Diabetic Ketoacidosis malady

Wikipedia: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes...⁴⁴ more...

MalaCards: Diabetic Ketoacidosis, also known as diabetes mellitus, ketosis-prone, is related to gestational diabetes and retinol binding protein. An important gene associated with Diabetic Ketoacidosis is INS (insulin), and among its related pathways are GABA synthesis and Cell adhesion molecules (CAMs). The drugs chromium picolinate and insulin,nph,pork/purified and the compounds glucose and citrate have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and pituitary, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

OMIM: 612227

Aliases & Descriptions:

diabetic ketoacidosis 6 32 43 diabetes mellitus, ketosis-prone 6 33 diabetes mellitus, insulin-dependent 43

ketosis-prone diabetes mellitus 6 diabetes mellitus 43

Diseases related to diabetic ketoacidosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 874)

id	Related Disease	Score	Top Affiliating Genes
1	gestational diabetes	38.7	INS, HNF4A, LSL, ADRB3, GAD1
2	retinol binding protein	33.6	INS, ALB, HNF4A, CRP
3	autonomic neuropathy	33.6	INS, ALB, AGER, GAD1, GAD2
4	diabetic neuropathy	33.5	INS, AGER, GAD1, GAD2
5	celiac disease	32.7	IL6, HLA-DQB1, HLA-DRB1, CTLA4
6	glucose intolerance	32.3	INS, HNF4A, CRP, LSL, ADRB3, GAD1
7	proteinuria	32.1	PIK3C2A, VWF, INS, ICAM1, ALB, CRP
8	periodontitis	32.1	IL10, IL6, ELANE, AGER
9	autoimmune thyroiditis	32.0	CHKB, ICAM1, CALCA, TPO, CTLA4, TG
10	ischemic heart disease	31.7	PIK3C2A, CHKB, TNNI3, CRP, LSL
11	diabetes, type 2	31.7	INS, IL18, ALB
12	vascular disease	31.6	VWF, INS, F5, ICAM1, CRP, ELANE
13	hypoglycemia	31.5	BTD, CHKB, INS, IL6, F5, ALB
14	morbid obesity	31.2	INS, LSL, ADRB3, GAD2
15	homocysteine	31.0	PIK3C2A, VWF, BTD, INS, IL18, IL6
16	hypothyroidism	30.9	CALCA, TPO, TG
17	hyperlipidemia	30.8	PIK3C2A, VWF, CHKB, INS, IL6, ALB
18	hyperinsulinism	30.8	INS, HNF4A, SST, LSL
19	hypertriglyceridemia	30.7	INS, IL18, IL6, ICAM1, ALB, SST
20	obesity, association with	30.5	VWF, INS, IL6, ALB, CRP, ADRB3
21	hyperandrogenism	30.4	INS, IL6, CRP, LSL, ADRB3
22	fatty liver disease	30.3	INS, IL6, ALB, HNF4A, CRP, LSL
23	pulmonary tuberculosis	30.3	IL10, IL18, HLA-DQB1, HLA-DRB1
24	insulinoma	29.9	CHKB, INS, CALCA, HNF4A, SST, LSL
25	lipodystrophy	29.8	INS, IL18, IL6, HLA-DQB1, HLA-DRB1, SST
26	acromegaly	29.7	BGLAP, INS, IL6, ALB, CALCA, SST
27	nephropathy	29.7	VWF, INS, IL10, IL18, IL6, AQP2
28	glomerulopathy	29.6	VWF, INS, F5, ICAM1, ALB
29	hemochromatosis	29.6	INS, IL6, F5, ALB, CALCA, HLA-DRB1
30	hypoparathyroidism	29.6	PIK3C2A, BGLAP, INS, CALCA, TPO, CTLA4
31	periodontal disease	29.5	BGLAP, IL18, IL6, CTLA4, CRP, ELANE
32	multiple sclerosis	29.5	HLA-DQB1, HLA-DRB1
33	glucagonoma	29.5	INS, CALCA, SST
34	maturity-onset diabetes of the young	29.3	INS, HNF4A, HLA-DQB1, GAD1
35	polycystic kidney disease	29.3	PIK3C2A, INS, AQP2, ALB, SST
36	liver cirrhosis	29.2	AQP2, ALB, HNF4A, HLA-DRB1, SST, LSL
37	diabetic retinopathy	29.2	VWF, CLDN5, BGLAP, INS, IL10, IL6
38	stiff-person syndrome	29.2	INS, GAD1, GAD2
39	diabetic foot ulcers	29.2	CALCA, CRP, CSF3
40	short stature	29.0	BGLAP, INS, ALB, CALCA, SST
41	werner syndrome	29.0	BGLAP, INS, IL6, ICAM1
42	hypogonadism	29.0	BGLAP, INS, IL6, F5, ALB, CALCA
43	insulin autoimmune syndrome	29.0	INS, F5
44	familial combined hyperlipidemia	28.9	INS, LSL, ADRB3
45	cataract	28.8	INS, IL6, ALB, CALCA, CRP, G6PD
46	congestive heart failure	28.7	PIK3C2A, CHKB, AQP2, ADRB3
47	megaloblastic anemia	28.7	TPO, TG
48	hyperinsulinemic hypoglycemia	28.6	INS, HNF4A, SST
49	diabetic angiopathy	28.6	VWF, INS, AGER
50	hypertension	28.5	PIK3C2A, VWF, BGLAP, INS, IL10, IL18

Clinical features from OMIM: 612227

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chromium picolinate, insulin, insulin,aspart protamine, insulin,aspart,human/rdna, insulin,detemir,human, insulin,glargine,human/rdna, insulin,glulisine,human, insulin,lente,beef, insulin,lente,beef/pork, insulin,lente,beef/purified, insulin,lente,human/rdna, insulin,lente,human/semisynthetic, insulin,lente,pork/purified, insulin,lispro,human/rdna, insulin,lispro,protamine/rdna, insulin,nph,beef, insulin,nph,beef/pork, insulin,nph,beef/purified, insulin,nph,human/rdna, insulin,nph,human/semisynthetic, insulin,nph,pork/purified, insulin,protamine zinc,beef/pork, insulin,protamine zinc,beef/purified, insulin,protamine zinc,pork/purified, insulin,regular,beef/pork, insulin,regular,beef/purified, insulin,regular,human buffered, insulin,regular,human/rdna, insulin,regular,human/semisynthetic, insulin,regular,pork, insulin,regular,pork/purified, insulin,semilente,beef, insulin,semilente,beef/pork, insulin,semilente,pork/purified, insulin,ultralente,beef, insulin,ultralente,beef/pork, insulin,ultralente,beef/purified, insulin,ultralente,human, insulin,ultralente,human/rdna, pramlintide

MalaCards organs/tissues related to diabetic ketoacidosis:

²²

MGI Mouse Phenotypes related to diabetic ketoacidosis:

²⁵ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.1	BTD, INS, AQP2
2	endocrine/exocrine gland phenotype	MP:0005379	10.0	CTLA4, ADRB3, GAD2
3	digestive/alimentary phenotype	MP:0005381	9.4	GAD2, GAD1, CTLA4, SST, IL18, INS
4	hematopoietic system phenotype	MP:0005397	9.4	CSF3, TG, HLA-DQB1
5	integument phenotype	MP:0010771	9.0	CSF3, CTLA4, CALCA, F5, BTD
6	immune system phenotype	MP:0005387	8.6	GAD2, AGER, ELANE, HLA-DQB1, IL6, VWF
7	nervous system phenotype	MP:0003631	8.3	GAD2, GAD1, TG, G6PD, HLA-DQB1, HNF4A
8	normal phenotype	MP:0002873	7.8	CTLA4, ELANE, AGER, GAD1, SST, HLA-DQB1
9	growth/size phenotype	MP:0005378	7.5	SST, AGER, TG, ADRB3, GAD1, GAD2
10	muscle phenotype	MP:0005369	7.1	HLA-DQB1, TNNI3, AGER, GAD2, ICAM1, IL6
11	mortality/aging	MP:0010768	7.0	TNNI3, CTLA4, ELANE, G6PD, GAD1, GAD2
12	behavior/neurological phenotype	MP:0005386	6.6	HLA-DQB1, TNNI3, SST, AGER, ADRB3, GAD1
13	cardiovascular system phenotype	MP:0005385	6.0	CALCA, HLA-DQB1, TNNI3, CTLA4, CRP, G6PD
14	homeostasis/metabolism phenotype	MP:0005376	3.7	PIK3C2A, HLA-DQB1, TPO, SST, CTLA4, CRP

Articles related to diabetic ketoacidosis:

(show top 50)    (show all 98)

id	Title	Authors	Year	Affiliating Genes
1	Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effe cts of bumetanide. (20028943)	Glaser N.... O'Donnell M.E.	2010	INS
2	Relapse of diabetic ketoacidosis secondary to insulin pump malfunction diagnosed by capillary blood 3-hydroxybutyrate: a case report . (19918445)	Baird J.S.	2009	INS
3	Haemolysis during diabetic ketoacidosis treatment in two girls with incomplete glucose-6-phosphate dehydrogenase deficiency. (19705624)	Errico M.K.... Vanelli M.	2009	G6PD
4	Insulin analogs versus human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial. (19366972)	Umpierrez G.E.... Robalino G.	2009	INS
5	Diabetic ketoacidosis caused by exposure of insulin pump to heat and sunlight. (19124546)	Pryce R.	2009	INS
6	Is subcutaneous administration of rapid-acting insulin as effective as intravenous insulin for treating diabetic ketoacidosis? (19177639)	Mazer M.... Chen E.	2009	INS
7	Receptor for advanced glycation end products and neuronal deficit in the fatal brain edema of diabetic ketoacidosis. (18775683)	Hoffman W.H.... Sima A.A.	2008	AGER
8	Glucocorticoid-induced diabetic ketoacidosis in acute rheumatic fever. (19087951)	CaA9daA9 D.N.... Cakal E.	2008	INS
9	Cardiac troponin I concentrations in people presenting with diabetic ketoacidosis. (17594788)	Geddes J.... Fisher B.M.	2007	TNNI3, CHKB
10	Serum interleukin-18 levels are raised in diabetic ketoacidosis in Chinese children with type 1 diabetes mellitus. (17998573)	Dong G.... Zou C.	2007	IL18
11	Olanzapine-induced diabetic ketoacidosis in a Chinese man. (17277396)	Wong J.O.... Hung G.B.	2007	INS
12	Insulin glargine supplementation during early management phase of diabetic ketoacidosis in children. (17508198)	Shankar V.... Russell W.	2007	INS
13	Diabetic ketoacidosis in a patient with acromegaly. (17908670)	Chen Y.L.... Chang T.C.	2007	INS
14	Diabetic ketoacidosis revealing glucose-6-phosphate dehydrogenase deficiency: description of an adult case. (17296519)	Le Pommelet C.... Zunic P.	2006	G6PD
15	Diabetic ketoacidosis--a possible complicating factor in deaths associated with drug overdose: two case reports. (16454466)	Byard R.W.... Felgate H.E.	2006	INS
16	Insulin and glucagon ratio in the patho-physiology of diabetic ketoacidosis and hyperosmolar hyperglycemic non-ketotic diabetes. (16441980)	Wahid M.... Hussain I.	2006	INS
17	Diabetic ketoacidosis and hyperosmolar hyperglycemic state. (16802531)	Gouni-Berthold I.... Krone W.	2006	INS
18	Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion. (16105971)	Kim D.M.... Lee E.J.	2005	SST
19	Diabetic ketoacidosis: risk factors, mechanisms and m anagement strategies in sub-Saharan Africa: a review. (16619733)	Otieno C.F.... Oyoo G.O.	2005	INS
20	Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein. (16009359)	Oglesbee M.J.... Hoffman W.H.	2005	HSPA1A
21	Bone calcium changes during diabetic ketoacidosis: a comparison with lactic acidosis due to volume depletion. (15869925)	Topaloglu A.K.... Ozer G.	2005	CALCA, INS, BGLAP
22	Subcutaneous use of a fast-acting insulin analog: an alternative treatment for pediatric patients with diabetic ketoacidosis. (16043723)	Della Manna T.... Damiani D.	2005	INS
23	Managing diabetic ketoacidosis: the role of the ICU nurse in an endocrine emergency. (15460517)	Hurlock-Chorostecki C.	2004	INS
24	Fatal cerebral infarctions in diabetic ketoacidosis i n a child with previously unknown heterozygosity for factor V Leiden deficiency . (15480386)	Rosenbloom A.L.	2004	F5
25	Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. (15336577)	Umpierrez G.E.... E Kitabchi A.	2004	INS
26	A novel approach to preventing diabetic ketoacidosis in a patient treated with an insulin pump. (14514614)	Phillips B.D.... Levy J.R.	2003	INS
27	A case showing complete insulin independence after severe diabetic ketoacidosis associated with tacrolimus treatment. (12196452)	Cho Y.M.... Lee H.K.	2002	INS
28	Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis. (12021537)	Kusaka I.... Ishikawa S.E.	2002	AQP2
29	Diabetic ketoacidosis in children: review of pathophysiology and treatment with the use of the 'two bags system' (14647613)	Collett-Solberg P.F.	2001	INS
30	Diabetic ketoacidosis in a case of pheochromocytoma. (11640997)	Ishii C.... Katayama S.	2001	ADRB3
31	Diabetic ketoacidosis in a patient with acromegaly. (11208511)	Kopff B.... Drzewoski J.	2001	INS
32	Clinical experience with insulin resistance, diabetic ketoacidosis, and type 2 diabetes mellitus in patients treated with atypical a ntipsychotic agents. (11806484)	Henderson D.C.	2001	INS
33	Factors associated with discontinuing insulin therapy after diabetic ketoacidosis in adult diabetic patients. (11703434)	Hsin Yu E.... Wu T.J.	2001	INS
34	Post-transplant diabetic ketoacidosis--a possible consequence of immunosuppression with calcineurin inhibiting agents: a case series. (10743693)	Yoshida E.M.... Landsberg D.N.	2000	INS
35	Pituitary gigantism causing diabetic ketoacidosis. (10614552)	Alvi N.S.... Kirk J.M.	1999	INS
36	Effects of long-acting somatostatin analogue (Sandostatin) on manifest diabetic ketoacidosis. (10765004)	Yun Y.S.... Huh K.B.	1999	SST, INS
37	Serum levels of leptin and changes during the course of recovery from diabetic ketoacidosis. (10580617)	Nakamura T.... Saito T.	1999	INS, LSL
38	Practical management of diabetic ketoacidosis in childhood and adolescence. (9822196)	Silink M.	1998	INS
39	Diabetic ketoacidosis among obese African-American adolescents with NIDDM. (9096965)	Pinhas-Hamiel O.... Zeitler P.S.	1997	INS
40	Acromegaly in a woman presenting with diabetic ketoacidosis and insulin resistance. (9536592)	Szeto C.C.... Cockram C.S.	1997	INS
41	Diabetic ketoacidosis--personal experience with treatment using low (physiologic) doses of insulin (8928408)	BaranikovA! D.... VavrA-k J.	1996	INS
42	Diabetic ketoacidosis and hyperosmolar nonketotic state: gaining control over extreme hyperglycemic complications. (8668627)	Gonzalez-Campoy J.M.... Robertson R.P.	1996	INS
43	Insulin therapy for diabetic ketoacidosis. Bolus insulin injection versus continuous insulin infusion. (7587857)	Butkiewicz E.K.... Rizza R.A.	1995	INS
44	GAD antibody negative NIDDM in adult black subjects with diabetic ketoacidosis and increased frequency of human leukocyte antigen DR3 and DR4. Flatbush diabetes. (8194658)	Banerji M.A.... Lebovitz H.E.	1994	GAD1, INS
45	Diabetic ketoacidosis in prisoners without access to insulin. (8421367)	Keller A.S.... Schwartz M.D.	1993	INS
46	Diabetic ketoacidosis--a study of 33 episodes. (8153679)	Rajasoorya C.... Chew L.S.	1993	INS
47	Leukemoid reaction associated with diabetic ketoacidosis--with measurement of plasma levels of granulocyte colony-stimulating factor. (7516746)	Kayashima T.... Hosokawa T.	1993	CSF3
48	Intractable diabetic ketoacidosis due to insulin antibody--response to steroid therapy. (2168254)	Chang T.C.... Ho L.T.	1990	INS
49	Diabetic ketoacidosis and pregnancy. (2165729)	Bertolino J.G.	1990	INS
50	Diabetic ketoacidosis at the Children's Hospital of O klahoma: a review on presentation and management. (2127058)	Blackett P.R.... Parker M.	1990	INS

Genes related to diabetic ketoacidosis according to GeneCards:

(show all 35)

id	Symbol	Description	Score	GeneCards Section Context
1	INS	insulin	11.0	Publications
2	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
3	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11.0
4	LSL	Leptin, serum levels of	11.0	Publications
5	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0
6	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0
7	AMY2A	amylase, alpha 2A (pancreatic)	11.0	Publications
8	CLDN5	claudin 5	11.0	Publications
9	TNNI3	troponin I type 3 (cardiac)	11.0	Publications
10	ADRB3	adrenoceptor beta 3	11.0	Publications
11	AQP2	aquaporin 2 (collecting duct)	11.0	Publications
12	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
13	BTD	biotinidase	11.0	Publications
14	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
15	HSPA1A	heat shock 70kDa protein 1A	11.0	Publications
16	CHKB	choline kinase beta	11.0	Publications
17	HLCS	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	11.0	Publications
18	TPO	thyroid peroxidase	11.0	Publications
19	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
20	SST	somatostatin	11.0	Publications
21	HNF4A	hepatocyte nuclear factor 4, alpha	11.0	Publications
22	ELANE	elastase, neutrophil expressed	11.0	Publications
23	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
24	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
25	TG	thyroglobulin	11.0	Publications
26	VWF	von Willebrand factor	11.0	Publications
27	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
28	ICAM1	intercellular adhesion molecule 1	11.0	Publications
29	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
30	ALB	albumin	11.0	Publications
31	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
32	CRP	C-reactive protein, pentraxin-related	11.0	Publications
33	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
34	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
35	IL10	interleukin 10	11.0	Publications

Pathways related to diabetic ketoacidosis according to GeneDecks:

(show all 21)

id	Pathway	Score	Top Affiliating Genes
1	GABA synthesis38	10.5	GAD2, GAD1
2	Cell adhesion molecules (CAMs)20	10.5	CTLA4, CLDN5
3	Biotin metabolism20	10.3	HLCS, BTD
4	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	10.1	PIK3C2A, INS, HNF4A
5	Glucose / Energy Metabolism3	10.0	AQP2, HNF4A, G6PD, GAD2
6	Type I diabetes mellitus20	9.6	GAD2, GAD1, HLA-DRB1, HLA-DQB1, INS
7	CD28 Signaling in T-Helper Cell36	9.4	PIK3C2A, HLA-DQB1, HLA-DRB1, CTLA4
8	THC Differentiation Pathway36	9.2	HLA-DRB1, HLA-DQB1, IL18, IL10
9	Asthma20	9.2	HLA-DRB1, HLA-DQB1, IL10
10	Allograft rejection20	9.1	IL10, HLA-DQB1, HLA-DRB1
11	Staphylococcus aureus infection20	9.0	IL10, ICAM1, HLA-DQB1, HLA-DRB1
12	African trypanosomiasis20	8.9	IL10, IL18, IL6, ICAM1
13	Autoimmune thyroid disease20	8.8	IL10, HLA-DQB1, HLA-DRB1, TPO, CTLA4, TG
14	Cytokine Network36	8.8	IL6, IL18, IL10
15	Metabolic pathways20	8.8	HLCS, GAD2, GAD1, G6PD, TPO, AMY2A
16	Intestinal immune network for IgA production20	8.6	HLA-DRB1, HLA-DQB1, IL6, IL10
17	Hematopoietic cell lineage20	8.5	CSF3, TPO, HLA-DRB1, IL6
18	Rheumatoid arthritis20	8.5	CTLA4, HLA-DRB1, HLA-DQB1, ICAM1, IL6, IL18
19	Influenza A20	8.4	HLA-DRB1, HLA-DQB1, HSPA1A, ICAM1, IL6, IL18
20	Malaria20	8.3	CSF3, ICAM1, IL6, IL18, IL10
21	Tuberculosis20	8.3	HLA-DRB1, HLA-DQB1, IL6, IL18, IL10

Compounds related to diabetic ketoacidosis according to GeneDecks:

(show top 50)    (show all 231)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.5	BTD, HSPA1A
2	citrate32	10.3	CHKB, HSPA1A, PIK3C2A
3	c-peptide32	10.0	GAD2, GAD1, ADRB3, LSL, TPO, HNF4A
4	nitroglycerin32 9 9	11.9	SST, ELANE
5	ascorbic acid32 18	10.8	G6PD, CHKB, TG, BGLAP, TPO
6	methimazole32 9 9	11.7	G6PD, LSL, ICAM1, BGLAP, VWF
7	glutamate32	9.7	GAD1, INS, CALCA, HNF4A, SST, CTLA4
8	ivig32	9.5	PIK3C2A, TG, VWF, CRP
9	urea32 9 18 9	12.3	F5, ALB, LSL, ADRB3, PIK3C2A, CHKB
10	fluvastatin32 34 9 9	12.3	PIK3C2A, IL6, CHKB, VWF
11	aspartate32	9.2	PIK3C2A, CHKB, TG, TPO, HLA-DQB1, F5
12	malondialdehyde32	9.1	PIK3C2A, CHKB, F5, CRP, AGER, G6PD
13	epinephrine32 9 18 9	12.0	PIK3C2A, INS, ADRB3, TG, ELANE, LSL
14	cysteine32	8.7	BTD, BGLAP, CHKB, GAD2, AQP2, ALB
15	pravastatin32 34 9 18 9	12.6	LSL, PIK3C2A, CHKB, CRP, IL6, IL18
16	endotoxin32	8.6	F5, CHKB, CSF3, IL18, HSPA1A, CRP
17	uric acid32 18	9.4	ADRB3, AGER, G6PD, LSL, CRP, TPO
18	mycophenolate mofetil32 9 9	10.4	CSF3, CTLA4, ALB, F5, IL10, IL18
19	clozapine32 34 9 9	11.2	CHKB, IL10, CRP, LSL, CSF3, ADRB3
20	infliximab32 9 9	10.2	LSL, IL10, IL18, IL6, BGLAP, CTLA4
21	gabexate mesilate32	8.2	F5, IL6, CRP, ELANE, SST, IL10
22	acetylcholine32 9 18 9	11.1	TPO, TG, ELANE, CRP, GAD1, CTLA4
23	testosterone32 9 18 9	11.0	F5, CALCA, HNF4A, SST, LSL, ELANE
24	8-isoprostane32	8.0	IL10, CRP, ICAM1, IL6, HSPA1A, INS
25	creatinine32	8.0	TG, AGER, G6PD, LSL, CRP, TNNI3
26	gm-csf32	7.9	ICAM1, ELANE, IL6, IL18, IL10, CSF3
27	neopterin32	7.8	IL10, CHKB, CRP, ICAM1, IL6, IL18
28	pamidronate32 9 9	9.8	CRP, CALCA, IL6, IL10, BGLAP
29	calcium32 9 18 9	10.8	GAD2, GAD1, AGER, TNNI3, TPO, HSPA1A
30	glutamine32	7.6	VWF, CHKB, IL18, F5, HSPA1A, HNF4A
31	vitamin d32	7.5	IL6, BGLAP, HNF4A, ALB, CTLA4, ELANE
32	thyroxine32 18	8.5	TG, G6PD, ELANE, LSL, SST, TPO
33	atorvastatin32 34 9 18 9	11.5	CRP, IL6, F5, IL18, ICAM1, IL10
34	arginine32	7.4	GAD1, ADRB3, LSL, SST, TPO, HLA-DRB1
35	hydrocortisone32 9 9	9.4	INS, BGLAP, IL10, IL6, AQP2, TG
36	simvastatin32 34 42 9 18 9	12.2	CHKB, PIK3C2A, CRP, ICAM1, BGLAP, VWF
37	norepinephrine32 9 18 9	10.2	ADRB3, TG, ELANE, LSL, CRP, SST
38	fibrinogen32	7.0	F5, LSL, ELANE, CRP, TPO, VWF
39	estrogen32	6.8	CHKB, INS, VWF, CTLA4, BGLAP, ADRB3
40	lipid32	6.8	CTLA4, TPO, HNF4A, INS, CRP, LSL
41	methotrexate32 34 42 9 9	10.7	IL10, CHKB, PIK3C2A, IL18, ALB, CSF3
42	cholesterol32 9 18 9	9.6	CRP, GAD2, GAD1, LSL, AGER, ADRB3
43	nitric oxide32 9 18 9	9.5	HSPA1A, HNF4A, TPO, LSL, AGER, ICAM1
44	prednisolone32 9 9	8.4	VWF, IL6, IL18, IL10, CHKB, BGLAP
45	dexamethasone32 42 34 9 9	10.3	CSF3, CTLA4, ADRB3, IL10, LSL, SST
46	cyclosporin a32 42	7.0	PIK3C2A, VWF, BGLAP, GAD2, GAD1, CSF3
47	alanine32	5.7	GAD2, TG, LSL, CRP, CTLA4, HLA-DRB1
48	tyrosine32	5.6	AGER, CTLA4, GAD2, CSF3, TPO, HLCS
49	vegf32	5.6	IL6, VWF, PIK3C2A, CHKB, CALCA, IL10
50	lactate32	5.6	HLCS, TG, G6PD, ELANE, LSL, CRP

Cellular components related to diabetic ketoacidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	transport vesicle membrane	GO:030658	9.5	AQP2, HLA-DQB1, HLA-DRB1
2	extracellular region	GO:005576	5.9	CALCA, SST, CRP, ELANE, AGER, TG
3	extracellular space	GO:005615	5.4	BTD, CSF3, CRP, SST, CALCA, ALB

Biological processes related to diabetic ketoacidosis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate decarboxylation to succinate	GO:006540	10.4	GAD1, GAD2
2	type 2 immune response	GO:042092	9.6	IL10, IL18
3	negative regulation of chemokine biosynthetic process	GO:045079	9.5	IL6, ELANE
4	cell-cell signaling	GO:007267	9.1	INS, IL10, IL18, CALCA, SST
5	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	INS, IL6, ICAM1, AGER
6	response to drug	GO:042493	8.9	BGLAP, GAD2, GAD1, SST, HNF4A, ICAM1
7	acute-phase response	GO:006953	8.7	CRP, IL6, INS
8	inflammatory response	GO:006954	8.1	AGER, CRP, CALCA, IL6, IL18, IL10
9	cytokine-mediated signaling pathway	GO:019221	7.9	CSF3, HLA-DRB1, HLA-DQB1, ICAM1, IL6

Molecular functions related to diabetic ketoacidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate decarboxylase activity	GO:004351	10.2	GAD1, GAD2
2	hormone activity	GO:005179	9.3	INS, CALCA, SST, TG