MCID: DBT006
MIFTS: 46

Diabetic Macular Edema malady

Summaries for Diabetic Macular Edema

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Diabetic retinopathy, ([ˌrɛtnˈɑpəθi]) is retinopathy (damage to the retina) caused by... more...

MalaCards: Diabetic Macular Edema is related to proliferative diabetic retinopathy and blindness. An important gene associated with Diabetic Macular Edema is SERPINF1 (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1), and among its related pathways are VEGF Signaling Pathway and Angiogenesis. The compounds cycloheximide and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include retina and endothelial, and related mouse phenotypes are integument and nervous system.

Aliases & Classifications for Diabetic Macular Edema

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT
See all sources

Aliases & Descriptions:

diabetic macular edema 8 10 45 61


External Ids:

Disease Ontology8 DOID:9191
SNOMED-CT57 312912001
ICD9CM27 362.07

Related Diseases for Diabetic Macular Edema

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diabetic Macular Edema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative diabetic retinopathy30.7CCL2, ICAM1, VEGFA, SST, FGF2, SERPINF1
2blindness30.2AKR1B1, PRKCB, VEGFA, SERPINF1
3diabetic cataract10.6
4vitreous detachment10.6
5cystoid macular edema10.5
6central retinal vein occlusion10.3
7sleep disorder10.3
8central retinal artery occlusion10.2
9retinal ischemia10.2
10retinal microaneurysm10.2
11ischemic neuropathy10.2
12leukocoria10.2
13ischemic optic neuropathy10.2
14optic neuropathy, anterior ischemic10.2
15hypoxia10.2
16age related macular degeneration10.0VEGFA
17retinopathy of prematurity10.0VEGFA
18colorectal cancer10.0VEGFA
19endometrial carcinoma10.0VEGFA
20polyneuropathy10.0AKR1B1
21cervical cancer10.0DYT10
22diabetic polyneuropathy10.0AKR1B1
23cystic fibrosis10.0DYT10
24acute myocardial infarction10.0THBD
25von hippel-lindau disease10.0VEGFA
26lupus erythematosus10.0THBD
27stroke, ischemic10.0THBD
28senile cataract10.0SERPINF1
29dilated cardiomyopathy10.0DYT10
30sarcoma10.0SOD2
31hepatitis10.0SOD2
32eclampsia10.0THBD
33congestive heart failure10.0REN
34hepatitis c10.0SOD2
35dengue shock syndrome10.0THBD
36esophagitis10.0SOD2
37varicose veins10.0SST
38amyotrophic lateral sclerosis10.0SOD2
39thyroid cancer10.0SST
40inflammatory bowel disease10.0ICAM1
41meningioma10.0SST
42retinal detachment10.0SERPINF1, VEGFA
43dermatomyositis10.0ICAM1
44periodontal disease10.0ICAM1
45ovarian cancer10.0SERPINF1, VEGFA
46hyperthyroidism10.0SST
47retinal vein occlusion10.0VEGFA
48polymyositis10.0ICAM1
49leukostasis10.0ICAM1
50dermatitis10.0ICAM1

Graphical network of the top 20 diseases related to Diabetic Macular Edema:



Diseases related to diabetic macular edema

Clinical Features for Diabetic Macular Edema

Drugs & Therapeutics for Diabetic Macular Edema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Macular Edema

Drug clinical trials:

Search ClinicalTrials for Diabetic Macular Edema

Search NIH Clinical Center for Diabetic Macular Edema

Search CenterWatch for Diabetic Macular Edema

Genetic Tests for Diabetic Macular Edema

Anatomical Context for Diabetic Macular Edema

Sources:
33MalaCards
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MalaCards organs/tissues related to Diabetic Macular Edema:

33
Retina, Endothelial

Animal Models for Diabetic Macular Edema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Diabetic Macular Edema

Sources:
51PubMed
See all sources

Articles related to Diabetic Macular Edema:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
A novel color vision test for detection of diabetic macular edema. (24222302)
2014
2
Microaneurysm formation rate as a predictive marker for progression to clinically significant macular edema in nonproliferative diabetic retinopathy. (23792485)
2014
3
Factors affecting visual outcomes in patients with diabetic macular edema treated with ranibizumab. (24263379)
2013
4
Development of a Semi-Automatic Segmentation Method for Retinal OCT Images Tested in Patients with Diabetic Macular Edema. (24386127)
2013
5
Subtenon injection of natural leukocyte interferon I+-2a in diabetic macular edema: a case report. (24165224)
2013
6
The impact of metabolic parameters on clinical response to VEGF inhibitors for diabetic macular edema. (24374138)
2013
7
Evolving strategies in the management of diabetic macular edema: clinical trials and current management. (23419295)
2013
8
The relationship between foveal ischemia and spectral-domain optical coherence tomography findings in ischemic diabetic macular edema. (23329668)
2013
9
Ranibizumab for diabetic macular edema. Author reply. (23283201)
2013
10
Impact of intravitreal triamcinolone acetonide versus intravitreal bevacizumab on retrobulbar hemodynamic in patients with diabetic macular edema. (23742103)
2013
11
Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study. (22589436)
2012
12
Evaluation of a Novel, Non Contact, Automated Focal Laser with Integrated (NAVILAS) Fluorescein Angiography for Diabetic Macular Edema. (22346133)
2012
13
Intravitreal autologous plasmin as a therapeutic modality for diffuse diabetic macular edema. (23271887)
2012
14
Changes in ciliary body thickness in patients with diabetic macular edema after vitrectomy. (22466472)
2012
15
Corticosteroid use for diabetic macular edema: old fad or new trend? (22581206)
2012
16
Diabetic macular edema. (22517122)
2012
17
Relationship between fluorescein pooling and optical coherence tomographic reflectivity of cystoid spaces in diabetic macular edema. (22330965)
2012
18
Observational study of subclinical diabetic macular edema. (22441027)
2012
19
Diagnosing and monitoring diabetic macular edema: structural and functional tests. (22618128)
2012
20
Intravitreal injection of commercially available ketorolac tromethamine in eyes with diabetic macular edema refractory to laser photocoagulation. (21780926)
2011
21
Prophylactic intravitreal bevacizumab for diabetic macular edema (thickening) after cataract surgery: prospective randomized study. (20853269)
2011
22
Pars plana vitrectomy for diabetic macular edema. Internal limiting membrane delamination vs posterior hyaloid removal. A prospective randomized trial. (21243370)
2011
23
Diabetic macular edema. (21376246)
2011
24
Effect of intravitreal bevacizumab based on optical coherence tomography patterns of diabetic macular edema. (21822008)
2011
25
Ischemic maculopathy following intravitreal bevacizumab for refractory diabetic macular edema. (20852916)
2011
26
Intravitreal diclofenac versus intravitreal triamcinolone acetonide in the treatment of diabetic macular edema. (21765371)
2011
27
Combination of flavonoids with Centella asiatica and Melilotus for diabetic cystoid macular edema without macular thickening. (21314440)
2011
28
Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema. (20212197)
2010
29
Diabetic macular edema: correlations with available diabetes therapies--evidence across a qualitative review of published literature from MEDLINE and EMBASE. (20635822)
2010
30
A systematic correlation between morphology and functional alterations in diabetic macular edema. (20484587)
2010
31
Barely visible 10-millisecond pascal laser photocoagulation for diabetic macular edema: observations of clinical effect and burn localization. (20510687)
2010
32
Topical mecamylamine for diabetic macular edema. (20189159)
2010
33
Intravitreal bevacizumab for the treatment of refractory diabetic macular edema. (20507016)
2010
34
Pretreatment clinical variables associated with the response to intravitreal bevacizumab (Avastin) injection in patients with persistent diabetic macular edema. (23960890)
2010
35
Refractory diabetic macular edema. (22737347)
2010
36
Combined laser and intravitreal triamcinolone for proliferative diabetic retinopathy and macular edema: one-year results of a randomized clinical trial. (18929352)
2009
37
Intravitreal plasmin without associated vitrectomy as a treatment for refractory diabetic macular edema. (19650710)
2009
38
Assessment of serous macular detachment in eyes with diabetic macular edema by use of spectral-domain optical coherence tomography. (19547995)
2009
39
Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy. (19430805)
2009
40
Lanreotide Autogel for persistent diabetic macular edema. (18367285)
2008
41
Macular function by multifocal electroretinogram in diabetic macular edema after intravitreal triamcinolone acetonide injection. (18609482)
2008
42
ISIS-DME: a prospective, randomized, dose-escalation intravitreal steroid injection study for refractory diabetic macular edema. (18463518)
2008
43
Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema. (17628122)
2007
44
Cystoid and diabetic macular edema treated with nepafenac 0.1%. (18001248)
2007
45
Effect of posture on the diurnal variation in clinically significant diabetic macular edema. (17591904)
2007
46
Surgical removal of the internal limiting membrane in diabetic cystoid macular edema. (16603977)
2006
47
Combined intravitreal injection of triamcinolone acetonide and panretinal photocoagulation for concomitant diabetic macular edema and proliferative diabetic retinopathy. (15689801)
2005
48
Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema. (16186374)
2005
49
Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies. (12941734)
2003
50
Spontaneous evolution and photocoagulation of diabetic cystoid macular edema. (8045437)
1994

Genetic Variations for Diabetic Macular Edema

Expression for genes affiliated with Diabetic Macular Edema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Macular Edema

Search GEO for disease gene expression data for Diabetic Macular Edema.

Pathways for genes affiliated with Diabetic Macular Edema

Sources:
50PharmGKB, 56SinoBiological, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN, 30KEGG, 12EMD Millipore
See all sources

Compounds for genes affiliated with Diabetic Macular Edema

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7SOD2
2gm-csf45 2911.6ICAM1
3bleomycin45 1111.6FGF2
4matrigel4510.6NOS3
5pge24510.3SST, VEGFA, REN
6diphenyleneiodonium4510.2SOD2, SERPINF1, DYT10
7perindopril45 50 1112.0REN, VEGFA, THBD, NOS3
8nadph45 2411.0PRKCB, SOD2, MGST1
9aminoguanidine45 29 1111.9NOS3, EPO, AKR1B1, SOD2
10olmesartan45 29 1111.9SERPINF1, REN, CCL2
11clonidine45 29 1111.9SST, FGF2, REN
12candesartan45 29 1111.8VEGFA, NOS3, CCL2, REN
13apocynin45 6010.8NOS3, VEGFA, DYT10, ICAM1
14dexamethasone45 50 29 1112.8SOD2, REN, FGF2, VEGFA, SERPINF1
15nitroglycerin45 1110.8SST, REN, NOS3, SOD2
16streptozotocin459.8SERPINF1, AKR1B1, SST, NOS3
178-isoprostane459.7NOS3, THBD, ICAM1, CCL2
18cyclophosphamide45 50 1111.7SST, THBD, NOS3, SOD2
19go 697645 6010.7PRKCB, ICAM1, CCL2, DYT10
20polymyxin b459.7ICAM1, DYT10, CCL2, THBD
21cyclosporin a45 29 6011.7ICAM1, AKR1B1, PRKCB, THBD, FGF2
22mannitol45 1110.7AKR1B1, ICAM1, SLC6A6
23creatinine459.7REN, EPO, PRKCB, AKR1B1, THBD
24cerivastatin45 50 29 1112.7REN, NOS3, ICAM1, CCL2
25aldose459.6PRKCB, AKR1B1, SOD2, SLC6A6
26atorvastatin45 50 29 11 2413.6ICAM1, VEGFA, THBD, NOS3, CCL2
27ang ii459.5VEGFA, CCL2, NOS3, REN, DYT10
28citrate459.5NOS3, AKR1B1, FGF2, SOD2, THBD
29curcumin459.5CCL2, SOD2, ICAM1, VEGFA, THBD, AKR1B1
30calcitriol45 60 11 2412.5FGF2, REN, EPO, PRKCB, SOD2, THBD
31simvastatin45 50 60 29 11 2414.5CCL2, VEGFA, NOS3, ICAM1, THBD
3215-deoxy-delta-12,14-prostaglandin j2459.4NOS3, FGF2, VEGFA, CCL2
33gf 109203x45 6010.4NOS3, PRKCB, SOD2, DYT10, VEGFA, FGF2
34fluvastatin45 50 29 1112.3NOS3, THBD, CCL2, ICAM1
35vitamin d459.2EPO, PRKCB, SOD2, THBD, NOS3, CCL2
36n acetylcysteine459.2AKR1B1, CCL2, ICAM1, SOD2, SERPINF1, DYT10
37ascorbic acid45 2410.2FGF2, ICAM1, THBD, SOD2, AKR1B1, EPO
38oxygen45 2410.1EPO, CCL2, ICAM1, AKR1B1, SERPINF1, PRKCB
39prostacyclin459.1REN, NOS3, CCL2, ICAM1, THBD, VEGFA
40sb 20358045 6010.1DYT10, VEGFA, FGF2, ICAM1, CCL2, NOS3
41h2o2458.9SERPINF1, THBD, FGF2, AKR1B1, MGST1, ICAM1
42phosphatidylcholine458.8DYT10, THBD, FGF2, PRKCB, CCL2
43ly294002458.7VEGFA, EPO, CCL2, SOD2, NOS3, ICAM1
44actinomycin d458.6THBD, FGF2, VEGFA, ICAM1, DYT10, SOD2
45arginine458.6MGST1, NOS3, CCL2, AKR1B1, SST, REN
46genistein45 29 60 2 11 2413.6VEGFA, AKR1B1, DYT10, SST, ICAM1, CCL2
47retinoic acid45 249.5PRKCB, DYT10, ICAM1, SERPINF1, NOS3, THBD
48nitric oxide45 11 2410.4SERPINF1, REN, SLC6A6, PRKCB, THBD, NOS3
49tyrosine457.8ICAM1, DYT10, PRKCB, MGST1, VEGFA, TYRO3
50vegf457.0REN, NOS3, THBD, FGF2, EPO, SST

GO Terms for genes affiliated with Diabetic Macular Edema

Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Macular Edema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8CCL2, VEGFA, SST, EPO, REN, FGF2
2extracellular spaceGO:0056158.0CCL2, ICAM1, AKR1B1, VEGFA, SST, EPO

Biological processes related to Diabetic Macular Edema according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1C21-steroid hormone biosynthetic processGO:00670010.1FGF2, AKR1B1
2negative regulation of platelet activationGO:01054410.1NOS3, THBD
3response to axon injuryGO:04867810.0FGF2, EPO, SOD2
4response to amino acid stimulusGO:0432009.9SST, CCL2, ICAM1
5regulation of blood pressureGO:0082179.9SOD2, NOS3, REN
6positive regulation of endothelial cell proliferationGO:0019389.9FGF2, VEGFA, CCL2
7response to heatGO:0094089.9SST, NOS3, CCL2
8negative regulation of calcium ion transportGO:0519269.8ICAM1, NOS3
9positive regulation of angiogenesisGO:0457669.8VEGFA, NOS3, FGF2, PRKCB
10lung developmentGO:0303249.8VEGFA, NOS3, FGF2
11cellular response to hypoxiaGO:0714569.8ICAM1, VEGFA, EPO
12response to hyperoxiaGO:0550939.7EPO, SOD2
13negative regulation of neuron apoptotic processGO:0435249.5TYRO3, SOD2, CCL2
14response to lipopolysaccharideGO:0324969.5MGST1, SOD2, REN, EPO
15response to drugGO:0424939.2SOD2, CCL2, SST, ICAM1, MGST1

Products for genes affiliated with Diabetic Macular Edema

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Sources for Diabetic Macular Edema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet