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Diabetic Ketoacidosis malady

Summaries for Diabetic Ketoacidosis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes... more...

MalaCards: Diabetic Ketoacidosis, also known as diabetes mellitus, ketosis-prone, is related to type 1 diabetes and diabetes mellitus. An important gene associated with Diabetic Ketoacidosis is PAX4 (paired box 4), and among its related pathways are GABA synthesis and Beta-alanine metabolism. The drugs insulin and insulin, aspart, human and the compounds norepinephrine and oxygen have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Description from OMIM:46 612227

Aliases & Classifications for Diabetic Ketoacidosis

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8Disease Ontology, 44Novoseek, 60UMLS, 9diseasecard, 46OMIM, 22GTR, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Aliases & Descriptions:

diabetic ketoacidosis 8 44 60
diabetes mellitus, ketosis-prone 8 9 46
ketosis-prone diabetes mellitus 8 22
diabetes mellitus, insulin-dependent 60


External Ids:

Disease Ontology8 DOID:1837
OMIM46 612227
ICD9CM27 250.1
MeSH34 D016883
NCIt39 C50530

Related Diseases for Diabetic Ketoacidosis

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Ketoacidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1type 1 diabetes31.4HNF4A, CTLA4, GAD2, GAD1, INS, TPO
2diabetes mellitus31.1AGER, SST, INS, PAX4, ADRB3, PIK3C2A
3pancreatitis30.8INS, SST
4metabolic acidosis30.7PIK3C2A, CHKB, BTD, AQP2
5acute pancreatitis30.6IL18, SST
6hyperglycemia30.6HNF4A, LSL, GAD2, GAD1, AGER, SST
7brain edema30.6CLDN5
8hypokalemia30.4PIK3C2A, INS, AQP2
9hypoglycemia30.4HNF4A, LSL, GAD1, SST, BTD, INS
10obesity30.4HNF4A, LSL, GAD2, AGER, INS, IL18
11hypertension30.4INS, ADRB3
12hepatitis30.4HNF4A, CTLA4, IL18
13type 2 diabetes mellitus30.3HNF4A, LSL, GAD2, GAD1, AGER, INS
14candidiasis30.2BTD
15neuropathy30.2INS, PIK3C2A
16thyroiditis30.2TPO, GAD2, CTLA4
17eating disorder30.2INS
18diabetic neuropathy30.2GAD2, GAD1, AGER, INS
19gestational diabetes30.2HNF4A, LSL, GAD1, INS, ADRB3
20myocardial infarction30.2LSL, TNNI3, PIK3C2A, AGER, CHKB, TPO
21hepatitis c30.2LSL, CTLA4, IL18
22anorexia nervosa30.0LSL
23pneumonia30.0PIK3C2A
24alopecia30.0BTD
25connective tissue disease30.0CTLA4
26down syndrome30.0TPO
27viral hepatitis30.0G6PD
28addison's disease30.0TPO, CTLA4
29cushing's syndrome30.0INS, SST
30cystic fibrosis30.0BTD, INS, AQP2
31ischemia30.0GAD2, GAD1, PIK3C2A, CHKB
32adenocarcinoma30.0HNF4A, SST, CLDN5
33arthritis30.0IL18, AGER, CTLA4
34duchenne muscular dystrophy30.0TNNI3, PIK3C2A, CHKB
35hypopituitarism30.0AQP2, INS, SST
36graves' disease30.0CTLA4, GAD2, GAD1, HLA-DQB1, TPO
37maturity-onset diabetes of the young30.0PAX4, INS, HNF4A
38adenoma30.0HNF4A, CTLA4, SST, INS, TPO
39rheumatoid arthritis30.0CTLA4, HLA-DQB1, AGER, CHKB, IL18
40cerebritis10.8
41type 1 diabetes mellitus10.5
42acromegaly10.5
43wolfram syndrome10.4
44epiphyseal dysplasia multiple with early-onset diabetes mellitus10.4
45diabetes mellitus, insulin-dependent, 1910.4
46diabetes mellitus, insulin-dependent, 710.4
47diabetes mellitus, insulin-dependent, 1310.4
48diabetes mellitus, insulin-dependent, 2210.4
49diabetes mellitus, insulin-dependent, 2310.4
50diabetes mellitus, insulin-dependent, 1810.4

Graphical network of the top 20 diseases related to Diabetic Ketoacidosis:



Diseases related to diabetic ketoacidosis

Clinical Features for Diabetic Ketoacidosis

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46OMIM
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Clinical features from OMIM:

612227

Clinical synopsis from OMIM:

612227

Genetic Tests for Diabetic Ketoacidosis

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22GTR
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Genetic tests related to Diabetic Ketoacidosis:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Ketosis-Prone22

Anatomical Context for Diabetic Ketoacidosis

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32MalaCards
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MalaCards organs/tissues related to Diabetic Ketoacidosis:

32
Brain, Testes, Pituitary, Heart, Thyroid, Liver, Small intestine, Spinal cord, Monocytes, Endothelial, Pancreatic islet, Bone

Animal Models for Diabetic Ketoacidosis or affiliated genes

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36MGI
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Publications for Diabetic Ketoacidosis

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50PubMed
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Articles related to Diabetic Ketoacidosis:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Treatment of diabetic ketoacidosis with subcutaneous insulin lispro: a review of the current evidence from clinical studies. (23642642)
2013
2
Clinical and socio-demographic factors associated with diabetic ketoacidosis hospitalization in adults with Type 1 diabetes. (23323955)
2013
3
Severe hypercalcemia in diabetic ketoacidosis: a case report. (23520372)
2013
4
Response to letter: use of bicarbonate in the management of diabetic ketoacidosis. (24084620)
2013
5
Diabetic ketoacidosis at diagnosis in Austrian children: a population-based analysis, 1989-2011. (23953724)
2013
6
T-wave inversion in diabetic ketoacidosis with normokalemia in an adolescent. (22806711)
2013
7
Acid-base disorder analysis during diabetic ketoacidosis using the Stewart approach - a case report. (24407901)
2013
8
Alcohol induced diabetic ketoacidosis exacerbated by an acute respiratory infection with Klebsiella pneumoniae. (23772471)
2013
9
Diabetic ketoacidosis; could we do better? (23586807)
2013
10
Severe diabetic ketoacidosis in combination with starvation and anorexia nervosa at onset of type 1 diabetes: a case report. (23544963)
2013
11
The role of point-of-care I^-hydroxybutyrate testing in the diagnosis of diabetic ketoacidosis: a review. (22615081)
2012
12
A warning from India: hypovolemia may be as dangerous as excessive fluid infusion for cerebral edema in diabetic ketoacidosis. (22391841)
2012
13
Brain tissue oxygenation-guided management of diabetic ketoacidosis induced cerebral edema*. (22895005)
2012
14
Risk factors for cerebral edema in diabetic ketoacidosis in a developing country: role of fluid refractory shock. (22391852)
2012
15
Plasmapheresis to treat hypertriglyceridemia in a child with diabetic ketoacidosis and pancreatitis. (22201145)
2012
16
Too much of a good thing: management of diabetic ketoacidosis in adults. (22267622)
2012
17
Diabetic ketoacidosis: a silent death. (22835961)
2012
18
Management of diabetic ketoacidosis. (21526698)
2011
19
Diabetic ketoacidosis preceding thrombocytopenia associated multiple organ failure in a child. (21206100)
2011
20
A rare case: Shwachman-Diamond syndrome presenting with diabetic ketoacidosis. (21448781)
2011
21
Comprehensive case study--diabetic ketoacidosis. (22409121)
2011
22
Cannabis masks diabetic ketoacidosis. (22679145)
2011
23
Tuberculous meningitis associated with diabetic ketoacidosis. (22155468)
2011
24
Utility of initial bolus insulin in the treatment of diabetic ketoacidosis. (18514472)
2010
25
Adherance to protocol during the acute management of diabetic ketoacidosis: would specialist involvement lead to better outcomes? (20846206)
2010
26
Diabetic ketoacidosis associated with severe hypoglycemia. (20386088)
2010
27
Profile of diabetic ketoacidosis at a teaching hospital in Benghazi, Libyan Arab Jamahiriya. (20795443)
2010
28
Erosive gastritis, Armanni-Ebstein phenomenon and diabetic ketoacidosis. (20632132)
2010
29
Malignant somatostatinoma presenting with diabetic ketoacidosis and inhibitory syndrome: pathophysiologic considerations. (20497932)
2010
30
Insulin and IGF-1 receptors, nitrotyrosin and cerebral neuronal deficits in two young patients with diabetic ketoacidosis and fatal brain edema. (20420811)
2010
31
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
32
Diabetic ketoacidosis with cytomegalovirus-associated colitis. (19252359)
2009
33
Diabetic ketoacidosis caused by exposure of insulin pump to heat and sunlight. (19124546)
2009
34
Diabetic ketoacidosis: the usual villain or a scapegoat? A novel cause of severe metabolic acidosis in type 1 diabetes. (18308676)
2008
35
A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. (18651203)
2008
36
Cerebral blood flow and cerebral edema in rats with diabetic ketoacidosis. (18633109)
2008
37
Prolonged QT interval corrected for heart rate during diabetic ketoacidosis in children. (18524745)
2008
38
Can we prevent diabetic ketoacidosis in children? (17727382)
2007
39
Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein. (16009359)
2005
40
Subcutaneous use of a fast-acting insulin analog: an alternative treatment for pediatric patients with diabetic ketoacidosis. (16043723)
2005
41
Fatal cerebral infarctions in diabetic ketoacidosis in a child with previously unknown heterozygosity for factor V Leiden deficiency. (15480386)
2004
42
Rhabdomyolysis in diabetic ketoacidosis. (14655521)
2003
43
Diabetic ketoacidosis in children: review of pathophysiology and treatment with the use of the "two bags system" (14647613)
2001
44
Diabetic ketoacidosis. (10195849)
1999
45
Pituitary gigantism causing diabetic ketoacidosis. (10614552)
1999
46
Effects of long-acting somatostatin analogue (Sandostatin) on manifest diabetic ketoacidosis. (10765004)
1999
47
Leukemoid reaction associated with diabetic ketoacidosis--with measurement of plasma levels of granulocyte colony-stimulating factor. (7516746)
1993
48
The clinical and hormonal (C-peptide and glucagon) profile and liability to ketoacidosis during nutritional rehabilitation in Ethiopian patients with malnutrition-related diabetes mellitus. (2112100)
1990
49
Practical management of diabetic ketoacidosis and hyperosmolar coma. (2127177)
1990
50
Recurrent ketoacidosis in acquired, total lipodystrophy (lipoatrophic diabetes). (6432502)
1984

Genetic Variations for Diabetic Ketoacidosis

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Expression for genes affiliated with Diabetic Ketoacidosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Ketoacidosis

Search GEO for disease gene expression data for Diabetic Ketoacidosis.

Pathways for genes affiliated with Diabetic Ketoacidosis

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53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 51QIAGEN
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Compounds for genes affiliated with Diabetic Ketoacidosis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.6ADRB3, CHKB
2oxygen44 2411.2ADRB3, TPO, GAD1, PIK3C2A
3gemfibrozil44 28 1112.2G6PD, PIK3C2A, INS, CHKB
4hydrocortisone44 2 59 1113.2LSL, INS, AQP2, TPO
5dexamethasone44 49 28 1113.2CTLA4, INS, ADRB3, AQP2, HNF4A
6streptozotocin4410.2INS, SST, AGER, GAD1
7beta-hydroxybutyrate4410.1CHKB, INS, LSL
8bezafibrate44 28 1112.1HNF4A, PIK3C2A, CHKB, INS
9uric acid44 2411.1TPO, ADRB3, PIK3C2A, G6PD, CHKB
10olanzapine49 44 28 11 2414.1ADRB3, INS, CHKB, LSL
11methimazole44 2 1112.1IL18, LSL, TPO, G6PD
12malondialdehyde4410.0LSL, G6PD, CHKB, PIK3C2A, AGER
13acipimox44 2811.0LSL, INS, SST
14choline44 11 2412.0PIK3C2A, SST, CHKB, GAD1, GAD2
15acetylcholine44 49 28 11 2414.0CTLA4, IL18, TPO, SST, GAD1, GAD2
16prednisolone44 28 1112.0LSL, IL18, CHKB, PIK3C2A, GAD1
17potassium44 11 2412.0GAD1, ADRB3, TPO, AQP2, PIK3C2A, TNNI3
18hydrogen44 2411.0HNF4A, GAD1, CHKB, LSL, TPO, AQP2
19fatty acid449.9CHKB, LSL, BTD, HNF4A, PIK3C2A
20urea44 11 2411.9PIK3C2A, HNF4A, LSL, CHKB, ADRB3, AQP2
21cyclosporin a44 28 5911.8GAD1, PIK3C2A, CTLA4, AQP2, IL18, GAD2
22lithium44 49 11 2412.8TPO, AQP2, LSL, HNF4A
23acth449.8TPO, SST, INS, PIK3C2A, LSL
24glycerol44 11 2411.8LSL, AQP2, CHKB, INS, PIK3C2A, G6PD
25glycogen44 2410.8HNF4A, PIK3C2A, CHKB, BTD, INS, ADRB3
26thyroxine44 2410.8SST, TPO, INS, CHKB, LSL, G6PD
27fibrinogen449.8CHKB, TPO, IL18, INS, LSL, PIK3C2A
28c-peptide449.7GAD2, SST, GAD1, HNF4A, ADRB3, INS
29adenylate449.7G6PD, ADRB3, CHKB, TPO, AQP2, IL18
30glucose449.6AQP2, GAD1, GAD2, HNF4A, PAX4, PIK3C2A
31aspartate449.5G6PD, PIK3C2A, GAD1, HLA-DQB1, CHKB, LSL
32cysteine449.5AQP2, CHKB, BTD, GAD1, TPO, IL18
33epinephrine44 11 2411.5CHKB, G6PD, LSL, SST, PIK3C2A, ADRB3
34lactate449.5INS, LSL, IL18, G6PD, PIK3C2A, TNNI3
35atp44 2810.5GAD2, CHKB, G6PD, HNF4A, ADRB3, AQP2
36steroid449.4GAD1, TPO, HNF4A, IL18, CHKB, LSL
37glutamine449.4G6PD, IL18, CHKB, HNF4A, GAD1, HLA-DQB1
38estrogen449.4CHKB, G6PD, CTLA4, HNF4A, LSL, IL18
39oligonucleotide449.4GAD1, HLA-DQB1, GAD2, HNF4A, CLDN5, TPO
40testosterone44 59 11 2412.4PIK3C2A, SST, INS, IL18, TPO, HNF4A
41nitric oxide44 11 2411.4AGER, GAD2, LSL, GAD1, IL18, TPO
42methotrexate44 49 1111.3CHKB, IL18, LSL, CTLA4, PIK3C2A
43alanine449.3HNF4A, AQP2, CTLA4, INS, ADRB3, CHKB
44creatinine449.2IL18, INS, CHKB, AGER, TPO, GAD1
45glutamate449.2TPO, IL18, INS, SST, PIK3C2A, HLA-DQB1
46tyrosine449.2PIK3C2A, HLA-DQB1, GAD1, GAD2, CTLA4, AGER
47lipid449.2ADRB3, G6PD, IL18, HNF4A, PIK3C2A, CTLA4
48cholesterol44 28 11 2412.1HNF4A, LSL, CTLA4, GAD2, AGER, CHKB
49arginine449.0CHKB, INS, IL18, AQP2, TPO, BTD
50calcium44 49 11 2411.8HNF4A, IL18, TPO, AQP2, CLDN5, CHKB

GO Terms for genes affiliated with Diabetic Ketoacidosis

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16Gene Ontology
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Cellular components related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.9GAD1, GAD2
2plasma membraneGO:0058868.9GAD2, GAD1, HLA-DQB1, PIK3C2A, AGER, CLDN5

Biological processes related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.2GAD1, GAD2
2response to drugGO:04249310.0PAX4, SST, GAD1, GAD2
3endocrine pancreas developmentGO:03101810.0PAX4, INS, HNF4A
4hyperosmotic responseGO:0069729.9SST, AQP2

Molecular functions related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate bindingGO:01659510.2GAD1, GAD2
2glutamate decarboxylase activityGO:0043519.9GAD1, GAD2

Products for genes affiliated with Diabetic Ketoacidosis

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Sources for Diabetic Ketoacidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet