MCID: DBT007
MIFTS: 42

Diabetic Cataract malady

Eye diseases category

Summaries for Diabetic Cataract

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MalaCards: Diabetic Cataract, also known as cataract - diabetic, is related to cataract and senile cataract. An important gene associated with Diabetic Cataract is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are superoxide radicals degradation and acetone degradation I (to methylglyoxal). The compounds uric acid and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related mouse phenotype vision/eye.

Aliases & Classifications for Diabetic Cataract

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

diabetic cataract 8 10 44 60
cataract - diabetic 8


External Ids:

Disease Ontology8 DOID:13328
ICD9CM27 366.41
ICD1025 H28.0

Related Diseases for Diabetic Cataract

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1cataract31.3GSR, SERPINF1, MIP, AKR1B1, CRYGS, G6PD
2senile cataract30.3GSR, SERPINF1, MIP, CRYGS, G6PD, SOD1
3neuropathy30.1AKR1B1
4diabetic retinopathy30.1SOD1, SORD, AKR1B1, SERPINF1
5glaucoma29.9AKR1B1, MIP, SERPINF1
6obesity29.9MIP, AKR1B1, PPARD
7diabetes mellitus29.8CAT, SOD1, SORD, G6PD, PPARD, AKR1B1
8diabetic neuropathy10.1
9iron deficiency anemia10.0G6PD
10viral hepatitis10.0G6PD
11alpha thalassemia10.0G6PD
12goiter10.0CAT
13duodenal ulcer10.0GSR
14diabetic polyneuropathy10.0AKR1B1
15hepatoblastoma10.0CAT
16gastric ulcer10.0GSR
17meningitis10.0CAT
18pneumonia10.0MIP
19galactosemia10.0CAT
20friedreich ataxia10.0GSR
21favism10.0G6PD
22ovarian cancer10.0SERPINF1
23uveitis10.0SERPINF1
24methemoglobinemia10.0GSR, G6PD
25vascular disease10.0CAT, GSR
26encephalitis10.0CAT
27acute myocardial infarction10.0GSR, CAT
28blindness10.0SERPINF1, AKR1B1
29eales disease10.0SOD1
30glucosephosphate dehydrogenase deficiency10.0GSR, G6PD
31aceruloplasminemia10.0CP
32hyperhomocysteinemia10.0SOD1
33down syndrome10.0SOD1
34pancreatitis10.0SOD1
35proliferative diabetic retinopathy10.0SERPINF1
36osteoarthritis10.0G6PD, GSR
37psoriasis10.0PPARD
38acute pancreatitis10.0SOD1
39hypermethioninemia10.0SOD1
40wilms tumor10.0SERPINF1
41microcytic anemia10.0G6PD
42retinal vascular disease10.0SERPINF1, AKR1B1
43hemosiderosis10.0CP
44prion disease10.0CP, CAT
45adenocarcinoma10.0SERPINF1
46bronchopulmonary dysplasia10.0SOD1
47coronary heart disease10.0PPARD, GSR
48asthma10.0GSR, CP
49amyotrophic lateral sclerosis10.0GSR, SOD1
50hepatitis c10.0GSR

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to diabetic cataract

Clinical Features for Diabetic Cataract

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Drugs & Therapeutics for Diabetic Cataract

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Cataract

Drug clinical trials:

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Search NIH Clinical Center for Diabetic Cataract

Search CenterWatch for Diabetic Cataract

Genetic Tests for Diabetic Cataract

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Anatomical Context for Diabetic Cataract

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32MalaCards
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MalaCards organs/tissues related to Diabetic Cataract:

32
Eye, Endothelial

Animal Models for Diabetic Cataract or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.2GSR, CP, SERPINF1, MIP, AKR1B1, CRYGS

Publications for Diabetic Cataract

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50PubMed
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Articles related to Diabetic Cataract:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Pilot Study of Individuals With Diabetic Macular Edema Undergoing Cataract Surgery. (24309926)
2013
2
Cataract in children and adolescents with fibrocalculous pancreatic diabetes. (23715357)
2013
3
Bilateral cataracts and insulin oedema in a child with type 1 diabetes mellitus. (23378550)
2013
4
Anterior capsule contraction and flare intensity in the early stages after cataract surgery in eyes with diabetic retinopathy. (23541898)
2013
5
Early phacoemulsification in diabetic cataract for early recognition and management of diabetic macular oedema. (23763799)
2013
6
Incidence of visual impairment due to cataract, diabetic retinopathy and trachoma in indigenous Australians within central Australia: the Central Australian Ocular Health Study. (22594763)
2013
7
Long-term results, prognostic factors and cataract surgery after diabetic vitrectomy: a 10-year follow-up study. (24373516)
2013
8
Additive effect of aldose reductase z-4 microsatellite polymorphism and glycemic control on cataract development in type 2 diabetes. (24332938)
2013
9
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. (23365598)
2012
10
To assess the levels of zinc in serum and changes in the lens of diabetic and senile cataract patients. (22360021)
2011
11
Diabetic cataract-pathogenesis, epidemiology and treatment. (20634936)
2010
12
The evaluation of the oxidative stress parameters in nondiabetic and diabetic senile cataract patients. (18982249)
2009
13
The combination of intravitreal bevacizumab and phacoemulsification surgery in patients with cataract and coexisting diabetic macular edema. (19232012)
2009
14
Malformation of junctional microdomains in cataract lens membranes from a type II diabetes patient. (19034495)
2009
15
Influence of selected angiotensin-converting enzyme inhibitors on alloxan-induced diabetic cataract in rabbits. (19865050)
2009
16
Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats. (19098320)
2009
17
Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus. (19093039)
2008
18
Long-term treatment with ranirestat (AS-3201), a potent aldose reductase inhibitor, suppresses diabetic neuropathy and cataract formation in rats. (18612195)
2008
19
Changes in erythrocyte glucose-6-phosphate dehydrogenase (G6PD) and reduced glutathione (GSH) activities in the development of senile and diabetic cataracts. (19058613)
2008
20
Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract. (17466963)
2007
21
Efficacy of alpha-lipoic acid against diabetic cataract in rat. (17295134)
2007
22
Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. (17679931)
2007
23
Prevention of cataract by pyruvate in experimentally diabetic mice. (15786723)
2005
24
Cataracts in experimentally diabetic mouse: morphological and apoptotic changes. (15715894)
2005
25
Electrophoretic analysis of oxidatively modified eye lens proteins in vitro: implications for diabetic cataract. (16114241)
2005
26
Morphogenetic and apoptotic changes in diabetic cataract: prevention by pyruvate. (15532728)
2004
27
Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract. (12882795)
2003
28
Pars plana lensectomy, pars plana vitrectomy, and silicone oil tamponade as initial management of cataract and combined traction/rhegmatogenous retinal detachment involving the macula associated with severe proliferative diabetic retinopathy. (12875454)
2003
29
Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235. (12140204)
2002
30
Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. (12458487)
2002
31
Effect of high-glucose levels on protein oxidation in cultured lens cells, and in crystalline and albumin solution and its inhibition by vitamin B6 and N-acetylcysteine: its possible relevance to cataract formation in diabetes. (12488130)
2002
32
A study of factors related to the incidence of cataract in patients with non-insulin dependent diabetes mellitus. (12567748)
2001
33
Type I diabetic cataract. (10037586)
1999
34
Diabetic cataract in children. (9591961)
1998
35
The diabetic cataract: an unusual presentation in a young subject: case report. (9201605)
1997
36
A technical approach to the evaluation of glucose oxidation: implications for diabetic cataract. (8979275)
1996
37
Metabolic control of non-insulin-dependent diabetic patients undergoing cataract surgery: comparison of local and general anaesthesia. (7772420)
1995
38
In vivo assessment of an animal model of diabetic cataract: medical intervention studies. (7895883)
1994
39
Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation. (8336207)
1993
40
Modelling cortical cataractogenesis. 13. Early effects on lens ATP/ADP and glutathione in the streptozotocin rat model of the diabetic cataract. (8462652)
1993
41
RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains. (8104833)
1993
42
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1821625)
1991
43
Neutrophil aldose reductase activity as a potential marker for neuropathy and cataract in diabetes. (1838041)
1991
44
2-D electrophoresis distribution of stable 14C-glycation products from pig lens crystallins in relation to diabetic cataract formation. (2721373)
1989
45
Studies on diabetic cataract in rats induced by streptozotocin. I. Photodocumentation of lens opacification. (6226908)
1983
46
Diabetic cataract formation: potential role of glycosylation of lens crystallins. (275862)
1978
47
Senile cataract extraction and diabetes. (1276117)
1976
48
DIABETIC CATARACT. (14211991)
1963
49
Metabolic pathways in experimental diabetic cataract. (14464237)
1962
50
Two Cases of True Diabetic Cataract. (19986092)
1927

Genetic Variations for Diabetic Cataract

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Expression for genes affiliated with Diabetic Cataract

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Cataract

Search GEO for disease gene expression data for Diabetic Cataract.

