MCID: DBT062
MIFTS: 56

Diabetic Foot Ulcers malady

Summaries for Diabetic Foot Ulcers

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

MalaCards: Diabetic Foot Ulcers is related to osteomyelitis and ischemia. An important gene associated with Diabetic Foot Ulcers is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are TOB in T-Cell Signaling and NF-KappaB Family Pathway. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Aliases & Classifications for Diabetic Foot Ulcers

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30LifeMap Discovery™, 44Novoseek
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Aliases & Descriptions:

diabetic foot ulcers 30 44


Related Diseases for Diabetic Foot Ulcers

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1osteomyelitis30.7CRP
2ischemia30.5PDGFB, FGF2, GJA1, NOS3, TGFBR1, TGFB2
3neuropathy30.4CALCA, TTR
4pneumonia30.4CSF3, CRP, TGFB2
5hypertrophic scars30.1FGF2, KRT16, TGFBR2, TGFB3
6diabetes mellitus30.1CALCA, CRP, MMP9, NOS3
7vascular disease30.1PDGFB, CRP, FGF2, MMP9, NOS3, TGFBR1
8melanoma30.1HSPA1B, PDGFB, FGF2, IL15, MMP9, GJA1
9critical limb ischemia10.4
10arthropathy10.3
11diabetic neuropathy10.3
12peripheral vascular disease10.1
13amelanotic melanoma10.1
14hyperglycemia10.1
15kidney disease10.1
16lymphedema10.1
17peripheral neuropathy10.1
18retinitis10.1
19scleritis10.1
20tetanus10.1
21sarcoma10.0PDGFB
22nephritis10.0PDGFB
23dilated cardiomyopathy10.0GJA1
24infertility10.0TGFB2
25thyroiditis10.0CALCA
26hereditary hemorrhagic telangiectasia10.0TGFBR1
27dermatitis10.0KRT16
28medulloblastoma10.0PDGFB
29endometriosis10.0IL15
30gallbladder cancer10.0TGFBR2
31pancreatitis10.0CRP
32hypercalcemia10.0CALCA
33celiac disease10.0IL15
34myeloid leukemia10.0CSF3
35giant cell tumor10.0CALCA
36anorexia nervosa10.0TTR
37hyperparathyroidism10.0CALCA
38migraine10.0CALCA
39essential hypertension10.0NOS3
40laryngeal squamous cell carcinoma10.0TGFBR2
41multiple myeloma10.0CSF3
42ulcerative colitis10.0CRP
43acute leukemia10.0CSF3
44crohn's disease10.0CRP
45polycystic ovary syndrome10.0CRP
46psoriatic arthritis10.0CRP
47pyelonephritis10.0CRP
48bullous keratopathy10.0TGFB2
49lupus erythematosus10.0F2
50myelodysplastic syndromes10.0CSF3

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to diabetic foot ulcers

Clinical Features for Diabetic Foot Ulcers

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Drugs & Therapeutics for Diabetic Foot Ulcers

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Foot Ulcers

Drug clinical trials:

Search ClinicalTrials for Diabetic Foot Ulcers

Search NIH Clinical Center for Diabetic Foot Ulcers

Search CenterWatch for Diabetic Foot Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Foot Ulcers cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Foot Ulcers

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Anatomical Context for Diabetic Foot Ulcers

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Diabetic Foot Ulcers:

32
Skin, Bone, Bone marrow, Colon, Endothelial, Testes, Heart, Kidney

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Diabetic Foot Ulcers or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2PDGFB, TGFB2
2MP:00053779.8KRT10, GJA1
3MP:00036319.8F2, GJA1, PDGFB, HSPA1B
4MP:00053899.7EGF, IL15, MMP9, TGFB2
5MP:00053809.6PDGFB, GJA1, F2, TGFBR2, TGFB3, TGFB2
6MP:00053909.5FGF2, GJA1, NOS3, TGFB3, TGFBR1, TGFB2
7MP:00053829.4KRT16, KRT10, TGFBR2, TGFB3, TGFB2, GJA1
8MP:00053919.4PDGFB, EGF, FGF2, GJA1, TTR, TGFB3
9MP:00053889.4MMP9, GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
10MP:00020069.4CALCA, MMP9, KRT10, TGFBR2, TGFBR1
11MP:00107719.4CALCA, PDGFB, MMP9, GJA1, F2, KRT16
12MP:00053699.1PDGFB, FGF2, MMP9, GJA1, NOS3, TGFBR2
13MP:00053819.0EGF, MMP9, F2, KRT16, NOS3, TGFBR2
14MP:00053768.8CALCA, PDGFB, CRP, GJA1, F2, TTR
15MP:00028738.8CALCA, EGF, GJA1, F2, NOS3, TGFBR2
16MP:00053858.4TGFB2, HSPA1B, CALCA, PDGFB, CRP, IL15
17MP:00053978.2PDGFB, CSF3, FGF2, IL15, MMP9, GJA1
18MP:00053788.0HSPA1B, PDGFB, EGF, IL15, MMP9, GJA1
19MP:00053847.9HSPA1B, FGF2, IL15, MMP9, GJA1, F2
20MP:00053877.6IL15, EGF, CRP, CSF3, PDGFB, HSPA1B
21MP:00107687.6MMP9, IL15, FGF2, PDGFB, CALCA, HSPA1B

Publications for Diabetic Foot Ulcers

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50PubMed
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Articles related to Diabetic Foot Ulcers:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
Hydrocolloid dressings for healing diabetic foot ulcers. (23922167)
2013
2
Understanding diabetic foot ulcers. (24002373)
2013
3
Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. (24358275)
2013
4
Electrophysical therapy for managing diabetic foot ulcers: a systematic review. (22958779)
2013
5
Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients. (23936790)
2013
6
Detection of Escherichia coli and associated I^-lactamases genes from diabetic foot ulcers by multiplex PCR and molecular modeling and docking of SHV-1, TEM-1, and OXA-1 I^-lactamases with clindamycin and piperacillin-tazobactam. (23861873)
2013
7
Nutritional status deteriorates as the severity of diabetic foot ulcers increases and independently associates with prognosis. (23251271)
2013
8
Analysis of transfer lesions in patients who underwent surgery for diabetic foot ulcers located on the plantar aspect of the metatarsal heads. (23600614)
2013
9
Hyperbaric oxygen therapy as adjunctive treatment for diabetic foot ulcers. (23667103)
2013
10
Epidermal growth factor in the treatment of diabetic foot ulcers: an update. (22494968)
2012
11
Dermal substitute template use in diabetic foot ulcers: case reports. (22665922)
2012
12
Plectranthus amboinicus and Centella asiatica Cream for the Treatment of Diabetic Foot Ulcers. (22693530)
2012
13
Prospective randomized controlled study of a Chinese herbal medicine compound Tangzu Yuyang Ointment for chronic diabetic foot ulcers: a preliminary report. (21129474)
2011
14
The economic value of specialized lower-extremity medical care by podiatric physicians in the treatment of diabetic foot ulcers. (21406693)
2011
15
Flexible and rigid casting tape as a novel approach to offloading diabetic foot ulcers. (21841722)
2011
16
A parallel open-label trial to evaluate microbial cellulose wound dressing in the treatment of diabetic foot ulcers. (21159127)
2011
17
i>?i>?i>?i>?i>?i>?i>?Health-related quality of life and self-esteem in patients with diabetic foot ulcers: results of a cross-sectional comparative study. (21422482)
2011
18
Treatment of diabetic foot ulcers: a comparative study of extracorporeal shockwave therapy and hyperbaric oxygen therapy. (21310502)
2011
19
Assessment and management of diabetic foot ulcers. (22067465)
2011
20
Enhanced healing of diabetic foot ulcers using local heat and electrical stimulation for 30 min three times per week. (20923474)
2010
21
Advanced biological therapies for diabetic foot ulcers. (20713816)
2010
22
Preliminary development of a diabetic foot ulcer database from a wound electronic medical record: a tool to decrease limb amputations. (19769719)
2009
23
Presentation and outcome of diabetic foot ulcers in Saudi Arabian patients. (19247012)
2009
24
Maggot debridement therapy with Lucilia cuprina: a comparison with conventional debridement in diabetic foot ulcers. (19291114)
2009
25
A review of the literature on topical therapies for diabetic foot ulcers. Part 2: Advanced treatments. (19862873)
2009
26
Comments on the use of bemiparin in diabetic foot ulcers. (19125772)
2009
27
Virulence potential of Staphylococcus aureus strains isolated from diabetic foot ulcers: a new paradigm. (18809632)
2008
28
The value of debridement and Vacuum-Assisted Closure (V.A.C.) Therapy in diabetic foot ulcers. (18393328)
2008
29
Intermittent intravenous urokinase for critical limb ischemia in diabetic foot ulceration. (18766265)
2008
30
Resource utilisation and costs associated with the treatment of diabetic foot ulcers. Prospective data from the Eurodiale Study. (18648766)
2008
31
Treatment of diabetic foot ulcers in the home: video consultations as an alternative to outpatient hospital care. (18369408)
2008
32
Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream. (18990064)
2008
33
Double blind, randomized, placebo controlled clinical trial for the treatment of diabetic foot ulcers, using a nitric oxide releasing patch: PATHON. (17897470)
2007
34
Methicillin-resistant Staphylococcus aureus (MRSA) isolation from diabetic foot ulcers correlates with nasal MRSA carriage. (16963148)
2007
35
Best practice recommendations for the prevention, diagnosis, and treatment of diabetic foot ulcers: update 2006. (18091117)
2007
36
Assessing the outcome of the management of diabetic foot ulcers using ulcer-related and person-related measures. (16873780)
2006
37
Early change in wound area as a predictor of healing in diabetic foot ulcers: knowing "when to say when". (16799392)
2006
38
A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers. (16595081)
2006
39
Emerging drugs for diabetic foot ulcers. (17064227)
2006
40
Telemedical treatment at home of diabetic foot ulcers. (16375785)
2005
41
A randomized trial of two irremovable off-loading devices in the management of plantar neuropathic diabetic foot ulcers. (15735187)
2005
42
Does close glycaemic control promote healing in diabetic foot ulcers? Report of a feasibility study. (16026373)
2005
43
The role of the nurse specialist in the care of patients with diabetic foot ulcers. (15680114)
2005
44
Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases. (15505764)
2004
45
Infections in diabetic foot ulcers. (13678763)
2003
46
Bilayered bioengineered skin substitute (Apligraf): a review of its use in the treatment of venous leg ulcers and diabetic foot ulcers. (12463767)
2002
47
Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. (12060054)
2002
48
Cost-effective management of recalcitrant diabetic foot ulcers. (12471856)
2002
49
Diabetic foot ulcers: old problems--new technologies. (11274260)
2001
50
Diabetic autonomic neuropathy and foot ulceration. (1308509)
1992

Genetic Variations for Diabetic Foot Ulcers

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Expression for genes affiliated with Diabetic Foot Ulcers

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Foot Ulcers

Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for genes affiliated with Diabetic Foot Ulcers

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TGFB3
2
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10.2PDGFB, TGFB3
3
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10.1TGFB3, TGFBR1
4
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10.1TGFB3, TGFBR1
510.1TGFB3, TGFBR1
6
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10.1TGFBR1, TGFBR2
7
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10.1TGFBR2, TGFBR1
810.1TGFBR2, TGFBR1
9
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10.1TGFBR2, TGFBR1
10
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10.1TGFBR1, TGFBR2
11
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10.1PDGFB, F2
12
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10.0PDGFB, TGFB3, TGFBR1
13
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10.0NOS3, F2
149.9TGFBR2, TGFB3, TGFBR1
159.9TGFBR2, TGFB3, TGFBR1
169.9TGFBR1, TGFB3, TGFBR2
179.9TGFBR1, TGFB3, TGFBR2
189.9TGFBR1, TGFB3, TGFBR2
199.9TGFBR1, TGFB3, TGFBR2
209.9TGFBR1, TGFB3, TGFBR2
219.9MMP9, FGF2
229.9EGF, TGFBR2, TGFBR1
23
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9.9F2, EGF, PDGFB
249.8HSPA1L, HSPA1B, TGFBR1
259.8MMP9, GJA1, NOS3
26
CFTR folding and maturation (norm and CF)
9.8NOS3, HSPA1B, HSPA1L
27
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9.8TGFB2, TGFB3, EGF, PDGFB
289.7TGFBR2, TGFB3, TGFBR1, TGFB2
29
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9.7TGFBR2, TGFB3, TGFBR1, TGFB2
30
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9.7TGFBR2, TGFB3, TGFBR1, TGFB2
31
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9.7EGF, TGFBR2, TGFB3, TGFBR1
32
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9.7TGFB3, TTR, FGF2, PDGFB
339.6TGFBR1, TGFBR2, IL15, PDGFB
34
Development PDGF signaling via STATs and NF-kB
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9.6PDGFB, FGF2, F2, NOS3
359.5NOS3, MMP9, FGF2, PDGFB
36
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9.5TGFBR1, TGFB3, FGF2, EGF, PDGFB
37
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9.3TGFBR1, TGFB3, TGFBR2, PDGFB, HSPA1B, HSPA1L
38
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9.3PDGFB, FGF2, MMP9, F2, TTR
39
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9.3PDGFB, FGF2, NOS3, TGFBR2, TGFB3, TGFBR1
409.2PDGFB, CSF3, EGF, FGF2, NOS3
41
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9.2PDGFB, EGF, FGF2, NOS3, TGFB3, TGFB2
429.2PDGFB, EGF, FGF2, MMP9, TGFBR2, TGFBR1
439.2FGF2, MMP9, NOS3, TGFB3, TGFBR1, TGFB2
44
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9.1PDGFB, CSF3, IL15, TGFBR2, TGFB3, TGFBR1
459.1HSPA1L, HSPA1B, EGF, TGFBR2, TGFB3, TGFBR1
46
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9.0PDGFB, EGF, FGF2, MMP9, TGFB3, TGFBR1
47
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9.0PDGFB, CRP, EGF, FGF2, NOS3, TGFBR2
48
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9.0PDGFB, EGF, FGF2, IL15, TGFBR2, TGFB3
49
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8.9HSPA1B, PDGFB, CSF3, EGF, IL15, TGFBR2
50
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8.6NOS3, IL15, FGF2, EGF, CSF3, PDGFB

Compounds for genes affiliated with Diabetic Foot Ulcers

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7TTR
2pge24410.6MMP9
3cycloheximide4410.6PDGFB, GJA1
4tamoxifen44 49 28 1113.4TGFBR2, GJA1
5hydrocortisone44 2 59 1113.3FGF2, CALCA
6dithranol4410.1EGF, KRT16, KRT10
7p0054410.1IL15, TGFBR2, TGFB2
8trapidil4410.0EGF, FGF2, MMP9
9polyglycolic acid4410.0TGFB3, FGF2, PDGFB
10vitamin a44 11 2412.0FGF2, MMP9, KRT16, TGFB2
111,25 dihydroxy vitamin d3449.9CALCA, GJA1, KRT16, KRT10, TGFB2
12rantes449.8IL15, CSF3
13fluvastatin44 49 28 1112.7NOS3, GJA1, MMP9, CRP
14homocysteine44 2410.7NOS3, TTR, F2, GJA1, CRP
15serine449.7PDGFB, FGF2, MMP9, GJA1, KRT16, TGFBR1
16dihydrotestosterone44 28 11 2412.7EGF, FGF2, TGFBR2, TGFBR1, TGFB2
17creatinine449.7TGFB2, TTR, F2, MMP9, CRP
18bleomycin44 1110.7PDGFB, CSF3, FGF2, MMP9, TGFBR2
19agar449.6PDGFB, EGF, FGF2, GJA1, TTR, TGFB2
20matrigel449.6EGF, IL15, GJA1, NOS3, TGFBR1, TGFB2
21vitamin d449.6CALCA, TTR, KRT10, NOS3, TGFBR2, TGFB2
22methylcellulose449.5KRT10, IL15, FGF2, EGF, CSF3
23hyaluronic acid44 2410.5FGF2, MMP9, F2, TTR, TGFB2
24bromodeoxyuridine449.4PDGFB, EGF, FGF2, IL15, GJA1, KRT10
25sb 20358044 5910.4CRP, EGF, FGF2, MMP9, GJA1, NOS3
26pd 98,059449.4NOS3, GJA1, MMP9, FGF2, EGF, PDGFB
27ascorbic acid44 2410.3TGFB2, NOS3, TTR, FGF2, CRP
28cyclophosphamide44 49 1111.3NOS3, MMP9, IL15, CRP, CSF3
295fluorouracil449.3CSF3, EGF, IL15, TGFB3, TGFB2
30nitric oxide44 11 2411.3CALCA, PDGFB, IL15, GJA1, KRT16, NOS3
31ribonucleic acid449.3PDGFB, IL15, MMP9, GJA1, TGFBR2, TGFB3
32calcitriol44 59 11 2412.3CALCA, EGF, FGF2, GJA1, F2, KRT16
33steroid449.2EGF, IL15, KRT16, KRT10, TGFB3, TGFBR1
34testosterone44 59 11 2412.2CALCA, CRP, EGF, MMP9, GJA1, TTR
35methotrexate44 49 1111.2CSF3, CRP, IL15, MMP9, F2, NOS3
36adenylate449.2CALCA, EGF, IL15, MMP9, GJA1, TTR
37epinephrine44 11 2411.2CALCA, CSF3, F2, TTR
38progesterone44 59 28 11 2413.1PDGFB, EGF, IL15, GJA1, KRT10, TGFBR2
39genistein44 28 59 2 11 2414.1EGF, FGF2, MMP9, GJA1, TTR, NOS3
40ly294002449.1CRP, EGF, FGF2, MMP9, GJA1, NOS3
41thymidine44 2410.0PDGFB, CSF3, EGF, FGF2, IL15, GJA1
42dexamethasone44 49 28 1112.0PDGFB, TGFB2, TGFBR1, TGFB3, TGFBR2, GJA1
43paraffin449.0PDGFB, FGF2, MMP9, GJA1, TTR, KRT16
44tgf beta1449.0PDGFB, EGF, FGF2, IL15, MMP9, TGFBR2
45tyrosine448.8CSF3, EGF, IL15, GJA1, KRT10, TGFBR2
46cyclosporin a44 28 5910.8CALCA, PDGFB, CSF3, FGF2, IL15, F2
47alanine448.8CRP, FGF2, IL15, MMP9, GJA1, F2
48phosphatidylinositol448.7EGF, FGF2, IL15, MMP9, GJA1, NOS3
49retinoic acid44 248.8KRT16, KRT10, NOS3, TGFBR2, TGFB3, TGFBR1
50vegf447.8GJA1, MMP9, IL15, FGF2, EGF, CRP

GO Terms for genes affiliated with Diabetic Foot Ulcers

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16Gene Ontology
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Cellular components related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:07002210.1TGFBR1, TGFBR2
2platelet alpha granule lumenGO:0310939.5PDGFB, EGF, TGFB3, TGFB2
3extracellular regionGO:0055767.9EGF, CRP, PDGFB, CALCA, FGF2, IL15
4extracellular spaceGO:0056157.6TGFB2, CALCA, PDGFB, CSF3, CRP, EGF

Biological processes related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:00018610.5FGF2
2positive regulation of hyaluronan biosynthetic processGO:190012710.5PDGFB, EGF
3menstrual cycle phaseGO:02260110.4TGFB3, TGFB2
4negative regulation of macrophage cytokine productionGO:01093610.4TGFB3, TGFB2
5salivary gland morphogenesisGO:00743510.3TGFB2, TGFB3
6positive regulation of cerebellar granule cell precursor proliferationGO:02194010.3EGF, FGF2
7pathway-restricted SMAD protein phosphorylationGO:06038910.3TGFB2, TGFBR1, TGFBR2
8lens development in camera-type eyeGO:00208810.3GJA1, TGFBR2, TGFBR1
9response to cholesterolGO:07072310.3TGFBR1, TGFBR2
10cell growthGO:01604910.3PDGFB, TGFB3, TGFB2
11positive regulation of reactive oxygen species metabolic processGO:200037910.2TGFBR2, F2, PDGFB
12negative regulation of platelet activationGO:01054410.2NOS3, F2, PDGFB
13endothelial cell migrationGO:04354210.2TGFBR1, NOS3, CALCA
14peptidyl-serine phosphorylationGO:01810510.2TGFBR1, TGFBR2, PDGFB
15palate developmentGO:06002110.2TGFBR2, TGFB3, TGFBR1
16response to woundingGO:00961110.2PDGFB, F2, TGFB2
17positive regulation of immune responseGO:05077810.2TGFB2, IL15
18activation of protein kinase activityGO:03214710.2TGFB2, TGFBR2, PDGFB, CALCA
19embryo implantationGO:00756610.2TGFBR2, MMP9, CALCA
20platelet degranulationGO:00257610.1TGFB2, TGFB3, EGF, PDGFB
21SMAD protein import into nucleusGO:00718410.1TGFB3, TGFB2
22positive regulation of cell divisionGO:05178110.1PDGFB, FGF2, TGFB3, TGFB2
23negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.1TGFBR2, TGFB3, TGFBR1
24positive regulation of ossificationGO:04577810.1TGFB2, CALCA
25response to hypoxiaGO:00166610.1PDGFB, CRP, TGFB3, TGFB2
26transforming growth factor beta receptor signaling pathwayGO:00717910.0PDGFB, TGFBR2, TGFB3, TGFBR1, TGFB2
27heart developmentGO:00750710.0PDGFB, GJA1, TGFBR2, TGFBR1, TGFB2
28positive regulation of cell growthGO:03030710.0TGFB2, TGFBR1, F2
29positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.0TGFB2, F2, CSF3, PDGFB
30angiogenesisGO:0015259.9EGF, NOS3, TGFBR1, TGFB2
31in utero embryonic developmentGO:0017019.9GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
32protein phosphorylationGO:0064689.9TGFB2, TGFBR1, TGFBR2, PDGFB, CALCA
33platelet activationGO:0301689.9PDGFB, EGF, F2, TGFB3, TGFB2
34wound healingGO:0420609.8CRP, FGF2, TGFBR2, TGFBR1, TGFB2
35positive regulation of SMAD protein import into nucleusGO:0603919.8TGFBR1, TGFB3
36agingGO:0075689.8CALCA, CRP, IL15, TGFBR2, TGFB3
37extracellular matrix organizationGO:0301989.6PDGFB, FGF2, MMP9, TTR, TGFB3, TGFB2
38blood coagulationGO:0075969.6PDGFB, EGF, F2, NOS3, TGFB3, TGFB2
39positive regulation of transcription, DNA-dependentGO:0458939.5PDGFB, EGF, FGF2, TGFB3, TGFBR1
40negative regulation of cell proliferationGO:0082859.5HSPA1B, FGF2, GJA1, NOS3, TGFB3, TGFB2
41cell-cell signalingGO:0072679.5TGFB2, GJA1, IL15, CALCA
42positive regulation of cell proliferationGO:0082848.8TGFB2, PDGFB, CSF3, EGF, FGF2, IL15

Molecular functions related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:03471310.1TGFB3, TGFBR2
2type II transforming growth factor beta receptor bindingGO:00511410.1TGFB3, TGFBR1, TGFB2
3transforming growth factor beta bindingGO:05043110.0TGFBR1, TGFB3, TGFBR2
4transmembrane receptor protein serine/threonine kinase activityGO:00467510.0TGFBR1, TGFBR2
5receptor signaling protein serine/threonine kinase activityGO:0047029.8TGFBR2, TGFB2
6receptor bindingGO:0051029.7TGFB2, F2, GJA1, CALCA
7cytokine activityGO:0051259.4CSF3, FGF2, IL15, TGFB2
8growth factor activityGO:0080839.1TGFB2, PDGFB, CSF3, EGF, FGF2, F2
9protein bindingGO:0055156.9IL15, FGF2, EGF, CRP, PDGFB, CALCA

Products for genes affiliated with Diabetic Foot Ulcers

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Diabetic Foot Ulcers

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet