MCID: DBT001
MIFTS: 69

Diabetic Ketoacidosis malady

Summaries for Diabetic Ketoacidosis

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Diabetic ketoacidosis (DKA) is a potentially life-threatening complication in patients with diabetes... more...

MalaCards: Diabetic Ketoacidosis, also known as diabetes mellitus, ketosis-prone, is related to type 1 diabetes and diabetes mellitus. An important gene associated with Diabetic Ketoacidosis is PAX4 (paired box 4), and among its related pathways are GABA synthesis and Beta-alanine metabolism. The drugs insulin and insulin, aspart, human and the compounds norepinephrine and oxygen have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Description from OMIM:46 612227

Aliases & Classifications for Diabetic Ketoacidosis

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 9diseasecard, 46OMIM, 22GTR, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
See all sources

Aliases & Descriptions:

diabetic ketoacidosis 8 44 60
diabetes mellitus, ketosis-prone 8 9 46
ketosis-prone diabetes mellitus 8 22
diabetes mellitus, insulin-dependent 60


External Ids:

Disease Ontology8 DOID:1837
OMIM46 612227
ICD9CM27 250.1
MeSH34 D016883
NCIt39 C50530

Related Diseases for Diabetic Ketoacidosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diabetic Ketoacidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1type 1 diabetes31.4HNF4A, CTLA4, GAD2, GAD1, INS, TPO
2diabetes mellitus31.1AGER, SST, INS, PAX4, ADRB3, PIK3C2A
3pancreatitis30.8INS, SST
4metabolic acidosis30.7PIK3C2A, CHKB, BTD, AQP2
5acute pancreatitis30.6IL18, SST
6hyperglycemia30.6HNF4A, LSL, GAD2, GAD1, AGER, SST
7brain edema30.6CLDN5
8hypokalemia30.4PIK3C2A, INS, AQP2
9hypoglycemia30.4HNF4A, LSL, GAD1, SST, BTD, INS
10obesity30.4HNF4A, LSL, GAD2, AGER, INS, IL18
11hypertension30.4INS, ADRB3
12hepatitis30.4HNF4A, CTLA4, IL18
13type 2 diabetes mellitus30.3HNF4A, LSL, GAD2, GAD1, AGER, INS
14candidiasis30.2BTD
15neuropathy30.2INS, PIK3C2A
16thyroiditis30.2TPO, GAD2, CTLA4
17eating disorder30.2INS
18diabetic neuropathy30.2GAD2, GAD1, AGER, INS
19gestational diabetes30.2HNF4A, LSL, GAD1, INS, ADRB3
20myocardial infarction30.2LSL, TNNI3, PIK3C2A, AGER, CHKB, TPO
21hepatitis c30.2LSL, CTLA4, IL18
22anorexia nervosa30.0LSL
23pneumonia30.0PIK3C2A
24alopecia30.0BTD
25connective tissue disease30.0CTLA4
26down syndrome30.0TPO
27viral hepatitis30.0G6PD
28addison's disease30.0TPO, CTLA4
29cushing's syndrome30.0INS, SST
30cystic fibrosis30.0BTD, INS, AQP2
31ischemia30.0GAD2, GAD1, PIK3C2A, CHKB
32adenocarcinoma30.0HNF4A, SST, CLDN5
33arthritis30.0IL18, AGER, CTLA4
34duchenne muscular dystrophy30.0TNNI3, PIK3C2A, CHKB
35hypopituitarism30.0AQP2, INS, SST
36graves' disease30.0CTLA4, GAD2, GAD1, HLA-DQB1, TPO
37maturity-onset diabetes of the young30.0PAX4, INS, HNF4A
38adenoma30.0HNF4A, CTLA4, SST, INS, TPO
39rheumatoid arthritis30.0CTLA4, HLA-DQB1, AGER, CHKB, IL18
40cerebritis10.8
41type 1 diabetes mellitus10.5
42acromegaly10.5
43wolfram syndrome10.4
44epiphyseal dysplasia multiple with early-onset diabetes mellitus10.4
45diabetes mellitus, insulin-dependent, 1910.4
46diabetes mellitus, insulin-dependent, 710.4
47diabetes mellitus, insulin-dependent, 1310.4
48diabetes mellitus, insulin-dependent, 2210.4
49diabetes mellitus, insulin-dependent, 2310.4
50diabetes mellitus, insulin-dependent, 1810.4

Graphical network of the top 20 diseases related to Diabetic Ketoacidosis:



Diseases related to diabetic ketoacidosis

Clinical Features for Diabetic Ketoacidosis

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

612227

Clinical synopsis from OMIM:

612227

Genetic Tests for Diabetic Ketoacidosis

About this section
Sources:
22GTR
See all sources

Genetic tests related to Diabetic Ketoacidosis:

id Genetic test Affiliating Genes
1 Diabetes Mellitus, Ketosis-Prone22

Anatomical Context for Diabetic Ketoacidosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Diabetic Ketoacidosis:

32
Brain, Testes, Pituitary, Heart, Thyroid, Liver, Spinal cord, Monocytes, Endothelial, Bone, Small intestine, Pancreatic islet

Animal Models for Diabetic Ketoacidosis or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Diabetic Ketoacidosis

About this section
Sources:
50PubMed
See all sources

Articles related to Diabetic Ketoacidosis:

(show top 50)    (show all 628)
idTitleAuthorsYear
1
Diabetic ketoacidosis associated with acute pancreatitis in a heart transplant recipient treated with tacrolimus. (23075084)
2013
2
Spontaneous Pneumomediastinum in a Patient With Diabetic Ketoacidosis. (24139747)
2013
3
Recurrent diabetic ketoacidosis in two community teaching hospitals. (23757621)
2013
4
D-lactate: a novel contributor to metabolic acidosis and high anion gap in diabetic ketoacidosis. (23836843)
2013
5
Predictive value of capnography for suspected diabetic ketoacidosis in the emergency department. (24381677)
2013
6
The ratio of red cell distribution width to mean corpuscular volume in patients with diabetic ketoacidosis. (24273933)
2013
7
Cerebral hyperemia measured with near infrared spectroscopy during treatment of diabetic ketoacidosis in children. (23871731)
2013
8
Incidence and mortality of diabetic ketoacidosis in benghazi-libya in 2007. (23772283)
2013
9
Social determinants for recurrent diabetic ketoacidosis in children with diabetes. (22922210)
2012
10
Increased serum levels of ischemia-modified albumin and C-reactive protein in type 1 diabetes patients with ketoacidosis. (22437883)
2012
11
Diabetic Ketoacidosis in Acromegaly: A Case Report. (23186966)
2012
12
Change in mean transit time, apparent diffusion coefficient, and cerebral blood volume during pediatric diabetic ketoacidosis treatment. (21516055)
2011
13
Closing the anion gap: contribution of D-lactate to diabetic ketoacidosis. (21036159)
2011
14
An overview of diabetic ketoacidosis in children. (21473491)
2011
15
Positive predictive value of automated database records for diabetic ketoacidosis (DKA) in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid Study. (22112194)
2011
16
Current controversies in treatment and prevention of diabetic ketoacidosis. (21056741)
2010
17
Cerebral oedema in adult diabetic ketoacidosis: the importance of effective serum osmolality. (21209474)
2010
18
Frequency, clinical characteristics and outcome of diabetic ketoacidosis in children with type-1 diabetes at a tertiary care hospital. (21381577)
2010
19
Accuracy of a continuous glucose monitoring system in dogs and cats with diabetic ketoacidosis. (20636983)
2010
20
Duration of intravenous fluid therapy in children with diabetic ketoacidosis. (20091359)
2010
21
Is diabetic ketoacidosis at disease onset a result of missed diagnosis? (19962155)
2010
22
Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. (20028943)
2010
23
Fatal cerebral oedema in adult diabetic ketoacidosis. (20103820)
2010
24
Diabetic ketoacidosis presenting with emphysematous pyelonephritis. (19230719)
2010
25
Acidosis: the prime determinant of depressed sensorium in diabetic ketoacidosis. (20484127)
2010
26
Change in blood-brain barrier permeability during pediatric diabetic ketoacidosis treatment. (19838141)
2010
27
Beneficial use of sodium bicarbonate in comatose patients with diabetic ketoacidosis. (19898173)
2009
28
Inflammatory mediators and blood brain barrier disruption in fatal brain edema of diabetic ketoacidosis. (19103180)
2009
29
Blood glucose measurement in patients with suspected diabetic ketoacidosis: a comparison of Abbott MediSense PCx point-of-care meter values to reference laboratory values. (19285169)
2009
30
Diabetic ketoacidosis in toddler with a diaper rash. (18774050)
2008
31
Bicarbonate therapy in diabetic ketoacidosis. (19166130)
2008
32
Diabetic ketoacidosis. A preventable crisis. (17582867)
2007
33
Uncovering the basis of a severe degree of acidemia in a patient with diabetic ketoacidosis. (17971393)
2007
34
Neuroinflammatory response of the choroid plexus epithelium in fatal diabetic ketoacidosis. (17335802)
2007
35
Extrapontine myelinolysis in a 4 year old with diabetic ketoacidosis. (17425961)
2007
36
Diabetic ketoacidosis in an HIV-infected patient undergoing antiretroviral therapy]. (16513058)
2006
37
Managing diabetic ketoacidosis: the role of the ICU nurse in an endocrine emergency. (15460517)
2004
38
Early MRI findings of central pontine myelinolysis following "rapid" correction of hyponatraemia during diabetic ketoacidosis. A curious pontine lesion (2003:12b). (15035255)
2004
39
Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis. (14976569)
2003
40
Hypopituitarism following cerebral oedema with diabetic ketoacidosis. (12244015)
2002
41
Ketoacidosis accompanied by epileptic seizures in a patient with diabetes mellitus and mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). (11119021)
2000
42
Genital herpes and diabetic ketoacidosis: a patient report. (10587785)
1999
43
Severe diabetic ketoacidosis: the need for large doses of insulin. (10220211)
1999
44
Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxybutyrate concentration as the endpoint of emergency management. A randomized controlled study. (9283776)
1997
45
Acromegaly in a woman presenting with diabetic ketoacidosis and insulin resistance. (9536592)
1997
46
Insulin therapy for diabetic ketoacidosis. Bolus insulin injection versus continuous insulin infusion. (7587857)
1995
47
Alterations in monocyte receptor function in type 1 diabetic patients with ketoacidosis. (1828734)
1991
48
Malignant somatostatinoma presenting with diabetic ketoacidosis. (2822297)
1987
49
Acute adrenal insufficiency or diabetic ketoacidosis? (3116850)
1987
50
A case of pituitary gigantism who had two episodes of diabetic ketoacidosis followed by complete recovery of diabetes. (6420141)
1983

Genetic Variations for Diabetic Ketoacidosis

About this section

Expression for genes affiliated with Diabetic Ketoacidosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Ketoacidosis

Search GEO for disease gene expression data for Diabetic Ketoacidosis.

Pathways for genes affiliated with Diabetic Ketoacidosis

About this section
Sources:
53Reactome, 12EMD Millipore, 29KEGG, 37NCBI BioSystems Database, 49PharmGKB, 4Cell Signaling Technology, 51QIAGEN
See all sources

Compounds for genes affiliated with Diabetic Ketoacidosis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 49PharmGKB
See all sources

Compounds related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.6ADRB3, CHKB
2oxygen44 2411.2GAD1, PIK3C2A, ADRB3, TPO
3gemfibrozil44 28 1112.2INS, CHKB, PIK3C2A, G6PD
4hydrocortisone44 2 59 1113.2TPO, AQP2, INS, LSL
5dexamethasone44 49 28 1113.2HNF4A, CTLA4, INS, ADRB3, AQP2
6streptozotocin4410.2GAD1, AGER, SST, INS
7beta-hydroxybutyrate4410.1INS, CHKB, LSL
8bezafibrate44 28 1112.1HNF4A, PIK3C2A, CHKB, INS
9uric acid44 2411.1G6PD, PIK3C2A, CHKB, ADRB3, TPO
10olanzapine49 44 28 11 2414.1LSL, CHKB, INS, ADRB3
11methimazole44 2 1112.1LSL, G6PD, IL18, TPO
12malondialdehyde4410.0LSL, G6PD, PIK3C2A, AGER, CHKB
13acipimox44 2811.0INS, SST, LSL
14choline44 11 2412.0GAD2, GAD1, PIK3C2A, CHKB, SST
15acetylcholine44 49 28 11 2414.0CTLA4, GAD2, GAD1, SST, IL18, TPO
16prednisolone44 28 1112.0LSL, GAD1, PIK3C2A, CHKB, IL18
17potassium44 11 2412.0TNNI3, GAD1, PIK3C2A, ADRB3, AQP2, TPO
18hydrogen44 2411.0HNF4A, LSL, GAD1, CHKB, AQP2, TPO
19fatty acid449.9HNF4A, LSL, PIK3C2A, CHKB, BTD
20urea44 11 2411.9HNF4A, LSL, PIK3C2A, CHKB, ADRB3, AQP2
21cyclosporin a44 28 5911.8CTLA4, GAD2, GAD1, PIK3C2A, CHKB, IL18
22lithium44 49 11 2412.8HNF4A, LSL, AQP2, TPO
23acth449.8LSL, PIK3C2A, SST, INS, TPO
24glycerol44 11 2411.8HNF4A, LSL, G6PD, PIK3C2A, CHKB, INS
25glycogen44 2410.8HNF4A, PIK3C2A, CHKB, BTD, INS, ADRB3
26thyroxine44 2410.8LSL, G6PD, PIK3C2A, CHKB, SST, INS
27fibrinogen449.8LSL, PIK3C2A, CHKB, INS, IL18, TPO
28c-peptide449.7HNF4A, LSL, GAD2, GAD1, SST, INS
29adenylate449.7G6PD, CHKB, SST, IL18, ADRB3, AQP2
30glucose449.6AQP2, HNF4A, LSL, GAD2, GAD1, PIK3C2A
31aspartate449.5LSL, G6PD, GAD1, HLA-DQB1, PIK3C2A, CHKB
32cysteine449.5HNF4A, CTLA4, GAD2, GAD1, CHKB, BTD
33epinephrine44 11 2411.5LSL, G6PD, PIK3C2A, CHKB, SST, INS
34lactate449.5LSL, TNNI3, G6PD, PIK3C2A, CHKB, SST
35atp44 2810.5HNF4A, G6PD, GAD2, GAD1, PIK3C2A, CHKB
36steroid449.4HNF4A, LSL, CTLA4, GAD1, PIK3C2A, CHKB
37glutamine449.4HNF4A, G6PD, GAD1, HLA-DQB1, CHKB, IL18
38estrogen449.4HNF4A, LSL, CTLA4, G6PD, CHKB, INS
39oligonucleotide449.4HNF4A, GAD2, GAD1, HLA-DQB1, AGER, CLDN5
40testosterone44 59 11 2412.4HNF4A, LSL, G6PD, PIK3C2A, CHKB, SST
41nitric oxide44 11 2411.4HNF4A, LSL, GAD2, GAD1, AGER, CHKB
42methotrexate44 49 1111.3LSL, CTLA4, PIK3C2A, CHKB, IL18
43alanine449.3HNF4A, LSL, CTLA4, GAD2, GAD1, PIK3C2A
44creatinine449.2LSL, TNNI3, G6PD, GAD1, PIK3C2A, AGER
45glutamate449.2HNF4A, CTLA4, GAD2, GAD1, HLA-DQB1, PIK3C2A
46tyrosine449.2HNF4A, CTLA4, GAD2, GAD1, HLA-DQB1, PIK3C2A
47lipid449.2HNF4A, LSL, CTLA4, G6PD, PIK3C2A, AGER
48cholesterol44 28 11 2412.1HNF4A, LSL, CTLA4, GAD2, GAD1, PIK3C2A
49arginine449.0CHKB, PIK3C2A, GAD1, LSL, HNF4A, SST
50calcium44 49 11 2411.8GAD2, CTLA4, TNNI3, LSL, HNF4A, GAD1

GO Terms for genes affiliated with Diabetic Ketoacidosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneGO:0612029.9GAD1, GAD2
2plasma membraneGO:0058868.9GAD2, GAD1, HLA-DQB1, PIK3C2A, AGER, CLDN5

Biological processes related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate decarboxylation to succinateGO:00654010.2GAD1, GAD2
2response to drugGO:04249310.0PAX4, SST, GAD1, GAD2
3endocrine pancreas developmentGO:03101810.0PAX4, INS, HNF4A
4hyperosmotic responseGO:0069729.9SST, AQP2

Molecular functions related to Diabetic Ketoacidosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutamate bindingGO:01659510.2GAD1, GAD2
2glutamate decarboxylase activityGO:0043519.9GAD1, GAD2

Products for genes affiliated with Diabetic Ketoacidosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetic Ketoacidosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet