MCID: DBT062
MIFTS: 52

Diabetic Foot Ulcers malady

Summaries for Diabetic Foot Ulcers

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

MalaCards: Diabetic Foot Ulcers is related to hypertrophic scars and vascular disease. An important gene associated with Diabetic Foot Ulcers is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are TOB in T-Cell Signaling and NF-KappaB Family Pathway. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and colon, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Aliases & Classifications for Diabetic Foot Ulcers

Sources:
31LifeMap Discovery™, 45Novoseek
See all sources

Aliases & Descriptions:

diabetic foot ulcers 31 45


Related Diseases for Diabetic Foot Ulcers

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic scars30.2FGF2, KRT16, TGFBR2, TGFB3
2vascular disease30.2PDGFB, CRP, FGF2, MMP9, NOS3, TGFBR1
3critical limb ischemia10.4
4arthropathy10.3
5peripheral vascular disease10.1
6amelanotic melanoma10.1
7tetanus10.1
8klebsiella10.1
9type 1 diabetes10.1
10split foot10.1
11sarcoma10.0PDGFB
12nephritis10.0PDGFB
13dilated cardiomyopathy10.0GJA1
14infertility10.0TGFB2
15thyroiditis10.0CALCA
16hereditary hemorrhagic telangiectasia10.0TGFBR1
17dermatitis10.0KRT16
18medulloblastoma10.0PDGFB
19endometriosis10.0IL15
20gallbladder cancer10.0TGFBR2
21pancreatitis10.0CRP
22hypercalcemia10.0CALCA
23celiac disease10.0IL15
24myeloid leukemia10.0CSF3
25giant cell tumor10.0CALCA
26anorexia nervosa10.0TTR
27hyperparathyroidism10.0CALCA
28migraine10.0CALCA
29essential hypertension10.0NOS3
30laryngeal squamous cell carcinoma10.0TGFBR2
31multiple myeloma10.0CSF3
32ulcerative colitis10.0CRP
33acute leukemia10.0CSF3
34crohn's disease10.0CRP
35polycystic ovary syndrome10.0CRP
36psoriatic arthritis10.0CRP
37pyelonephritis10.0CRP
38bullous keratopathy10.0TGFB2
39lupus erythematosus10.0F2
40myelodysplastic syndromes10.0CSF3
41hepatitis b10.0F2
42periodontal disease10.0CRP
43abdominal aortic aneurysm10.0MMP9
44intracranial aneurysm10.0NOS3
45ependymoma10.0TTR
46oligodendroglioma10.0GJA1
47goiter10.0CALCA
48skin disease10.0MMP9
49graves' disease10.0NOS3
50polyneuropathy10.0TTR

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to diabetic foot ulcers

Clinical Features for Diabetic Foot Ulcers

Drugs & Therapeutics for Diabetic Foot Ulcers

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Foot Ulcers

Drug clinical trials:

Search ClinicalTrials for Diabetic Foot Ulcers

Search NIH Clinical Center for Diabetic Foot Ulcers

Search CenterWatch for Diabetic Foot Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Foot Ulcers cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Foot Ulcers

Anatomical Context for Diabetic Foot Ulcers

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Diabetic Foot Ulcers:

33
Bone marrow, Heart, Colon, Kidney, Skin, T cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Diabetic Foot Ulcers or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2PDGFB, TGFB2
2MP:00053779.8KRT10, GJA1
3MP:00036319.8F2, GJA1, PDGFB, HSPA1B
4MP:00053899.7EGF, IL15, MMP9, TGFB2
5MP:00053809.6PDGFB, GJA1, F2, TGFBR2, TGFB3, TGFB2
6MP:00053909.5FGF2, GJA1, NOS3, TGFB3, TGFBR1, TGFB2
7MP:00053829.4KRT16, KRT10, TGFBR2, TGFB3, TGFB2, GJA1
8MP:00053919.4PDGFB, EGF, FGF2, GJA1, TTR, TGFB3
9MP:00053889.4MMP9, GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
10MP:00020069.4CALCA, MMP9, KRT10, TGFBR2, TGFBR1
11MP:00107719.4CALCA, PDGFB, MMP9, GJA1, F2, KRT16
12MP:00053699.1PDGFB, FGF2, MMP9, GJA1, NOS3, TGFBR2
13MP:00053819.0EGF, MMP9, F2, KRT16, NOS3, TGFBR2
14MP:00053768.8CALCA, PDGFB, CRP, GJA1, F2, TTR
15MP:00028738.8CALCA, EGF, GJA1, F2, NOS3, TGFBR2
16MP:00053858.4TGFB2, HSPA1B, CALCA, PDGFB, CRP, IL15
17MP:00053978.2PDGFB, CSF3, FGF2, IL15, MMP9, GJA1
18MP:00053788.0HSPA1B, PDGFB, EGF, IL15, MMP9, GJA1
19MP:00053847.9HSPA1B, FGF2, IL15, MMP9, GJA1, F2
20MP:00053877.6IL15, EGF, CRP, CSF3, PDGFB, HSPA1B
21MP:00107687.6MMP9, IL15, FGF2, PDGFB, CALCA, HSPA1B

Publications for Diabetic Foot Ulcers

Sources:
51PubMed
See all sources

Articles related to Diabetic Foot Ulcers:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Diabetic foot ulcers treated with hyperbaric oxygen therapy: a review of the literature. (22747586)
2014
2
Does the location of the ulcer affect the interpretation of the probe-to-bone test in the diagnosis of osteomyelitis in diabetic foot ulcers? (23865848)
2014
3
Increasing incidence of Gram-negative organisms in bacterial agents isolated from diabetic foot ulcers. (24129622)
2013
4
The bacteriology of diabetic foot ulcers, with a special reference to multidrug resistant strains. (23634392)
2013
5
Molecular epidemiology of Staphylococcus aureus strains isolated from inpatients with infected diabetic foot ulcers in an Algerian University Hospital. (23521557)
2013
6
Angiosome-targeted revascularisation in diabetic foot ulcers. (24118695)
2013
7
Maggot debridement therapy for the treatment of diabetic foot ulcers: a meta-analysis. (24005780)
2013
8
Risk factors for recurrence of diabetic foot ulcers: prospective follow-up analysis in the Eurodiale subgroup. (22712631)
2013
9
A retrospective study of diabetic foot ulcers treated with hyperbaric oxygen therapy. (22372584)
2012
10
Systematic review and mixed treatment comparison: dressings to heal diabetic foot ulcers. (22544222)
2012
11
Associated risk factors and management of chronic diabetic foot ulcers exceeding 6 months' duration. (23119125)
2012
12
The role of hyperbaric oxygen in the treatment of diabetic foot ulcers. (21873346)
2012
13
Factor XIII Val34Leu polymorphism is associated with increased factor XIII activation and decreased transcutaneous oxygen readings in patients with diabetic foot ulcers. (22578139)
2012
14
Alcohol consumption and other psycho-social conditions as important factors in the development of diabetic foot ulcers. (21219424)
2011
15
Flexible and rigid casting tape as a novel approach to offloading diabetic foot ulcers. (21841722)
2011
16
A pilot study on the effects of a polyherbal formulation cream on diabetic foot ulcers. (21911968)
2011
17
Extended leg infection of diabetic foot ulcers: risk factors and outcome. (22068143)
2011
18
The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series. (22279458)
2011
19
Wound fluid lactate concentration: a helpful marker for diagnosing soft-tissue infection in diabetic foot ulcers? Preliminary findings. (21219425)
2011
20
Enhanced healing of diabetic foot ulcers using local heat and electrical stimulation for 30 min three times per week. (20923474)
2010
21
Beneficial effects of implementing guidelines on microbiology and costs of infected diabetic foot ulcers. (20571753)
2010
22
Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence. (20411235)
2010
23
Is oral administration of Chinese herbal medicine effective and safe as an adjunctive therapy for managing diabetic foot ulcers? A systematic review and meta-analysis. (20673140)
2010
24
Diabetic foot ulcers and ethnicity in Tanzania: a contrast between African and Asian populations. (19368580)
2009
25
Limitations of magnetic resonance imaging in the diagnosis of osteomyelitis underlying diabetic foot ulcers. (19067621)
2009
26
An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. (19065083)
2008
27
Using honey to heal diabetic foot ulcers. (18600072)
2008
28
Risk factors and healing impact of multidrug-resistant bacteria in diabetic foot ulcers. (18632297)
2008
29
Comparison of four systems of classification of diabetic foot ulcers in Tanzania. (18215177)
2008
30
An economic evaluation of VAC therapy compared with wound dressings in the treatment of diabetic foot ulcers. (18389832)
2008
31
Treatment of chronic diabetic foot ulcers with bemiparin: a randomized, triple-blind, placebo-controlled, clinical trial. (19183313)
2008
32
A comparison of the health-related quality of life in patients with diabetic foot ulcers, with a diabetes group and a nondiabetes group from the general population. (17091370)
2007
33
In vitro activity of tigecycline against strains isolated from diabetic foot ulcers. (17905534)
2007
34
Treatment of long-standing, poor-healing diabetic foot ulcers with topical negative pressure in the Torres Strait. (17617094)
2007
35
Peripheral neuropathy in patients with diabetic foot ulcers: clinical and nerve conduction study. (17399742)
2007
36
Dermal regeneration template in the surgical management of diabetic foot ulcers: a series of five cases. (16399556)
2006
37
Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. (17014667)
2006
38
Does close glycaemic control promote healing in diabetic foot ulcers? Report of a feasibility study. (16026373)
2005
39
Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases. (15505764)
2004
40
Effect of initial weight-bearing in a total contact cast on healing of diabetic foot ulcers. (15590858)
2004
41
An economic evaluation of the cost of diabetic foot ulcers: results of a retrospective study on 239 patients. (12909815)
2003
42
The efficacy and safety of Dermagraft in improving the healing of chronic diabetic foot ulcers: results of a prospective randomized trial. (12766097)
2003
43
Applied felted foam for plantar pressure relief is an efficient therapy in neuropathic diabetic foot ulcers. (12397530)
2002
44
Cost-effectiveness of treating deep diabetic foot ulcers with Promogran in four European countries. (11901743)
2002
45
Microbiological profile of infected diabetic foot ulcers. (12647846)
2002
46
Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. (11213881)
2001
47
Diabetic foot ulcers. A guide to treatment. (11702311)
2000
48
Assessment of infection in diabetic foot ulcers. (11933415)
2000
49
Treatment of diabetic foot ulcers with hyperbaric oxygen. (11933305)
2000
50
Cost-effectiveness modeling of Dermagraft for the treatment of diabetic foot ulcers in the french context. (10804327)
2000

Genetic Variations for Diabetic Foot Ulcers

Expression for genes affiliated with Diabetic Foot Ulcers

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Foot Ulcers

Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for genes affiliated with Diabetic Foot Ulcers

Sources:
52QIAGEN, 30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 56SinoBiological, 4Cell Signaling Technology
See all sources

Pathways related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TGFB3
2
Hide members
10.2PDGFB, TGFB3
3
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10.1TGFB3, TGFBR1
4
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10.1TGFB3, TGFBR1
510.1TGFB3, TGFBR1
6
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10.1TGFBR1, TGFBR2
7
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10.1TGFBR2, TGFBR1
810.1TGFBR2, TGFBR1
9
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10.1TGFBR2, TGFBR1
10
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10.1TGFBR1, TGFBR2
11
Hide members
10.1PDGFB, F2
12
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10.0PDGFB, TGFB3, TGFBR1
13
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10.0NOS3, F2
149.9TGFBR2, TGFB3, TGFBR1
159.9TGFBR2, TGFB3, TGFBR1
169.9TGFBR1, TGFB3, TGFBR2
179.9TGFBR1, TGFB3, TGFBR2
189.9TGFBR1, TGFB3, TGFBR2
199.9TGFBR1, TGFB3, TGFBR2
209.9TGFBR1, TGFB3, TGFBR2
219.9MMP9, FGF2
229.9EGF, TGFBR2, TGFBR1
23
Hide members
9.9F2, EGF, PDGFB
249.8HSPA1L, HSPA1B, TGFBR1
259.8MMP9, GJA1, NOS3
26
CFTR folding and maturation (norm and CF)
9.8NOS3, HSPA1B, HSPA1L
27
Hide members
9.8TGFB2, TGFB3, EGF, PDGFB
289.7TGFBR2, TGFB3, TGFBR1, TGFB2
29
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9.7TGFBR2, TGFB3, TGFBR1, TGFB2
30
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9.7TGFBR2, TGFB3, TGFBR1, TGFB2
31
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9.7EGF, TGFBR2, TGFB3, TGFBR1
32
Hide members
9.7TGFB3, TTR, FGF2, PDGFB
339.6TGFBR1, TGFBR2, IL15, PDGFB
34
Development PDGF signaling via STATs and NF-kB
Hide members
9.6PDGFB, FGF2, F2, NOS3
359.5NOS3, MMP9, FGF2, PDGFB
36
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9.5TGFBR1, TGFB3, FGF2, EGF, PDGFB
37
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9.3TGFBR1, TGFB3, TGFBR2, PDGFB, HSPA1B, HSPA1L
38
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9.3PDGFB, FGF2, MMP9, F2, TTR
39
Hide members
9.3PDGFB, FGF2, NOS3, TGFBR2, TGFB3, TGFBR1
409.2PDGFB, CSF3, EGF, FGF2, NOS3
41
Hide members
9.2PDGFB, EGF, FGF2, NOS3, TGFB3, TGFB2
429.2PDGFB, EGF, FGF2, MMP9, TGFBR2, TGFBR1
439.2FGF2, MMP9, NOS3, TGFB3, TGFBR1, TGFB2
44
Hide members
9.1PDGFB, CSF3, IL15, TGFBR2, TGFB3, TGFBR1
459.1HSPA1L, HSPA1B, EGF, TGFBR2, TGFB3, TGFBR1
46
Hide members
9.0PDGFB, EGF, FGF2, MMP9, TGFB3, TGFBR1
47
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9.0PDGFB, CRP, EGF, FGF2, NOS3, TGFBR2
48
Hide members
9.0PDGFB, EGF, FGF2, IL15, TGFBR2, TGFB3
49
Hide members
8.9HSPA1B, PDGFB, CSF3, EGF, IL15, TGFBR2
50
Hide members
8.6NOS3, IL15, FGF2, EGF, CSF3, PDGFB

Compounds for genes affiliated with Diabetic Foot Ulcers

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7TTR
2pge24510.6MMP9
3cycloheximide4510.6PDGFB, GJA1
4tamoxifen45 50 29 1113.4TGFBR2, GJA1
5hydrocortisone45 2 60 1113.3FGF2, CALCA
6dithranol4510.1KRT16, KRT10, EGF
7p0054510.1TGFB2, IL15, TGFBR2
8trapidil4510.0FGF2, EGF, MMP9
9polyglycolic acid4510.0PDGFB, FGF2, TGFB3
10vitamin a45 11 2412.0TGFB2, KRT16, MMP9, FGF2
111,25 dihydroxy vitamin d3459.9KRT16, GJA1, CALCA, TGFB2, KRT10
12rantes459.8IL15, CSF3
13fluvastatin45 50 29 1112.7GJA1, CRP, NOS3, MMP9
14homocysteine45 2410.7TTR, F2, GJA1, CRP, NOS3
15serine459.7MMP9, PDGFB, GJA1, KRT16, TGFBR1, FGF2
16dihydrotestosterone45 29 11 2412.7TGFBR1, FGF2, TGFBR2, TGFB2, EGF
17creatinine459.7TGFB2, MMP9, F2, TTR, CRP
18bleomycin45 1110.7PDGFB, CSF3, FGF2, MMP9, TGFBR2
19agar459.6FGF2, GJA1, PDGFB, TGFB2, EGF, TTR
20matrigel459.6TGFBR1, EGF, IL15, GJA1, NOS3, TGFB2
21vitamin d459.6TGFBR2, TGFB2, TTR, KRT10, NOS3, CALCA
22methylcellulose459.5IL15, KRT10, EGF, FGF2, CSF3
23hyaluronic acid45 2410.5FGF2, MMP9, TTR, TGFB2, F2
24bromodeoxyuridine459.4FGF2, EGF, PDGFB, GJA1, KRT10, IL15
25sb 20358045 6010.4GJA1, NOS3, CRP, FGF2, EGF, MMP9
26pd 98,059459.4NOS3, GJA1, EGF, PDGFB, FGF2, MMP9
27ascorbic acid45 2410.3FGF2, TGFB2, CRP, NOS3, TTR
28cyclophosphamide45 50 1111.3CRP, IL15, MMP9, NOS3, CSF3
295fluorouracil459.3CSF3, EGF, TGFB3, TGFB2, IL15
30nitric oxide45 11 2411.3NOS3, TGFB3, KRT16, GJA1, IL15, CALCA
31ribonucleic acid459.3TGFB3, TGFBR2, MMP9, TGFBR1, TGFB2, IL15
32calcitriol45 60 11 2412.3TGFB2, KRT10, KRT16, F2, GJA1, FGF2
33steroid459.2IL15, EGF, KRT16, KRT10, TGFB3, TGFB2
34testosterone45 60 11 2412.2TGFB2, CALCA, CRP, EGF, MMP9, GJA1
35methotrexate45 50 1111.2IL15, CSF3, MMP9, F2, CRP, NOS3
36adenylate459.2CALCA, GJA1, EGF, IL15, TTR, TGFBR2
37epinephrine45 11 2411.2CALCA, F2, CSF3, TTR
38progesterone45 60 29 11 2413.1TGFBR2, TGFB3, EGF, IL15, TGFBR1, TGFB2
39genistein45 29 60 2 11 2414.1NOS3, TGFB2, TTR, MMP9, GJA1, TGFBR1
40ly294002459.1CRP, EGF, FGF2, MMP9, GJA1, NOS3
41thymidine45 2410.0FGF2, IL15, TGFB2, TGFB3, PDGFB, CSF3
42dexamethasone45 50 29 1112.0IL15, TGFB2, TGFBR1, TGFB3, TGFBR2, GJA1
43paraffin459.0KRT10, TGFB3, TGFB2, TGFBR1, KRT16, TTR
44tgf beta1459.0PDGFB, EGF, TGFB2, TGFBR1, TGFB3, TGFBR2
45tyrosine458.8GJA1, PDGFB, CSF3, EGF, IL15, TGFB2
46cyclosporin a45 29 6010.8F2, IL15, FGF2, CALCA, CSF3, PDGFB
47alanine458.8TGFBR1, TTR, F2, GJA1, IL15, FGF2
48phosphatidylinositol458.7MMP9, TGFB2, NOS3, GJA1, IL15, FGF2
49retinoic acid45 248.8FGF2, EGF, CSF3, IL15, MMP9, TGFB2
50vegf457.8CALCA, PDGFB, CSF3, CRP, FGF2, IL15

GO Terms for genes affiliated with Diabetic Foot Ulcers

Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:07002210.1TGFBR1, TGFBR2
2platelet alpha granule lumenGO:0310939.5PDGFB, EGF, TGFB3, TGFB2
3extracellular regionGO:0055767.9EGF, CRP, PDGFB, CALCA, FGF2, IL15
4extracellular spaceGO:0056157.6TGFB2, CALCA, PDGFB, CSF3, CRP, EGF

Biological processes related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:00018610.5FGF2
2positive regulation of hyaluronan biosynthetic processGO:190012710.5PDGFB, EGF
3menstrual cycle phaseGO:02260110.4TGFB3, TGFB2
4negative regulation of macrophage cytokine productionGO:01093610.4TGFB3, TGFB2
5salivary gland morphogenesisGO:00743510.3TGFB2, TGFB3
6positive regulation of cerebellar granule cell precursor proliferationGO:02194010.3EGF, FGF2
7pathway-restricted SMAD protein phosphorylationGO:06038910.3TGFB2, TGFBR1, TGFBR2
8lens development in camera-type eyeGO:00208810.3GJA1, TGFBR2, TGFBR1
9response to cholesterolGO:07072310.3TGFBR1, TGFBR2
10cell growthGO:01604910.3PDGFB, TGFB3, TGFB2
11positive regulation of reactive oxygen species metabolic processGO:200037910.2TGFBR2, F2, PDGFB
12negative regulation of platelet activationGO:01054410.2NOS3, F2, PDGFB
13endothelial cell migrationGO:04354210.2TGFBR1, NOS3, CALCA
14peptidyl-serine phosphorylationGO:01810510.2TGFBR1, TGFBR2, PDGFB
15palate developmentGO:06002110.2TGFBR2, TGFB3, TGFBR1
16response to woundingGO:00961110.2PDGFB, F2, TGFB2
17positive regulation of immune responseGO:05077810.2TGFB2, IL15
18activation of protein kinase activityGO:03214710.2TGFB2, TGFBR2, PDGFB, CALCA
19embryo implantationGO:00756610.2TGFBR2, MMP9, CALCA
20platelet degranulationGO:00257610.1TGFB2, TGFB3, EGF, PDGFB
21SMAD protein import into nucleusGO:00718410.1TGFB3, TGFB2
22positive regulation of cell divisionGO:05178110.1PDGFB, FGF2, TGFB3, TGFB2
23negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.1TGFBR2, TGFB3, TGFBR1
24positive regulation of ossificationGO:04577810.1TGFB2, CALCA
25response to hypoxiaGO:00166610.1PDGFB, CRP, TGFB3, TGFB2
26transforming growth factor beta receptor signaling pathwayGO:00717910.0PDGFB, TGFBR2, TGFB3, TGFBR1, TGFB2
27heart developmentGO:00750710.0PDGFB, GJA1, TGFBR2, TGFBR1, TGFB2
28positive regulation of cell growthGO:03030710.0TGFB2, TGFBR1, F2
29positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.0TGFB2, F2, CSF3, PDGFB
30angiogenesisGO:0015259.9EGF, NOS3, TGFBR1, TGFB2
31in utero embryonic developmentGO:0017019.9GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
32protein phosphorylationGO:0064689.9TGFB2, TGFBR1, TGFBR2, PDGFB, CALCA
33platelet activationGO:0301689.9PDGFB, EGF, F2, TGFB3, TGFB2
34wound healingGO:0420609.8CRP, FGF2, TGFBR2, TGFBR1, TGFB2
35positive regulation of SMAD protein import into nucleusGO:0603919.8TGFBR1, TGFB3
36agingGO:0075689.8CALCA, CRP, IL15, TGFBR2, TGFB3
37extracellular matrix organizationGO:0301989.6PDGFB, FGF2, MMP9, TTR, TGFB3, TGFB2
38blood coagulationGO:0075969.6PDGFB, EGF, F2, NOS3, TGFB3, TGFB2
39positive regulation of transcription, DNA-dependentGO:0458939.5PDGFB, EGF, FGF2, TGFB3, TGFBR1
40negative regulation of cell proliferationGO:0082859.5HSPA1B, FGF2, GJA1, NOS3, TGFB3, TGFB2
41cell-cell signalingGO:0072679.5TGFB2, GJA1, IL15, CALCA
42positive regulation of cell proliferationGO:0082848.8TGFB2, PDGFB, CSF3, EGF, FGF2, IL15

Molecular functions related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:03471310.1TGFB3, TGFBR2
2type II transforming growth factor beta receptor bindingGO:00511410.1TGFB3, TGFBR1, TGFB2
3transforming growth factor beta bindingGO:05043110.0TGFBR1, TGFB3, TGFBR2
4transmembrane receptor protein serine/threonine kinase activityGO:00467510.0TGFBR1, TGFBR2
5receptor signaling protein serine/threonine kinase activityGO:0047029.8TGFBR2, TGFB2
6receptor bindingGO:0051029.7TGFB2, F2, GJA1, CALCA
7cytokine activityGO:0051259.4CSF3, FGF2, IL15, TGFB2
8growth factor activityGO:0080839.1TGFB2, PDGFB, CSF3, EGF, FGF2, F2
9protein bindingGO:0055156.9IL15, FGF2, EGF, CRP, PDGFB, CALCA

Products for genes affiliated with Diabetic Foot Ulcers

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Sources for Diabetic Foot Ulcers

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet