MCID: DBT004
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Diabetic Polyneuropathy malady

Neuronal diseases category

Summaries for Diabetic Polyneuropathy

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34MalaCards
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MalaCards: Diabetic Polyneuropathy, also known as diabetes mellitus with polyneuropathy, is related to polyneuropathy and neuropathy. An important gene associated with Diabetic Polyneuropathy is AKR1B1 (aldo-keto reductase family 1, member B1 (aldose reductase)), and among its related pathways are Cell adhesion Integrin mediated cell adhesion and migration and Development HGF signaling pathway. The compounds valproate and streptozotocin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and pancreas, and related mouse phenotypes are vision/eye and homeostasis/metabolism.

Aliases & Classifications for Diabetic Polyneuropathy

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

diabetic polyneuropathy 9 46
diabetes mellitus with polyneuropathy 9
polyneuropathy in diabetes 9
diabetic polyneuropathies 63


External Ids:

Disease Ontology9 DOID:12785
MeSH36 D003929
ICD9CM28 357.2
ICD1026 G63.2

Related Diseases for Diabetic Polyneuropathy

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Diabetic Polyneuropathy:



Diseases related to diabetic polyneuropathy

Symptoms for Diabetic Polyneuropathy

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Drugs & Therapeutics for Diabetic Polyneuropathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Diabetic Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Polyneuropathy

Search NIH Clinical Center for Diabetic Polyneuropathy

Search CenterWatch for Diabetic Polyneuropathy

Genetic Tests for Diabetic Polyneuropathy

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Anatomical Context for Diabetic Polyneuropathy

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34MalaCards
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MalaCards organs/tissues related to Diabetic Polyneuropathy:

34
Testes, Skin, Pancreas, Bone, Spinal cord, Endothelial, Brain, Kidney, Thalamus

Animal Models for Diabetic Polyneuropathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetic Polyneuropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9NTF3, AKR1B1, NGF
2MP:00053767.8NGF, SOD3, AKR1B1, NTF3
3MP:00107687.4NTF3, AKR1B1, SOD3, NGF, C10orf2

Publications for Diabetic Polyneuropathy

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53PubMed
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Articles related to Diabetic Polyneuropathy:

(show top 50)    (show all 261)
idTitleAuthorsYear
1
Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. (24319678)
2013
2
Whither pathogenetic treatments for diabetic polyneuropathy? (23381942)
2013
3
Influence of a specific, biorhythmically defined physical stimulus on deficient vasomotion in small-caliber arterioles in the subcutis in patients with diabetic polyneuropathy. (24021603)
2013
4
Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. (23877983)
2013
5
Thermal threshold: research study on small fiber dysfunction in distal diabetic polyneuropathy. (22401337)
2012
6
Clinical and electrophysiological signs of diabetic polyneuropathy -- effect of glycemia and duration of diabetes mellitus. (22263377)
2011
7
Letter: diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients (diabetes metab j 2011;35:390-6). (22111049)
2011
8
Power spectral analyses of index finger skin blood perfusion in carpal tunnel syndrome and diabetic polyneuropathy. (21716676)
2011
9
Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. (21941444)
2011
10
Efficacy and safety of antioxidant treatment with I+-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. (21775755)
2011
11
Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy. (21996793)
2011
12
Recommendations for diabetic polyneuropathy treatment. (22263398)
2011
13
Non-pharmacological correction of impaired microcirculation in children with diabetic polyneuropathy. (20151328)
2010
14
A Comparative study of examination scores and quantitative sensory testing in diagnosis of diabetic polyneuropathy. (20431806)
2010
15
A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. (19738078)
2009
16
The beneficial effects of C-Peptide on diabetic polyneuropathy. (20039008)
2009
17
Diabetic polyneuropathy may increase the handicap related to vestibular disease. (19427968)
2009
18
Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial. (19399887)
2009
19
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
20
Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients. (18054108)
2008
21
Rationale and usefulness of newly devised abbreviated diagnostic criteria and staging for diabetic polyneuropathy. (17478005)
2007
22
Strength-duration properties in diabetic polyneuropathy. (17408800)
2007
23
Association of polymorphous markers Pro72Arg and C(-594)CC OF TP53 gene with diabetic polyneuropathy in patients with type 1 diabetes mellitus living in Moscow]. (18318116)
2007
24
Comparison of the utility of sympathetic skin response and current perception threshold examinations with conventional examinations for the early electrophysiological diagnosis of diabetic polyneuropathy. (17191732)
2006
25
Two-stage community-based screening model for estimating prevalence of diabetic polyneuropathy (KCIS no. 6). (15855798)
2005
26
The value of the Rydel-Seiffer tuning fork as a predictor of diabetic polyneuropathy compared with a neurothesiometer. (15154940)
2004
27
Effectiveness, tolerability, and impact on quality of life of the 5% lidocaine patch in diabetic polyneuropathy. (15210530)
2004
28
Treatment of diabetic polyneuropathy with alpha-lipoic acid is evidence based. (15529620)
2004
29
Animal models of human diabetic polyneuropathy. (12684353)
2003
30
Clinical diagnosis of diabetic polyneuropathy with the diabetic neuropathy symptom and diabetic neuropathy examination scores. (12610024)
2003
31
New insights into diabetic polyneuropathy. (12966130)
2003
32
Sodium valproate in painful diabetic polyneuropathy. (14616298)
2003
33
Hyperesthesia: an early manifestation of diabetic polyneuropathy. (12521185)
2002
34
Carpal tunnel syndrome in patients with diabetic polyneuropathy. (11874948)
2002
35
Nerve growth factor (NGF) in treatment of diabetic polyneuropathy. One hope less?]. (11433707)
2001
36
The role of glycation in the pathogenesis of diabetic polyneuropathy. (11724915)
2001
37
Status of current clinical trials in diabetic polyneuropathy. (11513337)
2001
38
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
39
Methods for assessing diabetic polyneuropathy: validity and reproducibility of the measurement of sensory symptom severity and nerve function tests. (10670907)
2000
40
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. (10595592)
1999
41
Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. (10227655)
1999
42
F-wave-duration in diabetic polyneuropathy. (9466603)
1998
43
Subacute uremic and diabetic polyneuropathy. (8995584)
1997
44
Motor nerve refractory period distribution assessed by two techniques in diabetic polyneuropathy. (7521291)
1994
45
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
46
Diagnosis and therapy of diabetic polyneuropathy]. (8517070)
1993
47
Clinical examination versus neurophysiological examination in the diagnosis of diabetic polyneuropathy. (1395463)
1992
48
Effects of pancreatic transplantation on diabetic polyneuropathy. (1989323)
1991
49
Variability of three standard neurophysiological techniques in established symptomatic diabetic polyneuropathy. (2635095)
1989
50
Vasodilation induced by transcutaneous nerve stimulation in peripheral ischemia (Raynaud's phenomenon and diabetic polyneuropathy). (6982164)
1982

Variations for Diabetic Polyneuropathy

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Expression for genes affiliated with Diabetic Polyneuropathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Polyneuropathy

Search GEO for disease gene expression data for Diabetic Polyneuropathy.

Pathways for genes affiliated with Diabetic Polyneuropathy

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 58SinoBiological, 55R&D Systems, 56Reactome
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Pathways related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility61
Cytoskeleton remodeling Integrin outside in signaling61
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases61
Cell adhesion Tight junctions61
Development MAG dependent inhibition of neurite outgrowth61
9.3NTF3, NGF
2
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.3NTF3, NGF
3
Show member pathways
9.3NGF, NTF3
49.3NTF3, NGF
5
Show member pathways
9.3NTF3, NGF
6
Show member pathways
9.3NTF3, NGF

Compounds for genes affiliated with Diabetic Polyneuropathy

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46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1valproate469.8NTF3, AKR1B1
2streptozotocin469.8AKR1B1, NTF3
3alpha lipoic acid469.7AKR1B1, NGF
4capsaicin46 3010.7NGF, AKR1B1
5k252a469.7NTF3, NGF
6levodopa46 1210.7NGF, AKR1B1
7inositol469.7NTF3, AKR1B1
8desipramine46 52 1211.7NTF3, NGF
9ganglioside469.6NTF3, NGF
10anisomycin46 1210.6NTF3, NGF
11dihydrotestosterone46 30 25 1212.6AKR1B1, NGF
12cocaine46 1210.6NGF, NTF3
13carbachol46 30 1211.6NGF, NTF3
14quercetin46 62 25 1212.5AKR1B1, NGF
15choline46 25 1211.5NGF, NTF3
16nicotine46 30 52 1212.3NTF3, NGF
17chloramphenicol46 3 52 1212.3NTF3, NGF
18glycerol46 25 1211.3AKR1B1, NGF
19nmda46 3010.3NTF3, AKR1B1, NGF
20norepinephrine46 25 1211.3NGF, AKR1B1, NTF3
21actinomycin d469.2NGF, AKR1B1, NTF3
22genistein46 30 62 3 25 1214.2NGF, AKR1B1, NTF3
23heparan sulfate46 2510.2SOD3, NTF3
24cycloheximide469.2NTF3, AKR1B1, NGF
25aspirin46 52 30 2512.1AKR1B1, NGF
26oxygen46 259.9NTF3, AKR1B1, SOD3
27acetylcholine46 52 30 25 1212.9NTF3, SOD3, NGF
28alanine468.8AKR1B1, SOD3, NGF
29adenylate468.5NTF3, AKR1B1, SOD3, NGF
30vegf468.4NGF, SOD3, AKR1B1, NTF3
31arginine468.4NGF, SOD3, AKR1B1, NTF3
32cysteine468.4NGF, SOD3, AKR1B1, NTF3

GO Terms for genes affiliated with Diabetic Polyneuropathy

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17Gene Ontology
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Cellular components related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057968.7SOD3, NGF
2extracellular spaceGO:0056158.6AKR1B1, SOD3, NGF

Biological processes related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3NTF3, NGF
2peripheral nervous system developmentGO:0074229.2NTF3, NGF
3transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.0NTF3, NGF

Molecular functions related to Diabetic Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3NTF3, NGF

Products for genes affiliated with Diabetic Polyneuropathy

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Sources for Diabetic Polyneuropathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet