MCID: DRR001
MIFTS: 51

Diarrhea malady

Genetic diseases, Gastrointestinal diseases, Rare diseases categories

Summaries for Diarrhea

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Diarrhea means that you have loose, watery stools more than three times in one day. you may also have cramps, bloating, nausea and an urgent need to have a bowel movement. causes of diarrhea include bacteria, viruses or parasites, certain medicines, food intolerances and diseases that affect the stomach, small intestine or colon. in many cases, no cause can be found. although usually not harmful, diarrhea can become dangerous or signal a more serious problem. you should talk to your doctor if you have a strong pain in your abdomen or rectum, a fever, blood in your stools, severe diarrhea for more than three days or symptoms of dehydration. if your child has diarrhea, do not hesitate to call the doctor for advice. diarrhea can be dangerous in children. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diarrhea is related to irritable bowel syndrome and cystic fibrosis. An important gene associated with Diarrhea is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are FGFR ligand binding and activation and FGF signaling pathway. The compounds Hydrogen carbonate and paraffin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Disease Ontology:9 A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. the loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. there are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia:66 Diarrhea or diarrhoea (from the Greek ???????? from ??? dia \"through\" and ??? rheo \"flow\") is the... more...

Aliases & Classifications for Diarrhea

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Sources:
9Disease Ontology, 11DISEASES, 35MedlinePlus, 59SNOMED-CT, 36MeSH, 63UMLS, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

diarrhea 9 11 35


Related Diseases for Diarrhea

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity family:

Inflammatory Diarrhea Acute Diarrhea
diarrhea Diarrhea 7

Diseases related to Diarrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 520)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome30.9LTF, KLB, GUCY2C
2cystic fibrosis30.0GUCY2C, SLC26A3, LTF
3primary biliary cirrhosis29.7LTF, EPCAM
4adenocarcinoma29.6SLC26A3, EPCAM, GUCY2C, SPINT2
5acute diarrhea11.1
6congenital chloride diarrhea10.7
7secretory diarrhea10.7
8blindness10.5
9cholera10.5
10hemolytic-uremic syndrome10.4
11dysentery10.4
12rhinotracheitis10.4
13microsporidiosis10.4
14hypokalemia10.4
15osmotic diarrhea10.4
16microscopic colitis10.4
17functional diarrhea10.4
18syndromic diarrhea10.4
19cryptosporidiosis10.3
20hepatitis10.3
21inflammatory diarrhea10.3
22pancreatitis10.3
23microvillus inclusion disease10.3
24amyloidosis10.3
25islet cell tumor10.3
26collagenous colitis10.3
27celiac disease10.2
28steatorrhea10.2
29gastroenteritis10.2
30carcinoid syndrome10.2
31vipoma10.2
32lactose intolerance10.2
33ganglioneuroblastoma10.2
34ulcerative colitis10.2
35ganglioneuroma10.2
36chronic diarrhea due to guanylate cyclase 2c overactivity10.2
37crohn's disease10.2
38duodenitis10.2
39acrodermatitis enteropathica10.2
40shigellosis10.2
41adenoma10.2
42pneumonia10.2
43hepatitis c10.1
44giardiasis10.1
45cerebrotendinous xanthomatosis10.1
46pancreatic cholera10.1
47metabolic acidosis10.1
48arthritis10.1
49atypical hemolytic-uremic syndrome10.1
50diarrhea 5, with tufting enteropathy, congenital10.1

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to diarrhea

Symptoms for Diarrhea

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Drugs & Therapeutics for Diarrhea

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Diarrhea

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Anatomical Context for Diarrhea

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Sources:
34MalaCards
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MalaCards organs/tissues related to Diarrhea:

34
Colon, Small intestine, Kidney, Skin, Heart, Testes, Breast, Pancreas, T cells, Liver, Pancreatic islet, Brain, B cells, Thyroid, Lung, Bone, Monocytes, Eye, Appendix, Bone marrow

Animal Models for Diarrhea or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diarrhea:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0PITX1, GUCY2C, NEUROG3, KLB
2MP:00053819.0SLC26A3, NEUROG3, EPCAM, GUCY2C, PITX1
3MP:00053798.5PITX1, EPCAM, NEUROG3, KLB, SLC26A3
4MP:00053768.2GUCY2C, TMPRSS15, EPCAM, NEUROG3, KLB, SLC26A3
5MP:00107688.1FGF19, SLC26A3, NEUROG3, EPCAM, GUCY2C, PITX1

Publications for Diarrhea

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53PubMed
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Articles related to Diarrhea:

(show top 50)    (show all 1640)
idTitleAuthorsYear
1
Microarray chip based identification of a mixed infection of bovine herpesvirus 1 and bovine viral diarrhea 2 from Indian cattle. (24026447)
2014
2
Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea. (24315882)
2013
3
Clostridium difficile: a cause of diarrhea in children. (23733223)
2013
4
The maternal self-efficacy scale for preventing early childhood diarrhea: validity and reliability. (23452109)
2013
5
Early childhood diarrhea and cardiometabolic risk factors in adulthood: the Institute of Nutrition of Central America and Panama Nutritional Supplementation Longitudinal Study. (23608305)
2013
6
Probiotics for the prevention of Clostridium difficile-associated diarrhea. (23648956)
2013
7
Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli. (24045466)
2013
8
Oral rehydration salt use and its correlates in low-level care of diarrhea among children under 36a88months old in rural Western China. (23506435)
2013
9
Detection of Bovine viral diarrhea virus-specific neutralizing antibodies in fresh colostrum: a modification of the virus neutralization test. (23417081)
2013
10
Genotypic characterization of enterotoxigenic Escherichia coli strains causing traveler's diarrhea. (23224092)
2013
11
Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction. (23018539)
2012
12
Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus. (22855485)
2012
13
Targeted therapies for diarrhea-predominant irritable bowel syndrome. (22754282)
2012
14
A prospective study of acute diarrhea in a cohort of United States military personnel on deployment to the Multinational Force and Observers, Sinai, Egypt. (21212203)
2011
15
Acute renal replacement therapy in children with diarrhea-associated hemolytic uremic syndrome: a single center 16 years of experience. (21716936)
2011
16
Multisite study of cryptosporidiosis in children with diarrhea in India. (20392919)
2010
17
Seasonal variation of enteropathogens in infants and preschoolers with acute diarrhea in western Mexico. (20706147)
2010
18
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. (19185281)
2009
19
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
20
Acute diarrhea in the adult horse: case example and review. (16627106)
2006
21
Niacin metabolite excretion in alcoholic pellagra and AIDS patients with and without diarrhea. (15325687)
2004
22
Virulence markers and antimicrobial susceptibility of bacteria of the Bacteroides fragilis group isolated from stool of children with diarrhea in SALo Paulo, Brazil. (15273805)
2004
23
Examination of small bowel enzymes in chronic diarrhea. (12519224)
2003
24
Detection, subgroup specificity, and genotype diversity of rotavirus strains in children with acute diarrhea in Paraguay. (11980947)
2002
25
A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. (12385443)
2002
26
Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea. (11524734)
2001
27
Secretory diarrhea. (10980977)
1999
28
Use of undiluted whole cow's milk is effective for the routine treatment of children with acute diarrhea and severe dehydration. (9814379)
1998
29
Zinc deficiency and diarrhea: is uroguanylin the culprit? (9428238)
1998
30
To culture or not to culture: fecal lactoferrin screening for inflammatory bacterial diarrhea. (8815110)
1996
31
Osteopetrosis, anemia, thrombocytopenia, and marrow necrosis in beef calves naturally infected with bovine virus diarrhea virus. (8580185)
1995
32
Evaluation of a simplified HEp-2 cell adherence assay for Escherichia coli isolated from south Indian children with acute diarrhea and controls. (7559981)
1995
33
Relationship between the pharmacokinetics of irinotecan and diarrhea during combination chemotherapy with cisplatin. (7775263)
1995
34
Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children. (8586781)
1995
35
New developments in acute diarrhea. (8055704)
1994
36
Infection, diarrhea, and dysentery caused by Shigella species and Campylobacter jejuni among Guatemalan rural children. (8177630)
1994
37
Diarrhea and autonomic dysfunction in a patient with hexosaminidase B deficiency (Sandhoff disease). (8119549)
1994
38
Mosaic expression of brush-border enzymes in infants with chronic diarrhea and malnutrition. (1355533)
1992
39
The management of acute diarrhea in children: oral rehydration, maintenance, and nutritional therapy. Centers for Disease Control and Prevention. (1435668)
1992
40
Intestinal microsporidiosis as a cause of diarrhea in human immunodeficiency virus-infected patients: a report of 20 cases. (1692561)
1990
41
Diarrhea, fever, paresthesia and shortness of breath. (2123781)
1990
42
Enterotoxins and adhesins of enterotoxigenic Escherichia coli: are they risk factors for acute diarrhea in the community? (1973696)
1990
43
Detection of enterotoxigenic strains of Escherichia coli in children with acute diarrhea. (3334593)
1987
44
The evaluation and management of acute diarrhea. (6730484)
1984
45
The management of intractable diarrhea of infancy with peripheral nutrition utilizing a commercial fat emulsion. (99483)
1978
46
Electrolyte economy and its hormonal regulation in congenital chloride diarrhea. (643381)
1978
47
Infectious bovine rhinotracheitis and bovine virus diarrhea. (777058)
1976
48
Amyloidosis associated with primary agammaglobulinemia, severe diarrhea and familial hypogammaglobulinemia. (4182999)
1969
49
The participation of lactic acid in disturbances of the acid-base balance in acute diarrhea in infants. (5370557)
1969
50
Chronic diarrhea and failure to thrive secondary to ganglioneuroma. (6058798)
1967

Variations for Diarrhea

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Expression for genes affiliated with Diarrhea

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diarrhea

Search GEO for disease gene expression data for Diarrhea.

Pathways for genes affiliated with Diarrhea

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Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5FGF19, KLB
29.5FGF19, KLB
3
Show member pathways
9.1FGF19, KLB, PITX1

Compounds for genes affiliated with Diarrhea

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25HMDB, 46Novoseek
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Compounds related to Diarrhea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Hydrogen carbonate259.8LTF, SLC26A3
2paraffin469.5LTF, EPCAM, GUCY2C
3enterotoxin469.5GUCY2C, PITX1

GO Terms for genes affiliated with Diarrhea

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Products for genes affiliated with Diarrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diarrhea

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet