MCID: DBT011
MIFTS: 73

Diabetic Retinopathy malady

Eye diseases category

Summaries for Diabetic Retinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic retinopathy, ([ˌrɛtnˈɑpəθi]) is retinopathy (damage to the retina) caused by... more...

MalaCards: Diabetic Retinopathy, also known as retinal abnormality - diabetes-related, is related to proliferative diabetic retinopathy and diabetes mellitus. An important gene associated with Diabetic Retinopathy is VEGFA (vascular endothelial growth factor A), and among its related pathways are Signaling by GPCR and Rho Family GTPases. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and retina, and related mouse phenotypes are mortality/aging and cellular.

Aliases & Classifications for Diabetic Retinopathy

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

diabetic retinopathy 8 22 10 44 30 60
retinal abnormality - diabetes-related 8
diabetic retinopathy nos 8


External Ids:

Disease Ontology8 DOID:8947
MeSH34 D003930
NCIt39 C34538
ICD9CM27 362.0
ICD1025 H36.0

Related Diseases for Diabetic Retinopathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative diabetic retinopathy32.0TGFB2, ADM, VTN, SERPINF1, VCAM1, THBS1
2diabetes mellitus31.3VTN, VCAM1, IGF1, IGFBP1, ANGPT2, VEGFA
3diabetic macular edema31.2SERPINF1, VEGFA
4type 2 diabetes mellitus31.0ADM, VCAM1, IGF1, IGFBP1, AGT, GAD1
5diabetic nephropathy30.9ADM, SERPINF1, THBS1, AGT, FLT1, CTGF
6retinal detachment30.9TGFB2, SERPINF1, VEGFA
7proliferative vitreoretinopathy30.9TGFB2, ADM, VTN, THBS1, FGF2, CTGF
8glaucoma30.9TGFB2, SERPINF1, CTGF
9neovascular glaucoma30.7VEGFA
10cataract30.7TGFB2, SERPINF1, CTGF
11ischemia30.6TGFB2, ADM, VTN, CXCL12, FGF2, HIF1A
12age related macular degeneration30.6VEGFA, FLT1, TIMP3
13leukostasis30.5VCAM1, ICAM1
14retinal ischemia30.5HIF1A, VEGFA
15atherosclerosis30.4VTN, SERPINF1, VCAM1, THBS1, CXCL12, FGF2
16hyperglycemia30.4VTN, SERPINF1, VCAM1, HIF1A, IGF1, IGFBP1
17proteinuria30.4ADM, VTN, ANGPT2, VEGFA, AGT, FLT1
18hypertension30.4ADM, VCAM1, IGF1, AGT, ICAM1
19macular holes30.4TGFB2, ADM, SERPINF1, ANGPT2
20macular retinal edema30.4SERPINF1, CXCL12, VEGFA
21retinal disease30.3ADM, SERPINF1, VCAM1, FGF2, HIF1A, IGF1
22obesity30.3THBS1, HIF1A, IGF1, IGFBP1, AGT, FLT1
23eye disease30.3TGFB2, SERPINF1, IGFBP1
24retinal vein occlusion30.3VEGFA
25leukemia30.2SERPINF1, CXCL12, FGF2, IGFBP1, ANGPT2, NRP1
26vascular disease30.2VTN, VCAM1, FGF2, ANGPT2, VEGFA, AGT
27myocardial infarction30.2ADM, CXCL12, HIF1A, IGFBP1, AGT, CTGF
28coronary artery disease30.2VTN, VCAM1, HIF1A, IGFBP1, AGT, ICAM1
29uveitis30.2TGFB2, SERPINF1, ICAM1
30acromegaly30.2IGF1, IGFBP1
31osteoarthritis29.9TGFB2, VCAM1, THBS1, CXCL12, FGF2, IGF1
32hypoglycemia29.9HIF1A, IGF1, IGFBP1, GAD1
33vascular cancer29.9THBS1, FGF2, VEGFA, FLT1
34stroke, ischemic29.9ADM, VCAM1, ICAM1
35retinal vascular disease29.9SERPINF1, VEGFA, CTGF
36pre-eclampsia29.9FLT1
37nephrosclerosis29.9ADM
38acute leukemia29.9CXCL12
39severe pre-eclampsia29.9VCAM1, IGFBP1
40hypothyroidism29.9IGF1
41retinitis11.0
42background diabetic retinopathy10.6
43severe nonproliferative diabetic retinopathy10.6
44type 1 diabetes mellitus10.5
45diabetic cataract10.5
46vitreous detachment10.5
47neuronitis10.4
48diabetic neuropathy10.4
49neuropathy10.4
50choroiditis10.4

Graphical network of the top 20 diseases related to Diabetic Retinopathy:



Diseases related to diabetic retinopathy

Clinical Features for Diabetic Retinopathy

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Drugs & Therapeutics for Diabetic Retinopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Retinopathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Retinopathy

Search NIH Clinical Center for Diabetic Retinopathy

Search CenterWatch for Diabetic Retinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Retinopathy cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Retinopathy

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22GTR
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Genetic tests related to Diabetic Retinopathy:

id Genetic test Affiliating Genes
1 Diabetic Retinopathy22

Anatomical Context for Diabetic Retinopathy

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Diabetic Retinopathy:

32
Endothelial, Eye, Retina, Bone, Monocytes, Heart, Testes, Kidney, Myeloid, Placenta, Thyroid, Ovary, T cells, Liver, Tongue, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Retinopathy:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeInner Nuclear LayerMature Muller Glia Cells Affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease

Animal Models for Diabetic Retinopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Retinopathy:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.3AGT, NRP1, FLT1, GAD1, CTGF, ICAM1
2MP:000538412.3VEGFA, NRP1, FLT1, GAD1, CTGF, ICAM1
3MP:000538712.2VEGFA, AGT, NRP1, FLT1, ICAM1, TIMP3
4MP:000537811.9FLT1, GAD1, CTGF, ICAM1, TIMP3, NRP1
5MP:000538511.9TGFB2, CTGF, FLT1, NRP1, AGT, ANGPT2
6MP:000539711.7TIMP3, ICAM1, FLT1, VEGFA, IGF1, HIF1A
7MP:000536911.6ICAM1, FLT1, AGT, IGF1, HIF1A, FGF2
8MP:000537611.6TIMP3, ICAM1, CTGF, GAD1, AGT, IGF1
9MP:000538111.6ICAM1, CTGF, GAD1, VEGFA, ANGPT2, HIF1A
10MP:000538811.5TIMP3, CTGF, GAD1, VEGFA, IGF1, HIF1A
11MP:000539111.4TIMP3, ANGPT2, HIF1A, FGF2, THBS1, SERPINF1
12MP:000537011.4TIMP3, AGT, VEGFA, IGFBP1, HIF1A, CXCL12
13MP:000538911.2FLT1, VEGFA, THBS1, SERPINF1, TGFB2
14MP:000536711.1TIMP3, AGT, HIF1A, THBS1, ADM, TGFB2
15MP:000287311.1CTGF, GAD1, FLT1, VEGFA, IGF1, HIF1A
16MP:001077111.1TIMP3, CTGF, VEGFA, ANGPT2, HIF1A
17MP:000363111.1GAD1, NRP1, AGT, SERPINF1
18MP:000538211.0TGFB2, HIF1A, VEGFA, NRP1, GAD1, CTGF
19MP:000538011.0CTGF, GAD1, VCAM1, ADM, TGFB2
20MP:000539010.9CTGF, VEGFA, IGF1, FGF2, TGFB2
21MP:000537910.8SERPINF1, ICAM1
22MP:000200610.4ICAM1, IGF1, THBS1

Publications for Diabetic Retinopathy

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50PubMed
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Articles related to Diabetic Retinopathy:

(show top 50)    (show all 1728)
idTitleAuthorsYear
1
An effective programme to systematic diabetic retinopathy screening in order to reduce diabetic retinopathy blindness. (24392466)
2014
2
Refining the treatment parameters of diabetic retinopathy: New prospects and limitations on the horizon. (24360342)
2013
3
Decision support system for diabetic retinopathy using discrete wavelet transform. (23662341)
2013
4
Verification of multimarkers for detection of early stage diabetic retinopathy using multiple reaction monitoring. (23368427)
2013
5
Serum total bilirubin levels and prevalence of diabetic retinopathy in Chinese population. (24034422)
2013
6
Diabetic retinopathy and microalbuminuria can predict macroalbuminuria and renal function decline in Japanese type 2 diabetic patients: Japan Diabetes Complications Study. (23620478)
2013
7
Mean platelet volume measurement protocol should be standardized for diabetic retinopathy. (24126679)
2013
8
Subfoveal choroidal thickness in diabetes and diabetic retinopathy. (23697958)
2013
9
Receptor for advanced glycation end-product (RAGE) gene polymorphism 2245G/A is associated with pro-inflammatory, oxidative-glycation markers and sRAGE in diabetic retinopathy. (23545311)
2013
10
Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy: An In Vivo Study Using Spectral Domain OCT. (24386645)
2013
11
Therapeutic implications of curcumin in the prevention of diabetic retinopathy via modulation of anti-oxidant activity and genetic pathways. (24379904)
2013
12
Microaneurysm turnover at the macula predicts risk of development of clinically significant macular edema in persons with mild nonproliferative diabetic retinopathy. (23204247)
2013
13
Inner retinal visual dysfunction is a sensitive marker of non-proliferative diabetic retinopathy. (22174096)
2012
14
Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy. (22180072)
2011
15
Ophthalmodynamometric pressure in eyes with proliferative diabetic retinopathy measured during pars plana vitrectomy. (21236404)
2011
16
Osteopoikilosis in a diabetic patient complicated with adhesive capsulitis and retinopathy. (21841740)
2011
17
High levels of serum prolactin protect against diabetic retinopathy by increasing ocular vasoinhibins. (20823101)
2010
18
Entry site treatment to prevent late recurrent postoperative vitreous cavity haemorrhage after vitrectomy for proliferative diabetic retinopathy. (19955203)
2010
19
Masked hypertension, nocturnal blood pressure and retinopathy in normotensive patients with type 1 diabetes. (19926157)
2010
20
Retinopathy and nephropathy in type 1 diabetic patients--association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes. (20120526)
2009
21
Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy. (19107135)
2009
22
Vascular endothelial growth factor-A (VEGF-A) in vitreous fluid of patients with proliferative diabetic retinopathy. (20214050)
2009
23
Expression of integrins in human proliferative diabetic retinopathy membranes. (19020635)
2008
24
Intravitreal bevacizumab (Avastin) in proliferative diabetic retinopathy. (17995986)
2008
25
Use of long-acting somatostatin analogue treatment in diabetic retinopathy. (17245082)
2007
26
Contribution of selected cellular adhesion molecules and proinflammatory cytokines in the pathogenesis of proliferative diabetic retinopathy]. (18159844)
2007
27
Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. (16936187)
2006
28
Aqueous levels of macrophage migration inhibitory factor and monocyte chemotactic protein-1 in patients with diabetic retinopathy. (15569131)
2004
29
Inhibition of protein kinase C might be harmful to diabetic retinopathy. (15193366)
2004
30
Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. (14988276)
2004
31
Genetics of diabetic complications: retinopathy]. (15163920)
2004
32
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. (12592403)
2003
33
Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. (12540964)
2003
34
Intravitreal triamcinolone acetonide as an additional tool in pars plana vitrectomy for proliferative diabetic retinopathy. (12841570)
2003
35
Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. (11849464)
2002
36
Genes and diabetic retinopathy. (12090088)
2002
37
Contents of T-lymphocytes and expression of intercellular adhesion molecule ICAM-1 in the retina and choroid in diabetic retinopathy]. (11765468)
2001
38
Effect of retinal coagulation status on oxidative metabolite and VEGF in 208 patients with proliferative diabetic retinopathy]. (11258131)
2001
39
Serum laminin as a marker of diabetic retinopathy development: a 4-year follow-up study. (10704551)
2000
40
Type 1 diabetes: long-term effects of intensive insulin therapy on diabetic retinopathy and nephropathy]. (10776417)
2000
41
Increased vitreous concentrations of human hepatocyte growth factor in proliferative diabetic retinopathy. (10022434)
1999
42
Acute phase serum proteins in diabetic retinopathy. (8916594)
1996
43
Factors related to the development and progression of diabetic retinopathy in patients with type 2 diabetes. (8737232)
1996
44
Spontaneous regression of neovascularization at the disk and elsewhere in diabetic retinopathy. (8862045)
1996
45
Outlook for the future in the treatment of diabetic retinopathy]. (7528151)
1994
46
The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate. (1923364)
1991
47
Contrast sensitivity changes in background diabetic retinopathy. (2013027)
1991
48
The effects of an aldose reductase inhibitor on the progression of diabetic retinopathy. (1790735)
1991
49
Asymmetric proliferative diabetic retinopathy and carotid artery disease. (2381700)
1990
50
A Chinese family with Wolfram syndrome presenting with rapidly progressing diabetic retinopathy and renal failure. (2221817)
1990

Genetic Variations for Diabetic Retinopathy

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Expression for genes affiliated with Diabetic Retinopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Retinopathy

Search GEO for disease gene expression data for Diabetic Retinopathy.

Pathways for genes affiliated with Diabetic Retinopathy

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 12EMD Millipore
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Pathways related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6ICAM1, FLT1, NRP1, AGT, VEGFA, IGF1
2
Hide members
11.4TIMP3, CTGF, FLT1, NRP1, ANGPT2, IGF1
311.2TIMP3, VEGFA, IGF1, HIF1A, FGF2, THBS1
4
Hide members
11.2TIMP3, CTGF, FLT1, ANGPT2, IGF1, FGF2
511.1FLT1, VEGFA, ANGPT2, IGF1, FGF2, THBS1
6
Hide members
11.1TIMP3, CTGF, FLT1, NRP1, ANGPT2, IGF1
7
Hide members
11.1TIMP3, CTGF, FLT1, NRP1, FGF2, CXCL12
8
Hide members
11.1TIMP3, CTGF, FLT1, IGF1, FGF2, CXCL12
9
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11.1TIMP3, CTGF, FLT1, NRP1, IGF1, FGF2
10
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11.0TIMP3, CTGF, FLT1, NRP1, IGF1, FGF2
1110.9VEGFA, IGFBP1, HIF1A, CXCL12, ADM
12
Hide members
10.9ICAM1, CXCL12, THBS1, VCAM1, VTN
1310.9FLT1, VEGFA, ANGPT2, IGF1, HIF1A
14
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10.9ANGPT2, AGT, FLT1, CTGF, TIMP3
15
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10.9FLT1, VEGFA, IGF1, THBS1, VTN
1610.9TIMP3, FLT1, VEGFA, HIF1A, FGF2
1710.9TIMP3, FLT1, ANGPT2, HIF1A, FGF2
18
Hide members
10.9TIMP3, FLT1, NRP1, VEGFA, FGF2
19
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10.9TIMP3, CTGF, FLT1, NRP1, FGF2
20
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10.8ICAM1, FGF2, VCAM1, VTN
21
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10.8ICAM1, NRP1, VEGFA, VCAM1
22
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10.8TIMP3, CTGF, IGF1, CXCL12
2310.8VEGFA, IGF1, FGF2, THBS1
24
Hide members
10.8FLT1, NRP1, VEGFA, HIF1A
25
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10.8CTGF, FLT1, NRP1, CXCL12
26
Cell adhesion ECM remodeling
Hide members
10.8VTN, IGF1, TIMP3
2710.8VCAM1, CXCL12, ICAM1
2810.7ICAM1, CTGF, VTN
2910.7IGF1, VEGFA, FLT1
30
Hide members
10.7AGT, NRP1, TIMP3
31
Hide members
10.7VEGFA, NRP1, FLT1
3210.7FGF2, CXCL12, THBS1
3310.7VTN, VEGFA
3410.7IGF1, TIMP3
35
Hide members
10.7THBS1, VEGFA
3610.7FGF2, HIF1A
37
Hide members
10.6IGF1
3810.6FLT1
3910.6NRP1

Compounds for genes affiliated with Diabetic Retinopathy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.6TIMP3, ICAM1, CTGF, GAD1, FLT1, NRP1
2vegf4412.6TIMP3, ICAM1, FLT1, NRP1, AGT, VEGFA
3phosphatidylinositol4412.5VTN, ADM, TGFB2, VCAM1, THBS1, TIMP3
4nitric oxide44 11 2414.2ICAM1, CTGF, GAD1, FLT1, NRP1, AGT
5cysteine4412.2TIMP3, CTGF, GAD1, NRP1, AGT, ANGPT2
6retinoic acid44 2413.1ICAM1, IGF1, IGFBP1, ANGPT2, CTGF, TIMP3
7glucose4412.1FLT1, NRP1, AGT, ANGPT2, IGF1, HIF1A
8genistein44 28 59 2 11 2417.1TGFB2, VCAM1, THBS1, CXCL12, ICAM1, FLT1
9thymidine44 2413.0HIF1A, FGF2, CXCL12, THBS1, ADM, TGFB2
10ly2940024411.9TIMP3, ICAM1, CTGF, AGT, VEGFA, ANGPT2
11wortmannin4411.9ADM, VTN, TIMP3, NRP1, AGT, ANGPT2
12pd 98,0594411.9THBS1, VCAM1, VTN, CXCL12, FGF2, TIMP3
13dexamethasone44 49 28 1114.9VEGFA, ANGPT2, AGT, CTGF, TIMP3, HIF1A
14sb 20358044 5912.9ICAM1, CTGF, FLT1, AGT, VEGFA, IGF1
15paraffin4411.9TIMP3, ANGPT2, FLT1, AGT, VEGFA, FGF2
16heparin44 28 11 2414.8TIMP3, CTGF, FLT1, NRP1, AGT, VEGFA
17h2o24411.8ADM, SERPINF1, ICAM1, CTGF, GAD1, FLT1
18prostacyclin4411.8ICAM1, CTGF, FLT1, AGT, VEGFA, FGF2
19cholesterol44 28 11 2414.8IGF1, CXCL12, THBS1, VCAM1, VTN, ADM
20arginine4411.8ADM, VCAM1, CXCL12, HIF1A, IGF1, IGFBP1
21calcium44 49 11 2414.8NRP1, TGFB2, IGFBP1, ANGPT2, CXCL12, SERPINF1
22ribonucleic acid4411.8IGF1, IGFBP1, ANGPT2, CXCL12, NRP1, CTGF
23oxygen44 2412.7TIMP3, ICAM1, GAD1, FLT1, AGT, ANGPT2
24hyaluronic acid44 2412.7THBS1, CXCL12, FGF2, VEGFA, NRP1, VCAM1
25lipid4411.7TIMP3, ADM, VTN, FLT1, VCAM1, NRP1
26cyclosporin a44 28 5913.6ICAM1, HIF1A, TGFB2, ADM, THBS1, FGF2
27fibrinogen4411.6THBS1, ICAM1, CTGF, AGT, IGFBP1, ANGPT2
28rapamycin4411.6CXCL12, THBS1, HIF1A, IGFBP1, VEGFA, AGT
29actinomycin d4411.6VEGFA, ADM, ICAM1, AGT, IGFBP1, IGF1
30steroid4411.6NRP1, TGFB2, ADM, CXCL12, IGFBP1, ANGPT2
31glycosaminoglycan4411.6THBS1, FGF2, TIMP3, CXCL12, TGFB2, VTN
32cytochalasin d44 5912.6THBS1, VTN, VCAM1, FGF2, CTGF, ICAM1
33matrigel4411.6NRP1, HIF1A, CXCL12, THBS1, VTN, TGFB2
34progesterone44 59 28 11 2415.5FLT1, TIMP3, GAD1, TGFB2, ADM, THBS1
35n acetylcysteine4411.5ICAM1, TGFB2, SERPINF1, VCAM1, HIF1A, VEGFA
36serine4411.5VTN, FLT1, SERPINF1, THBS1, FGF2, AGT
37tamoxifen44 49 28 1114.4IGFBP1, VCAM1, VTN, THBS1, CXCL12, IGF1
38tgf beta14411.4CTGF, FLT1, THBS1, FGF2, VCAM1, TGFB2
39creatinine4411.4TGFB2, GAD1, FLT1, AGT, IGF1, ANGPT2
40alanine4411.3VCAM1, VTN, IGFBP1, THBS1, FGF2, NRP1
41guanylate4411.2SERPINF1, ANGPT2, NRP1, FLT1, ADM, AGT
42pge24411.1VEGFA, VTN
43cycloheximide4411.0CXCL12, IGFBP1
44hydrocortisone44 2 59 1114.0ADM, IGFBP1, FGF2, FLT1, IGF1
45estradiol44 11 2413.0TGFB2, TIMP3, GAD1
46diphenyleneiodonium4411.0SERPINF1, VCAM1
47l-nmma4410.9ADM, AGT, VCAM1, HIF1A, IGF1
48herbimycin a44 5911.9IGFBP1, FGF2, CXCL12, VCAM1, VTN, ICAM1
49mannitol44 1111.7ICAM1
50cobalt chloride4410.5VEGFA, HIF1A, VCAM1, ADM

GO Terms for genes affiliated with Diabetic Retinopathy

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Sources:
16Gene Ontology
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Cellular components related to Diabetic Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561512.0TGFB2, ICAM1, CTGF, FLT1, AGT, VEGFA
2extracellular regionGO:00557611.7IGFBP1, ANGPT2, VEGFA, AGT, NRP1, CTGF
3external side of plasma membraneGO:00989710.8VCAM1, THBS1, CXCL12, ICAM1
4platelet alpha granule lumenGO:03109310.7VEGFA, IGF1, THBS1, TGFB2
5extracellular matrixGO:03101210.6TIMP3, THBS1, SERPINF1, VTN, TGFB2

Biological processes related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.6HIF1A, IGFBP1, CXCL12, IGF1, ADM, ANGPT2
2response to hypoxiaGO:00166611.6HIF1A, ANGPT2, VEGFA, VCAM1, ADM, TGFB2
3positive regulation of angiogenesisGO:04576611.6FLT1, ADM, THBS1, ANGPT2, HIF1A, VEGFA
4positive regulation of cell proliferationGO:00828411.6CTGF, VEGFA, IGF1, FGF2, ADM, TGFB2
5cell adhesionGO:00715511.4VTN, VCAM1, THBS1, ICAM1, NRP1, CXCL12
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.4VTN, VEGFA, AGT, NRP1, IGF1
7angiogenesisGO:00152511.3ANGPT2, TGFB2, CTGF, HIF1A, VEGFA
8extracellular matrix organizationGO:03019811.3THBS1, TGFB2, FGF2, AGT, VTN
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094911.3HIF1A, VEGFA, FLT1, VTN
10positive regulation of endothelial cell migrationGO:01059511.3THBS1, VEGFA, AGT, NRP1
11patterning of blood vesselsGO:00156911.3NRP1, VEGFA, CXCL12, FLT1
12negative regulation of cell proliferationGO:00828511.3ADM, IGF1, FGF2, TGFB2, AGT
13positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.3FLT1, AGT, TGFB2, IGF1
14response to woundingGO:00961111.3CTGF, NRP1, ADM, TGFB2
15positive regulation of endothelial cell proliferationGO:00193811.3HIF1A, FGF2, VEGFA, NRP1
16platelet degranulationGO:00257611.2THBS1, TGFB2, VEGFA, IGF1
17cell migrationGO:01647711.2THBS1, TGFB2, CTGF, FLT1
18heart developmentGO:00750711.2NRP1, VCAM1, ADM, TGFB2
19positive regulation of smooth muscle cell migrationGO:01491111.2VTN, IGF1, NRP1
20negative regulation of blood vessel endothelial cell migrationGO:04353711.2ANGPT2, FGF2, THBS1
21positive regulation of blood vessel endothelial cell migrationGO:04353611.2VEGFA, FGF2, THBS1
22vascular endothelial growth factor receptor signaling pathwayGO:04801011.1FLT1, NRP1, VEGFA
23positive chemotaxisGO:05091811.1FGF2, VEGFA, NRP1
24blood vessel remodelingGO:00197411.1AGT, IGF1, TGFB2
25outflow tract morphogenesisGO:00315111.1THBS1, HIF1A, VEGFA
26blood coagulationGO:00759611.1TGFB2, VEGFA, ANGPT2, IGF1, THBS1
27positive regulation of cell divisionGO:05178111.1VEGFA, FGF2, TGFB2
28positive regulation of retinal ganglion cell axon guidanceGO:190233611.0VEGFA, NRP1
29regulation of retinal ganglion cell axon guidanceGO:09025911.0NRP1, VEGFA
30negative regulation of angiogenesisGO:01652511.0ANGPT2, SERPINF1, THBS1
31platelet activationGO:03016811.0IGF1, VEGFA, THBS1, TGFB2
32positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141911.0HIF1A, VEGFA
33positive regulation of axon extension involved in axon guidanceGO:04884211.0VEGFA, NRP1
34positive regulation of cerebellar granule cell precursor proliferationGO:02194011.0IGF1, FGF2
35response to glucose stimulusGO:00974911.0ANGPT2, CTGF, THBS1
36regulation of transforming growth factor beta2 productionGO:03290911.0HIF1A, TGFB2
37positive regulation of MAPK cascadeGO:04341011.0IGF1, FLT1, AGT
38membrane to membrane dockingGO:02261411.0VCAM1, ICAM1
39negative regulation of endopeptidase activityGO:01095111.0AGT, SERPINF1, VTN
40embryonic morphogenesisGO:04859811.0FGF2, FLT1
41cell adhesion mediated by integrinGO:03362711.0ICAM1, VTN
42endothelial cell chemotaxisGO:03576710.9VEGFA, NRP1
43commissural neuron axon guidanceGO:07167910.9NRP1, VEGFA
44cell-matrix adhesionGO:00716010.9CTGF, AGT, VTN
45cell-cell signalingGO:00726710.8NRP1, AGT, ADM, TGFB2
46positive regulation of phospholipase C activityGO:01086310.8FLT1, FGF2
47chronic inflammatory responseGO:00254410.7VCAM1, THBS1
48positive regulation of cardiac muscle hypertrophyGO:01061310.7IGF1, AGT
49lung developmentGO:03032410.6FGF2, VEGFA, CTGF
50cellular response to hypoxiaGO:07145610.5ICAM1, VEGFA, HIF1A

Molecular functions related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.0AGT, NRP1, FLT1, GAD1, CTGF, ICAM1
2growth factor activityGO:00808311.3TGFB2, CTGF, AGT, VEGFA, IGF1, FGF2
3integrin bindingGO:00517811.2ICAM1, CTGF, IGF1, THBS1, VCAM1, VTN
4heparin bindingGO:00820111.1CTGF, NRP1, VEGFA, FGF2, THBS1, VTN
5fibronectin bindingGO:00196810.8CTGF, VEGFA, THBS1
6hormone activityGO:00517910.7ADM, IGF1, AGT
7vascular endothelial growth factor-activated receptor activityGO:00502110.6NRP1, FLT1
8receptor bindingGO:00510210.5ANGPT2, CXCL12, ADM, TGFB2

Products for genes affiliated with Diabetic Retinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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50PubMed
51QIAGEN
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60UMLS
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