MCID: DBT004
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Diabetic Polyneuropathy malady

Neuronal diseases category

Summaries for Diabetic Polyneuropathy

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MalaCards: Diabetic Polyneuropathy, also known as diabetes mellitus with polyneuropathy, is related to polyneuropathy and diabetic neuropathy. An important gene associated with Diabetic Polyneuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds tetrahydrobiopterin and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and pancreas, and related mouse phenotypes are adipose tissue and renal/urinary system.

Aliases & Classifications for Diabetic Polyneuropathy

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

diabetic polyneuropathy 8 44
diabetes mellitus with polyneuropathy 8
polyneuropathy in diabetes 8
diabetic polyneuropathies 60


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Disease Ontology8 DOID:12785
ICD9CM27 357.2
MeSH34 D003929
ICD1025 G63.2

Related Diseases for Diabetic Polyneuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy31.7CNTF, POLG, AKR1B1
2diabetic neuropathy30.7AKR1B1, CNTF, NTF3, NGF, SOD3
3neuropathy30.7NTF3, AKR1B1, SOD2, C10orf2, POLG, NGF
4diabetes mellitus30.6PARP1, NOS3, THBD, GPX1, NGF, AKR1B1
5diabetic autonomic neuropathy30.3NGF, AKR1B1
6autonomic neuropathy30.3AKR1B1, NGF, NTF3
7hyperglycemia30.1AKR1B1, GPX1, NOS3, CAT, NOS2, SOD2
8ischemia30.1CAT, SOD2, AKR1B1, NTF3, CNTF, GPX1
9neuroblastoma29.9NGF
10pancreatitis29.9SOD2
11type 2 diabetes mellitus29.9NGF, AKR1B1, NOS3, THBD, CAT
12obesity29.9AKR1B1, SOD2, CNTF, NOS3, NOS1, GSTM1
13type 1 diabetes mellitus10.4
14carpal tunnel syndrome10.3
15chronic polyneuropathy10.3
16demyelinating polyneuropathy10.2
17peripheral neuropathy10.2
18peritonitis10.0LIF
19cystitis10.0NGF
20eclampsia10.0THBD
21dilated cardiomyopathy10.0SLC25A4
22cerebrovascular disease10.0SOD3
23lupus erythematosus10.0THBD
24nephritis10.0LIF
25ophthalmoplegia10.0SLC25A4
26atopic dermatitis10.0NGF
27vasculitis10.0THBD
28hypogonadism10.0POLG
29choriocarcinoma10.0LIF
30meningioma10.0GSTT1
31pituitary tumors10.0LIF
32liver cirrhosis10.0NOS3
33migraine10.0GSTM1
34vitiligo10.0CAT
35lupus nephritis10.0THBD
36cystic fibrosis10.0GSTM1
37meningitis10.0CAT
38spermatic cord torsion10.0CAT
39pneumoconiosis10.0CAT
40graves' disease10.0NOS3
41sickle cell disease10.0NOS3
42glaucoma10.0CNTF, AKR1B1
43primary open angle glaucoma10.0GSTM1
44hepatopulmonary syndrome10.0NOS3
45blindness10.0AKR1B1, CNTF
46schistosomiasis10.0GSTM1
47mitochondrial disorders10.0POLG
48hypoglycemia10.0AKR1B1, POLG
49dermatitis10.0LIF, NTF3
50achalasia10.0NOS1

Graphical network of the top 20 diseases related to Diabetic Polyneuropathy:



Diseases related to diabetic polyneuropathy

Clinical Features for Diabetic Polyneuropathy

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Drugs & Therapeutics for Diabetic Polyneuropathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Diabetic Polyneuropathy

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Anatomical Context for Diabetic Polyneuropathy

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32MalaCards
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MalaCards organs/tissues related to Diabetic Polyneuropathy:

32
Testes, Skin, Pancreas, Endothelial, Bone, Spinal cord, Kidney, Heart, Brain, Thalamus

Animal Models for Diabetic Polyneuropathy or affiliated genes

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36MGI
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Publications for Diabetic Polyneuropathy

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50PubMed
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Articles related to Diabetic Polyneuropathy:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Case scenario: residual curarization in diabetic polyneuropathy. (24051390)
2014
2
Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. (23877983)
2013
3
The impact of common variation in the definition of diabetic sensorimotor polyneuropathy on the validity of corneal in vivo confocal microscopy in patients with type 1 diabetes: a brief report. (23266297)
2013
4
The importance of L-arginine metabolism modulation in diabetic patients with distal symmetric polyneuropathy. (23103148)
2013
5
"Unequivocally Abnormal" vs "Usual" Signs and Symptoms for Proficient Diagnosis of Diabetic Polyneuropathy: Cl vs N Phys Trial. (22986424)
2012
6
Combined nerve conduction index in diabetic polyneuropathy. (22618785)
2012
7
Postchallenge hyperglycemia is positively associated with diabetic polyneuropathy: the KORA F4 study. (22751964)
2012
8
The medial plantar and medial peroneal cutaneous nerve conduction studies for diabetic polyneuropathy. (21720897)
2011
9
Skin intrinsic fluorescence correlates with autonomic and distal symmetrical polyneuropathy in individuals with type 1 diabetes. (21307380)
2011
10
A controlled study of medial arterial calcification of legs: implications for diabetic polyneuropathy. (21987542)
2011
11
Non-pharmacological correction of impaired microcirculation in children with diabetic polyneuropathy. (20151328)
2010
12
Comparison of nerve conduction studies with diabetic neuropathy symptom score and diabetic neuropathy examination score in type-2 diabetics for detection of sensorimotor polyneuropathy. (19750851)
2009
13
A new pathogenetic treatment for symptomatic diabetic polyneuropathy? (19954683)
2009
14
Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients. (18054108)
2008
15
Muscle fiber conduction abnormalities in early diabetic polyneuropathy. (18387339)
2008
16
Strength-duration properties in diabetic polyneuropathy. (17408800)
2007
17
The effect of hyperventilation on strength-duration properties in diabetic polyneuropathy. (17095293)
2007
18
Treatment of diabetic polyneuropathy: Update 2006. (17151306)
2006
19
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. (17065669)
2006
20
Foot temperature in diabetic polyneuropathy: innocent bystander or unrecognized accomplice? (15717867)
2005
21
Validation of a novel screening device (NeuroQuick) for quantitative assessment of small nerve fiber dysfunction as an early feature of diabetic polyneuropathy. (15855584)
2005
22
Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy. (15333481)
2004
23
Diabetic polyneuropathy. Axonal or demyelinating? (11851006)
2002
24
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
25
Limits of the sympathetic skin response in patients with diabetic polyneuropathy. (10951447)
2000
26
Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. (10227655)
1999
27
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. (10480774)
1999
28
Nerve conduction study in diabetic polyneuropathy: multicenter analysis on intertrial variability. (10689505)
1999
29
Clinical significance of the F wave area in diabetic polyneuropathy. (10207678)
1999
30
F-wave-duration in diabetic polyneuropathy. (9466603)
1998
31
The assessment of diabetic polyneuropathy in daily clinical practice: reproducibility and validity of Semmes Weinstein monofilaments examination and clinical neurological examination. (8995595)
1997
32
Diabetic polyneuropathy. (9100676)
1997
33
Reproducibility of different nerve conduction velocity measurements in healthy test subjects and patients suffering from diabetic polyneuropathy. (9313997)
1997
34
Treatment of diabetic polyneuropathy with the neurotrophic peptide ORG 2766. (8936356)
1996
35
Solitary eccrine syringofibroadenoma (or eccrine syringofibroadenomatous hyperplasia?) and diabetic polyneuropathy. (8864629)
1996
36
Motor nerve refractory period distribution assessed by two techniques in diabetic polyneuropathy. (7521291)
1994
37
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
38
Structural functional interactions in the natural history of diabetic polyneuropathy: a key to the understanding of neuropathic pain? (8334853)
1993
39
Diagnosis and therapy of diabetic polyneuropathy]. (8517070)
1993
40
Acute and remitting painful diabetic polyneuropathy: a comparison of peripheral nerve fibre pathology. (1594258)
1992
41
Graded assessment and classification of impaired temperature sensibility in patients with diabetic polyneuropathy. (1880516)
1991
42
Association of painful and painless diabetic polyneuropathy with different patterns of nerve fiber degeneration and regeneration. (2373262)
1990
43
Diagnosis of diabetic polyneuropathy. Correlation between clinical and instrumental findings and assessment of simple diagnostic criteria. (3225169)
1988
44
Deleterious effect of the carpal tunnel on nerve conduction in diabetic polyneuropathy. (3248552)
1988
45
Chronic and remitting painful diabetic polyneuropathy. Correlations with clinical features and subsequent changes in neurophysiology. (3338378)
1988
46
Diabetic polyneuropathy and renal transplantation. (3313867)
1987
47
Clinical and neuropathological criteria for the diagnosis and staging of diabetic polyneuropathy. (4075076)
1985
48
Studies of diabetic polyneuropathy using conduction velocity distribution (DCV) analysis. (6682521)
1983
49
Microneurographic findings in diabetic polyneuropathy with special reference to sympathetic nerve activity. (7173519)
1982
50
Distal slowing of motor nerve conduction velocity in diabetic polyneuropathy. (479916)
1979

Genetic Variations for Diabetic Polyneuropathy

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Expression for genes affiliated with Diabetic Polyneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Polyneuropathy

Search GEO for disease gene expression data for Diabetic Polyneuropathy.

Pathways for genes affiliated with Diabetic Polyneuropathy

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49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CAT, GPX1
210.0GSTT1, GSTM1
310.0GSTT1, GSTM1
49.8CAT, SOD3, GPX1
5
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9.8CNTF, LIF, SOD2
6
Naphthalene metabolism
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9.8AKR1B1, GSTM1, GSTT1
79.8SOD2, SOD3, CAT
8
Glutathione metabolism
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9.8GPX1, GSTM1, GSTT1
99.8NOS3, THBD, LIF
10
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9.7NOS1, GPX1, CAT
119.6CAT, SOD3, SOD2, GPX1
129.6CAT, SOD3, SOD2, GPX1
139.6NOS2, SOD2, CAT
149.5NOS3, NOS2, NOS1
15
NO-dependent CFTR activation (normal and CF)
9.5NOS3, NOS2, NOS1
169.5NOS3, NOS2, NOS1
17
Hide members
9.5NOS1, NOS2, NOS3
18
CFTR folding and maturation (norm and CF)
9.5NOS1, NOS2, NOS3
19
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9.3NOS2, NOS3, GPX1, CAT
209.3SLC25A4, NOS3, NOS2, NOS1
21
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9.3THBD, NOS3, NOS2, NOS1
22
Hide members
8.6GPX1, SLC25A4, NOS3, NOS2, NOS1, GSTM1

Compounds for genes affiliated with Diabetic Polyneuropathy

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 243)
idCompoundScoreTop Affiliating Genes
1tetrahydrobiopterin44 11 2412.1NOS3, NOS1, AKR1B1
2cycloheximide4410.0PARP1, SOD2, CAT
3nadph44 2411.0SOD3, SOD2, GPX1, NOS1
4indomethacin44 59 28 1112.9NOS1, NOS3, NGF, AKR1B1
5alpha tocopherol449.8GPX1, GSTM1, LIF, SOD2
6norepinephrine44 11 2411.8NTF3, BMP6, LIF, CNTF
78-oxo-dg449.6SOD2, GSTT1, CAT, GSTM1, GPX1
8gamma-glutamylcysteine44 11 2411.6GPX1, GSTM1, CAT, SOD3, SOD2
9superoxide44 2410.5SOD3, NOS1, NOS3, CNTF, NTF3, LIF
10ptio449.5NOS2, NOS3, NOS1, CAT
11onoo449.5SOD2, NOS3, NOS1, NOS2
12aminoguanidine44 28 1111.5SOD2, AKR1B1, NOS3, NOS2, NOS1
13cyclosporin a44 28 5911.5NOS1, AKR1B1, THBD, NGF, LIF, SLC25A4
14pdtc449.4CAT, NGF, NOS2, NOS1, SOD2
15vitamin-e449.4GSTT1, NTF3, CAT, CNTF, THBD, GPX1
16manganese superoxide449.4GSTM1, GPX1, SOD2, CAT, SOD3, GSTT1
17malondialdehyde449.4GSTT1, GSTM1, GPX1, SOD2, SOD3, CAT
18h2o2449.3CAT, AKR1B1, LIF, CNTF, PARP1, THBD
19selenium44 2410.3LIF, GPX1, SOD2, CAT, SOD3
20choline44 11 2411.1NOS1, NOS3, NGF, NTF3, LIF, CNTF
21silymarin449.1NOS2, CAT, BMP6, AKR1B1, PARP1
22s-nitroso-n-acetylpenicillamine449.1NOS3, NOS1, NOS2, AKR1B1, CAT, PARP1
23folate449.1GSTT1, GSTM1, NOS1, NOS3, SOD2, SOD3
24vitamin d449.1GSTM1, THBD, NGF, BMP6, SOD2, SOD3
25carbachol44 28 1111.0NOS1, NTF3, NGF, LIF, BMP6, NOS3
264-hydroxynonenal44 2410.0PARP1, NOS2, GPX1, CAT, GSTM1, SOD2
27dopamine44 28 11 2412.0NOS1, BMP6, GSTM1, SOD2, CNTF, LIF
28betacarotene448.9SOD2, LIF, THBD, CAT, GSTM1
29oxygen44 249.9NOS1, NOS2, SOD3, AKR1B1, POLG, SLC25A4
30creatinine448.9NGF, BMP6, GSTT1, GSTM1, AKR1B1, SLC25A4
31n acetylcysteine448.9PARP1, NOS2, CNTF, CAT, SOD3, GPX1
32adenylate448.9SLC25A4, SOD3, AKR1B1, NTF3, POLG, CNTF
33curcumin448.8CAT, SOD2, AKR1B1, NOS2, PARP1, THBD
34sodium nitroprusside448.8NOS3, NOS1, CAT, SOD2, BMP6, NOS2
35peroxynitrite448.7NOS1, CAT, SOD3, SOD2, GPX1, NOS3
36lactate448.7BMP6, AKR1B1, LIF, SOD2, CAT, THBD
37ly294002448.6SOD2, BMP6, CNTF, NGF, NOS2, PARP1
38cisplatin44 49 59 1111.6LIF, GSTT1, GSTM1, PARP1, SOD2, BMP6
39alanine448.5NGF, GPX1, THBD, SOD2, CNTF, POLG
40sb 20358044 599.4CAT, BMP6, LIF, NGF, NOS3, NOS2
41genistein44 28 59 2 11 2413.4NTF3, LIF, AKR1B1, NOS2, NOS1, NOS3
42acetylcholine44 49 28 11 2412.3SOD3, BMP6, NTF3, NGF, LIF, SOD2
43actinomycin d448.2NGF, LIF, AKR1B1, SOD2, NTF3, CNTF
44retinoic acid44 249.2NGF, NOS1, NOS3, SLC25A4, THBD, CNTF
45cysteine448.1NTF3, SOD3, PARP1, NOS1, THBD, GPX1
46ascorbic acid44 248.9GSTM1, NOS1, NOS2, NOS3, THBD, CNTF
47arginine447.9NTF3, NGF, GSTM1, THBD, NOS3, NOS1
48nitric oxide44 11 249.8SOD3, GPX1, THBD, NOS1, NOS2, NOS3
49doxorubicin44 49 119.8GPX1, PARP1, GSTM1, NOS1, NOS2, NOS3
50vegf447.6NOS3, THBD, NGF, CNTF, NTF3, LIF

GO Terms for genes affiliated with Diabetic Polyneuropathy

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16Gene Ontology
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Cellular components related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial nucleoidGO:0426459.7POLG, SOD2, C10orf2
2extracellular spaceGO:0056159.1SOD3, BMP6, AKR1B1, LIF, CNTF, NGF
3cytosolGO:0058297.9NOS1, NOS2, NOS3, GPX1, AKR1B1, SOD3

Biological processes related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1mitochondrial DNA replicationGO:00626410.3POLG, C10orf2
2muscle organ morphogenesisGO:04864410.3LIF, CNTF
3response to selenium ionGO:01026910.2GPX1, SOD2
4negative regulation of platelet activationGO:01054410.1THBD, NOS3
5negative regulation of hydrolase activityGO:05134610.1NOS1, NOS3
6negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.1NOS3, GPX1
7neuron developmentGO:04866610.1CNTF, LIF, SOD2
8removal of superoxide radicalsGO:01943010.1SOD3, SOD2
9peptidyl-cysteine S-nitrosylationGO:01811910.1NOS1, NOS2
10negative regulation of neuron apoptotic processGO:04352410.0SOD2, NTF3, CNTF, NGF
11negative regulation of potassium ion transportGO:0432679.9NOS3, NOS1
12response to hyperoxiaGO:0550939.9SOD2, CAT
13UV protectionGO:0096509.9CAT, GPX1
14glutathione metabolic processGO:0067499.9GSTT1, GSTM1, GPX1, SOD2
15positive regulation of guanylate cyclase activityGO:0312849.9NOS1, NOS2, NOS3
16arginine catabolic processGO:0065279.9NOS3, NOS2, NOS1
17nitric oxide biosynthetic processGO:0068099.8NOS3, NOS2, NOS1
18nitric oxide mediated signal transductionGO:0072639.8NOS1, NOS2, NOS3
19positive regulation of vasodilationGO:0459099.8NOS3, NOS2, NOS1
20negative regulation of blood pressureGO:0457769.8NOS3, NOS2, NOS1
21interaction with hostGO:0517019.8NOS3, NOS2, NOS1
22phagosome maturationGO:0903829.8NOS1, NOS2, NOS3
23purine nucleotide catabolic processGO:0061959.7CAT, GPX1
24response to hypoxiaGO:0016669.4NOS1, NOS2, SOD2, SOD3, CAT
25small molecule metabolic processGO:0442819.0CAT, AKR1B1, GPX1, SLC25A4, NOS3, GSTM1

Molecular functions related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1superoxide dismutase activityGO:00478410.1SOD3, SOD2
2nitric-oxide synthase activityGO:0045179.8NOS1, NOS2, NOS3
3arginine bindingGO:0346189.7NOS3, NOS2, NOS1
4tetrahydrobiopterin bindingGO:0346179.7NOS3, NOS2, NOS1
5NADPH-hemoprotein reductase activityGO:0039589.7NOS1, NOS2, NOS3
6FMN bindingGO:0101819.6NOS1, NOS2, NOS3
7cadmium ion bindingGO:0468709.6NOS3, NOS1
8growth factor activityGO:0080839.5BMP6, LIF, NTF3, CNTF, NGF
9receptor bindingGO:0051029.4NOS2, NTF3, LIF, CAT
10NADP bindingGO:0506619.4CAT, NOS3, NOS2, NOS1
11flavin adenine dinucleotide bindingGO:0506609.4NOS1, NOS2, NOS3
12heme bindingGO:0200379.3CAT, NOS3, NOS2, NOS1

Products for genes affiliated with Diabetic Polyneuropathy

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Sources for Diabetic Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet