MCID: DBT062
MIFTS: 46

Diabetic Foot Ulcers malady

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Summaries for Diabetic Foot Ulcers

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Wikipedia:65 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

MalaCards based summary: Diabetic Foot Ulcers is related to hypertrophic scars and melanoma. An important gene associated with Diabetic Foot Ulcers is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Renal cell carcinoma. The compounds dithranol and ttnpb have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Diabetic Foot Ulcers

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Diabetic Foot Ulcers, Aliases & Descriptions:

Name: Diabetic Foot Ulcers 30 44 62


Related Diseases for Diabetic Foot Ulcers

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Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic scars30.3TGFB3, KRT16
2melanoma29.8GJA1, PDGFB, TGFB3
3blindness10.6
4osteomyelitis10.6
5critical limb ischemia10.4
6ischemia10.4
7endotheliitis10.4
8arthropathy10.3
9neuropathy10.3
10pneumonia10.3
11steatocystoma multiplex10.2KRT16, KRT10
12bowen syndrome10.2KRT16, KRT10
13epidermolytic hyperkeratosis10.2KRT16, KRT10
14epidermolysis bullosa simplex10.2KRT16, KRT10
15nonepidermolytic palmoplantar keratoderma10.2KRT16, KRT10
16keratosis10.2KRT10, KRT16
17lichen planus10.2KRT16, KRT10
18cholesteatoma10.2KRT10, KRT16
19peripheral vascular disease10.2
20diabetes mellitus10.2
21lymphedema10.2
22limb ischemia10.2
23peripheral artery disease10.2
24amelanotic melanoma10.2
25artery disease10.2
26hyperglycemia10.2
27kidney disease10.2
28peripheral neuropathy10.2
29retinitis10.2
30scleritis10.2
31tetanus10.2
32vascular disease10.2
33klebsiella10.2
34papilloma10.2GJA1, KRT10
35basal cell carcinoma10.1KRT10, KRT16
36glioblastoma multiforme10.1PDGFB, GJA1
37rhabdomyosarcoma10.1PDGFB, GJA1
38noonan syndrome10.1GJA1, PDGFB
39pulmonary fibrosis10.0PDGFB, TGFB3
40uterine fibroid10.0GJA1, TGFB3
41leiomyoma10.0TGFB3, GJA1
42systemic scleroderma10.0PDGFB, TGFB3
43palmoplantar keratosis10.0GJA1, KRT16, KRT10
44skin disease10.0GJA1, KRT16, KRT10
45cataract10.0TGFB3, GJA1
46lung benign neoplasm9.9GJA1, PDGFB
47liver cirrhosis9.9PDGFB, TGFB3
48osteosarcoma9.8GJA1, TGFB3, PDGFB
49adenocarcinoma9.7KRT10, TGFB3, PDGFB, GJA1
50tongue squamous cell carcinoma9.4TGFB3, PDGFB, GJA1, KRT10, KRT16

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to diabetic foot ulcers

Symptoms for Diabetic Foot Ulcers

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Drugs & Therapeutics for Diabetic Foot Ulcers

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Genetic Tests for Diabetic Foot Ulcers

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Anatomical Context for Diabetic Foot Ulcers

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MalaCards organs/tissues related to Diabetic Foot Ulcers:

32
Skin, Bone, Bone marrow, Colon, Testes, Endothelial, Heart, Kidney

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Diabetic Foot Ulcers or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7KRT10, GJA1, TGFB3
2MP:00107718.5PDGFB, GJA1, KRT10, KRT16
3MP:00053828.2KRT16, KRT10, GJA1, TGFB3
4MP:00107687.4TGFB3, PDGFB, GJA1, KRT10, KRT16

Publications for Diabetic Foot Ulcers

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Articles related to Diabetic Foot Ulcers:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
High matrix metalloproteinase levels are associated with dermal graft failure in diabetic foot ulcers. (25106443)
2014
2
Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers. (25168880)
2014
3
Efficacy of topical application of beta urogastrone (recombinant human epidermal growth factor) in Wagner's Grade 1 and 2 diabetic foot ulcers: Comparative analysis of 50 patients. (25097397)
2014
4
IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers. (23671876)
2013
5
Diabetic foot ulcer microbiome: one small step for molecular microbiology . . . One giant leap for understanding diabetic foot ulcers? (23431007)
2013
6
Hydrocolloid dressings for healing diabetic foot ulcers. (23922167)
2013
7
Increasing incidence of Gram-negative organisms in bacterial agents isolated from diabetic foot ulcers. (24129622)
2013
8
Understanding diabetic foot ulcers. (24002373)
2013
9
Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. (24391454)
2013
10
The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. (23566071)
2013
11
Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. (24358275)
2013
12
Topical honey for diabetic foot ulcers. (23795214)
2013
13
Prevention and management of neuropathic diabetic foot ulcers. (24128251)
2013
14
Efficacy of low level laser therapy on wound healing in patients with chronic diabetic foot ulcers-a randomised control trial. (24082586)
2012
15
A pilot study evaluating noncontact low frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers. (23163982)
2012
16
A retrospective study of diabetic foot ulcers treated with hyperbaric oxygen therapy. (22372584)
2012
17
Diffuse near-infrared spectroscopy prediction of healing in diabetic foot ulcers: a human study and cost analysis. (23110417)
2012
18
Role of negative pressure wound therapy in healing of diabetic foot ulcers. (22022646)
2011
19
Prospective randomized controlled study of a Chinese herbal medicine compound Tangzu Yuyang Ointment for chronic diabetic foot ulcers: a preliminary report. (21129474)
2011
20
The impact of creatinine clearance on the outcome of diabetic foot ulcers in north Indian tertiary care hospital. (22813563)
2011
21
Foam dressings for healing diabetic foot ulcers. (21901731)
2011
22
Bioengineered skin in diabetic foot ulcers. (20380651)
2010
23
Diabetic foot ulcers treated with becaplermin and TheraGauze, a moisture-controlling smart dressing: a randomized, multicenter, prospective analysis. (20479444)
2010
24
Does cell therapy and tissue engineering represent a promising treatment of diabetic foot ulcers? (20437823)
2010
25
Role of early surgical revascularization in the management of refractory diabetic foot ulcers in patients without overt ischemic limbs. (20152756)
2010
26
Clinical signs of infection in diabetic foot ulcers with high microbial load. (19147524)
2009
27
Clinical effectiveness of an acellular dermal regenerative tissue matrix compared to standard wound management in healing diabetic foot ulcers: a prospective, randomised, multicentre study. (19368581)
2009
28
An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. (19065083)
2008
29
Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers: a 6.5-year follow-up study. (18390801)
2008
30
Wound-related pain is underestimated in patients with diabetic foot ulcers. (18947021)
2008
31
Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. (18387077)
2008
32
Using honey to heal diabetic foot ulcers. (18600072)
2008
33
Virulence potential of Staphylococcus aureus strains isolated from diabetic foot ulcers: a new paradigm. (18809632)
2008
34
Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. (18400121)
2008
35
A comparison of the health-related quality of life in patients with diabetic foot ulcers, with a diabetes group and a nondiabetes group from the general population. (17091370)
2007
36
A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers. (18044080)
2007
37
A feasibility study of UMTS mobile phones for supporting nurses doing home visits to patients with diabetic foot ulcers. (17059653)
2006
38
Diabetic foot ulcers. (16484268)
2006
39
The efficacy of Apligraf in the treatment of diabetic foot ulcers. (16799383)
2006
40
Tetanus prophylaxis for diabetic foot ulcers. (17067894)
2006
41
Telemedical treatment at home of diabetic foot ulcers. (16375785)
2005
42
Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infections. (15659542)
2005
43
Optimal treatment of infected diabetic foot ulcers. (15493949)
2004
44
The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcers. (15562198)
2004
45
Diabetic foot ulcers. (12737879)
2003
46
Growth factors in the treatment of diabetic foot ulcers. (12555288)
2003
47
A comparison of plantar pressure in patients with diabetic foot ulcers using different hosiery. (15871969)
2002
48
Effects of felted foam on plantar pressures in the treatment of neuropathic diabetic foot ulcers. (11723100)
2001
49
Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. (10727985)
2000
50
Diabetic foot ulcers. A guide to treatment. (11702311)
2000

Variations for Diabetic Foot Ulcers

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Expression for genes affiliated with Diabetic Foot Ulcers

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Expression patterns in normal tissues for genes affiliated with Diabetic Foot Ulcers

Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for genes affiliated with Diabetic Foot Ulcers

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Pathways related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2PDGFB, TGFB3
29.2PDGFB, TGFB3
3
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.1GJA1, TGFB3
4
Show member pathways
MAPK signaling pathway37
8.6PDGFB, TGFB3, HSPA1L

Compounds for genes affiliated with Diabetic Foot Ulcers

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Compounds related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1dithranol449.8KRT16, KRT10
2ttnpb44 28 1111.8KRT16, GJA1
3calcipotriol44 61 28 1112.8KRT10, KRT16
4isotretinoin44 1110.7KRT16, KRT10
5isoleucine449.6KRT10, GJA1
6polyglycolic acid449.6TGFB3, PDGFB
7bromodeoxyuridine449.4KRT10, GJA1, PDGFB
8tcdd449.4KRT10, TGFB3
91,25 dihydroxy vitamin d3449.3GJA1, KRT10, KRT16
10calcitriol44 61 24 1112.3KRT16, KRT10, GJA1
11retinoid449.3KRT16, KRT10, GJA1
12tgf beta1449.2PDGFB, TGFB3
13proline449.2GJA1, KRT10, KRT16
14progestin449.1TGFB3, GJA1
15ribonucleic acid449.0GJA1, PDGFB, TGFB3
16thymidine44 249.9GJA1, PDGFB, TGFB3
17serine448.7PDGFB, GJA1, KRT10, KRT16
18progesterone44 28 61 24 1112.6TGFB3, PDGFB, GJA1, KRT10
19dexamethasone44 50 28 1111.6TGFB3, PDGFB, GJA1, KRT10
20steroid448.6KRT16, KRT10, TGFB3
21estrogen448.6TGFB3, PDGFB, GJA1, KRT10
22nitric oxide44 24 1110.5TGFB3, PDGFB, GJA1, KRT16
23retinoic acid44 249.4TGFB3, GJA1, KRT10, KRT16
24vegf448.4GJA1, PDGFB, TGFB3
25tyrosine448.3KRT10, GJA1, PDGFB, TGFB3
26paraffin448.1KRT16, KRT10, GJA1, PDGFB, TGFB3

GO Terms for genes affiliated with Diabetic Foot Ulcers

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Cellular components related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5KRT16, KRT10
2platelet alpha granule lumenGO:0310938.9PDGFB, TGFB3

Biological processes related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glomerular filtrationGO:0031049.7GJA1, PDGFB
2positive regulation of DNA replicationGO:0457409.4PDGFB, TGFB3
3positive regulation of cell divisionGO:0517819.4PDGFB, TGFB3
4cell growthGO:0160499.3PDGFB, TGFB3
5platelet degranulationGO:0025769.2TGFB3, PDGFB
6heart developmentGO:0075079.2GJA1, PDGFB
7response to hypoxiaGO:0016669.2PDGFB, TGFB3
8transforming growth factor beta receptor signaling pathwayGO:0071799.1PDGFB, TGFB3

Products for genes affiliated with Diabetic Foot Ulcers

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  • Antibodies
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Sources for Diabetic Foot Ulcers

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet