MCID: DST006
MIFTS: 55

Diastolic Heart Failure malady

Cardiovascular diseases category
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Summaries for Diastolic Heart Failure

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Wikipedia:65 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

MalaCards based summary: Diastolic Heart Failure, also known as heart failure, diastolic, is related to pulmonary hypertension and hypertension. An important gene associated with Diastolic Heart Failure is ANKRD1 (ankyrin repeat domain 1 (cardiac muscle)), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The compounds trandolapril and benazepril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Diastolic Heart Failure

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Diastolic Heart Failure, Aliases & Descriptions:

Name: Diastolic Heart Failure 8 10
 
Heart Failure, Diastolic 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:9775
ICD9CM27 428.30, 428.3
SNOMED-CT57 418304008
MeSH34 D054144

Related Diseases for Diastolic Heart Failure

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Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary hypertension30.8NOS3, NPPA, NPPB, AGT
2hypertension30.8MMP9, ACE, CST3, NOS3, NPPA, NPPB
3congestive heart failure30.7AGTR1, AGT, NPPB, NPPA, ACE
4hypertensive heart disease30.7MMP1, ACE, NPPA, NPPB, AGTR1
5vascular disease30.7MAPK8, MMP2
6familial hypertrophic cardiomyopathy30.5TTN, MYBPC3
7insulin resistance30.0ACE, MAPK8, NOS3, AGT, AGTR1
8myocardial infarction29.8ACE, CST3, NOS3, NPPA, NPPB, AGT
9ischemia29.7TTN, MAPK8, CST3, NOS3, NPPB, AGT
10diabetes mellitus29.2MMP9, ACE, MAPK8, CST3, NOS3, NPPA
11atherosclerosis28.4AGTR1, AGT, NOS3, CST3, MAPK8, BMP6
12hypertension, diastolic10.6
13central sleep apnea10.6NPPB
14mitral valve disease10.5NPPA
15sick sinus syndrome10.5NPPA
16hepatorenal syndrome10.5NPPA
17mitral valve prolapse10.5AGTR1
18gitelman syndrome10.5AGT
19kidney disease10.5
20endotheliitis10.5
21oral submucous fibrosis10.5MMP1
22meningioma10.5CST3
23oligohydramnios10.5ACE
24renal tubular dysgenesis10.4AGT, AGTR1
25amyloidosis10.4
26myeloma10.4
27blindness10.4
28nephrosclerosis10.4ACE, AGTR1
29mitral valve insufficiency10.4NPPB, NPPA
30syndrome of inappropriate antidiuretic hormone10.4NPPB, NPPA
31mitral valve stenosis10.4NPPA, NPPB
32heart valve disease10.4NPPA, NPPB
33conn's syndrome10.4NPPA, AGTR1
34sudden cardiac death multi-gene panels10.3MYBPC3, ACE, NPPB
35cor pulmonale10.3NPPA, NPPB, AGTR1
36vesicoureteral reflux10.3AGT, AGTR1
37pure autonomic failure10.3ACE, NPPA
38multiple myeloma10.3
39hypertrophic cardiomyopathy10.3
40constrictive pericarditis10.3
41acute myocarditis10.3
42artery disease10.3
43myocarditis10.3
44pericarditis10.3
45erythrocytosis10.3ACE, AGTR1
46thoracic aortic aneurysm10.3MMP1, MMP2
47fibromatosis, gingival10.3MMP2, MMP1
48aortic valve stenosis10.3NPPA, NPPB, AGT
49renovascular hypertension10.3ACE, NPPA, AGTR1
50cerebrovascular disease10.3ACE, CST3, AGTR1

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to diastolic heart failure

Symptoms for Diastolic Heart Failure

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Drugs & Therapeutics for Diastolic Heart Failure

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Drug clinical trials:

Search ClinicalTrials for Diastolic Heart Failure

Search NIH Clinical Center for Diastolic Heart Failure

Genetic Tests for Diastolic Heart Failure

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Anatomical Context for Diastolic Heart Failure

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MalaCards organs/tissues related to Diastolic Heart Failure:

32
Heart, Lung, Brain, Kidney, Testes, Endothelial

Animal Models for Diastolic Heart Failure or affiliated genes

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MGI Mouse Phenotypes related to Diastolic Heart Failure:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6MYBPC3, ACE, MAPK8, AGT, NOS3
2MP:00020068.0MMP9, MMP2, MMP1, MAPK8, CST3, ACE
3MP:00053677.8MAPK8, AGT, NOS3, CYBB, MMP9, ACE
4MP:00053897.5NOS3, MAPK8, BMP6, ACE, AGT, MMP9
5MP:00036317.4AGT, CYBB, MMP9, MAPK8, MADD, CST3
6MP:00053977.3CYBB, MMP9, MMP2, ACE, MAPK8, NOS3
7MP:00053867.1CYBB, AGT, NOS3, MADD, MAPK8, ACE
8MP:00053876.6MMP9, MMP1, ACE, MAPK8, AGTR1, TTN
9MP:00107686.6TTN, AGT, NOS3, MADD, MAPK8, ACE
10MP:00053696.4CYBB, ANKRD1, AGT, NPPB, TTN, NPPA
11MP:00053786.0CYBB, AGTR1, AGT, NOS3, MAPK8, BMP6
12MP:00053856.0MAPK8, ACE, MMP2, MMP9, MYBPC3, NPPB
13MP:00053765.8MMP9, MMP2, ACE, CST3, NOS3, AGTR1

Publications for Diastolic Heart Failure

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Articles related to Diastolic Heart Failure:

(show top 50)    (show all 427)
idTitleAuthorsYear
1
Constrictive pericarditis--a curable diastolic heart failure. (25072910)
2014
2
Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. (25354950)
2014
3
Association and interaction analysis of metabolic syndrome and serum uric acid on diastolic heart failure. (23404264)
2013
4
Spironolactone made no difference to patients with mild diastolic heart failure. (23447350)
2013
5
Energy transfer from systole to diastole: a novel device-based approach for the treatment of diastolic heart failure. (22142202)
2011
6
Adaptive servoventilation in diastolic heart failure and Cheyne-Stokes respiration. (20032021)
2010
7
Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. (19850745)
2010
8
Usefulness of left atrial volume for the diagnosis of diastolic heart failure: an echocardiographic-catheterization study. (19297043)
2010
9
Office management of patients with diastolic heart failure. (19255076)
2009
10
Hypertension and diastolic heart failure. (19863866)
2009
11
Current perspectives on cardiac function in patients with diastolic heart failure. (19255354)
2009
12
Novel strategies for the detection of systolic and diastolic heart failure. (20436851)
2009
13
Effects of fixed-dose isosorbide dinitrate/hydralazine on diastolic function and exercise capacity in hypertension-induced diastolic heart failure. (19620510)
2009
14
An unusual case of hypertensive diastolic heart failure with bilateral subclavian artery stenosis. (19214295)
2009
15
Diabetes and prognosis: are systolic and diastolic heart failure different? (19033294)
2009
16
Hemodynamic characteristics of patients with diastolic heart failure and hypertension. (18971551)
2008
17
Optimal noninvasive assessment of diastolic heart failure in patients with atrial fibrillation: comparison of tissue doppler echocardiography, left atrium size, and brain natriuretic peptide. (17904810)
2008
18
Focale: study of systolic and diastolic heart failure in a French elderly population. (17399824)
2008
19
Renin-angiotensin system gene polymorphisms and diastolic heart failure. (19021695)
2008
20
The effects of maximal treadmill graded exercise testing on haemorheological, haemodynamic and flow cytometry platelet markers in patients with systolic or diastolic heart failure. (18257777)
2008
21
Digoxin and reduction of heart failure hospitalization in chronic systolic and diastolic heart failure. (19064024)
2008
22
Treating diastolic heart failure. (18625789)
2008
23
Elevation of the ratio of transmitral E velocity to early diastolic mitral annular velocity continues even after recovery from acute stage in patients with diastolic heart failure. (19027604)
2008
24
Left ventricular geometry and renal function in hypertensive patients with diastolic heart failure. (17261425)
2007
25
How to diagnose diastolic heart failure a consensus statement. (17890729)
2007
26
How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. (17428822)
2007
27
Ventriculovascular coupling in systolic and diastolic heart failure. (17543251)
2006
28
Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy. (16214409)
2006
29
Force- and relaxation-frequency relations in patients with diastolic heart failure. (17070168)
2006
30
Clinical advances in diastolic heart failure. (17167382)
2006
31
Diastolic heart failure in the elderly and the potential role of aldosterone antagonists. (16732689)
2006
32
Diastolic heart failure: perception of the syndrome and scope of the problem. (17084176)
2006
33
Treating diastolic heart failure with AGE crosslink breakers: thinking outside the heart failure box. (15812747)
2005
34
ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure. (15662228)
2005
35
Diagnostic criteria for diastolic heart failure. (16003646)
2005
36
Diastolic dysfunction and diastolic heart failure: mechanisms and epidemiology. (15865857)
2005
37
Ventriculovascular coupling in systolic and diastolic heart failure. (16332314)
2005
38
Heart rate variability and diastolic heart failure. (15009853)
2004
39
Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. (14715184)
2004
40
Management of diastolic heart failure in older adults: B-type natriuretic peptide was not mentioned. (15178632)
2004
41
Diastolic heart failure. (14630731)
2003
42
Angiotensin II type 1 and endothelin type A receptor antagonists modulate the extracellular matrix regulatory system differently in diastolic heart failure. (12569276)
2003
43
Prevention of diastolic heart failure by endothelin type A receptor antagonist through inhibition of ventricular structural remodeling in hypertensive heart. (11910313)
2002
44
Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction. (11889013)
2002
45
Defining diastolic heart failure. (11294819)
2001
46
Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? (11502702)
2001
47
Diastolic heart failure: identification and characterization. Is there a role for invasive methods? (10582454)
1999
48
Treating diastolic heart failure: the role of calcium antagonists. (10582472)
1999
49
Diastolic heart failure: identification and characterization. Doppler echocardiography: the "old" approach. (10582451)
1999
50
Mechanisms, diagnosis, and treatment of diastolic heart failure. (7611107)
1995

Variations for Diastolic Heart Failure

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Expression for genes affiliated with Diastolic Heart Failure

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Expression patterns in normal tissues for genes affiliated with Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for genes affiliated with Diastolic Heart Failure

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Pathways related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NPPB, NPPA
29.7MMP2, MMP1
39.7AGT, MAPK8
49.6MMP9, MMP1
5
Show member pathways
Angiogenesis37
9.5NOS3, MMP9
69.4MMP2, MMP9, CYBB
79.4NPPA, NOS3, CYBB
8
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.3ACE, MYBPC3, TTN
99.3MMP2, ACE, MMP9
10
Show member pathways
9.2MMP9, MMP2, MMP1
119.2MMP1, MMP9, MMP2
12
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.2MADD, MAPK8, MMP9
13
Show member pathways
9.1AGT, NOS3, ACE, AGTR1
149.1NPPA, MAPK8, AGT, NPPB
159.1NOS3, MMP2, MMP9
169.1MMP9, MMP2, NOS3
179.1MAPK8, MMP2, MMP9
189.1MMP9, MMP2, MAPK8
199.0CST3, MMP9, MMP2, ACE
20
Show member pathways
8.9MMP9, MMP2, MMP1, CST3
21
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.8AGTR1, MAPK8, MMP2, NOS3
228.7NOS3, MMP1, MMP2, MMP9
238.7MAPK8, MMP1, MMP2, MMP9
248.6MMP9, MMP2, NOS3, MAPK8
25
Show member pathways
8.5MMP9, MMP1, CYBB, MMP2, MAPK8
26
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.3NPPB, MMP2, NOS3, MMP9, MAPK8
27
Show member pathways
8.3ACE, AGTR1, AGT, MAPK8, BMP6
28
Show member pathways
7.4MAPK8, MMP1, NOS3, MMP9, BMP6, MMP2

Compounds for genes affiliated with Diastolic Heart Failure

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Compounds related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 252)
idCompoundScoreTop Affiliating Genes
1trandolapril44 1110.7NPPA, ACE, NPPB, AGTR1
2benazepril44 50 1111.6AGT, AGTR1, NPPA, ACE
3enalaprilat449.5AGT, NPPB, ACE, NPPA
4valsartan44 61 28 1112.5ACE, AGTR1, AGT, NPPB
5lisinopril44 50 24 1112.5AGTR1, AGT, NPPB, NPPA, ACE
6ramipril44 1110.4ACE, NPPB, NPPA, AGTR1, CST3
7atenolol44 50 28 24 1113.4AGTR1, AGT, MMP2, NPPB, ACE
8digoxin44 61 50 24 1113.3NPPA, AGTR1, CST3, NPPB, ACE
9chymostatin449.3ACE, MMP9, AGTR1, AGT
10fosinopril44 1110.3AGTR1, NPPA, ACE, MMP9, NPPB
11metoprolol44 50 28 24 1113.3NPPA, NOS3, NPPB, ACE
12carvedilol44 50 28 1112.2AGTR1, NPPB, NPPA, NOS3, ACE
13nitroglycerin44 1110.1ACE, NOS3, NPPA, NPPB, AGTR1
14telmisartan44 28 1111.1NPPB, AGT, AGTR1, ACE
15perindopril44 50 1111.0NPPB, AGT, AGTR1, NOS3, ACE, NPPA
16amlodipine44 50 24 1112.0AGT, NPPB, NPPA, NOS3, ACE, AGTR1
17phenylephrine44 28 24 1111.8NPPA, AGTR1, MMP2, AGT, NOS3, NPPB
18l-nmma448.8MMP9, NOS3, NPPA, NPPB, AGT, AGTR1
19aprotinin44 119.8AGT, NPPB, MMP9, MMP2, MMP1, CST3
20captopril44 61 50 28 1112.8MMP2, CST3, ACE, NPPA, NPPB, AGT
218-isoprostane448.8CYBB, NPPB, NOS3, MMP2, MMP9, AGTR1
22pravastatin44 50 28 24 1112.7MMP1, MMP2, ACE, NOS3, NPPB, AGTR1
23fluvastatin44 50 28 1111.7AGTR1, NOS3, MMP1, MMP9, ACE
24enalapril44 50 1110.7AGT, BMP6, ACE, AGTR1, NPPB, NPPA
25rosiglitazone28 44 50 24 1112.5NPPB, MMP9, MMP2, MMP1, NOS3, AGTR1
26candesartan44 50 28 1111.5MMP2, AGTR1, AGT, NPPB, NOS3, ACE
27ang ii448.5NPPB, NPPA, NOS3, MAPK8, ACE, AGTR1
28nifedipine44 28 50 1111.3AGTR1, MMP9, AGT, NPPA, BMP6, ACE
29losartan44 50 28 1111.3NPPB, AGTR1, AGT, NPPA, BMP6, MMP1
30n acetylcysteine448.2CST3, MMP9, MMP1, MAPK8, AGT, AGTR1
31procollagen448.2NPPB, BMP6, MMP1, MMP2, MMP9
32prostacyclin448.1AGTR1, AGT, ACE, BMP6, NOS3, NPPB
33arginine448.1MYBPC3, CST3, NOS3, AGT, AGTR1, CYBB
34aspirin44 50 28 2410.9MMP2, ACE, BMP6, NOS3, NPPB, AGTR1
35genistein44 28 61 2 24 1112.8AGT, MMP2, MMP9, NOS3, NPPB, AGTR1
36cyclosporin a44 28 619.8NPPA, CST3, NPPB, BMP6, MMP1, AGT
37epinephrine44 24 119.7MMP2, MMP9, NPPA, MMP1, BMP6, NPPB
38acetylcholine44 50 28 24 1111.7ACE, TTN, NOS3, NPPB, BMP6, AGT
39atorvastatin44 50 28 24 1111.5MMP9, MMP2, MMP1, ACE, BMP6, NOS3
40methotrexate50 44 119.5MMP2, MMP9, MMP1, NOS3, CST3, BMP6
41norepinephrine44 24 119.4ACE, MMP1, MMP2, MMP9, AGTR1, BMP6
42pge2447.4NPPB, MMP9, MMP2, MMP1, MAPK8, AGT
43dexamethasone44 50 28 1110.3MMP9, CYBB, BMP6, MMP1, MAPK8, CST3
44pd 98,059447.3MAPK8, MMP1, MMP2, MMP9, AGT, NOS3
45h2o2447.3MAPK8, CYBB, MMP1, NOS3, AGT, AGTR1
46sb 20358044 618.0MMP9, AGTR1, BMP6, MAPK8, NOS3, NPPB
47creatinine446.5TTN, MMP9, MMP2, MMP1, ACE, BMP6
48calcium44 50 24 119.5NOS3, AGTR1, AGT, CST3, NPPB, NPPA
49vegf446.2AGTR1, CYBB, MMP9, MMP2, MMP1, BMP6
50serine445.8AGTR1, AGT, NPPB, NOS3, CST3, BMP6

GO Terms for genes affiliated with Diastolic Heart Failure

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Cellular components related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I bandGO:0316749.6ANKRD1, TTN
2extracellular regionGO:0055767.0AGT, TTN, MMP9, MMP2, MMP1, ACE
3extracellular spaceGO:0056157.0MMP9, MMP2, ACE, BMP6, CST3, NPPA

Biological processes related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
3renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, AGT
4regulation of renal sodium excretionGO:03581310.3AGTR1, AGT
5positive regulation of cholesterol esterificationGO:01087310.2AGT, AGTR1
6regulation of renal output by angiotensinGO:00201910.2ACE, AGT
7regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.2ACE, AGTR1
8low-density lipoprotein particle remodelingGO:03437410.2AGTR1, AGT
9cGMP biosynthetic processGO:00618210.2NPPA, NPPB
10receptor guanylyl cyclase signaling pathwayGO:00716810.2NPPB, NPPA
11positive regulation of cellular protein metabolic processGO:03227010.2AGT, AGTR1
12positive regulation of renal sodium excretionGO:03581510.1NPPB, AGT
13regulation of vasodilationGO:04231210.1ACE, NPPB, AGTR1
14angiotensin maturationGO:00200310.0ACE, AGT
15regulation of vasoconstrictionGO:01922910.0ACE, AGT, AGTR1
16positive regulation of macrophage derived foam cell differentiationGO:01074410.0AGT, AGTR1
17cardiac muscle tissue morphogenesisGO:0550089.9ANKRD1, TTN
18sarcomere organizationGO:0452149.8ANKRD1, MYBPC3, TTN
19regulation of blood vessel sizeGO:0508809.8NPPB, NPPA, NOS3
20blood vessel remodelingGO:0019749.7AGT, NOS3, ACE
21negative regulation of cell growthGO:0303089.7AGT, NPPB, NPPA
22nitric oxide mediated signal transductionGO:0072639.6AGT, NOS3
23collagen catabolic processGO:0305749.5MMP1, MMP2, MMP9
24regulation of blood pressureGO:0082179.4ACE, NOS3, NPPA, NPPB
25extracellular matrix disassemblyGO:0226179.4MMP1, MMP2, MMP9
26extracellular matrix organizationGO:0301989.2AGT, MMP1, MMP2, MMP9
27kidney developmentGO:0018229.2AGTR1, AGT, BMP6, ACE
28positive regulation of protein secretionGO:0507149.1BMP6, ANKRD1
29cellular protein metabolic processGO:0442679.1AGT, ACE, MMP1, MMP2
30cellular response to mechanical stimulusGO:0712608.7AGT, NPPA, MAPK8, BMP6, ANKRD1

Molecular functions related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1titin bindingGO:03143210.0ANKRD1, MYBPC3
2bradykinin receptor bindingGO:0317119.9AGTR1, ACE
3hormone activityGO:0051799.5NPPA, NPPB, AGT
4metalloendopeptidase activityGO:0042228.9MMP9, MMP2, MMP1
5protein bindingGO:0055156.1MAPK8, ANKRD1, MADD, CST3, NOS3, AGT

Products for genes affiliated with Diastolic Heart Failure

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Sources for Diastolic Heart Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet