MCID: DBT062
MIFTS: 56

Diabetic Foot Ulcers malady

Summaries for Diabetic Foot Ulcers

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of... more...

MalaCards: Diabetic Foot Ulcers is related to osteomyelitis and ischemia. An important gene associated with Diabetic Foot Ulcers is PDGFB (platelet-derived growth factor beta polypeptide), and among its related pathways are TOB in T-Cell Signaling and NF-KappaB Family Pathway. The compounds estrogen and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are renal/urinary system and hearing/vestibular/ear.

Aliases & Classifications for Diabetic Foot Ulcers

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30LifeMap Discovery™, 44Novoseek
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Aliases & Descriptions:

diabetic foot ulcers 30 44


Related Diseases for Diabetic Foot Ulcers

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Foot Ulcers via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1osteomyelitis30.7CRP
2ischemia30.5PDGFB, FGF2, GJA1, NOS3, TGFBR1, TGFB2
3neuropathy30.4CALCA, TTR
4pneumonia30.4CSF3, CRP, TGFB2
5hypertrophic scars30.1FGF2, KRT16, TGFBR2, TGFB3
6diabetes mellitus30.1CALCA, CRP, MMP9, NOS3
7vascular disease30.1PDGFB, CRP, FGF2, MMP9, NOS3, TGFBR1
8melanoma30.1HSPA1B, PDGFB, FGF2, IL15, MMP9, GJA1
9critical limb ischemia10.4
10arthropathy10.3
11diabetic neuropathy10.3
12peripheral vascular disease10.1
13amelanotic melanoma10.1
14hyperglycemia10.1
15kidney disease10.1
16lymphedema10.1
17peripheral neuropathy10.1
18retinitis10.1
19scleritis10.1
20tetanus10.1
21sarcoma10.0PDGFB
22nephritis10.0PDGFB
23dilated cardiomyopathy10.0GJA1
24infertility10.0TGFB2
25thyroiditis10.0CALCA
26hereditary hemorrhagic telangiectasia10.0TGFBR1
27dermatitis10.0KRT16
28medulloblastoma10.0PDGFB
29endometriosis10.0IL15
30gallbladder cancer10.0TGFBR2
31pancreatitis10.0CRP
32hypercalcemia10.0CALCA
33celiac disease10.0IL15
34myeloid leukemia10.0CSF3
35giant cell tumor10.0CALCA
36anorexia nervosa10.0TTR
37hyperparathyroidism10.0CALCA
38migraine10.0CALCA
39essential hypertension10.0NOS3
40laryngeal squamous cell carcinoma10.0TGFBR2
41multiple myeloma10.0CSF3
42ulcerative colitis10.0CRP
43acute leukemia10.0CSF3
44crohn's disease10.0CRP
45polycystic ovary syndrome10.0CRP
46psoriatic arthritis10.0CRP
47pyelonephritis10.0CRP
48bullous keratopathy10.0TGFB2
49lupus erythematosus10.0F2
50myelodysplastic syndromes10.0CSF3

Graphical network of the top 20 diseases related to Diabetic Foot Ulcers:



Diseases related to diabetic foot ulcers

Clinical Features for Diabetic Foot Ulcers

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Drugs & Therapeutics for Diabetic Foot Ulcers

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Foot Ulcers

Drug clinical trials:

Search ClinicalTrials for Diabetic Foot Ulcers

Search NIH Clinical Center for Diabetic Foot Ulcers

Search CenterWatch for Diabetic Foot Ulcers

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Foot Ulcers cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Foot Ulcers

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Anatomical Context for Diabetic Foot Ulcers

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Diabetic Foot Ulcers:

32
Skin, Bone, Bone marrow, Colon, Endothelial, Testes, Heart, Kidney

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Foot Ulcers:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Diabetic Foot Ulcers or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Foot Ulcers:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2PDGFB, TGFB2
2MP:00053779.8KRT10, GJA1
3MP:00036319.8F2, GJA1, PDGFB, HSPA1B
4MP:00053899.7EGF, IL15, MMP9, TGFB2
5MP:00053809.6PDGFB, GJA1, F2, TGFBR2, TGFB3, TGFB2
6MP:00053909.5FGF2, GJA1, NOS3, TGFB3, TGFBR1, TGFB2
7MP:00053829.4KRT16, KRT10, TGFBR2, TGFB3, TGFB2, GJA1
8MP:00053919.4PDGFB, EGF, FGF2, GJA1, TTR, TGFB3
9MP:00053889.4MMP9, GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
10MP:00020069.4CALCA, MMP9, KRT10, TGFBR2, TGFBR1
11MP:00107719.4CALCA, PDGFB, MMP9, GJA1, F2, KRT16
12MP:00053699.1PDGFB, FGF2, MMP9, GJA1, NOS3, TGFBR2
13MP:00053819.0EGF, MMP9, F2, KRT16, NOS3, TGFBR2
14MP:00053768.8CALCA, PDGFB, CRP, GJA1, F2, TTR
15MP:00028738.8CALCA, EGF, GJA1, F2, NOS3, TGFBR2
16MP:00053858.4TGFB2, HSPA1B, CALCA, PDGFB, CRP, IL15
17MP:00053978.2PDGFB, CSF3, FGF2, IL15, MMP9, GJA1
18MP:00053788.0HSPA1B, PDGFB, EGF, IL15, MMP9, GJA1
19MP:00053847.9HSPA1B, FGF2, IL15, MMP9, GJA1, F2
20MP:00053877.6IL15, EGF, CRP, CSF3, PDGFB, HSPA1B
21MP:00107687.6MMP9, IL15, FGF2, PDGFB, CALCA, HSPA1B

Publications for Diabetic Foot Ulcers

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50PubMed
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Articles related to Diabetic Foot Ulcers:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
Localization of human mesenchymal stem cells from umbilical cord blood and their role in repair of diabetic foot ulcers in rats. (24391454)
2013
2
Serum prolidase activity in diabetic foot ulcers. (23242638)
2013
3
Vascular surgery, microsurgery and supramicrosurgery for treatment of chronic diabetic foot ulcers to prevent amputations. (24058622)
2013
4
Hydrogel dressings for healing diabetic foot ulcers. (23846869)
2013
5
The effect of flexor tenotomy on healing and prevention of neuropathic diabetic foot ulcers on the distal end of the toe. (23347589)
2013
6
Topical Phenytoin Application in Grade I and II Diabetic Foot Ulcers: A Prospective Study. (24298485)
2013
7
ACP Journal Club. Review: in patients with chronic diabetic foot ulcers, hyperbaric oxygen reduces major amputations. (24026285)
2013
8
Risk factors, ulcer grade and management outcome of diabetic foot ulcers in a Tropical Tertiary Care Hospital. (23661901)
2013
9
The investigation of demographic characteristics and the health-related quality of life in patients with diabetic foot ulcers at first presentation. (23008342)
2012
10
Prevalence of diabetic foot ulcers in newly diagnosed diabetes mellitus patients. (23741832)
2012
11
Diabetic foot ulcers: evaluation and management. (23086099)
2012
12
Efficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers. (21751891)
2011
13
Comparison of demographic and clinical characteristics influencing health-related quality of life in patients with diabetic foot ulcers and those without foot ulcers. (22253537)
2011
14
A retrospective clinical study of 188 consecutive patients to examine the effectiveness of a biologically active cryopreserved human skin allograft (TheraSkinAr) on the treatment of diabetic foot ulcers and venous leg ulcers. (21135263)
2011
15
A multidisciplinary diabetic foot ulcer treatment programme significantly improved the outcome in patients with infected diabetic foot ulcers. (21216682)
2011
16
Two-step autologous grafting using HYAFF scaffolds in treating difficult diabetic foot ulcers: results of a multicenter, randomized controlled clinical trial with long-term follow-up. (21693443)
2011
17
Effectiveness of bridge V.A.C. dressings in the treatment of diabetic foot ulcers. (22396825)
2011
18
Bioengineered skin in diabetic foot ulcers. (20380651)
2010
19
Depression predicts first but not recurrent diabetic foot ulcers. (20556354)
2010
20
Efficacy by ulcer type and safety of lipo-PGE1 for Japanese patients with diabetic foot ulcers. (20484863)
2010
21
A systematic review of scoring systems for diabetic foot ulcers. (20536950)
2010
22
Hyperbaric oxygen therapy in the treatment of diabetic foot ulcers--prudent or problematic: a case report. (20567052)
2010
23
Plasma homocysteine levels are associated with ulceration of the foot in patients with type 2 diabetes mellitus. (20135633)
2010
24
Clinical effectiveness of an acellular dermal regenerative tissue matrix compared to standard wound management in healing diabetic foot ulcers: a prospective, randomised, multicentre study. (19368581)
2009
25
Wound chronicity, inpatient care, and chronic kidney disease predispose to MRSA infection in diabetic foot ulcers. (19587371)
2009
26
Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study. (20051095)
2009
27
Treatment of diabetic foot ulcers with tendon lengthening. (20000296)
2009
28
Wound bioburden and infection-related complications in diabetic foot ulcers. (18647759)
2008
29
Common clinical features of diabetic foot ulcers: perspectives from a developing nation. (18492676)
2008
30
Spectrum of microbial flora in diabetic foot ulcers. (18603682)
2008
31
Screening to identify individuals at high risk of developing diabetic foot ulcers. (18317477)
2008
32
Operative debridement of diabetic foot ulcers. (19183519)
2008
33
Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study. (17558098)
2007
34
Statins may be useful in diabetic foot ulceration treatment and prevention. (17499447)
2007
35
The efficacy of Apligraf in the treatment of diabetic foot ulcers. (16799383)
2006
36
Full nursing assessment of patients at risk of diabetic foot ulcers. (16936596)
2006
37
Limb salvage of infected diabetic foot ulcers with free deep inferior epigastric perforator flaps. (16331655)
2006
38
Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. (17014667)
2006
39
Reliability of free-flap coverage in diabetic foot ulcers. (15633172)
2005
40
Low recruitment of immune cells with increased expression of endothelial adhesion molecules in margins of the chronic diabetic foot ulcers. (15953043)
2005
41
An open-label, randomized study comparing efficacy and safety of intravenous piperacillin/tazobactam and ampicillin/sulbactam for infected diabetic foot ulcers. (15865549)
2005
42
Optimal treatment of infected diabetic foot ulcers. (15493949)
2004
43
Wound healing and treatments for people with diabetic foot ulcers. (15150819)
2004
44
Growth factors in the treatment of diabetic foot ulcers. (12555288)
2003
45
Cost-effectiveness of becaplermin for nonhealing neuropathic diabetic foot ulcers. (14652415)
2003
46
Lower extremity bypass in patients with diabetic foot ulcers. (12822731)
2003
47
Putting our best foot forward: the pharmacist's role in preventing diabetic foot ulcers. (11297340)
2001
48
The effects of ulcer size and site, patient's age, sex and type and duration of diabetes on the outcome of diabetic foot ulcers. (11251677)
2001
49
Risk factors for delayed healing of neuropathic diabetic foot ulcers: a pooled analysis. (11115166)
2000
50
The MABAL shoe, an alternative method in contact casting for the treatment of neuropathic diabetic foot ulcers. (10808972)
2000

Genetic Variations for Diabetic Foot Ulcers

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Expression for genes affiliated with Diabetic Foot Ulcers

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Foot Ulcers

Search GEO for disease gene expression data for Diabetic Foot Ulcers.

Pathways for genes affiliated with Diabetic Foot Ulcers

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 55SinoBiological, 4Cell Signaling Technology
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Pathways related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TGFB3
2
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10.2PDGFB, TGFB3
3
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10.1TGFBR1, TGFB3
4
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10.1TGFB3, TGFBR1
510.1TGFBR1, TGFB3
6
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10.1TGFBR1, TGFBR2
7
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10.1TGFBR1, TGFBR2
810.1TGFBR2, TGFBR1
9
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10.1TGFBR1, TGFBR2
10
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10.1TGFBR1, TGFBR2
11
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10.1PDGFB, F2
12
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10.0TGFBR1, TGFB3, PDGFB
13
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10.0NOS3, F2
149.9TGFBR2, TGFBR1, TGFB3
159.9TGFBR1, TGFBR2, TGFB3
169.9TGFBR2, TGFB3, TGFBR1
179.9TGFB3, TGFBR2, TGFBR1
189.9TGFB3, TGFBR2, TGFBR1
199.9TGFB3, TGFBR1, TGFBR2
209.9TGFBR1, TGFB3, TGFBR2
219.9MMP9, FGF2
229.9EGF, TGFBR2, TGFBR1
23
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9.9F2, EGF, PDGFB
249.8TGFBR1, HSPA1L, HSPA1B
259.8NOS3, GJA1, MMP9
26
CFTR folding and maturation (norm and CF)
9.8HSPA1L, HSPA1B, NOS3
27
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9.8PDGFB, EGF, TGFB2, TGFB3
289.7TGFB2, TGFBR1, TGFBR2, TGFB3
29
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9.7TGFB2, TGFBR2, TGFB3, TGFBR1
30
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9.7TGFBR1, TGFB2, TGFB3, TGFBR2
31
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9.7TGFB3, TGFBR1, TGFBR2, EGF
32
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9.7TTR, PDGFB, TGFB3, FGF2
339.6PDGFB, IL15, TGFBR2, TGFBR1
34
Development PDGF signaling via STATs and NF-kB
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9.6PDGFB, NOS3, F2, FGF2
359.5MMP9, PDGFB, FGF2, NOS3
36
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9.5TGFBR1, PDGFB, FGF2, TGFB3, EGF
37
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9.3TGFBR1, HSPA1L, PDGFB, TGFBR2, TGFB3, HSPA1B
38
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9.3F2, PDGFB, MMP9, TTR, FGF2
39
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9.3TGFBR2, NOS3, TGFBR1, PDGFB, TGFB3, FGF2
409.2PDGFB, CSF3, EGF, FGF2, NOS3
41
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9.2FGF2, PDGFB, EGF, NOS3, TGFB3, TGFB2
429.2MMP9, FGF2, PDGFB, TGFBR1, EGF, TGFBR2
439.2NOS3, FGF2, MMP9, TGFB3, TGFBR1, TGFB2
44
Hide members
9.1PDGFB, CSF3, IL15, TGFBR2, TGFBR1, TGFB3
459.1HSPA1L, EGF, TGFBR2, TGFB3, TGFBR1, HSPA1B
46
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9.0PDGFB, FGF2, MMP9, TGFB3, TGFBR1, TGFB2
47
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9.0FGF2, TGFBR1, TGFBR2, NOS3, PDGFB, CRP
48
Hide members
9.0PDGFB, TGFBR2, EGF, FGF2, IL15, TGFBR1
49
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8.9EGF, PDGFB, HSPA1B, IL15, CSF3, TGFBR2
50
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8.6NOS3, FGF2, PDGFB, IL15, TGFB3, CSF3

Compounds for genes affiliated with Diabetic Foot Ulcers

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 24HMDB
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Compounds related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7TTR
2pge24410.6MMP9
3cycloheximide4410.6PDGFB, GJA1
4tamoxifen44 49 28 1113.4TGFBR2, GJA1
5hydrocortisone44 2 59 1113.3FGF2, CALCA
6dithranol4410.1KRT16, KRT10, EGF
7p0054410.1TGFB2, IL15, TGFBR2
8trapidil4410.0FGF2, EGF, MMP9
9polyglycolic acid4410.0PDGFB, FGF2, TGFB3
10vitamin a44 11 2412.0TGFB2, KRT16, MMP9, FGF2
111,25 dihydroxy vitamin d3449.9KRT16, GJA1, CALCA, TGFB2, KRT10
12rantes449.8IL15, CSF3
13fluvastatin44 49 28 1112.7GJA1, CRP, NOS3, MMP9
14homocysteine44 2410.7TTR, F2, GJA1, CRP, NOS3
15serine449.7MMP9, PDGFB, GJA1, KRT16, TGFBR1, FGF2
16dihydrotestosterone44 28 11 2412.7TGFBR1, FGF2, TGFBR2, TGFB2, EGF
17creatinine449.7TGFB2, MMP9, F2, TTR, CRP
18bleomycin44 1110.7PDGFB, CSF3, FGF2, MMP9, TGFBR2
19agar449.6FGF2, GJA1, PDGFB, TGFB2, EGF, TTR
20matrigel449.6TGFBR1, EGF, IL15, GJA1, NOS3, TGFB2
21vitamin d449.6TGFBR2, TGFB2, TTR, KRT10, NOS3, CALCA
22methylcellulose449.5IL15, KRT10, EGF, FGF2, CSF3
23hyaluronic acid44 2410.5FGF2, MMP9, TTR, TGFB2, F2
24bromodeoxyuridine449.4FGF2, EGF, PDGFB, GJA1, KRT10, IL15
25sb 20358044 5910.4GJA1, NOS3, CRP, FGF2, EGF, MMP9
26pd 98,059449.4NOS3, GJA1, EGF, PDGFB, FGF2, MMP9
27ascorbic acid44 2410.3FGF2, TGFB2, CRP, NOS3, TTR
28cyclophosphamide44 49 1111.3CRP, IL15, MMP9, NOS3, CSF3
295fluorouracil449.3CSF3, EGF, TGFB3, TGFB2, IL15
30nitric oxide44 11 2411.3NOS3, TGFB3, KRT16, GJA1, IL15, CALCA
31ribonucleic acid449.3TGFB3, TGFBR2, MMP9, TGFBR1, TGFB2, IL15
32calcitriol44 59 11 2412.3TGFB2, KRT10, KRT16, F2, GJA1, FGF2
33steroid449.2IL15, EGF, KRT16, KRT10, TGFB3, TGFB2
34testosterone44 59 11 2412.2TGFB2, CALCA, CRP, EGF, MMP9, GJA1
35methotrexate44 49 1111.2IL15, CSF3, MMP9, F2, CRP, NOS3
36adenylate449.2CALCA, GJA1, EGF, IL15, TTR, TGFBR2
37epinephrine44 11 2411.2CALCA, F2, CSF3, TTR
38progesterone44 59 28 11 2413.1TGFBR2, TGFB3, EGF, IL15, TGFBR1, TGFB2
39genistein44 28 59 2 11 2414.1NOS3, TGFB2, TTR, MMP9, GJA1, TGFBR1
40ly294002449.1CRP, EGF, FGF2, MMP9, GJA1, NOS3
41thymidine44 2410.0FGF2, IL15, TGFB2, TGFB3, PDGFB, CSF3
42dexamethasone44 49 28 1112.0IL15, TGFB2, TGFBR1, TGFB3, TGFBR2, GJA1
43paraffin449.0KRT10, TGFB3, TGFB2, TGFBR1, KRT16, TTR
44tgf beta1449.0PDGFB, EGF, TGFB2, TGFBR1, TGFB3, TGFBR2
45tyrosine448.8GJA1, PDGFB, CSF3, EGF, IL15, TGFB2
46cyclosporin a44 28 5910.8F2, IL15, FGF2, CALCA, CSF3, PDGFB
47alanine448.8TGFBR1, TTR, F2, GJA1, IL15, FGF2
48phosphatidylinositol448.7MMP9, TGFB2, NOS3, GJA1, IL15, FGF2
49retinoic acid44 248.8FGF2, EGF, CSF3, IL15, MMP9, TGFB2
50vegf447.8CALCA, PDGFB, CSF3, CRP, FGF2, IL15

GO Terms for genes affiliated with Diabetic Foot Ulcers

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16Gene Ontology
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Cellular components related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor homodimeric complexGO:07002210.1TGFBR1, TGFBR2
2platelet alpha granule lumenGO:0310939.5PDGFB, EGF, TGFB3, TGFB2
3extracellular regionGO:0055767.9EGF, CRP, PDGFB, CALCA, FGF2, IL15
4extracellular spaceGO:0056157.6TGFB2, CALCA, PDGFB, CSF3, CRP, EGF

Biological processes related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPKK activityGO:00018610.5FGF2
2positive regulation of hyaluronan biosynthetic processGO:190012710.5PDGFB, EGF
3menstrual cycle phaseGO:02260110.4TGFB3, TGFB2
4negative regulation of macrophage cytokine productionGO:01093610.4TGFB3, TGFB2
5salivary gland morphogenesisGO:00743510.3TGFB2, TGFB3
6positive regulation of cerebellar granule cell precursor proliferationGO:02194010.3EGF, FGF2
7pathway-restricted SMAD protein phosphorylationGO:06038910.3TGFB2, TGFBR1, TGFBR2
8lens development in camera-type eyeGO:00208810.3GJA1, TGFBR2, TGFBR1
9response to cholesterolGO:07072310.3TGFBR1, TGFBR2
10cell growthGO:01604910.3PDGFB, TGFB3, TGFB2
11positive regulation of reactive oxygen species metabolic processGO:200037910.2TGFBR2, F2, PDGFB
12negative regulation of platelet activationGO:01054410.2NOS3, F2, PDGFB
13endothelial cell migrationGO:04354210.2TGFBR1, NOS3, CALCA
14peptidyl-serine phosphorylationGO:01810510.2TGFBR1, TGFBR2, PDGFB
15palate developmentGO:06002110.2TGFBR2, TGFB3, TGFBR1
16response to woundingGO:00961110.2PDGFB, F2, TGFB2
17positive regulation of immune responseGO:05077810.2TGFB2, IL15
18activation of protein kinase activityGO:03214710.2TGFB2, TGFBR2, PDGFB, CALCA
19embryo implantationGO:00756610.2TGFBR2, MMP9, CALCA
20platelet degranulationGO:00257610.1TGFB2, TGFB3, EGF, PDGFB
21SMAD protein import into nucleusGO:00718410.1TGFB3, TGFB2
22positive regulation of cell divisionGO:05178110.1PDGFB, FGF2, TGFB3, TGFB2
23negative regulation of transforming growth factor beta receptor signaling pathwayGO:03051210.1TGFBR2, TGFB3, TGFBR1
24positive regulation of ossificationGO:04577810.1TGFB2, CALCA
25response to hypoxiaGO:00166610.1PDGFB, CRP, TGFB3, TGFB2
26transforming growth factor beta receptor signaling pathwayGO:00717910.0PDGFB, TGFBR2, TGFB3, TGFBR1, TGFB2
27heart developmentGO:00750710.0PDGFB, GJA1, TGFBR2, TGFBR1, TGFB2
28positive regulation of cell growthGO:03030710.0TGFB2, TGFBR1, F2
29positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.0TGFB2, F2, CSF3, PDGFB
30angiogenesisGO:0015259.9EGF, NOS3, TGFBR1, TGFB2
31in utero embryonic developmentGO:0017019.9GJA1, NOS3, TGFBR2, TGFB3, TGFBR1
32protein phosphorylationGO:0064689.9TGFB2, TGFBR1, TGFBR2, PDGFB, CALCA
33platelet activationGO:0301689.9PDGFB, EGF, F2, TGFB3, TGFB2
34wound healingGO:0420609.8CRP, FGF2, TGFBR2, TGFBR1, TGFB2
35positive regulation of SMAD protein import into nucleusGO:0603919.8TGFBR1, TGFB3
36agingGO:0075689.8CALCA, CRP, IL15, TGFBR2, TGFB3
37extracellular matrix organizationGO:0301989.6PDGFB, FGF2, MMP9, TTR, TGFB3, TGFB2
38blood coagulationGO:0075969.6PDGFB, EGF, F2, NOS3, TGFB3, TGFB2
39positive regulation of transcription, DNA-dependentGO:0458939.5PDGFB, EGF, FGF2, TGFB3, TGFBR1
40negative regulation of cell proliferationGO:0082859.5HSPA1B, FGF2, GJA1, NOS3, TGFB3, TGFB2
41cell-cell signalingGO:0072679.5TGFB2, GJA1, IL15, CALCA
42positive regulation of cell proliferationGO:0082848.8TGFB2, PDGFB, CSF3, EGF, FGF2, IL15

Molecular functions related to Diabetic Foot Ulcers according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:03471310.1TGFB3, TGFBR2
2type II transforming growth factor beta receptor bindingGO:00511410.1TGFB3, TGFBR1, TGFB2
3transforming growth factor beta bindingGO:05043110.0TGFBR1, TGFB3, TGFBR2
4transmembrane receptor protein serine/threonine kinase activityGO:00467510.0TGFBR1, TGFBR2
5receptor signaling protein serine/threonine kinase activityGO:0047029.8TGFBR2, TGFB2
6receptor bindingGO:0051029.7TGFB2, F2, GJA1, CALCA
7cytokine activityGO:0051259.4CSF3, FGF2, IL15, TGFB2
8growth factor activityGO:0080839.1TGFB2, PDGFB, CSF3, EGF, FGF2, F2
9protein bindingGO:0055156.9IL15, FGF2, EGF, CRP, PDGFB, CALCA

Products for genes affiliated with Diabetic Foot Ulcers

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  • Antibodies
  • Proteins
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Sources for Diabetic Foot Ulcers

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet