MCID: DBT081
MIFTS: 27

Diabetic Encephalopathy

Categories: Neuronal diseases

Aliases & Classifications for Diabetic Encephalopathy

MalaCards integrated aliases for Diabetic Encephalopathy:

Name: Diabetic Encephalopathy 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0050850

Summaries for Diabetic Encephalopathy

Disease Ontology : 12 A brain disease that is characterized by functional impairment of cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with diabetes.

MalaCards based summary : Diabetic Encephalopathy is related to encephalopathy and diffuse large b-cell lymphoma. An important gene associated with Diabetic Encephalopathy is CREB1 (CAMP Responsive Element Binding Protein 1), and among its related pathways/superpathways are Sterol Regulatory Element-Binding Proteins (SREBP) signalling and ATF-2 transcription factor network. The drugs Neomycin and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Diabetic Encephalopathy

Diseases related to Diabetic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 encephalopathy 10.3
2 diffuse large b-cell lymphoma 10.1 GDNF INS
3 neuronitis 9.8
4 cerebritis 9.7
5 cerebral atrophy 9.7
6 hyperglycemia 9.5
7 sexual disorder 9.2 DLG4 GLO1 SHANK1
8 chronic venous insufficiency 6.3 CREB1 DLG4 GCLC GDNF GLO1 INS

Graphical network of the top 20 diseases related to Diabetic Encephalopathy:



Diseases related to Diabetic Encephalopathy

Symptoms & Phenotypes for Diabetic Encephalopathy

MGI Mouse Phenotypes related to Diabetic Encephalopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 CREB1 DLG4 GDNF INS MAD2L2 MYLK
2 growth/size/body region MP:0005378 9.7 CREB1 DLG4 GCLC GDNF INS MAD2L2
3 homeostasis/metabolism MP:0005376 9.5 CREB1 DLG4 GCLC GLO1 INS MAD2L2
4 nervous system MP:0003631 9.17 CREB1 DLG4 GCLC GDNF INS MAD2L2

Drugs & Therapeutics for Diabetic Encephalopathy

Drugs for Diabetic Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved 1404-04-2 8378
2
Rifaximin Approved, Investigational 80621-81-4 6436173
3 Anti-Bacterial Agents
4 Anti-Infective Agents
5 Gastrointestinal Agents
6 Nucleic Acid Synthesis Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Role of Methane in Glycemic Control Completed NCT01638429 Neomycin and Rifaximin
2 The Early Warning System for the Diabetic Encephalopathy Recruiting NCT02420470
3 Timing for Arteriovenous Fistula Creation and Its Effect on Target Organs in Patients With Chronic Renal Failure Not yet recruiting NCT02259296

Search NIH Clinical Center for Diabetic Encephalopathy

Genetic Tests for Diabetic Encephalopathy

Anatomical Context for Diabetic Encephalopathy

MalaCards organs/tissues related to Diabetic Encephalopathy:

39
Brain

Publications for Diabetic Encephalopathy

Articles related to Diabetic Encephalopathy:

(show all 36)
id Title Authors Year
1
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. ( 28782427 )
2017
2
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( 28560538 )
2017
3
Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. ( 28456145 )
2017
4
Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat. ( 28609588 )
2017
5
Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy. ( 27793043 )
2016
6
Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus. ( 27914525 )
2016
7
A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. ( 26867655 )
2016
8
Physiological targets for the treatment of diabetic encephalopathy. ( 27121380 )
2016
9
Role of the Insulin-Like Growth Factor Type 1 Receptor in the Pathogenesis of Diabetic Encephalopathy. ( 26089889 )
2015
10
Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat. ( 26426748 )
2015
11
A novel role for the calcium sensing receptor in rat diabetic encephalopathy. ( 25547907 )
2015
12
The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression. ( 26199947 )
2015
13
GABAergic Modulation in Diabetic Encephalopathy-Related Depression. ( 26365139 )
2015
14
Inflammatory Macrophages Promotes Development of Diabetic Encephalopathy. ( 26113412 )
2015
15
Upregulation of pa89Akt by glial cell linea89derived neurotrophic factor ameliorates cell apoptosis in the hippocampus of rats with streptozotocina89induced diabetic encephalopathy. ( 26549420 )
2015
16
L-type calcium channel blocker ameliorates diabetic encephalopathy by modulating dysregulated calcium homeostasis. ( 25267297 )
2014
17
Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain. ( 25431174 )
2014
18
Cerebroprotective effects of ibuprofen on diabetic encephalopathy in rats. ( 24291733 )
2014
19
Retraction. Francis GJ, Martinez JA, Liu WQ, Xu K, Ayer A, Fine J, Tuor UI, Glazner G, Hanson LR, Frey WH 2nd, Toth C. Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. Brain 2008 Dec;131(Pt 12):3311a8934. doi:10.1093/brain/awn288. ( 24860127 )
2014
20
Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. ( 25114929 )
2014
21
Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 24041458 )
2013
22
Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats. ( 23875897 )
2013
23
Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats. ( 25206401 )
2013
24
Effects of amyloid precursor protein 17 peptide on the protection of diabetic encephalopathy and improvement of glycol metabolism in the diabetic rat. ( 23844373 )
2013
25
Axonal and dendritic changes are associated with diabetic encephalopathy in rats: an important risk factor for Alzheimer's disease. ( 23302655 )
2013
26
Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. ( 23791853 )
2013
27
Neuroprotective properties of aucubin in diabetic rats and diabetic encephalopathy rats. ( 22810648 )
2012
28
C-peptide and diabetic encephalopathy. ( 21703121 )
2011
29
Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy. ( 20838865 )
2010
30
Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats. ( 19852947 )
2010
31
Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide. ( 19557294 )
2009
32
Aucubin prevents loss of hippocampal neurons and regulates antioxidative activity in diabetic encephalopathy rats. ( 19140154 )
2009
33
Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide. ( 20039010 )
2009
34
Neuroprotection in diabetic encephalopathy. ( 20145418 )
2009
35
Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy. ( 19015157 )
2008
36
Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. ( 18802743 )
2008

Variations for Diabetic Encephalopathy

Expression for Diabetic Encephalopathy

Search GEO for disease gene expression data for Diabetic Encephalopathy.

Pathways for Diabetic Encephalopathy

Pathways related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.18 CREB1 INS
2 11 CREB1 INS
3 10.8 CREB1 INS
4 10.54 CREB1 GDNF
5 10.15 CREB1 DLG4

GO Terms for Diabetic Encephalopathy

Cellular components related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 excitatory synapse GO:0060076 8.96 DLG4 SHANK1
2 ionotropic glutamate receptor complex GO:0008328 8.62 DLG4 SHANK1

Biological processes related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.65 DLG4 GDNF INS
2 glutathione metabolic process GO:0006749 9.55 GCLC GLO1
3 social behavior GO:0035176 9.54 DLG4 SHANK1
4 positive regulation of cell differentiation GO:0045597 9.52 GDNF INS
5 neuromuscular process controlling balance GO:0050885 9.51 DLG4 SHANK1
6 response to activity GO:0014823 9.49 CREB1 GCLC
7 negative regulation of protein catabolic process GO:0042177 9.46 INS MAD2L2
8 positive regulation of excitatory postsynaptic potential GO:2000463 9.43 DLG4 SHANK1
9 dendritic spine morphogenesis GO:0060997 9.4 DLG4 SHANK1
10 cellular response to hepatocyte growth factor stimulus GO:0035729 9.32 CREB1 GCLC
11 vocalization behavior GO:0071625 9.26 DLG4 SHANK1
12 protein localization to synapse GO:0035418 9.16 DLG4 SHANK1
13 positive regulation of long-term synaptic potentiation GO:1900273 9.07 CREB1
14 positive regulation of lipid biosynthetic process GO:0046889 8.96 CREB1 INS
15 negative regulation of transcription by competitive promoter binding GO:0010944 8.62 CREB1 MAD2L2

Molecular functions related to Diabetic Encephalopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.16 DLG4 SHANK1
2 RNA polymerase II activating transcription factor binding GO:0001102 8.96 CREB1 MAD2L2
3 ionotropic glutamate receptor binding GO:0035255 8.62 DLG4 SHANK1

Sources for Diabetic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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