MCID: DBT062
MIFTS: 46

Diabetic Foot Ulcers malady

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Summaries for Diabetic Foot Ulcers

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65Wikipedia, 33MalaCards
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Wikipedia:65 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

MalaCards: Diabetic Foot Ulcers is related to hypertrophic scars and melanoma. An important gene associated with Diabetic Foot Ulcers is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Renal cell carcinoma. The compounds dithranol and ttnpb have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are limbs/digits/tail and integument.

Aliases & Classifications for Diabetic Foot Ulcers

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31LifeMap Discovery™, 45Novoseek
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Aliases & Descriptions:

diabetic foot ulcers 31 45


Related Diseases for Diabetic Foot Ulcers

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic scars30.2TGFB3, KRT16
2melanoma30.1GJA1, PDGFB, TGFB3
3blindness10.6
4osteomyelitis10.5
5critical limb ischemia10.4
6ischemia10.4
7endotheliitis10.4
8arthropathy10.3
9neuropathy10.3
10pneumonia10.3
11peripheral vascular disease10.1
12limb ischemia10.1
13peripheral artery disease10.1
14amelanotic melanoma10.1
15artery disease10.1
16diabetes mellitus10.1
17hyperglycemia10.1
18kidney disease10.1
19lymphedema10.1
20peripheral neuropathy10.1
21retinitis10.1
22scleritis10.1
23tetanus10.1
24vascular disease10.1
25klebsiella10.1
26steatocystoma multiplex10.0KRT16, KRT10
27bowen syndrome10.0KRT16, KRT10
28epidermolytic hyperkeratosis10.0KRT16, KRT10
29epidermolysis bullosa simplex10.0KRT16, KRT10
30nonepidermolytic palmoplantar keratoderma10.0KRT16, KRT10
31keratosis10.0KRT10, KRT16
32lichen planus10.0KRT16, KRT10
33cholesteatoma10.0KRT10, KRT16
34papilloma10.0GJA1, KRT10
35basal cell carcinoma10.0KRT10, KRT16
36glioblastoma multiforme10.0PDGFB, GJA1
37rhabdomyosarcoma10.0PDGFB, GJA1
38noonan syndrome10.0GJA1, PDGFB
39pulmonary fibrosis10.0PDGFB, TGFB3
40uterine fibroid10.0GJA1, TGFB3
41leiomyoma10.0TGFB3, GJA1
42palmoplantar keratosis10.0GJA1, KRT16, KRT10
43systemic scleroderma10.0PDGFB, TGFB3
44skin disease10.0GJA1, KRT16, KRT10
45cataract10.0TGFB3, GJA1
46lung benign neoplasm10.0GJA1, PDGFB
47liver cirrhosis10.0PDGFB, TGFB3
48hypertrophy of breast10.0PDGFB, TGFB3, GJA1
49osteosarcoma10.0GJA1, TGFB3, PDGFB
50adenocarcinoma9.9KRT10, TGFB3, PDGFB, GJA1

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to diabetic foot ulcers

Symptoms for Diabetic Foot Ulcers

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Drugs & Therapeutics for Diabetic Foot Ulcers

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Genetic Tests for Diabetic Foot Ulcers

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Anatomical Context for Diabetic Foot Ulcers

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31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Diabetic Foot Ulcers:

33
Skin, Bone, Bone marrow, Colon, Testes, Endothelial, Kidney, Heart

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Diabetic Foot Ulcers or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7KRT10, GJA1, TGFB3
2MP:00107718.5PDGFB, GJA1, KRT10, KRT16
3MP:00053828.2KRT16, KRT10, GJA1, TGFB3
4MP:00107687.4TGFB3, PDGFB, GJA1, KRT10, KRT16

Publications for Diabetic Foot Ulcers

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52PubMed
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Articles related to Diabetic Foot Ulcers:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers. (23671876)
2013
2
Diabetic foot ulcer microbiome: one small step for molecular microbiology . . . One giant leap for understanding diabetic foot ulcers? (23431007)
2013
3
Hydrocolloid dressings for healing diabetic foot ulcers. (23922167)
2013
4
Increasing incidence of Gram-negative organisms in bacterial agents isolated from diabetic foot ulcers. (24129622)
2013
5
Understanding diabetic foot ulcers. (24002373)
2013
6
Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. (24391454)
2013
7
The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. (23566071)
2013
8
Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. (24358275)
2013
9
Topical honey for diabetic foot ulcers. (23795214)
2013
10
Prevention and management of neuropathic diabetic foot ulcers. (24128251)
2013
11
Increased ratio of serum matrix metalloproteinase-9 against TIMP-1 predicts poor wound healing in diabetic foot ulcers. (23357650)
2013
12
Efficacy of low level laser therapy on wound healing in patients with chronic diabetic foot ulcers-a randomised control trial. (24082586)
2012
13
A pilot study evaluating noncontact low frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers. (23163982)
2012
14
A retrospective study of diabetic foot ulcers treated with hyperbaric oxygen therapy. (22372584)
2012
15
Diffuse near-infrared spectroscopy prediction of healing in diabetic foot ulcers: a human study and cost analysis. (23110417)
2012
16
Systematic review and mixed treatment comparison: dressings to heal diabetic foot ulcers. (22544222)
2012
17
Role of negative pressure wound therapy in healing of diabetic foot ulcers. (22022646)
2011
18
The impact of creatinine clearance on the outcome of diabetic foot ulcers in north Indian tertiary care hospital. (22813563)
2011
19
Foam dressings for healing diabetic foot ulcers. (21901731)
2011
20
Bioengineered skin in diabetic foot ulcers. (20380651)
2010
21
Diabetic foot ulcers treated with becaplermin and TheraGauze, a moisture-controlling smart dressing: a randomized, multicenter, prospective analysis. (20479444)
2010
22
Does cell therapy and tissue engineering represent a promising treatment of diabetic foot ulcers? (20437823)
2010
23
Role of early surgical revascularization in the management of refractory diabetic foot ulcers in patients without overt ischemic limbs. (20152756)
2010
24
Clinical signs of infection in diabetic foot ulcers with high microbial load. (19147524)
2009
25
Clinical effectiveness of an acellular dermal regenerative tissue matrix compared to standard wound management in healing diabetic foot ulcers: a prospective, randomised, multicentre study. (19368581)
2009
26
An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. (19065083)
2008
27
Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers: a 6.5-year follow-up study. (18390801)
2008
28
Wound-related pain is underestimated in patients with diabetic foot ulcers. (18947021)
2008
29
Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. (18387077)
2008
30
Using honey to heal diabetic foot ulcers. (18600072)
2008
31
Virulence potential of Staphylococcus aureus strains isolated from diabetic foot ulcers: a new paradigm. (18809632)
2008
32
Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. (18400121)
2008
33
A comparison of the health-related quality of life in patients with diabetic foot ulcers, with a diabetes group and a nondiabetes group from the general population. (17091370)
2007
34
A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers. (18044080)
2007
35
A feasibility study of UMTS mobile phones for supporting nurses doing home visits to patients with diabetic foot ulcers. (17059653)
2006
36
Diabetic foot ulcers. (16484268)
2006
37
The efficacy of Apligraf in the treatment of diabetic foot ulcers. (16799383)
2006
38
Tetanus prophylaxis for diabetic foot ulcers. (17067894)
2006
39
Telemedical treatment at home of diabetic foot ulcers. (16375785)
2005
40
Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infections. (15659542)
2005
41
Optimal treatment of infected diabetic foot ulcers. (15493949)
2004
42
The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcers. (15562198)
2004
43
Healing of diabetic foot ulcers in L-arginine-treated patients. (15589068)
2004
44
Diabetic foot ulcers. (12737879)
2003
45
Growth factors in the treatment of diabetic foot ulcers. (12555288)
2003
46
A comparison of plantar pressure in patients with diabetic foot ulcers using different hosiery. (15871969)
2002
47
Applied felted foam for plantar pressure relief is an efficient therapy in neuropathic diabetic foot ulcers. (12397530)
2002
48
Effects of felted foam on plantar pressures in the treatment of neuropathic diabetic foot ulcers. (11723100)
2001
49
Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. (10727985)
2000
50
Diabetic foot ulcers. A guide to treatment. (11702311)
2000

Variations for Diabetic Foot Ulcers

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Expression for genes affiliated with Diabetic Foot Ulcers

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Foot Ulcers

Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for genes affiliated with Diabetic Foot Ulcers

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50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2PDGFB, TGFB3
29.2PDGFB, TGFB3
3
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.1GJA1, TGFB3
4
Show member pathways
MAPK signaling pathway38
8.6PDGFB, TGFB3, HSPA1L

Compounds for genes affiliated with Diabetic Foot Ulcers

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB, 51PharmGKB
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Compounds related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1dithranol459.8KRT16, KRT10
2ttnpb45 29 1111.8KRT16, GJA1
3calcipotriol45 61 29 1112.8KRT10, KRT16
4isotretinoin45 1110.7KRT16, KRT10
5isoleucine459.6KRT10, GJA1
6polyglycolic acid459.6TGFB3, PDGFB
7bromodeoxyuridine459.4KRT10, GJA1, PDGFB
8tcdd459.4KRT10, TGFB3
91,25 dihydroxy vitamin d3459.3GJA1, KRT10, KRT16
10calcitriol45 61 24 1112.3KRT16, KRT10, GJA1
11retinoid459.3KRT16, KRT10, GJA1
12tgf beta1459.2PDGFB, TGFB3
13proline459.2GJA1, KRT10, KRT16
14progestin459.1TGFB3, GJA1
15ribonucleic acid459.0GJA1, PDGFB, TGFB3
16thymidine45 249.9GJA1, PDGFB, TGFB3
17serine458.7PDGFB, GJA1, KRT10, KRT16
18progesterone45 29 61 24 1112.6TGFB3, PDGFB, GJA1, KRT10
19dexamethasone45 51 29 1111.6TGFB3, PDGFB, GJA1, KRT10
20steroid458.6KRT16, KRT10, TGFB3
21estrogen458.6TGFB3, PDGFB, GJA1, KRT10
22nitric oxide45 24 1110.5TGFB3, PDGFB, GJA1, KRT16
23retinoic acid45 249.4TGFB3, GJA1, KRT10, KRT16
24vegf458.4GJA1, PDGFB, TGFB3
25tyrosine458.3KRT10, GJA1, PDGFB, TGFB3
26paraffin458.1KRT16, KRT10, GJA1, PDGFB, TGFB3

GO Terms for genes affiliated with Diabetic Foot Ulcers

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16Gene Ontology
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Cellular components related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5KRT16, KRT10
2platelet alpha granule lumenGO:0310938.9PDGFB, TGFB3

Biological processes related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glomerular filtrationGO:0031049.7GJA1, PDGFB
2positive regulation of DNA replicationGO:0457409.4PDGFB, TGFB3
3positive regulation of cell divisionGO:0517819.4PDGFB, TGFB3
4cell growthGO:0160499.3PDGFB, TGFB3
5platelet degranulationGO:0025769.2TGFB3, PDGFB
6heart developmentGO:0075079.2GJA1, PDGFB
7response to hypoxiaGO:0016669.2PDGFB, TGFB3
8transforming growth factor beta receptor signaling pathwayGO:0071799.1PDGFB, TGFB3

Products for genes affiliated with Diabetic Foot Ulcers

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  • Antibodies
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Sources for Diabetic Foot Ulcers

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet