MCID: DRR001
MIFTS: 54

Diarrhea malady

Summaries for Diarrhea

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Diarrhea means that you have loose, watery stools more than three times in one day. you may also have cramps, bloating, nausea and an urgent need to have a bowel movement. causes of diarrhea include bacteria, viruses or parasites, certain medicines, food intolerances and diseases that affect the stomach, small intestine or colon. in many cases, no cause can be found. although usually not harmful, diarrhea can become dangerous or signal a more serious problem. you should talk to your doctor if you have a strong pain in your abdomen or rectum, a fever, blood in your stools, severe diarrhea for more than three days or symptoms of dehydration. if your child has diarrhea, do not hesitate to call the doctor for advice. diarrhea can be dangerous in children. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Diarrhea is related to secretory diarrhea and dysentery. An important gene associated with Diarrhea is SLC26A3 (solute carrier family 26 (anion exchanger), member 3), and among its related pathways are wtCFTR and deltaF508 traffic / Membrane expression (norm and CF) and Multifunctional anion exchangers. The compounds bicarbonate and chloride have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related mouse phenotypes are mortality/aging and digestive/alimentary.

Disease Ontology:8 Diarrhea is a intestinal disease described as the condition of having frequent loose or liquid bowel movements. acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. the loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. there are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea.

Wikipedia:63 Diarrhea or diarrhœa (from the Greek διάρροια, δια dia \"through\" + ρέω rheo \"flow\"... more...

Aliases & Classifications for Diarrhea

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 56SNOMED-CT, 27ICD9CM, 60UMLS, 34MeSH
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Aliases & Descriptions:

diarrhea 8 10 33


Related Diseases for Diarrhea

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17GeneCards, 18GeneDecks
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Diseases in the Chronic Diarrhea Due to Guanylate Cyclase 2c Overactivity family:

Acute Diarrhea Inflammatory Diarrhea
diarrhea

Diseases related to Diarrhea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 499)
idRelated DiseaseScoreTop Affiliating Genes
1secretory diarrhea31.0GCC1, PDZD3
2dysentery30.6LACTB, LTF
3pancreatitis30.4TMPRSS15, LTF
4cystic fibrosis29.9LACTB, DERL1, GUCY2C, LTF, SLC9A3R2, SLC26A3
5adenocarcinoma29.5SPINT2, SLC26A3, EPCAM, GUCY2C
6acute diarrhea11.1
7syndromic diarrhea10.8
8congenital chloride diarrhea10.7
9irritable bowel syndrome10.6
10functional diarrhea10.5
11cholera10.4
12inflammatory diarrhea10.4
13hemolytic-uremic syndrome10.4
14rhinotracheitis10.4
15microsporidiosis10.4
16osmotic diarrhea10.3
17hypokalemia10.3
18hepatitis10.3
19cryptosporidiosis10.3
20amyloidosis10.2
21islet cell tumor10.2
22celiac disease10.2
23steatorrhea10.2
24ganglioneuroblastoma10.2
25gastroenteritis10.2
26vipoma10.2
27lactose intolerance10.2
28ulcerative colitis10.2
29hepatitis a10.2
30ganglioneuroma10.2
31chronic diarrhea due to guanylate cyclase 2c overactivity10.1
32crohn's disease10.1
33campylobacteriosis10.1
34duodenitis10.1
35acrodermatitis enteropathica10.1
36shigellosis10.1
37adenoma10.1
38pneumonia10.1
39hepatitis c10.1
40giardiasis10.1
41protein-losing enteropathy10.1
42cerebrotendinous xanthomatosis10.1
43metabolic acidosis10.1
44pancreatic cholera10.1
45arthritis10.1
46atypical hemolytic-uremic syndrome10.1
47microvillus inclusion disease10.1
48diarrhea 5, with tufting enteropathy, congenital10.1
49strongyloidiasis10.1
50methemoglobinemia10.1

Graphical network of the top 20 diseases related to Diarrhea:



Diseases related to diarrhea

Clinical Features for Diarrhea

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Drugs & Therapeutics for Diarrhea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Diarrhea

Drug clinical trials:

Search ClinicalTrials for Diarrhea

Search NIH Clinical Center for Diarrhea

Search CenterWatch for Diarrhea

Genetic Tests for Diarrhea

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Anatomical Context for Diarrhea

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32MalaCards
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MalaCards organs/tissues related to Diarrhea:

32
Colon, Small intestine, Kidney, Testes, Breast, Pancreas, Liver, T cells, Pancreatic islet, Skin, B cells, Brain, Appendix, Bone, Heart, Eye, Monocytes, Lung, Bone marrow, Thyroid

Animal Models for Diarrhea or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diarrhea:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.3PITX1, LPAR2, NEUROG3, EPCAM, FGF19, SKIV2L
2MP:000538110.7SLC26A3, KCNN4, GUCY2C, PITX1, NEUROG3, EPCAM

Publications for Diarrhea

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50PubMed
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Articles related to Diarrhea:

(show top 50)    (show all 1655)
idTitleAuthorsYear
1
Rotavirus genotypes associated with acute diarrhea in egyptian infants. (24343617)
2014
2
Diarrhea is more dangerous than AIDS in the 21st century. (24290607)
2014
3
Early childhood diarrhea and cardiometabolic risk factors in adulthood: the Institute of Nutrition of Central America and Panama Nutritional Supplementation Longitudinal Study. (23608305)
2013
4
Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli. (24045466)
2013
5
Sociocultural determinants of anticipated vaccine acceptance for acute watery diarrhea in early childhood in Katanga Province, Democratic Republic of Congo. (23878187)
2013
6
Ciprofloxacin reduces the risk of hemolytic uremic syndrome in patients with Escherichia coli O104:H4-associated diarrhea. (23292662)
2013
7
Apparent and content validation of maternal self-efficiency scale for prevention of childhood diarrhea. (23546321)
2013
8
Congenital chloride diarrhea: a review of twelve Arabian children. (23776341)
2013
9
Is fidaxomicin the drug of choice for treating Clostridium difficile-associated diarrhea in patients with cancer? (24166524)
2013
10
Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. (24286617)
2013
11
A novel prion disease associated with diarrhea and autonomic neuropathy. (24224623)
2013
12
Serological and molecular evidence for natural infection of Bactrian camels with multiple subgenotypes of bovine viral diarrhea virus in Western China. (23313538)
2013
13
Health care use patterns for diarrhea in children in low-income periurban communities of Karachi, Pakistan. (23629928)
2013
14
Complete Genome Sequence of a Very Virulent Porcine Epidemic Diarrhea Virus Strain, CH/GDGZ/2012, Isolated in Southern China. (23969052)
2013
15
An Adult Mouse Model of Vibrio cholerae-induced Diarrhea for Studying Pathogenesis and Potential Therapy of Cholera. (23826402)
2013
16
Enteric pathogens, immune status and therapeutic response in diarrhea in HIV/AIDS adult subjects from north India. (23968293)
2013
17
Acute diarrhea among military recruits. (23214210)
2012
18
Indian Medical Association and Unicef: Prevention and treatment of childhood diarrhea. Diarrhea prevention and control need for integrated approaches. (23360034)
2012
19
Antibiotic-prescribing practices of primary care prescribers for acute diarrhea in New Delhi, India. (22265057)
2012
20
A KlothoI^ variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea. (21396369)
2011
21
The optimal use of probiotics in acute diarrhea of childhood. (20060124)
2010
22
A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. (19426836)
2009
23
Hypokalemic rhabdomyolysis due to watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome caused by vipoma. (19488018)
2009
24
Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea. (18942765)
2009
25
Concomitant rotavirus and Salmonella infections in children with acute diarrhea. (19326832)
2009
26
Unusual cause of diarrhea: cronkhite-Canada syndrome. (18356114)
2008
27
Investigation of cryptosporidiosis by enzyme-linked immunosorbent assay and microscopy in children with diarrhea. (18382792)
2008
28
Which adults with acute diarrhea should be evaluated? What is the best diagnostic approach? (15529483)
2004
29
Severe acute diarrhea. (14696306)
2003
30
Protein-losing enteropathy in a young African-American woman with abdominal pain, diarrhea and hydronephrosis. (11787872)
2001
31
Intestinal microsporidiosis in HIV infected patients with chronic diarrhea in Thailand. (10772562)
1998
32
Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. (9586761)
1998
33
Incidence and risk factors for carbohydrate intolerance in Thai infants with acute diarrhea: an outpatient-based study. (9253885)
1996
34
Zinc supplementation reduces the incidence of persistent diarrhea and dysentery among low socioeconomic children in India. (8632217)
1996
35
Congenital chloride diarrhea in a Turkish boy. (8701491)
1996
36
Evaluation of a simplified HEp-2 cell adherence assay for Escherichia coli isolated from south Indian children with acute diarrhea and controls. (7559981)
1995
37
Modern management of acute diarrhea and dehydration in children. (7709888)
1995
38
A pharmacological approach to secretory diarrhea. (7743122)
1995
39
Severe diarrhea and Cushing's syndrome from an atypical bronchial carcinoid. (8052904)
1994
40
Parotitis in diarrhea-associated hemolytic uremic syndrome. (8451109)
1993
41
The somatostatin analog octreotide in the management of the secretory diarrhea of the acute intestinal graft-versus-host disease in a patient after bone marrow transplantation. (2360261)
1990
42
Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. (2795459)
1989
43
Thyrotoxicosis presenting with secretory diarrhea. (3089089)
1986
44
Severe diarrhea after colonic pseudo-obstruction: treatment with somatostatin. (6141526)
1984
45
Congenital dysautonomia with secretory diarrhea. (6578316)
1983
46
Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. (7227779)
1981
47
Intractable diarrhea in a boy with vasoactive intestinal peptide-producing ganglioneuroblastoma. (854377)
1977
48
Epidemiological observations on bovine viral diarrhea-mucosal disease virus-induced congenital cerebellar hypoplasia and ocular defects in calves. (4986633)
1970
49
Enteroanastomosis with partial gastrectomy in treatment of postcibal symptoms. Protection against dumping syndrome and diarrhea. (5916958)
1966
50
Spectrum of acute diarrhea in a general hospital. 4. "Antibiotic bowel" and pseudomembranous enterocolitis. (5827657)
1965

Genetic Variations for Diarrhea

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Expression for genes affiliated with Diarrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diarrhea

Search GEO for disease gene expression data for Diarrhea.

Pathways for genes affiliated with Diarrhea

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53Reactome
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Pathways related to Diarrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
10.7SLC9A3R2, MYO5B, LPAR2
210.6SLC26A2, SLC26A3

Compounds for genes affiliated with Diarrhea

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44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Diarrhea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bicarbonate4411.0LTF, SLC26A3, SLC26A2, SLC9A3R2
2chloride4411.0SLC26A2, GUCY2C, SLC26A3, KCNN4
3ampicillin44 1111.8LTF, LACTB
4amoxicillin44 49 1112.8LTF, LACTB
5oxalate4410.7SLC26A2, LTF
6ofloxacin44 2 1112.6LACTB, LTF
7ciprofloxacin44 1111.6LTF, LACTB
8metronidazole44 1111.5LTF, LACTB
9clarithromycin44 1111.3LACTB, LTF

GO Terms for genes affiliated with Diarrhea

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16Gene Ontology
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Cellular components related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1brush borderGO:00590310.6TMPRSS15, PDZD3

Biological processes related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ion transportGO:00681110.7SLC26A2, SLC26A3, PDZD3
2receptor guanylyl cyclase signaling pathwayGO:00716810.5GUCY2C, PDZD3
3sulfate transportGO:00827210.3SLC26A2, SLC26A3

Molecular functions related to Diarrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.4KCNN4, GCC1, PDZD3, GUCY2C, LPAR2, DERL1
2secondary active sulfate transmembrane transporter activityGO:00827110.3SLC26A3, SLC26A2

Products for genes affiliated with Diarrhea

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  • Antibodies

Sources for Diarrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet