MCID: DBT081
MIFTS: 27

Diabetic Encephalopathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Encephalopathy

MalaCards integrated aliases for Diabetic Encephalopathy:

Name: Diabetic Encephalopathy 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050850

Summaries for Diabetic Encephalopathy

Disease Ontology : 12 A brain disease that is characterized by functional impairment of cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with diabetes.

MalaCards based summary : Diabetic Encephalopathy is related to encephalopathy and neuronitis. An important gene associated with Diabetic Encephalopathy is CREB1 (CAMP Responsive Element Binding Protein 1), and among its related pathways/superpathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and ATF-2 transcription factor network. Affiliated tissues include brain, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Diabetic Encephalopathy

Diseases related to Diabetic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 encephalopathy 10.4
2 neuronitis 9.9
3 diabetic neuropathy 9.8 GDNF INS
4 cerebral atrophy 9.7
5 cerebritis 9.7
6 alzheimer disease 9.6
7 diabetes mellitus 9.6
8 hyperglycemia 9.6

Graphical network of the top 20 diseases related to Diabetic Encephalopathy:



Diseases related to Diabetic Encephalopathy

Symptoms & Phenotypes for Diabetic Encephalopathy

MGI Mouse Phenotypes related to Diabetic Encephalopathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 CREB1 DLG4 GDNF INS MAD2L2 MYLK
2 growth/size/body region MP:0005378 9.7 CREB1 DLG4 GCLC GDNF INS MAD2L2
3 homeostasis/metabolism MP:0005376 9.5 CREB1 DLG4 GCLC GLO1 INS MAD2L2
4 nervous system MP:0003631 9.17 SHANK1 CREB1 DLG4 GCLC GDNF INS

Drugs & Therapeutics for Diabetic Encephalopathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Early Warning System for the Diabetic Encephalopathy Recruiting NCT02420470

Search NIH Clinical Center for Diabetic Encephalopathy

Genetic Tests for Diabetic Encephalopathy

Anatomical Context for Diabetic Encephalopathy

MalaCards organs/tissues related to Diabetic Encephalopathy:

38
Brain

Publications for Diabetic Encephalopathy

Articles related to Diabetic Encephalopathy:

(show all 38)
# Title Authors Year
1
Role of microglia-neuron interactions in diabetic encephalopathy. ( 29247713 )
2017
2
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. ( 28782427 )
2017
3
Mathematical model of diabetic encephalopathy. ( 29203738 )
2017
4
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( 28560538 )
2017
5
Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat. ( 28609588 )
2017
6
Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. ( 28456145 )
2017
7
Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus. ( 27914525 )
2016
8
Physiological targets for the treatment of diabetic encephalopathy. ( 27121380 )
2016
9
Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy. ( 27793043 )
2016
10
A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. ( 26867655 )
2016
11
Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat. ( 26426748 )
2015
12
Role of the Insulin-Like Growth Factor Type 1 Receptor in the Pathogenesis of Diabetic Encephalopathy. ( 26089889 )
2015
13
GABAergic Modulation in Diabetic Encephalopathy-Related Depression. ( 26365139 )
2015
14
The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression. ( 26199947 )
2015
15
A novel role for the calcium sensing receptor in rat diabetic encephalopathy. ( 25547907 )
2015
16
Inflammatory Macrophages Promotes Development of Diabetic Encephalopathy. ( 26113412 )
2015
17
Upregulation of pa89Akt by glial cell linea89derived neurotrophic factor ameliorates cell apoptosis in the hippocampus of rats with streptozotocina89induced diabetic encephalopathy. ( 26549420 )
2015
18
Retraction. Francis GJ, Martinez JA, Liu WQ, Xu K, Ayer A, Fine J, Tuor UI, Glazner G, Hanson LR, Frey WH 2nd, Toth C. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008 Dec;131(Pt 12):3311a8934. doi:10.1093/brain/awn288. ( 24860127 )
2014
19
Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. ( 25114929 )
2014
20
Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain. ( 25431174 )
2014
21
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. ( 24291733 )
2014
22
L-type calcium channel blocker ameliorates diabetic encephalopathy by modulating dysregulated calcium homeostasis. ( 25267297 )
2014
23
Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 24041458 )
2013
24
Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats. ( 25206401 )
2013
25
Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 23791853 )
2013
26
Effects of amyloid precursor protein 17 peptide on the protection of diabetic encephalopathy and improvement of glycol metabolism in the diabetic rat. ( 23844373 )
2013
27
Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. ( 23875897 )
2013
28
Axonal and dendritic changes are associated with diabetic encephalopathy in rats: an important risk factor for Alzheimer's disease. ( 23302655 )
2013
29
Neuroprotective properties of aucubin in diabetic rats and diabetic encephalopathy rats. ( 22810648 )
2012
30
C-peptide and diabetic encephalopathy. ( 21703121 )
2011
31
Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats. ( 19852947 )
2010
32
Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy. ( 20838865 )
2010
33
Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide. ( 19557294 )
2009
34
Aucubin prevents loss of hippocampal neurons and regulates antioxidative activity in diabetic encephalopathy rats. ( 19140154 )
2009
35
Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide. ( 20039010 )
2009
36
Neuroprotection in diabetic encephalopathy. ( 20145418 )
2009
37
Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. ( 18802743 )
2008
38
Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. ( 19015157 )
2008

Variations for Diabetic Encephalopathy

Expression for Diabetic Encephalopathy

Search GEO for disease gene expression data for Diabetic Encephalopathy.

Pathways for Diabetic Encephalopathy

Pathways related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 CREB1 INS
2 11 CREB1 INS
3 10.8 CREB1 INS
4 10.54 CREB1 GDNF
5 10.15 CREB1 DLG4

GO Terms for Diabetic Encephalopathy

Cellular components related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory synapse GO:0060076 8.96 DLG4 SHANK1
2 ionotropic glutamate receptor complex GO:0008328 8.62 DLG4 SHANK1

Biological processes related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.67 DLG4 GDNF INS
2 social behavior GO:0035176 9.55 DLG4 SHANK1
3 glutathione metabolic process GO:0006749 9.54 GCLC GLO1
4 neuromuscular process controlling balance GO:0050885 9.52 DLG4 SHANK1
5 positive regulation of cell differentiation GO:0045597 9.51 GDNF INS
6 response to activity GO:0014823 9.48 CREB1 GCLC
7 negative regulation of protein catabolic process GO:0042177 9.46 INS MAD2L2
8 positive regulation of excitatory postsynaptic potential GO:2000463 9.43 DLG4 SHANK1
9 dendritic spine morphogenesis GO:0060997 9.4 DLG4 SHANK1
10 positive regulation of long-term synaptic potentiation GO:1900273 9.37 CREB1 INS
11 protein localization to synapse GO:0035418 9.32 DLG4 SHANK1
12 vocalization behavior GO:0071625 9.26 DLG4 SHANK1
13 cellular response to hepatocyte growth factor stimulus GO:0035729 9.16 CREB1 GCLC
14 positive regulation of lipid biosynthetic process GO:0046889 8.96 CREB1 INS
15 negative regulation of transcription by competitive promoter binding GO:0010944 8.62 CREB1 MAD2L2

Molecular functions related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.16 DLG4 SHANK1
2 RNA polymerase II activating transcription factor binding GO:0001102 8.96 CREB1 MAD2L2
3 ionotropic glutamate receptor binding GO:0035255 8.62 DLG4 SHANK1

Sources for Diabetic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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