MCID: DBT006
MIFTS: 54

Diabetic Macular Edema malady

Eye diseases category

Summaries for Diabetic Macular Edema

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66Wikipedia, 34MalaCards
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Wikipedia:66 Diabetic retinopathy, ([?r?tn??p??i]) is retinopathy (damage to the retina) caused by complications of... more...

MalaCards: Diabetic Macular Edema is related to diabetic retinopathy and retinal detachment. An important gene associated with Diabetic Macular Edema is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are Immune response Oncostatin M signaling via JAK Stat in human cells and LDL Oxidation in Atherogenesis. The compounds olmesartan and perindopril have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are tumorigenesis and endocrine/exocrine gland.

Aliases & Classifications for Diabetic Macular Edema

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

diabetic macular edema 9 11 46 63


External Ids:

Disease Ontology9 DOID:9191
SNOMED-CT59 312912001
ICD9CM28 362.07

Related Diseases for Diabetic Macular Edema

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Diabetic Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic retinopathy30.9SERPINF1, SOD2, PRKCB, AKR1B1, ICAM1, DYT10
2retinal detachment30.9VEGFA, SERPINF1
3retinal vein occlusion30.7VEGFA
4proliferative diabetic retinopathy30.6SERPINF1, VEGFA, ICAM1, SST, CCL2, FGF2
5ischemia30.5VEGFA, ICAM1, FGF2, NOS3, SOD2, AKR1B1
6neuropathy30.3SOD2, AKR1B1, INS
7type 1 diabetes mellitus30.3PRKCB, SST, AKR1B1, INS
8blindness30.3INS, VEGFA, SERPINF1, PRKCB, AKR1B1
9diabetes mellitus30.1NOS3, DYT10, IL6, CCL2, SST, ICAM1
10retinitis11.0
11endotheliitis10.8
12cataract10.7
13age related macular degeneration10.6
14vitreous detachment10.6
15burns10.2
16macular holes10.2
17leukocoria10.2
18anterior ischemic optic neuropathy10.2
19ocular hypotension10.2
20sleep disorder10.2
21hypoxia10.2
22central retinal vein occlusion10.1VEGFA
23diabetic autonomic neuropathy10.1AKR1B1
24dengue shock syndrome10.1THBD
25hypoaldosteronism10.1REN
26gitelman syndrome10.1REN
27low renin hypertension10.1REN
28retinopathy of prematurity10.1VEGFA
29malaria10.1ICAM1
30diabetic cataract10.1AKR1B1
31angiodysplasia10.1SST
32dumping syndrome10.1SST
33leukostasis10.1ICAM1
34rheumatoid vasculitis10.1ICAM1
35zollinger-ellison syndrome10.1SST
36meningioma10.1SST
37macular retinal edema10.1VEGFA, SERPINF1, PRKCB
38ovarian hyperstimulation syndrome10.1REN, VEGFA
39poems syndrome10.1IL6, VEGFA
40allergic contact dermatitis10.1ICAM1, DYT10
41vascular cancer10.1VEGFA, FGF2
42pure autonomic failure10.1EPO, REN
43hypoglycemic coma10.1INS
44retinal vascular disease10.1DYT10, SERPINF1, VEGFA, AKR1B1
45corneal neovascularization10.1VEGFA, FGF2, SERPINF1
46hemangioblastoma10.1EPO, VEGFA
47peripheral vascular disease10.1INS
48glomerulosclerosis10.1CCL2, REN, AKR1B1
49retinal degeneration10.0FGF2, AKR1B1, SERPINF1
50lung adenocarcinoma10.0THBD, VEGFA, SOD2, DYT10

Graphical network of the top 20 diseases related to Diabetic Macular Edema:



Diseases related to diabetic macular edema

Symptoms for Diabetic Macular Edema

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Drugs & Therapeutics for Diabetic Macular Edema

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Macular Edema

Drug clinical trials:

Search ClinicalTrials for Diabetic Macular Edema

Search NIH Clinical Center for Diabetic Macular Edema

Search CenterWatch for Diabetic Macular Edema

Genetic Tests for Diabetic Macular Edema

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Anatomical Context for Diabetic Macular Edema

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34MalaCards
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MalaCards organs/tissues related to Diabetic Macular Edema:

34
Eye, Retina, Endothelial, Testes

Animal Models for Diabetic Macular Edema or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetic Macular Edema:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2VEGFA, SOD2, ICAM1, CCL2, IL6, FGF2
2MP:00053798.1NOS3, IL6, ICAM1, SERPINF1, VEGFA, INS
3MP:00053757.9INS, SOD2, CCL2, IL6, NOS3
4MP:00053677.9THBD, INS, VEGFA, SOD2, AKR1B1, REN
5MP:00028737.8THBD, INS, VEGFA, EPO, REN, SST
6MP:00053707.7THBD, INS, VEGFA, SOD2, EPO, CCL2
7MP:00053897.7THBD, INS, VEGFA, SERPINF1, SOD2, REN
8MP:00107717.7THBD, INS, VEGFA, SOD2, EPO, ICAM1
9MP:00053907.5INS, VEGFA, AKR1B1, CCL2, IL6, NOS3
10MP:00053817.5THBD, INS, VEGFA, SERPINF1, ICAM1, SST
11MP:00053697.3INS, VEGFA, SOD2, REN, ICAM1, CCL2
12MP:00053917.1INS, VEGFA, SERPINF1, SOD2, AKR1B1, ICAM1
13MP:00053876.9THBD, INS, VEGFA, SOD2, PRKCB, REN
14MP:00053846.8THBD, INS, VEGFA, SOD2, EPO, ICAM1
15MP:00053786.8THBD, INS, VEGFA, SOD2, AKR1B1, REN
16MP:00053976.5EPO, SOD2, VEGFA, INS, THBD, PRKCB
17MP:00107686.4EPO, SOD2, VEGFA, INS, THBD, AKR1B1
18MP:00053866.3AKR1B1, PRKCB, SOD2, VEGFA, INS, REN
19MP:00036316.3THBD, INS, VEGFA, SERPINF1, SOD2, PRKCB
20MP:00053856.3FGF2, THBD, INS, VEGFA, SERPINF1, SOD2
21MP:00053766.0PRKCB, EPO, SOD2, VEGFA, INS, THBD

Publications for Diabetic Macular Edema

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Sources:
53PubMed
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Articles related to Diabetic Macular Edema:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Single injection of triamcinolone versus three repeated injections of bevacizumab for treatment of diabetic macular edema. (23334618)
2013
2
Enzymatic vitrectomy for diabetic retinopathy and diabetic macular edema. (24379923)
2013
3
Factors affecting visual outcomes in patients with diabetic macular edema treated with ranibizumab. (24263379)
2013
4
Development of a Semi-Automatic Segmentation Method for Retinal OCT Images Tested in Patients with Diabetic Macular Edema. (24386127)
2013
5
NAVILAS Laser System Focal Laser Treatment for Diabetic Macular Edema - One Year Results of a Case Series. (24082979)
2013
6
Risk factors associated with diabetic macular edema. (23380134)
2013
7
Psychometric validation of the Visual Function Questionnaire-25 in patients with diabetic macular edema. (23347793)
2013
8
Paired responses to intravitreal bevacizumab in diabetic macular edema: predictors of response in the fellow eye. (23873254)
2013
9
Vascular endothelial growth factor gene polymorphism prevalence in patients with diabetic macular edema and its correlation with anti-VEGF treatment outcomes. (23927080)
2013
10
Diabetic macular edema: Current management 2013. (24379911)
2013
11
Subtenon injection of natural leukocyte interferon I+-2a in diabetic macular edema: a case report. (24165224)
2013
12
Lipoxins, resolvins, and protectins in the prevention and treatment of diabetic macular edema and retinopathy. (22677359)
2013
13
Diabetic macular edema: New promising therapies. (24379924)
2013
14
Ranibizumab injection for diabetic macular edema: meta-analysis of systemic safety and systematic review. (23931473)
2013
15
Classification of diabetic retinopathy and diabetic macular edema. (24379919)
2013
16
Intravitreal bevacizumab may increase diabetic macular edema in eyes with attached posterior vitreous. (23467022)
2013
17
Structural changes in individual retinal layers in diabetic macular edema. (24073417)
2013
18
Vitrectomy combined with intravitreal triamcinolone acetonide injection and macular laser photocoagulation for nontractional diabetic macular edema. (23730111)
2013
19
Optical coherence tomography in diabetic macular edema: patterns and related risk factors. (24172553)
2013
20
Two-year results of a randomized trial of intravitreal bevacizumab alone or combined with triamcinolone versus laser in diabetic macular edema. (22234244)
2012
21
Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema. (22727177)
2012
22
Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study. (22589436)
2012
23
Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study). (23074206)
2012
24
Evaluation of a Novel, Non Contact, Automated Focal Laser with Integrated (NAVILAS) Fluorescein Angiography for Diabetic Macular Edema. (22346133)
2012
25
Factors associated with changes in visual acuity and central subfield thickness at 1 year after treatment for diabetic macular edema with ranibizumab. (22965591)
2012
26
Intravitreal injection of commercially available ketorolac tromethamine in eyes with diabetic macular edema refractory to laser photocoagulation. (21780926)
2011
27
Visual outcome after intravitreal triamcinolone acetonide depends on optical coherence tomographic patterns in patients with diffuse diabetic macular edema. (21836404)
2011
28
Comparison of intravitreal bevacizumab and ranibizumab treatment for diabetic macular edema. (21631366)
2011
29
Imaging of diabetic retinopathy and diabetic macular edema. (21607565)
2011
30
Correlation of macular thickness and posterior hyaloid change following bevacizumab and triamcinolone in diffuse diabetic macular edema in middle-aged patients. (21979875)
2011
31
Macular thickness changes after phacoemulsification in previously vitrectomized eyes for diabetic macular edema. (21293315)
2011
32
Targeting the pathophysiology of diabetic macular edema. (20980428)
2010
33
Effect of retinal photocoagulation on intraretinal lipid exudates in diabetic macular edema documented by optical coherence tomography. (20079541)
2010
34
Pattern electroretinogram changes after intravitreal bevacizumab injection for diabetic macular edema. (20140695)
2010
35
Correlation between visual acuity and foveal microstructural changes in diabetic macular edema. (19996821)
2010
36
Polyunsaturated Fatty Acid Composition of Surgically Removed Hard Exudates in Diabetic Macular Edema. (20337342)
2010
37
Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema. (20212197)
2010
38
Dose dependent effects of intravitreal triamcinolone acetonide on diffuse diabetic macular edema. (19568355)
2009
39
Diabetic macular edema. (23960851)
2009
40
Update on laser treatment of diabetic macular edema. (19349789)
2009
41
Intravitreal combination of triamcinolone acetonide and bevacizumab (Kenacort-Avastin) in diffuse diabetic macular edema. (19954371)
2009
42
Effect of vitrectomy on macular microcirculation in patients with diffuse diabetic macular edema. (19294405)
2009
43
Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema. (18708615)
2009
44
Diabetic macular edema. (19729104)
2009
45
The article by Kook et al 1 on the 1-year effect of bevacizumab in patients with chronic diffuse diabetic macular edema (DME). (19430285)
2009
46
Prevention of vision loss after cataract surgery in diabetic macular edema with intravitreal bevacizumab: a pilot study. (19357559)
2009
47
Surgical and anatomical outcomes of pars plana vitrectomy for diffuse nontractional diabetic macular edema. (18327133)
2008
48
Comparative therapy evaluation of intravitreal bevacizumab and triamcinolone acetonide on persistent diffuse diabetic macular edema. (19027427)
2008
49
Vitreous surgery for diabetic macular edema--its prognosis and correlation between preoperative systemic and ocular conditions and visual outcome. (18025629)
2007
50
Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. (13129863)
2003

Variations for Diabetic Macular Edema

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Expression for genes affiliated with Diabetic Macular Edema

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Macular Edema

Search GEO for disease gene expression data for Diabetic Macular Edema.

Pathways for genes affiliated with Diabetic Macular Edema

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Sources:
51PathCards, 61Thomson Reuters, 54QIAGEN, 5Cell Signaling Technology, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 52PharmGKB, 58SinoBiological, 55R&D Systems, 13EMD Millipore
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Pathways related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CCL2, VEGFA
29.8CCL2, ICAM1
3
Show member pathways
Angiogenesis39
9.4FGF2, NOS3, VEGFA
49.3VEGFA, SST, IL6
59.3REN, NOS3, FGF2
6
Show member pathways
9.3NOS3, PRKCB, VEGFA, THBD
79.3IL6, ICAM1, PRKCB
89.3NOS3, PRKCB, INS
9
Show member pathways
9.2FGF2, NOS3, PRKCB, VEGFA
109.1ICAM1, CCL2, IL6
119.1IL6, CCL2, ICAM1
129.1IL6, CCL2, ICAM1
13
Show member pathways
Signaling Pathways in Glioblastoma39
9.1INS, VEGFA, PRKCB, FGF2
14
Show member pathways
9.1INS, VEGFA, PRKCB, FGF2
15
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.1IL6, PRKCB, INS
169.1THBD, INS, IL6
17
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
9.0INS, SOD2, IL6
18
Show member pathways
9.0VEGFA, SOD2, EPO, IL6
199.0FGF2, IL6, PRKCB, VEGFA
208.9VEGFA, ICAM1, CCL2, IL6
21
Show member pathways
8.9IL6, CCL2, ICAM1, PRKCB
22
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
8.9VEGFA, PRKCB, ICAM1, CCL2, NOS3
238.8NOS3, IL6, CCL2, THBD
24
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6CCL2, IL6, NOS3, FGF2
25
Show member pathways
thioredoxin pathway39
8.3INS, SOD2, ICAM1, CCL2, IL6
26
Show member pathways
8.3INS, REN, CCL2, IL6, FGF2
27
Show member pathways
8.2FGF2, IL6, CCL2, EPO, INS
288.1NOS3, IL6, PRKCB, EPO, VEGFA, INS
297.9INS, VEGFA, EPO, IL6, NOS3, FGF2
30
Show member pathways
7.5INS, VEGFA, SERPINF1, SOD2, EPO, CCL2

Compounds for genes affiliated with Diabetic Macular Edema

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
See all sources

Compounds related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 224)
idCompoundScoreTop Affiliating Genes
1olmesartan46 30 1211.5INS, CCL2, REN, SERPINF1
2perindopril46 52 1211.5NOS3, REN, VEGFA, THBD
3aminoguanidine46 30 1211.4AKR1B1, SOD2, NOS3, EPO
4streptozotocin469.1INS, SERPINF1, SST, NOS3, AKR1B1
5gm-csf46 3010.0EPO, ICAM1, CCL2, IL6, VEGFA
6cyclophosphamide46 52 1210.9NOS3, THBD, VEGFA, SOD2, SST, CCL2
7bleomycin46 129.8FGF2, NOS3, CCL2, EPO, SOD2
8thalidomide46 52 62 1211.8EPO, FGF2, IL6, VEGFA, THBD
9ang ii468.7NOS3, DYT10, CCL2, REN, VEGFA
10fluvastatin46 52 30 1211.7IL6, NOS3, CCL2, THBD, ICAM1
11nadph46 259.7THBD, SERPINF1, SOD2, PRKCB, CCL2, NOS3
1215-deoxy-delta-12,14-prostaglandin j2468.7CCL2, NOS3, FGF2, IL6, VEGFA
13atorvastatin46 52 30 25 1212.6NOS3, IL6, THBD, VEGFA, CCL2, ICAM1
14prostacyclin468.6CCL2, ICAM1, NOS3, REN, FGF2, VEGFA
15curcumin468.6THBD, IL6, AKR1B1, VEGFA, ICAM1, CCL2
16ascorbic acid46 259.6EPO, THBD, NOS3, SOD2, AKR1B1, FGF2
17simvastatin46 52 62 30 25 1213.5THBD, VEGFA, ICAM1, CCL2, IL6, NOS3
18calcitriol46 62 25 1211.5PRKCB, SOD2, THBD, IL6, EPO, REN
19fenofibrate46 52 1210.5NOS3, INS, IL6, ICAM1, CCL2
20gf 109203x46 629.5PRKCB, VEGFA, DYT10, FGF2, SOD2, NOS3
21polymyxin b468.5IL6, THBD, DYT10, CCL2, ICAM1
22hydrocortisone46 3 62 1211.4EPO, REN, INS, FGF2, IL6, SST
238-isoprostane468.3THBD, ICAM1, IL6, CCL2, NOS3, INS
24pravastatin46 52 30 25 1212.3CCL2, NOS3, IL6, ICAM1, THBD
25vitamin d468.3THBD, SOD2, EPO, IL6, PRKCB, CCL2
26matrigel468.3NOS3, THBD, ICAM1, FGF2, SERPINF1, VEGFA
27pdtc468.3SOD2, ICAM1, CCL2, IL6, DYT10
28epinephrine46 25 1210.2INS, SOD2, AKR1B1, REN, SST, IL6
29diphenyleneiodonium468.2SOD2, ICAM1, CCL2, VEGFA, DYT10, SERPINF1
30norepinephrine46 25 1210.2REN, AKR1B1, SOD2, INS, SST, CCL2
31cyclosporin a46 30 6210.2SOD2, THBD, ICAM1, PRKCB, IL6, AKR1B1
32gnrh468.1DYT10, CCL2, SST, PRKCB, EPO, INS
33lactate468.0THBD, AKR1B1, EPO, SOD2, INS, ICAM1
34arginine467.8INS, SOD2, AKR1B1, REN, SST, NOS3
35nitric oxide46 25 129.8CCL2, REN, IL6, PRKCB, SOD2, THBD
36n acetylcysteine467.8CCL2, ICAM1, AKR1B1, SERPINF1, SOD2, IL6
37creatinine467.8INS, AKR1B1, EPO, IL6, CCL2, REN
38h2o2467.8FGF2, SERPINF1, SOD2, THBD, AKR1B1, ICAM1
39glucose467.8SERPINF1, IL6, CCL2, THBD, INS, PRKCB
40sb 20358046 628.6VEGFA, FGF2, NOS3, DYT10, IL6, CCL2
41retinoic acid46 258.1THBD, SERPINF1, PRKCB, ICAM1, SST, DYT10
42dexamethasone46 52 30 1210.1FGF2, THBD, INS, IL6, CCL2, SST
43pge2467.1AKR1B1, REN, ICAM1, SST, VEGFA, IL6
44cycloheximide467.0VEGFA, THBD, SOD2, AKR1B1, ICAM1, SST
45phosphatidylinositol467.0NOS3, INS, EPO, PRKCB, ICAM1, CCL2
46actinomycin d466.9CCL2, IL6, DYT10, NOS3, FGF2, ICAM1
47genistein46 30 62 3 25 1211.9CCL2, VEGFA, SST, SOD2, NOS3, AKR1B1
48tyrosine466.6VEGFA, FGF2, DYT10, IL6, ICAM1, PRKCB
49ly294002466.6DYT10, ICAM1, INS, VEGFA, SOD2, EPO
50vegf465.6VEGFA, THBD, SERPINF1, EPO, DYT10, NOS3

GO Terms for genes affiliated with Diabetic Macular Edema

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Sources:
17Gene Ontology
See all sources

Cellular components related to Diabetic Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.2VEGFA, SERPINF1, EPO, REN, SST, CCL2
2extracellular spaceGO:0056156.1FGF2, THBD, INS, VEGFA, SERPINF1, EPO

Biological processes related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.2PRKCB, VEGFA
2C21-steroid hormone biosynthetic processGO:00670010.1AKR1B1, FGF2
3response to hyperoxiaGO:05509310.1EPO, SOD2
4kidney developmentGO:00182210.1VEGFA, SERPINF1, REN
5cell migration involved in sprouting angiogenesisGO:00204210.0FGF2, VEGFA
6negative regulation of platelet activationGO:01054410.0THBD, NOS3
7positive regulation of blood vessel endothelial cell migrationGO:04353610.0VEGFA, FGF2
8positive regulation of protein autophosphorylationGO:0319549.9INS, VEGFA
9negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressGO:19021769.9INS, SOD2
10negative regulation of calcium ion transportGO:0519269.9NOS3, ICAM1
11cellular response to hypoxiaGO:0714569.9VEGFA, EPO, ICAM1
12response to axon injuryGO:0486789.8FGF2, EPO, SOD2
13regulation of vascular endothelial growth factor productionGO:0105749.8IL6, CCL2
14positive regulation of endothelial cell proliferationGO:0019389.8VEGFA, CCL2, FGF2
15regulation of blood pressureGO:0082179.8NOS3, REN, SOD2
16lung developmentGO:0303249.7FGF2, NOS3, VEGFA
17response to electrical stimulusGO:0516029.6SOD2, EPO, IL6
18negative regulation of gluconeogenesisGO:0457219.6IL6, INS
19response to glucocorticoidGO:0513849.6IL6, CCL2, SERPINF1
20vascular endothelial growth factor receptor signaling pathwayGO:0480109.6CCL2, VEGFA
21positive regulation of angiogenesisGO:0457669.6FGF2, NOS3, PRKCB, VEGFA
22monocyte chemotaxisGO:0025489.5CCL2, IL6
23response to hypoxiaGO:0016669.5VEGFA, SOD2, CCL2
24regulation of angiogenesisGO:0457659.4FGF2, IL6
25positive regulation of DNA replicationGO:0457409.4IL6, EPO, INS
26agingGO:0075689.3SERPINF1, EPO, CCL2, IL6
27blood coagulationGO:0075969.3NOS3, PRKCB, VEGFA, THBD
28regulation of cell shapeGO:0083609.3VEGFA, ICAM1, CCL2, IL6
29response to amino acidGO:0432009.3IL6, CCL2, SST, ICAM1
30positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2IL6, ICAM1, VEGFA, INS
31positive regulation of NF-kappaB transcription factor activityGO:0510929.1INS, PRKCB, ICAM1, IL6
32response to lipopolysaccharideGO:0324969.1IL6, REN, EPO, SOD2, THBD
33response to heatGO:0094089.1SST, CCL2, IL6, NOS3
34positive regulation of nitric oxide biosynthetic processGO:0454299.1INS, SOD2, ICAM1, IL6
35response to drugGO:0424938.9IL6, CCL2, SST, ICAM1, SOD2
36negative regulation of cell proliferationGO:0082858.8SOD2, SST, IL6, NOS3, FGF2
37positive regulation of cell proliferationGO:0082848.7INS, VEGFA, EPO, IL6, FGF2

Molecular functions related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.8VEGFA, FGF2
2insulin-like growth factor receptor bindingGO:0051599.8REN, INS
3heparin bindingGO:0082019.5FGF2, CCL2, VEGFA
4hormone activityGO:0051799.4INS, EPO, SST
5cytokine activityGO:0051259.2FGF2, IL6, VEGFA
6growth factor activityGO:0080838.9FGF2, IL6, VEGFA
7protein bindingGO:0055156.5FGF2, THBD, INS, VEGFA, EPO, PRKCB

Products for genes affiliated with Diabetic Macular Edema

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetic Macular Edema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet