAT
23wilson disease10.0CAT, G6PD, SOD1
24cataract, congenital10.0SORD, MIP
25chronic granulomatous disease10.0CAT, G6PD, SOD1
26malaria10.0MIP, G6PD, GSR
27metabolic syndrome x10.0G6PD, AKR1B1, PPARD
28congenital heart disease10.0GSR, G6PD, MIP
29cerebrovascular disease10.0AKR1B1, MIP, GSR
30lymphopenia10.0CAT, GSR
31male infertility10.0SOD1, CAT
32vitiligo10.0SOD1, G6PD, CAT, GSR
33chronic kidney failure10.0CAT, SOD1, AKR1B1, GSR
34myocardial infarction10.0GSR, PPARD, AKR1B1
35type 2 diabetes mellitus10.0SOD1, GSR, CAT, AKR1B1
36parkinson's disease10.0GSR, CAT, SOD1, SERPINF1
37vascular disease10.0GSR, AKR1B1, G6PD, SOD1, CAT
38malignant glioma10.0GSR, G6PD, SERPINF1, CAT, MIP
39obesity10.0
40open-angle glaucoma10.0
41retinitis10.0
42turner syndrome10.0
43premature aging okamoto type10.0
44ischemia10.0SOD1, MIP, CAT, GSR, AKR1B1
45melanoma10.0CAT, AKR1B1, SERPINF1, PPARD
46alzheimer's disease9.9GSR, PPARD, SERPINF1, SOD1, CAT
47hyperglycemia9.9CAT, AKR1B1, SORD, SOD1, SERPINF1
48atherosclerosis9.9SOD1, G6PD, AKR1B1, CAT, PPARD, SERPINF1

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to diabetic cataract

Symptoms for Diabetic Cataract

About this section

Drugs & Therapeutics for Diabetic Cataract

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Diabetic Cataract

Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

About this section

Anatomical Context for Diabetic Cataract

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Diabetic Cataract:

33
Eye

Animal Models for Diabetic Cataract or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Diabetic Cataract:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.7GSR, MIP, AKR1B1, SORD, SOD1, SERPINF1
2MP:00053767.6SOD1, SORD, G6PD, AKR1B1, CAT, KEAP1

Publications for Diabetic Cataract

About this section
Sources:
52PubMed
See all sources

Articles related to Diabetic Cataract:

(show top 50)    (show all 87)
idTitleAuthorsYear
1
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. (23137000)
2013
2
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. (23671855)
2013
3
Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract. (23827758)
2013
4
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. (22407349)
2012
5
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. (23365598)
2012
6
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. (22687477)
2012
7
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. (21271438)
2011
8
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. (20806076)
2010
9
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. (19898641)
2009
10
Delay of diabetic cataract in rats by the antiglycating potential of cumin through modulation of alpha-crystallin chaperone activity. (18789666)
2009
11
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. (18490958)
2008
12
Potential use of hirudin in diabetic cataract: a study of galactose mediated human lens epithelial cells injury. (18400216)
2008
13
Efficacy of alpha-lipoic acid against diabetic cataract in rat. (17295134)
2007
14
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. (17240813)
2006
15
Correlation between adult diabetic cataracts and red blood cell aldose reductase levels. (16639016)
2006
16
Acute irreversible diabetic cataract in adolescence: a case report. (15877100)
2006
17
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress. (16797533)
2006
18
Antioxidant markers in human senile and diabetic cataractous lenses. (17007750)
2006
19
Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. (15682043)
2005
20
Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. (15914628)
2005
21
Morphogenetic and apoptotic changes in diabetic cataract: prevention by pyruvate. (15532728)
2004
22
Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract. (12882795)
2003
23
Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies. (12630936)
2003
24
Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. (12458487)
2002
25
Blood and lens lipid peroxidation and antioxidant status in normal individuals, senile and diabetic cataractous patients. (12518238)
2002
26
Contributions of polyol pathway to oxidative stress in diabetic cataract. (9872926)
1999
27
Acceleration of development of diabetic cataract by hyperlipidemia and low high-density lipoprotein in rats. (9989659)
1999
28
Type I diabetic cataract. (10037586)
1999
29
Diabetic cataract in children. (9591961)
1998
30
Lens lipid peroxides and glutathione concentrations in diabetic cataract. (9133255)
1997
31
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract. (9323307)
1997
32
The diabetic cataract: an unusual presentation in a young subject: case report. (9201605)
1997
33
Modelling cortical cataractogenesis. 13. Early effects on lens ATP/ADP and glutathione in the streptozotocin rat model of the diabetic cataract. (8462652)
1993
34
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1628701)
1992
35
Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance]. (1908617)
1991
36
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat. (1898618)
1991
37
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1821625)
1991
38
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract. (1834606)
1991
39
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. (3917257)
1985
40
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. (6226909)
1983
41
Studies on diabetic cataract in rats induced by streptozotocin. I. Photodocumentation of lens opacification. (6226908)
1983
42
Sorbinil protection of lens protein components and cell hydration during diabetic cataract formation. (6803262)
1982
43
Diabetic cataract formation: potential role of glycosylation of lens crystallins. (275862)
1978
44
Biochemistry of the diabetic cataract. (5266937)
1969
45
DIABETIC CATARACT. (14211991)
1963
46
Metabolic pathways in experimental diabetic cataract. (14464237)
1962
47
Effect of partial starvation on development of diabetic cataract. (13237254)
1954
48
Diabetic cataract. (20265649)
1947
49
(a) Diabetic Cataract; (b) Endocrine Cataract. (19993468)
1947
50
True Diabetic Cataract. (19987219)
1929

Variations for Diabetic Cataract

About this section

Expression for genes affiliated with Diabetic Cataract

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for genes affiliated with Diabetic Cataract

About this section
Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 51PharmGKB
See all sources

Pathways related to Diabetic Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GSR, G6PD
2
Show member pathways
Polyol pathway38
GDP-L-fucose biosynthesis II (from L-fucose)38
sorbitol degradation I38
9.7AKR1B1, SORD
3
Show member pathways
Vitamin B12 Metabolism38
9.5CAT, SOD1
49.5CAT, SOD1
5
Show member pathways
9.5CAT, SOD1
6
Show member pathways
9.2SOD1, CAT, GSR
7
Show member pathways
9.2SOD1, CAT, GSR
8
Show member pathways
thioredoxin pathway38
9.2GSR, CAT, SOD1
99.2CAT, SOD1, GSR

Compounds for genes affiliated with Diabetic Cataract

About this section
Sources:
45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Diabetic Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1tert-butylhydroperoxide459.8GSR, CAT, G6PD
2ionol459.6GSR, CAT, SOD1
3propyl gallate459.6CAT, SOD1, GSR
4guaiacol45 2410.6GSR, CAT, SOD1
5glutathion459.6SOD1, GSR, CAT
63-amino-1,2,4-triazole459.6GSR, SOD1, CAT
7sodium azide459.6CAT, SOD1, G6PD
8benzyl alcohol45 1110.6AKR1B1, CAT, SOD1
9fenton459.6GSR, SOD1, CAT
10probucol45 1110.5CAT, AKR1B1, SOD1
11ebselen459.5GSR, SOD1, CAT
12bathocuproine459.5SOD1, CAT
13nadp+459.5SORD, G6PD, AKR1B1, GSR
14selenite459.5GSR, CAT, SOD1
15tetrahydrobiopterin45 24 1111.5SOD1, AKR1B1, CAT
16NADP249.5G6PD, GSR, CAT, AKR1B1
17ubiquinone459.4CAT, GSR, SOD1
18thiobarbituric acid459.4SOD1, G6PD, CAT, GSR
19dehydroascorbic acid45 1110.4SOD1, G6PD, GSR, CAT
20gsno459.4GSR, AKR1B1, CAT, SOD1
21tocopherol459.4G6PD, CAT, SOD1, GSR
22gssg459.4GSR, CAT, G6PD, SOD1
23silymarin459.4AKR1B1, GSR, SOD1, CAT
24tbhq459.3CAT, GSR, KEAP1
25malondialdehyde459.3SOD1, G6PD, CAT, GSR
26uric acid45 2410.3SOD1, G6PD, CAT, GSR
27vitamin-e459.3SOD1, GSR, CAT, G6PD
28diphenyleneiodonium459.3CAT, G6PD, SOD1, SERPINF1
29trientine459.3SOD1, GSR
30alpha tocopherol459.2SOD1, CAT, G6PD, GSR
31quercetin45 61 24 1112.2GSR, CAT, AKR1B1, SOD1
32menadione45 24 1111.2CAT, SOD1, GSR, KEAP1
33alpha lipoic acid459.1GSR, SOD1, CAT, AKR1B1, G6PD
34sodium arsenite459.1GSR, SOD1, SORD, CAT
354-hydroxynonenal45 2410.1G6PD, CAT, GSR, SOD1, AKR1B1
36ascorbic acid45 2410.0G6PD, CAT, AKR1B1, GSR, SOD1
37arsenite45 2410.0MIP, SOD1, GSR, CAT
38glucose 6-phosphate45 249.9CAT, SOD1, SORD, GSR, G6PD
39indomethacin45 29 61 1111.9PPARD, GSR, CAT, AKR1B1, SOD1
40n acetylcysteine458.7SOD1, GSR, G6PD, AKR1B1, CAT, SERPINF1
41nadph45 249.7SERPINF1, GSR, CAT, AKR1B1, G6PD, SOD1
42superoxide45 249.6SOD1, SORD, G6PD, CAT, GSR
43creatinine458.6AKR1B1, SOD1, SORD, GSR, G6PD
44nadh45 24 1110.6GSR, SOD1, AKR1B1, CAT, G6PD, SORD
45mannitol45 119.6SOD1, SORD, G6PD, AKR1B1, MIP, CAT
46lactate458.3SOD1, GSR, MIP, CAT, SORD, AKR1B1
47glucose458.2SERPINF1, MIP, AKR1B1, G6PD, SORD, PPARD
48cysteine458.2CAT, GSR, SERPINF1, AKR1B1, MIP, SOD1
49h2o2458.0AKR1B1, GSR, KEAP1, SERPINF1, G6PD, CAT
50oxygen45 248.5MIP, KEAP1, GSR, CAT, AKR1B1, G6PD

GO Terms for genes affiliated with Diabetic Cataract

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.1GSR, AKR1B1, G6PD, SORD, SOD1, SERPINF1

Biological processes related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.7CAT, PPARD
2glutathione metabolic processGO:0067499.2GSR, G6PD, SOD1
3embryo implantationGO:0075669.1SOD1, PPARD

Molecular functions related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.6GSR, CAT, G6PD

Products for genes affiliated with Diabetic Cataract

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetic Cataract

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet