Diastolic Heart Failure malady

Wikipedia: Diastolic heart failure or diastolic dysfunction refers to decline in performance of one (usually the...⁴⁴ more...

MalaCards: Diastolic Heart Failure, also known as heart failure, diastolic, is related to hypertension and atrial fibrillation. An important gene associated with Diastolic Heart Failure is MURC (muscle-related coiled-coil protein), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Glioma Invasiveness. The compounds phenylephrine and pravastatin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Descriptions:

diastolic heart failure 6 8 heart failure, diastolic 43

Diseases related to diastolic heart failure by text searches and GeneDecks gene sharing:

(show top 50)    (show all 320)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	29.4	NOS3, ACE, AGT, AGTR1
2	atrial fibrillation	25.2	MMP1, MMP2, MMP9, ANKRD1, NOS3, ACE
3	cardiac rupture	13.2	MMP9, NPPB
4	renal tubular dysgenesis	13.1	ACE, AGT, AGTR1
5	posterior urethral valves	13.1	ACE, AGT, AGTR1
6	anuria	13.1	ACE, AGT, AGTR1
7	fibromuscular dysplasia	13.1	ACE, AGT, AGTR1
8	interstitial nephritis	13.1	ACE, AGT, AGTR1
9	otosclerosis	13.1	ACE, AGT, AGTR1
10	pulmonary plasma cell granuloma	13.0	BMP6, AGT, PVALB
11	vesicoureteral reflux	13.0	ACE, AGT, AGTR1
12	pre-eclampsia	13.0	NOS3, AGT
13	thoracic aortic aneurysm	13.0	MMP1, MMP2
14	urethritis	12.9	ACE, AGT, AGTR1
15	microcystic meningioma	12.9	MMP2, MMP9
16	lentigo maligna melanoma	12.9	MMP2, MMP9
17	malignant hypertension	12.9	ACE, AGT, AGTR1, NPPB
18	ureteral obstruction	12.9	BMP6, MAPK8, AGTR1
19	oligohydramnios	12.9	ACE, AGT, AGTR1, NPPB
20	mitral valve stenosis	12.9	NPPA, NPPB
21	fibromatosis, gingival	12.9	MMP1, MMP2
22	mitral valve insufficiency	12.9	NPPA, NPPB
23	hepatocellular carcinoma (fibrolamellar variant)	12.9	MMP2, MMP9
24	gitelman syndrome	12.8	NOS3, AGT, PVALB
25	postural orthostatic tachycardia syndrome	12.8	NOS3, AGT, AGTR1
26	marfan syndrome	12.8	BMP6, MMP2, AGTR1
27	subacute sclerosing panencephalitis	12.8	MMP9, ACE, AGTR1
28	coronary stenosis	12.8	NOS3, ACE, NPPB
29	heart valve disease	12.8	NPPA, NPPB
30	cerebral amyloid angiopathy	12.8	MMP9, ACE, CST3
31	endocardial fibroelastosis	12.8	NPPA, NPPB
32	acute mountain sickness	12.8	NOS3, ACE, AGTR1
33	short limb dwarf edema iris coloboma	12.8	NPPA, NPPB
34	keloids	12.8	BMP6, MMP1, MAPK8
35	hypoglycemia	12.8	ACE, AGT, AGTR1, NPPB
36	myostatin-related muscle hypertrophy	12.7	BMP6, MAPK8, AGT
37	tongue cancer	12.7	MMP2, MMP9
38	iga glomerulonephritis	12.7	BMP6, ACE, AGT, AGTR1
39	hypoaldosteronism	12.7	ACE, NPPA
40	corneal ulcer	12.7	MMP2, MMP9
41	focal segmental glomerulosclerosis	12.7	BMP6, ACE, AGT, AGTR1
42	glomerulopathy	12.7	BMP6, ACE, AGT, AGTR1
43	anoxia	12.7	MMP1, CYBB, AGT
44	polycystic kidney disease, autosomal dominant	12.7	NOS3, ACE, CST3
45	oral submucous fibrosis	12.7	MMP1, MMP2, CST3
46	aortic valve stenosis	12.7	AGT, NPPA, NPPB
47	pelvic inflammatory disease	12.6	MMP2, MMP9, CST3
48	klatskin's tumor	12.6	MMP2, MMP9
49	thrombophilia	12.6	NOS3, ACE, AGT
50	intestinal neoplasm	12.6	BMP6, MMP2, MMP9

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to diastolic heart failure:

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MGI Mouse Phenotypes related to diastolic heart failure:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	8.8	NPPA, AGTR1, AGT, NOS3, CYBB
2	homeostasis/metabolism phenotype	MP:0005376	7.9	CST3, AGT, NOS3, CYBB, MAPK8, MMP2
3	tumorigenesis	MP:0002006	7.6	CST3, ACE, CYBB, MAPK8, MMP9, MMP2
4	muscle phenotype	MP:0005369	6.7	MMP2, NPPB, NPPA, CST3, PVALB, AGT
5	cardiovascular system phenotype	MP:0005385	6.3	AGTR1, CST3, NPPA, NPPB, AGT, ACE

Articles related to diastolic heart failure:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	Usefulness of basal B-type natriuretic peptide levels for the diagnosis of diastolic heart failure in young patients: an echocardiog raphic-catheterization study. (19394710)	Arques S.... Paganelli F.	2010	NPPB
2	Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure. (19255799)	Westermann D.... TschAPpe C.	2009	MAPK8, NOS3, CYBB
3	Genetic polymorphisms of the angiotensin II type 1 receptor gene and diastolic heart failure. (19330904)	Wu C.K.... Chiang F.T.	2009	AGTR1
4	Cystatin C concentration as a predictor of systolic and diastolic heart failure. (18226769)	Moran A.... Shlipak M.G.	2008	CST3
5	Optimal noninvasive assessment of diastolic heart failure in patients with atrial fibrillation: comparison of tissue doppler echocardiography, left atrium size, and brain natriuretic peptide. (17904810)	Watanabe T.... Maruyama Y.	2008	NPPB
6	Renin-angiotensin system gene polymorphisms and diastolic heart failure. (19021695)	Wu C.K.... Chiang F.T.	2008	ACE, AGTR1, AGT
7	A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure. (19185300)	Wu C.K.... Chiang F.T.	2008	ACE, AGTR1, AGT
8	Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. (17283265)	Martos R.... McDonald K.	2007	MMP2, MMP9, MMP1
9	Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat. (17716638)	Connelly K.A.... Gilbert R.E.	2007	BMP6
10	Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure. (16628020)	Aronow W.S.	2006	ACE
11	Differential atrial versus ventricular ANKRD1 gene expression is oppositely regulated at diastolic heart failure. (16828759)	Torrado M.... Mikhailov A.T.	2006	ANKRD1
12	B-type natriuretic peptide and tissue Doppler study findings in elderly patients hospitalized for acute diastolic heart failure. (15979445)	Arques S.... Luccioni R.	2005	NPPB
13	Drug treatment of systolic and of diastolic heart failure in elderly persons. (16424295)	Aronow W.S.	2005	ACE
14	Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. (14715184)	Yamaguchi H.... Masuyama T.	2004	NPPB
15	Response of B-type natriuretic peptide to exercise in hypertensive patients with suspected diastolic heart failure: correlation with cardiac function, hemodynamics, and workload. (15309010)	Mottram P.M.... Marwick T.H.	2004	NPPB
16	Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure in elderly patients. (12877761)	Aronow W.S.	2003	ACE
17	Temocapril prevents transition to diastolic heart failure in rats even if initiated after appearance of LV hypertrophy and diastolic dysfunction. (12618237)	Sakata Y.... Masuyama T.	2003	ACE
18	Left ventricular diastolic heart failure with normal left ventricular systolic function in older persons. (11329528)	Aronow W.S.	2001	ACE, AGTR1
19	The changes of PRA, ATII, ald, ET and ANP in patient s with left ventricular diastolic heart failure and intervention with enalapril (9868087)	Zhuang H.... He J.	1997	NPPA
20	Effects of brain natriuretic peptide on exercise hemodynamics and neurohormones in isolated diastolic heart failure. (8640980)	Clarkson P.B.... Macdonald T.M.	1996	NPPB
21	Paracrine coronary endothelial modulation of diastolic left ventricular function in man: implications for diastolic heart failure. (8951574)	Paulus W.J.	1996	NPPA

Genes related to diastolic heart failure according to GeneCards:

(show all 18)

id	Symbol	Description	Score	GeneCards Section Context
1	MURC	muscle-related coiled-coil protein	11.0
2	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	11.0	Publications
3	LOXL3	lysyl oxidase-like 3	11.0
4	SHF	Src homology 2 domain containing F	11.0
5	CYBB	cytochrome b-245, beta polypeptide	11.0	Publications
6	PVALB	parvalbumin	11.0
7	NPPB	natriuretic peptide B	11.0	Publications
8	AGTR1	angiotensin II receptor, type 1	11.0	Publications
9	CST3	cystatin C	11.0	Publications
10	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
11	NPPA	natriuretic peptide A	11.0	Publications
12	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
13	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
14	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
15	BMP6	bone morphogenetic protein 6	11.0	Publications
16	MAPK8	mitogen-activated protein kinase 8	11.0	Publications
17	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
18	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications

Pathways related to diastolic heart failure according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	AGTR1
2	Glioma Invasiveness36	10.1	BMP6
3	Renin-angiotensin system20	9.7	ACE, AGT, AGTR1
4	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.3	NOS3, ACE, AGT, AGTR1
5	Development_Angiotensin signaling via PYK241	9.3	AGTR1, AGT, MAPK8
6	Angiogenesis3	9.1	MMP2, MMP9, NOS3
7	Activation of Matrix Metalloproteinases38	9.0	MMP9, MMP2, MMP1
8	Inhibition of Matrix Metalloproteinases36	8.9	MMP1, MMP2, MMP9
9	Bladder cancer20	8.9	MMP9, MMP2, MMP1
10	Cell adhesion_ECM remodeling41	8.8	MMP9, MMP2, MMP1
11	Cell adhesion ECM remodeling10	8.8	MMP9, MMP2, MMP1
12	Metalloproteases in connective tissue degradation10	8.7	CST3, MMP9, MMP2, MMP1
13	Development_EGFR signaling pathway41	8.6	MAPK8, MMP9, MMP2
14	Renin-Angiotensin Pathway36	8.5	AGTR1, AGT, ACE, MAPK8, BMP6
15	UPA-UPAR Pathway36	8.2	MMP1, MMP2, MMP9, MAPK8
16	Pancreatic Adenocarcinoma36	8.2	BMP6, MMP1, MMP2, MMP9

Compounds related to diastolic heart failure according to GeneDecks:

(show top 50)    (show all 198)

id	Compound	Score	Top Affiliating Genes
1	phenylephrine32 9 18 9	13.0	NPPB, AGT, AGTR1
2	pravastatin32 34 9 18 9	13.9	NPPB, NOS3
3	l-nmma32	9.7	NPPB, AGTR1, NPPA, AGT
4	trandolapril32 9 9	11.5	NPPA, NPPB, AGTR1, ACE
5	benazepril32 9 9	11.4	ACE, NPPA, AGTR1, AGT
6	candoxatril32 9 9	11.4	ACE, NPPA, NPPB
7	pge232	9.4	AGT, MMP1, NPPB
8	enalaprilat32	9.4	AGT, NPPA, ACE, NPPB
9	valsartan32 42 9 9	12.4	AGT, AGTR1, NPPB, ACE
10	aprotinin32 9 9	11.3	MMP2, MMP9, AGT, NPPB
11	metoprolol32 34 9 18 9	13.3	ACE, NPPA, NOS3, NPPB
12	telmisartan32 9 9	11.3	NPPB, AGTR1, AGT, ACE
13	celiprolol32	9.3	NOS3, ACE, NPPB
14	ramipril32 9 9	11.2	NPPA, CST3, ACE, AGTR1, NPPB
15	lisinopril32 9 18 9	12.2	NPPB, AGTR1, NPPA, ACE, AGT
16	chymostatin32	9.2	ACE, AGT, AGTR1, MMP9
17	digoxin32 42 34 9 18 9	14.2	CST3, NPPA, NPPB, AGTR1, ACE
18	amlodipine32 9 18 9	12.2	NOS3, ACE, AGTR1, NPPB, AGT
19	carvedilol32 34 9 9	12.1	AGTR1, NPPA, NOS3, NPPB, ACE
20	alacepril32	9.1	NPPA, ACE, NPPB
21	irbesartan32 9 9	11.1	ACE, MMP9, AGTR1, AGT
22	fosinopril32 9 9	11.0	AGTR1, NPPA, NPPB, MMP9, ACE
23	cgs-27023a32	9.0	MMP1, MMP2, MMP9
24	perindopril32 34 9 9	11.9	NPPB, NPPA, AGTR1, AGT, ACE, NOS3
25	captopril32 42 9 9	11.8	MMP2, AGT, CST3, NPPA, NPPB, ACE
26	8-isoprostane32	8.8	CYBB, MMP9, MMP2, NOS3, AGTR1, NPPB
27	enalapril32 9 9	10.7	ACE, AGT, AGTR1, NPPA, NPPB, BMP6
28	haloperidol32 34 9 9	11.6	AGTR1, MMP1, AGT, PVALB, NPPA, NPPB
29	nitric oxide32 9 18 9	11.6	ACE, CYBB, NPPB, AGT, NOS3, BMP6
30	n acetylcysteine32	8.4	MMP2, MMP1, MMP9, AGT, CST3
31	nifedipine32 9 9	10.4	AGT, NPPA, MMP9, ACE, AGTR1, BMP6
32	prostacyclin32	8.3	AGT, NPPB, NPPA, AGTR1, ACE, NOS3
33	ang ii32	8.3	NOS3, AGT, AGTR1, NPPA, MAPK8, ACE
34	rosiglitazone32 9 18 9	11.1	NOS3, MMP2, MMP1, MMP9, AGTR1, NPPB
35	procollagen32	8.1	MMP9, NPPB, BMP6, MMP1, MMP2
36	candesartan32 9 9	10.0	NPPB, AGTR1, AGT, ACE, NOS3, MMP2
37	losartan32 34 9 9	10.9	BMP6, MMP1, ACE, AGT, AGTR1, NPPA
38	aspirin32 34 18	9.7	MMP1, MMP2, BMP6, AGTR1, NPPB, ACE
39	atorvastatin32 34 9 18 9	11.7	MMP2, NPPB, AGT, NOS3, BMP6, MMP1
40	cyclosporin a32 42	8.4	AGT, NPPB, NPPA, AGTR1, BMP6, MMP1
41	vegf32	7.4	AGTR1, CST3, NPPB, NPPA, AGT, NOS3
42	epinephrine32 9 18 9	10.4	MMP2, BMP6, MMP1, NPPA, NPPB, MMP9
43	genistein32 9 18 9	10.2	AGTR1, MMP1, MMP2, MAPK8, NOS3, MMP9
44	pd 98,05932	7.1	MMP1, MMP2, MMP9, MAPK8, NOS3, AGT
45	norepinephrine32 9 18 9	10.0	MMP9, AGTR1, BMP6, MMP1, AGT, MMP2
46	h2o232	6.9	BMP6, MMP1, MMP2, MAPK8, CYBB, NOS3
47	dexamethasone32 42 34 9 9	10.9	AGTR1, NPPB, BMP6, AGT, CYBB, MMP1
48	sb 20358032 42	7.8	BMP6, MMP2, MMP1, MAPK8, AGT, AGTR1
49	creatinine32	6.7	MMP9, NPPA, NPPB, CST3, AGTR1, AGT
50	serine32	5.9	NOS3, CYBB, AGTR1, NPPB, BMP6, PVALB

Cellular components related to diastolic heart failure according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.3	NPPA, CST3, AGT, LOXL3, MMP9, MMP2
2	extracellular space	GO:005615	7.2	BMP6, NPPB, CST3, AGT, ACE, LOXL3

Biological processes related to diastolic heart failure according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of NAD(P)H oxidase activity	GO:033864	10.2	AGTR1, AGT
2	regulation of blood vessel size by renin-angiotensin	GO:002034	10.1	AGTR1, AGT
3	renin-angiotensin regulation of aldosterone production	GO:002018	10.1	AGTR1, AGT
4	regulation of renal sodium excretion	GO:035813	10.1	AGTR1, AGT
5	regulation of renal output by angiotensin	GO:002019	10.0	AGT, ACE
6	positive regulation of cholesterol esterification	GO:010873	10.0	AGT, AGTR1
7	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	9.9	AGTR1, ACE
8	cGMP biosynthetic process	GO:006182	9.9	NPPA, NPPB
9	low-density lipoprotein particle remodeling	GO:034374	9.9	AGTR1, AGT
10	positive regulation of cellular protein metabolic process	GO:032270	9.9	AGT, AGTR1
11	regulation of blood vessel size	GO:050880	9.8	NOS3, NPPA, NPPB
12	regulation of vasodilation	GO:042312	9.8	ACE, AGTR1, NPPB
13	receptor guanylyl cyclase signaling pathway	GO:007168	9.8	NPPA, NPPB
14	regulation of vasoconstriction	GO:019229	9.8	ACE, AGT, AGTR1
15	blood vessel remodeling	GO:001974	9.6	AGT, ACE, NOS3
16	positive regulation of renal sodium excretion	GO:035815	9.6	AGT, NPPB
17	cellular response to mechanical stimulus	GO:071260	9.5	ANKRD1, MAPK8, AGT
18	regulation of blood pressure	GO:008217	9.4	NPPB, NPPA, ACE, NOS3
19	kidney development	GO:001822	9.2	AGTR1, AGT, ACE, BMP6
20	positive regulation of apoptotic process	GO:043065	9.2	AGT, NOS3, ANKRD1, MMP9
21	collagen catabolic process	GO:030574	9.0	MMP1, MMP2, MMP9
22	extracellular matrix disassembly	GO:022617	9.0	MMP1, MMP2, MMP9
23	extracellular matrix organization	GO:030198	8.6	MMP1, MMP2, MMP9, AGT

Molecular functions related to diastolic heart failure according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	acetyltransferase activator activity	GO:010698	9.9	AGT, AGTR1
2	bradykinin receptor binding	GO:031711	9.6	ACE, AGTR1
3	peptide hormone receptor binding	GO:051428	9.6	NPPA, NPPB
4	hormone activity	GO:005179	9.5	AGT, NPPA, NPPB