MCID: DBT001
MIFTS: 52

Diabetic Ketoacidosis malady

Summaries for Diabetic Ketoacidosis

About this section


Wikipedia:63 Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes... more...

MalaCards based summary: Diabetic Ketoacidosis, also known as diabetes mellitus, insulin-dependent, is related to hypokalemia and hypoglycemia. An important gene associated with Diabetic Ketoacidosis is INS (insulin), and among its related pathways are Cardiac Progenitor Differentiation and Alanine, aspartate and glutamate metabolism. The drugs insulin and insulin, aspart, human and the compounds streptozotocin and 2-deoxyglucose have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and heart, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Diabetic Ketoacidosis

About this section
Sources:
9Disease Ontology, 60UMLS, 43Novoseek, 27ICD9CM, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Diabetic Ketoacidosis, Aliases & Descriptions:

Name: Diabetic Ketoacidosis 9 43 60
Diabetes Mellitus, Insulin-Dependent 60
 
Diabetes Mellitus, Ketosis-Prone 9
Ketosis-Prone Diabetes Mellitus 9


External Ids:

Disease Ontology9 DOID:1837
ICD9CM27 250.1
MeSH33 D016883
NCIt38 C50530

Related Diseases for Diabetic Ketoacidosis

About this section

Graphical network of the top 20 diseases related to Diabetic Ketoacidosis:



Diseases related to diabetic ketoacidosis

Symptoms for Diabetic Ketoacidosis

About this section

Genetic Tests for Diabetic Ketoacidosis

About this section

Anatomical Context for Diabetic Ketoacidosis

About this section

MalaCards organs/tissues related to Diabetic Ketoacidosis:

31
Testes, Brain, Heart, Pituitary, Thyroid, Bone, Spinal cord, Small intestine, Kidney, Liver, Endothelial, Pancreatic islet

Animal Models for Diabetic Ketoacidosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Diabetic Ketoacidosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5INS, GAD1, GAD2, CTLA4
2MP:00028738.5CTLA4, GAD2, GAD1, INS
3MP:00053888.4CTLA4, GAD2, GAD1, TNNI3
4MP:00053798.2INS, GAD1, GAD2, CTLA4
5MP:00053867.8INS, TNNI3, AQP2, GAD1, GAD2
6MP:00053767.5CTLA4, GAD2, GAD1, AQP2, INS
7MP:00107687.3CTLA4, GAD2, GAD1, AQP2, TNNI3, INS

Publications for Diabetic Ketoacidosis

About this section

Articles related to Diabetic Ketoacidosis:

(show top 50)    (show all 639)
idTitleAuthorsYear
1
Fluid management in pediatric patients with diabetic ketoacidosis and rates of suspected clinical cerebral edema. (25800410)
2015
2
Improving care for pediatric diabetic ketoacidosis. (25092935)
2014
3
Sudden death of a 15-year-old girl due to fulminant type 1 diabetes mellitus-diabetic ketoacidosis induced cerebral edema? (25066164)
2014
4
Insulin therapy for the management of diabetic ketoacidosis: time for a paradigm shift? (25264783)
2014
5
Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. (24362895)
2013
6
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent. (23729615)
2013
7
Possibility to reduce mortality in diabetic ketoacidosis. (23931740)
2013
8
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
9
Increasing use of hypertonic saline over mannitol in the treatment of symptomatic cerebral edema in pediatric diabetic ketoacidosis: an 11-year retrospective analysis of mortality*. (23863818)
2013
10
Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. (23075084)
2013
11
Spontaneous Pneumomediastinum in a Patient With Diabetic Ketoacidosis. (24139747)
2013
12
The role of the Armanni-Ebstein lesion, hepatic steatosis, biochemical analysis and second generation anti-psychotic drugs in fatal diabetic ketoacidosis. (23357396)
2013
13
Hypertension in severe pediatric diabetic ketoacidosis: case report and review of literature. (23283273)
2013
14
Deep vein thrombosis and pulmonary embolism in a child with diabetic ketoacidosis and protein s deficiency: a case report. (23306559)
2013
15
Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis. (23737516)
2013
16
Intracranial pressure/cerebral perfusion pressure-targeted management of life-threatening intracranial hypertension complicating diabetic ketoacidosis-associated cerebral edema: a case report. (22766587)
2012
17
The role of point-of-care I^-hydroxybutyrate testing in the diagnosis of diabetic ketoacidosis: a review. (22615081)
2012
18
Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. (21475607)
2011
19
Management of diabetic ketoacidosis. (21526698)
2011
20
Diagnostic approach to drug-screening tests for fatal diabetic ketoacidosis: forensic autopsy of a methamphetamine abuser. (20444635)
2010
21
Utility of initial bolus insulin in the treatment of diabetic ketoacidosis. (18514472)
2010
22
Passing the acid test. What you need to know about diabetic ketoacidosis. (20405612)
2010
23
Fatal massive cerebral infarctions in a young patient with diabetic ketoacidosis--a rare case of atherosclerotic moyamoya disease. (19917648)
2010
24
The performance of a glucose-ketone meter in the diagnosis of diabetic ketoacidosis in patients with type 2 diabetes in the emergency room. (20597827)
2010
25
Neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report. (21274328)
2010
26
Two cases of type 1 diabetic women with diabetic ketoacidosis presenting as alkalaemia. (19117632)
2009
27
Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. (19667310)
2009
28
Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis. (20016359)
2009
29
Diabetic ketoacidosis in children and adolescents with diabetes. (19754623)
2009
30
New-onset diabetes mellitus presenting with diabetic ketoacidosis after pediatric liver transplantation. (19207220)
2009
31
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
32
Diabetic ketoacidosis, respiratory distress and myocardial dysfunction. (22132021)
2009
33
Incidence of Diabetic Ketoacidosis during Ramadan Fasting in Benghazi-Libya. (22334853)
2009
34
Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. (18547233)
2008
35
Diabetic ketoacidosis: the usual villain or a scapegoat? A novel cause of severe metabolic acidosis in type 1 diabetes. (18308676)
2008
36
Management of diabetic ketoacidosis in children and adolescents. (19047433)
2008
37
A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. (18651203)
2008
38
Insulin in special situations: diabetic ketoacidosis. (17927011)
2007
39
Euglycemic diabetic ketoacidosis in pregnancy. (17951948)
2007
40
Diabetic ketoacidosis: principles of management. (17953311)
2007
41
Spontaneous pneumorrhachis associated with pneumomediastinum in a patient with diabetic ketoacidosis: an exceptional manifestation of a benign disease. (17568499)
2007
42
Severe hypernatremia and hyperosmolality exacerbated by an herbal preparation in a patient with diabetic ketoacidosis. (17585008)
2007
43
Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. (15336577)
2004
44
Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. (12668546)
2003
45
Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis. (14976569)
2003
46
Association between diabetic ketoacidosis and thyrotoxicosis. (12486499)
2002
47
Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. (9283776)
1997
48
Recent advances in management of diabetic ketoacidosis. (10771810)
1997
49
Insulin-dependent diabetes mellitus presenting as diabetic ketoacidosis in pregnancy. (8546655)
1995
50
Diabetic ketoacidosis in pregnancy resulting from insulin pump failure. A case report. (8501740)
1993

Variations for Diabetic Ketoacidosis

About this section

Expression for genes affiliated with Diabetic Ketoacidosis

About this section
Search GEO for disease gene expression data for Diabetic Ketoacidosis.

Pathways for genes affiliated with Diabetic Ketoacidosis

About this section

Pathways related to Diabetic Ketoacidosis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNNI3, INS
29.4GAD2, GAD1
3
Show member pathways
9.4GAD1, GAD2
4
Show member pathways
phenylethylamine degradation I36
9.4GAD2, GAD1
5
Show member pathways
9.4GAD2, GAD1
6
Show member pathways
9.4GAD2, GAD1
7
Show member pathways
9.4GAD2, GAD1
8
Show member pathways
catecholamine biosynthesis36
9.4GAD1, GAD2
99.4GAD1, GAD2
108.6GAD2, AQP2, INS
11
Show member pathways
8.5CTLA4, GAD2, GAD1, INS

Compounds for genes affiliated with Diabetic Ketoacidosis

About this section

Compounds related to Diabetic Ketoacidosis according to GeneCards Suite gene sharing:

(show all 45)
idCompoundScoreTop Affiliating Genes
1streptozotocin4310.0GAD1, INS
22-deoxyglucose43 1210.9GAD1, INS
3Cysteic acid249.8GAD2, GAD1
4cysteine sulfinic acid439.8GAD2, GAD1
5hypotaurine59 43 2411.8GAD2, GAD1
63-Sulfinoalanine24 1210.8GAD2, GAD1
7pyridoxal43 24 1211.8GAD2, GAD1
8L-Aspartic acid24 1210.8GAD2, GAD1
9beta-alanine43 59 28 24 1213.8GAD1, GAD2
10Gamma-Aminobutyric acid249.8GAD2, GAD1
11taurine43 59 2411.8GAD1, GAD2
12pyridoxal 5-phosphate439.7GAD2, GAD1
13famotidine43 2 24 1212.7GAD2, GAD1
14mptp439.7GAD1, GAD2
15Pyridoxal 5'-phosphate249.7GAD2, GAD1
16tetrodotoxin43 59 2811.7GAD2, GAD1
17l-glutamic acid28 24 1211.7GAD2, GAD1
18levodopa43 1210.7GAD2, GAD1
19carbon dioxide43 2410.6GAD2, GAD1
20kainate43 2810.6GAD2, GAD1
21furosemide43 59 28 49 24 1214.6AQP2, GAD1
22ornithine43 2410.5GAD2, GAD1
23c-peptide439.4GAD2, GAD1, INS
24haloperidol43 49 28 2 1213.4GAD1, AQP2
25acetylcholine43 49 28 24 1213.3CTLA4, GAD2, GAD1
26hydrocortisone43 2 59 1212.1INS, AQP2
27choline43 24 1211.1GAD2, GAD1
28methionine439.1CTLA4, GAD1, AQP2
29potassium43 24 1211.0GAD1, AQP2, TNNI3
30steroid438.9AQP2, GAD1, CTLA4
31dexamethasone43 49 28 1211.9INS, AQP2, CTLA4
32hydrogen43 249.9GAD2, GAD1, AQP2
33arginine438.9INS, AQP2, GAD1
34cholesterol43 28 24 1211.9INS, GAD1, GAD2, CTLA4
35glutamate438.9INS, GAD1, GAD2, CTLA4
36tyrosine438.8INS, GAD1, GAD2, CTLA4
37creatinine438.7INS, TNNI3, AQP2, GAD1
38nitric oxide43 24 1210.6GAD2, GAD1, AQP2
39atp43 289.6GAD2, GAD1, AQP2
40threonine438.5CTLA4, GAD2, AQP2
41cyclosporin a43 28 5910.5AQP2, GAD1, GAD2, CTLA4
42cysteine438.5AQP2, GAD1, GAD2, CTLA4
43alanine438.1CTLA4, GAD2, GAD1, AQP2, INS
44glucose438.1INS, AQP2, GAD1, GAD2, CTLA4
45calcium43 49 24 1210.9TNNI3, AQP2, GAD1, GAD2, CTLA4

GO Terms for genes affiliated with Diabetic Ketoacidosis

About this section

Cellular components related to Diabetic Ketoacidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:00612029.4GAD2, GAD1

Biological processes related to Diabetic Ketoacidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neurotransmitter secretionGO:00072699.4GAD2, GAD1
2glutamate decarboxylation to succinateGO:00065409.3GAD2, GAD1
3neurotransmitter biosynthetic processGO:00421369.1GAD2, GAD1

Molecular functions related to Diabetic Ketoacidosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:00301709.4GAD2, GAD1
2glutamate decarboxylase activityGO:00043519.3GAD2, GAD1
3glutamate bindingGO:00165959.1GAD2, GAD1

Products for genes affiliated with Diabetic Ketoacidosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Diabetic Ketoacidosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet