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Diabetic Macular Edema malady

Summaries for Diabetic Macular Edema

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic retinopathy, ([ˌrɛtnˈɑpəθi]) is retinopathy (damage to the retina) caused by... more...

MalaCards: Diabetic Macular Edema is related to macular retinal edema and diabetic retinopathy. An important gene associated with Diabetic Macular Edema is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are VEGF Signaling Pathway and Angiogenesis. The compounds cycloheximide and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are integument and nervous system.

Aliases & Classifications for Diabetic Macular Edema

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

diabetic macular edema 8 10 44 60


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Disease Ontology8 DOID:9191
SNOMED-CT56 312912001
ICD9CM27 362.07

Related Diseases for Diabetic Macular Edema

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1macular retinal edema31.5SERPINF1, VEGFA, PRKCB
2diabetic retinopathy31.2AKR1B1, DYT10, ICAM1, SOD2, PRKCB, VEGFA
3cataract30.9SERPINF1, AKR1B1
4age related macular degeneration30.8VEGFA
5retinal detachment30.6SERPINF1, VEGFA
6proliferative diabetic retinopathy30.6VEGFA, SERPINF1, SST, ICAM1, CCL2, FGF2
7retinal vein occlusion30.6VEGFA
8ischemia30.5NOS3, FGF2, VEGFA, AKR1B1, DYT10, ICAM1
9diabetes mellitus30.5AKR1B1, REN, SST, SOD2, ICAM1, CCL2
10neuropathy30.2SOD2, AKR1B1
11retinal degeneration30.2AKR1B1, FGF2, SERPINF1
12retinitis11.0
13diabetic cataract10.6
14vitreous detachment10.5
15cystoid macular edema10.4
16central retinal vein occlusion10.3
17sleep disorder10.3
18burns10.1
19central retinal artery occlusion10.1
20retinal ischemia10.1
21retinal microaneurysm10.1
22ischemic neuropathy10.1
23macular holes10.1
24leukocoria10.1
25type 1 diabetes mellitus10.1
26ischemic optic neuropathy10.1
27diabetic neuropathy10.1
28ocular hypotension10.1
29retinal artery occlusion10.1
30retinopathy of prematurity10.0VEGFA
31colorectal cancer10.0VEGFA
32endometrial carcinoma10.0VEGFA
33polyneuropathy10.0AKR1B1
34cervical cancer10.0DYT10
35diabetic polyneuropathy10.0AKR1B1
36cystic fibrosis10.0DYT10
37acute myocardial infarction10.0THBD
38von hippel-lindau disease10.0VEGFA
39lupus erythematosus10.0THBD
40stroke, ischemic10.0THBD
41senile cataract10.0SERPINF1
42dilated cardiomyopathy10.0DYT10
43sarcoma10.0SOD2
44hepatitis10.0SOD2
45eclampsia10.0THBD
46congestive heart failure10.0REN
47hepatitis c10.0SOD2
48dengue shock syndrome10.0THBD
49esophagitis10.0SOD2
50varicose veins10.0SST

Graphical network of the top 20 diseases related to Diabetic Macular Edema:



Diseases related to diabetic macular edema

Clinical Features for Diabetic Macular Edema

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Drugs & Therapeutics for Diabetic Macular Edema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Macular Edema

Drug clinical trials:

Search ClinicalTrials for Diabetic Macular Edema

Search NIH Clinical Center for Diabetic Macular Edema

Search CenterWatch for Diabetic Macular Edema

Genetic Tests for Diabetic Macular Edema

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Anatomical Context for Diabetic Macular Edema

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32MalaCards
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MalaCards organs/tissues related to Diabetic Macular Edema:

32
Eye, Retina, Endothelial, Testes

Animal Models for Diabetic Macular Edema or affiliated genes

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36MGI
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Publications for Diabetic Macular Edema

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50PubMed
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Articles related to Diabetic Macular Edema:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Subthreshold laser therapy for diabetic macular edema: metabolic and safety issues. (23745552)
2013
2
Combined vitrectomy and intravitreal injection versus combined laser and injection for treatment of intractable diffuse diabetic macular edema. (23440389)
2013
3
Communications between intraretinal and subretinal space on optical coherence tomography of neurosensory retinal detachment in diabetic macular edema. (24379554)
2013
4
Localized changes in retinal vessel caliber after focal/grid laser treatment in patients with diabetic macular edema: a measure of treatment response? (23514802)
2013
5
Long-term effectiveness of ranibizumab for age-related macular degeneration and diabetic macular edema. (23766636)
2013
6
Combined therapy for diabetic macular edema. (24339681)
2013
7
Intravitreal bevacizumab treatment for refractory diabetic macular edema. (23508574)
2013
8
Efficacy and safety of the intravitreal treatment of diabetic macular edema with pegaptanib: a 12-month follow-up. (23698213)
2013
9
Baseline central macular thickness predicts the need for retreatment with intravitreal triamcinolone plus laser photocoagulation for diabetic macular edema. (23946643)
2013
10
Three-dimensional imaging of the inner limiting membrane folding on the vitreomacular interface in diabetic macular edema. (24113997)
2013
11
Intravitreal fasudil combined with bevacizumab for persistent diabetic macular edema: a novel treatment. (23640178)
2013
12
Reproducibility of diabetic macular edema estimates from SD-OCT is affected by the choice of image analysis algorithm. (23696607)
2013
13
Management Paradigms for Diabetic Macular Edema. (24269850)
2013
14
Patient-reported visual function outcomes improve after ranibizumab treatment in patients with vision impairment due to diabetic macular edema: randomized clinical trial. (23974915)
2013
15
ASSOCIATION BETWEEN RETINAL VENULAR DILATION AND SEROUS RETINAL DETACHMENT IN DIABETIC MACULAR EDEMA. (23975002)
2013
16
Fully automatic software for retinal thickness in eyes with diabetic macular edema from images acquired by cirrus and spectralis systems. (24084089)
2013
17
Factors associated with changes in visual acuity and central subfield thickness at 1 year after treatment for diabetic macular edema with ranibizumab. (22965591)
2012
18
Comparison of intravitreal bevacizumab alone or combined with triamcinolone versus triamcinolone in diabetic macular edema: a randomized clinical trial. (21997197)
2012
19
The effect of glycemic control on visual and anatomic outcomes in response to therapy for diabetic macular edema. (22653762)
2012
20
Visual outcome after intravitreal triamcinolone acetonide depends on optical coherence tomographic patterns in patients with diffuse diabetic macular edema. (21836404)
2011
21
Correlation of macular thickness and posterior hyaloid change following bevacizumab and triamcinolone in diffuse diabetic macular edema in middle-aged patients. (21979875)
2011
22
The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema. (21696702)
2011
23
Better outcomes for patients with diabetic macular edema. (21459213)
2011
24
Foveal cystoid spaces are associated with enlarged foveal avascular zone and microaneurysms in diabetic macular edema. (20656355)
2011
25
Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients. (21487341)
2011
26
Update on nonsurgical therapy for diabetic macular edema. (21427573)
2011
27
The DA VINCI Study: phase 2 primary results of VEGF Trap-Eye in patients with diabetic macular edema. (21546089)
2011
28
Targeting the pathophysiology of diabetic macular edema. (20980428)
2010
29
Effect of retinal photocoagulation on intraretinal lipid exudates in diabetic macular edema documented by optical coherence tomography. (20079541)
2010
30
Effects of intravitreal erythropoietin therapy for patients with chronic and progressive diabetic macular edema. (20128565)
2010
31
Intravitreal triamcinolone as an adjunct to standard laser therapy in coexisting high-risk proliferative diabetic retinopathy and clinically significant macular edema. (20057344)
2010
32
Dose dependent effects of intravitreal triamcinolone acetonide on diffuse diabetic macular edema. (19568355)
2009
33
Intravitreal combination of triamcinolone acetonide and bevacizumab (Kenacort-Avastin) in diffuse diabetic macular edema. (19954371)
2009
34
The article by Kook et al 1 on the 1-year effect of bevacizumab in patients with chronic diffuse diabetic macular edema (DME). (19430285)
2009
35
The effect of unilateral intravitreal bevacizumab (avastin), in the treatment of diffuse bilateral diabetic macular edema: a pilot study. (18784623)
2009
36
Primary treatment of diabetic macular edema. (19503772)
2009
37
Triamcinolone-assisted removal of internal limiting membrane enhances the effect of vitrectomy for diabetic macular edema. (19451733)
2009
38
Concentration gradient of vascular endothelial growth factor in the vitreous of eyes with diabetic macular edema. (19060271)
2009
39
Is multifocal ERG a reliable index of macular function after triamcinolone acetonide injection in diffuse diabetic macular edema? (19882573)
2009
40
Comparison of surgical procedures for vitreous surgery in diabetic macular edema. (19333695)
2009
41
Effect of focal/grid photocoagulation on visual acuity and retinal thickening in eyes with non-center-involved diabetic macular edema. (19373126)
2009
42
Analysis of the effect of intravitreal bevacizumab injection on diabetic macular edema after cataract surgery. (19376589)
2009
43
Efficacy of 1.25 MG versus 2.5 MG intravitreal bevacizumab for diabetic macular edema: six-month results of a randomized controlled trial. (19287286)
2009
44
Posterior juxtascleral infusion of modified triamcinolone acetonide formulation for refractory diabetic macular edema: one-year follow-up. (19117937)
2009
45
Retinal thickness measurement and evaluation of natural history of the diabetic macular edema through optical coherence tomography. (19820779)
2009
46
Large-spot subthreshold infrared laser to treat diabetic macular edema. (18398365)
2008
47
Vascular endothelial growth factor is a critical stimulus for diabetic macular edema. (17046701)
2006
48
Diabetic macular edema: classification, medical and laser therapy. (15513012)
2003
49
Aggravation of laser-treated diabetic cystoid macular edema after prolonged flight: a case report. (7619038)
1995
50
Erythropoietin in diabetic macular edema and renal insufficiency. (7611253)
1995

Genetic Variations for Diabetic Macular Edema

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Expression for genes affiliated with Diabetic Macular Edema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Macular Edema

Search GEO for disease gene expression data for Diabetic Macular Edema.

Pathways for genes affiliated with Diabetic Macular Edema

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49PharmGKB, 55SinoBiological, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Diabetic Macular Edema

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7SOD2
2gm-csf44 2811.6ICAM1
3bleomycin44 1111.6FGF2
4matrigel4410.6NOS3
5pge24410.3SST, VEGFA, REN
6diphenyleneiodonium4410.2SOD2, SERPINF1, DYT10
7perindopril44 49 1112.0REN, VEGFA, THBD, NOS3
8nadph44 2411.0PRKCB, SOD2, MGST1
9aminoguanidine44 28 1111.9NOS3, EPO, AKR1B1, SOD2
10olmesartan44 28 1111.9SERPINF1, REN, CCL2
11clonidine44 28 1111.9SST, FGF2, REN
12candesartan44 28 1111.8VEGFA, NOS3, CCL2, REN
13apocynin44 5910.8NOS3, VEGFA, DYT10, ICAM1
14dexamethasone44 49 28 1112.8SOD2, REN, FGF2, VEGFA, SERPINF1
15nitroglycerin44 1110.8SST, REN, NOS3, SOD2
16streptozotocin449.8SERPINF1, AKR1B1, SST, NOS3
178-isoprostane449.7NOS3, THBD, ICAM1, CCL2
18cyclophosphamide44 49 1111.7SST, THBD, NOS3, SOD2
19go 697644 5910.7PRKCB, ICAM1, CCL2, DYT10
20polymyxin b449.7ICAM1, DYT10, CCL2, THBD
21cyclosporin a44 28 5911.7ICAM1, AKR1B1, PRKCB, THBD, FGF2
22mannitol44 1110.7AKR1B1, ICAM1, SLC6A6
23creatinine449.7REN, EPO, PRKCB, AKR1B1, THBD
24cerivastatin44 49 28 1112.7REN, NOS3, ICAM1, CCL2
25aldose449.6PRKCB, AKR1B1, SOD2, SLC6A6
26atorvastatin44 49 28 11 2413.6ICAM1, VEGFA, THBD, NOS3, CCL2
27ang ii449.5VEGFA, CCL2, NOS3, REN, DYT10
28citrate449.5NOS3, AKR1B1, FGF2, SOD2, THBD
29curcumin449.5CCL2, SOD2, ICAM1, VEGFA, THBD, AKR1B1
30calcitriol44 59 11 2412.5FGF2, REN, EPO, PRKCB, SOD2, THBD
31simvastatin44 49 59 28 11 2414.5CCL2, VEGFA, NOS3, ICAM1, THBD
3215-deoxy-delta-12,14-prostaglandin j2449.4NOS3, FGF2, VEGFA, CCL2
33gf 109203x44 5910.4NOS3, PRKCB, SOD2, DYT10, VEGFA, FGF2
34fluvastatin44 49 28 1112.3NOS3, THBD, CCL2, ICAM1
35vitamin d449.2EPO, PRKCB, SOD2, THBD, NOS3, CCL2
36n acetylcysteine449.2AKR1B1, CCL2, ICAM1, SOD2, SERPINF1, DYT10
37ascorbic acid44 2410.2FGF2, ICAM1, THBD, SOD2, AKR1B1, EPO
38oxygen44 2410.1EPO, CCL2, ICAM1, AKR1B1, SERPINF1, PRKCB
39prostacyclin449.1REN, NOS3, CCL2, ICAM1, THBD, VEGFA
40sb 20358044 5910.1DYT10, VEGFA, FGF2, ICAM1, CCL2, NOS3
41h2o2448.9SERPINF1, THBD, FGF2, AKR1B1, MGST1, ICAM1
42phosphatidylcholine448.8DYT10, THBD, FGF2, PRKCB, CCL2
43ly294002448.7VEGFA, EPO, CCL2, SOD2, NOS3, ICAM1
44actinomycin d448.6THBD, FGF2, VEGFA, ICAM1, DYT10, SOD2
45arginine448.6MGST1, NOS3, CCL2, AKR1B1, SST, REN
46genistein44 28 59 2 11 2413.6VEGFA, AKR1B1, DYT10, SST, ICAM1, CCL2
47retinoic acid44 249.5PRKCB, DYT10, ICAM1, SERPINF1, NOS3, THBD
48nitric oxide44 11 2410.4SERPINF1, REN, SLC6A6, PRKCB, THBD, NOS3
49tyrosine447.8ICAM1, DYT10, PRKCB, MGST1, VEGFA, TYRO3
50vegf447.0REN, NOS3, THBD, FGF2, EPO, SST

GO Terms for genes affiliated with Diabetic Macular Edema

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16Gene Ontology
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Cellular components related to Diabetic Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8CCL2, VEGFA, SST, EPO, REN, FGF2
2extracellular spaceGO:0056158.0CCL2, ICAM1, AKR1B1, VEGFA, SST, EPO

Biological processes related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1C21-steroid hormone biosynthetic processGO:00670010.1FGF2, AKR1B1
2negative regulation of platelet activationGO:01054410.1NOS3, THBD
3response to axon injuryGO:04867810.0SOD2, EPO, FGF2
4response to amino acid stimulusGO:0432009.9CCL2, ICAM1, SST
5regulation of blood pressureGO:0082179.9NOS3, REN, SOD2
6positive regulation of endothelial cell proliferationGO:0019389.9CCL2, VEGFA, FGF2
7response to heatGO:0094089.9NOS3, SST, CCL2
8negative regulation of calcium ion transportGO:0519269.8ICAM1, NOS3
9positive regulation of angiogenesisGO:0457669.8NOS3, FGF2, VEGFA, PRKCB
10lung developmentGO:0303249.8VEGFA, FGF2, NOS3
11cellular response to hypoxiaGO:0714569.8EPO, VEGFA, ICAM1
12response to hyperoxiaGO:0550939.7EPO, SOD2
13negative regulation of neuron apoptotic processGO:0435249.5TYRO3, SOD2, CCL2
14response to lipopolysaccharideGO:0324969.5SOD2, MGST1, EPO, REN
15response to drugGO:0424939.2CCL2, SOD2, ICAM1, MGST1, SST

Products for genes affiliated with Diabetic Macular Edema

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetic Macular Edema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet