MCID: DBT011
MIFTS: 73

Diabetic Retinopathy malady

Eye diseases category

Summaries for Diabetic Retinopathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diabetic retinopathy, ([ˌrɛtnˈɑpəθi]) is retinopathy (damage to the retina) caused by... more...

MalaCards: Diabetic Retinopathy, also known as retinal abnormality - diabetes-related, is related to proliferative diabetic retinopathy and diabetes mellitus. An important gene associated with Diabetic Retinopathy is VEGFA (vascular endothelial growth factor A), and among its related pathways are Signaling by GPCR and Rho Family GTPases. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and retina, and related mouse phenotypes are mortality/aging and cellular.

Aliases & Classifications for Diabetic Retinopathy

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

diabetic retinopathy 8 22 10 44 30 60
retinal abnormality - diabetes-related 8
diabetic retinopathy nos 8


External Ids:

Disease Ontology8 DOID:8947
MeSH34 D003930
NCIt39 C34538
ICD9CM27 362.0
ICD1025 H36.0

Related Diseases for Diabetic Retinopathy

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17GeneCards, 18GeneDecks
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Diseases related to Diabetic Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 262)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative diabetic retinopathy32.0TGFB2, ADM, VTN, SERPINF1, VCAM1, THBS1
2diabetes mellitus31.3VTN, VCAM1, IGF1, IGFBP1, ANGPT2, VEGFA
3diabetic macular edema31.2SERPINF1, VEGFA
4type 2 diabetes mellitus31.0ADM, VCAM1, IGF1, IGFBP1, AGT, GAD1
5diabetic nephropathy30.9ADM, SERPINF1, THBS1, AGT, FLT1, CTGF
6retinal detachment30.9TGFB2, SERPINF1, VEGFA
7proliferative vitreoretinopathy30.9TGFB2, ADM, VTN, THBS1, FGF2, CTGF
8glaucoma30.9TGFB2, SERPINF1, CTGF
9neovascular glaucoma30.7VEGFA
10cataract30.7TGFB2, SERPINF1, CTGF
11ischemia30.6TGFB2, ADM, VTN, CXCL12, FGF2, HIF1A
12age related macular degeneration30.6VEGFA, FLT1, TIMP3
13leukostasis30.5VCAM1, ICAM1
14retinal ischemia30.5HIF1A, VEGFA
15atherosclerosis30.4VTN, SERPINF1, VCAM1, THBS1, CXCL12, FGF2
16hyperglycemia30.4VTN, SERPINF1, VCAM1, HIF1A, IGF1, IGFBP1
17proteinuria30.4ADM, VTN, ANGPT2, VEGFA, AGT, FLT1
18hypertension30.4ADM, VCAM1, IGF1, AGT, ICAM1
19macular holes30.4TGFB2, ADM, SERPINF1, ANGPT2
20macular retinal edema30.4SERPINF1, CXCL12, VEGFA
21retinal disease30.3ADM, SERPINF1, VCAM1, FGF2, HIF1A, IGF1
22obesity30.3THBS1, HIF1A, IGF1, IGFBP1, AGT, FLT1
23eye disease30.3TGFB2, SERPINF1, IGFBP1
24retinal vein occlusion30.3VEGFA
25leukemia30.2SERPINF1, CXCL12, FGF2, IGFBP1, ANGPT2, NRP1
26vascular disease30.2VTN, VCAM1, FGF2, ANGPT2, VEGFA, AGT
27myocardial infarction30.2ADM, CXCL12, HIF1A, IGFBP1, AGT, CTGF
28coronary artery disease30.2VTN, VCAM1, HIF1A, IGFBP1, AGT, ICAM1
29uveitis30.2TGFB2, SERPINF1, ICAM1
30acromegaly30.2IGF1, IGFBP1
31osteoarthritis29.9TGFB2, VCAM1, THBS1, CXCL12, FGF2, IGF1
32hypoglycemia29.9HIF1A, IGF1, IGFBP1, GAD1
33vascular cancer29.9THBS1, FGF2, VEGFA, FLT1
34stroke, ischemic29.9ADM, VCAM1, ICAM1
35retinal vascular disease29.9SERPINF1, VEGFA, CTGF
36pre-eclampsia29.9FLT1
37nephrosclerosis29.9ADM
38acute leukemia29.9CXCL12
39severe pre-eclampsia29.9VCAM1, IGFBP1
40hypothyroidism29.9IGF1
41retinitis11.0
42background diabetic retinopathy10.6
43severe nonproliferative diabetic retinopathy10.6
44type 1 diabetes mellitus10.5
45diabetic cataract10.5
46vitreous detachment10.5
47neuronitis10.4
48diabetic neuropathy10.4
49neuropathy10.4
50choroiditis10.4

Graphical network of the top 20 diseases related to Diabetic Retinopathy:



Diseases related to diabetic retinopathy

Clinical Features for Diabetic Retinopathy

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Drugs & Therapeutics for Diabetic Retinopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Retinopathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Retinopathy

Search NIH Clinical Center for Diabetic Retinopathy

Search CenterWatch for Diabetic Retinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Retinopathy cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Retinopathy

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22GTR
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Genetic tests related to Diabetic Retinopathy:

id Genetic test Affiliating Genes
1 Diabetic Retinopathy22

Anatomical Context for Diabetic Retinopathy

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Diabetic Retinopathy:

32
Endothelial, Eye, Retina, Bone, Monocytes, Heart, Testes, Kidney, Myeloid, Placenta, Thyroid, Ovary, T cells, Liver, Tongue, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Retinopathy:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeInner Nuclear LayerMature Muller Glia Cells Affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease

Animal Models for Diabetic Retinopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diabetic Retinopathy:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.3THBS1, ADM, TGFB2, CXCL12, FGF2, HIF1A
2MP:000538412.3VCAM1, ADM, TGFB2, CTGF, ICAM1, TIMP3
3MP:000538712.2ANGPT2, CXCL12, ICAM1, VEGFA, AGT, IGFBP1
4MP:000537811.9TIMP3, ICAM1, GAD1, FLT1, NRP1, AGT
5MP:000538511.9TGFB2, CTGF, FLT1, NRP1, AGT, ANGPT2
6MP:000539711.7THBS1, ICAM1, VTN, VCAM1, CXCL12, FGF2
7MP:000536911.6FLT1, ICAM1, AGT, IGF1, HIF1A, FGF2
8MP:000537611.6VTN, TIMP3, ICAM1, CTGF, GAD1, AGT
9MP:000538111.6ICAM1, CTGF, GAD1, VEGFA, ANGPT2, HIF1A
10MP:000538811.5TIMP3, GAD1, CTGF, IGF1, HIF1A, TGFB2
11MP:000539111.4ANGPT2, HIF1A, FGF2, THBS1, SERPINF1, TIMP3
12MP:000537011.4IGFBP1, AGT, TIMP3, THBS1, HIF1A, CXCL12
13MP:000538911.2TGFB2, SERPINF1, THBS1, VEGFA, FLT1
14MP:000536711.1TGFB2, HIF1A, TIMP3, AGT, THBS1, ADM
15MP:000287311.1HIF1A, CXCL12, IGF1, VEGFA, FLT1, GAD1
16MP:001077111.1CTGF, TIMP3, VEGFA, HIF1A, ANGPT2
17MP:000363111.1NRP1, GAD1, AGT, SERPINF1
18MP:000538211.0VEGFA, GAD1, NRP1, TGFB2, HIF1A, CTGF
19MP:000538011.0CTGF, ADM, GAD1, VCAM1, TGFB2
20MP:000539010.9CTGF, TGFB2, FGF2, IGF1, VEGFA
21MP:000537910.8SERPINF1, ICAM1
22MP:000200610.4THBS1, ICAM1, IGF1

Publications for Diabetic Retinopathy

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50PubMed
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Articles related to Diabetic Retinopathy:

(show top 50)    (show all 1728)
idTitleAuthorsYear
1
Suppression of protein kinase C-IP attenuates vascular leakage via prevention of tight junction protein decrease in diabetic retinopathy. (24434146)
2014
2
Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy. (23037145)
2013
3
Relationship between coronary artery disease and retinopathy in patients with type 2 diabetes mellitus. (24240785)
2013
4
Genetics in diabetic retinopathy: current concepts and new insights. (24403848)
2013
5
Effect of I+-linolenic acid on streptozotocin-induced diabetic retinopathy indices in vivo. (24120388)
2013
6
Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition. (24133029)
2013
7
Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. (23353834)
2013
8
Australian optometric and ophthalmologic referral pathways for people with age-related macular degeneration, diabetic retinopathy and glaucoma. (24400653)
2013
9
Risk factors and diabetic retinopathy. (23348194)
2013
10
The potential association between obstructive sleep apnea and diabetic retinopathy in severe obesity-the role of hypoxemia. (24260240)
2013
11
Enzyme-induced vitreolysis can alleviate the progression of diabetic retinopathy through the HIF-1I+ pathway. (23847321)
2013
12
Inflammatory biomarkers and progression of diabetic retinopathy in African Americans with type 1 diabetes. (23847308)
2013
13
The influence of background diabetic retinopathy in the second eye on rates of progression of diabetic retinopathy between 2005 and 2010. (23551550)
2013
14
Assessing progress in retinopathy outcomes in type 1 diabetes: comparing findings from the Wisconsin Diabetes Registry Study and the Wisconsin Epidemiologic Study of Diabetic Retinopathy. (23193204)
2013
15
A role for systemic inflammation in diabetic retinopathy. (23539166)
2013
16
Racial disparities in screening for diabetic retinopathy in youth with type 1 diabetes. (23642967)
2013
17
Meta-analysis of association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-I^2 gene and diabetic retinopathy in Caucasians and Asians. (22993484)
2012
18
Novel diabetic mouse models as tools for investigating diabetic retinopathy. (23251343)
2012
19
Diabetic retinopathy grading by digital curvelet transform. (23056148)
2012
20
Resveratrol improves diabetic retinopathy possibly through oxidative stress - nuclear factor I_B - apoptosis pathway. (23406761)
2012
21
Helping patients find their way to better diabetic retinopathy care. (23139451)
2012
22
Macular edema formation and deterioration of retinal function after intravitreal bevacizumab injection for proliferative diabetic retinopathy. (22125532)
2011
23
Evaluation of the relationship between background factors and sleep-disordered breathing in patients with proliferative diabetic retinopathy. (21874309)
2011
24
Rubosixtaurin and other PKC inhibitors in diabetic retinopathy and macular edema. Review. (19199893)
2009
25
Spontaneous resolution of macular edema after panretinal photocoagulation in florid proliferative diabetic retinopathy. (19629019)
2009
26
Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy. (19553613)
2009
27
Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathy. (17001327)
2008
28
Combined rhegmatogenous and traction retinal detachment in proliferative diabetic retinopathy: clinical manifestations and surgical outcome. (18347622)
2008
29
TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy. (18316703)
2008
30
Profiling of vitreous proteomes from proliferative diabetic retinopathy and nondiabetic patients. (17955474)
2007
31
Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics study. (17513698)
2007
32
Structural alterations of the erythrocyte membrane proteins in diabetic retinopathy. (17219119)
2007
33
The Leu7Pro polymorphism of neuropeptide Y is associated with younger age of onset of type 2 diabetes mellitus and increased risk for nephropathy in subjects with diabetic retinopathy. (16705546)
2006
34
Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. (17011761)
2006
35
Combining phacoemulsification with pars plana vitrectomy in patients with proliferative diabetic retinopathy: a series of 223 cases. (12867387)
2003
36
The - 429 T/C and - 374 T/A gene polymorphisms of the receptor of advanced glycation end products gene are not risk factors for diabetic retinopathy in Caucasians with type 2 diabetes. (14704946)
2003
37
Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. (10741691)
2000
38
Release of the angiogenesis inhibitor angiostatin in patients with proliferative diabetic retinopathy: association with retinal photocoagulation. (11126410)
2000
39
One-year outcomes of panretinal photocoagulation in proliferative diabetic retinopathy. (10682970)
2000
40
Elevated vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. (12579655)
1999
41
Inverse relationship between GAD65 antibody levels and severe retinopathy in younger type 1 diabetic patients. (9699085)
1998
42
Analysis of the blood-retinal barrier: its relation to clinical and metabolic factors and progression to retinopathy in juvenile diabetics. A 4-year follow-up study. (8964530)
1996
43
Metabolic factors in the development of retinopathy of juvenile-onset type I diabetes mellitus. (7927626)
1994
44
Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy. (7947554)
1994
45
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. (7943121)
1994
46
Macrophages in proliferative vitreoretinopathy and proliferative diabetic retinopathy: differentiation of subpopulations. (8280690)
1993
47
von Willebrand factor and early diabetic retinopathy: no evidence for a relationship in patients with type 1 (insulin-dependent) diabetes mellitus and normal urinary albumin excretion. (1612229)
1992
48
Blood glucose concentrations and progression of diabetic retinopathy: the seven year results of the Oslo study. (1734985)
1992
49
The relationship of retinal microaneurysm counts to the 4-year progression of diabetic retinopathy. (2597068)
1989
50
Femoral versus peroneal neuropathy in diabetic children and adolescents--relationships to clinical status, metabolic control and retinopathy. (3595967)
1987

Genetic Variations for Diabetic Retinopathy

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Expression for genes affiliated with Diabetic Retinopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diabetic Retinopathy

Search GEO for disease gene expression data for Diabetic Retinopathy.

Pathways for genes affiliated with Diabetic Retinopathy

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 49PharmGKB, 55SinoBiological, 12EMD Millipore
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Pathways related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6VCAM1, VTN, HIF1A, ADM, FLT1, NRP1
2
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11.4TIMP3, CTGF, TGFB2, FLT1, CXCL12, HIF1A
311.2VEGFA, VTN, TIMP3, IGF1, FGF2, HIF1A
4
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11.2TIMP3, CTGF, FLT1, ANGPT2, IGF1, FGF2
511.1FLT1, VEGFA, VTN, THBS1, IGF1, FGF2
6
Hide members
11.1TIMP3, CXCL12, CTGF, FLT1, NRP1, IGF1
7
Hide members
11.1CXCL12, VTN, NRP1, FLT1, CTGF, TIMP3
8
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11.1CXCL12, FLT1, IGF1, CTGF, TIMP3, FGF2
9
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11.1CXCL12, CTGF, FLT1, NRP1, IGF1, FGF2
10
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11.0CTGF, IGF1, NRP1, FLT1, TIMP3, FGF2
1110.9ADM, CXCL12, VEGFA, IGFBP1, HIF1A
12
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10.9VCAM1, THBS1, CXCL12, ICAM1, VTN
1310.9VEGFA, HIF1A, ANGPT2, FLT1, IGF1
14
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10.9ANGPT2, AGT, FLT1, CTGF, TIMP3
15
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10.9FLT1, VEGFA, VTN, THBS1, IGF1
1610.9HIF1A, FLT1, FGF2, TIMP3, VEGFA
1710.9ANGPT2, FGF2, HIF1A, FLT1, TIMP3
18
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10.9FLT1, NRP1, VEGFA, FGF2, TIMP3
19
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10.9TIMP3, FLT1, FGF2, NRP1, CTGF
20
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10.8VCAM1, VTN, FGF2, ICAM1
21
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10.8ICAM1, VEGFA, NRP1, VCAM1
22
Hide members
10.8CXCL12, TIMP3, CTGF, IGF1
2310.8FGF2, THBS1, VEGFA, IGF1
24
Hide members
10.8FLT1, NRP1, HIF1A, VEGFA
25
Hide members
10.8CXCL12, NRP1, FLT1, CTGF
26
Cell adhesion ECM remodeling
Hide members
10.8IGF1, TIMP3, VTN
2710.8CXCL12, VCAM1, ICAM1
2810.7ICAM1, CTGF, VTN
2910.7VEGFA, FLT1, IGF1
30
Hide members
10.7AGT, NRP1, TIMP3
31
Hide members
10.7NRP1, FLT1, VEGFA
3210.7CXCL12, FGF2, THBS1
3310.7VTN, VEGFA
3410.7IGF1, TIMP3
35
Hide members
10.7THBS1, VEGFA
3610.7FGF2, HIF1A
37
Hide members
10.6IGF1
3810.6FLT1
3910.6NRP1

Compounds for genes affiliated with Diabetic Retinopathy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.6TIMP3, ICAM1, CTGF, GAD1, FLT1, NRP1
2vegf4412.6TIMP3, ICAM1, FLT1, NRP1, AGT, VEGFA
3phosphatidylinositol4412.5VTN, ADM, TGFB2, VCAM1, THBS1, TIMP3
4nitric oxide44 11 2414.2ICAM1, CTGF, GAD1, FLT1, NRP1, AGT
5cysteine4412.2TIMP3, CTGF, GAD1, NRP1, AGT, ANGPT2
6retinoic acid44 2413.1ICAM1, IGF1, IGFBP1, ANGPT2, CTGF, TIMP3
7glucose4412.1FLT1, NRP1, AGT, ANGPT2, IGF1, HIF1A
8genistein44 28 59 2 11 2417.1TGFB2, VCAM1, THBS1, CXCL12, ICAM1, FLT1
9thymidine44 2413.0HIF1A, FGF2, CXCL12, THBS1, ADM, TGFB2
10ly2940024411.9TIMP3, ICAM1, CTGF, AGT, VEGFA, ANGPT2
11wortmannin4411.9ADM, VTN, TIMP3, NRP1, AGT, ANGPT2
12pd 98,0594411.9THBS1, VCAM1, VTN, CXCL12, FGF2, TIMP3
13dexamethasone44 49 28 1114.9VEGFA, ANGPT2, AGT, CTGF, TIMP3, HIF1A
14sb 20358044 5912.9ICAM1, CTGF, FLT1, AGT, VEGFA, IGF1
15paraffin4411.9TIMP3, ANGPT2, FLT1, AGT, VEGFA, FGF2
16heparin44 28 11 2414.8TIMP3, CTGF, FLT1, NRP1, AGT, VEGFA
17h2o24411.8ADM, SERPINF1, ICAM1, CTGF, GAD1, FLT1
18prostacyclin4411.8ICAM1, CTGF, FLT1, AGT, VEGFA, FGF2
19cholesterol44 28 11 2414.8IGF1, CXCL12, THBS1, VCAM1, VTN, ADM
20arginine4411.8ADM, VCAM1, CXCL12, HIF1A, IGF1, IGFBP1
21calcium44 49 11 2414.8NRP1, TGFB2, IGFBP1, ANGPT2, CXCL12, SERPINF1
22ribonucleic acid4411.8IGF1, IGFBP1, ANGPT2, CXCL12, NRP1, CTGF
23oxygen44 2412.7TIMP3, ICAM1, GAD1, FLT1, AGT, ANGPT2
24hyaluronic acid44 2412.7THBS1, CXCL12, FGF2, VEGFA, NRP1, VCAM1
25lipid4411.7TIMP3, ADM, VTN, FLT1, VCAM1, NRP1
26cyclosporin a44 28 5913.6ICAM1, HIF1A, TGFB2, ADM, THBS1, FGF2
27fibrinogen4411.6THBS1, ICAM1, CTGF, AGT, IGFBP1, ANGPT2
28rapamycin4411.6CXCL12, THBS1, HIF1A, IGFBP1, VEGFA, AGT
29actinomycin d4411.6VEGFA, ADM, ICAM1, AGT, IGFBP1, IGF1
30steroid4411.6NRP1, TGFB2, ADM, CXCL12, IGFBP1, ANGPT2
31glycosaminoglycan4411.6THBS1, FGF2, TIMP3, CXCL12, TGFB2, VTN
32cytochalasin d44 5912.6THBS1, VTN, VCAM1, FGF2, CTGF, ICAM1
33matrigel4411.6NRP1, HIF1A, CXCL12, THBS1, VTN, TGFB2
34progesterone44 59 28 11 2415.5FLT1, TIMP3, GAD1, TGFB2, ADM, THBS1
35n acetylcysteine4411.5ICAM1, TGFB2, SERPINF1, VCAM1, HIF1A, VEGFA
36serine4411.5VTN, FLT1, SERPINF1, THBS1, FGF2, AGT
37tamoxifen44 49 28 1114.4IGFBP1, VCAM1, VTN, THBS1, CXCL12, IGF1
38tgf beta14411.4CTGF, FLT1, THBS1, FGF2, VCAM1, TGFB2
39creatinine4411.4TGFB2, GAD1, FLT1, AGT, IGF1, ANGPT2
40alanine4411.3VCAM1, VTN, IGFBP1, THBS1, FGF2, NRP1
41guanylate4411.2SERPINF1, ANGPT2, NRP1, FLT1, ADM, AGT
42pge24411.1VEGFA, VTN
43cycloheximide4411.0CXCL12, IGFBP1
44hydrocortisone44 2 59 1114.0ADM, IGFBP1, FGF2, FLT1, IGF1
45estradiol44 11 2413.0TGFB2, TIMP3, GAD1
46diphenyleneiodonium4411.0SERPINF1, VCAM1
47l-nmma4410.9ADM, AGT, VCAM1, HIF1A, IGF1
48herbimycin a44 5911.9IGFBP1, FGF2, CXCL12, VCAM1, VTN, ICAM1
49mannitol44 1111.7ICAM1
50cobalt chloride4410.5VEGFA, HIF1A, VCAM1, ADM

GO Terms for genes affiliated with Diabetic Retinopathy

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Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561512.0TGFB2, ICAM1, CTGF, FLT1, AGT, VEGFA
2extracellular regionGO:00557611.7IGFBP1, ANGPT2, VEGFA, AGT, NRP1, CTGF
3external side of plasma membraneGO:00989710.8VCAM1, THBS1, CXCL12, ICAM1
4platelet alpha granule lumenGO:03109310.7VEGFA, IGF1, THBS1, TGFB2
5extracellular matrixGO:03101210.6TIMP3, THBS1, SERPINF1, VTN, TGFB2

Biological processes related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.6NRP1, ANGPT2, IGFBP1, IGF1, HIF1A, FGF2
2response to hypoxiaGO:00166611.6VEGFA, ANGPT2, HIF1A, THBS1, VCAM1, ADM
3positive regulation of angiogenesisGO:04576611.6ADM, FLT1, VEGFA, ANGPT2, HIF1A, FGF2
4positive regulation of cell proliferationGO:00828411.6CTGF, FLT1, VEGFA, IGF1, FGF2, ADM
5cell adhesionGO:00715511.4ICAM1, NRP1, CXCL12, THBS1, VCAM1, VTN
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.4NRP1, AGT, VEGFA, IGF1, VTN
7angiogenesisGO:00152511.3CTGF, VEGFA, ANGPT2, HIF1A, TGFB2
8extracellular matrix organizationGO:03019811.3AGT, FGF2, THBS1, VTN, TGFB2
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094911.3VTN, HIF1A, VEGFA, FLT1
10positive regulation of endothelial cell migrationGO:01059511.3NRP1, AGT, VEGFA, THBS1
11patterning of blood vesselsGO:00156911.3CXCL12, VEGFA, NRP1, FLT1
12negative regulation of cell proliferationGO:00828511.3AGT, IGF1, FGF2, ADM, TGFB2
13positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.3FLT1, AGT, IGF1, TGFB2
14response to woundingGO:00961111.3CTGF, NRP1, ADM, TGFB2
15positive regulation of endothelial cell proliferationGO:00193811.3FGF2, HIF1A, VEGFA, NRP1
16platelet degranulationGO:00257611.2VEGFA, IGF1, THBS1, TGFB2
17cell migrationGO:01647711.2CTGF, FLT1, THBS1, TGFB2
18heart developmentGO:00750711.2NRP1, VCAM1, ADM, TGFB2
19positive regulation of smooth muscle cell migrationGO:01491111.2NRP1, IGF1, VTN
20negative regulation of blood vessel endothelial cell migrationGO:04353711.2THBS1, FGF2, ANGPT2
21positive regulation of blood vessel endothelial cell migrationGO:04353611.2THBS1, FGF2, VEGFA
22vascular endothelial growth factor receptor signaling pathwayGO:04801011.1FLT1, NRP1, VEGFA
23positive chemotaxisGO:05091811.1FGF2, VEGFA, NRP1
24blood vessel remodelingGO:00197411.1TGFB2, IGF1, AGT
25outflow tract morphogenesisGO:00315111.1VEGFA, HIF1A, THBS1
26blood coagulationGO:00759611.1VEGFA, ANGPT2, IGF1, THBS1, TGFB2
27positive regulation of cell divisionGO:05178111.1VEGFA, FGF2, TGFB2
28regulation of retinal ganglion cell axon guidanceGO:09025911.0VEGFA, NRP1
29positive regulation of retinal ganglion cell axon guidanceGO:190233611.0VEGFA, NRP1
30negative regulation of angiogenesisGO:01652511.0ANGPT2, THBS1, SERPINF1
31platelet activationGO:03016811.0VEGFA, IGF1, THBS1, TGFB2
32positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141911.0VEGFA, HIF1A
33positive regulation of axon extension involved in axon guidanceGO:04884211.0NRP1, VEGFA
34positive regulation of cerebellar granule cell precursor proliferationGO:02194011.0IGF1, FGF2
35response to glucose stimulusGO:00974911.0CTGF, ANGPT2, THBS1
36regulation of transforming growth factor beta2 productionGO:03290911.0TGFB2, HIF1A
37positive regulation of MAPK cascadeGO:04341011.0FLT1, AGT, IGF1
38embryonic morphogenesisGO:04859811.0FLT1, FGF2
39negative regulation of endopeptidase activityGO:01095111.0AGT, SERPINF1, VTN
40cell adhesion mediated by integrinGO:03362711.0ICAM1, VTN
41membrane to membrane dockingGO:02261411.0ICAM1, VCAM1
42endothelial cell chemotaxisGO:03576710.9VEGFA, NRP1
43commissural neuron axon guidanceGO:07167910.9VEGFA, NRP1
44cell-matrix adhesionGO:00716010.9VTN, AGT, CTGF
45cell-cell signalingGO:00726710.8NRP1, AGT, ADM, TGFB2
46positive regulation of phospholipase C activityGO:01086310.8FGF2, FLT1
47chronic inflammatory responseGO:00254410.7VCAM1, THBS1
48positive regulation of glycolysisGO:04582110.7HIF1A, IGF1
49lung developmentGO:03032410.6FGF2, VEGFA, CTGF
50cellular response to hypoxiaGO:07145610.5ICAM1, VEGFA, HIF1A

Molecular functions related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.0AGT, NRP1, FLT1, GAD1, CTGF, ICAM1
2growth factor activityGO:00808311.3TGFB2, CTGF, AGT, VEGFA, IGF1, FGF2
3integrin bindingGO:00517811.2ICAM1, CTGF, IGF1, THBS1, VCAM1, VTN
4heparin bindingGO:00820111.1CTGF, NRP1, VEGFA, FGF2, THBS1, VTN
5fibronectin bindingGO:00196810.8CTGF, VEGFA, THBS1
6hormone activityGO:00517910.7ADM, IGF1, AGT
7vascular endothelial growth factor-activated receptor activityGO:00502110.6NRP1, FLT1
8receptor bindingGO:00510210.5ANGPT2, CXCL12, ADM, TGFB2

Products for genes affiliated with Diabetic Retinopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
43NINDS
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50PubMed
51QIAGEN
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