Pathways for genes affiliated with Diabetic Cataract

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37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 29KEGG
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Pathways related to Diabetic Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CAT, SOD1
2
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9.8AKR1B1, AKR1B10
39.7CAT, SOD1, GSR
49.7GSR, SOD1, CAT
59.7GSR, SOD1, CAT
6
Hide members
9.7AKR1B1, SORD
79.1AKR1B1, AKR1B10, SORD

Compounds for genes affiliated with Diabetic Cataract

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Diabetic Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 128)
idCompoundScoreTop Affiliating Genes
1uric acid44 2411.7G6PD
2alpha tocopherol4410.7G6PD
3fenton4410.6CP
4glutathion4410.6GSR
5nadph44 2411.5G6PD
6gssg4410.5GSR, G6PD
7diphenyleneiodonium4410.2SOD1, SERPINF1
8ionol4410.2SOD1, CAT, GSR
9randox4410.1CP, GSR, SOD1
10propyl gallate4410.1CAT, SOD1, GSR
11dmpo-oh4410.1CP, SOD1, CAT
12guaiacol44 2411.0CAT, SOD1, GSR
13dmpo4410.0CP, SOD1, CAT
143-amino-1,2,4-triazole4410.0CAT, SOD1, GSR
15tolrestat44 1111.0AKR1B10, AKR1B1, GSR
16d penicillamine449.9GSR, CAT, CP
17sodium azide449.9CAT, SOD1, CP, G6PD
18gsno449.9CAT, SOD1, AKR1B1, GSR
19mannitol44 1110.9SORD, CAT, AKR1B1
20silymarin449.9SOD1, AKR1B1, CAT, GSR
21azide449.9CAT, CP, SOD1
22s-nitroso-n-acetylpenicillamine449.8CP, CAT, SOD1, AKR1B1
23benzyl alcohol44 1110.8AKR1B1, SOD1, CAT
24hypoxanthine44 11 2411.8CAT, SOD1, CP, G6PD
25alpha lipoic acid449.8CAT, G6PD, SOD1, GSR, AKR1B1
264-hydroxynonenal44 2410.8G6PD, CAT, GSR, AKR1B1, SOD1
27ebselen449.7CAT, SOD1, GSR
28thiobarbituric acid449.7G6PD, GSR, CAT, SOD1, CP
29dehydroascorbic acid44 1110.7CAT, CP, G6PD, GSR, SOD1
30tocopherol449.7CP, CAT, SOD1, G6PD, GSR
31selenium44 2410.7GSR, SOD1, CP, CAT
32malondialdehyde449.7GSR, CAT, G6PD, CP, SOD1
33betacarotene449.7GSR, SOD1, CAT, CP
34dtpa449.7CP, SOD1, CAT
35vitamin-e449.7G6PD, CAT, GSR, CP, SOD1
36nadp+449.6GSR, AKR1B1, SORD, G6PD
37menadione44 11 2411.6GSR, CAT, SOD1, KEAP1
38oxygen44 2410.5SERPINF1, MIP, AKR1B1, KEAP1, PPARD
39glucose 6-phosphate44 2410.5SORD, G6PD, CAT, SOD1
40n acetylcysteine449.5CAT, AKR1B1, GSR, G6PD, SOD1, SERPINF1
41sodium arsenite449.5GSR, CAT, SOD1, SORD
42ascorbic acid44 2410.5G6PD, SOD1, AKR1B1, CP, GSR, CAT
43levodopa44 1110.4CP, AKR1B1, SOD1, CAT
44indomethacin44 59 28 1112.3PPARD, GSR, CP, CAT, AKR1B1, SOD1
45nadh44 11 2411.1CAT, SORD, G6PD, GSR, AKR1B1, SOD1
46superoxide44 249.8SOD1, CAT, SORD, G6PD, CP, GSR
47lactate448.7CP, SORD, MIP, AKR1B1, G6PD, SOD1
48h2o2448.7MIP, CP, GSR, SOD1, AKR1B1, KEAP1
49creatinine448.4CP, AKR1B1, G6PD, SORD, GSR, SOD1
50cysteine448.4VARS, SERPINF1, CP, GSR, MIP, KEAP1

GO Terms for genes affiliated with Diabetic Cataract

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16Gene Ontology
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Biological processes related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1doxorubicin metabolic processGO:0445989.8AKR1B1, AKR1B10
2glutathione metabolic processGO:0067499.7GSR, G6PD, SOD1
3daunorubicin metabolic processGO:0445979.5AKR1B1, AKR1B10

Molecular functions related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1aldo-keto reductase (NADP) activityGO:0040339.8AKR1B1, AKR1B10
2NADP bindingGO:0506619.5GSR, G6PD, CAT

Products for genes affiliated with Diabetic Cataract

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Sources for Diabetic Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet