MCID: DBT004
MIFTS: 57

Diabetic Polyneuropathy malady

Neuronal diseases category

Summaries for Diabetic Polyneuropathy

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MalaCards: Diabetic Polyneuropathy, also known as diabetes mellitus with polyneuropathy, is related to polyneuropathy and diabetic neuropathy. An important gene associated with Diabetic Polyneuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds tetrahydrobiopterin and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and pancreas, and related mouse phenotypes are adipose tissue and renal/urinary system.

Aliases & Classifications for Diabetic Polyneuropathy

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

diabetic polyneuropathy 8 44
diabetes mellitus with polyneuropathy 8
polyneuropathy in diabetes 8
diabetic polyneuropathies 60


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Disease Ontology8 DOID:12785
ICD9CM27 357.2
MeSH34 D003929
ICD1025 G63.2

Related Diseases for Diabetic Polyneuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy31.7CNTF, POLG, AKR1B1
2diabetic neuropathy30.7AKR1B1, CNTF, NTF3, NGF, SOD3
3neuropathy30.7NTF3, AKR1B1, SOD2, C10orf2, POLG, NGF
4diabetes mellitus30.6PARP1, NOS3, THBD, GPX1, NGF, AKR1B1
5diabetic autonomic neuropathy30.3NGF, AKR1B1
6autonomic neuropathy30.3AKR1B1, NGF, NTF3
7hyperglycemia30.1AKR1B1, GPX1, NOS3, CAT, NOS2, SOD2
8ischemia30.1CAT, SOD2, AKR1B1, NTF3, CNTF, GPX1
9neuroblastoma29.9NGF
10pancreatitis29.9SOD2
11type 2 diabetes mellitus29.9NGF, AKR1B1, NOS3, THBD, CAT
12obesity29.9AKR1B1, SOD2, CNTF, NOS3, NOS1, GSTM1
13type 1 diabetes mellitus10.4
14carpal tunnel syndrome10.3
15chronic polyneuropathy10.3
16demyelinating polyneuropathy10.2
17peripheral neuropathy10.2
18peritonitis10.0LIF
19cystitis10.0NGF
20eclampsia10.0THBD
21dilated cardiomyopathy10.0SLC25A4
22cerebrovascular disease10.0SOD3
23lupus erythematosus10.0THBD
24nephritis10.0LIF
25ophthalmoplegia10.0SLC25A4
26atopic dermatitis10.0NGF
27vasculitis10.0THBD
28hypogonadism10.0POLG
29choriocarcinoma10.0LIF
30meningioma10.0GSTT1
31pituitary tumors10.0LIF
32liver cirrhosis10.0NOS3
33migraine10.0GSTM1
34vitiligo10.0CAT
35lupus nephritis10.0THBD
36cystic fibrosis10.0GSTM1
37meningitis10.0CAT
38spermatic cord torsion10.0CAT
39pneumoconiosis10.0CAT
40graves' disease10.0NOS3
41sickle cell disease10.0NOS3
42glaucoma10.0CNTF, AKR1B1
43primary open angle glaucoma10.0GSTM1
44hepatopulmonary syndrome10.0NOS3
45blindness10.0AKR1B1, CNTF
46schistosomiasis10.0GSTM1
47mitochondrial disorders10.0POLG
48hypoglycemia10.0AKR1B1, POLG
49dermatitis10.0LIF, NTF3
50achalasia10.0NOS1

Graphical network of the top 20 diseases related to Diabetic Polyneuropathy:



Diseases related to diabetic polyneuropathy

Clinical Features for Diabetic Polyneuropathy

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Drugs & Therapeutics for Diabetic Polyneuropathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Polyneuropathy

Drug clinical trials:

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Genetic Tests for Diabetic Polyneuropathy

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Anatomical Context for Diabetic Polyneuropathy

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32MalaCards
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MalaCards organs/tissues related to Diabetic Polyneuropathy:

32
Testes, Skin, Pancreas, Endothelial, Bone, Spinal cord, Kidney, Heart, Brain, Thalamus

Animal Models for Diabetic Polyneuropathy or affiliated genes

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36MGI
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Publications for Diabetic Polyneuropathy

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50PubMed
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Articles related to Diabetic Polyneuropathy:

(show top 50)    (show all 325)
idTitleAuthorsYear
1
The antiallodynic action of nortriptyline and terbutaline is mediated by I^2 adrenoceptors and I' opioid receptors in the ob/ob model of diabetic polyneuropathy. (24361988)
2014
2
Conduction slowing in diabetic sensorimotor polyneuropathy. (24026550)
2013
3
Nerve ultrasound in diabetic polyneuropathy: correlation with clinical characteristics and electrodiagnostic testing. (23382089)
2013
4
H-reflex and clinical examination in the diagnosis of diabetic polyneuropathy. (22613432)
2012
5
Painful diabetic polyneuropathy: approach to diagnosis and management. (22209797)
2012
6
Impaired glycemia and diabetic polyneuropathy: the OC IG Survey. (22355020)
2012
7
Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey. (22949335)
2012
8
How sensitive is the case definition for diabetic sensorimotor polyneuropathy to the use of different symptoms, signs, and nerve conduction parameters in type 1 diabetes? (21227527)
2011
9
Electrodiagnosis of carpal tunnel syndrome in patients with diabetic polyneuropathy. (21330198)
2011
10
Small Fiber Neuropathy: Role in the diagnosis of Diabetic Sensorimotor Polyneuropathy. (21695760)
2011
11
A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. (19738078)
2009
12
Association between asymptomatic median mononeuropathy and diabetic polyneuropathy severity in patients with diabetes mellitus. (19059612)
2009
13
A splice variant of GNB3 and peripheral polyneuropathy in type 1 diabetes. (19597293)
2009
14
Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial. (19301937)
2009
15
Association of the T(-365)C POLG1, G(-25)A ANT1 and G(-605)T PEO1 gene polymorphisms with diabetic polyneuropathy in patients with type 1 diabetes mellitus]. (19425506)
2009
16
Efficacy and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin in post-herpetic neuralgia and diabetic polyneuropathy. (19480610)
2009
17
Electrophysiological patterns of diabetic polyneuropathy. (18551834)
2008
18
Clinical characteristics of patients with diabetic polyneuropathy: the role of clinical and electromyographic evaluation and the effect of the various types on the quality of life. (18410351)
2008
19
Sensory loss, pains, motor deficit and axonal regeneration in length-dependent diabetic polyneuropathy. (18825430)
2008
20
Diabetic polyneuropathy is associated with respiratory muscle impairment in type 2 diabetes. (18034226)
2008
21
Amino-terminal brain natriuretic peptide is related to the presence of diabetic polyneuropathy independently of cardiovascular disease. (17855271)
2007
22
Treating painful diabetic polyneuropathy. (17626918)
2007
23
Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study). (15726875)
2005
24
Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in patients with type 1 diabetes mellitus]. (15856945)
2005
25
Back to basics in diagnosing diabetic polyneuropathy with the tuning fork! (16123490)
2005
26
The value of the Rydel-Seiffer tuning fork as a predictor of diabetic polyneuropathy compared with a neurothesiometer. (15154940)
2004
27
Topiramate in painful diabetic polyneuropathy: findings from three double-blind placebo-controlled trials. (15355485)
2004
28
Distal site testing of sympathetic skin response (big toe) in diabetic polyneuropathy. (15666069)
2004
29
Clinical diagnosis of diabetic polyneuropathy with the diabetic neuropathy symptom and diabetic neuropathy examination scores. (12610024)
2003
30
New insights into diabetic polyneuropathy. (12966130)
2003
31
Hyperesthesia: an early manifestation of diabetic polyneuropathy. (12521185)
2002
32
Carpal tunnel syndrome in patients with diabetic polyneuropathy. (11874948)
2002
33
Long-term follow-up of diabetic polyneuropathy after simultaneous pancreas and kidney transplantation in type 1 diabetic patients. (11959247)
2002
34
Nerve growth factor (NGF) in treatment of diabetic polyneuropathy. One hope less?]. (11433707)
2001
35
Diabetic somatic polyneuropathy. Pathogenesis, clinical manifestations and therapeutic concepts]. (10923253)
2000
36
The extracellular matrix of peripheral nerve in diabetic polyneuropathy. (10805099)
2000
37
Risk factors for progression of distal symmetric polyneuropathy in type 1 diabetes mellitus. Sorbinil Retinopathy Trial Research Group. (10588075)
1999
38
Recombinant human nerve growth factor and diabetic polyneuropathy. (9748004)
1998
39
No evidence for axonal atrophy in human diabetic polyneuropathy. (9056539)
1997
40
Diabetic polyneuropathy in the elderly. Prevalence and risk factors in two geographic areas of Italy. Italian General Practitioner Study Group (IGPSG). (9325473)
1997
41
Diabetic polyneuropathy in controlled clinical trials: Consensus Report of the Peripheral Nerve Society. (7668839)
1995
42
Increased permeability across the blood-nerve barrier of albumin glycated in vitro and in vivo from patients with diabetic polyneuropathy. (1549585)
1992
43
Effects of pancreatic transplantation on diabetic polyneuropathy. (1989323)
1991
44
Freeze-fracture observations on normal and abnormal human perineurial tight junctions: alterations in diabetic polyneuropathy. (2058364)
1991
45
Relationship of endoneurial capillary abnormalities to type and severity of diabetic polyneuropathy. (2373263)
1990
46
Neuroaxonal dystrophy in distal symmetric sensory polyneuropathy of the diabetic BB-rat. (2533212)
1989
47
Intima of epineurial arterioles is increased in diabetic polyneuropathy. (3419603)
1988
48
Increased endoneurial albumin in diabetic polyneuropathy. (4069375)
1985
49
Treatment of painful diabetic polyneuropathy with mixed gangliosides. (6331137)
1984
50
Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study. (6801211)
1981

Genetic Variations for Diabetic Polyneuropathy

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Expression for genes affiliated with Diabetic Polyneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Polyneuropathy

Search GEO for disease gene expression data for Diabetic Polyneuropathy.

Pathways for genes affiliated with Diabetic Polyneuropathy

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49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome
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Pathways related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CAT, GPX1
210.0GSTT1, GSTM1
310.0GSTT1, GSTM1
49.8CAT, SOD3, GPX1
5
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9.8CNTF, LIF, SOD2
6
Naphthalene metabolism
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9.8AKR1B1, GSTM1, GSTT1
79.8SOD2, SOD3, CAT
8
Glutathione metabolism
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9.8GPX1, GSTM1, GSTT1
99.8NOS3, THBD, LIF
10
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9.7NOS1, GPX1, CAT
119.6CAT, SOD3, SOD2, GPX1
129.6CAT, SOD3, SOD2, GPX1
139.6NOS2, SOD2, CAT
149.5NOS3, NOS2, NOS1
15
NO-dependent CFTR activation (normal and CF)
9.5NOS3, NOS2, NOS1
169.5NOS3, NOS2, NOS1
17
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9.5NOS1, NOS2, NOS3
18
CFTR folding and maturation (norm and CF)
9.5NOS1, NOS2, NOS3
19
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9.3NOS2, NOS3, GPX1, CAT
209.3SLC25A4, NOS3, NOS2, NOS1
21
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9.3THBD, NOS3, NOS2, NOS1
22
Hide members
8.6GPX1, SLC25A4, NOS3, NOS2, NOS1, GSTM1

Compounds for genes affiliated with Diabetic Polyneuropathy

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 243)
idCompoundScoreTop Affiliating Genes
1tetrahydrobiopterin44 11 2412.1NOS3, NOS1, AKR1B1
2cycloheximide4410.0PARP1, SOD2, CAT
3nadph44 2411.0SOD3, SOD2, GPX1, NOS1
4indomethacin44 59 28 1112.9NOS1, NOS3, NGF, AKR1B1
5alpha tocopherol449.8GPX1, GSTM1, LIF, SOD2
6norepinephrine44 11 2411.8NTF3, BMP6, LIF, CNTF
78-oxo-dg449.6SOD2, GSTT1, CAT, GSTM1, GPX1
8gamma-glutamylcysteine44 11 2411.6GPX1, GSTM1, CAT, SOD3, SOD2
9superoxide44 2410.5SOD3, NOS1, NOS3, CNTF, NTF3, LIF
10ptio449.5NOS2, NOS3, NOS1, CAT
11onoo449.5SOD2, NOS3, NOS1, NOS2
12aminoguanidine44 28 1111.5SOD2, AKR1B1, NOS3, NOS2, NOS1
13cyclosporin a44 28 5911.5NOS1, AKR1B1, THBD, NGF, LIF, SLC25A4
14pdtc449.4CAT, NGF, NOS2, NOS1, SOD2
15vitamin-e449.4GSTT1, NTF3, CAT, CNTF, THBD, GPX1
16manganese superoxide449.4GSTM1, GPX1, SOD2, CAT, SOD3, GSTT1
17malondialdehyde449.4GSTT1, GSTM1, GPX1, SOD2, SOD3, CAT
18h2o2449.3CAT, AKR1B1, LIF, CNTF, PARP1, THBD
19selenium44 2410.3LIF, GPX1, SOD2, CAT, SOD3
20choline44 11 2411.1NOS1, NOS3, NGF, NTF3, LIF, CNTF
21silymarin449.1NOS2, CAT, BMP6, AKR1B1, PARP1
22s-nitroso-n-acetylpenicillamine449.1NOS3, NOS1, NOS2, AKR1B1, CAT, PARP1
23folate449.1GSTT1, GSTM1, NOS1, NOS3, SOD2, SOD3
24vitamin d449.1GSTM1, THBD, NGF, BMP6, SOD2, SOD3
25carbachol44 28 1111.0NOS1, NTF3, NGF, LIF, BMP6, NOS3
264-hydroxynonenal44 2410.0PARP1, NOS2, GPX1, CAT, GSTM1, SOD2
27dopamine44 28 11 2412.0NOS1, BMP6, GSTM1, SOD2, CNTF, LIF
28betacarotene448.9SOD2, LIF, THBD, CAT, GSTM1
29oxygen44 249.9NOS1, NOS2, SOD3, AKR1B1, POLG, SLC25A4
30creatinine448.9NGF, BMP6, GSTT1, GSTM1, AKR1B1, SLC25A4
31n acetylcysteine448.9PARP1, NOS2, CNTF, CAT, SOD3, GPX1
32adenylate448.9SLC25A4, SOD3, AKR1B1, NTF3, POLG, CNTF
33curcumin448.8CAT, SOD2, AKR1B1, NOS2, PARP1, THBD
34sodium nitroprusside448.8NOS3, NOS1, CAT, SOD2, BMP6, NOS2
35peroxynitrite448.7NOS1, CAT, SOD3, SOD2, GPX1, NOS3
36lactate448.7BMP6, AKR1B1, LIF, SOD2, CAT, THBD
37ly294002448.6SOD2, BMP6, CNTF, NGF, NOS2, PARP1
38cisplatin44 49 59 1111.6LIF, GSTT1, GSTM1, PARP1, SOD2, BMP6
39alanine448.5NGF, GPX1, THBD, SOD2, CNTF, POLG
40sb 20358044 599.4CAT, BMP6, LIF, NGF, NOS3, NOS2
41genistein44 28 59 2 11 2413.4NTF3, LIF, AKR1B1, NOS2, NOS1, NOS3
42acetylcholine44 49 28 11 2412.3SOD3, BMP6, NTF3, NGF, LIF, SOD2
43actinomycin d448.2NGF, LIF, AKR1B1, SOD2, NTF3, CNTF
44retinoic acid44 249.2NGF, NOS1, NOS3, SLC25A4, THBD, CNTF
45cysteine448.1NTF3, SOD3, PARP1, NOS1, THBD, GPX1
46ascorbic acid44 248.9GSTM1, NOS1, NOS2, NOS3, THBD, CNTF
47arginine447.9NTF3, NGF, GSTM1, THBD, NOS3, NOS1
48nitric oxide44 11 249.8SOD3, GPX1, THBD, NOS1, NOS2, NOS3
49doxorubicin44 49 119.8GPX1, PARP1, GSTM1, NOS1, NOS2, NOS3
50vegf447.6NOS3, THBD, NGF, CNTF, NTF3, LIF

GO Terms for genes affiliated with Diabetic Polyneuropathy

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16Gene Ontology
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Cellular components related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial nucleoidGO:0426459.7POLG, SOD2, C10orf2
2extracellular spaceGO:0056159.1SOD3, BMP6, AKR1B1, LIF, CNTF, NGF
3cytosolGO:0058297.9NOS1, NOS2, NOS3, GPX1, AKR1B1, SOD3

Biological processes related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1mitochondrial DNA replicationGO:00626410.3POLG, C10orf2
2muscle organ morphogenesisGO:04864410.3LIF, CNTF
3response to selenium ionGO:01026910.2GPX1, SOD2
4negative regulation of platelet activationGO:01054410.1THBD, NOS3
5negative regulation of hydrolase activityGO:05134610.1NOS1, NOS3
6negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.1NOS3, GPX1
7neuron developmentGO:04866610.1CNTF, LIF, SOD2
8removal of superoxide radicalsGO:01943010.1SOD3, SOD2
9peptidyl-cysteine S-nitrosylationGO:01811910.1NOS1, NOS2
10negative regulation of neuron apoptotic processGO:04352410.0SOD2, NTF3, CNTF, NGF
11negative regulation of potassium ion transportGO:0432679.9NOS3, NOS1
12response to hyperoxiaGO:0550939.9SOD2, CAT
13UV protectionGO:0096509.9CAT, GPX1
14glutathione metabolic processGO:0067499.9GSTT1, GSTM1, GPX1, SOD2
15positive regulation of guanylate cyclase activityGO:0312849.9NOS1, NOS2, NOS3
16arginine catabolic processGO:0065279.9NOS3, NOS2, NOS1
17nitric oxide biosynthetic processGO:0068099.8NOS3, NOS2, NOS1
18nitric oxide mediated signal transductionGO:0072639.8NOS1, NOS2, NOS3
19positive regulation of vasodilationGO:0459099.8NOS3, NOS2, NOS1
20negative regulation of blood pressureGO:0457769.8NOS3, NOS2, NOS1
21interaction with hostGO:0517019.8NOS3, NOS2, NOS1
22phagosome maturationGO:0903829.8NOS1, NOS2, NOS3
23purine nucleotide catabolic processGO:0061959.7CAT, GPX1
24response to hypoxiaGO:0016669.4NOS1, NOS2, SOD2, SOD3, CAT
25small molecule metabolic processGO:0442819.0CAT, AKR1B1, GPX1, SLC25A4, NOS3, GSTM1

Molecular functions related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1superoxide dismutase activityGO:00478410.1SOD3, SOD2
2nitric-oxide synthase activityGO:0045179.8NOS1, NOS2, NOS3
3arginine bindingGO:0346189.7NOS3, NOS2, NOS1
4tetrahydrobiopterin bindingGO:0346179.7NOS3, NOS2, NOS1
5NADPH-hemoprotein reductase activityGO:0039589.7NOS1, NOS2, NOS3
6FMN bindingGO:0101819.6NOS1, NOS2, NOS3
7cadmium ion bindingGO:0468709.6NOS3, NOS1
8growth factor activityGO:0080839.5BMP6, LIF, NTF3, CNTF, NGF
9receptor bindingGO:0051029.4NOS2, NTF3, LIF, CAT
10NADP bindingGO:0506619.4CAT, NOS3, NOS2, NOS1
11flavin adenine dinucleotide bindingGO:0506609.4NOS1, NOS2, NOS3
12heme bindingGO:0200379.3CAT, NOS3, NOS2, NOS1

Products for genes affiliated with Diabetic Polyneuropathy

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Sources for Diabetic Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet