Aliases & Classifications for Diabetic Foot Ulcers

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Sources:
30LifeMap Discovery®, 44Novoseek, 61UMLS
See all sources

Aliases & Descriptions for Diabetic Foot Ulcers:

Name: Diabetic Foot Ulcers 30 44
Diabetic Foot Ulcer 61
 
Diabetic Foot 61


Summaries for Diabetic Foot Ulcers

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Wikipedia:64 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

MalaCards based summary: Diabetic Foot Ulcers, also known as diabetic foot ulcer, is related to hypertrophic scars and melanoma. An important gene associated with Diabetic Foot Ulcers is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Renal cell carcinoma. The compounds dithranol and ttnpb have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are limbs/digits/tail and integument.

Related Diseases for Diabetic Foot Ulcers

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Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic scars30.2TGFB3, KRT16
2melanoma29.8GJA1, PDGFB, TGFB3
3blindness10.6
4osteomyelitis10.6
5critical limb ischemia10.5
6ischemia10.5
7endotheliitis10.4
8limb ischemia10.3
9peripheral artery disease10.3
10artery disease10.3
11arthropathy10.3
12neuropathy10.3
13pneumonia10.3
14steatocystoma multiplex10.2KRT16, KRT10
15bowen syndrome10.2KRT16, KRT10
16epidermolytic hyperkeratosis10.2KRT16, KRT10
17epidermolysis bullosa simplex10.2KRT10, KRT16
18palmoplantar keratoderma, nonepidermolytic10.2KRT10, KRT16
19keratosis10.2KRT16, KRT10
20lichen planus10.2KRT16, KRT10
21cholesteatoma10.2KRT16, KRT10
22peripheral vascular disease10.2
23lymphedema10.2
24amelanotic melanoma10.2
25hyperglycemia10.2
26kidney disease10.2
27peripheral neuropathy10.2
28retinitis10.2
29scleritis10.2
30tetanus10.2
31vascular disease10.2
32papilloma10.1GJA1, KRT10
33basal cell carcinoma10.1KRT10, KRT16
34glioblastoma multiforme10.1GJA1, PDGFB
35rhabdomyosarcoma10.1GJA1, PDGFB
36noonan syndrome 110.1GJA1, PDGFB
37pulmonary fibrosis10.0PDGFB, TGFB3
38uterine fibroid10.0GJA1, TGFB3
39leiomyoma10.0GJA1, TGFB3
40systemic scleroderma10.0TGFB3, PDGFB
41palmoplantar keratosis10.0GJA1, KRT10, KRT16
42skin disease10.0GJA1, KRT10, KRT16
43cataract9.9GJA1, TGFB3
44lung benign neoplasm9.9GJA1, PDGFB
45liver cirrhosis9.9TGFB3, PDGFB
46osteosarcoma, somatic9.8TGFB3, PDGFB, GJA1
47adenocarcinoma9.6TGFB3, PDGFB, GJA1, KRT10
48tongue squamous cell carcinoma9.4TGFB3, PDGFB, GJA1, KRT10, KRT16

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to diabetic foot ulcers

Symptoms for Diabetic Foot Ulcers

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Drugs & Therapeutics for Diabetic Foot Ulcers

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Genetic Tests for Diabetic Foot Ulcers

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Anatomical Context for Diabetic Foot Ulcers

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MalaCards organs/tissues related to Diabetic Foot Ulcers:

31
Skin, Bone, Bone marrow, Colon, Testes, Endothelial, Heart, Kidney

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Diabetic Foot Ulcers or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7KRT10, GJA1, TGFB3
2MP:00107718.5PDGFB, GJA1, KRT10, KRT16
3MP:00053828.2KRT16, KRT10, GJA1, TGFB3
4MP:00107687.4TGFB3, PDGFB, GJA1, KRT10, KRT16

Publications for Diabetic Foot Ulcers

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Articles related to Diabetic Foot Ulcers:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Cost-effectiveness of clostridial collagenase ointment on wound closure in patients with diabetic foot ulcers: economic analysis of results from a multicenter, randomized, open-label trial. (25767565)
2015
2
Efficacy of intralesional recombinant human epidermal growth factor in chronic diabetic foot ulcers. (25856197)
2015
3
Elevated costs and high one-year mortality in patients with diabetic foot ulcers after surgery. (25872555)
2015
4
Pathogenesis and management of diabetic foot ulcers. (25853673)
2015
5
High matrix metalloproteinase levels are associated with dermal graft failure in diabetic foot ulcers. (25106443)
2014
6
Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers. (25168880)
2014
7
Efficacy of topical application of beta urogastrone (recombinant human epidermal growth factor) in Wagner's Grade 1 and 2 diabetic foot ulcers: Comparative analysis of 50 patients. (25097397)
2014
8
IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers. (23671876)
2013
9
Diabetic foot ulcer microbiome: one small step for molecular microbiology . . . One giant leap for understanding diabetic foot ulcers? (23431007)
2013
10
Hydrocolloid dressings for healing diabetic foot ulcers. (23922167)
2013
11
Increasing incidence of Gram-negative organisms in bacterial agents isolated from diabetic foot ulcers. (24129622)
2013
12
Understanding diabetic foot ulcers. (24002373)
2013
13
Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. (24391454)
2013
14
The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial. (23566071)
2013
15
Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. (24358275)
2013
16
A pilot study evaluating noncontact low frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers. (23163982)
2012
17
A retrospective study of diabetic foot ulcers treated with hyperbaric oxygen therapy. (22372584)
2012
18
Diffuse near-infrared spectroscopy prediction of healing in diabetic foot ulcers: a human study and cost analysis. (23110417)
2012
19
Role of negative pressure wound therapy in healing of diabetic foot ulcers. (22022646)
2011
20
Prospective randomized controlled study of a Chinese herbal medicine compound Tangzu Yuyang Ointment for chronic diabetic foot ulcers: a preliminary report. (21129474)
2011
21
The impact of creatinine clearance on the outcome of diabetic foot ulcers in north Indian tertiary care hospital. (22813563)
2011
22
Bioengineered skin in diabetic foot ulcers. (20380651)
2010
23
Diabetic foot ulcers treated with becaplermin and TheraGauze, a moisture-controlling smart dressing: a randomized, multicenter, prospective analysis. (20479444)
2010
24
Does cell therapy and tissue engineering represent a promising treatment of diabetic foot ulcers? (20437823)
2010
25
Role of early surgical revascularization in the management of refractory diabetic foot ulcers in patients without overt ischemic limbs. (20152756)
2010
26
Clinical signs of infection in diabetic foot ulcers with high microbial load. (19147524)
2009
27
Clinical effectiveness of an acellular dermal regenerative tissue matrix compared to standard wound management in healing diabetic foot ulcers: a prospective, randomised, multicentre study. (19368581)
2009
28
An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. (19065083)
2008
29
Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers: a 6.5-year follow-up study. (18390801)
2008
30
Wound-related pain is underestimated in patients with diabetic foot ulcers. (18947021)
2008
31
Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing. (18387077)
2008
32
Using honey to heal diabetic foot ulcers. (18600072)
2008
33
Virulence potential of Staphylococcus aureus strains isolated from diabetic foot ulcers: a new paradigm. (18809632)
2008
34
Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. (18400121)
2008
35
A comparison of the health-related quality of life in patients with diabetic foot ulcers, with a diabetes group and a nondiabetes group from the general population. (17091370)
2007
36
A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers. (18044080)
2007
37
A feasibility study of UMTS mobile phones for supporting nurses doing home visits to patients with diabetic foot ulcers. (17059653)
2006
38
Diabetic foot ulcers. (16484268)
2006
39
The efficacy of Apligraf in the treatment of diabetic foot ulcers. (16799383)
2006
40
Tetanus prophylaxis for diabetic foot ulcers. (17067894)
2006
41
Telemedical treatment at home of diabetic foot ulcers. (16375785)
2005
42
Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infections. (15659542)
2005
43
Optimal treatment of infected diabetic foot ulcers. (15493949)
2004
44
The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcers. (15562198)
2004
45
Diabetic foot ulcers. (12737879)
2003
46
Growth factors in the treatment of diabetic foot ulcers. (12555288)
2003
47
A comparison of plantar pressure in patients with diabetic foot ulcers using different hosiery. (15871969)
2002
48
Effects of felted foam on plantar pressures in the treatment of neuropathic diabetic foot ulcers. (11723100)
2001
49
Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers. (10727985)
2000
50
Diabetic foot ulcers. A guide to treatment. (11702311)
2000

Variations for Diabetic Foot Ulcers

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Expression for genes affiliated with Diabetic Foot Ulcers

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Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for genes affiliated with Diabetic Foot Ulcers

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Pathways related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.2PDGFB, TGFB3
29.2PDGFB, TGFB3
3
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.1GJA1, TGFB3
4
Show member pathways
MAPK signaling pathway36
8.6PDGFB, TGFB3, HSPA1L

Compounds for genes affiliated with Diabetic Foot Ulcers

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Compounds related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

(show all 26)
idCompoundScoreTop Affiliating Genes
1dithranol449.8KRT10, KRT16
2ttnpb44 28 1111.8GJA1, KRT16
3calcipotriol44 60 28 1112.8KRT10, KRT16
4isotretinoin44 1110.7KRT16, KRT10
5isoleucine449.6GJA1, KRT10
6polyglycolic acid449.6TGFB3, PDGFB
7bromodeoxyuridine449.4GJA1, PDGFB, KRT10
8tcdd449.4TGFB3, KRT10
91,25 dihydroxy vitamin d3449.3KRT16, KRT10, GJA1
10calcitriol44 60 24 1112.3KRT10, KRT16, GJA1
11retinoid449.3GJA1, KRT10, KRT16
12tgf beta1449.2PDGFB, TGFB3
13proline449.2KRT16, KRT10, GJA1
14progestin449.1GJA1, TGFB3
15ribonucleic acid449.0PDGFB, TGFB3, GJA1
16thymidine44 249.9GJA1, TGFB3, PDGFB
17serine448.7GJA1, KRT10, KRT16, PDGFB
18progesterone44 28 60 24 1112.6KRT10, GJA1, PDGFB, TGFB3
19dexamethasone44 50 28 1111.6PDGFB, GJA1, KRT10, TGFB3
20steroid448.6KRT16, KRT10, TGFB3
21estrogen448.6GJA1, TGFB3, PDGFB, KRT10
22nitric oxide44 24 1110.5KRT16, GJA1, TGFB3, PDGFB
23retinoic acid44 249.4KRT10, TGFB3, KRT16, GJA1
24vegf448.4PDGFB, GJA1, TGFB3
25tyrosine448.3GJA1, PDGFB, TGFB3, KRT10
26paraffin448.1KRT16, TGFB3, PDGFB, GJA1, KRT10

GO Terms for genes affiliated with Diabetic Foot Ulcers

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Cellular components related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5KRT16, KRT10
2platelet alpha granule lumenGO:00310938.9PDGFB, TGFB3

Biological processes related to Diabetic Foot Ulcers according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glomerular filtrationGO:00031049.7GJA1, PDGFB
2positive regulation of DNA replicationGO:00457409.4PDGFB, TGFB3
3positive regulation of cell divisionGO:00517819.4PDGFB, TGFB3
4cell growthGO:00160499.3PDGFB, TGFB3
5platelet degranulationGO:00025769.2TGFB3, PDGFB
6heart developmentGO:00075079.2GJA1, PDGFB
7response to hypoxiaGO:00016669.2PDGFB, TGFB3
8transforming growth factor beta receptor signaling pathwayGO:00071799.1PDGFB, TGFB3

Sources for Diabetic Foot Ulcers

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet