MCID: DBT062
MIFTS: 56

Diabetic Foot Ulcers malady

Summaries for Diabetic Foot Ulcers

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

MalaCards: Diabetic Foot Ulcers is related to osteomyelitis and ischemia. An important gene associated with Diabetic Foot Ulcers is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are TOB in T-Cell Signaling and NF-KappaB Family Pathway. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Aliases & Classifications for Diabetic Foot Ulcers

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30LifeMap Discovery™, 44Novoseek
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Aliases & Descriptions:

diabetic foot ulcers 30 44


Related Diseases for Diabetic Foot Ulcers

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1osteomyelitis30.7CRP
2ischemia30.5PDGFB, FGF2, GJA1, NOS3, TGFBR1, TGFB2
3neuropathy30.4CALCA, TTR
4pneumonia30.4CSF3, CRP, TGFB2
5hypertrophic scars30.1FGF2, KRT16, TGFBR2, TGFB3
6diabetes mellitus30.1CALCA, CRP, MMP9, NOS3
7vascular disease30.1PDGFB, CRP, FGF2, MMP9, NOS3, TGFBR1
8melanoma30.1HSPA1B, PDGFB, FGF2, IL15, MMP9, GJA1
9critical limb ischemia10.4
10arthropathy10.3
11diabetic neuropathy10.3
12peripheral vascular disease10.1
13amelanotic melanoma10.1
14hyperglycemia10.1
15kidney disease10.1
16lymphedema10.1
17peripheral neuropathy10.1
18retinitis10.1
19scleritis10.1
20tetanus10.1
21sarcoma10.0PDGFB
22nephritis10.0PDGFB
23dilated cardiomyopathy10.0GJA1
24infertility10.0TGFB2
25thyroiditis10.0CALCA
26hereditary hemorrhagic telangiectasia10.0TGFBR1
27dermatitis10.0KRT16
28medulloblastoma10.0PDGFB
29endometriosis10.0IL15
30gallbladder cancer10.0TGFBR2
31pancreatitis10.0CRP
32hypercalcemia10.0CALCA
33celiac disease10.0IL15
34myeloid leukemia10.0CSF3
35giant cell tumor10.0CALCA
36anorexia nervosa10.0TTR
37hyperparathyroidism10.0CALCA
38migraine10.0CALCA
39essential hypertension10.0NOS3
40laryngeal squamous cell carcinoma10.0TGFBR2
41multiple myeloma10.0CSF3
42ulcerative colitis10.0CRP
43acute leukemia10.0CSF3
44crohn's disease10.0CRP
45polycystic ovary syndrome10.0CRP
46psoriatic arthritis10.0CRP
47pyelonephritis10.0CRP
48bullous keratopathy10.0TGFB2
49lupus erythematosus10.0F2
50myelodysplastic syndromes10.0CSF3

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to diabetic foot ulcers

Clinical Features for Diabetic Foot Ulcers

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Drugs & Therapeutics for Diabetic Foot Ulcers

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Foot Ulcers

Drug clinical trials:

Search ClinicalTrials for Diabetic Foot Ulcers

Search NIH Clinical Center for Diabetic Foot Ulcers

Search CenterWatch for Diabetic Foot Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Foot Ulcers cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Foot Ulcers

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Anatomical Context for Diabetic Foot Ulcers

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Diabetic Foot Ulcers:

32
Skin, Bone, Bone marrow, Colon, Endothelial, Testes, Heart, Kidney

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Diabetic Foot Ulcers or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2PDGFB, TGFB2
2MP:00053779.8KRT10, GJA1
3MP:00036319.8F2, GJA1, PDGFB, HSPA1B
4MP:00053899.7EGF, IL15, MMP9, TGFB2
5MP:00053809.6PDGFB, GJA1, F2, TGFBR2, TGFB3, TGFB2
6MP:00053909.5FGF2, GJA1, NOS3, TGFB3, TGFBR1, TGFB2
7MP:00053829.4KRT16, KRT10, TGFBR2, TGFB3, TGFB2, GJA1
8MP:00053919.4PDGFB, EGF, FGF2, GJA1, TTR, TGFB3
9MP:00053889.4MMP9, GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
10MP:00020069.4CALCA, MMP9, KRT10, TGFBR2, TGFBR1
11MP:00107719.4CALCA, PDGFB, MMP9, GJA1, F2, KRT16
12MP:00053699.1PDGFB, FGF2, MMP9, GJA1, NOS3, TGFBR2
13MP:00053819.0EGF, MMP9, F2, KRT16, NOS3, TGFBR2
14MP:00053768.8CALCA, PDGFB, CRP, GJA1, F2, TTR
15MP:00028738.8CALCA, EGF, GJA1, F2, NOS3, TGFBR2
16MP:00053858.4TGFB2, HSPA1B, CALCA, PDGFB, CRP, IL15
17MP:00053978.2PDGFB, CSF3, FGF2, IL15, MMP9, GJA1
18MP:00053788.0HSPA1B, PDGFB, EGF, IL15, MMP9, GJA1
19MP:00053847.9HSPA1B, FGF2, IL15, MMP9, GJA1, F2
20MP:00053877.6IL15, EGF, CRP, CSF3, PDGFB, HSPA1B
21MP:00107687.6MMP9, IL15, FGF2, PDGFB, CALCA, HSPA1B

Publications for Diabetic Foot Ulcers

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50PubMed
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Articles related to Diabetic Foot Ulcers:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers. (23671876)
2013
2
The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. (23566071)
2013
3
Systematic review of the effectiveness of hyperbaric oxygenation therapy in the management of chronic diabetic foot ulcers. (23374620)
2013
4
Assessing outcome of diabetic foot ulcers and multidisciplinary foot clinic. (23865411)
2013
5
Alginate dressings for healing diabetic foot ulcers. (23799857)
2013
6
A prospective, non comparative, multicenter study to investigate the effect of cadexomer iodine on bioburden load and other wound characteristics in diabetic foot ulcers. (23136838)
2013
7
TOWARDS REACHING THE TARGET: CLINICAL APPLICATION OF MESENCHYMAL STEM CELL (MSC) FOR DIABETIC FOOT ULCERS (DFUS). (24237303)
2013
8
Phase IIa randomized, placebo-controlled study of antimicrobial photodynamic therapy in bacterially colonized, chronic leg ulcers and diabetic foot ulcers: a new approach to antimicrobial therapy. (23066973)
2013
9
Treatment of diabetic foot ulcers using cultured allogeneic keratinocytes--a pilot study. (22672334)
2012
10
From ulcer to infection: an update on clinical practice and adjunctive treatments of diabetic foot ulcers. (22903847)
2012
11
Volume Measures Using a Digital Image Analysis System are Reliable in Diabetic Foot Ulcers. (24058274)
2012
12
Neuropathic diabetic foot ulcers - evidence-to-practice. (22371655)
2012
13
Foam dressings for healing diabetic foot ulcers. (21901731)
2011
14
Economic Burden of Diabetic Foot Ulcers and Amputations: Data Points #3 (22049568)
2011
15
The effect of topical phenytoin on healing in diabetic foot ulcers: a randomized controlled trial. (21480976)
2011
16
Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial. (21216483)
2011
17
The use of superoxidized aqueous solution versus saline as a replacement solution in the versajet lavage system in chronic diabetic foot ulcers: a pilot study. (21406695)
2011
18
A prospective study of the PUSH tool in diabetic foot ulcers. (21606864)
2011
19
Diabetic foot ulcers treated with becaplermin and TheraGauze, a moisture-controlling smart dressing: a randomized, multicenter, prospective analysis. (20479444)
2010
20
Treatment of diabetic foot ulcers using a blood bank platelet concentrate. (20195121)
2010
21
Outcome of arterial reconstruction and free-flap coverage in diabetic foot ulcers: long-term results. (19823902)
2010
22
The importance of growth factors for the treatment of chronic wounds in the case of diabetic foot ulcers. (21289885)
2010
23
Confirmatory data from EU study supports Apligraf for the treatment of neuropathic diabetic foot ulcers. (20093548)
2010
24
A checklist system to score healing progress of diabetic foot ulcers. (20483806)
2010
25
Current concepts review: diabetic foot ulcers. (20460077)
2010
26
Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment. (19731315)
2009
27
Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. (18387077)
2008
28
Skin replacement therapies for diabetic foot ulcers: systematic review and meta-analysis. (18162495)
2008
29
Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. (18162494)
2008
30
Phase I trial on the safety of topical rhVEGF on chronic neuropathic diabetic foot ulcers. (18210954)
2008
31
History of and factors associated with diabetic foot ulcers in Norway: the Nord-TrA,ndelag Health Study. (18426786)
2008
32
Mortality rates and diabetic foot ulcers: is it time to communicate mortality risk to patients with diabetic foot ulceration? (19017860)
2008
33
An off-the-shelf instant contact casting device for the management of diabetic foot ulcers: a randomized prospective trial versus traditional fiberglass cast. (17327325)
2007
34
Can a wound-based severity score for diabetic foot ulcers predict clinical outcome? (17262069)
2007
35
Bacterial load predicts healing rate in neuropathic diabetic foot ulcers. (17259515)
2007
36
Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. (16799391)
2006
37
The Biogun: A novel way of eradicating methicillin-resistant Staphylococcus aureus colonization in diabetic foot ulcers. (16644661)
2006
38
Honey for refractory diabetic foot ulcers. (16237870)
2005
39
Healing of diabetic foot ulcers in L-arginine-treated patients. (15589068)
2004
40
Safety and performance of a new non-adhesive foam dressing for the treatment of diabetic foot ulcers. (15045807)
2004
41
Clinical practice. Neuropathic diabetic foot ulcers. (15229307)
2004
42
Rapid healing of intractable diabetic foot ulcers with exposed bones following a novel therapy of exposing bone marrow cells and then grafting epidermal sheets. (15541080)
2004
43
A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers. (15853123)
2004
44
Development and validation of the Diabetic Foot Ulcer Scale-short form (DFS-SF). (14986739)
2003
45
Diabetic foot ulcers: principles of assessment and treatment. (11344807)
2001
46
Exploring the use of an alginate dressing for diabetic foot ulcers. (11924357)
2001
47
Outpatient care and morbidity reduction in diabetic foot ulcers associated with chronic pressure callus. (11420344)
2001
48
Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. (10727985)
2000
49
Bacteria in superficial diabetic foot ulcers. (11131109)
2000
50
Lower-extremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers. (10388962)
1999

Genetic Variations for Diabetic Foot Ulcers

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Expression for genes affiliated with Diabetic Foot Ulcers

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Foot Ulcers

Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for genes affiliated with Diabetic Foot Ulcers

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TGFB3
2
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10.2PDGFB, TGFB3
3
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10.1TGFBR1, TGFB3
4
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10.1TGFB3, TGFBR1
510.1TGFBR1, TGFB3
6
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10.1TGFBR1, TGFBR2
7
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10.1TGFBR1, TGFBR2
810.1TGFBR2, TGFBR1
9
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10.1TGFBR1, TGFBR2
10
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10.1TGFBR1, TGFBR2
11
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10.1PDGFB, F2
12
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10.0TGFBR1, TGFB3, PDGFB
13
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10.0NOS3, F2
149.9TGFBR2, TGFBR1, TGFB3
159.9TGFBR1, TGFBR2, TGFB3
169.9TGFBR2, TGFB3, TGFBR1
179.9TGFB3, TGFBR2, TGFBR1
189.9TGFB3, TGFBR2, TGFBR1
199.9TGFB3, TGFBR1, TGFBR2
209.9TGFBR1, TGFB3, TGFBR2
219.9MMP9, FGF2
229.9EGF, TGFBR2, TGFBR1
23
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9.9F2, EGF, PDGFB
249.8TGFBR1, HSPA1L, HSPA1B
259.8NOS3, GJA1, MMP9
26
CFTR folding and maturation (norm and CF)
9.8HSPA1L, HSPA1B, NOS3
27
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9.8PDGFB, EGF, TGFB2, TGFB3
289.7TGFB2, TGFBR1, TGFBR2, TGFB3
29
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9.7TGFB2, TGFBR2, TGFB3, TGFBR1
30
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9.7TGFBR1, TGFB2, TGFB3, TGFBR2
31
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9.7TGFB3, TGFBR1, TGFBR2, EGF
32
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9.7TTR, PDGFB, TGFB3, FGF2
339.6PDGFB, IL15, TGFBR2, TGFBR1
34
Development PDGF signaling via STATs and NF-kB
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9.6PDGFB, NOS3, F2, FGF2
359.5MMP9, PDGFB, FGF2, NOS3
36
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9.5TGFBR1, PDGFB, FGF2, TGFB3, EGF
37
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9.3TGFBR1, HSPA1L, PDGFB, TGFBR2, TGFB3, HSPA1B
38
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9.3F2, PDGFB, MMP9, TTR, FGF2
39
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9.3TGFBR2, NOS3, TGFBR1, PDGFB, TGFB3, FGF2
409.2PDGFB, CSF3, EGF, FGF2, NOS3
41
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9.2FGF2, PDGFB, EGF, NOS3, TGFB3, TGFB2
429.2MMP9, FGF2, PDGFB, TGFBR1, EGF, TGFBR2
439.2NOS3, FGF2, MMP9, TGFB3, TGFBR1, TGFB2
44
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9.1PDGFB, CSF3, IL15, TGFBR2, TGFBR1, TGFB3
459.1HSPA1L, EGF, TGFBR2, TGFB3, TGFBR1, HSPA1B
46
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9.0PDGFB, FGF2, MMP9, TGFB3, TGFBR1, TGFB2
47
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9.0FGF2, TGFBR1, TGFBR2, NOS3, PDGFB, CRP
48
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9.0PDGFB, TGFBR2, EGF, FGF2, IL15, TGFBR1
49
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8.9EGF, PDGFB, HSPA1B, IL15, CSF3, TGFBR2
50
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8.6NOS3, FGF2, PDGFB, IL15, TGFB3, CSF3

Compounds for genes affiliated with Diabetic Foot Ulcers

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7TTR
2pge24410.6MMP9
3cycloheximide4410.6PDGFB, GJA1
4tamoxifen44 49 28 1113.4TGFBR2, GJA1
5hydrocortisone44 2 59 1113.3FGF2, CALCA
6dithranol4410.1KRT16, KRT10, EGF
7p0054410.1TGFB2, IL15, TGFBR2
8trapidil4410.0FGF2, EGF, MMP9
9polyglycolic acid4410.0PDGFB, FGF2, TGFB3
10vitamin a44 11 2412.0TGFB2, KRT16, MMP9, FGF2
111,25 dihydroxy vitamin d3449.9KRT16, GJA1, CALCA, TGFB2, KRT10
12rantes449.8IL15, CSF3
13fluvastatin44 49 28 1112.7GJA1, CRP, NOS3, MMP9
14homocysteine44 2410.7TTR, F2, GJA1, CRP, NOS3
15serine449.7MMP9, PDGFB, GJA1, KRT16, TGFBR1, FGF2
16dihydrotestosterone44 28 11 2412.7TGFBR1, FGF2, TGFBR2, TGFB2, EGF
17creatinine449.7TGFB2, MMP9, F2, TTR, CRP
18bleomycin44 1110.7PDGFB, CSF3, FGF2, MMP9, TGFBR2
19agar449.6FGF2, GJA1, PDGFB, TGFB2, EGF, TTR
20matrigel449.6TGFBR1, EGF, IL15, GJA1, NOS3, TGFB2
21vitamin d449.6TGFBR2, TGFB2, TTR, KRT10, NOS3, CALCA
22methylcellulose449.5IL15, KRT10, EGF, FGF2, CSF3
23hyaluronic acid44 2410.5FGF2, MMP9, TTR, TGFB2, F2
24bromodeoxyuridine449.4FGF2, EGF, PDGFB, GJA1, KRT10, IL15
25sb 20358044 5910.4GJA1, NOS3, CRP, FGF2, EGF, MMP9
26pd 98,059449.4NOS3, GJA1, EGF, PDGFB, FGF2, MMP9
27ascorbic acid44 2410.3FGF2, TGFB2, CRP, NOS3, TTR
28cyclophosphamide44 49 1111.3CRP, IL15, MMP9, NOS3, CSF3
295fluorouracil449.3CSF3, EGF, TGFB3, TGFB2, IL15
30nitric oxide44 11 2411.3NOS3, TGFB3, KRT16, GJA1, IL15, CALCA
31ribonucleic acid449.3TGFB3, TGFBR2, MMP9, TGFBR1, TGFB2, IL15
32calcitriol44 59 11 2412.3TGFB2, KRT10, KRT16, F2, GJA1, FGF2
33steroid449.2IL15, EGF, KRT16, KRT10, TGFB3, TGFB2
34testosterone44 59 11 2412.2TGFB2, CALCA, CRP, EGF, MMP9, GJA1
35methotrexate44 49 1111.2IL15, CSF3, MMP9, F2, CRP, NOS3
36adenylate449.2CALCA, GJA1, EGF, IL15, TTR, TGFBR2
37epinephrine44 11 2411.2CALCA, F2, CSF3, TTR
38progesterone44 59 28 11 2413.1TGFBR2, TGFB3, EGF, IL15, TGFBR1, TGFB2
39genistein44 28 59 2 11 2414.1NOS3, TGFB2, TTR, MMP9, GJA1, TGFBR1
40ly294002449.1CRP, EGF, FGF2, MMP9, GJA1, NOS3
41thymidine44 2410.0FGF2, IL15, TGFB2, TGFB3, PDGFB, CSF3
42dexamethasone44 49 28 1112.0IL15, TGFB2, TGFBR1, TGFB3, TGFBR2, GJA1
43paraffin449.0KRT10, TGFB3, TGFB2, TGFBR1, KRT16, TTR
44tgf beta1449.0PDGFB, EGF, TGFB2, TGFBR1, TGFB3, TGFBR2
45tyrosine448.8GJA1, PDGFB, CSF3, EGF, IL15, TGFB2
46cyclosporin a44 28 5910.8F2, IL15, FGF2, CALCA, CSF3, PDGFB
47alanine448.8TGFBR1, TTR, F2, GJA1, IL15, FGF2
48phosphatidylinositol448.7MMP9, TGFB2, NOS3, GJA1, IL15, FGF2
49retinoic acid44 248.8FGF2, EGF, CSF3, IL15, MMP9, TGFB2
50vegf447.8CALCA, PDGFB, CSF3, CRP, FGF2, IL15

GO Terms for genes affiliated with Diabetic Foot Ulcers

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Sources:
16Gene Ontology
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Cellular components related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:07002210.1TGFBR1, TGFBR2
2platelet alpha granule lumenGO:0310939.5PDGFB, EGF, TGFB3, TGFB2
3extracellular regionGO:0055767.9EGF, CRP, PDGFB, CALCA, FGF2, IL15
4extracellular spaceGO:0056157.6TGFB2, CALCA, PDGFB, CSF3, CRP, EGF

Biological processes related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:00018610.5FGF2
2positive regulation of hyaluronan biosynthetic processGO:190012710.5PDGFB, EGF
3menstrual cycle phaseGO:02260110.4TGFB3, TGFB2
4negative regulation of macrophage cytokine productionGO:01093610.4TGFB3, TGFB2
5salivary gland morphogenesisGO:00743510.3TGFB2, TGFB3
6positive regulation of cerebellar granule cell precursor proliferationGO:02194010.3EGF, FGF2
7pathway-restricted SMAD protein phosphorylationGO:06038910.3TGFB2, TGFBR1, TGFBR2
8lens development in camera-type eyeGO:00208810.3GJA1, TGFBR2, TGFBR1
9response to cholesterolGO:07072310.3TGFBR1, TGFBR2
10cell growthGO:01604910.3PDGFB, TGFB3, TGFB2
11positive regulation of reactive oxygen species metabolic processGO:200037910.2TGFBR2, F2, PDGFB
12negative regulation of platelet activationGO:01054410.2NOS3, F2, PDGFB
13endothelial cell migrationGO:04354210.2TGFBR1, NOS3, CALCA
14peptidyl-serine phosphorylationGO:01810510.2TGFBR1, TGFBR2, PDGFB
15palate developmentGO:06002110.2TGFBR2, TGFB3, TGFBR1
16response to woundingGO:00961110.2PDGFB, F2, TGFB2
17positive regulation of immune responseGO:05077810.2TGFB2, IL15
18activation of protein kinase activityGO:03214710.2TGFB2, TGFBR2, PDGFB, CALCA
19embryo implantationGO:00756610.2TGFBR2, MMP9, CALCA
20platelet degranulationGO:00257610.1TGFB2, TGFB3, EGF, PDGFB
21SMAD protein import into nucleusGO:00718410.1TGFB3, TGFB2
22positive regulation of cell divisionGO:05178110.1PDGFB, FGF2, TGFB3, TGFB2
23negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.1TGFBR2, TGFB3, TGFBR1
24positive regulation of ossificationGO:04577810.1TGFB2, CALCA
25response to hypoxiaGO:00166610.1PDGFB, CRP, TGFB3, TGFB2
26transforming growth factor beta receptor signaling pathwayGO:00717910.0PDGFB, TGFBR2, TGFB3, TGFBR1, TGFB2
27heart developmentGO:00750710.0PDGFB, GJA1, TGFBR2, TGFBR1, TGFB2
28positive regulation of cell growthGO:03030710.0TGFB2, TGFBR1, F2
29positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.0TGFB2, F2, CSF3, PDGFB
30angiogenesisGO:0015259.9EGF, NOS3, TGFBR1, TGFB2
31in utero embryonic developmentGO:0017019.9GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
32protein phosphorylationGO:0064689.9TGFB2, TGFBR1, TGFBR2, PDGFB, CALCA
33platelet activationGO:0301689.9PDGFB, EGF, F2, TGFB3, TGFB2
34wound healingGO:0420609.8CRP, FGF2, TGFBR2, TGFBR1, TGFB2
35positive regulation of SMAD protein import into nucleusGO:0603919.8TGFBR1, TGFB3
36agingGO:0075689.8CALCA, CRP, IL15, TGFBR2, TGFB3
37extracellular matrix organizationGO:0301989.6PDGFB, FGF2, MMP9, TTR, TGFB3, TGFB2
38blood coagulationGO:0075969.6PDGFB, EGF, F2, NOS3, TGFB3, TGFB2
39positive regulation of transcription, DNA-dependentGO:0458939.5PDGFB, EGF, FGF2, TGFB3, TGFBR1
40negative regulation of cell proliferationGO:0082859.5HSPA1B, FGF2, GJA1, NOS3, TGFB3, TGFB2
41cell-cell signalingGO:0072679.5TGFB2, GJA1, IL15, CALCA
42positive regulation of cell proliferationGO:0082848.8TGFB2, PDGFB, CSF3, EGF, FGF2, IL15

Molecular functions related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:03471310.1TGFB3, TGFBR2
2type II transforming growth factor beta receptor bindingGO:00511410.1TGFB3, TGFBR1, TGFB2
3transforming growth factor beta bindingGO:05043110.0TGFBR1, TGFB3, TGFBR2
4transmembrane receptor protein serine/threonine kinase activityGO:00467510.0TGFBR1, TGFBR2
5receptor signaling protein serine/threonine kinase activityGO:0047029.8TGFBR2, TGFB2
6receptor bindingGO:0051029.7TGFB2, F2, GJA1, CALCA
7cytokine activityGO:0051259.4CSF3, FGF2, IL15, TGFB2
8growth factor activityGO:0080839.1TGFB2, PDGFB, CSF3, EGF, FGF2, F2
9protein bindingGO:0055156.9IL15, FGF2, EGF, CRP, PDGFB, CALCA

Products for genes affiliated with Diabetic Foot Ulcers

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  • Antibodies
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Sources for Diabetic Foot Ulcers

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet