MCID: DBT007
MIFTS: 43

Diabetic Cataract malady

Eye diseases category
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Summaries for Diabetic Cataract

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MalaCards based summary: Diabetic Cataract, also known as cataract - diabetic, is related to cataract and diabetic retinopathy. An important gene associated with Diabetic Cataract is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Sulfation Biotransformation Reaction and Fructose and mannose metabolism. The compounds tert-butylhydroperoxide and ionol have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Aliases & Classifications for Diabetic Cataract

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Diabetic Cataract, Aliases & Descriptions:

Name: Diabetic Cataract 8 10 44 62
 
Cataract - Diabetic 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:13328
ICD9CM27 366.41
ICD1025 H28.0

Related Diseases for Diabetic Cataract

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Diseases related to Diabetic Cataract via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1cataract30.4SORD, SOD1, SERPINF1, G6PD, AKR1B1, GSR
2diabetic retinopathy30.0AKR1B1, SORD, SOD1, SERPINF1
3hyperglycemia29.5SERPINF1, SOD1, SORD, AKR1B1, CAT
4senile cataract29.5GSR, CAT, MIP, G6PD, SOD1, SERPINF1
5diabetes mellitus29.1PPARD, SOD1, SORD, G6PD, AKR1B1, CAT
6favism10.5G6PD
7diabetic macular edema10.4SERPINF1
8methemoglobinemia10.4GSR, G6PD
9eales disease10.4SOD1
10hypermethioninemia10.4SOD1
11glucosephosphate dehydrogenase deficiency10.4G6PD, GSR
12beta thalassemia10.3G6PD, GSR
13retinal vascular disease10.3SERPINF1, AKR1B1
14plasmodium falciparum malaria10.3G6PD, GSR
15respiratory failure10.3CAT, G6PD
16pneumoconiosis10.3SOD1, CAT
17brain edema10.2MIP, SOD1
18alcoholic liver cirrhosis10.2CAT, SOD1
19primary hyperoxaluria10.2GSR, MIP, G6PD
20diabetic nephropathy10.2CAT, AKR1B1, SERPINF1
21acute kidney failure10.2CAT, G6PD
22cataract, congenital10.1SORD, MIP
23wilson disease10.1CAT, G6PD, SOD1
24chronic granulomatous disease10.1CAT, G6PD, SOD1
25malaria10.1GSR, MIP, G6PD
26neuropathy10.1
27metabolic syndrome x10.1PPARD, G6PD, AKR1B1
28congenital heart disease10.1G6PD, MIP, GSR
29cerebrovascular disease10.1GSR, MIP, AKR1B1
30male infertility10.1CAT, SOD1
31lymphopenia10.1CAT, GSR
32vitiligo10.0GSR, CAT, G6PD, SOD1
33myocardial infarction10.0GSR, AKR1B1, PPARD
34chronic kidney failure10.0SOD1, AKR1B1, CAT, GSR
35type 2 diabetes mellitus10.0GSR, CAT, AKR1B1, SOD1
36obesity10.0
37trachoma10.0
38open-angle glaucoma10.0
39retinitis10.0
40turner syndrome10.0
41premature aging okamoto type10.0
42parkinson's disease10.0SERPINF1, SOD1, CAT, GSR
43vascular disease9.9SOD1, G6PD, AKR1B1, CAT, GSR
44malignant glioma9.9SERPINF1, G6PD, MIP, CAT, GSR
45ischemia9.9SOD1, AKR1B1, MIP, CAT, GSR
46melanoma9.8CAT, AKR1B1, SERPINF1, PPARD
47alzheimer's disease9.7PPARD, SERPINF1, SOD1, CAT, GSR
48atherosclerosis9.6PPARD, SERPINF1, SOD1, G6PD, AKR1B1, CAT

Graphical network of the top 20 diseases related to Diabetic Cataract:



Diseases related to diabetic cataract

Symptoms for Diabetic Cataract

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Drugs & Therapeutics for Diabetic Cataract

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Drug clinical trials:

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Search NIH Clinical Center for Diabetic Cataract

Genetic Tests for Diabetic Cataract

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Anatomical Context for Diabetic Cataract

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MalaCards organs/tissues related to Diabetic Cataract:

32
Eye

Animal Models for Diabetic Cataract or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.7GSR, MIP, AKR1B1, SORD, SOD1, SERPINF1
2MP:00053767.6SOD1, SORD, G6PD, AKR1B1, CAT, KEAP1

Publications for Diabetic Cataract

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Articles related to Diabetic Cataract:

(show top 50)    (show all 93)
idTitleAuthorsYear
1
Retraction. Activation of aldose reductase by interaction with tubulin and involvement of this mechanism in diabetic cataract formation. Diabetes. 10 April 2014 [Epub ahead of print]. DOI: 10.2337/db13-1265. (24722247)
2014
2
Inhibition of diabetic-cataract by vitamin K1 involves modulation of hyperglycemia-induced alterations to lens calcium homeostasis. (25257692)
2014
3
Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract. (25314260)
2014
4
Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. (24527449)
2014
5
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. (23137000)
2013
6
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. (23671855)
2013
7
Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. (22407349)
2012
8
Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity. (23365598)
2012
9
GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. (22687477)
2012
10
Topical metal chelation therapy ameliorates oxidation-induced toxicity in diabetic cataract. (21271438)
2011
11
Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats. (20806076)
2010
12
Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats. (19898641)
2009
13
Delay of diabetic cataract in rats by the antiglycating potential of cumin through modulation of alpha-crystallin chaperone activity. (18789666)
2009
14
Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. (18490958)
2008
15
Potential use of hirudin in diabetic cataract: a study of galactose mediated human lens epithelial cells injury. (18400216)
2008
16
Efficacy of alpha-lipoic acid against diabetic cataract in rat. (17295134)
2007
17
Role of anti-oxidant enzymes superoxide dismutase and catalase in the development of cataract : study of serum levels in patients with senile and diabetic cataracts. (17240813)
2006
18
Correlation between adult diabetic cataracts and red blood cell aldose reductase levels. (16639016)
2006
19
Acute irreversible diabetic cataract in adolescence: a case report. (15877100)
2006
20
Synergism between phospholipase D2 and sorbitol accumulation in diabetic cataract formation through modulation of Na,K-ATPase activity and osmotic stress. (16797533)
2006
21
Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT. (15682043)
2005
22
Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract. (12882795)
2003
23
Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies. (12630936)
2003
24
Prevention of experimental diabetic cataract by Indian Ayurvedic plant extracts. (12458487)
2002
25
Blood and lens lipid peroxidation and antioxidant status in normal individuals, senile and diabetic cataractous patients. (12518238)
2002
26
Contributions of polyol pathway to oxidative stress in diabetic cataract. (9872926)
1999
27
Acceleration of development of diabetic cataract by hyperlipidemia and low high-density lipoprotein in rats. (9989659)
1999
28
Type I diabetic cataract. (10037586)
1999
29
Diabetic cataract in children. (9591961)
1998
30
Lens lipid peroxides and glutathione concentrations in diabetic cataract. (9133255)
1997
31
Effect of pyruvate on lens myo-inositol transport and polyol formation in diabetic cataract. (9323307)
1997
32
The diabetic cataract: an unusual presentation in a young subject: case report. (9201605)
1997
33
Modelling cortical cataractogenesis. 13. Early effects on lens ATP/ADP and glutathione in the streptozotocin rat model of the diabetic cataract. (8462652)
1993
34
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1628701)
1992
35
Quantitative study of rat diabetic cataract, by the relaxation times of nuclear magnetic resonance]. (1908617)
1991
36
Characterization of a novel aldose reductase inhibitor, FR74366, and its effects on diabetic cataract and neuropathy in the rat. (1898618)
1991
37
Proteins of urea-soluble high molecular weight (HMW) aggregates from diabetic cataract: identification of in vivo glycation sites. (1821625)
1991
38
Effect of instillation of aldose reductase inhibitor FR74366 on diabetic cataract. (1834606)
1991
39
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor. (3917257)
1985
40
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages. (6226909)
1983
41
Studies on diabetic cataract in rats induced by streptozotocin. I. Photodocumentation of lens opacification. (6226908)
1983
42
Sorbinil protection of lens protein components and cell hydration during diabetic cataract formation. (6803262)
1982
43
Diabetic cataract formation: potential role of glycosylation of lens crystallins. (275862)
1978
44
Model reproduction of diabetic cataract in vitro. (5786891)
1969
45
Biochemistry of the diabetic cataract. (5266937)
1969
46
Metabolic pathways in experimental diabetic cataract. (14464237)
1962
47
Effect of partial starvation on development of diabetic cataract. (13237254)
1954
48
Diabetic cataract. (20265649)
1947
49
(a) Diabetic Cataract; (b) Endocrine Cataract. (19993468)
1947
50
True Diabetic Cataract. (19987219)
1929

Variations for Diabetic Cataract

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Expression for genes affiliated with Diabetic Cataract

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Expression patterns in normal tissues for genes affiliated with Diabetic Cataract

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Pathways for genes affiliated with Diabetic Cataract

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Pathways related to Diabetic Cataract according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9G6PD, GSR
2
Show member pathways
Polyol pathway37
GDP-L-fucose biosynthesis II (from L-fucose)37
sorbitol degradation I37
9.7SORD, AKR1B1
3
Show member pathways
Vitamin B12 Metabolism37
9.5CAT, SOD1
49.5SOD1, CAT
5
Show member pathways
9.5CAT, SOD1
6
Show member pathways
9.2GSR, CAT, SOD1
7
Show member pathways
9.2GSR, CAT, SOD1
8
Show member pathways
thioredoxin pathway37
9.2GSR, CAT, SOD1
99.2GSR, CAT, SOD1

Compounds for genes affiliated with Diabetic Cataract

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 28IUPHAR
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Compounds related to Diabetic Cataract according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1tert-butylhydroperoxide449.8GSR, CAT, G6PD
2ionol449.6GSR, CAT, SOD1
3propyl gallate449.6CAT, SOD1, GSR
4guaiacol44 2410.6GSR, CAT, SOD1
5glutathion449.6SOD1, GSR, CAT
63-amino-1,2,4-triazole449.6GSR, SOD1, CAT
7sodium azide449.6CAT, SOD1, G6PD
8benzyl alcohol44 1110.6AKR1B1, CAT, SOD1
9fenton449.6GSR, SOD1, CAT
10probucol44 1110.5CAT, AKR1B1, SOD1
11ebselen449.5GSR, SOD1, CAT
12fpl 55712449.5SOD1, CAT
13nadp+449.5SORD, G6PD, AKR1B1, GSR
14selenite449.5GSR, CAT, SOD1
15tetrahydrobiopterin44 24 1111.5SOD1, AKR1B1, CAT
16NADP249.5G6PD, GSR, CAT, AKR1B1
17ubiquinone449.4CAT, GSR, SOD1
18thiobarbituric acid449.4SOD1, G6PD, CAT, GSR
19dehydroascorbic acid44 1110.4SOD1, G6PD, GSR, CAT
20gsno449.4GSR, AKR1B1, CAT, SOD1
21tocopherol449.4G6PD, CAT, SOD1, GSR
22gssg449.4GSR, CAT, G6PD, SOD1
23silymarin449.4AKR1B1, GSR, SOD1, CAT
24tbhq449.3KEAP1, GSR, CAT
25malondialdehyde449.3SOD1, G6PD, CAT, GSR
26uric acid44 2410.3SOD1, G6PD, CAT, GSR
27vitamin-e449.3SOD1, GSR, CAT, G6PD
28diphenyleneiodonium449.3CAT, G6PD, SOD1, SERPINF1
29alpha tocopherol449.2SOD1, CAT, G6PD, GSR
30u 83836e449.2SOD1, CAT
31quercetin44 61 24 1112.2GSR, CAT, AKR1B1, SOD1
32menadione44 24 1111.2CAT, SOD1, GSR, KEAP1
33alpha lipoic acid449.1GSR, SOD1, CAT, AKR1B1, G6PD
34sodium arsenite449.1GSR, SOD1, SORD, CAT
354-hydroxynonenal44 2410.1G6PD, CAT, GSR, SOD1, AKR1B1
36ascorbic acid44 2410.0G6PD, CAT, AKR1B1, GSR, SOD1
37arsenite44 2410.0MIP, SOD1, GSR, CAT
38glucose 6-phosphate44 249.9CAT, SOD1, SORD, GSR, G6PD
39indomethacin44 28 61 1111.9PPARD, GSR, CAT, AKR1B1, SOD1
40n acetylcysteine448.7SOD1, GSR, G6PD, AKR1B1, CAT, SERPINF1
41nadph44 249.7SERPINF1, GSR, CAT, AKR1B1, G6PD, SOD1
42superoxide44 249.6SOD1, SORD, G6PD, CAT, GSR
43creatinine448.6AKR1B1, SOD1, SORD, GSR, G6PD
44nadh44 24 1110.6GSR, SOD1, AKR1B1, CAT, G6PD, SORD
45mannitol44 119.6SOD1, SORD, G6PD, AKR1B1, MIP, CAT
46lactate448.3SOD1, GSR, MIP, CAT, SORD, AKR1B1
47glucose448.2G6PD, MIP, AKR1B1, SORD, SERPINF1, PPARD
48cysteine448.2CAT, GSR, SERPINF1, AKR1B1, MIP, SOD1
49h2o2448.0AKR1B1, GSR, KEAP1, SERPINF1, G6PD, CAT
50oxygen44 248.5MIP, KEAP1, GSR, CAT, AKR1B1, G6PD

GO Terms for genes affiliated with Diabetic Cataract

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Cellular components related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.1GSR, AKR1B1, G6PD, SORD, SOD1, SERPINF1

Biological processes related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.7CAT, PPARD
2glutathione metabolic processGO:0067499.2GSR, G6PD, SOD1
3embryo implantationGO:0075669.1SOD1, PPARD

Molecular functions related to Diabetic Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NADP bindingGO:0506619.6GSR, CAT, G6PD

Products for genes affiliated with Diabetic Cataract

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  • Antibodies
  • Proteins
  • Lysates

Sources for Diabetic Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet