MCID: DBT001
MIFTS: 66

Diabetic Ketoacidosis malady

Metabolic diseases category
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Summaries for Diabetic Ketoacidosis

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Wikipedia:65 Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes... more...

MalaCards based summary: Diabetic Ketoacidosis, also known as diabetes mellitus, ketosis-prone, is related to hypoglycemia and hypokalemia, and has symptoms including An important gene associated with Diabetic Ketoacidosis is PAX4 (paired box 4), and among its related pathways are Regulation of beta-cell development and Alanine, aspartate and glutamate metabolism. The drugs insulin and insulin, aspart, human and the compounds repaglinide and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related mouse phenotypes are behavior/neurological and digestive/alimentary.

Description from OMIM:46 612227

Aliases & Classifications for Diabetic Ketoacidosis

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 9diseasecard, 46OMIM, 22GTR, 34MeSH, 57SNOMED-CT, 39NCIt, 27ICD9CM
See all sources

Diabetic Ketoacidosis, Aliases & Descriptions:

Name: Diabetic Ketoacidosis 8 44 62
Diabetes Mellitus, Ketosis-Prone 8 9 46
 
Ketosis-Prone Diabetes Mellitus 8 22
Diabetes Mellitus, Insulin-Dependent 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology8 DOID:1837
MeSH34 D016883
NCIt39 C50530
ICD9CM27 250.1
OMIM46 612227

Related Diseases for Diabetic Ketoacidosis

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Graphical network of the top 20 diseases related to Diabetic Ketoacidosis:



Diseases related to diabetic ketoacidosis

Symptoms for Diabetic Ketoacidosis

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Symptoms by clinical synopsis from OMIM:

612227

Clinical features from OMIM:

612227

HPO human phenotypes related to Diabetic Ketoacidosis:

id Description Frequency HPO Source Accession
1 insulin resistance HP:0000855
2 multifactorial inheritance HP:0001426
3 ketoacidosis HP:0001993
4 autoimmunity HP:0002960
5 beta-cell dysfunction HP:0006279

Genetic Tests for Diabetic Ketoacidosis

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Genetic tests related to Diabetic Ketoacidosis:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Ketosis-Prone22

Anatomical Context for Diabetic Ketoacidosis

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MalaCards organs/tissues related to Diabetic Ketoacidosis:

32
Brain, Testes, Heart, Pituitary, Thyroid, Bone, Spinal cord, Small intestine, Kidney, Liver, Endothelial, Pancreatic islet

Animal Models for Diabetic Ketoacidosis or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Ketoacidosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2GAD2, GAD1, AQP2, INS
2MP:00053818.1INS, GAD1, GAD2, CTLA4
3MP:00053797.8CTLA4, GAD2, GAD1, PAX4, INS
4MP:00028737.8INS, PAX4, GAD1, GAD2, CTLA4
5MP:00053787.6GAD2, GAD1, PAX4, AQP2, INS
6MP:00053767.2INS, AQP2, GAD1, GAD2, CTLA4
7MP:00107687.2INS, AQP2, PAX4, GAD1, GAD2, CTLA4

Publications for Diabetic Ketoacidosis

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Articles related to Diabetic Ketoacidosis:

(show top 50)    (show all 614)
idTitleAuthorsYear
1
Improving care for pediatric diabetic ketoacidosis. (25092935)
2014
2
Sudden death of a 15-year-old girl due to fulminant type 1 diabetes mellitus-diabetic ketoacidosis induced cerebral edema? (25066164)
2014
3
Insulin therapy for the management of diabetic ketoacidosis: time for a paradigm shift? (25264783)
2014
4
Effect of normal saline and half normal saline on serum electrolytes during recovery phase of diabetic ketoacidosis. (23753222)
2014
5
Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. (24362895)
2013
6
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent. (23729615)
2013
7
Possibility to reduce mortality in diabetic ketoacidosis. (23931740)
2013
8
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
9
Increasing use of hypertonic saline over mannitol in the treatment of symptomatic cerebral edema in pediatric diabetic ketoacidosis: an 11-year retrospective analysis of mortality*. (23863818)
2013
10
Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. (23075084)
2013
11
Spontaneous Pneumomediastinum in a Patient With Diabetic Ketoacidosis. (24139747)
2013
12
The role of the Armanni-Ebstein lesion, hepatic steatosis, biochemical analysis and second generation anti-psychotic drugs in fatal diabetic ketoacidosis. (23357396)
2013
13
Hypertension in severe pediatric diabetic ketoacidosis: case report and review of literature. (23283273)
2013
14
Deep vein thrombosis and pulmonary embolism in a child with diabetic ketoacidosis and protein s deficiency: a case report. (23306559)
2013
15
Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis. (23737516)
2013
16
Intracranial pressure/cerebral perfusion pressure-targeted management of life-threatening intracranial hypertension complicating diabetic ketoacidosis-associated cerebral edema: a case report. (22766587)
2012
17
The role of point-of-care I^-hydroxybutyrate testing in the diagnosis of diabetic ketoacidosis: a review. (22615081)
2012
18
Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. (21475607)
2011
19
Management of diabetic ketoacidosis. (21526698)
2011
20
Diagnostic approach to drug-screening tests for fatal diabetic ketoacidosis: forensic autopsy of a methamphetamine abuser. (20444635)
2010
21
Utility of initial bolus insulin in the treatment of diabetic ketoacidosis. (18514472)
2010
22
Passing the acid test. What you need to know about diabetic ketoacidosis. (20405612)
2010
23
Fatal massive cerebral infarctions in a young patient with diabetic ketoacidosis--a rare case of atherosclerotic moyamoya disease. (19917648)
2010
24
The performance of a glucose-ketone meter in the diagnosis of diabetic ketoacidosis in patients with type 2 diabetes in the emergency room. (20597827)
2010
25
Neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report. (21274328)
2010
26
Two cases of type 1 diabetic women with diabetic ketoacidosis presenting as alkalaemia. (19117632)
2009
27
Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. (19667310)
2009
28
Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis. (20016359)
2009
29
Diabetic ketoacidosis in children and adolescents with diabetes. (19754623)
2009
30
New-onset diabetes mellitus presenting with diabetic ketoacidosis after pediatric liver transplantation. (19207220)
2009
31
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
32
Diabetic ketoacidosis, respiratory distress and myocardial dysfunction. (22132021)
2009
33
Incidence of Diabetic Ketoacidosis during Ramadan Fasting in Benghazi-Libya. (22334853)
2009
34
Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. (18547233)
2008
35
Diabetic ketoacidosis: the usual villain or a scapegoat? A novel cause of severe metabolic acidosis in type 1 diabetes. (18308676)
2008
36
Management of diabetic ketoacidosis in children and adolescents. (19047433)
2008
37
A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. (18651203)
2008
38
Insulin in special situations: diabetic ketoacidosis. (17927011)
2007
39
Euglycemic diabetic ketoacidosis in pregnancy. (17951948)
2007
40
Diabetic ketoacidosis: principles of management. (17953311)
2007
41
Spontaneous pneumorrhachis associated with pneumomediastinum in a patient with diabetic ketoacidosis: an exceptional manifestation of a benign disease. (17568499)
2007
42
Severe hypernatremia and hyperosmolality exacerbated by an herbal preparation in a patient with diabetic ketoacidosis. (17585008)
2007
43
Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. (15336577)
2004
44
Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. (12668546)
2003
45
Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis. (14976569)
2003
46
Association between diabetic ketoacidosis and thyrotoxicosis. (12486499)
2002
47
Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. (9283776)
1997
48
Recent advances in management of diabetic ketoacidosis. (10771810)
1997
49
Insulin-dependent diabetes mellitus presenting as diabetic ketoacidosis in pregnancy. (8546655)
1995
50
Diabetic ketoacidosis in pregnancy resulting from insulin pump failure. A case report. (8501740)
1993

Variations for Diabetic Ketoacidosis

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Expression for genes affiliated with Diabetic Ketoacidosis

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Expression patterns in normal tissues for genes affiliated with Diabetic Ketoacidosis

Search GEO for disease gene expression data for Diabetic Ketoacidosis.

Pathways for genes affiliated with Diabetic Ketoacidosis

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Pathways related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6INS, PAX4
29.1GAD2, GAD1
3
Show member pathways
9.1GAD2, GAD1
4
Show member pathways
9.1GAD2, GAD1
5
Show member pathways
9.1GAD2, GAD1
6
Show member pathways
phenylethylamine degradation I37
9.1GAD2, GAD1
7
Show member pathways
9.1GAD2, GAD1
8
Show member pathways
9.1GAD2, GAD1
9
Show member pathways
9.1GAD2, GAD1
10
Show member pathways
catecholamine biosynthesis37
9.1GAD1, GAD2
119.1GAD1, GAD2
128.7GAD2, AQP2, INS
13
Show member pathways
8.1CTLA4, GAD2, GAD1, INS

Compounds for genes affiliated with Diabetic Ketoacidosis

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Compounds related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1repaglinide50 44 1112.0PAX4, INS
2streptozotocin449.9GAD1, INS
32-deoxyglucose44 1110.8INS, GAD1
4furosemide44 61 28 50 24 1114.8AQP2, GAD1
5haloperidol44 50 28 2 1113.7GAD1, AQP2
6Cysteic acid249.6GAD2, GAD1
7cysteine sulfinic acid449.6GAD1, GAD2
8hypotaurine61 44 2411.6GAD2, GAD1
93-Sulfinoalanine24 1110.6GAD2, GAD1
10pyridoxal44 24 1111.5GAD2, GAD1
11L-Aspartic acid24 1110.5GAD2, GAD1
12beta-alanine44 61 28 24 1113.5GAD2, GAD1
13Gamma-Aminobutyric acid249.5GAD1, GAD2
14taurine44 61 2411.5GAD2, GAD1
15pyridoxal 5-phosphate449.5GAD2, GAD1
16famotidine44 2 24 1112.5GAD2, GAD1
17mptp449.5GAD1, GAD2
18Pyridoxal 5'-phosphate249.5GAD2, GAD1
19tetrodotoxin44 61 2811.4GAD2, GAD1
20l-glutamic acid28 24 1111.4GAD1, GAD2
21levodopa44 1110.4GAD2, GAD1
22hydrocortisone44 2 61 1112.4AQP2, INS
23carbon dioxide44 2410.4GAD1, GAD2
24kainate44 2810.3GAD1, GAD2
25creatinine449.3GAD1, AQP2, INS
26ornithine44 2410.3GAD2, GAD1
27methionine449.2AQP2, GAD1, CTLA4
28arginine449.1GAD1, AQP2, INS
29dexamethasone44 50 28 1112.1CTLA4, AQP2, INS
30c-peptide449.1GAD2, GAD1, INS
31steroid449.1CTLA4, GAD1, AQP2
32hydrogen44 2410.0GAD2, GAD1, AQP2
33acetylcholine44 50 28 24 1112.9CTLA4, GAD2, GAD1
34choline44 24 1110.8GAD2, GAD1
35nitric oxide44 24 1110.7AQP2, GAD1, GAD2
36atp44 289.6GAD2, GAD1, AQP2
37threonine448.6CTLA4, GAD2, AQP2
38cholesterol44 28 24 1111.5INS, GAD1, GAD2, CTLA4
39glutamate448.5INS, GAD1, GAD2, CTLA4
40cyclosporin a44 28 6110.4AQP2, GAD1, GAD2, CTLA4
41cysteine448.4AQP2, GAD1, GAD2, CTLA4
42tyrosine448.4CTLA4, GAD2, GAD1, INS
43calcium44 50 24 1111.0AQP2, GAD1, GAD2, CTLA4
44alanine448.0INS, AQP2, GAD1, GAD2, CTLA4
45glucose447.6CTLA4, GAD2, GAD1, PAX4, AQP2, INS

GO Terms for genes affiliated with Diabetic Ketoacidosis

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Cellular components related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.1GAD2, GAD1

Biological processes related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell differentiationGO:0455979.5INS, PAX4
2endocrine pancreas developmentGO:0310189.3PAX4, INS
3glutamate decarboxylation to succinateGO:0065409.2GAD2, GAD1
4neurotransmitter biosynthetic processGO:0421369.2GAD2, GAD1
5neurotransmitter secretionGO:0072699.1GAD2, GAD1
6response to drugGO:0424938.7PAX4, GAD1, GAD2

Molecular functions related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:0301709.1GAD2, GAD1
2glutamate decarboxylase activityGO:0043519.0GAD2, GAD1
3glutamate bindingGO:0165958.8GAD2, GAD1

Products for genes affiliated with Diabetic Ketoacidosis

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  • Antibodies
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Sources for Diabetic Ketoacidosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet