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Diabetic Ketoacidosis malady

Summaries for Diabetic Ketoacidosis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes... more...

MalaCards: Diabetic Ketoacidosis, also known as diabetes mellitus, ketosis-prone, is related to metabolic acidosis and acute pancreatitis. An important gene associated with Diabetic Ketoacidosis is PAX4 (paired box 4), and among its related pathways are GABA synthesis and Beta-alanine metabolism. The drugs insulin and insulin, aspart, human and the compounds norepinephrine and oxygen have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Description from OMIM:47 612227

Aliases & Classifications for Diabetic Ketoacidosis

Sources:
8Disease Ontology, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

diabetic ketoacidosis 8 45 61
diabetes mellitus, ketosis-prone 8 9 47
ketosis-prone diabetes mellitus 8 22
diabetes mellitus, insulin-dependent 61


External Ids:

Disease Ontology8 DOID:1837
OMIM47 612227
ICD9CM27 250.1
MeSH35 D016883
NCIt40 C50530

Related Diseases for Diabetic Ketoacidosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Diabetic Ketoacidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 279)
idRelated DiseaseScoreTop Affiliating Genes
1metabolic acidosis30.7PIK3C2A, CHKB, BTD, AQP2
2acute pancreatitis30.7IL18, SST
3brain edema30.6CLDN5
4hypokalemia30.5PIK3C2A, INS, AQP2
5hypertriglyceridemia30.5ADRB3, INS, LSL
6hypoglycemia30.5HNF4A, LSL, GAD1, SST, BTD, INS
7insulin resistance30.5HNF4A, LSL, GAD2, AGER, SST, INS
8gestational diabetes30.3HNF4A, LSL, GAD1, INS, ADRB3
9hepatitis c30.2LSL, CTLA4, IL18
10anorexia nervosa30.0LSL
11alopecia30.0BTD
12viral hepatitis30.0G6PD
13cushing's syndrome30.0INS, SST
14thyroiditis30.0TPO, GAD2, CTLA4
15cystic fibrosis30.0BTD, INS, AQP2
16adenocarcinoma30.0HNF4A, SST, CLDN5
17arthritis30.0IL18, AGER, CTLA4
18duchenne muscular dystrophy30.0TNNI3, PIK3C2A, CHKB
19graves' disease30.0CTLA4, GAD2, GAD1, HLA-DQB1, TPO
20type 1 diabetes30.0HNF4A, CTLA4, GAD2, GAD1, INS, TPO
21adenoma30.0HNF4A, CTLA4, SST, INS, TPO
22acromegaly10.5
23diabetes mellitus, insulin-dependent, 1910.4
24diabetes mellitus, insulin-dependent, 710.4
25diabetes mellitus, insulin-dependent, 1310.4
26diabetes mellitus, insulin-dependent, 2210.4
27diabetes mellitus, insulin-dependent, 2310.4
28diabetes mellitus, insulin-dependent, 1810.4
29diabetes mellitus, insulin-dependent, neonatal10.4
30diabetes mellitus, insulin-dependent, 1510.4
31diabetes mellitus, insulin-dependent, 2110.4
32diabetes mellitus, insulin-dependent, 510.4
33diabetes mellitus, insulin-dependent, 810.4
34diabetes, mellitus, insulin-dependent 1010.4
35diabetes mellitus, insulin-dependent, 2410.4
36diabetes mellitus, insulin-dependent, 1710.4
37diabetes mellitus, insulin-dependent, 210.4
38diabetes mellitus, insulin-dependent, 410.4
39diabetes mellitus, insulin-dependent, 2010.4
40diabetes mellitus, insulin-dependent, 1110.4
41diabetes mellitus, insulin-dependent, 310.4
42diabetes mellitus, insulin-dependent, 610.4
43diabetes mellitus, insulin-dependent, x-linked10.4
44hypophosphatemia10.4
45n syndrome10.3
46chorea10.3
47somatostatinoma10.3
48gigantism10.3
49zygomycosis10.3
50immunodysregulation, polyendocrinopathy and enteropathy x-linked10.2

Graphical network of the top 20 diseases related to Diabetic Ketoacidosis:



Diseases related to diabetic ketoacidosis

Clinical Features for Diabetic Ketoacidosis

Sources:
47OMIM
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Clinical features from OMIM:

612227

Clinical synopsis from OMIM:

612227

Genetic Tests for Diabetic Ketoacidosis

Sources:
22GTR
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Genetic tests related to Diabetic Ketoacidosis:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Ketosis-prone22

Anatomical Context for Diabetic Ketoacidosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Diabetic Ketoacidosis:

33
Liver, Spinal cord, Brain, Heart, Small intestine, Thyroid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Pancreatic islet, Pituitary

Animal Models for Diabetic Ketoacidosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Diabetic Ketoacidosis

Sources:
51PubMed
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Articles related to Diabetic Ketoacidosis:

(show top 50)    (show all 604)
idTitleAuthorsYear
1
Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. (24362895)
2013
2
Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. (23075084)
2013
3
Comparison of diabetic ketoacidosis in patients with type-1 and type-2 diabetes mellitus. (23377164)
2013
4
Treatment of diabetic ketoacidosis with subcutaneous insulin lispro: a review of the current evidence from clinical studies. (23642642)
2013
5
Factors associated with diabetic ketoacidosis at onset of TypeA 1 diabetes in children and adolescents. (23758313)
2013
6
Olanzapine-induced diabetic ketoacidosis and neuroleptic malignant syndrome with rhabdomyolysis: a case report. (24396655)
2013
7
Do obese children with diabetic ketoacidosis have type 1 or type 2 diabetes? (22230097)
2012
8
Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water. (22457081)
2012
9
A warning from India: hypovolemia may be as dangerous as excessive fluid infusion for cerebral edema in diabetic ketoacidosis. (22391841)
2012
10
Severe hyperlipidaemia complicating diabetic ketoacidosis. (22447995)
2012
11
Diabetic ketoacidosis complicated by generalized venous thrombosis: a case report and review. (22356837)
2012
12
Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up. (21972409)
2011
13
Gestational diabetes mellitus with diabetic ketoacidosis in a Yorkshire terrier bitch. (21673334)
2011
14
Predictors of diabetic ketoacidosis in children and adolescents with type 1 diabetes. Experience from a large multicentre database. (21466644)
2011
15
Closing the anion gap: contribution of D-lactate to diabetic ketoacidosis. (21036159)
2011
16
Managing diabetic ketoacidosis in non-intensive care unit setting: Role of insulin analogs. (21844993)
2011
17
Bicarbonate in diabetic ketoacidosis - a systematic review. (21906367)
2011
18
Cerebral infarction associated with transient visual loss in child with diabetic ketoacidosis. (21244475)
2011
19
Gluconeogenesis defect presenting with resistant hyperglycemia and acidosis mimicking diabetic ketoacidosis. (22158280)
2011
20
Current controversies in treatment and prevention of diabetic ketoacidosis. (21056741)
2010
21
Management of diabetic ketoacidosis in children and adolescents in sub-Saharan Africa: a review. (23057293)
2010
22
Diabetic ketoacidosis and memory dysfunction in children with type 1 diabetes. (19833353)
2010
23
Symptomatic cerebral oedema during treatment of diabetic ketoacidosis: effect of adjuvant octreotide infusion. (20723227)
2010
24
Diabetic ketoacidosis in children and adolescents with diabetes. (19754623)
2009
25
Spontaneous pneumomediastinum: rare complication of diabetic ketoacidosis. (21686462)
2009
26
Diabetic ketoacidosis with cytomegalovirus-associated colitis. (19252359)
2009
27
Sodium bicarbonate is beneficial in patients with diabetic ketoacidosis. (19265372)
2009
28
Second-generation antipsychotic-associated diabetes mellitus and diabetic ketoacidosis: mechanisms, predictors, and screening need. (19552870)
2009
29
Cerebral injury and cerebral edema in children with diabetic ketoacidosis: could cerebral ischemia and reperfusion injury be involved? (19821944)
2009
30
Type 1 (distal) renal tubular acidosis in a patient with Type 1 diabetes mellitus--not all cases of metabolic acidosis in Type 1 diabetes mellitus are due to diabetic ketoacidosis. (18199141)
2008
31
Management of diabetic ketoacidosis in children and adolescents. (22975521)
2008
32
Glucocorticoid-induced diabetic ketoacidosis in acute rheumatic fever. (19087951)
2008
33
Multisystemic therapy for adolescents with poorly controlled type 1 diabetes: reduced diabetic ketoacidosis admissions and related costs over 24 months. (18566340)
2008
34
Pheochromocytoma presenting as diabetic ketoacidosis. (18413169)
2008
35
Diabetic ketoacidosis: principles of management. (17953311)
2007
36
Predicting diabetic ketoacidosis in children by measuring end-tidal CO2 via non-invasive nasal capnography. (17854452)
2007
37
A case of pegylated interferon alpha-related diabetic ketoacidosis: can this complication be avoided? (17721757)
2007
38
Femoral venous thrombosis in a 5-week old with diabetic ketoacidosis and a femoral venous catheter. (17998579)
2007
39
Diabetic ketoacidosis in a patient with acromegaly. (17908670)
2007
40
Profound hypokalemia in diabetic ketoacidosis: a therapeutic challenge. (16191494)
2005
41
Diabetic ketoacidosis presenting in a patient with Addison's disease. (15384967)
2004
42
Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis. (14976569)
2003
43
Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis. (12021537)
2002
44
Genital herpes and diabetic ketoacidosis: a patient report. (10587785)
1999
45
Practical management of diabetic ketoacidosis in childhood and adolescence. (9822196)
1998
46
Diabetic ketoacidosis among obese African-American adolescents with NIDDM. (9096965)
1997
47
Locally invasive oral candidiasis mimicking zygomycosis in a patient with diabetic ketoacidosis. (8850487)
1996
48
Hypokalemia-induced respiratory failure complicating treatment of diabetic ketoacidosis. (7661895)
1994
49
Alterations in monocyte receptor function in type 1 diabetic patients with ketoacidosis. (1828734)
1991
50
Diabetic ketoacidosis and pregnancy. (2165729)
1990

Genetic Variations for Diabetic Ketoacidosis

Expression for genes affiliated with Diabetic Ketoacidosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Ketoacidosis

Search GEO for disease gene expression data for Diabetic Ketoacidosis.

Pathways for genes affiliated with Diabetic Ketoacidosis

Sources:
54Reactome, 12EMD Millipore, 30KEGG, 38NCBI BioSystems Database, 50PharmGKB, 4Cell Signaling Technology, 52QIAGEN
See all sources

Compounds for genes affiliated with Diabetic Ketoacidosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.6ADRB3, CHKB
2oxygen45 2411.2ADRB3, TPO, GAD1, PIK3C2A
3gemfibrozil45 29 1112.2G6PD, PIK3C2A, INS, CHKB
4hydrocortisone45 2 60 1113.2LSL, INS, AQP2, TPO
5dexamethasone45 50 29 1113.2CTLA4, INS, ADRB3, AQP2, HNF4A
6streptozotocin4510.2INS, SST, AGER, GAD1
7beta-hydroxybutyrate4510.1CHKB, INS, LSL
8bezafibrate45 29 1112.1HNF4A, PIK3C2A, CHKB, INS
9uric acid45 2411.1TPO, ADRB3, PIK3C2A, G6PD, CHKB
10olanzapine50 45 29 11 2414.1ADRB3, INS, CHKB, LSL
11methimazole45 2 1112.1IL18, LSL, TPO, G6PD
12malondialdehyde4510.0LSL, G6PD, CHKB, PIK3C2A, AGER
13acipimox45 2911.0LSL, INS, SST
14choline45 11 2412.0PIK3C2A, SST, CHKB, GAD1, GAD2
15acetylcholine45 50 29 11 2414.0CTLA4, IL18, TPO, SST, GAD1, GAD2
16prednisolone45 29 1112.0LSL, IL18, CHKB, PIK3C2A, GAD1
17potassium45 11 2412.0GAD1, ADRB3, TPO, AQP2, PIK3C2A, TNNI3
18hydrogen45 2411.0HNF4A, GAD1, CHKB, LSL, TPO, AQP2
19fatty acid459.9CHKB, LSL, BTD, HNF4A, PIK3C2A
20urea45 11 2411.9PIK3C2A, HNF4A, LSL, CHKB, ADRB3, AQP2
21cyclosporin a45 29 6011.8GAD1, PIK3C2A, CTLA4, AQP2, IL18, GAD2
22lithium45 50 11 2412.8TPO, AQP2, LSL, HNF4A
23acth459.8TPO, SST, INS, PIK3C2A, LSL
24glycerol45 11 2411.8LSL, AQP2, CHKB, INS, PIK3C2A, G6PD
25glycogen45 2410.8HNF4A, PIK3C2A, CHKB, BTD, INS, ADRB3
26thyroxine45 2410.8SST, TPO, INS, CHKB, LSL, G6PD
27fibrinogen459.8CHKB, TPO, IL18, INS, LSL, PIK3C2A
28c-peptide459.7GAD2, SST, GAD1, HNF4A, ADRB3, INS
29adenylate459.7G6PD, ADRB3, CHKB, TPO, AQP2, IL18
30glucose459.6AQP2, GAD1, GAD2, HNF4A, PAX4, PIK3C2A
31aspartate459.5G6PD, PIK3C2A, GAD1, HLA-DQB1, CHKB, LSL
32cysteine459.5AQP2, CHKB, BTD, GAD1, TPO, IL18
33epinephrine45 11 2411.5CHKB, G6PD, LSL, SST, PIK3C2A, ADRB3
34lactate459.5INS, LSL, IL18, G6PD, PIK3C2A, TNNI3
35atp45 2910.5GAD2, CHKB, G6PD, HNF4A, ADRB3, AQP2
36steroid459.4GAD1, TPO, HNF4A, IL18, CHKB, LSL
37glutamine459.4G6PD, IL18, CHKB, HNF4A, GAD1, HLA-DQB1
38estrogen459.4CHKB, G6PD, CTLA4, HNF4A, LSL, IL18
39oligonucleotide459.4GAD1, HLA-DQB1, GAD2, HNF4A, CLDN5, TPO
40testosterone45 60 11 2412.4PIK3C2A, SST, INS, IL18, TPO, HNF4A
41nitric oxide45 11 2411.4AGER, GAD2, LSL, GAD1, IL18, TPO
42methotrexate45 50 1111.3CHKB, IL18, LSL, CTLA4, PIK3C2A
43alanine459.3HNF4A, AQP2, CTLA4, INS, ADRB3, CHKB
44creatinine459.2IL18, INS, CHKB, AGER, TPO, GAD1
45glutamate459.2TPO, IL18, INS, SST, PIK3C2A, HLA-DQB1
46tyrosine459.2PIK3C2A, HLA-DQB1, GAD1, GAD2, CTLA4, AGER
47lipid459.2ADRB3, G6PD, IL18, HNF4A, PIK3C2A, CTLA4
48cholesterol45 29 11 2412.1HNF4A, LSL, CTLA4, GAD2, AGER, CHKB
49arginine459.0CHKB, INS, IL18, AQP2, TPO, BTD
50calcium45 50 11 2411.8HNF4A, IL18, TPO, AQP2, CLDN5, CHKB

GO Terms for genes affiliated with Diabetic Ketoacidosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.9GAD2, GAD1
2plasma membraneGO:0058868.9CTLA4, GAD2, GAD1, HLA-DQB1, PIK3C2A, AGER

Biological processes related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.2GAD1, GAD2
2response to drugGO:04249310.0PAX4, SST, GAD1, GAD2
3endocrine pancreas developmentGO:03101810.0PAX4, INS, HNF4A
4hyperosmotic responseGO:0069729.9SST, AQP2

Molecular functions related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate bindingGO:01659510.2GAD1, GAD2
2glutamate decarboxylase activityGO:0043519.9GAD1, GAD2

Products for genes affiliated with Diabetic Ketoacidosis

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  • Proteins
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Sources for Diabetic Ketoacidosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet