MCID: DBT011
MIFTS: 66

Diabetic Retinopathy malady

Eye category

Summaries for Diabetic Retinopathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Diabetic retinopathy, ([ˌrɛtnˈɑpəθi]) is retinopathy (damage to the retina) caused by... more...

MalaCards: Diabetic Retinopathy, also known as retinal abnormality - diabetes-related, is related to proliferative diabetic retinopathy and diabetic macular edema. An important gene associated with Diabetic Retinopathy is VEGFA (vascular endothelial growth factor A), and among its related pathways are Signaling by GPCR and Rho Family GTPases. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cellular.

Aliases & Classifications for Diabetic Retinopathy

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

diabetic retinopathy 8 22 10 45 31 61
retinal abnormality - diabetes-related 8
diabetic retinopathy nos 8


External Ids:

Disease Ontology8 DOID:8947
MeSH35 D003930
NCIt40 C34538
ICD9CM27 362.0
ICD1025 H36.0

Related Diseases for Diabetic Retinopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diabetic Retinopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative diabetic retinopathy32.1TGFB2, ADM, VTN, SERPINF1, VCAM1, THBS1
2diabetic macular edema31.2SERPINF1, VEGFA
3diabetic nephropathy30.9ADM, SERPINF1, THBS1, AGT, FLT1, CTGF
4proliferative vitreoretinopathy30.9TGFB2, ADM, VTN, THBS1, FGF2, CTGF
5neovascular glaucoma30.8VEGFA
6blindness30.6SERPINF1, VEGFA, TIMP3
7type 1 diabetes30.5IGF1, IGFBP1, AGT, GAD1
8leukostasis30.5VCAM1, ICAM1
9retinal ischemia30.5HIF1A, VEGFA
10atherosclerosis30.4VTN, SERPINF1, VCAM1, THBS1, CXCL12, FGF2
11type 2 diabetes mellitus30.3ADM, VCAM1, IGF1, IGFBP1, AGT, GAD1
12insulin resistance30.3VCAM1, IGF1, IGFBP1, AGT, CTGF
13vascular disease30.2VTN, VCAM1, FGF2, ANGPT2, VEGFA, AGT
14coronary artery disease,30.2VTN, VCAM1, HIF1A, IGFBP1, AGT, ICAM1
15uveitis30.2TGFB2, SERPINF1, ICAM1
16acromegaly30.2IGF1, IGFBP1
17osteoarthritis30.0TGFB2, VCAM1, THBS1, CXCL12, FGF2, IGF1
18hypoglycemia30.0HIF1A, IGF1, IGFBP1, GAD1
19vascular cancer30.0THBS1, FGF2, VEGFA, FLT1
20coronary heart disease30.0VCAM1, THBS1, AGT
21stroke, ischemic30.0ADM, VCAM1, ICAM1
22nephrosclerosis30.0ADM
23acute leukemia30.0CXCL12
24background diabetic retinopathy10.6
25severe nonproliferative diabetic retinopathy10.5
26diabetic cataract10.5
27vitreous detachment10.5
28somatostatin analog10.5
29diabetes, type 210.4
30ischemic retinopathy10.3
31retinal microaneurysm10.3
32cystoid macular edema10.3
33hypoxia10.3
34rubeosis iridis10.2
35homocysteine plasma level10.2
36retinitis pigmentosa10.1
37diabetic autonomic neuropathy10.1
38autonomic neuropathy10.1
39sleep disorder10.1
40telangiectasis10.1
41vitreous disease10.1
42cataract-glaucoma10.1
43eales disease10.1
44insulin-resistance type b10.1
45autonomic dysfunction10.1
46retinal disease10.0ADM, SERPINF1, VCAM1, FGF2, HIF1A, IGF1
47adenocarcinoma10.0TGFB2, ADM, VTN, SERPINF1, THBS1, CXCL12
48melanoma10.0TGFB2, VTN, SERPINF1, VCAM1, THBS1, FGF2
49ischemia10.0TGFB2, ADM, VTN, CXCL12, FGF2, HIF1A
50squamous cell carcinoma10.0TGFB2, ADM, VTN, SERPINF1, THBS1, CXCL12

Graphical network of the top 20 diseases related to Diabetic Retinopathy:



Diseases related to diabetic retinopathy

Clinical Features for Diabetic Retinopathy

Drugs & Therapeutics for Diabetic Retinopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diabetic Retinopathy

Drug clinical trials:

Search ClinicalTrials for Diabetic Retinopathy

Search NIH Clinical Center for Diabetic Retinopathy

Search CenterWatch for Diabetic Retinopathy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diabetic Retinopathy cell therapies at LifeMap Discovery.

Genetic Tests for Diabetic Retinopathy

Sources:
22GTR
See all sources

Genetic tests related to Diabetic Retinopathy:

id Genetic test Affiliating Genes
1 Diabetic Retinopathy22

Anatomical Context for Diabetic Retinopathy

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Diabetic Retinopathy:
id TissueAnatomical CompartmentCell Relevance
1 EyeOuter Nuclear LayerMature L Cone Cells Potential therapeutic candidate, affected by disease
2 EyeOuter Nuclear LayerMature M Cone Cells Potential therapeutic candidate, affected by disease
3 EyeInner Nuclear LayerMature Muller Glia Cells Affected by disease
4 EyeOuter Nuclear LayerMature Rod Cells Potential therapeutic candidate, affected by disease
5 EyeOuter Nuclear LayerMature S Cone Cells Potential therapeutic candidate, affected by disease

Animal Models for Diabetic Retinopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Diabetic Retinopathy:

37 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076812.3AGT, NRP1, FLT1, GAD1, CTGF, ICAM1
2MP:000538412.3VEGFA, NRP1, FLT1, GAD1, CTGF, ICAM1
3MP:000538712.2VEGFA, AGT, NRP1, FLT1, ICAM1, TIMP3
4MP:000537811.9FLT1, GAD1, CTGF, ICAM1, TIMP3, NRP1
5MP:000538511.9TGFB2, CTGF, FLT1, NRP1, AGT, ANGPT2
6MP:000539711.7TIMP3, ICAM1, FLT1, VEGFA, IGF1, HIF1A
7MP:000536911.6ICAM1, FLT1, AGT, IGF1, HIF1A, FGF2
8MP:000537611.6TIMP3, ICAM1, CTGF, GAD1, AGT, IGF1
9MP:000538111.6ICAM1, CTGF, GAD1, VEGFA, ANGPT2, HIF1A
10MP:000538811.5TIMP3, CTGF, GAD1, VEGFA, IGF1, HIF1A
11MP:000539111.4TIMP3, ANGPT2, HIF1A, FGF2, THBS1, SERPINF1
12MP:000537011.4TIMP3, AGT, VEGFA, IGFBP1, HIF1A, CXCL12
13MP:000538911.2FLT1, VEGFA, THBS1, SERPINF1, TGFB2
14MP:000536711.1TIMP3, AGT, HIF1A, THBS1, ADM, TGFB2
15MP:000287311.1CTGF, GAD1, FLT1, VEGFA, IGF1, HIF1A
16MP:001077111.1TIMP3, CTGF, VEGFA, ANGPT2, HIF1A
17MP:000363111.1GAD1, NRP1, AGT, SERPINF1
18MP:000538211.0TGFB2, HIF1A, VEGFA, NRP1, GAD1, CTGF
19MP:000538011.0CTGF, GAD1, VCAM1, ADM, TGFB2
20MP:000539010.9CTGF, VEGFA, IGF1, FGF2, TGFB2
21MP:000537910.8SERPINF1, ICAM1
22MP:000200610.4ICAM1, IGF1, THBS1

Publications for Diabetic Retinopathy

Sources:
51PubMed
See all sources

Articles related to Diabetic Retinopathy:

(show top 50)    (show all 1604)
idTitleAuthorsYear
1
Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy. (23037145)
2013
2
Lipoxins, resolvins, and protectins in the prevention and treatment of diabetic macular edema and retinopathy. (22677359)
2013
3
A Study of Prevalence and Risk Factors of Diabetic Retinopathy in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION). (24171808)
2013
4
Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes. (23417155)
2013
5
Axial length, retinal function, and oxygen consumption: a potential mechanism for a lower risk of diabetic retinopathy in longer eyes. (24168995)
2013
6
Thrombospondin-1 Deficiency Exacerbates the Pathogenesis of Diabetic Retinopathy. (24224119)
2013
7
Direct effects of PPARI+ agonists on retinal inflammation and angiogenesis may explain how fenofibrate lowers risk of severe proliferative diabetic retinopathy. (23258912)
2013
8
Diabetic retinopathy in sub-Saharan Africa: meeting the challenges of an emerging epidemic. (23819888)
2013
9
Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy. (23559865)
2013
10
Serum lipids and diabetic retinopathy: A cross-sectional study. (23565476)
2012
11
Effects of bevacizumab on the neovascular membrane of proliferative diabetic retinopathy: reduction of endothelial cells and expressions of VEGF and HIF-1I+. (22232563)
2012
12
2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. (22116960)
2012
13
Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy. (22409294)
2012
14
Caspase-14: a novel caspase in the retina with a potential role in diabetic retinopathy. (22876114)
2012
15
Relationship between compliance with ophthalmic examinations preoperatively and visual outcome after vitrectomy for proliferative diabetic retinopathy. (22763797)
2012
16
Intake of Gnetum africanum and Dacryodes edulis, imbalance of oxidant/antioxidant status and prevalence of diabetic retinopathy in central Africans. (23226496)
2012
17
Association between angiotensin-converting enzyme gene polymorphism and diabetic retinopathy in the Chinese population. (22249557)
2012
18
Intraocular VEGF level as a risk factor for postoperative complications after vitrectomy for proliferative diabetic retinopathy. (22899753)
2012
19
Diabetic retinopathy at the YaoundAc Central Hospital in Cameroon: epidemiology and angiographic findings. (23330045)
2012
20
Ophthalmodynamometric pressure in eyes with proliferative diabetic retinopathy measured during pars plana vitrectomy. (21236404)
2011
21
Therapeutic effect of bevacizumab injected into the silicone oil in eyes with neovascular glaucoma after vitrectomy for advanced diabetic retinopathy. (19407842)
2010
22
Strategy for treatment of diabetic retinopathy]. (20387536)
2010
23
Proliferative diabetic retinopathy: predictive and preventive measures at hypoxia induced retinal changes. (23199042)
2010
24
Diabetic retinopathy: Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort. (21067489)
2010
25
Effect of serum cytokines and VEGF levels on diabetic retinopathy and macular thickness. (19784389)
2009
26
Analysis of the clinical efficacy of intravitreal bevacizumab in the treatment of iris neovascularization caused by proliferative diabetic retinopathy. (18803622)
2009
27
Management of diabetic retinopathy: could lipid-lowering be a worthwhile treatment modality? (19169236)
2009
28
Increased levels of monokine induced by interferon-gamma (Mig) in the vitreous of patients with diabetic retinopathy. (18644076)
2008
29
TNF-alpha is an independent serum marker for proliferative retinopathy in type 1 diabetic patients. (18413212)
2008
30
Alteration of timing of secretion of vascular endothelial growth factors is responsible for progression of diabetic retinopathy. (18975510)
2008
31
Changes of plasma endothelin-1 and vascular endothelial growth factor in diabetic retinopathy and the clinical application value thereof]. (18167288)
2007
32
Molecular basis of diabetic retinopathy]. (18097337)
2007
33
Elevation of monocyte-derived microparticles in patients with diabetic retinopathy. (16584800)
2006
34
Lipid peroxidation and antioxidant status in patients with diabetic retinopathy. (16170987)
2005
35
Relation between polymorphisms G1704T and G82S of RAGE gene and diabetic retinopathy in Japanese type 2 diabetic patients. (15942078)
2005
36
Diverse NF-kappaB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopathy. (14737065)
2004
37
Pharmacotherapy for diabetic retinopathy. (15523197)
2004
38
Role of interleukin-1beta in the pathogenesis of diabetic retinopathy. (15377563)
2004
39
Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide. (15544519)
2004
40
Retinal photocoagulation does not influence intraocular levels of IGF-I, IGF-II and IGF-BP3 in proliferative diabetic retinopathy-evidence for combined treatment of PDR with somatostatin analogues and retinal photocoagulation? (11440279)
2001
41
Detection of glutamate and gamma-aminobutyric acid in vitreous of patients with proliferative diabetic retinopathy. (12579648)
2000
42
Sildenafil (Viagra) a cause of proliferative diabetic retinopathy? (11116706)
2000
43
Association between diabetic retinopathy and genetic variations in alpha2beta1 integrin, a platelet receptor for collagen. (10688808)
2000
44
Diabetic retinopathy is associated with decreased serum levels of free IGF-I and changes of IGF-binding proteins. (10753593)
2000
45
Diabetic retinopathy and urinary albumin excretion rate in type II (non-insulin-dependent) diabetic patients. (9151202)
1996
46
Protein composition of the vitreous body in proliferative diabetic retinopathy. An analysis with 2-D-electrophoresis]. (7849428)
1994
47
Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. (7943121)
1994
48
The effect of the aldose reductase inhibitor, ponalrestat, on the progression of diabetic retinopathy. (1611137)
1992
49
The use of the Markov process in describing the natural course of diabetic retinopathy. (2400344)
1990
50
Diabetic retinopathy]. (2237047)
1990

Genetic Variations for Diabetic Retinopathy

Expression for genes affiliated with Diabetic Retinopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diabetic Retinopathy

Search GEO for disease gene expression data for Diabetic Retinopathy.

Pathways for genes affiliated with Diabetic Retinopathy

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 50PharmGKB, 56SinoBiological, 12EMD Millipore
See all sources

Pathways related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6ICAM1, FLT1, NRP1, AGT, VEGFA, IGF1
2
Hide members
11.4TIMP3, CTGF, FLT1, NRP1, ANGPT2, IGF1
311.2TIMP3, VEGFA, IGF1, HIF1A, FGF2, THBS1
4
Hide members
11.2TIMP3, CTGF, FLT1, ANGPT2, IGF1, FGF2
511.1FLT1, VEGFA, ANGPT2, IGF1, FGF2, THBS1
6
Hide members
11.1TIMP3, CTGF, FLT1, NRP1, ANGPT2, IGF1
7
Hide members
11.1TIMP3, CTGF, FLT1, NRP1, FGF2, CXCL12
8
Hide members
11.1TIMP3, CTGF, FLT1, IGF1, FGF2, CXCL12
9
Hide members
11.1TIMP3, CTGF, FLT1, NRP1, IGF1, FGF2
10
Hide members
11.0TIMP3, CTGF, FLT1, NRP1, IGF1, FGF2
1110.9VEGFA, IGFBP1, HIF1A, CXCL12, ADM
12
Hide members
10.9ICAM1, CXCL12, THBS1, VCAM1, VTN
1310.9FLT1, VEGFA, ANGPT2, IGF1, HIF1A
14
Hide members
10.9ANGPT2, AGT, FLT1, CTGF, TIMP3
15
Hide members
10.9FLT1, VEGFA, IGF1, THBS1, VTN
1610.9TIMP3, FLT1, VEGFA, HIF1A, FGF2
1710.9TIMP3, FLT1, ANGPT2, HIF1A, FGF2
18
Hide members
10.9TIMP3, FLT1, NRP1, VEGFA, FGF2
19
Hide members
10.9TIMP3, CTGF, FLT1, NRP1, FGF2
20
Hide members
10.8ICAM1, FGF2, VCAM1, VTN
21
Hide members
10.8ICAM1, NRP1, VEGFA, VCAM1
22
Hide members
10.8TIMP3, CTGF, IGF1, CXCL12
2310.8VEGFA, IGF1, FGF2, THBS1
24
Hide members
10.8FLT1, NRP1, VEGFA, HIF1A
25
Hide members
10.8CTGF, FLT1, NRP1, CXCL12
26
Cell adhesion ECM remodeling
Hide members
10.8VTN, IGF1, TIMP3
2710.8VCAM1, CXCL12, ICAM1
2810.7ICAM1, CTGF, VTN
2910.7IGF1, VEGFA, FLT1
30
Hide members
10.7AGT, NRP1, TIMP3
31
Hide members
10.7VEGFA, NRP1, FLT1
3210.7FGF2, CXCL12, THBS1
3310.7VTN, VEGFA
3410.7IGF1, TIMP3
35
Hide members
10.7THBS1, VEGFA
3610.7FGF2, HIF1A
37
Hide members
10.6IGF1
3810.6FLT1
3910.6NRP1

Compounds for genes affiliated with Diabetic Retinopathy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 173)
idCompoundScoreTop Affiliating Genes
1tyrosine4512.6TIMP3, ICAM1, CTGF, GAD1, FLT1, NRP1
2vegf4512.6TIMP3, ICAM1, FLT1, NRP1, AGT, VEGFA
3phosphatidylinositol4512.5VTN, ADM, TGFB2, VCAM1, THBS1, TIMP3
4nitric oxide45 11 2414.2ICAM1, CTGF, GAD1, FLT1, NRP1, AGT
5cysteine4512.2TIMP3, CTGF, GAD1, NRP1, AGT, ANGPT2
6retinoic acid45 2413.1ICAM1, IGF1, IGFBP1, ANGPT2, CTGF, TIMP3
7glucose4512.1FLT1, NRP1, AGT, ANGPT2, IGF1, HIF1A
8genistein45 29 60 2 11 2417.1TGFB2, VCAM1, THBS1, CXCL12, ICAM1, FLT1
9thymidine45 2413.0HIF1A, FGF2, CXCL12, THBS1, ADM, TGFB2
10ly2940024511.9TIMP3, ICAM1, CTGF, AGT, VEGFA, ANGPT2
11wortmannin4511.9ADM, VTN, TIMP3, NRP1, AGT, ANGPT2
12pd 98,0594511.9THBS1, VCAM1, VTN, CXCL12, FGF2, TIMP3
13dexamethasone45 50 29 1114.9VEGFA, ANGPT2, AGT, CTGF, TIMP3, HIF1A
14sb 20358045 6012.9ICAM1, CTGF, FLT1, AGT, VEGFA, IGF1
15paraffin4511.9TIMP3, ANGPT2, FLT1, AGT, VEGFA, FGF2
16heparin45 29 11 2414.8TIMP3, CTGF, FLT1, NRP1, AGT, VEGFA
17h2o24511.8ADM, SERPINF1, ICAM1, CTGF, GAD1, FLT1
18prostacyclin4511.8ICAM1, CTGF, FLT1, AGT, VEGFA, FGF2
19cholesterol45 29 11 2414.8IGF1, CXCL12, THBS1, VCAM1, VTN, ADM
20arginine4511.8ADM, VCAM1, CXCL12, HIF1A, IGF1, IGFBP1
21calcium45 50 11 2414.8NRP1, TGFB2, IGFBP1, ANGPT2, CXCL12, SERPINF1
22ribonucleic acid4511.8IGF1, IGFBP1, ANGPT2, CXCL12, NRP1, CTGF
23oxygen45 2412.7TIMP3, ICAM1, GAD1, FLT1, AGT, ANGPT2
24hyaluronic acid45 2412.7THBS1, CXCL12, FGF2, VEGFA, NRP1, VCAM1
25lipid4511.7TIMP3, ADM, VTN, FLT1, VCAM1, NRP1
26cyclosporin a45 29 6013.6ICAM1, HIF1A, TGFB2, ADM, THBS1, FGF2
27fibrinogen4511.6THBS1, ICAM1, CTGF, AGT, IGFBP1, ANGPT2
28rapamycin4511.6CXCL12, THBS1, HIF1A, IGFBP1, VEGFA, AGT
29actinomycin d4511.6VEGFA, ADM, ICAM1, AGT, IGFBP1, IGF1
30steroid4511.6NRP1, TGFB2, ADM, CXCL12, IGFBP1, ANGPT2
31glycosaminoglycan4511.6THBS1, FGF2, TIMP3, CXCL12, TGFB2, VTN
32cytochalasin d45 6012.6THBS1, VTN, VCAM1, FGF2, CTGF, ICAM1
33matrigel4511.6NRP1, HIF1A, CXCL12, THBS1, VTN, TGFB2
34progesterone45 60 29 11 2415.5FLT1, TIMP3, GAD1, TGFB2, ADM, THBS1
35n acetylcysteine4511.5ICAM1, TGFB2, SERPINF1, VCAM1, HIF1A, VEGFA
36serine4511.5VTN, FLT1, SERPINF1, THBS1, FGF2, AGT
37tamoxifen45 50 29 1114.4IGFBP1, VCAM1, VTN, THBS1, CXCL12, IGF1
38tgf beta14511.4CTGF, FLT1, THBS1, FGF2, VCAM1, TGFB2
39creatinine4511.4TGFB2, GAD1, FLT1, AGT, IGF1, ANGPT2
40alanine4511.3VCAM1, VTN, IGFBP1, THBS1, FGF2, NRP1
41guanylate4511.2SERPINF1, ANGPT2, NRP1, FLT1, ADM, AGT
42pge24511.1VEGFA, VTN
43cycloheximide4511.0CXCL12, IGFBP1
44hydrocortisone45 2 60 1114.0ADM, IGFBP1, FGF2, FLT1, IGF1
45estradiol45 11 2413.0TGFB2, TIMP3, GAD1
46diphenyleneiodonium4511.0SERPINF1, VCAM1
47l-nmma4510.9ADM, AGT, VCAM1, HIF1A, IGF1
48herbimycin a45 6011.9IGFBP1, FGF2, CXCL12, VCAM1, VTN, ICAM1
49mannitol45 1111.7ICAM1
50cobalt chloride4510.5VEGFA, HIF1A, VCAM1, ADM

GO Terms for genes affiliated with Diabetic Retinopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Diabetic Retinopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561512.0TGFB2, ICAM1, CTGF, FLT1, AGT, VEGFA
2extracellular regionGO:00557611.7IGFBP1, ANGPT2, VEGFA, AGT, NRP1, CTGF
3external side of plasma membraneGO:00989710.8VCAM1, THBS1, CXCL12, ICAM1
4platelet alpha granule lumenGO:03109310.7VEGFA, IGF1, THBS1, TGFB2
5extracellular matrixGO:03101210.6TIMP3, THBS1, SERPINF1, VTN, TGFB2

Biological processes related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.6NRP1, ANGPT2, IGFBP1, IGF1, HIF1A, FGF2
2response to hypoxiaGO:00166611.6VEGFA, ANGPT2, HIF1A, THBS1, VCAM1, ADM
3positive regulation of angiogenesisGO:04576611.6ADM, FLT1, VEGFA, ANGPT2, HIF1A, FGF2
4positive regulation of cell proliferationGO:00828411.6CTGF, FLT1, VEGFA, IGF1, FGF2, ADM
5cell adhesionGO:00715511.4ICAM1, NRP1, CXCL12, THBS1, VCAM1, VTN
6positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.4NRP1, AGT, VEGFA, IGF1, VTN
7angiogenesisGO:00152511.3CTGF, VEGFA, ANGPT2, HIF1A, TGFB2
8extracellular matrix organizationGO:03019811.3AGT, FGF2, THBS1, VTN, TGFB2
9positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094911.3VTN, HIF1A, VEGFA, FLT1
10positive regulation of endothelial cell migrationGO:01059511.3NRP1, AGT, VEGFA, THBS1
11patterning of blood vesselsGO:00156911.3CXCL12, VEGFA, NRP1, FLT1
12negative regulation of cell proliferationGO:00828511.3AGT, IGF1, FGF2, ADM, TGFB2
13positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406811.3FLT1, AGT, IGF1, TGFB2
14response to woundingGO:00961111.3CTGF, NRP1, ADM, TGFB2
15positive regulation of endothelial cell proliferationGO:00193811.3FGF2, HIF1A, VEGFA, NRP1
16platelet degranulationGO:00257611.2VEGFA, IGF1, THBS1, TGFB2
17cell migrationGO:01647711.2CTGF, FLT1, THBS1, TGFB2
18heart developmentGO:00750711.2NRP1, VCAM1, ADM, TGFB2
19positive regulation of smooth muscle cell migrationGO:01491111.2NRP1, IGF1, VTN
20negative regulation of blood vessel endothelial cell migrationGO:04353711.2THBS1, FGF2, ANGPT2
21positive regulation of blood vessel endothelial cell migrationGO:04353611.2THBS1, FGF2, VEGFA
22vascular endothelial growth factor receptor signaling pathwayGO:04801011.1FLT1, NRP1, VEGFA
23positive chemotaxisGO:05091811.1FGF2, VEGFA, NRP1
24blood vessel remodelingGO:00197411.1TGFB2, IGF1, AGT
25outflow tract morphogenesisGO:00315111.1VEGFA, HIF1A, THBS1
26blood coagulationGO:00759611.1VEGFA, ANGPT2, IGF1, THBS1, TGFB2
27positive regulation of cell divisionGO:05178111.1VEGFA, FGF2, TGFB2
28regulation of retinal ganglion cell axon guidanceGO:09025911.0VEGFA, NRP1
29positive regulation of retinal ganglion cell axon guidanceGO:190233611.0VEGFA, NRP1
30negative regulation of angiogenesisGO:01652511.0ANGPT2, THBS1, SERPINF1
31platelet activationGO:03016811.0VEGFA, IGF1, THBS1, TGFB2
32positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141911.0VEGFA, HIF1A
33positive regulation of axon extension involved in axon guidanceGO:04884211.0NRP1, VEGFA
34positive regulation of cerebellar granule cell precursor proliferationGO:02194011.0IGF1, FGF2
35response to glucose stimulusGO:00974911.0CTGF, ANGPT2, THBS1
36regulation of transforming growth factor beta2 productionGO:03290911.0TGFB2, HIF1A
37positive regulation of MAPK cascadeGO:04341011.0FLT1, AGT, IGF1
38embryonic morphogenesisGO:04859811.0FLT1, FGF2
39negative regulation of endopeptidase activityGO:01095111.0AGT, SERPINF1, VTN
40cell adhesion mediated by integrinGO:03362711.0ICAM1, VTN
41membrane to membrane dockingGO:02261411.0ICAM1, VCAM1
42endothelial cell chemotaxisGO:03576710.9VEGFA, NRP1
43commissural neuron axon guidanceGO:07167910.9VEGFA, NRP1
44cell-matrix adhesionGO:00716010.9VTN, AGT, CTGF
45cell-cell signalingGO:00726710.8NRP1, AGT, ADM, TGFB2
46positive regulation of phospholipase C activityGO:01086310.8FGF2, FLT1
47chronic inflammatory responseGO:00254410.7VCAM1, THBS1
48positive regulation of cardiac muscle hypertrophyGO:01061310.7IGF1, AGT
49lung developmentGO:03032410.6FGF2, VEGFA, CTGF
50cellular response to hypoxiaGO:07145610.5ICAM1, VEGFA, HIF1A

Molecular functions related to Diabetic Retinopathy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.0AGT, NRP1, FLT1, GAD1, CTGF, ICAM1
2growth factor activityGO:00808311.3TGFB2, CTGF, AGT, VEGFA, IGF1, FGF2
3integrin bindingGO:00517811.2ICAM1, CTGF, IGF1, THBS1, VCAM1, VTN
4heparin bindingGO:00820111.1CTGF, NRP1, VEGFA, FGF2, THBS1, VTN
5fibronectin bindingGO:00196810.8CTGF, VEGFA, THBS1
6hormone activityGO:00517910.7ADM, IGF1, AGT
7vascular endothelial growth factor-activated receptor activityGO:00502110.6NRP1, FLT1
8receptor bindingGO:00510210.5ANGPT2, CXCL12, ADM, TGFB2

Products for genes affiliated with Diabetic Retinopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diabetic Retinopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet