MCID: DBT004
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Diabetic Polyneuropathy malady

Neuronal diseases category

Summaries for Diabetic Polyneuropathy

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MalaCards: Diabetic Polyneuropathy, also known as diabetes mellitus with polyneuropathy, is related to polyneuropathy and diabetic neuropathy. An important gene associated with Diabetic Polyneuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds tetrahydrobiopterin and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and pancreas, and related mouse phenotypes are adipose tissue and renal/urinary system.

Aliases & Classifications for Diabetic Polyneuropathy

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

diabetic polyneuropathy 8 44
diabetes mellitus with polyneuropathy 8
polyneuropathy in diabetes 8
diabetic polyneuropathies 60


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Disease Ontology8 DOID:12785
ICD9CM27 357.2
MeSH34 D003929
ICD1025 G63.2

Related Diseases for Diabetic Polyneuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy31.7CNTF, POLG, AKR1B1
2diabetic neuropathy30.7AKR1B1, CNTF, NTF3, NGF, SOD3
3neuropathy30.7NTF3, AKR1B1, SOD2, C10orf2, POLG, NGF
4diabetes mellitus30.6PARP1, NOS3, THBD, GPX1, NGF, AKR1B1
5diabetic autonomic neuropathy30.3NGF, AKR1B1
6autonomic neuropathy30.3AKR1B1, NGF, NTF3
7hyperglycemia30.1AKR1B1, GPX1, NOS3, CAT, NOS2, SOD2
8ischemia30.1CAT, SOD2, AKR1B1, NTF3, CNTF, GPX1
9neuroblastoma29.9NGF
10pancreatitis29.9SOD2
11type 2 diabetes mellitus29.9NGF, AKR1B1, NOS3, THBD, CAT
12obesity29.9AKR1B1, SOD2, CNTF, NOS3, NOS1, GSTM1
13type 1 diabetes mellitus10.4
14carpal tunnel syndrome10.3
15chronic polyneuropathy10.3
16demyelinating polyneuropathy10.2
17peripheral neuropathy10.2
18peritonitis10.0LIF
19cystitis10.0NGF
20eclampsia10.0THBD
21dilated cardiomyopathy10.0SLC25A4
22cerebrovascular disease10.0SOD3
23lupus erythematosus10.0THBD
24nephritis10.0LIF
25ophthalmoplegia10.0SLC25A4
26atopic dermatitis10.0NGF
27vasculitis10.0THBD
28hypogonadism10.0POLG
29choriocarcinoma10.0LIF
30meningioma10.0GSTT1
31pituitary tumors10.0LIF
32liver cirrhosis10.0NOS3
33migraine10.0GSTM1
34vitiligo10.0CAT
35lupus nephritis10.0THBD
36cystic fibrosis10.0GSTM1
37meningitis10.0CAT
38spermatic cord torsion10.0CAT
39pneumoconiosis10.0CAT
40graves' disease10.0NOS3
41sickle cell disease10.0NOS3
42glaucoma10.0CNTF, AKR1B1
43primary open angle glaucoma10.0GSTM1
44hepatopulmonary syndrome10.0NOS3
45blindness10.0AKR1B1, CNTF
46schistosomiasis10.0GSTM1
47mitochondrial disorders10.0POLG
48hypoglycemia10.0AKR1B1, POLG
49dermatitis10.0LIF, NTF3
50achalasia10.0NOS1

Graphical network of the top 20 diseases related to Diabetic Polyneuropathy:



Diseases related to diabetic polyneuropathy

Clinical Features for Diabetic Polyneuropathy

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Drugs & Therapeutics for Diabetic Polyneuropathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Diabetic Polyneuropathy

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Anatomical Context for Diabetic Polyneuropathy

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32MalaCards
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MalaCards organs/tissues related to Diabetic Polyneuropathy:

32
Testes, Skin, Pancreas, Endothelial, Bone, Spinal cord, Kidney, Heart, Brain, Thalamus

Animal Models for Diabetic Polyneuropathy or affiliated genes

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36MGI
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Publications for Diabetic Polyneuropathy

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50PubMed
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Articles related to Diabetic Polyneuropathy:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
Motor nerve impairment in diabetic patients with symmetrical distal sensory polyneuropathy: a single nerve fiber conduction velocity study. (23588824)
2014
2
Whither pathogenetic treatments for diabetic polyneuropathy? (23381942)
2013
3
Strength Training Affects Lower Extremity Gait Kinematics, Not Kinetics, in People With Diabetic Polyneuropathy. (24042012)
2013
4
Evaluation of low level laser therapy in reducing diabetic polyneuropathy related pain and sensorimotor disorders. (24026991)
2013
5
Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. (23051637)
2013
6
Older subjects with diabetes and prediabetes are frequently unaware of having distal sensorimotor polyneuropathy: the KORA F4 study. (23275355)
2013
7
Identification and prediction of diabetic sensorimotor polyneuropathy using individual and simple combinations of nerve conduction study parameters. (23533591)
2013
8
Ultrasonography of palm to elbow segment of median nerve in different degrees of diabetic polyneuropathy. (24269093)
2013
9
Evaluation of diabetic polyneuropathy in Type 2 diabetes mellitus by nerve conduction study and association of severity of neuropathy with serum sFasL level. (23565468)
2012
10
Heart rate variability and sensorimotor polyneuropathy in type 1 diabetes. (22357183)
2012
11
Efficacy and safety of antioxidant treatment with I+-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. (21775755)
2011
12
Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy. (21996793)
2011
13
Ramsay Hunt syndrome with unilateral polyneuropathy involving cranial nerves V, VII, VIII, and XII in a diabetic patient. (22026001)
2011
14
Dorsal versus ventral monofilament testing of the great toe for the identification of diabetic sensorimotor polyneuropathy. (21632138)
2011
15
Muscle weakness and other late complications of diabetic polyneuropathy. (22384769)
2011
16
A Comparative study of examination scores and quantitative sensory testing in diagnosis of diabetic polyneuropathy. (20431806)
2010
17
Comparison of the sensitivities of plantar nerve conduction techniques for early detection of diabetic sensory polyneuropathy. (21061773)
2010
18
Prevalence of distal diabetic polyneuropathy using quantitative sensory methods in a population with diabetes of more than 10 years' disease duration. (20638348)
2010
19
Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial. (19399887)
2009
20
Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany). (19131463)
2009
21
Impaired distal thermoregulation in diabetes and diabetic polyneuropathy. (19196899)
2009
22
Clinical screening and diagnosis of diabetic polyneuropathy: the North Catalonia Diabetes Study. (19260947)
2009
23
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
24
Chronic inflammatory demyelinating polyneuropathy in a diabetic patient: deterioration after intravenous immunoglobulins treatment and favorable response to steroid treatment. (17569228)
2007
25
Aldose reductase inhibitors for the treatment of diabetic polyneuropathy. (17943821)
2007
26
High prevalence of diabetic polyneuropathy in a group of Brazilian children with type 1 diabetes mellitus. (16459455)
2005
27
Chronic inflammatory demyelinating polyneuropathy after Campylobacter jejuni infection mimicking vasculitic mononeuritis multiplex in a diabetic. (15104697)
2004
28
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. (14984445)
2004
29
The possible role of tumor necrosis factor-alpha in diabetic polyneuropathy. (14630568)
2003
30
Diabetic demyelinating polyneuropathy responsive to intravenous immunoglobulin therapy. (12020256)
2002
31
Symmetry of nerve conduction studies in different stages of diabetic polyneuropathy. (11870689)
2002
32
The role of glycation in the pathogenesis of diabetic polyneuropathy. (11724915)
2001
33
Prevalence and risk factors of clinical diabetic polyneuropathy in a Portuguese primary health care population. (11547224)
2001
34
Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. (10670912)
2000
35
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. (10595592)
1999
36
Specific fiber deficits in sensorimotor diabetic polyneuropathy correspond to cytotoxicity against neuroblastoma cells of sera from patients with diabetes. (10546017)
1999
37
Effects of the aldose reductase inhibitor on diabetic polyneuropathy--the efficacy of F wave measurement]. (9789304)
1998
38
Biochemical studies of amyloidogenesis in two different types of amyloidoses--amyloid transthyretin variant in familial amyloidotic polyneuropathy and islet amyloid polypeptide in non-insulin-dependent diabetes mellitus]. (7665954)
1995
39
Basement membrane reduplication and pericyte degeneration precede development of diabetic polyneuropathy and are associated with its severity. (7717686)
1995
40
Efficiency of the antihypoxic substance sabeluzole in patients with clinically and neurophysiologically evident diabetic polyneuropathy. (8296540)
1993
41
Autonomic system dysfunction in moderate diabetic polyneuropathy assessed by sympathetic skin response and Valsalva index. (8261984)
1993
42
Clinical examination versus neurophysiological examination in the diagnosis of diabetic polyneuropathy. (1395463)
1992
43
Sensory testing versus nerve conduction velocity in diabetic polyneuropathy. (1470197)
1992
44
Electrophysiologic evolution of diabetic polyneuropathy after combined pancreas and renal transplantation. (1604648)
1992
45
Variability of three standard neurophysiological techniques in established symptomatic diabetic polyneuropathy. (2635095)
1989
46
F-wave latencies of the deep peroneal nerve in diabetic polyneuropathy. (2689154)
1989
47
Diabetic polyneuropathy and insulin secretion in type II diabetic patients. (3315688)
1987
48
Diabetic polyneuropathy. (3332444)
1987
49
Analysis of conduction velocity in the H pathway. Part 2. An electrophysiological study in diabetic polyneuropathy. (7276975)
1981
50
Osteosclerotic "plasmocytoma" with polyneuropathy, hypertrichosis and diabetes. (645443)
1978

Genetic Variations for Diabetic Polyneuropathy

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Expression for genes affiliated with Diabetic Polyneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Polyneuropathy

Search GEO for disease gene expression data for Diabetic Polyneuropathy.

Pathways for genes affiliated with Diabetic Polyneuropathy

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49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CAT, GPX1
210.0GSTT1, GSTM1
310.0GSTT1, GSTM1
49.8CAT, SOD3, GPX1
5
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9.8CNTF, LIF, SOD2
6
Naphthalene metabolism
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9.8AKR1B1, GSTM1, GSTT1
79.8SOD2, SOD3, CAT
8
Glutathione metabolism
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9.8GPX1, GSTM1, GSTT1
99.8NOS3, THBD, LIF
10
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9.7NOS1, GPX1, CAT
119.6CAT, SOD3, SOD2, GPX1
129.6CAT, SOD3, SOD2, GPX1
139.6NOS2, SOD2, CAT
149.5NOS3, NOS2, NOS1
15
NO-dependent CFTR activation (normal and CF)
9.5NOS3, NOS2, NOS1
169.5NOS3, NOS2, NOS1
17
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9.5NOS1, NOS2, NOS3
18
CFTR folding and maturation (norm and CF)
9.5NOS1, NOS2, NOS3
19
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9.3NOS2, NOS3, GPX1, CAT
209.3SLC25A4, NOS3, NOS2, NOS1
21
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9.3THBD, NOS3, NOS2, NOS1
22
Hide members
8.6GPX1, SLC25A4, NOS3, NOS2, NOS1, GSTM1

Compounds for genes affiliated with Diabetic Polyneuropathy

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 243)
idCompoundScoreTop Affiliating Genes
1tetrahydrobiopterin44 11 2412.1NOS3, NOS1, AKR1B1
2cycloheximide4410.0PARP1, SOD2, CAT
3nadph44 2411.0SOD3, SOD2, GPX1, NOS1
4indomethacin44 59 28 1112.9NOS1, NOS3, NGF, AKR1B1
5alpha tocopherol449.8GPX1, GSTM1, LIF, SOD2
6norepinephrine44 11 2411.8NTF3, BMP6, LIF, CNTF
78-oxo-dg449.6SOD2, GSTT1, CAT, GSTM1, GPX1
8gamma-glutamylcysteine44 11 2411.6GPX1, GSTM1, CAT, SOD3, SOD2
9superoxide44 2410.5SOD3, NOS1, NOS3, CNTF, NTF3, LIF
10ptio449.5NOS2, NOS3, NOS1, CAT
11onoo449.5SOD2, NOS3, NOS1, NOS2
12aminoguanidine44 28 1111.5SOD2, AKR1B1, NOS3, NOS2, NOS1
13cyclosporin a44 28 5911.5NOS1, AKR1B1, THBD, NGF, LIF, SLC25A4
14pdtc449.4CAT, NGF, NOS2, NOS1, SOD2
15vitamin-e449.4GSTT1, NTF3, CAT, CNTF, THBD, GPX1
16manganese superoxide449.4GSTM1, GPX1, SOD2, CAT, SOD3, GSTT1
17malondialdehyde449.4GSTT1, GSTM1, GPX1, SOD2, SOD3, CAT
18h2o2449.3CAT, AKR1B1, LIF, CNTF, PARP1, THBD
19selenium44 2410.3LIF, GPX1, SOD2, CAT, SOD3
20choline44 11 2411.1NOS1, NOS3, NGF, NTF3, LIF, CNTF
21silymarin449.1NOS2, CAT, BMP6, AKR1B1, PARP1
22s-nitroso-n-acetylpenicillamine449.1NOS3, NOS1, NOS2, AKR1B1, CAT, PARP1
23folate449.1GSTT1, GSTM1, NOS1, NOS3, SOD2, SOD3
24vitamin d449.1GSTM1, THBD, NGF, BMP6, SOD2, SOD3
25carbachol44 28 1111.0NOS1, NTF3, NGF, LIF, BMP6, NOS3
264-hydroxynonenal44 2410.0PARP1, NOS2, GPX1, CAT, GSTM1, SOD2
27dopamine44 28 11 2412.0NOS1, BMP6, GSTM1, SOD2, CNTF, LIF
28betacarotene448.9SOD2, LIF, THBD, CAT, GSTM1
29oxygen44 249.9NOS1, NOS2, SOD3, AKR1B1, POLG, SLC25A4
30creatinine448.9NGF, BMP6, GSTT1, GSTM1, AKR1B1, SLC25A4
31n acetylcysteine448.9PARP1, NOS2, CNTF, CAT, SOD3, GPX1
32adenylate448.9SLC25A4, SOD3, AKR1B1, NTF3, POLG, CNTF
33curcumin448.8CAT, SOD2, AKR1B1, NOS2, PARP1, THBD
34sodium nitroprusside448.8NOS3, NOS1, CAT, SOD2, BMP6, NOS2
35peroxynitrite448.7NOS1, CAT, SOD3, SOD2, GPX1, NOS3
36lactate448.7BMP6, AKR1B1, LIF, SOD2, CAT, THBD
37ly294002448.6SOD2, BMP6, CNTF, NGF, NOS2, PARP1
38cisplatin44 49 59 1111.6LIF, GSTT1, GSTM1, PARP1, SOD2, BMP6
39alanine448.5NGF, GPX1, THBD, SOD2, CNTF, POLG
40sb 20358044 599.4CAT, BMP6, LIF, NGF, NOS3, NOS2
41genistein44 28 59 2 11 2413.4NTF3, LIF, AKR1B1, NOS2, NOS1, NOS3
42acetylcholine44 49 28 11 2412.3SOD3, BMP6, NTF3, NGF, LIF, SOD2
43actinomycin d448.2NGF, LIF, AKR1B1, SOD2, NTF3, CNTF
44retinoic acid44 249.2NGF, NOS1, NOS3, SLC25A4, THBD, CNTF
45cysteine448.1NTF3, SOD3, PARP1, NOS1, THBD, GPX1
46ascorbic acid44 248.9GSTM1, NOS1, NOS2, NOS3, THBD, CNTF
47arginine447.9NTF3, NGF, GSTM1, THBD, NOS3, NOS1
48nitric oxide44 11 249.8SOD3, GPX1, THBD, NOS1, NOS2, NOS3
49doxorubicin44 49 119.8GPX1, PARP1, GSTM1, NOS1, NOS2, NOS3
50vegf447.6NOS3, THBD, NGF, CNTF, NTF3, LIF

GO Terms for genes affiliated with Diabetic Polyneuropathy

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16Gene Ontology
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Cellular components related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial nucleoidGO:0426459.7POLG, SOD2, C10orf2
2extracellular spaceGO:0056159.1SOD3, BMP6, AKR1B1, LIF, CNTF, NGF
3cytosolGO:0058297.9NOS1, NOS2, NOS3, GPX1, AKR1B1, SOD3

Biological processes related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1mitochondrial DNA replicationGO:00626410.3POLG, C10orf2
2muscle organ morphogenesisGO:04864410.3LIF, CNTF
3response to selenium ionGO:01026910.2GPX1, SOD2
4negative regulation of platelet activationGO:01054410.1THBD, NOS3
5negative regulation of hydrolase activityGO:05134610.1NOS1, NOS3
6negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.1NOS3, GPX1
7neuron developmentGO:04866610.1CNTF, LIF, SOD2
8removal of superoxide radicalsGO:01943010.1SOD3, SOD2
9peptidyl-cysteine S-nitrosylationGO:01811910.1NOS1, NOS2
10negative regulation of neuron apoptotic processGO:04352410.0SOD2, NTF3, CNTF, NGF
11negative regulation of potassium ion transportGO:0432679.9NOS3, NOS1
12response to hyperoxiaGO:0550939.9SOD2, CAT
13UV protectionGO:0096509.9CAT, GPX1
14glutathione metabolic processGO:0067499.9GSTT1, GSTM1, GPX1, SOD2
15positive regulation of guanylate cyclase activityGO:0312849.9NOS1, NOS2, NOS3
16arginine catabolic processGO:0065279.9NOS3, NOS2, NOS1
17nitric oxide biosynthetic processGO:0068099.8NOS3, NOS2, NOS1
18nitric oxide mediated signal transductionGO:0072639.8NOS1, NOS2, NOS3
19positive regulation of vasodilationGO:0459099.8NOS3, NOS2, NOS1
20negative regulation of blood pressureGO:0457769.8NOS3, NOS2, NOS1
21interaction with hostGO:0517019.8NOS3, NOS2, NOS1
22phagosome maturationGO:0903829.8NOS1, NOS2, NOS3
23purine nucleotide catabolic processGO:0061959.7CAT, GPX1
24response to hypoxiaGO:0016669.4NOS1, NOS2, SOD2, SOD3, CAT
25small molecule metabolic processGO:0442819.0CAT, AKR1B1, GPX1, SLC25A4, NOS3, GSTM1

Molecular functions related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1superoxide dismutase activityGO:00478410.1SOD3, SOD2
2nitric-oxide synthase activityGO:0045179.8NOS1, NOS2, NOS3
3arginine bindingGO:0346189.7NOS3, NOS2, NOS1
4tetrahydrobiopterin bindingGO:0346179.7NOS3, NOS2, NOS1
5NADPH-hemoprotein reductase activityGO:0039589.7NOS1, NOS2, NOS3
6FMN bindingGO:0101819.6NOS1, NOS2, NOS3
7cadmium ion bindingGO:0468709.6NOS3, NOS1
8growth factor activityGO:0080839.5BMP6, LIF, NTF3, CNTF, NGF
9receptor bindingGO:0051029.4NOS2, NTF3, LIF, CAT
10NADP bindingGO:0506619.4CAT, NOS3, NOS2, NOS1
11flavin adenine dinucleotide bindingGO:0506609.4NOS1, NOS2, NOS3
12heme bindingGO:0200379.3CAT, NOS3, NOS2, NOS1

Products for genes affiliated with Diabetic Polyneuropathy

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Sources for Diabetic Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet