MCID: DRR001
MIFTS: 54

Diarrhea malady

Summaries for Diarrhea

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Diarrhea means that you have loose, watery stools more than three times in one day. you may also have cramps, bloating, nausea and an urgent need to have a bowel movement. causes of diarrhea include bacteria, viruses or parasites, certain medicines, food intolerances and diseases that affect the stomach, small intestine or colon. in many cases, no cause can be found. although usually not harmful, diarrhea can become dangerous or signal a more serious problem. you should talk to your doctor if you have a strong pain in your abdomen or rectum, a fever, blood in your stools, severe diarrhea for more than three days or symptoms of dehydration. if your child has diarrhea, do not hesitate to call the doctor for advice. diarrhea can be dangerous in children. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diarrhea is related to secretory diarrhea and dysentery. An important gene associated with Diarrhea is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are wtCFTR and deltaF508 traffic / Membrane expression (norm and CF) and Multifunctional anion exchangers. The compounds bicarbonate and chloride have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related mouse phenotypes are mortality/aging and digestive/alimentary.

Disease Ontology:8 Diarrhea is a intestinal disease described as the condition of having frequent loose or liquid bowel movements. acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. the loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. there are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia:63 Diarrhea or diarrhœa (from the Greek διάρροια, δια dia \"through\" + ρέω rheo \"flow\"... more...

Aliases & Classifications for Diarrhea

About this section
Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 56SNOMED-CT, 27ICD9CM, 60UMLS, 34MeSH
See all sources

Aliases & Descriptions:

diarrhea 8 10 33


Related Diseases for Diarrhea

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity family:

Acute Diarrhea Inflammatory Diarrhea
diarrhea

Diseases related to Diarrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 499)
idRelated DiseaseScoreTop Affiliating Genes
1secretory diarrhea31.0GCC1, PDZD3
2dysentery30.6LACTB, LTF
3pancreatitis30.4TMPRSS15, LTF
4cystic fibrosis29.9LACTB, DERL1, GUCY2C, LTF, SLC9A3R2, SLC26A3
5adenocarcinoma29.5SPINT2, SLC26A3, EPCAM, GUCY2C
6acute diarrhea11.1
7syndromic diarrhea10.8
8congenital chloride diarrhea10.7
9irritable bowel syndrome10.6
10functional diarrhea10.5
11cholera10.4
12inflammatory diarrhea10.4
13hemolytic-uremic syndrome10.4
14rhinotracheitis10.4
15microsporidiosis10.4
16osmotic diarrhea10.3
17hypokalemia10.3
18hepatitis10.3
19cryptosporidiosis10.3
20amyloidosis10.2
21islet cell tumor10.2
22celiac disease10.2
23steatorrhea10.2
24ganglioneuroblastoma10.2
25gastroenteritis10.2
26vipoma10.2
27lactose intolerance10.2
28ulcerative colitis10.2
29hepatitis a10.2
30ganglioneuroma10.2
31chronic diarrhea due to guanylate cyclase 2c overactivity10.1
32crohn's disease10.1
33campylobacteriosis10.1
34duodenitis10.1
35acrodermatitis enteropathica10.1
36shigellosis10.1
37adenoma10.1
38pneumonia10.1
39hepatitis c10.1
40giardiasis10.1
41protein-losing enteropathy10.1
42cerebrotendinous xanthomatosis10.1
43metabolic acidosis10.1
44pancreatic cholera10.1
45arthritis10.1
46atypical hemolytic-uremic syndrome10.1
47microvillus inclusion disease10.1
48diarrhea 5, with tufting enteropathy, congenital10.1
49strongyloidiasis10.1
50methemoglobinemia10.1

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to diarrhea

Clinical Features for Diarrhea

About this section

Drugs & Therapeutics for Diarrhea

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diarrhea

Drug clinical trials:

Search ClinicalTrials for Diarrhea

Search NIH Clinical Center for Diarrhea

Search CenterWatch for Diarrhea

Genetic Tests for Diarrhea

About this section

Anatomical Context for Diarrhea

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Diarrhea:

32
Colon, Small intestine, Kidney, Testes, Breast, Pancreas, Liver, T cells, Skin, Pancreatic islet, B cells, Brain, Lung, Appendix, Eye, Monocytes, Bone, Heart, Thyroid, Bone marrow

Animal Models for Diarrhea or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Diarrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.3PITX1, LPAR2, NEUROG3, EPCAM, FGF19, SKIV2L
2MP:000538110.7SLC26A3, KCNN4, GUCY2C, PITX1, NEUROG3, EPCAM

Publications for Diarrhea

About this section
Sources:
50PubMed
See all sources

Articles related to Diarrhea:

(show top 50)    (show all 1655)
idTitleAuthorsYear
1
Effect of constant exposure to cattle persistently infected with bovine viral diarrhea virus on morbidity and mortality rates and performance of feedlot cattle. (24378032)
2014
2
Low vitamin D level is an independent predictor of poor outcomes in Clostridium difficile-associated diarrhea. (24381644)
2014
3
Diarrhea in enterally fed patients: blame the diet? (23799327)
2013
4
The burden of pediatric diarrhea: a cross-sectional study of incurred costs and perceptions of cost among Bolivian families. (23915207)
2013
5
Potential impact of influenza A/H1N1 pandemic and hand-gels on acute diarrhea epidemic in France. (24124479)
2013
6
Does confounding explain the association between PPIs and Clostridium difficile-related diarrhea? (23381076)
2013
7
Effect of rotavirus vaccine on diarrhea mortality in different socioeconomic regions of Mexico. (23460689)
2013
8
Effectiveness of the WC/rBS oral cholera vaccine in the prevention of traveler's diarrhea: A prospective cohort study. (23324573)
2013
9
Porcine epidemic diarrhea virus variants with high pathogenicity, China. (24274832)
2013
10
Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays. (23554205)
2013
11
Changes in blood acid-base balance parameters and coagulation profile during diarrhea in calves. (24195290)
2013
12
Improving pharmacy staff knowledge and practice on childhood diarrhea management in Vietnam: are educational interventions effective? (24098355)
2013
13
Intrauterine foreign body presenting as a rectal bezoar and causing chronic diarrhea. (24285069)
2013
14
Massive infestation with pinworms causing chronicA diarrhea. (23763862)
2013
15
Use of the alpha glucosidase inhibitor acarbose in patients with 'Middleton syndrome': normal gastric anatomy but with accelerated gastric emptying causing postprandial reactive hypoglycemia and diarrhea. (23862171)
2013
16
Seasonal variation of enteropathogens in infants and preschoolers with acute diarrhea in western Mexico. (20706147)
2010
17
Complete Currarino triad presenting with diarrhea in a 7-month-old girl. (20622714)
2010
18
Characterization of human rotavirus recovered from children with acute diarrhea in Kinshasa, Democratic Republic Of Congo. (20684702)
2010
19
An autopsy case of disseminated cryptococcosis manifesting as acute diarrhea in a patient with primary biliary cirrhosis. (20720361)
2010
20
Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. (19820137)
2009
21
Lack of effect of nucleotide-supplemented infant formula on the management of acute diarrhea in infants. (19410975)
2009
22
Prevalence and characteristics of cytolethal distending toxin-producing Escherichia coli from children with diarrhea in Japan. (19714857)
2009
23
Molecular studies of fecal anaerobic commensal bacteria in acute diarrhea in children. (18493205)
2008
24
Dietary intake and clinical response of hospitalized patients with acute diarrhea. (18510202)
2008
25
Prospective multicenter study evaluating fecal calprotectin in adult acute bacterial diarrhea. (19028207)
2008
26
Prevalence of microscopic colitis in patients with diarrhea of unknown etiology in Turkey. (18666319)
2008
27
Detection of Cryptosporidium spp and other intestinal parasites in children with acute diarrhea and severe dehydration in Rio de Janeiro. (17653475)
2007
28
Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone. (16527337)
2006
29
Preventive effects of the probiotic Escherichia coli strain Nissle 1917 on acute secretory diarrhea in a pig model of intestinal infection. (16614995)
2006
30
Microsporidiosis in travel-associated chronic diarrhea in immune-competent patients. (16103591)
2005
31
Current concepts in management of acute diarrhea. (12768058)
2003
32
Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors. (12464662)
2002
33
A prospective case-control study of the role of astrovirus in acute diarrhea among hospitalized young children. (11398103)
2001
34
Treatment of acute diarrhea in the new millennium. (10817275)
2000
35
Presence of diarrhea and absence of tendon xanthomas in patients with cerebrotendinous xanthomatosis. (10768627)
2000
36
Secretory diarrhea. (10980977)
1999
37
Use of undiluted whole cow's milk is effective for the routine treatment of children with acute diarrhea and severe dehydration. (9814379)
1998
38
Collagenous colitis: a cause of chronic diarrhea. (7901984)
1993
39
Treatment of acute diarrhea in children. (1442538)
1992
40
Collagenous colitis as a cause of chronic diarrhea. (1996513)
1991
41
Decrease in serum IgE associated with limited restriction in energy intake to treat toddler's diarrhea. (2017470)
1991
42
Acute diarrhea in adults. Management, with emphasis on oral rehydration therapy. (2587459)
1989
43
Refeeding during recovery from acute diarrhea. (3339504)
1988
44
Nasogastric drip rehydration therapy in acute diarrhea with severe dehydration. (3231493)
1988
45
Secretory diarrhea in mixed connective tissue disease. (3969997)
1985
46
Vibrio vulnificus in sea water: a possible cause of acute diarrhea in man? (4038051)
1985
47
Maternal beliefs regarding diet during acute diarrhea. (7327655)
1981
48
Prolonged intermittent diarrhea after Shiga dysentery: postdysenteric syndrome. (6987740)
1980
49
Immunodeficiency, malabsorption and secretory diarrhea. A new syndrome. (474604)
1979
50
A case of watery diarrhea, hypokalemia and hypercalcemia associated with nonulcerogenic islet cell tumor of the pancreas. (174423)
1975

Genetic Variations for Diarrhea

About this section

Expression for genes affiliated with Diarrhea

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diarrhea

Search GEO for disease gene expression data for Diarrhea.

Pathways for genes affiliated with Diarrhea

About this section
Sources:
53Reactome
See all sources

Pathways related to Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
10.7SLC9A3R2, MYO5B, LPAR2
210.6SLC26A2, SLC26A3

Compounds for genes affiliated with Diarrhea

About this section
Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Diarrhea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bicarbonate4411.0SLC9A3R2, SLC26A2, SLC26A3, LTF
2chloride4411.0KCNN4, GUCY2C, SLC26A3, SLC26A2
3ampicillin44 1111.8LACTB, LTF
4amoxicillin44 49 1112.8LTF, LACTB
5oxalate4410.7LTF, SLC26A2
6ofloxacin44 2 1112.6LTF, LACTB
7ciprofloxacin44 1111.6LACTB, LTF
8metronidazole44 1111.5LTF, LACTB
9clarithromycin44 1111.3LACTB, LTF

GO Terms for genes affiliated with Diarrhea

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1brush borderGO:00590310.6TMPRSS15, PDZD3

Biological processes related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681110.7SLC26A2, SLC26A3, PDZD3
2receptor guanylyl cyclase signaling pathwayGO:00716810.5GUCY2C, PDZD3
3sulfate transportGO:00827210.3SLC26A2, SLC26A3

Molecular functions related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4GCC1, PDZD3, GUCY2C, LPAR2, DERL1, MYO5B
2secondary active sulfate transmembrane transporter activityGO:00827110.3SLC26A2, SLC26A3

Products for genes affiliated with Diarrhea

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diarrhea

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet