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Diabetic Macular Edema malady

Summaries for Diabetic Macular Edema

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic retinopathy, ([ˌrɛtnˈɑpəθi]) is retinopathy (damage to the retina) caused by... more...

MalaCards: Diabetic Macular Edema is related to macular retinal edema and diabetic retinopathy. An important gene associated with Diabetic Macular Edema is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are VEGF Signaling Pathway and Angiogenesis. The compounds cycloheximide and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are integument and nervous system.

Aliases & Classifications for Diabetic Macular Edema

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

diabetic macular edema 8 10 44 60


External Ids:

Disease Ontology8 DOID:9191
SNOMED-CT56 312912001
ICD9CM27 362.07

Related Diseases for Diabetic Macular Edema

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1macular retinal edema31.5SERPINF1, VEGFA, PRKCB
2diabetic retinopathy31.2AKR1B1, DYT10, ICAM1, SOD2, PRKCB, VEGFA
3cataract30.9SERPINF1, AKR1B1
4age related macular degeneration30.8VEGFA
5retinal detachment30.6SERPINF1, VEGFA
6proliferative diabetic retinopathy30.6VEGFA, SERPINF1, SST, ICAM1, CCL2, FGF2
7retinal vein occlusion30.6VEGFA
8ischemia30.5NOS3, FGF2, VEGFA, AKR1B1, DYT10, ICAM1
9diabetes mellitus30.5AKR1B1, REN, SST, SOD2, ICAM1, CCL2
10neuropathy30.2SOD2, AKR1B1
11retinal degeneration30.2AKR1B1, FGF2, SERPINF1
12retinitis11.0
13diabetic cataract10.6
14vitreous detachment10.5
15cystoid macular edema10.4
16central retinal vein occlusion10.3
17sleep disorder10.3
18burns10.1
19central retinal artery occlusion10.1
20retinal ischemia10.1
21retinal microaneurysm10.1
22ischemic neuropathy10.1
23macular holes10.1
24leukocoria10.1
25type 1 diabetes mellitus10.1
26ischemic optic neuropathy10.1
27diabetic neuropathy10.1
28ocular hypotension10.1
29retinal artery occlusion10.1
30retinopathy of prematurity10.0VEGFA
31colorectal cancer10.0VEGFA
32endometrial carcinoma10.0VEGFA
33polyneuropathy10.0AKR1B1
34cervical cancer10.0DYT10
35diabetic polyneuropathy10.0AKR1B1
36cystic fibrosis10.0DYT10
37acute myocardial infarction10.0THBD
38von hippel-lindau disease10.0VEGFA
39lupus erythematosus10.0THBD
40stroke, ischemic10.0THBD
41senile cataract10.0SERPINF1
42dilated cardiomyopathy10.0DYT10
43sarcoma10.0SOD2
44hepatitis10.0SOD2
45eclampsia10.0THBD
46congestive heart failure10.0REN
47hepatitis c10.0SOD2
48dengue shock syndrome10.0THBD
49esophagitis10.0SOD2
50varicose veins10.0SST

Graphical network of the top 20 diseases related to Diabetic Macular Edema:



Diseases related to diabetic macular edema

Clinical Features for Diabetic Macular Edema

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Drugs & Therapeutics for Diabetic Macular Edema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Macular Edema

Drug clinical trials:

Search ClinicalTrials for Diabetic Macular Edema

Search NIH Clinical Center for Diabetic Macular Edema

Search CenterWatch for Diabetic Macular Edema

Genetic Tests for Diabetic Macular Edema

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Anatomical Context for Diabetic Macular Edema

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32MalaCards
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MalaCards organs/tissues related to Diabetic Macular Edema:

32
Eye, Retina, Endothelial, Testes

Animal Models for Diabetic Macular Edema or affiliated genes

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36MGI
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Publications for Diabetic Macular Edema

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50PubMed
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Articles related to Diabetic Macular Edema:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Single injection of triamcinolone versus three repeated injections of bevacizumab for treatment of diabetic macular edema. (23334618)
2013
2
Structural changes in individual retinal layers in diabetic macular edema. (24073417)
2013
3
Current status in diabetic macular edema treatments. (24147200)
2013
4
Optical coherence tomography classification of diabetic cystoid macular edema. (24039393)
2013
5
Screening, prevention, and ambitious management of diabetic macular edema in patients with type 1 diabetes. (23959793)
2013
6
Fluocinolone acetonide and its potential in the treatment of chronic diabetic macular edema. (23503099)
2013
7
Fluocinolone acetonide intravitreal implant for the treatment of diabetic macular edema. (23737661)
2013
8
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: part 2. (23540955)
2013
9
Medical management for the prevention and treatment of diabetic macular edema. (23969020)
2013
10
Comparison of intravitreal triamcinolone acetonide with intravitreal bevacizumab for treatment of diabetic macular edema: a meta-analysis. (23405978)
2013
11
Functional and morphological changes in diabetic macular edema over the course of anti-vascular endothelial growth factor treatment. (23647578)
2013
12
External limiting membrane as a predictor of visual improvement in diabetic macular edema after pars plana vitrectomy. (22354371)
2012
13
Screening for diabetic retinopathy and diabetic macular edema in the United Kingdom. (22729994)
2012
14
Intravitreal tumor necrosis factor inhibitors in the treatment of refractory diabetic macular edema. (23047305)
2012
15
Repeatability of Spectralis OCT measurements of macular thickness and volume in diabetic macular edema. (23111610)
2012
16
Combined high-dose sub-tenon triamcinolone, intravitreal bevacizumab, and laser photocoagulation for refractory diabetic macular edema: a pilot study. (22366900)
2012
17
Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy. (22927737)
2012
18
Clinical applications of cost analysis of diabetic macular edema treatments. (23062655)
2012
19
Comparison of intravitreal bevacizumab, intravitreal triamcinolone acetonide, and macular grid augmentation in refractory diffuse diabetic macular edema: A prospective, randomized study. (23439853)
2012
20
Re: Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients. (22922851)
2012
21
Cystoid macular edema associated with oral antineoplastic agent s-1 in a patient with diabetic retinopathy. (22548042)
2012
22
Comparing central retinal thickness in diabetic macular edema measured by two different spectral-domain optical coherence tomography devices. (21887610)
2011
23
Rationale for the diabetic retinopathy clinical research network treatment protocol for center-involved diabetic macular edema. (22136692)
2011
24
Alpha-lipoic acid for the prevention of diabetic macular edema. (21811051)
2011
25
Diabetic macular edema: fundus autofluorescence and functional correlations. (20720226)
2011
26
Pattern electroretinogram changes after intravitreal bevacizumab injection for diabetic macular edema. (20140695)
2010
27
Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study. (20980427)
2010
28
Intravitreal Triamcinolone Acetonide Use in Diabetic Macular Edema: Illustrative Cases. (20337278)
2010
29
Diabetic macular edema. (19729104)
2009
30
Glitazone use associated with diabetic macular edema. (19181303)
2009
31
Intravitreal inserts of steroids to treat diabetic macular edema. (19199895)
2009
32
Comparison of optical coherence tomography in diabetic macular edema, with and without reading center manual grading from a clinical trials perspective. (18566462)
2009
33
Pars plana vitrectomy with internal limiting membrane peeling compared with intravitreal triamcinolone injection in the treatment of diabetic macular edema. (18849632)
2009
34
Diabetic macular edema. (19264220)
2009
35
Pegaptanib sodium for the treatment of proliferative diabetic retinopathy and diabetic macular edema. (19199896)
2009
36
Acute visual acuity loss following intravitreal bevacizumab for diabetic macular edema. (19205502)
2009
37
Posterior sub-Tenon injection of triamcinolone acetonide as pretreatment for focal laser photocoagulation in diabetic macular edema patients. (18773263)
2008
38
Topical nepafenac in the treatment of diabetic macular edema. (19668417)
2008
39
Pars plana vitrectomy with internal limiting membrane peeling for diabetic macular edema. (18327132)
2008
40
Update on treatments for diabetic macular edema. (18408491)
2008
41
Vitreous surgery for diabetic macular edema--its prognosis and correlation between preoperative systemic and ocular conditions and visual outcome. (18025629)
2007
42
Current treatment approaches in diabetic macular edema. (17380066)
2007
43
Deficit of somatostatin in the vitreous fluid of patients with diabetic macular edema. (17327350)
2007
44
Vitreous and aqueous concentrations of proangiogenic, antiangiogenic factors and other cytokines in diabetic retinopathy patients with macular edema: Implications for structural differences in macular profiles. (16324700)
2006
45
Nonproliferative diabetic retinopathy and macular edema progression after phacoemulsification: prospective study. (16931253)
2006
46
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema. (16406543)
2006
47
Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. (13129863)
2003
48
Resolution of diabetic cystoid macular edema associated with spontaneous vitreofoveal separation. (12504718)
2003
49
Prediction of macular edema exacerbation after phacoemulsification in patients with nonproliferative diabetic retinopathy. (12160804)
2002
50
Vitrectomy for diabetic macular edema: the role of posterior vitreous detachment and epimacular membrane. (11530050)
2001

Genetic Variations for Diabetic Macular Edema

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Expression for genes affiliated with Diabetic Macular Edema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Macular Edema

Search GEO for disease gene expression data for Diabetic Macular Edema.

Pathways for genes affiliated with Diabetic Macular Edema

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Sources:
49PharmGKB, 55SinoBiological, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Diabetic Macular Edema

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44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7SOD2
2gm-csf44 2811.6ICAM1
3bleomycin44 1111.6FGF2
4matrigel4410.6NOS3
5pge24410.3SST, VEGFA, REN
6diphenyleneiodonium4410.2SOD2, SERPINF1, DYT10
7perindopril44 49 1112.0REN, VEGFA, THBD, NOS3
8nadph44 2411.0PRKCB, SOD2, MGST1
9aminoguanidine44 28 1111.9NOS3, EPO, AKR1B1, SOD2
10olmesartan44 28 1111.9SERPINF1, REN, CCL2
11clonidine44 28 1111.9SST, FGF2, REN
12candesartan44 28 1111.8VEGFA, NOS3, CCL2, REN
13apocynin44 5910.8NOS3, VEGFA, DYT10, ICAM1
14dexamethasone44 49 28 1112.8SOD2, REN, FGF2, VEGFA, SERPINF1
15nitroglycerin44 1110.8SST, REN, NOS3, SOD2
16streptozotocin449.8SERPINF1, AKR1B1, SST, NOS3
178-isoprostane449.7NOS3, THBD, ICAM1, CCL2
18cyclophosphamide44 49 1111.7SST, THBD, NOS3, SOD2
19go 697644 5910.7PRKCB, ICAM1, CCL2, DYT10
20polymyxin b449.7ICAM1, DYT10, CCL2, THBD
21cyclosporin a44 28 5911.7ICAM1, AKR1B1, PRKCB, THBD, FGF2
22mannitol44 1110.7AKR1B1, ICAM1, SLC6A6
23creatinine449.7REN, EPO, PRKCB, AKR1B1, THBD
24cerivastatin44 49 28 1112.7REN, NOS3, ICAM1, CCL2
25aldose449.6PRKCB, AKR1B1, SOD2, SLC6A6
26atorvastatin44 49 28 11 2413.6ICAM1, VEGFA, THBD, NOS3, CCL2
27ang ii449.5VEGFA, CCL2, NOS3, REN, DYT10
28citrate449.5NOS3, AKR1B1, FGF2, SOD2, THBD
29curcumin449.5CCL2, SOD2, ICAM1, VEGFA, THBD, AKR1B1
30calcitriol44 59 11 2412.5FGF2, REN, EPO, PRKCB, SOD2, THBD
31simvastatin44 49 59 28 11 2414.5CCL2, VEGFA, NOS3, ICAM1, THBD
3215-deoxy-delta-12,14-prostaglandin j2449.4NOS3, FGF2, VEGFA, CCL2
33gf 109203x44 5910.4NOS3, PRKCB, SOD2, DYT10, VEGFA, FGF2
34fluvastatin44 49 28 1112.3NOS3, THBD, CCL2, ICAM1
35vitamin d449.2EPO, PRKCB, SOD2, THBD, NOS3, CCL2
36n acetylcysteine449.2AKR1B1, CCL2, ICAM1, SOD2, SERPINF1, DYT10
37ascorbic acid44 2410.2FGF2, ICAM1, THBD, SOD2, AKR1B1, EPO
38oxygen44 2410.1EPO, CCL2, ICAM1, AKR1B1, SERPINF1, PRKCB
39prostacyclin449.1REN, NOS3, CCL2, ICAM1, THBD, VEGFA
40sb 20358044 5910.1DYT10, VEGFA, FGF2, ICAM1, CCL2, NOS3
41h2o2448.9SERPINF1, THBD, FGF2, AKR1B1, MGST1, ICAM1
42phosphatidylcholine448.8DYT10, THBD, FGF2, PRKCB, CCL2
43ly294002448.7VEGFA, EPO, CCL2, SOD2, NOS3, ICAM1
44actinomycin d448.6THBD, FGF2, VEGFA, ICAM1, DYT10, SOD2
45arginine448.6MGST1, NOS3, CCL2, AKR1B1, SST, REN
46genistein44 28 59 2 11 2413.6VEGFA, AKR1B1, DYT10, SST, ICAM1, CCL2
47retinoic acid44 249.5PRKCB, DYT10, ICAM1, SERPINF1, NOS3, THBD
48nitric oxide44 11 2410.4SERPINF1, REN, SLC6A6, PRKCB, THBD, NOS3
49tyrosine447.8ICAM1, DYT10, PRKCB, MGST1, VEGFA, TYRO3
50vegf447.0REN, NOS3, THBD, FGF2, EPO, SST

GO Terms for genes affiliated with Diabetic Macular Edema

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16Gene Ontology
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Cellular components related to Diabetic Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8VEGFA, SST, EPO, REN, FGF2, SERPINF1
2extracellular spaceGO:0056158.0SERPINF1, CCL2, ICAM1, AKR1B1, VEGFA, SST

Biological processes related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1C21-steroid hormone biosynthetic processGO:00670010.1FGF2, AKR1B1
2negative regulation of platelet activationGO:01054410.1NOS3, THBD
3response to axon injuryGO:04867810.0SOD2, EPO, FGF2
4response to amino acid stimulusGO:0432009.9CCL2, ICAM1, SST
5regulation of blood pressureGO:0082179.9NOS3, REN, SOD2
6positive regulation of endothelial cell proliferationGO:0019389.9CCL2, VEGFA, FGF2
7response to heatGO:0094089.9NOS3, SST, CCL2
8negative regulation of calcium ion transportGO:0519269.8ICAM1, NOS3
9positive regulation of angiogenesisGO:0457669.8NOS3, FGF2, VEGFA, PRKCB
10lung developmentGO:0303249.8VEGFA, FGF2, NOS3
11cellular response to hypoxiaGO:0714569.8EPO, VEGFA, ICAM1
12response to hyperoxiaGO:0550939.7EPO, SOD2
13negative regulation of neuron apoptotic processGO:0435249.5TYRO3, SOD2, CCL2
14response to lipopolysaccharideGO:0324969.5SOD2, MGST1, EPO, REN
15response to drugGO:0424939.2CCL2, SOD2, ICAM1, MGST1, SST

Products for genes affiliated with Diabetic Macular Edema

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  • Antibodies
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Sources for Diabetic Macular Edema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet