MCID: DBT004
MIFTS: 52

Diabetic Polyneuropathy malady

Endocrine diseases, Neuronal diseases categories
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Summaries for Diabetic Polyneuropathy

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MalaCards based summary: Diabetic Polyneuropathy, also known as polyneuropathy in diabetes, is related to polyneuropathy and neuropathy. An important gene associated with Diabetic Polyneuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Development HGF signaling pathway. The compounds valproate and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include testes, spinal cord and skin, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Aliases & Classifications for Diabetic Polyneuropathy

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Diabetic Polyneuropathy, Aliases & Descriptions:

Name: Diabetic Polyneuropathy 8 44
Polyneuropathy in Diabetes 8 62
 
Diabetes Mellitus with Polyneuropathy 8
Diabetic Polyneuropathies 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Neuronal diseases


Related Diseases for Diabetic Polyneuropathy

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Graphical network of the top 20 diseases related to Diabetic Polyneuropathy:



Diseases related to diabetic polyneuropathy

Symptoms for Diabetic Polyneuropathy

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Drugs & Therapeutics for Diabetic Polyneuropathy

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Drug clinical trials:

Search ClinicalTrials for Diabetic Polyneuropathy

Search NIH Clinical Center for Diabetic Polyneuropathy

Genetic Tests for Diabetic Polyneuropathy

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Anatomical Context for Diabetic Polyneuropathy

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MalaCards organs/tissues related to Diabetic Polyneuropathy:

32
Testes, Spinal cord, Skin, Pancreas, Bone, Endothelial, Brain, Heart, Kidney, Thalamus

Animal Models for Diabetic Polyneuropathy or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Polyneuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9NTF3, AKR1B1, NGF
2MP:00053767.8NGF, SOD3, AKR1B1, NTF3
3MP:00107687.4NTF3, AKR1B1, SOD3, NGF, C10orf2

Publications for Diabetic Polyneuropathy

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Articles related to Diabetic Polyneuropathy:

(show top 50)    (show all 279)
idTitleAuthorsYear
1
Mobile biofeedback of heart rate variability in patients with diabetic polyneuropathy: a preliminary study. (24438496)
2014
2
Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy. (24713310)
2014
3
Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. (24319678)
2013
4
Whither pathogenetic treatments for diabetic polyneuropathy? (23381942)
2013
5
Influence of a specific, biorhythmically defined physical stimulus on deficient vasomotion in small-caliber arterioles in the subcutis in patients with diabetic polyneuropathy. (24021603)
2013
6
Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. (23877983)
2013
7
Thermal threshold: research study on small fiber dysfunction in distal diabetic polyneuropathy. (22401337)
2012
8
Clinical and electrophysiological signs of diabetic polyneuropathy -- effect of glycemia and duration of diabetes mellitus. (22263377)
2011
9
Letter: diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients (diabetes metab j 2011;35:390-6). (22111049)
2011
10
Power spectral analyses of index finger skin blood perfusion in carpal tunnel syndrome and diabetic polyneuropathy. (21716676)
2011
11
Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. (21941444)
2011
12
Efficacy and safety of antioxidant treatment with I+-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. (21775755)
2011
13
Non-pharmacological correction of impaired microcirculation in children with diabetic polyneuropathy. (20151328)
2010
14
A Comparative study of examination scores and quantitative sensory testing in diagnosis of diabetic polyneuropathy. (20431806)
2010
15
A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. (19738078)
2009
16
The beneficial effects of C-Peptide on diabetic polyneuropathy. (20039008)
2009
17
Diabetic polyneuropathy may increase the handicap related to vestibular disease. (19427968)
2009
18
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
19
Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients. (18054108)
2008
20
Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy. (17478005)
2007
21
Strength-duration properties in diabetic polyneuropathy. (17408800)
2007
22
Association of polymorphous markers Pro72Arg and C(-594)CC OF TP53 gene with diabetic polyneuropathy in patients with type 1 diabetes mellitus living in Moscow]. (18318116)
2007
23
Comparison of the utility of sympathetic skin response and current perception threshold examinations with conventional examinations for the early electrophysiological diagnosis of diabetic polyneuropathy. (17191732)
2006
24
Two-stage community-based screening model for estimating prevalence of diabetic polyneuropathy (KCIS no. 6). (15855798)
2005
25
The value of the Rydel-Seiffer tuning fork as a predictor of diabetic polyneuropathy compared with a neurothesiometer. (15154940)
2004
26
Effectiveness, tolerability, and impact on quality of life of the 5% lidocaine patch in diabetic polyneuropathy. (15210530)
2004
27
Treatment of diabetic polyneuropathy with alpha-lipoic acid is evidence based. (15529620)
2004
28
Animal models of human diabetic polyneuropathy. (12684353)
2003
29
Clinical diagnosis of diabetic polyneuropathy with the diabetic neuropathy symptom and diabetic neuropathy examination scores. (12610024)
2003
30
New insights into diabetic polyneuropathy. (12966130)
2003
31
Sodium valproate in painful diabetic polyneuropathy. (14616298)
2003
32
Hyperesthesia: an early manifestation of diabetic polyneuropathy. (12521185)
2002
33
Carpal tunnel syndrome in patients with diabetic polyneuropathy. (11874948)
2002
34
Nerve growth factor (NGF) in treatment of diabetic polyneuropathy. One hope less?]. (11433707)
2001
35
The role of glycation in the pathogenesis of diabetic polyneuropathy. (11724915)
2001
36
Status of current clinical trials in diabetic polyneuropathy. (11513337)
2001
37
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
38
Methods for assessing diabetic polyneuropathy: validity and reproducibility of the measurement of sensory symptom severity and nerve function tests. (10670907)
2000
39
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. (10595592)
1999
40
Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. (10227655)
1999
41
F-wave-duration in diabetic polyneuropathy. (9466603)
1998
42
Subacute uremic and diabetic polyneuropathy. (8995584)
1997
43
Motor nerve refractory period distribution assessed by two techniques in diabetic polyneuropathy. (7521291)
1994
44
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
45
Structural functional interactions in the natural history of diabetic polyneuropathy: a key to the understanding of neuropathic pain? (8334853)
1993
46
Diagnosis and therapy of diabetic polyneuropathy]. (8517070)
1993
47
Clinical examination versus neurophysiological examination in the diagnosis of diabetic polyneuropathy. (1395463)
1992
48
Effects of pancreatic transplantation on diabetic polyneuropathy. (1989323)
1991
49
Variability of three standard neurophysiological techniques in established symptomatic diabetic polyneuropathy. (2635095)
1989
50
Vasodilation induced by transcutaneous nerve stimulation in peripheral ischemia (Raynaud's phenomenon and diabetic polyneuropathy). (6982164)
1982

Variations for Diabetic Polyneuropathy

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Expression for genes affiliated with Diabetic Polyneuropathy

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Expression patterns in normal tissues for genes affiliated with Diabetic Polyneuropathy

Search GEO for disease gene expression data for Diabetic Polyneuropathy.

Pathways for genes affiliated with Diabetic Polyneuropathy

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Pathways related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.3NTF3, NGF
2
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3NTF3, NGF
3
Show member pathways
9.3NGF, NTF3
49.3NTF3, NGF
5
Show member pathways
9.3NTF3, NGF
6
Show member pathways
9.3NTF3, NGF

Compounds for genes affiliated with Diabetic Polyneuropathy

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Compounds related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1valproate449.8NTF3, AKR1B1
2streptozotocin449.8AKR1B1, NTF3
3alpha lipoic acid449.7AKR1B1, NGF
4capsaicin44 2810.7NGF, AKR1B1
5k252a449.7NTF3, NGF
6levodopa44 1110.7NGF, AKR1B1
7inositol449.7NTF3, AKR1B1
8desipramine44 50 1111.7NTF3, NGF
9ganglioside449.6NTF3, NGF
10anisomycin44 1110.6NTF3, NGF
11dihydrotestosterone44 28 24 1112.6AKR1B1, NGF
12cocaine44 1110.6NGF, NTF3
13carbachol44 28 1111.6NGF, NTF3
14quercetin44 61 24 1112.5AKR1B1, NGF
15choline44 24 1111.5NGF, NTF3
16nicotine44 28 50 1112.3NTF3, NGF
17chloramphenicol44 2 50 1112.3NTF3, NGF
18glycerol44 24 1111.3AKR1B1, NGF
19nmda44 2810.3NTF3, AKR1B1, NGF
20norepinephrine44 24 1111.3NGF, AKR1B1, NTF3
21actinomycin d449.2NGF, AKR1B1, NTF3
22genistein44 28 61 2 24 1114.2NGF, AKR1B1, NTF3
23heparan sulfate44 2410.2SOD3, NTF3
24cycloheximide449.2NTF3, AKR1B1, NGF
25aspirin44 50 28 2412.1AKR1B1, NGF
26oxygen44 249.9NTF3, AKR1B1, SOD3
27acetylcholine44 50 28 24 1112.9NTF3, SOD3, NGF
28alanine448.8AKR1B1, SOD3, NGF
29adenylate448.5NTF3, AKR1B1, SOD3, NGF
30vegf448.4NGF, SOD3, AKR1B1, NTF3
31arginine448.4NGF, SOD3, AKR1B1, NTF3
32cysteine448.4NGF, SOD3, AKR1B1, NTF3

GO Terms for genes affiliated with Diabetic Polyneuropathy

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Cellular components related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057968.7SOD3, NGF
2extracellular spaceGO:0056158.6AKR1B1, SOD3, NGF

Biological processes related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3NTF3, NGF
2peripheral nervous system developmentGO:0074229.2NTF3, NGF
3transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.0NTF3, NGF

Molecular functions related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3NTF3, NGF

Products for genes affiliated with Diabetic Polyneuropathy

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Sources for Diabetic Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet