MCID: DRR001
MIFTS: 49

Diarrhea malady

Summaries for Diarrhea

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Diarrhea means that you have loose, watery stools more than three times in one day. you may also have cramps, bloating, nausea and an urgent need to have a bowel movement. causes of diarrhea include bacteria, viruses or parasites, certain medicines, food intolerances and diseases that affect the stomach, small intestine or colon. in many cases, no cause can be found. although usually not harmful, diarrhea can become dangerous or signal a more serious problem. you should talk to your doctor if you have a strong pain in your abdomen or rectum, a fever, blood in your stools, severe diarrhea for more than three days or symptoms of dehydration. if your child has diarrhea, do not hesitate to call the doctor for advice. diarrhea can be dangerous in children. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diarrhea is related to secretory diarrhea and cystic fibrosis. An important gene associated with Diarrhea is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are wtCFTR and deltaF508 traffic / Membrane expression (norm and CF) and Multifunctional anion exchangers. The compounds bicarbonate and chloride have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and digestive/alimentary.

Disease Ontology:8 Diarrhea is a intestinal disease described as the condition of having frequent loose or liquid bowel movements. acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. the loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. there are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia:64 Diarrhea or diarrhoea (from the Greek διάρροια, δια dia \"through\" + ρέω rheo \"flow\"... more...

Aliases & Classifications for Diarrhea

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 57SNOMED-CT, 27ICD9CM, 61UMLS, 35MeSH
See all sources

Aliases & Descriptions:

diarrhea 8 10 34


Related Diseases for Diarrhea

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the diarrhea 5, with tufting enteropathy, congenital family:

chronic diarrhea due to guanylate cyclase 2c overactivity diarrhea with microvillus atrophy 2
acute diarrhea inflammatory diarrhea
diarrhea chronic diarrhea with villous atrophy
congenital chronic diarrhea with protein-losing enteropathy

Diseases related to Diarrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 468)
idRelated DiseaseScoreTop Affiliating Genes
1secretory diarrhea31.0PDZD3, GCC1
2cystic fibrosis30.0GUCY2C, DERL1, LTF, SLC26A3, SLC9A3R2, LACTB
3adenocarcinoma29.6GUCY2C, EPCAM, SLC26A3, SPINT2
4acute diarrhea11.1
5congenital chloride diarrhea10.7
6irritable bowel syndrome10.6
7clostridium difficile10.6
8cholera10.5
9inflammatory diarrhea10.4
10functional diarrhea10.4
11hemolytic-uremic syndrome10.4
12rhinotracheitis10.4
13n syndrome10.4
14osmotic diarrhea10.4
15hypokalemia10.4
16microscopic colitis10.4
17cryptosporidiosis10.3
18amyloidosis10.3
19carcinoid syndrome10.3
20collagenous colitis10.3
21celiac disease10.2
22steatorrhea10.2
23somatostatin analog10.2
24vipoma10.2
25lactose intolerance10.2
26microvillus inclusion disease10.2
27syndromic diarrhea10.2
28hepatitis d10.2
29ulcerative colitis10.2
30ganglioneuroma10.2
31micro syndrome10.2
32chronic diarrhea due to guanylate cyclase 2c overactivity10.2
33campylobacteriosis10.2
34acrodermatitis enteropathica10.2
35shigellosis10.2
36hepatitis a10.2
37adenoma10.2
38crohn's disease10.1
39giardiasis10.1
40protein-losing enteropathy10.1
41cerebrotendinous xanthomatosis10.1
42metabolic acidosis10.1
43pancreatic cholera10.1
44arthritis10.1
45atypical hemolytic-uremic syndrome10.1
46diarrhea 5, with tufting enteropathy, congenital10.1
47strongyloidiasis10.1
48hepatitis c10.1
49methemoglobinemia10.1
50hepatitis b10.1

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to diarrhea

Clinical Features for Diarrhea

Drugs & Therapeutics for Diarrhea

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Diarrhea

Drug clinical trials:

Search ClinicalTrials for Diarrhea

Search NIH Clinical Center for Diarrhea

Search CenterWatch for Diarrhea

Genetic Tests for Diarrhea

Anatomical Context for Diarrhea

Animal Models for Diarrhea or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Diarrhea:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.3PITX1, LPAR2, NEUROG3, EPCAM, FGF19, SKIV2L
2MP:000538110.7SLC26A3, KCNN4, GUCY2C, PITX1, NEUROG3, EPCAM

Publications for Diarrhea

Sources:
51PubMed
See all sources

Articles related to Diarrhea:

(show top 50)    (show all 1692)
idTitleAuthorsYear
1
The maternal self-efficacy scale for preventing early childhood diarrhea: validity and reliability. (23452109)
2013
2
Probiotics for the prevention of Clostridium difficile-associated diarrhea. (23648956)
2013
3
An unusual cause of secondary capillary leak syndrome in a child: rotavirus diarrhea. (23692840)
2013
4
In vitro neutralization of HoBi-like viruses by antibodies in serum of cattle immunized with inactivated or modified live vaccines of bovine viral diarrhea viruses 1 and 2. (23764273)
2013
5
Case records of the Massachusetts General Hospital. Case 6-2013. A 54-year-old man with recurrent diarrhea. (23425169)
2013
6
Prevalence of Campylobacter spp. relative to other enteric pathogens in grow-finish pigs with diarrhea. (23792232)
2013
7
5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines. (23382968)
2013
8
Effect of rotavirus vaccine on diarrhea mortality in different socioeconomic regions of Mexico. (23460689)
2013
9
Effectiveness of the WC/rBS oral cholera vaccine in the prevention of traveler's diarrhea: A prospective cohort study. (23324573)
2013
10
Porcine epidemic diarrhea virus variants with high pathogenicity, China. (24274832)
2013
11
Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays. (23554205)
2013
12
A double-blind block randomized clinical trial on the effect of zinc as a treatment for diarrhea in neonatal Holstein calves under natural challenge conditions. (24074841)
2013
13
Health care seeking practices of caregivers of children under 5 with diarrhea in two informal settlements in Nairobi, Kenya. (24270995)
2013
14
Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. (24286617)
2013
15
A DNA microarray for the versatile diagnosis of infectious diarrhea. (23758523)
2013
16
Non-polio enteroviruses and their association with acute diarrhea in children in India. (23602838)
2013
17
Generation of a monoclonal antibody to S1 protein of porcine epidemic diarrhea virus. (24111871)
2013
18
Effect of korean herbal medicine combined with a probiotic mixture on diarrhea-dominant irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial. (24381638)
2013
19
Genome Sequence of Bovine Viral Diarrhea Virus Strain 10JJ-SKR, Belonging to Genotype 1d. (23929474)
2013
20
Severe diarrhea in a 4-month-old baby girl with acute gastroenteritis: a case report and review of the literature. (22606438)
2012
21
Clinical predictors and outcome of metabolic acidosis in under-five children admitted to an urban hospital in Bangladesh with diarrhea and pneumonia. (22720060)
2012
22
Radiology case of the month. Nausea, vomiting, and diarrhea in a patient with hepatitis C and acquired immunodeficiency syndrome (AIDS). Diffuse, severe gastric-wall thickening, consistent with edema. (23362596)
2012
23
PFGE, Lior serotype, and antimicrobial resistance patterns among Campylobacter jejuni isolated from travelers and US military personnel with acute diarrhea in Thailand, 1998-2003. (21062505)
2010
24
Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome. (18301926)
2008
25
Reactive arthritis with conjunctivitis, urethritis and diarrhea in a child: immunological study of potential bacterial trigger. (18565268)
2008
26
Involvement of UDP-glucuronosyltransferase activity in irinotecan-induced delayed-onset diarrhea in rats. (17549477)
2008
27
Field evaluation of a rota- and adenovirus immunochromatographic assay using stool samples from children with acute diarrhea in Ghana. (17596373)
2007
28
Microsporidiosis in travel-associated chronic diarrhea in immune-competent patients. (16103591)
2005
29
Diffusely adherent Escherichia coli as a cause of acute diarrhea in young children in Northeast Brazil: a case-control study. (11825986)
2002
30
Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11. (12384538)
2002
31
Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. (12145795)
2002
32
Interruption of transmembrane signaling as a novel antisecretory strategy to treat enterotoxigenic diarrhea. (10224234)
1999
33
Intestinal microsporidiosis in HIV infected patients with chronic diarrhea in Thailand. (10772562)
1998
34
Absorption of nutrients from an energy-dense diet liquefied with amylase from germinated wheat in infants with acute diarrhea. (9106095)
1997
35
Infection and cross-protection studies of winter dysentery and calf diarrhea bovine coronavirus strains in colostrum-deprived and gnotobiotic calves. (8720237)
1996
36
Glucose polymer as a cause of protracted diarrhea in infants with unsuspected congenital sucrase-isomaltase deficiency. (8648532)
1996
37
Phase I trial of the somatostatin analog octreotide acetate in the treatment of fluoropyrimidine-induced diarrhea. (7799023)
1995
38
New developments in acute diarrhea. (8055704)
1994
39
Severe diarrhea and Cushing's syndrome from an atypical bronchial carcinoid. (8052904)
1994
40
Dietary protein intolerance in infants with transient methemoglobinemia and diarrhea. (8419621)
1993
41
Efficacy of the somatostatin analog octreotide in the treatment of two patients with refractory diabetic diarrhea. (8480746)
1993
42
Systemic amyloidosis-induced diarrhea in sex-linked agammaglobulinemia. (8338101)
1993
43
Secretory diarrhea and candidal overgrowth: cause and effect? (1894948)
1991
44
Acute diarrhea in adults. Management, with emphasis on oral rehydration therapy. (2587459)
1989
45
The evaluation and management of acute diarrhea. (6730484)
1984
46
Dietary treatment of acute diarrhea: comparison between cow's milk and a soy formula without disaccharides. (6541707)
1984
47
Severe diarrhea after colonic pseudo-obstruction: treatment with somatostatin. (6141526)
1984
48
Acute diarrhea in horses of the Potomac River area: examination for clostridial toxins. (6469842)
1984
49
Normal jejunal cyclic nucleotide content in a patient with secretory diarrhea. (210731)
1978
50
Watery diarrhea, hypokalemia and achlorhydria associated with pancreatic cholera. Case report. (4344758)
1972

Genetic Variations for Diarrhea

Expression for genes affiliated with Diarrhea

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diarrhea

Search GEO for disease gene expression data for Diarrhea.

Pathways for genes affiliated with Diarrhea

Sources:
54Reactome
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Pathways related to Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
10.7SLC9A3R2, MYO5B, LPAR2
210.6SLC26A2, SLC26A3

Compounds for genes affiliated with Diarrhea

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Diarrhea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bicarbonate4511.0SLC9A3R2, SLC26A2, SLC26A3, LTF
2chloride4511.0KCNN4, GUCY2C, SLC26A3, SLC26A2
3ampicillin45 1111.8LACTB, LTF
4amoxicillin45 50 1112.8LTF, LACTB
5oxalate4510.7LTF, SLC26A2
6ofloxacin45 2 1112.6LTF, LACTB
7ciprofloxacin45 1111.6LACTB, LTF
8metronidazole45 1111.5LTF, LACTB
9clarithromycin45 1111.3LACTB, LTF

GO Terms for genes affiliated with Diarrhea

Sources:
16Gene Ontology
See all sources

Cellular components related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1brush borderGO:00590310.6TMPRSS15, PDZD3

Biological processes related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681110.7SLC26A2, SLC26A3, PDZD3
2receptor guanylyl cyclase signaling pathwayGO:00716810.5GUCY2C, PDZD3
3sulfate transportGO:00827210.3SLC26A2, SLC26A3

Molecular functions related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4GCC1, PDZD3, GUCY2C, LPAR2, DERL1, MYO5B
2secondary active sulfate transmembrane transporter activityGO:00827110.3SLC26A2, SLC26A3

Products for genes affiliated with Diarrhea

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  • Lysates
  • Antibodies

Sources for Diarrhea

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet