MCID: DBT011
MIFTS: 70

Diabetic Retinopathy malady

Eye diseases category

Summaries for Diabetic Retinopathy

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66Wikipedia, 34MalaCards
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Wikipedia:66 Diabetic retinopathy, ([?r?tn??p??i]) is retinopathy (damage to the retina) caused by complications of... more...

MalaCards: Diabetic Retinopathy, also known as retinal abnormality - diabetes-related, is related to proliferative diabetic retinopathy and diabetic macular edema. An important gene associated with Diabetic Retinopathy is VEGFA (vascular endothelial growth factor A), and among its related pathways are LDL Oxidation in Atherogenesis and amb2 Integrin signaling. The compounds cobalt chloride and diphenyleneiodonium have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and retina, and related mouse phenotypes are normal and liver/biliary system.

Aliases & Classifications for Diabetic Retinopathy

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Sources:
9Disease Ontology, 23GTR, 11DISEASES, 46Novoseek, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

diabetic retinopathy 9 23 11 46 32 63
retinal abnormality - diabetes-related 9


External Ids:

Disease Ontology9 DOID:8947
MeSH36 D003930
NCIt41 C34538
ICD9CM28 362.0
ICD1026 H36.0

Related Diseases for Diabetic Retinopathy

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Diabetic Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative diabetic retinopathy31.3FGF2, AGT, CTGF, GAD1, VTN, ICAM1
2diabetic macular edema31.2SERPINF1, VEGFA
3diabetes mellitus31.1AGT, CTGF, GAD1, VTN, ICAM1, ANGPT2
4proliferative vitreoretinopathy31.0TGFB2
5neovascular glaucoma31.0VEGFA
6retinal detachment31.0SERPINF1, TGFB2, VEGFA
7glaucoma31.0CTGF, SERPINF1, TGFB2
8type 2 diabetes mellitus30.9AGT, GAD1, ADM, VCAM1, IGFBP1, IGF1
9blindness30.8SERPINF1, TIMP3, VEGFA
10age related macular degeneration30.8TIMP3, VEGFA
11cataract30.8CTGF, SERPINF1, TGFB2
12type 1 diabetes mellitus30.7AGT, GAD1, IGFBP1, IGF1
13diabetic nephropathy30.7AGT, CTGF, ADM, SERPINF1, TIMP3, THBS1
14leukostasis30.7ICAM1, VCAM1
15retinal ischemia30.6HIF1A, VEGFA
16retinal vein occlusion30.6VEGFA
17macular holes30.5ANGPT2, ADM, SERPINF1, TGFB2
18proteinuria30.4AGT, CTGF, VTN, ANGPT2, ADM, VEGFA
19hypertension30.4AGT, ICAM1, ADM, VCAM1, IGF1
20eye disease30.4SERPINF1, TGFB2, IGFBP1
21insulin resistance30.3AGT, CTGF, VCAM1, IGFBP1, IGF1
22uveitis30.3ICAM1, SERPINF1, TGFB2
23obesity30.2AGT, HIF1A, IGFBP1, IGF1, THBS1
24hyperglycemia30.2AGT, CTGF, GAD1, VTN, VCAM1, SERPINF1
25coronary artery disease30.2AGT, VCAM1, THBS1
26ischemia30.2FGF2, AGT, CTGF, GAD1, VTN, ICAM1
27central retinal vein occlusion30.2VEGFA
28leukemia30.2FGF2, ICAM1, ANGPT2, CXCL12, SERPINF1, IGFBP1
29myocardial infarction30.2AGT, CTGF, CXCL12, ADM, HIF1A, IGFBP1
30laron syndrome30.1IGFBP1, IGF1
31retinal degeneration30.1FGF2, SERPINF1, TIMP3
32atherosclerosis30.1FGF2, AGT, CTGF, VTN, ICAM1, ANGPT2
33hypoglycemia30.0GAD1, HIF1A, IGFBP1, IGF1
34pre-eclampsia29.9AGT, ICAM1, ANGPT2, ADM, VCAM1, HIF1A
35osteoarthritis29.7FGF2, CTGF, ANGPT2, CXCL12, VCAM1, TGFB2
36retinitis11.1
37endotheliitis11.1
38background diabetic retinopathy10.6
39severe nonproliferative diabetic retinopathy10.5
40neuronitis10.5
41neuropathy10.5
42vitreous detachment10.4
43choroiditis10.4
44cystoid macular edema10.3
45retinal microaneurysm10.3
46hypoxia10.3
47rubeosis iridis10.2
48artery disease10.2
49retinal disease10.2
50acromegaly10.2

Graphical network of the top 20 diseases related to Diabetic Retinopathy:



Diseases related to diabetic retinopathy

Symptoms for Diabetic Retinopathy

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Drugs & Therapeutics for Diabetic Retinopathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Retinopathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Retinopathy

Search NIH Clinical Center for Diabetic Retinopathy

Search CenterWatch for Diabetic Retinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Retinopathy cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Retinopathy

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23GTR
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Genetic tests related to Diabetic Retinopathy:

id Genetic test Affiliating Genes
1 Diabetic Retinopathy23

Anatomical Context for Diabetic Retinopathy

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32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Diabetic Retinopathy:

34
Endothelial, Eye, Retina, Bone, Monocytes, Testes, Heart, Kidney, Placenta, Myeloid, Thyroid, T cells, Liver, Tongue, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Retinopathy:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeInner Nuclear LayerMature Muller Glia Cells Affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease

Animal Models for Diabetic Retinopathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diabetic Retinopathy:

38 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1VEGFA, HIF1A, CXCL12, VTN, GAD1, CTGF
2MP:00053707.8THBS1, IGFBP1, VEGFA, HIF1A, TIMP3, ADM
3MP:00020067.8THBS1, IGF1, VEGFA, HIF1A, ICAM1, FGF2
4MP:00107717.6THBS1, IGF1, VEGFA, HIF1A, TIMP3, ADM
5MP:00053807.4VEGFA, HIF1A, TGFB2, VCAM1, ADM, GAD1
6MP:00053717.4THBS1, IGF1, VEGFA, HIF1A, TGFB2, GAD1
7MP:00053817.2THBS1, VEGFA, HIF1A, TGFB2, SERPINF1, ANGPT2
8MP:00053677.1THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
9MP:00053797.0THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
10MP:00053886.8THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
11MP:00053916.8TIMP3, HIF1A, VEGFA, THBS1, TGFB2, SERPINF1
12MP:00053906.7THBS1, IGF1, VEGFA, HIF1A, TGFB2, GAD1
13MP:00053896.6THBS1, IGF1, VEGFA, TGFB2, SERPINF1, VCAM1
14MP:00036316.4IGF1, VEGFA, HIF1A, TGFB2, SERPINF1, CXCL12
15MP:00053696.1THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
16MP:00053786.0THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
17MP:00053975.9TIMP3, HIF1A, VEGFA, IGF1, THBS1, TGFB2
18MP:00053875.8HIF1A, VEGFA, IGFBP1, IGF1, THBS1, TIMP3
19MP:00053845.7HIF1A, VEGFA, IGFBP1, IGF1, THBS1, TIMP3
20MP:00053855.1FGF2, THBS1, IGF1, VEGFA, HIF1A, TIMP3
21MP:00053765.0TGFB2, TIMP3, HIF1A, VEGFA, IGF1, THBS1
22MP:00107684.9TGFB2, TIMP3, HIF1A, VEGFA, IGF1, THBS1

Publications for Diabetic Retinopathy

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53PubMed
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Articles related to Diabetic Retinopathy:

(show top 50)    (show all 1500)
idTitleAuthorsYear
1
Suppression of protein kinase C-IP attenuates vascular leakage via prevention of tight junction protein decrease in diabetic retinopathy. (24434146)
2014
2
Fourier-domain optical coherence tomography evaluation of retinal and optic nerve head neovascularisation in proliferative diabetic retinopathy. (24158844)
2014
3
Contemporary management of diabetic retinopathy in Canada: from guidelines to algorithm guidance. (24246998)
2014
4
Association study of sorbitol dehydrogenase -888G>C polymorphism with type 2 diabetic retinopathy in Caucasian-Brazilians. (23850972)
2013
5
Mitochondria damage in the pathogenesis of diabetic retinopathy and in the metabolic memory associated with its continued progression. (23745551)
2013
6
Screening intervals for diabetic retinopathy and incidence of visual loss: a systematic review. (23819487)
2013
7
Enzymatic vitrectomy for diabetic retinopathy and diabetic macular edema. (24379923)
2013
8
Editorial: possible therapeutic targets for the treatment of diabetic retinopathy: evidences from experimental models. (23173955)
2013
9
Association of angiotensin-converting enzyme gene 2350 G/A polymorphism with diabetic retinopathy in Chinese Han population. (23065222)
2013
10
Assessing the Need for Referral in Automatic Diabetic Retinopathy Detection. (23963192)
2013
11
Susceptibility genes, HLA and diabetic retinopathy in the Algerian population]. (22981956)
2013
12
Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy. (23037145)
2013
13
Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. (23633659)
2013
14
Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy. (23891690)
2013
15
Diabetes, diabetic retinopathy, and age-related macular degeneration: an unexpected relationship. (23470781)
2013
16
Relationship between diabetic retinopathy, microalbuminuria and overt nephropathy, and twenty-year incidence follow-up of a sample of type 1 diabetic patients. (22921286)
2012
17
Serum lipids and diabetic retinopathy: A cross-sectional study. (23565476)
2012
18
PEDF in diabetic retinopathy: a protective effect of oxidative stress. (22570532)
2012
19
Cysteine-rich 61 (CYR61) is up-regulated in proliferative diabetic retinopathy. (22160564)
2012
20
Plasma, aqueous and vitreous homocysteine levels in proliferative diabetic retinopathy. (22353698)
2012
21
Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy. (22180072)
2011
22
Intraocular expression of serum amyloid a and interleukin-6 in proliferative diabetic retinopathy. (21704966)
2011
23
Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy. (22125532)
2011
24
Diabetic retinopathy: An update on treatment. (20193825)
2010
25
Plasma and aqueous humor angiotensin-converting enzyme levels in patients with diabetic retinopathy. (20373882)
2010
26
Anti-VEGF therapy in proliferative diabetic retinopathy. (19349790)
2009
27
Diabetic retinopathy is not associated with carbonic anhydrase gene polymorphisms. (19536309)
2009
28
Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. (19404486)
2009
29
Morphologic changes in the anterior segment after phacovitrectomy for proliferative diabetic retinopathy. (19393886)
2009
30
Increased levels of monokine induced by interferon-gamma (Mig) in the vitreous of patients with diabetic retinopathy. (18644076)
2008
31
The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy. (18436850)
2008
32
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
33
Endothelin antagonism prevents diabetic retinopathy in NOD mice: a potential role of the angiogenic factor adrenomedullin. (16741057)
2006
34
The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy. (16705546)
2006
35
Risk factors of diabetic retinopathy in type 2 diabetic patients. (16732984)
2006
36
Angiopoietin concentrations in diabetic retinopathy. (15774928)
2005
37
Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization. (15181979)
2004
38
Aqueous levels of macrophage migration inhibitory factor and monocyte chemotactic protein-1 in patients with diabetic retinopathy. (15569131)
2004
39
-429T/C and -374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes. (12941744)
2003
40
BglII gene polymorphism of the alpha2beta1 integrin gene is a risk factor for diabetic retinopathy in Caucasians with type 2 diabetes. (12938014)
2003
41
eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy. (11918626)
2002
42
Detection of glutamate and gamma-aminobutyric acid in vitreous of patients with proliferative diabetic retinopathy. (12579648)
2000
43
Evidence that upregulation of serum IGF-1 concentration can trigger acceleration of diabetic retinopathy. (9924360)
1998
44
A 3-19-year follow-up study on diabetic retinopathy in patients diagnosed in childhood and treated with conventional therapy. (9400919)
1997
45
Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. (9298058)
1997
46
Screening for diabetic retinopathy. (7776911)
1995
47
The effect of diabetic control on diabetic retinopathy. (7607352)
1993
48
Asymmetric proliferative diabetic retinopathy and carotid artery disease. (2381700)
1990
49
Effect of pure O2-breathing on retinal blood flow in normals and in patients with background diabetic retinopathy. (6690224)
1984
50
Retinal ischemia (capillary nonperfusion) in diabetic retinopathy of patients with and without systemic hypertension. (745825)
1978

Variations for Diabetic Retinopathy

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Expression for genes affiliated with Diabetic Retinopathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Retinopathy

Search GEO for disease gene expression data for Diabetic Retinopathy.

Pathways for genes affiliated with Diabetic Retinopathy

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 13EMD Millipore, 31KEGG, 52PharmGKB, 58SinoBiological, 56Reactome, 5Cell Signaling Technology
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Pathways related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.7ICAM1, VTN, CTGF
3
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.6VEGFA, VCAM1, ICAM1
4
Show member pathways
9.6IGF1, TIMP3, VTN
59.5VEGFA, VTN, FGF2
69.5VCAM1, CXCL12, ICAM1
79.5VCAM1, CXCL12, ICAM1
8
Show member pathways
9.5VEGFA, TIMP3, FGF2
99.2VTN, IGF1, THBS1
109.1IGF1, VEGFA, HIF1A, ANGPT2
11
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.1VTN, HIF1A, VEGFA, IGF1
12
Show member pathways
Proteogylcan syndecan-mediated signaling events39
9.1THBS1, VTN, FGF2
139.1FGF2, AGT, IGF1
149.1AGT, HIF1A, IGF1
159.0THBS1, CXCL12, FGF2
16
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.0VTN, VEGFA, IGF1, THBS1
179.0VTN, ICAM1, VCAM1, THBS1
18
Show member pathways
Angiogenesis39
9.0FGF2, TIMP3, HIF1A, VEGFA
198.9IGFBP1, VEGFA, HIF1A, ADM, CXCL12
208.9VEGFA, TGFB2, FGF2
218.9TGFB2, HIF1A, VEGFA
228.8VEGFA, TGFB2, CXCL12, ICAM1
238.7THBS1, IGF1, VEGFA, FGF2
24
Show member pathways
Signaling Pathways in Glioblastoma39
8.7THBS1, IGF1, VEGFA, FGF2
25
Show member pathways
8.7ANGPT2, CXCL12, SERPINF1, TGFB2, VEGFA
268.6THBS1, VEGFA, TIMP3, TGFB2
27
Show member pathways
8.5THBS1, IGF1, VEGFA, ANGPT2, FGF2
28
Show member pathways
8.4THBS1, IGF1, VEGFA, TGFB2
298.4THBS1, TGFB2, VCAM1, ICAM1
308.3THBS1, IGF1, VEGFA, ANGPT2, VTN, FGF2
318.3IGF1, VEGFA, TIMP3, TGFB2, FGF2
32
Show member pathways
8.2ANGPT2, TGFB2, VEGFA, IGF1, THBS1
338.1HIF1A, TIMP3, TGFB2, ANGPT2, FGF2
348.0IGF1, VEGFA, HIF1A, TGFB2, FGF2
35
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
36
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
37
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
38
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
39
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
40
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
41
Show member pathways
7.8THBS1, TGFB2, VCAM1, CXCL12, ICAM1, VTN
42
Show member pathways
7.6IGF1, FGF2, CTGF, ANGPT2, CXCL12, TGFB2
43
Show member pathways
7.6CTGF, ANGPT2, CXCL12, TGFB2, TIMP3, IGF1
44
Show member pathways
7.6THBS1, TGFB2, VCAM1, ICAM1, VTN, FGF2
45
Show member pathways
7.4IGF1, TIMP3, TGFB2, SERPINF1, CXCL12, VTN
46
Show member pathways
7.2THBS1, IGF1, VEGFA, HIF1A, ADM, CXCL12
47
Show member pathways
7.2IGF1, TIMP3, TGFB2, CXCL12, ANGPT2, CTGF
48
Show member pathways
7.1IGF1, HIF1A, TIMP3, TGFB2, CXCL12, ANGPT2
496.9THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
50
Show member pathways
6.5FGF2, IGF1, HIF1A, TIMP3, TGFB2, VCAM1

Compounds for genes affiliated with Diabetic Retinopathy

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 25HMDB, 30IUPHAR, 52PharmGKB, 3BitterDB
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Compounds related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1cobalt chloride468.9VCAM1, HIF1A, ADM, VEGFA
2diphenyleneiodonium468.7SERPINF1, HIF1A, VEGFA, AGT, VCAM1, ICAM1
3l-nmma468.7ADM, IGF1, AGT, HIF1A, VCAM1
4herbimycin a46 629.6VCAM1, CXCL12, ICAM1, VTN, FGF2, IGFBP1
5mannitol46 129.5ICAM1, CTGF, ADM, VCAM1, HIF1A, FGF2
6ribonucleic acid467.9IGF1, CTGF, ANGPT2, THBS1, CXCL12, TGFB2
7potassium46 25 129.8SERPINF1, AGT, VTN, CXCL12, ADM, TGFB2
8tgf beta1467.8TIMP3, TGFB2, FGF2, THBS1, VCAM1, CTGF
9glycosaminoglycan467.8TGFB2, THBS1, CXCL12, TIMP3, SERPINF1, FGF2
10cytochalasin d46 628.8VTN, IGF1, CXCL12, ICAM1, FGF2, CTGF
11fibrinogen467.8ANGPT2, ICAM1, CXCL12, VCAM1, IGFBP1, VTN
12prostacyclin467.7FGF2, AGT, CTGF, VTN, ICAM1, ADM
13rapamycin467.7AGT, CTGF, HIF1A, VEGFA, IGFBP1, IGF1
14n acetylcysteine467.7VCAM1, AGT, CTGF, ICAM1, VEGFA, HIF1A
15creatinine467.6IGFBP1, IGF1, TGFB2, ADM, ANGPT2, AGT
16prostaglandin467.6TGFB2, CXCL12, AGT, THBS1, CTGF, ADM
17actinomycin d467.6IGF1, IGFBP1, VEGFA, HIF1A, ADM, CXCL12
18cholesterol46 30 25 1210.5AGT, THBS1, IGF1, IGFBP1, ADM, CXCL12
19hyaluronic acid46 258.5VEGFA, CXCL12, ICAM1, VTN, FGF2, TGFB2
20steroid467.4AGT, GAD1, ANGPT2, ADM, CXCL12, IGF1
21arginine467.4VTN, AGT, IGF1, GAD1, TIMP3, IGFBP1
22progesterone46 30 62 25 1211.3CXCL12, ADM, TGFB2, IGFBP1, IGF1, THBS1
23wortmannin467.3VTN, ANGPT2, CXCL12, ADM, VCAM1, TIMP3
24estradiol46 25 129.2IGF1, GAD1, IGFBP1, TIMP3, TGFB2, CXCL12
25h2o2467.1THBS1, AGT, CTGF, GAD1, HIF1A, SERPINF1
26testosterone46 62 25 1210.1VCAM1, IGF1, THBS1, IGFBP1, HIF1A, TIMP3
27tamoxifen46 52 30 129.9THBS1, IGF1, VTN, CXCL12, ADM, VCAM1
28sb 20358046 627.9THBS1, IGF1, VEGFA, HIF1A, FGF2, AGT
29oligonucleotide466.9AGT, GAD1, ADM, TGFB2, TIMP3, HIF1A
30paraffin466.6ADM, VCAM1, TIMP3, HIF1A, VEGFA, THBS1
31pd 98,059466.6FGF2, AGT, CTGF, VTN, ICAM1, CXCL12
32oxygen46 257.5TIMP3, HIF1A, IGFBP1, THBS1, SERPINF1, VCAM1
33cyclosporin a46 30 628.5CTGF, GAD1, FGF2, TGFB2, ICAM1, ADM
34heparin46 30 25 129.3VEGFA, SERPINF1, THBS1, IGFBP1, TIMP3, TGFB2
35nitric oxide46 25 128.3AGT, CTGF, GAD1, ICAM1, ANGPT2, ADM
36thymidine46 257.3ADM, TGFB2, HIF1A, IGFBP1, IGF1, THBS1
37pge2466.2HIF1A, VEGFA, IGFBP1, AGT, CTGF, VTN
38ly294002466.2ANGPT2, CXCL12, VCAM1, TIMP3, HIF1A, VEGFA
39cycloheximide466.2FGF2, CTGF, THBS1, IGF1, VTN, ICAM1
40matrigel466.0CXCL12, SERPINF1, TGFB2, VEGFA, THBS1, FGF2
41cysteine466.0VCAM1, ADM, ANGPT2, VTN, GAD1, CTGF
42glucose465.9AGT, CTGF, GAD1, ANGPT2, ADM, VCAM1
43genistein46 30 62 3 25 1210.9HIF1A, VEGFA, IGFBP1, IGF1, THBS1, TIMP3
44estrogen465.9IGF1, IGFBP1, VEGFA, HIF1A, TIMP3, TGFB2
45retinoic acid46 256.6ANGPT2, ICAM1, VTN, CTGF, FGF2, ADM
46serine465.6FGF2, THBS1, IGF1, IGFBP1, HIF1A, ANGPT2
47phosphatidylinositol465.1IGFBP1, IGF1, THBS1, VTN, ICAM1, ANGPT2
48dexamethasone46 52 30 127.7HIF1A, VEGFA, IGFBP1, IGF1, THBS1, CTGF
49vegf464.6VEGFA, HIF1A, TIMP3, SERPINF1, VCAM1, ADM
50tyrosine464.5THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2

GO Terms for genes affiliated with Diabetic Retinopathy

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Sources:
17Gene Ontology
See all sources

Cellular components related to Diabetic Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ICAM1, CXCL12, VCAM1, THBS1
2platelet alpha granule lumenGO:0310938.3THBS1, IGF1, VEGFA, TGFB2
3extracellular matrixGO:0310128.0THBS1, TIMP3, TGFB2, SERPINF1, VTN
4extracellular regionGO:0055765.7THBS1, IGF1, IGFBP1, VEGFA, TGFB2, SERPINF1
5extracellular spaceGO:0056155.1FGF2, THBS1, IGF1, IGFBP1, VEGFA, TGFB2

Biological processes related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idNameGO IDScoreTop Affiliating Genes
1cell adhesion mediated by integrinGO:03362710.3ICAM1, VTN
2positive regulation of axon extension involved in axon guidanceGO:04884210.3VEGFA, CXCL12
3membrane to membrane dockingGO:02261410.2VCAM1, ICAM1
4positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.1VEGFA, HIF1A
5organ regenerationGO:03110010.1ADM, CXCL12, ANGPT2
6positive regulation of smooth muscle cell migrationGO:01491110.0VTN, IGF1
7induction of positive chemotaxisGO:05093010.0CXCL12, VEGFA
8positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.9VEGFA, HIF1A, VTN
9positive regulation of cerebellar granule cell precursor proliferationGO:0219409.9IGF1, FGF2
10dopaminergic neuron differentiationGO:0715429.9VEGFA, HIF1A
11kidney developmentGO:0018229.8VEGFA, SERPINF1, AGT
12positive regulation of cardiac muscle hypertrophyGO:0106139.8IGF1, AGT
13cell-matrix adhesionGO:0071609.8AGT, CTGF, VTN
14lung developmentGO:0303249.8VEGFA, CTGF, FGF2
15positive regulation of glycolytic processGO:0458219.7IGF1, HIF1A
16chronic inflammatory responseGO:0025449.7VCAM1, THBS1
17negative regulation of endopeptidase activityGO:0109519.7AGT, VTN, SERPINF1, TIMP3
18cellular response to hypoxiaGO:0714569.7VEGFA, HIF1A, ICAM1
19response to glucoseGO:0097499.7CTGF, ANGPT2, THBS1
20response to mechanical stimulusGO:0096129.7ANGPT2, CXCL12, THBS1
21agingGO:0075689.6AGT, ADM, VCAM1, SERPINF1
22glial cell differentiationGO:0100019.6IGF1, FGF2
23positive regulation of endothelial cell migrationGO:0105959.6AGT, VEGFA, THBS1
24positive regulation of blood vessel endothelial cell migrationGO:0435369.6THBS1, VEGFA, FGF2
25negative regulation of blood vessel endothelial cell migrationGO:0435379.5FGF2, ANGPT2, THBS1
26cellular response to tumor necrosis factorGO:0713569.5ICAM1, VCAM1, THBS1
27outflow tract morphogenesisGO:0031519.5THBS1, VEGFA, HIF1A
28regulation of transforming growth factor beta2 productionGO:0329099.5TGFB2, HIF1A
29response to woundingGO:0096119.5TGFB2, ADM, CTGF
30cell migration involved in sprouting angiogenesisGO:0020429.5FGF2, VEGFA
31negative regulation of angiogenesisGO:0165259.4AGT, ANGPT2, SERPINF1, THBS1
32positive regulation of endothelial cell proliferationGO:0019389.3VEGFA, HIF1A, CXCL12, FGF2
33positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3IGF1, VEGFA, ICAM1, VTN, AGT
34positive regulation of cell divisionGO:0517819.3FGF2, TGFB2, VEGFA
35blood vessel remodelingGO:0019749.2IGF1, TGFB2, AGT
36positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.1IGF1, TGFB2, AGT
37cell adhesionGO:0071559.0THBS1, VCAM1, CXCL12, ICAM1, VTN
38angiogenesisGO:0015258.9VEGFA, HIF1A, TGFB2, ANGPT2, CTGF
39platelet degranulationGO:0025768.8THBS1, IGF1, VEGFA, TGFB2
40platelet activationGO:0301688.8TGFB2, VEGFA, IGF1, THBS1
41negative regulation of cell growthGO:0303088.7TGFB2, AGT, FGF2
42cell migrationGO:0164778.6THBS1, TGFB2, CTGF
43response to drugGO:0424938.6GAD1, ICAM1, TGFB2, THBS1
44positive regulation of angiogenesisGO:0457668.6THBS1, VEGFA, HIF1A, ADM, ANGPT2, FGF2
45blood coagulationGO:0075968.6THBS1, IGF1, VEGFA, TGFB2, ANGPT2
46negative regulation of cell proliferationGO:0082858.4IGF1, TGFB2, ADM, AGT, FGF2
47positive regulation of cell proliferationGO:0082848.4IGF1, VEGFA, TGFB2, ADM, CTGF, FGF2
48signal transductionGO:0071658.4IGF1, IGFBP1, HIF1A, ADM, CXCL12, ANGPT2
49response to hypoxiaGO:0016667.6ANGPT2, THBS1, VEGFA, HIF1A, TGFB2, VCAM1
50extracellular matrix organizationGO:0301987.6THBS1, TGFB2, VCAM1, ICAM1, VTN, AGT

Molecular functions related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix bindingGO:05084010.0VTN, VEGFA
2insulin-like growth factor bindingGO:00552010.0CTGF, IGFBP1
3fibronectin bindingGO:0019689.6CTGF, VEGFA, THBS1
4hormone activityGO:0051799.5AGT, ADM, IGF1
5chemoattractant activityGO:0420569.5FGF2, VEGFA
6fibroblast growth factor bindingGO:0171349.2THBS1, FGF2
7receptor bindingGO:0051029.1TGFB2, ADM, CXCL12, ANGPT2
8cytokine activityGO:0051258.9FGF2, TGFB2, VEGFA
9heparin bindingGO:0082018.8THBS1, VEGFA, VTN, CTGF, FGF2
10protein heterodimerization activityGO:0469828.7VEGFA, HIF1A, TGFB2, GAD1
11integrin bindingGO:0051788.5THBS1, IGF1, VCAM1, ICAM1, VTN, CTGF
12growth factor activityGO:0080837.7FGF2, IGF1, VEGFA, TGFB2, CXCL12, CTGF
13protein bindingGO:0055155.2TGFB2, TIMP3, HIF1A, VEGFA, IGF1, THBS1

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
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28ICD9CM
30IUPHAR
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