MCID: DBT004
MIFTS: 44

Diabetic Polyneuropathy malady

Endocrine diseases, Neuronal diseases categories

Aliases & Classifications for Diabetic Polyneuropathy

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 25ICD10
See all sources

Diabetic Polyneuropathy, Aliases & Descriptions:

Name: Diabetic Polyneuropathy 9 43
Diabetes Mellitus with Polyneuropathy 9
 
Polyneuropathy in Diabetes 9
Diabetic Polyneuropathies 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Neuronal diseases


Summaries for Diabetic Polyneuropathy

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MalaCards based summary: Diabetic Polyneuropathy, also known as diabetes mellitus with polyneuropathy, is related to polyneuropathy and neuropathy. An important gene associated with Diabetic Polyneuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Development HGF signaling pathway. The compounds valproate and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include testes, spinal cord and skin, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Related Diseases for Diabetic Polyneuropathy

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Graphical network of the top 20 diseases related to Diabetic Polyneuropathy:



Diseases related to diabetic polyneuropathy

Symptoms for Diabetic Polyneuropathy

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Drugs & Therapeutics for Diabetic Polyneuropathy

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Drug clinical trials:

Search ClinicalTrials for Diabetic Polyneuropathy

Search NIH Clinical Center for Diabetic Polyneuropathy

Genetic Tests for Diabetic Polyneuropathy

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Anatomical Context for Diabetic Polyneuropathy

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MalaCards organs/tissues related to Diabetic Polyneuropathy:

31
Testes, Spinal cord, Skin, Bone, Pancreas, Endothelial, Brain, Heart, Kidney, Thalamus

Animal Models for Diabetic Polyneuropathy or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Polyneuropathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9NTF3, AKR1B1, NGF
2MP:00053767.8NGF, SOD3, AKR1B1, NTF3
3MP:00107687.4NTF3, AKR1B1, SOD3, NGF, C10orf2

Publications for Diabetic Polyneuropathy

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Articles related to Diabetic Polyneuropathy:

(show top 50)    (show all 295)
idTitleAuthorsYear
1
Mechanical hyperalgesia in rats with diabetic polyneuropathy is selectively inhibited by local peripheral nociceptin/orphanin FQ receptor and A/-opioid receptor agonism. (25697471)
2015
2
Therapeutic efficacy of bone marrow-derived mononuclear cells in diabetic polyneuropathy is impaired with aging or diabetes. (25802721)
2015
3
Mobile biofeedback of heart rate variability in patients with diabetic polyneuropathy: a preliminary study. (24438496)
2014
4
Methodology for conduct of epidemiologic surveys and randomized controlled trials of diabetic polyneuropathy. (25410232)
2014
5
Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy. (24713310)
2014
6
Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. (24319678)
2013
7
Whither pathogenetic treatments for diabetic polyneuropathy? (23381942)
2013
8
Influence of a specific, biorhythmically defined physical stimulus on deficient vasomotion in small-caliber arterioles in the subcutis in patients with diabetic polyneuropathy. (24021603)
2013
9
Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. (23877983)
2013
10
Thermal threshold: research study on small fiber dysfunction in distal diabetic polyneuropathy. (22401337)
2012
11
Clinical and electrophysiological signs of diabetic polyneuropathy -- effect of glycemia and duration of diabetes mellitus. (22263377)
2011
12
Letter: diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients (diabetes metab j 2011;35:390-6). (22111049)
2011
13
Power spectral analyses of index finger skin blood perfusion in carpal tunnel syndrome and diabetic polyneuropathy. (21716676)
2011
14
Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. (21941444)
2011
15
Efficacy and safety of antioxidant treatment with I+-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. (21775755)
2011
16
Non-pharmacological correction of impaired microcirculation in children with diabetic polyneuropathy. (20151328)
2010
17
A Comparative study of examination scores and quantitative sensory testing in diagnosis of diabetic polyneuropathy. (20431806)
2010
18
A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. (19738078)
2009
19
The beneficial effects of C-Peptide on diabetic polyneuropathy. (20039008)
2009
20
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
21
Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients. (18054108)
2008
22
Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy. (17478005)
2007
23
Strength-duration properties in diabetic polyneuropathy. (17408800)
2007
24
Association of polymorphous markers Pro72Arg and C(-594)CC OF TP53 gene with diabetic polyneuropathy in patients with type 1 diabetes mellitus living in Moscow]. (18318116)
2007
25
Comparison of the utility of sympathetic skin response and current perception threshold examinations with conventional examinations for the early electrophysiological diagnosis of diabetic polyneuropathy. (17191732)
2006
26
Two-stage community-based screening model for estimating prevalence of diabetic polyneuropathy (KCIS no. 6). (15855798)
2005
27
The value of the Rydel-Seiffer tuning fork as a predictor of diabetic polyneuropathy compared with a neurothesiometer. (15154940)
2004
28
Effectiveness, tolerability, and impact on quality of life of the 5% lidocaine patch in diabetic polyneuropathy. (15210530)
2004
29
Animal models of human diabetic polyneuropathy. (12684353)
2003
30
Clinical diagnosis of diabetic polyneuropathy with the diabetic neuropathy symptom and diabetic neuropathy examination scores. (12610024)
2003
31
New insights into diabetic polyneuropathy. (12966130)
2003
32
Sodium valproate in painful diabetic polyneuropathy. (14616298)
2003
33
Hyperesthesia: an early manifestation of diabetic polyneuropathy. (12521185)
2002
34
Carpal tunnel syndrome in patients with diabetic polyneuropathy. (11874948)
2002
35
Nerve growth factor (NGF) in treatment of diabetic polyneuropathy. One hope less?]. (11433707)
2001
36
The role of glycation in the pathogenesis of diabetic polyneuropathy. (11724915)
2001
37
Status of current clinical trials in diabetic polyneuropathy. (11513337)
2001
38
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
39
Methods for assessing diabetic polyneuropathy: validity and reproducibility of the measurement of sensory symptom severity and nerve function tests. (10670907)
2000
40
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. (10595592)
1999
41
Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. (10227655)
1999
42
F-wave-duration in diabetic polyneuropathy. (9466603)
1998
43
Subacute uremic and diabetic polyneuropathy. (8995584)
1997
44
Motor nerve refractory period distribution assessed by two techniques in diabetic polyneuropathy. (7521291)
1994
45
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
46
Structural functional interactions in the natural history of diabetic polyneuropathy: a key to the understanding of neuropathic pain? (8334853)
1993
47
Diagnosis and therapy of diabetic polyneuropathy]. (8517070)
1993
48
Clinical examination versus neurophysiological examination in the diagnosis of diabetic polyneuropathy. (1395463)
1992
49
Effects of pancreatic transplantation on diabetic polyneuropathy. (1989323)
1991
50
Vasodilation induced by transcutaneous nerve stimulation in peripheral ischemia (Raynaud's phenomenon and diabetic polyneuropathy). (6982164)
1982

Variations for Diabetic Polyneuropathy

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Expression for genes affiliated with Diabetic Polyneuropathy

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Search GEO for disease gene expression data for Diabetic Polyneuropathy.

Pathways for genes affiliated with Diabetic Polyneuropathy

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Pathways related to Diabetic Polyneuropathy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.3NTF3, NGF
2
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.3NTF3, NGF
3
Show member pathways
9.3NGF, NTF3
49.3NTF3, NGF
5
Show member pathways
9.3NTF3, NGF
6
Show member pathways
9.3NTF3, NGF

Compounds for genes affiliated with Diabetic Polyneuropathy

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Compounds related to Diabetic Polyneuropathy according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1valproate439.8NTF3, AKR1B1
2streptozotocin439.8AKR1B1, NTF3
3alpha lipoic acid439.7AKR1B1, NGF
4capsaicin43 2810.7NGF, AKR1B1
5k252a439.7NTF3, NGF
6levodopa43 1210.7NGF, AKR1B1
7inositol439.7NTF3, AKR1B1
8desipramine43 49 1211.7NTF3, NGF
9ganglioside439.6NTF3, NGF
10anisomycin43 1210.6NTF3, NGF
11dihydrotestosterone43 28 24 1212.6AKR1B1, NGF
12cocaine43 1210.6NGF, NTF3
13carbachol43 28 1211.6NGF, NTF3
14quercetin43 59 24 1212.5AKR1B1, NGF
15choline43 24 1211.5NGF, NTF3
16nicotine43 28 49 1212.3NTF3, NGF
17chloramphenicol43 2 49 1212.3NTF3, NGF
18glycerol43 24 1211.3AKR1B1, NGF
19nmda43 2810.3NTF3, AKR1B1, NGF
20norepinephrine43 24 1211.3NGF, AKR1B1, NTF3
21actinomycin d439.2NGF, AKR1B1, NTF3
22genistein43 28 59 2 24 1214.2NGF, AKR1B1, NTF3
23heparan sulfate43 2410.2SOD3, NTF3
24cycloheximide439.2NTF3, AKR1B1, NGF
25aspirin43 49 28 2412.1AKR1B1, NGF
26oxygen43 249.9NTF3, AKR1B1, SOD3
27acetylcholine43 49 28 24 1212.9NTF3, SOD3, NGF
28alanine438.8AKR1B1, SOD3, NGF
29adenylate438.5NTF3, AKR1B1, SOD3, NGF
30vegf438.4NGF, SOD3, AKR1B1, NTF3
31arginine438.4NGF, SOD3, AKR1B1, NTF3
32cysteine438.4NGF, SOD3, AKR1B1, NTF3

GO Terms for genes affiliated with Diabetic Polyneuropathy

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Cellular components related to Diabetic Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057968.7SOD3, NGF
2extracellular spaceGO:00056158.6AKR1B1, SOD3, NGF

Biological processes related to Diabetic Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:00435249.3NTF3, NGF
2peripheral nervous system developmentGO:00074229.2NTF3, NGF
3transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.0NTF3, NGF

Molecular functions related to Diabetic Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.3NTF3, NGF

Products for genes affiliated with Diabetic Polyneuropathy

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Sources for Diabetic Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet