MCID: DRR001
MIFTS: 52

Diarrhea malady

Genetic diseases, Gastrointestinal diseases, Rare diseases categories
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Summaries for Diarrhea

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MedlinePlus:33 Diarrhea means that you have loose, watery stools more than three times in one day. you may also have cramps, bloating, nausea and an urgent need to have a bowel movement. causes of diarrhea include bacteria, viruses or parasites, certain medicines, food intolerances and diseases that affect the stomach, small intestine or colon. in many cases, no cause can be found. although usually not harmful, diarrhea can become dangerous or signal a more serious problem. you should talk to your doctor if you have a strong pain in your abdomen or rectum, a fever, blood in your stools, severe diarrhea for more than three days or symptoms of dehydration. if your child has diarrhea, do not hesitate to call the doctor for advice. diarrhea can be dangerous in children. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Diarrhea is related to irritable bowel syndrome and cystic fibrosis. An important gene associated with Diarrhea is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are FGFR ligand binding and activation and FGF signaling pathway. The compounds Hydrogen carbonate and paraffin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Disease Ontology:8 A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. the loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. there are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia:65 Diarrhea or diarrhoea (from the Ancient Greek ???????? from ??? dia \"through\" and ??? rheo \"flow\")... more...

Aliases & Classifications for Diarrhea

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Diarrhea, Aliases & Descriptions:

Name: Diarrhea 8 10 33


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Gastrointestinal diseases


Related Diseases for Diarrhea

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Diseases in the Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity family:

Inflammatory Diarrhea Acute Diarrhea
diarrhea Diarrhea 7

Diseases related to Diarrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 537)
idRelated DiseaseScoreTop Affiliating Genes
1irritable bowel syndrome30.9GUCY2C, KLB, LTF
2cystic fibrosis30.1GUCY2C, SLC26A3, LTF
3primary biliary cirrhosis29.9LTF, EPCAM
4adenocarcinoma29.4SPINT2, GUCY2C, EPCAM, SLC26A3
5acute diarrhea11.1
6congenital chloride diarrhea10.8
7secretory diarrhea10.7
8colitis10.6
9blindness10.5
10cholera10.5
11hemolytic-uremic syndrome10.5
12dysentery10.5
13rhinotracheitis10.4
14microscopic colitis10.4
15hypokalemia10.4
16microsporidiosis10.4
17syndromic diarrhea10.4
18osmotic diarrhea10.4
19microvillus inclusion disease10.4
20cryptosporidiosis10.4
21functional diarrhea10.4
22hepatitis10.4
23inflammatory diarrhea10.3
24pancreatitis10.3
25islet cell tumor10.3
26collagenous colitis10.3
27amyloidosis10.3
28gastroenteritis10.3
29carcinoid syndrome10.3
30celiac disease10.3
31ulcerative colitis10.3
32steatorrhea10.3
33ganglioneuroblastoma10.3
34vipoma10.2
35chronic diarrhea due to guanylate cyclase 2c overactivity10.2
36ganglioneuroma10.2
37lactose intolerance10.2
38duodenitis10.2
39crohn's disease10.2
40acrodermatitis enteropathica10.2
41metabolic acidosis10.2
42adenoma10.2
43pneumonia10.2
44atypical hemolytic-uremic syndrome10.2
45primary sclerosing cholangitis10.2EPCAM, LTF
46arthritis10.1
47pancreatic cholera10.1
48hepatitis c10.1
49cerebrotendinous xanthomatosis10.1
50shigellosis10.1

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to diarrhea

Symptoms for Diarrhea

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Drugs & Therapeutics for Diarrhea

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Drug clinical trials:

Search ClinicalTrials for Diarrhea

Search NIH Clinical Center for Diarrhea

Genetic Tests for Diarrhea

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Anatomical Context for Diarrhea

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MalaCards organs/tissues related to Diarrhea:

32
Colon, Small intestine, Kidney, Skin, Heart, Breast, Testes, Pancreas, Liver, T cells, Pancreatic islet, Neutrophil, Brain, Bone marrow, Eye, Bone, Lung, Thyroid, Prostate, Monocytes, B cells, Appendix

Animal Models for Diarrhea or affiliated genes

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MGI Mouse Phenotypes related to Diarrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0PITX1, GUCY2C, NEUROG3, KLB
2MP:00053819.0SLC26A3, NEUROG3, EPCAM, GUCY2C, PITX1
3MP:00053798.5PITX1, EPCAM, NEUROG3, KLB, SLC26A3
4MP:00053768.2GUCY2C, TMPRSS15, EPCAM, NEUROG3, KLB, SLC26A3
5MP:00107688.1FGF19, SLC26A3, NEUROG3, EPCAM, GUCY2C, PITX1

Publications for Diarrhea

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Articles related to Diarrhea:

(show top 50)    (show all 1692)
idTitleAuthorsYear
1
Microarray chip based identification of a mixed infection of bovine herpesvirus 1 and bovine viral diarrhea 2 from Indian cattle. (24026447)
2014
2
Cryptosporidiosis causing severe persistent diarrhea in a patient with multiple myeloma: A Case report and brief review of literature. (25006294)
2014
3
Case 25-2014: A man with ulcerative colitis and bloody diarrhea. (25372108)
2014
4
Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea. (24315882)
2013
5
The maternal self-efficacy scale for preventing early childhood diarrhea: validity and reliability. (23452109)
2013
6
Early childhood diarrhea and cardiometabolic risk factors in adulthood: the Institute of Nutrition of Central America and Panama Nutritional Supplementation Longitudinal Study. (23608305)
2013
7
Influence of acupuncture stimulation on cerebral network in functional diarrhea. (24459533)
2013
8
Probiotics for the prevention of Clostridium difficile-associated diarrhea. (23648956)
2013
9
Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli. (24045466)
2013
10
Oral rehydration salt use and its correlates in low-level care of diarrhea among children under 36a88months old in rural Western China. (23506435)
2013
11
Detection of Bovine viral diarrhea virus-specific neutralizing antibodies in fresh colostrum: a modification of the virus neutralization test. (23417081)
2013
12
Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction. (23018539)
2012
13
Acute diarrhea in West African children: diverse enteric viruses and a novel parvovirus genus. (22855485)
2012
14
Targeted therapies for diarrhea-predominant irritable bowel syndrome. (22754282)
2012
15
A prospective study of acute diarrhea in a cohort of United States military personnel on deployment to the Multinational Force and Observers, Sinai, Egypt. (21212203)
2011
16
Acute renal replacement therapy in children with diarrhea-associated hemolytic uremic syndrome: a single center 16 years of experience. (21716936)
2011
17
Multisite study of cryptosporidiosis in children with diarrhea in India. (20392919)
2010
18
Seasonal variation of enteropathogens in infants and preschoolers with acute diarrhea in western Mexico. (20706147)
2010
19
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. (19185281)
2009
20
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. (17549631)
2008
21
Acute diarrhea in the adult horse: case example and review. (16627106)
2006
22
Niacin metabolite excretion in alcoholic pellagra and AIDS patients with and without diarrhea. (15325687)
2004
23
Virulence markers and antimicrobial susceptibility of bacteria of the Bacteroides fragilis group isolated from stool of children with diarrhea in SALo Paulo, Brazil. (15273805)
2004
24
Examination of small bowel enzymes in chronic diarrhea. (12519224)
2003
25
Detection, subgroup specificity, and genotype diversity of rotavirus strains in children with acute diarrhea in Paraguay. (11980947)
2002
26
A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. (12385443)
2002
27
Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea. (11524734)
2001
28
Secretory diarrhea. (10980977)
1999
29
Use of undiluted whole cow's milk is effective for the routine treatment of children with acute diarrhea and severe dehydration. (9814379)
1998
30
Zinc deficiency and diarrhea: is uroguanylin the culprit? (9428238)
1998
31
To culture or not to culture: fecal lactoferrin screening for inflammatory bacterial diarrhea. (8815110)
1996
32
Osteopetrosis, anemia, thrombocytopenia, and marrow necrosis in beef calves naturally infected with bovine virus diarrhea virus. (8580185)
1995
33
Evaluation of a simplified HEp-2 cell adherence assay for Escherichia coli isolated from south Indian children with acute diarrhea and controls. (7559981)
1995
34
Relationship between the pharmacokinetics of irinotecan and diarrhea during combination chemotherapy with cisplatin. (7775263)
1995
35
Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children. (8586781)
1995
36
New developments in acute diarrhea. (8055704)
1994
37
Infection, diarrhea, and dysentery caused by Shigella species and Campylobacter jejuni among Guatemalan rural children. (8177630)
1994
38
Diarrhea and autonomic dysfunction in a patient with hexosaminidase B deficiency (Sandhoff disease). (8119549)
1994
39
Mosaic expression of brush-border enzymes in infants with chronic diarrhea and malnutrition. (1355533)
1992
40
The management of acute diarrhea in children: oral rehydration, maintenance, and nutritional therapy. Centers for Disease Control and Prevention. (1435668)
1992
41
Intestinal microsporidiosis as a cause of diarrhea in human immunodeficiency virus-infected patients: a report of 20 cases. (1692561)
1990
42
Diarrhea, fever, paresthesia and shortness of breath. (2123781)
1990
43
Enterotoxins and adhesins of enterotoxigenic Escherichia coli: are they risk factors for acute diarrhea in the community? (1973696)
1990
44
Detection of enterotoxigenic strains of Escherichia coli in children with acute diarrhea. (3334593)
1987
45
The management of intractable diarrhea of infancy with peripheral nutrition utilizing a commercial fat emulsion. (99483)
1978
46
Electrolyte economy and its hormonal regulation in congenital chloride diarrhea. (643381)
1978
47
Infectious bovine rhinotracheitis and bovine virus diarrhea. (777058)
1976
48
Amyloidosis associated with primary agammaglobulinemia, severe diarrhea and familial hypogammaglobulinemia. (4182999)
1969
49
The participation of lactic acid in disturbances of the acid-base balance in acute diarrhea in infants. (5370557)
1969
50
Chronic diarrhea and failure to thrive secondary to ganglioneuroma. (6058798)
1967

Variations for Diarrhea

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Expression for genes affiliated with Diarrhea

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Expression patterns in normal tissues for genes affiliated with Diarrhea

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Pathways for genes affiliated with Diarrhea

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Pathways related to Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5FGF19, KLB
29.5FGF19, KLB
3
Show member pathways
9.1FGF19, KLB, PITX1

Compounds for genes affiliated with Diarrhea

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Sources:
24HMDB, 44Novoseek
See all sources

Compounds related to Diarrhea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Hydrogen carbonate249.8LTF, SLC26A3
2paraffin449.5LTF, EPCAM, GUCY2C
3enterotoxin449.5GUCY2C, PITX1

GO Terms for genes affiliated with Diarrhea

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Products for genes affiliated with Diarrhea

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  • Antibodies
  • Proteins
  • Lysates

Sources for Diarrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet