MCID: DBT001
MIFTS: 65

Diabetic Ketoacidosis malady

Summaries for Diabetic Ketoacidosis

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes... more...

MalaCards: Diabetic Ketoacidosis, also known as diabetes mellitus, ketosis-prone, is related to diabetes mellitus and type 1 diabetes mellitus. An important gene associated with Diabetic Ketoacidosis is PAX4 (paired box 4), and among its related pathways are Regulation of beta-cell development and Alanine, aspartate and glutamate metabolism. The drugs insulin and insulin, aspart, human and the compounds repaglinide and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are behavior/neurological and digestive/alimentary.

Description from OMIM:48 612227

Aliases & Classifications for Diabetic Ketoacidosis

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9Disease Ontology, 46Novoseek, 63UMLS, 10diseasecard, 48OMIM, 23GTR, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH
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Aliases & Descriptions:

diabetic ketoacidosis 9 46 63
diabetes mellitus, ketosis-prone 9 10 48
ketosis-prone diabetes mellitus 9 23
diabetes mellitus, insulin-dependent 63


External Ids:

Disease Ontology9 DOID:1837
NCIt41 C50530
ICD9CM28 250.1
MeSH36 D016883
OMIM48 612227

Related Diseases for Diabetic Ketoacidosis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Diabetic Ketoacidosis:



Diseases related to diabetic ketoacidosis

Symptoms for Diabetic Ketoacidosis

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48OMIM
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Symptoms by clinical synopsis from OMIM:

612227

Clinical features from OMIM:

612227

Genetic Tests for Diabetic Ketoacidosis

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23GTR
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Genetic tests related to Diabetic Ketoacidosis:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Ketosis-Prone23

Anatomical Context for Diabetic Ketoacidosis

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34MalaCards
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MalaCards organs/tissues related to Diabetic Ketoacidosis:

34
Brain, Testes, Pituitary, Heart, Thyroid, Bone, Spinal cord, Endothelial, Small intestine, Pancreatic islet, Liver

Animal Models for Diabetic Ketoacidosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetic Ketoacidosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.2GAD2, GAD1, AQP2, INS
2MP:00053818.1INS, GAD1, GAD2, CTLA4
3MP:00053797.8CTLA4, GAD2, GAD1, PAX4, INS
4MP:00028737.8INS, PAX4, GAD1, GAD2, CTLA4
5MP:00053787.6GAD2, GAD1, PAX4, AQP2, INS
6MP:00053767.2INS, AQP2, GAD1, GAD2, CTLA4
7MP:00107687.2INS, AQP2, PAX4, GAD1, GAD2, CTLA4

Publications for Diabetic Ketoacidosis

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53PubMed
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Articles related to Diabetic Ketoacidosis:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Effect of normal saline and half normal saline on serum electrolytes during recovery phase of diabetic ketoacidosis. (23753222)
2014
2
Microdialysis monitoring of glucose, lactate, glycerol, and pyruvate in patients with diabetic ketoacidosis. (24362895)
2013
3
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent. (23729615)
2013
4
Possibility to reduce mortality in diabetic ketoacidosis. (23931740)
2013
5
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
6
Increasing use of hypertonic saline over mannitol in the treatment of symptomatic cerebral edema in pediatric diabetic ketoacidosis: an 11-year retrospective analysis of mortality*. (23863818)
2013
7
Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. (23075084)
2013
8
Spontaneous Pneumomediastinum in a Patient With Diabetic Ketoacidosis. (24139747)
2013
9
The role of the Armanni-Ebstein lesion, hepatic steatosis, biochemical analysis and second generation anti-psychotic drugs in fatal diabetic ketoacidosis. (23357396)
2013
10
Hypertension in severe pediatric diabetic ketoacidosis: case report and review of literature. (23283273)
2013
11
Deep vein thrombosis and pulmonary embolism in a child with diabetic ketoacidosis and protein s deficiency: a case report. (23306559)
2013
12
Intravenous sodium bicarbonate therapy in severely acidotic diabetic ketoacidosis. (23737516)
2013
13
Intracranial pressure/cerebral perfusion pressure-targeted management of life-threatening intracranial hypertension complicating diabetic ketoacidosis-associated cerebral edema: a case report. (22766587)
2012
14
The role of point-of-care I^-hydroxybutyrate testing in the diagnosis of diabetic ketoacidosis: a review. (22615081)
2012
15
Polyglandular autoimmune syndrome (PGA)--type 2 with diabetic ketoacidosis. (22009276)
2012
16
Bilateral posterior ischemic optic neuropathy in a patient with severe diabetic ketoacidosis. (21475607)
2011
17
Management of diabetic ketoacidosis. (21526698)
2011
18
Diagnostic approach to drug-screening tests for fatal diabetic ketoacidosis: forensic autopsy of a methamphetamine abuser. (20444635)
2010
19
Utility of initial bolus insulin in the treatment of diabetic ketoacidosis. (18514472)
2010
20
Passing the acid test. What you need to know about diabetic ketoacidosis. (20405612)
2010
21
Fatal massive cerebral infarctions in a young patient with diabetic ketoacidosis--a rare case of atherosclerotic moyamoya disease. (19917648)
2010
22
The performance of a glucose-ketone meter in the diagnosis of diabetic ketoacidosis in patients with type 2 diabetes in the emergency room. (20597827)
2010
23
Neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report. (21274328)
2010
24
Two cases of type 1 diabetic women with diabetic ketoacidosis presenting as alkalaemia. (19117632)
2009
25
Heparin treatment for severe hypertriglyceridemia in diabetic ketoacidosis. (19667310)
2009
26
Hypophosphatemia-induced seizure in a child with diabetic ketoacidosis. (20016359)
2009
27
Diabetic ketoacidosis in children and adolescents with diabetes. (19754623)
2009
28
New-onset diabetes mellitus presenting with diabetic ketoacidosis after pediatric liver transplantation. (19207220)
2009
29
Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia. (19687585)
2009
30
Diabetic ketoacidosis, respiratory distress and myocardial dysfunction. (22132021)
2009
31
Incidence of Diabetic Ketoacidosis during Ramadan Fasting in Benghazi-Libya. (22334853)
2009
32
Evaluating the safety and efficacy of Glucommander, a computer-based insulin infusion method, in management of diabetic ketoacidosis in children, and comparing its clinical performance with manually titrated insulin infusion. (19449669)
2009
33
Young children (<5 yr) and adolescents (>12 yr) with type 1 diabetes mellitus have low rate of partial remission: diabetic ketoacidosis is an important risk factor. (18547233)
2008
34
Diabetic ketoacidosis: the usual villain or a scapegoat? A novel cause of severe metabolic acidosis in type 1 diabetes. (18308676)
2008
35
Management of diabetic ketoacidosis in children and adolescents. (19047433)
2008
36
A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. (18651203)
2008
37
Insulin in special situations: diabetic ketoacidosis. (17927011)
2007
38
Euglycemic diabetic ketoacidosis in pregnancy. (17951948)
2007
39
Diabetic ketoacidosis: principles of management. (17953311)
2007
40
Spontaneous pneumorrhachis associated with pneumomediastinum in a patient with diabetic ketoacidosis: an exceptional manifestation of a benign disease. (17568499)
2007
41
Severe hypernatremia and hyperosmolality exacerbated by an herbal preparation in a patient with diabetic ketoacidosis. (17585008)
2007
42
Efficacy of subcutaneous insulin lispro versus continuous intravenous regular insulin for the treatment of patients with diabetic ketoacidosis. (15336577)
2004
43
Diagnosis and treatment of diabetic ketoacidosis and the hyperglycemic hyperosmolar state. (12668546)
2003
44
Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis. (14976569)
2003
45
Association between diabetic ketoacidosis and thyrotoxicosis. (12486499)
2002
46
Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. (9283776)
1997
47
Recent advances in management of diabetic ketoacidosis. (10771810)
1997
48
Insulin-dependent diabetes mellitus presenting as diabetic ketoacidosis in pregnancy. (8546655)
1995
49
Diabetic ketoacidosis in pregnancy resulting from insulin pump failure. A case report. (8501740)
1993
50
Malignant somatostatinoma presenting with diabetic ketoacidosis. (2822297)
1987

Variations for Diabetic Ketoacidosis

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Expression for genes affiliated with Diabetic Ketoacidosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Ketoacidosis

Search GEO for disease gene expression data for Diabetic Ketoacidosis.

Pathways for genes affiliated with Diabetic Ketoacidosis

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Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 13EMD Millipore, 55R&D Systems, 61Thomson Reuters, 5Cell Signaling Technology, 54QIAGEN
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Pathways related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6INS, PAX4
29.1GAD2, GAD1
3
Show member pathways
9.1GAD2, GAD1
4
Show member pathways
9.1GAD2, GAD1
5
Show member pathways
9.1GAD2, GAD1
6
Show member pathways
phenylethylamine degradation I39
9.1GAD2, GAD1
7
Show member pathways
9.1GAD2, GAD1
8
Show member pathways
9.1GAD2, GAD1
9
Show member pathways
9.1GAD2, GAD1
10
Show member pathways
catecholamine biosynthesis39
9.1GAD1, GAD2
119.1GAD1, GAD2
128.7GAD2, AQP2, INS
13
Show member pathways
8.1CTLA4, GAD2, GAD1, INS

Compounds for genes affiliated with Diabetic Ketoacidosis

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Sources:
52PharmGKB, 46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1repaglinide52 46 1212.0PAX4, INS
2streptozotocin469.9GAD1, INS
32-deoxyglucose46 1210.8INS, GAD1
4furosemide46 62 30 52 25 1214.8AQP2, GAD1
5haloperidol46 52 30 3 1213.7GAD1, AQP2
6Cysteic acid259.6GAD2, GAD1
7cysteine sulfinic acid469.6GAD1, GAD2
8hypotaurine62 46 2511.6GAD2, GAD1
93-Sulfinoalanine25 1210.6GAD2, GAD1
10pyridoxal46 25 1211.5GAD2, GAD1
11L-Aspartic acid25 1210.5GAD2, GAD1
12beta-alanine46 62 30 25 1213.5GAD2, GAD1
13Gamma-Aminobutyric acid259.5GAD1, GAD2
14taurine46 62 2511.5GAD2, GAD1
15pyridoxal 5-phosphate469.5GAD2, GAD1
16famotidine46 3 25 1212.5GAD2, GAD1
17mptp469.5GAD1, GAD2
18Pyridoxal 5'-phosphate259.5GAD2, GAD1
19tetrodotoxin46 62 3011.4GAD2, GAD1
20l-glutamic acid30 25 1211.4GAD1, GAD2
21levodopa46 1210.4GAD2, GAD1
22hydrocortisone46 3 62 1212.4AQP2, INS
23carbon dioxide46 2510.4GAD1, GAD2
24kainate46 3010.3GAD1, GAD2
25creatinine469.3GAD1, AQP2, INS
26ornithine46 2510.3GAD2, GAD1
27methionine469.2AQP2, GAD1, CTLA4
28arginine469.1GAD1, AQP2, INS
29dexamethasone46 52 30 1212.1CTLA4, AQP2, INS
30c-peptide469.1GAD2, GAD1, INS
31steroid469.1CTLA4, GAD1, AQP2
32hydrogen46 2510.0GAD2, GAD1, AQP2
33acetylcholine46 52 30 25 1212.9CTLA4, GAD2, GAD1
34choline46 25 1210.8GAD2, GAD1
35nitric oxide46 25 1210.7AQP2, GAD1, GAD2
36atp46 309.6GAD2, GAD1, AQP2
37threonine468.6CTLA4, GAD2, AQP2
38cholesterol46 30 25 1211.5INS, GAD1, GAD2, CTLA4
39glutamate468.5INS, GAD1, GAD2, CTLA4
40cyclosporin a46 30 6210.4AQP2, GAD1, GAD2, CTLA4
41cysteine468.4AQP2, GAD1, GAD2, CTLA4
42tyrosine468.4CTLA4, GAD2, GAD1, INS
43calcium46 52 25 1211.0AQP2, GAD1, GAD2, CTLA4
44alanine468.0INS, AQP2, GAD1, GAD2, CTLA4
45glucose467.6CTLA4, GAD2, GAD1, PAX4, AQP2, INS

GO Terms for genes affiliated with Diabetic Ketoacidosis

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17Gene Ontology
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Cellular components related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.1GAD2, GAD1

Biological processes related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell differentiationGO:0455979.5INS, PAX4
2endocrine pancreas developmentGO:0310189.3PAX4, INS
3glutamate decarboxylation to succinateGO:0065409.2GAD2, GAD1
4neurotransmitter biosynthetic processGO:0421369.2GAD2, GAD1
5neurotransmitter secretionGO:0072699.1GAD2, GAD1
6response to drugGO:0424938.7PAX4, GAD1, GAD2

Molecular functions related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:0301709.1GAD2, GAD1
2glutamate decarboxylase activityGO:0043519.0GAD2, GAD1
3glutamate bindingGO:0165958.8GAD2, GAD1

Products for genes affiliated with Diabetic Ketoacidosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetic Ketoacidosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet