Aliases & Classifications for Diabetic Foot Ulcers

MalaCards integrated aliases for Diabetic Foot Ulcers:

Name: Diabetic Foot Ulcers 37 51
Diabetic Foot Ulcer 69
Diabetic Foot 69

External Ids:

Summaries for Diabetic Foot Ulcers

MalaCards based summary : Diabetic Foot Ulcers, also known as diabetic foot ulcer, is related to peripheral artery disease and chlamydia, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with Diabetic Foot Ulcers is PDGFB (Platelet Derived Growth Factor Subunit B), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Endometrial cancer. The drugs Amoxicillin and Aztreonam have been mentioned in the context of this disorder. Affiliated tissues include Bone, skin and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

Related Diseases for Diabetic Foot Ulcers

Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 peripheral artery disease 29.9 CRP IL6
2 chlamydia 29.2 CRP IL6
3 arteries, anomalies of 29.2 CRP IL6 MMP9
4 laryngitis 10.2 IL6 TGFB1
5 posterior urethral valves 10.2 IL6 TGFB1
6 gingival disease 10.2 IL6 TGFB1
7 localized scleroderma 10.2 IL6 TGFB1
8 idiopathic neutropenia 10.2 IL6 TGFB1
9 prostatitis 10.2 IL6 TGFB1
10 rheumatic heart disease 10.2 IL6 TGFB1
11 osteomyelitis 10.2
12 ischemia 10.2
13 carpal tunnel syndrome 10.2 IL6 TGFB1
14 tuberculous meningitis 10.2 MMP9 TGFB1
15 acute transverse myelitis 10.1 IL6 MMP9
16 back pain 10.1 IL6 MMP9
17 pneumoconiosis 10.1 IL6 TGFB1
18 photokeratitis 10.1 IL6 MMP9
19 transverse myelitis 10.1 IL6 MMP9
20 esophagitis 10.1 IL6 TGFB1
21 rosacea 10.1 IL6 MMP9
22 hydronephrosis 10.1 MMP9 TGFB1
23 blood group, i system 10.1
24 arteriovenous malformation 10.1 IL6 MMP9
25 inguinal hernia 10.1 IL6 MMP9
26 intervertebral disc disease 10.0 IL6 MMP9
27 tropical spastic paraparesis 10.0 IL6 MMP9
28 limb ischemia 10.0
29 endotheliitis 10.0
30 rapidly progressive glomerulonephritis 10.0 CRP TGFB1
31 spinal cord injury 10.0 IL6 MMP9
32 severe pre-eclampsia 10.0 LEPR MMP9
33 aortic disease 10.0 IL6 MMP9
34 calcific tendinitis 10.0 CRP TGFB1
35 gingivitis 10.0 IL6 MMP9
36 bone fracture 10.0 CRP TGFB1
37 cold agglutinin disease 10.0 CRP IL6
38 cryopyrin-associated periodic syndrome 10.0 CRP IL6
39 neutrophilia, hereditary 10.0 CRP IL6
40 acute cholangitis 10.0 CRP IL6
41 cardiogenic shock 10.0 CRP IL6
42 uremic pruritus 10.0 CRP IL6
43 spinal disease 10.0 CRP IL6
44 episodic pain syndrome, familial, 1 10.0
45 critical limb ischemia 10.0
46 diabetes mellitus 10.0
47 neuropathy 10.0
48 castleman disease 10.0 CRP IL6
49 angina pectoris 10.0 CRP IL6
50 chronic fatigue syndrome 10.0 IL6 TGFB1

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to Diabetic Foot Ulcers

Symptoms & Phenotypes for Diabetic Foot Ulcers

UMLS symptoms related to Diabetic Foot Ulcers:


sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pain, muscle cramp, headache, edema, chest pain, back pain, angina pectoris

MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 LEPR TGFB1 MMP9 CRP IL6 PDGFB
2 homeostasis/metabolism MP:0005376 9.95 IL6 PDGFB LEPR TGFB1 CRP MMP9
3 immune system MP:0005387 9.93 PDGFB LEPR TGFB1 MMP9 CRP IL6
4 integument MP:0010771 9.83 PDGFB LEPR TGFB1 MMP9 IL6
5 muscle MP:0005369 9.77 PDGFB LEPR TGFB1 MMP9 IL6
6 liver/biliary system MP:0005370 9.71 IL6 PDGFB LEPR TGFB1
7 renal/urinary system MP:0005367 9.65 LEPR TGFB1 MMP9 IL6 PDGFB
8 neoplasm MP:0002006 9.62 IL6 LEPR TGFB1 MMP9
9 reproductive system MP:0005389 9.55 IL6 PDGFB LEPR TGFB1 MMP9
10 respiratory system MP:0005388 9.35 LEPR TGFB1 MMP9 IL6 PDGFB
11 vision/eye MP:0005391 9.02 PDGFB LEPR TGFB1 MMP9 IL6

Drugs & Therapeutics for Diabetic Foot Ulcers

Drugs for Diabetic Foot Ulcers (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 293)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613 2171
2
Aztreonam Approved Phase 4,Phase 2 78110-38-0 5742832 5362041
3
Clindamycin Approved, Vet_approved Phase 4,Phase 2 18323-44-9 29029
4
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2 100986-85-4 149096
5
Linezolid Approved, Investigational Phase 4,Phase 2 165800-03-3 441401
6
Metronidazole Approved Phase 4,Phase 2 443-48-1 4173
7
Ofloxacin Approved Phase 4,Phase 3,Phase 2 82419-36-1 4583
8
Piperacillin Approved Phase 4,Phase 3,Phase 2 66258-76-2 43672
9
Tazobactam Approved Phase 4,Phase 3,Phase 2 89786-04-9 123630
10
Ciprofloxacin Approved, Investigational Phase 4,Phase 2,Phase 1 85721-33-1 2764
11
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
12
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
13
Daptomycin Approved, Investigational Phase 4,Phase 3,Phase 2 103060-53-3 16129629
14
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 32051 23994
15
Alginic acid Approved, Experimental, Investigational Phase 4,Phase 1,Phase 2 9005-32-7
16
Petrolatum Approved, Investigational Phase 4 8009-03-8
17
Cefepime Approved, Investigational Phase 4,Phase 2 88040-23-7 5479537
18
Cefotaxime Approved Phase 4 63527-52-6 5742673 456256
19
Cefoxitin Approved Phase 4 35607-66-0 441199
20
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
21
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 564-25-0 54671203
22
Fusidic Acid Approved, Investigational Phase 4 6990-06-3 3000226
23
Rifampin Approved Phase 4 13292-46-1 5381226 5458213
24
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
25
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
26
Sulbactam Approved Phase 4 68373-14-8
27 Sultamicillin Approved, Investigational Phase 4 76497-13-7
28
Ertapenem Approved, Investigational Phase 4,Phase 3 153832-46-3 150610
29
Vancomycin Approved Phase 4,Phase 3,Phase 2 1404-90-6 14969 441141
30
Saxagliptin Approved Phase 4 361442-04-8 11243969
31
Dimenhydrinate Approved Phase 4 523-87-5 441281
32
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 10909430 439542
33
Thrombin Approved, Investigational Phase 4
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
35
leucovorin Approved, Nutraceutical Phase 4,Phase 2 58-05-9 143 6006
36
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
37 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
38 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 1,Phase 2
39 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
40 Antitubercular Agents Phase 4,Phase 3,Phase 2
41 Clavulanic Acid Phase 4,Phase 3,Phase 2
42 Clindamycin palmitate Phase 4,Phase 2
43 Clindamycin phosphate Phase 4,Phase 2
44 Gentamicins Phase 4,Phase 3,Phase 2,Phase 1
45 Mitogens Phase 4,Phase 3,Phase 2,Phase 1
46 Antimalarials Phase 4,Phase 2,Phase 1
47 Antiparasitic Agents Phase 4,Phase 2,Phase 1
48 Antiprotozoal Agents Phase 4,Phase 2,Phase 1
49 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
50 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 525)

# Name Status NCT ID Phase Drugs
1 A Comparative Efficacy Study of DermaPure™ to Treat Diabetic Foot Ulcers Unknown status NCT02081352 Phase 4
2 Efficacy and Safety of Garamycin® Sponge (Gentamicin-Collagen Sponge) in Diabetic Patients With a Moderate or Severe Foot Ulcer Infection Unknown status NCT01951768 Phase 4 Garamycin Sponge (Gentamicin-Collagen sponge);Systemic Antibiotic
3 Outcomes of Non-infected Diabetic Foot Ulcers With/Without Antibiotics Unknown status NCT01418456 Phase 4 antibiotics
4 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
5 Santyl Applications to Diabetic Foot Ulcers Completed NCT02111291 Phase 4
6 Grafix® DFU: Open-Label Extension Option to Evaluate Safety & Efficacy of Grafix® for Chronic Diabetic Foot Ulcers Completed NCT01596920 Phase 4
7 LeucoPatch™ Study A Multicenter Study on the Effect of LeucoPatch™ in Diabetic Foot Ulcers Completed NCT01454401 Phase 4
8 Study of Oasis Ultra in Diabetic Foot Ulcers Completed NCT01835379 Phase 4
9 Diabetic Foot Ulcer Study on Topical Interventions Completed NCT02577900 Phase 4
10 Using Santyl on Diabetic Foot Ulcers Completed NCT01408277 Phase 4
11 Use of Santyl in Diabetic Foot Ulcers Completed NCT02581488 Phase 4
12 Evaluation of the Effect of Vivostat Platelet Rich Fibrin(PRF) in the Treatment of Diabetic Foot Ulcers Completed NCT00770939 Phase 4
13 TITLE: An Open, Non-comparative, Multi-centre Post Marketing Clinical Follow-up (PMCF) Investigation to Evaluate Performance and Safety on Diabetic Foot Ulcer, DFU, When Using Mepilex Transfer Ag as Intended Completed NCT01964521 Phase 4
14 A Study to Look at the Effects of Four Weeks of Treatment on the Healing of Diabetic Foot Ulcers Completed NCT01143714 Phase 4 Santyl
15 Enzymatic Versus (vs) Autolytic Debridement of Diabetic Foot Ulcers Completed NCT01143727 Phase 4 Santyl;Tegaderm Hydrogel
16 GrafixCORE®: Open-Label Study to Evaluate the Safety and Efficacy of GrafixCORE® for Complex Diabetic Foot Wounds Completed NCT02260609 Phase 4
17 Santyl vs. Sharp Debridement of Diabetic Foot Wounds Completed NCT01056198 Phase 4 Santyl
18 Antibiotic Treatment Duration for Non-Surgically-Treated Diabetic Foot Osteomyelitis Completed NCT02123628 Phase 4 duration of the antibiotic therapy
19 DermACELL in Subjects With Chronic Wounds of the Lower Extremities Completed NCT01970163 Phase 4
20 Trial of Vacuum Assisted Closure® Therapy in Amputation Wounds of the Diabetic Foot Completed NCT00224796 Phase 4
21 Diabetic Foot Ulcer. Effectiveness of Chlorhexidine Gluconate 0.125 % Compared With Sterile Deionized Water Completed NCT02097615 Phase 4
22 Evaluation of the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Full-Thickness, Neuropathic Diabetic Foot Ulcers Completed NCT00235196 Phase 4
23 GrafixPRIME® for the Treatment of Chronic Diabetic Foot Ulcers Completed NCT02675855 Phase 4
24 OASIS Wound Matrix (Oasis) Mechanism of Action Completed NCT00570141 Phase 4
25 Wound Edge Changes Following Treatment With Santyl Completed NCT01197898 Phase 4
26 Polydeoxyribonucleotide -Placentex Mastelli(Pdrn) for the Treatment of Diabetic Ulcers Completed NCT00638872 Phase 4 Polydeoxyribonucleotide
27 Study Evaluating the Safety and Efficacy of Piperacillin/Tazobactam and Ampicillin/Sulbactam in Patients With Diabetic Foot Infections Completed NCT00044746 Phase 4 Piperacillin/Tazobactam
28 Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers Completed NCT00953186 Phase 4
29 Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb Ulcers Completed NCT00521027 Phase 4
30 Skin Ulcers Treatment With an Handicraft Topical Device Completed NCT02512159 Phase 4
31 Target Site Pharmacokinetics of Ertapenem After Multiple Doses in Diabetes Patients With Soft Tissue Infection Completed NCT00658866 Phase 4
32 A Complicated Skin and Soft-tissue Infection Patient Registry Completed NCT00737269 Phase 4
33 Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers Completed NCT00621608 Phase 4
34 Evaluation of Woulgan in Diabetic Foot Ulcer Recruiting NCT02631512 Phase 4
35 A Feasibility Study of the ReGenerCell™ Autologous Cell Harvesting Device for Diabetic Foot Ulcers Recruiting NCT02799121 Phase 4
36 Chlorhexidine Gluconate Solution at 0.125% vs Placebo for the Healing of Grade IIB Ulcers of Diabetic Foot Recruiting NCT03209466 Phase 4 Chlorhexidine gluconate at 0.125%;Placebo Comparator with physiological saline sterile solution
37 Maggot Debridement Therapy Versus Conventional Dressing Therapy to Treat Diabetic Foot Ulcers Recruiting NCT02816749 Phase 4
38 Dipeptidyl Peptidase 4 Inhibition Facilitate Healing of Diabetic Ulcers Recruiting NCT02742233 Phase 4 saxagliptin;placebo
39 A Comparison of TCC-EZ Using Human Amnion Allograft vs TCC-EZ and Standard Wound Care in Treating Diabetic Foot Ulcers. Active, not recruiting NCT02344329 Phase 4
40 LeucoPatch in the Management of Hard-to-heal Diabetic Foot Ulcers Active, not recruiting NCT02224742 Phase 4
41 TruSkin®: Study for the Treatment of Chronic Diabetic Foot Ulcers Terminated NCT02936115 Phase 4
42 A Comparative Efficacy Study: Treatment for Non-healing Diabetic Foot Ulcers Terminated NCT01858545 Phase 4
43 Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens Terminated NCT01133600 Phase 4 Cubicin;Vancomycin
44 Januvia (Sitagliptin) in Healing Chronic Diabetic Foot Ulcers Terminated NCT02015910 Phase 4 Sitagliptin;Placebo
45 Use of INTEGRA™ Flowable Wound Matrix to Manage Diabetic Foot Ulcers Terminated NCT01108263 Phase 4 INTEGRA™ Flowable Matrix (Collagen)
46 RESPOND Restoring Equilibrium and Wound Stimulation to Promote Healing Of Non-healing DFUs Terminated NCT01608776 Phase 4
47 Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infections Terminated NCT00463801 Phase 4 Daptomycin
48 The Relationship of Hemoglobin A1c and Diabetic Wound Healing Terminated NCT01350102 Phase 4 Bacitracin;AmeriGel®
49 a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis Withdrawn NCT00578890 Phase 4
50 A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers Withdrawn NCT00338702 Phase 4

Search NIH Clinical Center for Diabetic Foot Ulcers

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Diabetic Foot Ulcers cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Foot Ulcers

Anatomical Context for Diabetic Foot Ulcers

MalaCards organs/tissues related to Diabetic Foot Ulcers:

38
Skin, Bone, Bone Marrow, Endothelial, Testes, Kidney, Colon
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Diabetic Foot Ulcers

Articles related to Diabetic Foot Ulcers:

(show top 50) (show all 674)
# Title Authors Year
1
Growth factors for diabetic foot ulcers: mixed treatment comparison analysis of randomized clinical trials. ( 29148070 )
2018
2
Update on management of diabetic foot ulcers. ( 29377202 )
2018
3
Association between QTc interval prolongation and outcomes of diabetic foot ulcers: Data from a 4-year follow-up study in China. ( 29382590 )
2018
4
Growth factors in the pathogenesis of diabetic foot ulcers. ( 28930549 )
2018
5
Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers. ( 29435274 )
2018
6
Specific PKC I^ II Inhibitor: One Stone Two Birds in the Treatment of Diabetic Foot Ulcers. ( 29440456 )
2018
7
CODIFI (Concordance in Diabetic Foot Ulcer Infection): a cross-sectional study of wound swab versus tissue sampling in infected diabetic foot ulcers in England. ( 29391370 )
2018
8
Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads. ( 29362914 )
2018
9
Use of Oxidized Regenerated Cellulose/Collagen Matrix in Chronic Diabetic Foot Ulcers: A Systematic Review. ( 29346146 )
2018
10
Financial burden of diabetic foot ulcers to world: a progressive topic to discuss always. ( 29344337 )
2018
11
The Impact of Three-month Training Programme on Foot Care and Self-efficacy of Patients with Diabetic Foot Ulcers. ( 28892930 )
2017
12
Next Generation DNA Sequencing of Tissues from Infected Diabetic Foot Ulcers. ( 28669650 )
2017
13
The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system correlates with cost of care for diabetic foot ulcers treated in a multidisciplinary setting. ( 29248237 )
2017
14
Comparison of the Neutrophil/Lymphocyte Ratio and C-Reactive Protein Levels in Patients With Amputation for Diabetic Foot Ulcers. ( 28682678 )
2017
15
Peripheral Vascular Disease in Patients with Diabetic Foot Ulcers - An Emerging Trend: A Prospective Study from North India. ( 28598042 )
2017
16
Effect of limb preservation status and body mass index on the survival of patients with limb-threatening diabetic foot ulcers. ( 27751708 )
2017
17
Bacterial Prevalence and Antibiotic Resistance in Clinical Isolates of Diabetic Foot Ulcers in the Northeast of Tamaulipas, Mexico. ( 28682727 )
2017
18
Advantages of early diagnosis of diabetic neuropathy in the prevention of diabetic foot ulcers. ( 29287839 )
2017
19
Efficacy and Time Sensitivity of Amniotic Membrane treatment in Patients with Diabetic Foot Ulcers: A Systematic Review and Meta-analysis. ( 28895073 )
2017
20
Management of chronic diabetic foot ulcers using platelet-rich plasma. ( 29244965 )
2017
21
A Retrospective Review of Adverse Events Related to Diabetic Foot Ulcers. ( 28657897 )
2017
22
Clostridial Collagenase for the Management of Diabetic Foot Ulcers: Results of Four Randomized Controlled Trials. ( 28862974 )
2017
23
Recent advances in biomaterials for the treatment of diabetic foot ulcers. ( 28829074 )
2017
24
Total Contact Cast System to Heal Diabetic Foot Ulcers. ( 28696493 )
2017
25
The prevalence and incidence of diabetic foot ulcers among five countries in the Arab world: a systematic review. ( 28880754 )
2017
26
Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. ( 29275068 )
2017
27
Vitamin D receptor gene FokI variant in diabetic foot ulcer and its relation with oxidative stress. ( 27836663 )
2017
28
A Retrospective Crossover Study of the Use of Aseptically Processed Placental Membrane in the Treatment of Chronic Diabetic Foot Ulcers. ( 28873060 )
2017
29
Staphylococcus Aureus Triggers Induction of MIR-15B-5P to Diminish DNA Repair and De-Regulate inflammatory Response in Diabetic Foot Ulcers. ( 29273315 )
2017
30
Atypical Microbial Isolates from Infected Diabetic Foot Ulcers: A Case Series from Greece. ( 29145535 )
2017
31
Intralesional Administration of Human Recombinant Epidermal Growth Factor Improves Healing and Reduces Amputations in Patients with Severe Diabetic Foot Ulcers. ( 29158856 )
2017
32
Nutritional Supplementation for Diabetic Foot Ulcers: The Big Challenge. ( 29251542 )
2017
33
The impact of team based interprofessional comprehensive assessments on the diagnosis and management of diabetic foot ulcers: A retrospective cohort study. ( 28949996 )
2017
34
Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome. ( 28904951 )
2017
35
Treatment strategies for neuroischaemic diabetic foot ulcers. ( 29275069 )
2017
36
Clinical and surgical characteristics of infected diabetic foot ulcers in a tertiary hospital of Mexico. ( 28904744 )
2017
37
NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem/progenitor cells. ( 28755516 )
2017
38
Expression and Influence of Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 and Vascular Endothelial Growth Factor in Diabetic Foot Ulcers. ( 28682675 )
2017
39
Amputation predictors in diabetic foot ulcers treated with hyperbaric oxygen. ( 28704149 )
2017
40
Association of Sociodemographic Factors with Spirituality and Hope in Patients with Diabetic Foot Ulcers. ( 27984272 )
2017
41
Potential of circulatory procalcitonin as a biomarker reflecting inflammation among South Indian diabetic foot ulcers. ( 28736121 )
2017
42
Cellular versus acellular grafts for diabetic foot ulcers: altering the protocol to improve recruitment to a comparative efficacy trial. ( 29232436 )
2017
43
Evidence based review of literature on detriments to healing of diabetic foot ulcers. ( 29202978 )
2017
44
The relationship of Interleukin-6 -174 G>C gene polymorphism in type 2 diabetic patients with and without diabetic foot ulcers in Turkish population. ( 28257947 )
2017
45
Differences in the daily activity of patients with diabetic foot ulcers compared to controls in their free-living environments. ( 28707412 )
2017
46
Influence of beliefs about health and illness on self-care and care-seeking in foreign-born people with diabetic foot ulcers: dissimilarities related to origin. ( 27827276 )
2016
47
Outcomes Following Advanced Wound Care for Diabetic Foot Ulcers: A Canadian Study. ( 27634016 )
2016
48
Systematic review and meta-analysis of skin substitutes in the treatment of diabetic foot ulcers: Highlights of a Cochrane Systematic review. ( 27062201 )
2016
49
Cost and mortality data of a regional limb salvage and hyperbaric medicine program for Wagner Grade 3 or 4 diabetic foot ulcers. ( 27000008 )
2016
50
Study of risk factors and outcome of patients with diabetic foot ulcers. ( 27728118 )
2016

Variations for Diabetic Foot Ulcers

Expression for Diabetic Foot Ulcers

Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for Diabetic Foot Ulcers

Pathways related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 IL6 MMP9 PDGFB TGFB1
2
Show member pathways
12.72 IL6 MMP9 PDGFB TGFB1
3
Show member pathways
12.48 MMP9 PDGFB TGFB1
4 12.46 IL6 MMP9 PDGFB TGFB1
5
Show member pathways
12.41 IL6 PDGFB TGFB1
6 12.16 IL6 PDGFB TGFB1
7
Show member pathways
12.07 IL6 LEPR PDGFB
8
Show member pathways
11.98 IL6 MMP9 PDGFB TGFB1
9 11.87 IL6 MMP9 TGFB1
10 11.7 IL6 PDGFB TGFB1
11 11.62 IL6 MMP9 TGFB1
12 11.55 IL6 MMP9 TGFB1
13
Show member pathways
11.46 PDGFB TGFB1
14 11.45 IL6 TGFB1
15 11.44 MMP9 TGFB1
16 11.44 IL6 MMP9
17
Show member pathways
11.42 IL6 MMP9
18 11.42 IL6 PDGFB TGFB1
19 11.31 IL6 TGFB1
20 11.29 IL6 TGFB1
21 11.27 IL6 MMP9
22 11.12 IL6 MMP9
23 11.04 IL6 TGFB1
24
Show member pathways
11.03 CRP LEPR
25 10.93 MMP9 PDGFB
26 10.81 IL6 PDGFB TGFB1
27 10.8 CRP IL6
28 10.73 MMP9 TGFB1
29 10.72 IL6 MMP9 PDGFB TGFB1
30 10.54 IL6 TGFB1

GO Terms for Diabetic Foot Ulcers

Cellular components related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CRP IL6 MMP9 PDGFB TGFB1
2 extracellular matrix GO:0031012 9.33 MMP9 PDGFB TGFB1
3 platelet alpha granule lumen GO:0031093 9.26 PDGFB TGFB1
4 extracellular region GO:0005576 9.1 CRP IL6 LEPR MMP9 PDGFB TGFB1

Biological processes related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.78 IL6 PDGFB TGFB1
2 inflammatory response GO:0006954 9.76 CRP IL6 TGFB1
3 positive regulation of apoptotic process GO:0043065 9.73 IL6 MMP9 TGFB1
4 positive regulation of MAP kinase activity GO:0043406 9.6 PDGFB TGFB1
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.59 IL6 PDGFB
6 cellular response to growth factor stimulus GO:0071363 9.58 PDGFB TGFB1
7 positive regulation of fibroblast proliferation GO:0048146 9.57 PDGFB TGFB1
8 negative regulation of fat cell differentiation GO:0045599 9.55 IL6 TGFB1
9 positive regulation of cell division GO:0051781 9.54 PDGFB TGFB1
10 positive regulation of cell migration GO:0030335 9.54 MMP9 PDGFB TGFB1
11 monocyte chemotaxis GO:0002548 9.52 IL6 PDGFB
12 T cell differentiation GO:0030217 9.51 LEPR TGFB1
13 acute-phase response GO:0006953 9.49 CRP IL6
14 positive regulation of blood vessel endothelial cell migration GO:0043536 9.48 PDGFB TGFB1
15 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.46 PDGFB TGFB1
16 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.43 PDGFB TGFB1
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.4 MMP9 PDGFB
18 positive regulation of superoxide anion generation GO:0032930 9.32 CRP TGFB1
19 positive regulation of chemotaxis GO:0050921 9.26 PDGFB TGFB1
20 positive regulation of gene expression GO:0010628 9.26 CRP IL6 PDGFB TGFB1
21 negative regulation of lipid storage GO:0010888 9.16 CRP IL6
22 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.8 IL6 PDGFB TGFB1

Molecular functions related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen binding GO:0005518 9.16 MMP9 PDGFB
2 growth factor activity GO:0008083 9.13 IL6 PDGFB TGFB1
3 identical protein binding GO:0042802 9.02 CRP LEPR MMP9 PDGFB TGFB1

Sources for Diabetic Foot Ulcers

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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