MCID: DBT001
MIFTS: 65

Diabetic Ketoacidosis malady

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Summaries for Diabetic Ketoacidosis

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes... more...

MalaCards: Diabetic Ketoacidosis, also known as diabetes mellitus, ketosis-prone, is related to diabetes mellitus and type 1 diabetes mellitus. An important gene associated with Diabetic Ketoacidosis is PAX4 (paired box 4), and among its related pathways are Regulation of beta-cell development and Alanine, aspartate and glutamate metabolism. The drugs insulin and insulin, aspart, human and the compounds repaglinide and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are behavior/neurological and digestive/alimentary.

Description from OMIM:47 612227

Aliases & Classifications for Diabetic Ketoacidosis

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8Disease Ontology, 45Novoseek, 62UMLS, 9diseasecard, 47OMIM, 22GTR, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

diabetic ketoacidosis 8 45 62
diabetes mellitus, ketosis-prone 8 9 47
ketosis-prone diabetes mellitus 8 22
diabetes mellitus, insulin-dependent 62


External Ids:

Disease Ontology8 DOID:1837
NCIt40 C50530
ICD9CM27 250.1
MeSH35 D016883
OMIM47 612227

Related Diseases for Diabetic Ketoacidosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Diabetic Ketoacidosis:



Diseases related to diabetic ketoacidosis

Symptoms for Diabetic Ketoacidosis

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47OMIM
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Symptoms by clinical synopsis from OMIM:

612227

Clinical features from OMIM:

612227

Genetic Tests for Diabetic Ketoacidosis

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22GTR
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Genetic tests related to Diabetic Ketoacidosis:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Ketosis-Prone22

Anatomical Context for Diabetic Ketoacidosis

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33MalaCards
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MalaCards organs/tissues related to Diabetic Ketoacidosis:

33
Brain, Testes, Pituitary, Heart, Thyroid, Bone, Spinal cord, Endothelial, Small intestine, Pancreatic islet, Liver

Animal Models for Diabetic Ketoacidosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Diabetic Ketoacidosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2GAD2, GAD1, AQP2, INS
2MP:00053818.1INS, GAD1, GAD2, CTLA4
3MP:00053797.8CTLA4, GAD2, GAD1, PAX4, INS
4MP:00028737.8INS, PAX4, GAD1, GAD2, CTLA4
5MP:00053787.6GAD2, GAD1, PAX4, AQP2, INS
6MP:00053767.2INS, AQP2, GAD1, GAD2, CTLA4
7MP:00107687.2INS, AQP2, PAX4, GAD1, GAD2, CTLA4

Publications for Diabetic Ketoacidosis

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52PubMed
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Articles related to Diabetic Ketoacidosis:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Effect of normal saline and half normal saline on serum electrolytes during recovery phase of diabetic ketoacidosis. (23753222)
2014
2
Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. (24362895)
2013
3
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent. (23729615)
2013
4
Possibility to reduce mortality in diabetic ketoacidosis. (23931740)
2013
5
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
6
Increasing use of hypertonic saline over mannitol in the treatment of symptomatic cerebral edema in pediatric diabetic ketoacidosis: an 11-year retrospective analysis of mortality*. (23863818)
2013
7
Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. (23075084)
2013
8
Spontaneous Pneumomediastinum in a Patient With Diabetic Ketoacidosis. (24139747)
2013
9
The role of the Armanni-Ebstein lesion, hepatic steatosis, biochemical analysis and second generation anti-psychotic drugs in fatal diabetic ketoacidosis. (23357396)
2013
10
Hypertension in severe pediatric diabetic ketoacidosis: case report and review of literature. (23283273)
2013
11
Deep vein thrombosis and pulmonary embolism in a child with diabetic ketoacidosis and protein s deficiency: a case report. (23306559)
2013
12
Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis. (23737516)
2013
13
Intracranial pressure/cerebral perfusion pressure-targeted management of life-threatening intracranial hypertension complicating diabetic ketoacidosis-associated cerebral edema: a case report. (22766587)
2012
14
The role of point-of-care I^-hydroxybutyrate testing in the diagnosis of diabetic ketoacidosis: a review. (22615081)
2012
15
Polyglandular autoimmune syndrome (PGA)--type 2 with diabetic ketoacidosis. (22009276)
2012
16
Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. (21475607)
2011
17
Management of diabetic ketoacidosis. (21526698)
2011
18
Diagnostic approach to drug-screening tests for fatal diabetic ketoacidosis: forensic autopsy of a methamphetamine abuser. (20444635)
2010
19
Utility of initial bolus insulin in the treatment of diabetic ketoacidosis. (18514472)
2010
20
Passing the acid test. What you need to know about diabetic ketoacidosis. (20405612)
2010
21
Fatal massive cerebral infarctions in a young patient with diabetic ketoacidosis--a rare case of atherosclerotic moyamoya disease. (19917648)
2010
22
The performance of a glucose-ketone meter in the diagnosis of diabetic ketoacidosis in patients with type 2 diabetes in the emergency room. (20597827)
2010
23
Neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report. (21274328)
2010
24
Two cases of type 1 diabetic women with diabetic ketoacidosis presenting as alkalaemia. (19117632)
2009
25
Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. (19667310)
2009
26
Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis. (20016359)
2009
27
Diabetic ketoacidosis in children and adolescents with diabetes. (19754623)
2009
28
New-onset diabetes mellitus presenting with diabetic ketoacidosis after pediatric liver transplantation. (19207220)
2009
29
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
30
Diabetic ketoacidosis, respiratory distress and myocardial dysfunction. (22132021)
2009
31
Incidence of Diabetic Ketoacidosis during Ramadan Fasting in Benghazi-Libya. (22334853)
2009
32
Evaluating the safety and efficacy of Glucommander, a computer-based insulin infusion method, in management of diabetic ketoacidosis in children, and comparing its clinical performance with manually titrated insulin infusion. (19449669)
2009
33
Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. (18547233)
2008
34
Diabetic ketoacidosis: the usual villain or a scapegoat? A novel cause of severe metabolic acidosis in type 1 diabetes. (18308676)
2008
35
Management of diabetic ketoacidosis in children and adolescents. (19047433)
2008
36
A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. (18651203)
2008
37
Insulin in special situations: diabetic ketoacidosis. (17927011)
2007
38
Euglycemic diabetic ketoacidosis in pregnancy. (17951948)
2007
39
Diabetic ketoacidosis: principles of management. (17953311)
2007
40
Spontaneous pneumorrhachis associated with pneumomediastinum in a patient with diabetic ketoacidosis: an exceptional manifestation of a benign disease. (17568499)
2007
41
Severe hypernatremia and hyperosmolality exacerbated by an herbal preparation in a patient with diabetic ketoacidosis. (17585008)
2007
42
Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. (15336577)
2004
43
Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. (12668546)
2003
44
Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis. (14976569)
2003
45
Association between diabetic ketoacidosis and thyrotoxicosis. (12486499)
2002
46
Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. (9283776)
1997
47
Recent advances in management of diabetic ketoacidosis. (10771810)
1997
48
Insulin-dependent diabetes mellitus presenting as diabetic ketoacidosis in pregnancy. (8546655)
1995
49
Diabetic ketoacidosis in pregnancy resulting from insulin pump failure. A case report. (8501740)
1993
50
Malignant somatostatinoma presenting with diabetic ketoacidosis. (2822297)
1987

Variations for Diabetic Ketoacidosis

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Expression for genes affiliated with Diabetic Ketoacidosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Ketoacidosis

Search GEO for disease gene expression data for Diabetic Ketoacidosis.

Pathways for genes affiliated with Diabetic Ketoacidosis

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54R&D Systems, 60Thomson Reuters, 5Cell Signaling Technology, 53QIAGEN
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Pathways related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6INS, PAX4
29.1GAD2, GAD1
3
Show member pathways
9.1GAD2, GAD1
4
Show member pathways
9.1GAD2, GAD1
5
Show member pathways
9.1GAD2, GAD1
6
Show member pathways
phenylethylamine degradation I38
9.1GAD2, GAD1
7
Show member pathways
9.1GAD2, GAD1
8
Show member pathways
9.1GAD2, GAD1
9
Show member pathways
9.1GAD2, GAD1
10
Show member pathways
catecholamine biosynthesis38
9.1GAD1, GAD2
119.1GAD1, GAD2
128.7GAD2, AQP2, INS
13
Show member pathways
8.1CTLA4, GAD2, GAD1, INS

Compounds for genes affiliated with Diabetic Ketoacidosis

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Sources:
51PharmGKB, 45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1repaglinide51 45 1112.0PAX4, INS
2streptozotocin459.9GAD1, INS
32-deoxyglucose45 1110.8INS, GAD1
4furosemide45 61 29 51 24 1114.8AQP2, GAD1
5haloperidol45 51 29 3 1113.7GAD1, AQP2
6Cysteic acid249.6GAD2, GAD1
7cysteine sulfinic acid459.6GAD1, GAD2
8hypotaurine61 45 2411.6GAD2, GAD1
93-Sulfinoalanine24 1110.6GAD2, GAD1
10pyridoxal45 24 1111.5GAD2, GAD1
11L-Aspartic acid24 1110.5GAD2, GAD1
12beta-alanine45 61 29 24 1113.5GAD2, GAD1
13Gamma-Aminobutyric acid249.5GAD1, GAD2
14taurine45 61 2411.5GAD2, GAD1
15pyridoxal 5-phosphate459.5GAD2, GAD1
16famotidine45 3 24 1112.5GAD2, GAD1
17mptp459.5GAD1, GAD2
18Pyridoxal 5'-phosphate249.5GAD2, GAD1
19tetrodotoxin45 61 2911.4GAD2, GAD1
20l-glutamic acid29 24 1111.4GAD1, GAD2
21levodopa45 1110.4GAD2, GAD1
22hydrocortisone45 3 61 1112.4AQP2, INS
23carbon dioxide45 2410.4GAD1, GAD2
24kainate45 2910.3GAD1, GAD2
25creatinine459.3GAD1, AQP2, INS
26ornithine45 2410.3GAD2, GAD1
27methionine459.2AQP2, GAD1, CTLA4
28arginine459.1GAD1, AQP2, INS
29dexamethasone45 51 29 1112.1CTLA4, AQP2, INS
30c-peptide459.1GAD2, GAD1, INS
31steroid459.1CTLA4, GAD1, AQP2
32hydrogen45 2410.0GAD2, GAD1, AQP2
33acetylcholine45 51 29 24 1112.9CTLA4, GAD2, GAD1
34choline45 24 1110.8GAD2, GAD1
35nitric oxide45 24 1110.7AQP2, GAD1, GAD2
36atp45 299.6GAD2, GAD1, AQP2
37threonine458.6CTLA4, GAD2, AQP2
38cholesterol45 29 24 1111.5INS, GAD1, GAD2, CTLA4
39glutamate458.5INS, GAD1, GAD2, CTLA4
40cyclosporin a45 29 6110.4AQP2, GAD1, GAD2, CTLA4
41cysteine458.4AQP2, GAD1, GAD2, CTLA4
42tyrosine458.4CTLA4, GAD2, GAD1, INS
43calcium45 51 24 1111.0AQP2, GAD1, GAD2, CTLA4
44alanine458.0INS, AQP2, GAD1, GAD2, CTLA4
45glucose457.6CTLA4, GAD2, GAD1, PAX4, AQP2, INS

GO Terms for genes affiliated with Diabetic Ketoacidosis

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16Gene Ontology
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Cellular components related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.1GAD2, GAD1

Biological processes related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell differentiationGO:0455979.5INS, PAX4
2endocrine pancreas developmentGO:0310189.3PAX4, INS
3glutamate decarboxylation to succinateGO:0065409.2GAD2, GAD1
4neurotransmitter biosynthetic processGO:0421369.2GAD2, GAD1
5neurotransmitter secretionGO:0072699.1GAD2, GAD1
6response to drugGO:0424938.7PAX4, GAD1, GAD2

Molecular functions related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:0301709.1GAD2, GAD1
2glutamate decarboxylase activityGO:0043519.0GAD2, GAD1
3glutamate bindingGO:0165958.8GAD2, GAD1

Products for genes affiliated with Diabetic Ketoacidosis

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  • Antibodies
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Sources for Diabetic Ketoacidosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet