MCID: DBT011
MIFTS: 71

Diabetic Retinopathy malady

Eye diseases category
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Summaries for Diabetic Retinopathy

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Wikipedia:65 Diabetic retinopathy, ([?r?tn??p??i]) is retinopathy (damage to the retina) caused by complications of... more...

MalaCards based summary: Diabetic Retinopathy, also known as retinal abnormality - diabetes-related, is related to diabetic macular edema and neovascular glaucoma. An important gene associated with Diabetic Retinopathy is VEGFA (vascular endothelial growth factor A), and among its related pathways are LDL Oxidation in Atherogenesis and amb2 Integrin signaling. The compounds cobalt chloride and diphenyleneiodonium have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and retina, and related mouse phenotypes are normal and liver/biliary system.

Aliases & Classifications for Diabetic Retinopathy

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Diabetic Retinopathy, Aliases & Descriptions:

Name: Diabetic Retinopathy 30 8 22 10 44 62
 
Retinal Abnormality - Diabetes-Related 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:8947
ICD9CM27 362.0
NCIt39 C34538
MeSH34 D003930
ICD1025 H36.0

Related Diseases for Diabetic Retinopathy

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Diseases related to Diabetic Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic macular edema31.8SERPINF1, VEGFA
2neovascular glaucoma31.7VEGFA
3proliferative vitreoretinopathy31.4TGFB2
4age related macular degeneration31.4TIMP3, VEGFA
5blindness31.3SERPINF1, TIMP3, VEGFA
6retinal detachment31.2SERPINF1, TGFB2, VEGFA
7leukostasis31.2ICAM1, VCAM1
8retinal vein occlusion31.1VEGFA
9retinal ischemia31.0HIF1A, VEGFA
10cataract30.9CTGF, SERPINF1, TGFB2
11central retinal vein occlusion30.8VEGFA
12type 1 diabetes mellitus30.7AGT, GAD1, IGFBP1, IGF1
13type 2 diabetes mellitus30.7AGT, GAD1, ADM, VCAM1, IGFBP1, IGF1
14macular holes30.6ANGPT2, ADM, SERPINF1, TGFB2
15laron syndrome30.5IGFBP1, IGF1
16diabetic nephropathy30.5AGT, CTGF, ADM, SERPINF1, TIMP3, THBS1
17proteinuria30.5AGT, CTGF, VTN, ANGPT2, ADM, VEGFA
18diabetes mellitus30.4AGT, CTGF, GAD1, VTN, ICAM1, ANGPT2
19hypertension30.4AGT, ICAM1, ADM, VCAM1, IGF1
20uveitis30.4ICAM1, SERPINF1, TGFB2
21retinal degeneration30.3FGF2, SERPINF1, TIMP3
22insulin resistance30.3AGT, CTGF, VCAM1, IGFBP1, IGF1
23leukemia30.0FGF2, ICAM1, ANGPT2, CXCL12, SERPINF1, IGFBP1
24hypoglycemia30.0GAD1, HIF1A, IGFBP1, IGF1
25myocardial infarction29.9AGT, CTGF, CXCL12, ADM, HIF1A, IGFBP1
26obesity29.9AGT, HIF1A, IGFBP1, IGF1, THBS1
27hyperglycemia29.6AGT, CTGF, GAD1, VTN, VCAM1, SERPINF1
28pre-eclampsia29.4AGT, ICAM1, ANGPT2, ADM, VCAM1, HIF1A
29proliferative diabetic retinopathy28.9FGF2, AGT, CTGF, GAD1, VTN, ICAM1
30atherosclerosis28.8FGF2, AGT, CTGF, VTN, ICAM1, ANGPT2
31ischemia28.8FGF2, AGT, CTGF, GAD1, VTN, ICAM1
32osteoarthritis28.6FGF2, CTGF, ANGPT2, CXCL12, VCAM1, TGFB2
33retinitis11.1
34endotheliitis11.1
35background diabetic retinopathy10.6
36malaria10.6ICAM1
37severe nonproliferative diabetic retinopathy10.5
38neuronitis10.5
39neuropathy10.5
40vitreous detachment10.4
41acute chest syndrome10.4VCAM1
42retinopathy of prematurity10.4VEGFA, IGF1
43placental insufficiency10.4ANGPT2, IGFBP1
44choroiditis10.4
45mild pre-eclampsia10.4VCAM1, IGFBP1
46retinal vascular disease10.4CTGF, SERPINF1, VEGFA
47macular retinal edema10.4CXCL12, SERPINF1, VEGFA
48craniopharyngioma10.4IGF1
49arteriosclerosis obliterans10.4ICAM1, VCAM1
50immunoglobulin a vasculitis10.4ICAM1, VCAM1

Graphical network of the top 20 diseases related to Diabetic Retinopathy:



Diseases related to diabetic retinopathy

Symptoms for Diabetic Retinopathy

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Drugs & Therapeutics for Diabetic Retinopathy

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Drug clinical trials:

Search ClinicalTrials for Diabetic Retinopathy

Search NIH Clinical Center for Diabetic Retinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Retinopathy cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Retinopathy

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Genetic tests related to Diabetic Retinopathy:

id Genetic test Affiliating Genes
1 Diabetic Retinopathy22

Anatomical Context for Diabetic Retinopathy

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MalaCards organs/tissues related to Diabetic Retinopathy:

32
Endothelial, Eye, Retina, Bone, Monocytes, Testes, Heart, Kidney, Neutrophil, Placenta, Liver, Thyroid, Myeloid, T cells, Tongue, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Retinopathy:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeInner Nuclear LayerMature Muller Glia Cells Affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease

Animal Models for Diabetic Retinopathy or affiliated genes

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MGI Mouse Phenotypes related to Diabetic Retinopathy:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1VEGFA, HIF1A, CXCL12, VTN, GAD1, CTGF
2MP:00053707.8THBS1, IGFBP1, VEGFA, HIF1A, TIMP3, ADM
3MP:00020067.8THBS1, IGF1, VEGFA, HIF1A, ICAM1, FGF2
4MP:00107717.6THBS1, IGF1, VEGFA, HIF1A, TIMP3, ADM
5MP:00053807.4VEGFA, HIF1A, TGFB2, VCAM1, ADM, GAD1
6MP:00053717.4THBS1, IGF1, VEGFA, HIF1A, TGFB2, GAD1
7MP:00053817.2THBS1, VEGFA, HIF1A, TGFB2, SERPINF1, ANGPT2
8MP:00053677.1THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
9MP:00053797.0THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
10MP:00053886.8THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
11MP:00053916.8TIMP3, HIF1A, VEGFA, THBS1, TGFB2, SERPINF1
12MP:00053906.7THBS1, IGF1, VEGFA, HIF1A, TGFB2, GAD1
13MP:00053896.6THBS1, IGF1, VEGFA, TGFB2, SERPINF1, VCAM1
14MP:00036316.4IGF1, VEGFA, HIF1A, TGFB2, SERPINF1, CXCL12
15MP:00053696.1THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
16MP:00053786.0THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
17MP:00053975.9TIMP3, HIF1A, VEGFA, IGF1, THBS1, TGFB2
18MP:00053875.8HIF1A, VEGFA, IGFBP1, IGF1, THBS1, TIMP3
19MP:00053845.7HIF1A, VEGFA, IGFBP1, IGF1, THBS1, TIMP3
20MP:00053855.1FGF2, THBS1, IGF1, VEGFA, HIF1A, TIMP3
21MP:00053765.0TGFB2, TIMP3, HIF1A, VEGFA, IGF1, THBS1
22MP:00107684.9TGFB2, TIMP3, HIF1A, VEGFA, IGF1, THBS1

Publications for Diabetic Retinopathy

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Articles related to Diabetic Retinopathy:

(show top 50)    (show all 1546)
idTitleAuthorsYear
1
Suppression of protein kinase C-IP attenuates vascular leakage via prevention of tight junction protein decrease in diabetic retinopathy. (24434146)
2014
2
Relationship of Diabetic Retinopathy with Coronary Artery Disease in Asian Indians with Type 2 Diabetes: The Chennai Urban Rural Epidemiology Study (CURES) Eye Study-3. (25375662)
2014
3
Association study of sorbitol dehydrogenase -888G>C polymorphism with type 2 diabetic retinopathy in Caucasian-Brazilians. (23850972)
2013
4
Plasma kallikrein-kinin system and diabetic retinopathy. (23362193)
2013
5
Mitochondria damage in the pathogenesis of diabetic retinopathy and in the metabolic memory associated with its continued progression. (23745551)
2013
6
Screening intervals for diabetic retinopathy and incidence of visual loss: a systematic review. (23819487)
2013
7
Enzymatic vitrectomy for diabetic retinopathy and diabetic macular edema. (24379923)
2013
8
Editorial: possible therapeutic targets for the treatment of diabetic retinopathy: evidences from experimental models. (23173955)
2013
9
Association of angiotensin-converting enzyme gene 2350 G/A polymorphism with diabetic retinopathy in Chinese Han population. (23065222)
2013
10
Aldo-keto reductase and sorbitol dehydrogenase enzymes in Egyptian diabetic patients with and without proliferative diabetic retinopathy. (23452182)
2013
11
Assessing the Need for Referral in Automatic Diabetic Retinopathy Detection. (23963192)
2013
12
Susceptibility genes, HLA and diabetic retinopathy in the Algerian population]. (22981956)
2013
13
Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy. (23037145)
2013
14
Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. (23633659)
2013
15
Improving the uptake of screening for diabetic retinopathy. (23373479)
2013
16
Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy. (23891690)
2013
17
Diabetes, diabetic retinopathy, and age-related macular degeneration: an unexpected relationship. (23470781)
2013
18
Relationship between diabetic retinopathy, microalbuminuria and overt nephropathy, and twenty-year incidence follow-up of a sample of type 1 diabetic patients. (22921286)
2012
19
Serum lipids and diabetic retinopathy: A cross-sectional study. (23565476)
2012
20
PEDF in diabetic retinopathy: a protective effect of oxidative stress. (22570532)
2012
21
Cysteine-rich 61 (CYR61) is up-regulated in proliferative diabetic retinopathy. (22160564)
2012
22
Plasma, aqueous and vitreous homocysteine levels in proliferative diabetic retinopathy. (22353698)
2012
23
Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy. (22180072)
2011
24
Intraocular expression of serum amyloid a and interleukin-6 in proliferative diabetic retinopathy. (21704966)
2011
25
Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy. (22125532)
2011
26
Diabetic retinopathy: An update on treatment. (20193825)
2010
27
Plasma and aqueous humor angiotensin-converting enzyme levels in patients with diabetic retinopathy. (20373882)
2010
28
Anti-VEGF therapy in proliferative diabetic retinopathy. (19349790)
2009
29
Diabetic retinopathy is not associated with carbonic anhydrase gene polymorphisms. (19536309)
2009
30
Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. (19404486)
2009
31
Morphologic changes in the anterior segment after phacovitrectomy for proliferative diabetic retinopathy. (19393886)
2009
32
Increased levels of monokine induced by interferon-gamma (Mig) in the vitreous of patients with diabetic retinopathy. (18644076)
2008
33
The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy. (18436850)
2008
34
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. (17653050)
2007
35
Endothelin antagonism prevents diabetic retinopathy in NOD mice: a potential role of the angiogenic factor adrenomedullin. (16741057)
2006
36
The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy. (16705546)
2006
37
Risk factors of diabetic retinopathy in type 2 diabetic patients. (16732984)
2006
38
Angiopoietin concentrations in diabetic retinopathy. (15774928)
2005
39
Neuropeptide Y and Y2-receptor are involved in development of diabetic retinopathy and retinal neovascularization. (15181979)
2004
40
Aqueous levels of macrophage migration inhibitory factor and monocyte chemotactic protein-1 in patients with diabetic retinopathy. (15569131)
2004
41
-429T/C and -374T/A polymorphisms of RAGE gene promoter are not associated with diabetic retinopathy in Chinese patients with type 2 diabetes. (12941744)
2003
42
eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy. (11918626)
2002
43
Evidence that upregulation of serum IGF-1 concentration can trigger acceleration of diabetic retinopathy. (9924360)
1998
44
A 3-19-year follow-up study on diabetic retinopathy in patients diagnosed in childhood and treated with conventional therapy. (9400919)
1997
45
Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. (9298058)
1997
46
Screening for diabetic retinopathy. (7776911)
1995
47
The effect of diabetic control on diabetic retinopathy. (7607352)
1993
48
Asymmetric proliferative diabetic retinopathy and carotid artery disease. (2381700)
1990
49
Effect of pure O2-breathing on retinal blood flow in normals and in patients with background diabetic retinopathy. (6690224)
1984
50
Retinal ischemia (capillary nonperfusion) in diabetic retinopathy of patients with and without systemic hypertension. (745825)
1978

Variations for Diabetic Retinopathy

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Expression for genes affiliated with Diabetic Retinopathy

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Expression patterns in normal tissues for genes affiliated with Diabetic Retinopathy

Search GEO for disease gene expression data for Diabetic Retinopathy.

Pathways for genes affiliated with Diabetic Retinopathy

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Pathways related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ICAM1, VCAM1
29.7ICAM1, VTN, CTGF
3
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.6VEGFA, VCAM1, ICAM1
4
Show member pathways
9.6IGF1, TIMP3, VTN
59.5VEGFA, VTN, FGF2
69.5VCAM1, CXCL12, ICAM1
79.5VCAM1, CXCL12, ICAM1
8
Show member pathways
9.5VEGFA, TIMP3, FGF2
99.2VTN, IGF1, THBS1
109.1IGF1, VEGFA, HIF1A, ANGPT2
11
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1VTN, HIF1A, VEGFA, IGF1
12
Show member pathways
Proteogylcan syndecan-mediated signaling events37
9.1THBS1, VTN, FGF2
139.1FGF2, AGT, IGF1
149.1AGT, HIF1A, IGF1
159.0THBS1, CXCL12, FGF2
16
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.0VTN, VEGFA, IGF1, THBS1
179.0VTN, ICAM1, VCAM1, THBS1
18
Show member pathways
Angiogenesis37
9.0FGF2, TIMP3, HIF1A, VEGFA
198.9IGFBP1, VEGFA, HIF1A, ADM, CXCL12
208.9VEGFA, TGFB2, FGF2
218.9TGFB2, HIF1A, VEGFA
228.8VEGFA, TGFB2, CXCL12, ICAM1
238.7THBS1, IGF1, VEGFA, FGF2
24
Show member pathways
Signaling Pathways in Glioblastoma37
8.7THBS1, IGF1, VEGFA, FGF2
25
Show member pathways
8.7ANGPT2, CXCL12, SERPINF1, TGFB2, VEGFA
268.6THBS1, VEGFA, TIMP3, TGFB2
27
Show member pathways
8.5THBS1, IGF1, VEGFA, ANGPT2, FGF2
28
Show member pathways
8.4THBS1, IGF1, VEGFA, TGFB2
298.4THBS1, TGFB2, VCAM1, ICAM1
308.3THBS1, IGF1, VEGFA, ANGPT2, VTN, FGF2
318.3IGF1, VEGFA, TIMP3, TGFB2, FGF2
32
Show member pathways
8.2ANGPT2, TGFB2, VEGFA, IGF1, THBS1
338.1HIF1A, TIMP3, TGFB2, ANGPT2, FGF2
348.0IGF1, VEGFA, HIF1A, TGFB2, FGF2
35
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
36
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
37
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
38
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
39
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
40
Show member pathways
7.9IGF1, TIMP3, TGFB2, CXCL12, CTGF, FGF2
41
Show member pathways
7.8THBS1, TGFB2, VCAM1, CXCL12, ICAM1, VTN
42
Show member pathways
7.6IGF1, FGF2, CTGF, ANGPT2, CXCL12, TGFB2
43
Show member pathways
7.6CTGF, ANGPT2, CXCL12, TGFB2, TIMP3, IGF1
44
Show member pathways
7.6THBS1, TGFB2, VCAM1, ICAM1, VTN, FGF2
45
Show member pathways
7.4IGF1, TIMP3, TGFB2, SERPINF1, CXCL12, VTN
46
Show member pathways
7.2THBS1, IGF1, VEGFA, HIF1A, ADM, CXCL12
47
Show member pathways
7.2IGF1, TIMP3, TGFB2, CXCL12, ANGPT2, CTGF
48
Show member pathways
7.1IGF1, HIF1A, TIMP3, TGFB2, CXCL12, ANGPT2
496.9THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2
50
Show member pathways
6.5FGF2, IGF1, HIF1A, TIMP3, TGFB2, VCAM1

Compounds for genes affiliated with Diabetic Retinopathy

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Compounds related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1cobalt chloride448.9VCAM1, HIF1A, ADM, VEGFA
2diphenyleneiodonium448.7SERPINF1, HIF1A, VEGFA, AGT, VCAM1, ICAM1
3l-nmma448.7ADM, IGF1, AGT, HIF1A, VCAM1
4herbimycin a44 619.6VCAM1, CXCL12, ICAM1, VTN, FGF2, IGFBP1
5mannitol44 119.5ICAM1, CTGF, ADM, VCAM1, HIF1A, FGF2
6ribonucleic acid447.9IGF1, CTGF, ANGPT2, THBS1, CXCL12, TGFB2
7potassium44 24 119.8SERPINF1, AGT, VTN, CXCL12, ADM, TGFB2
8tgf beta1447.8TIMP3, TGFB2, FGF2, THBS1, VCAM1, CTGF
9glycosaminoglycan447.8TGFB2, THBS1, CXCL12, TIMP3, SERPINF1, FGF2
10cytochalasin d44 618.8VTN, IGF1, CXCL12, ICAM1, FGF2, CTGF
11fibrinogen447.8ANGPT2, ICAM1, CXCL12, VCAM1, IGFBP1, VTN
12prostacyclin447.7FGF2, AGT, CTGF, VTN, ICAM1, ADM
13rapamycin447.7AGT, CTGF, HIF1A, VEGFA, IGFBP1, IGF1
14n acetylcysteine447.7VCAM1, AGT, CTGF, ICAM1, VEGFA, HIF1A
15creatinine447.6IGFBP1, IGF1, TGFB2, ADM, ANGPT2, AGT
16prostaglandin447.6TGFB2, CXCL12, AGT, THBS1, CTGF, ADM
17actinomycin d447.6IGF1, IGFBP1, VEGFA, HIF1A, ADM, CXCL12
18cholesterol44 28 24 1110.5AGT, THBS1, IGF1, IGFBP1, ADM, CXCL12
19hyaluronic acid44 248.5VEGFA, CXCL12, ICAM1, VTN, FGF2, TGFB2
20steroid447.4AGT, GAD1, ANGPT2, ADM, CXCL12, IGF1
21arginine447.4VTN, AGT, IGF1, GAD1, TIMP3, IGFBP1
22progesterone44 28 61 24 1111.3CXCL12, ADM, TGFB2, IGFBP1, IGF1, THBS1
23wortmannin447.3VTN, ANGPT2, CXCL12, ADM, VCAM1, TIMP3
24estradiol44 24 119.2IGF1, GAD1, IGFBP1, TIMP3, TGFB2, CXCL12
25h2o2447.1THBS1, AGT, CTGF, GAD1, HIF1A, SERPINF1
26testosterone44 61 24 1110.1VCAM1, IGF1, THBS1, IGFBP1, HIF1A, TIMP3
27tamoxifen44 50 28 119.9THBS1, IGF1, VTN, CXCL12, ADM, VCAM1
28sb 20358044 617.9THBS1, IGF1, VEGFA, HIF1A, FGF2, AGT
29oligonucleotide446.9AGT, GAD1, ADM, TGFB2, TIMP3, HIF1A
30paraffin446.6ADM, VCAM1, TIMP3, HIF1A, VEGFA, THBS1
31pd 98,059446.6FGF2, AGT, CTGF, VTN, ICAM1, CXCL12
32oxygen44 247.5TIMP3, HIF1A, IGFBP1, THBS1, SERPINF1, VCAM1
33cyclosporin a44 28 618.5CTGF, GAD1, FGF2, TGFB2, ICAM1, ADM
34heparin44 28 24 119.3VEGFA, SERPINF1, THBS1, IGFBP1, TIMP3, TGFB2
35nitric oxide44 24 118.3AGT, CTGF, GAD1, ICAM1, ANGPT2, ADM
36thymidine44 247.3ADM, TGFB2, HIF1A, IGFBP1, IGF1, THBS1
37pge2446.2HIF1A, VEGFA, IGFBP1, AGT, CTGF, VTN
38ly294002446.2ANGPT2, CXCL12, VCAM1, TIMP3, HIF1A, VEGFA
39cycloheximide446.2FGF2, CTGF, THBS1, IGF1, VTN, ICAM1
40matrigel446.0CXCL12, SERPINF1, TGFB2, VEGFA, THBS1, FGF2
41cysteine446.0VCAM1, ADM, ANGPT2, VTN, GAD1, CTGF
42glucose445.9AGT, CTGF, GAD1, ANGPT2, ADM, VCAM1
43genistein44 28 61 2 24 1110.9HIF1A, VEGFA, IGFBP1, IGF1, THBS1, TIMP3
44estrogen445.9IGF1, IGFBP1, VEGFA, HIF1A, TIMP3, TGFB2
45retinoic acid44 246.6ANGPT2, ICAM1, VTN, CTGF, FGF2, ADM
46serine445.6FGF2, THBS1, IGF1, IGFBP1, HIF1A, ANGPT2
47phosphatidylinositol445.1IGFBP1, IGF1, THBS1, VTN, ICAM1, ANGPT2
48dexamethasone44 50 28 117.7HIF1A, VEGFA, IGFBP1, IGF1, THBS1, CTGF
49vegf444.6VEGFA, HIF1A, TIMP3, SERPINF1, VCAM1, ADM
50tyrosine444.5THBS1, IGF1, VEGFA, HIF1A, TIMP3, TGFB2

GO Terms for genes affiliated with Diabetic Retinopathy

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Cellular components related to Diabetic Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9ICAM1, CXCL12, VCAM1, THBS1
2platelet alpha granule lumenGO:0310938.3THBS1, IGF1, VEGFA, TGFB2
3extracellular matrixGO:0310128.0THBS1, TIMP3, TGFB2, SERPINF1, VTN
4extracellular regionGO:0055765.7THBS1, IGF1, IGFBP1, VEGFA, TGFB2, SERPINF1
5extracellular spaceGO:0056155.1FGF2, THBS1, IGF1, IGFBP1, VEGFA, TGFB2

Biological processes related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idNameGO IDScoreTop Affiliating Genes
1cell adhesion mediated by integrinGO:03362710.3ICAM1, VTN
2positive regulation of axon extension involved in axon guidanceGO:04884210.3VEGFA, CXCL12
3membrane to membrane dockingGO:02261410.2VCAM1, ICAM1
4positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141910.1VEGFA, HIF1A
5organ regenerationGO:03110010.1ADM, CXCL12, ANGPT2
6positive regulation of smooth muscle cell migrationGO:01491110.0VTN, IGF1
7induction of positive chemotaxisGO:05093010.0CXCL12, VEGFA
8positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.9VEGFA, HIF1A, VTN
9positive regulation of cerebellar granule cell precursor proliferationGO:0219409.9IGF1, FGF2
10dopaminergic neuron differentiationGO:0715429.9VEGFA, HIF1A
11kidney developmentGO:0018229.8VEGFA, SERPINF1, AGT
12positive regulation of cardiac muscle hypertrophyGO:0106139.8IGF1, AGT
13cell-matrix adhesionGO:0071609.8AGT, CTGF, VTN
14lung developmentGO:0303249.8VEGFA, CTGF, FGF2
15positive regulation of glycolytic processGO:0458219.7IGF1, HIF1A
16chronic inflammatory responseGO:0025449.7VCAM1, THBS1
17negative regulation of endopeptidase activityGO:0109519.7AGT, VTN, SERPINF1, TIMP3
18cellular response to hypoxiaGO:0714569.7VEGFA, HIF1A, ICAM1
19response to glucoseGO:0097499.7CTGF, ANGPT2, THBS1
20response to mechanical stimulusGO:0096129.7ANGPT2, CXCL12, THBS1
21agingGO:0075689.6AGT, ADM, VCAM1, SERPINF1
22glial cell differentiationGO:0100019.6IGF1, FGF2
23positive regulation of endothelial cell migrationGO:0105959.6AGT, VEGFA, THBS1
24positive regulation of blood vessel endothelial cell migrationGO:0435369.6THBS1, VEGFA, FGF2
25negative regulation of blood vessel endothelial cell migrationGO:0435379.5FGF2, ANGPT2, THBS1
26cellular response to tumor necrosis factorGO:0713569.5ICAM1, VCAM1, THBS1
27outflow tract morphogenesisGO:0031519.5THBS1, VEGFA, HIF1A
28regulation of transforming growth factor beta2 productionGO:0329099.5TGFB2, HIF1A
29response to woundingGO:0096119.5TGFB2, ADM, CTGF
30cell migration involved in sprouting angiogenesisGO:0020429.5FGF2, VEGFA
31negative regulation of angiogenesisGO:0165259.4AGT, ANGPT2, SERPINF1, THBS1
32positive regulation of endothelial cell proliferationGO:0019389.3VEGFA, HIF1A, CXCL12, FGF2
33positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3IGF1, VEGFA, ICAM1, VTN, AGT
34positive regulation of cell divisionGO:0517819.3FGF2, TGFB2, VEGFA
35blood vessel remodelingGO:0019749.2IGF1, TGFB2, AGT
36positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.1IGF1, TGFB2, AGT
37cell adhesionGO:0071559.0THBS1, VCAM1, CXCL12, ICAM1, VTN
38angiogenesisGO:0015258.9VEGFA, HIF1A, TGFB2, ANGPT2, CTGF
39platelet degranulationGO:0025768.8THBS1, IGF1, VEGFA, TGFB2
40platelet activationGO:0301688.8TGFB2, VEGFA, IGF1, THBS1
41negative regulation of cell growthGO:0303088.7TGFB2, AGT, FGF2
42cell migrationGO:0164778.6THBS1, TGFB2, CTGF
43response to drugGO:0424938.6GAD1, ICAM1, TGFB2, THBS1
44positive regulation of angiogenesisGO:0457668.6THBS1, VEGFA, HIF1A, ADM, ANGPT2, FGF2
45blood coagulationGO:0075968.6THBS1, IGF1, VEGFA, TGFB2, ANGPT2
46negative regulation of cell proliferationGO:0082858.4IGF1, TGFB2, ADM, AGT, FGF2
47positive regulation of cell proliferationGO:0082848.4IGF1, VEGFA, TGFB2, ADM, CTGF, FGF2
48signal transductionGO:0071658.4IGF1, IGFBP1, HIF1A, ADM, CXCL12, ANGPT2
49response to hypoxiaGO:0016667.6ANGPT2, THBS1, VEGFA, HIF1A, TGFB2, VCAM1
50extracellular matrix organizationGO:0301987.6THBS1, TGFB2, VCAM1, ICAM1, VTN, AGT

Molecular functions related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix bindingGO:05084010.0VTN, VEGFA
2insulin-like growth factor bindingGO:00552010.0CTGF, IGFBP1
3fibronectin bindingGO:0019689.6CTGF, VEGFA, THBS1
4hormone activityGO:0051799.5AGT, ADM, IGF1
5chemoattractant activityGO:0420569.5FGF2, VEGFA
6fibroblast growth factor bindingGO:0171349.2THBS1, FGF2
7receptor bindingGO:0051029.1TGFB2, ADM, CXCL12, ANGPT2
8cytokine activityGO:0051258.9FGF2, TGFB2, VEGFA
9heparin bindingGO:0082018.8THBS1, VEGFA, VTN, CTGF, FGF2
10protein heterodimerization activityGO:0469828.7VEGFA, HIF1A, TGFB2, GAD1
11integrin bindingGO:0051788.5THBS1, IGF1, VCAM1, ICAM1, VTN, CTGF
12growth factor activityGO:0080837.7FGF2, IGF1, VEGFA, TGFB2, CXCL12, CTGF
13protein bindingGO:0055155.2TGFB2, TIMP3, HIF1A, VEGFA, IGF1, THBS1

Products for genes affiliated with Diabetic Retinopathy

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Sources for Diabetic Retinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
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