Aliases & Classifications for Diastolic Heart Failure

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Diastolic Heart Failure, Aliases & Descriptions:

Name: Diastolic Heart Failure 9 11
 
Heart Failure, Diastolic 60


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Disease Ontology9 DOID:9775
MeSH33 D054144
SNOMED-CT55 418304008
ICD9CM27 428.30, 428.3

Summaries for Diastolic Heart Failure

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Wikipedia:63 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

MalaCards based summary: Diastolic Heart Failure, also known as heart failure, diastolic, is related to atrial fibrillation and hypertrophic cardiomyopathy. An important gene associated with Diastolic Heart Failure is ANKRD1 (ankyrin repeat domain 1 (cardiac muscle)), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The compounds trandolapril and benazepril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are adipose tissue and tumorigenesis.

Related Diseases for Diastolic Heart Failure

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Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1atrial fibrillation30.8ACE, NPPA, NPPB, AGTR1
2hypertrophic cardiomyopathy30.7TTN, MYBPC3
3congestive heart failure30.7AGTR1, AGT, NPPB, NPPA, ACE
4pulmonary hypertension30.7BMP6, NPPA, NPPB
5hypertensive heart disease30.7MMP1, ACE, NPPA, NPPB, AGTR1
6kidney disease30.7MMP2, CST3, NOS3, AGT, AGTR1
7vascular disease30.6MAPK8, MMP2
8aneurysm30.5CST3, MMP2, MMP9
9coronary artery disease30.3ACE, CST3, NOS3, NPPB, AGT, AGTR1
10myocardial infarction29.8ACE, CST3, NOS3, NPPA, NPPB, AGT
11ischemia29.7TTN, MAPK8, CST3, NOS3, NPPB, AGT
12atherosclerosis28.4AGTR1, AGT, NOS3, CST3, MAPK8, BMP6
13hypertension, diastolic10.6
14central sleep apnea10.6NPPB
15mitral valve disease10.5NPPA
16sick sinus syndrome10.5NPPA
17hepatorenal syndrome10.5NPPA
18orthostatic intolerance10.5AGTR1
19gitelman syndrome10.5AGT
20endotheliitis10.5
21oral submucous fibrosis10.5MMP1
22meningioma, familial10.5CST3
23oligohydramnios10.5ACE
24renal tubular dysgenesis10.4AGT, AGTR1
25hemorrhage, intracerebral10.4CST3, NPPB
26amyloidosis10.4
27myeloma10.4
28blindness10.4
29nephrosclerosis10.4ACE, AGTR1
30mitral valve insufficiency10.4NPPB, NPPA
31syndrome of inappropriate antidiuretic hormone10.4NPPB, NPPA
32mitral valve stenosis10.4NPPA, NPPB
33heart valve disease10.4NPPA, NPPB
34conn's syndrome10.3NPPA, AGTR1
35sudden cardiac death multi-gene panels10.3MYBPC3, ACE, NPPB
36vesicoureteral reflux10.3AGT, AGTR1
37cor pulmonale10.3NPPA, NPPB, AGTR1
38multiple myeloma10.3
39constrictive pericarditis10.3
40acute myocarditis10.3
41artery disease10.3
42myocarditis10.3
43pericarditis10.3
44pure autonomic failure10.3ACE, NPPA
45thoracic aortic aneurysm10.3MMP1, MMP2
46fibromatosis, gingival10.3MMP2, MMP1
47aortic valve disease 210.3NPPA, NPPB, AGT
48renovascular hypertension10.3ACE, NPPA, AGTR1
49cerebrovascular disease10.3ACE, CST3, AGTR1
50idiopathic edema10.3NPPB, NPPA, ACE

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to diastolic heart failure

Symptoms for Diastolic Heart Failure

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Drugs & Therapeutics for Diastolic Heart Failure

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Drug clinical trials:

Search ClinicalTrials for Diastolic Heart Failure

Search NIH Clinical Center for Diastolic Heart Failure

Genetic Tests for Diastolic Heart Failure

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Anatomical Context for Diastolic Heart Failure

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MalaCards organs/tissues related to Diastolic Heart Failure:

31
Heart, Lung, Brain, Kidney, Testes, Endothelial

Animal Models for Diastolic Heart Failure or affiliated genes

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MGI Mouse Phenotypes related to Diastolic Heart Failure:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6MYBPC3, ACE, MAPK8, NOS3, AGT
2MP:00020068.0CYBB, MMP9, MMP2, MMP1, ACE, MAPK8
3MP:00053677.8CYBB, MMP9, ACE, MAPK8, NOS3, NPPA
4MP:00053897.5AGT, NOS3, MAPK8, BMP6, ACE, MMP9
5MP:00036317.4CYBB, MMP9, MMP2, MAPK8, MADD, CST3
6MP:00053977.3CYBB, MMP9, MMP2, ACE, MAPK8, NOS3
7MP:00053867.1CYBB, TTN, MYBPC3, MMP9, ACE, MAPK8
8MP:00053876.6MMP2, MMP9, TTN, CYBB, MMP1, ACE
9MP:00107686.6CYBB, TTN, MMP9, MMP2, ACE, MAPK8
10MP:00053696.4AGT, CYBB, TTN, MYBPC3, MMP9, MMP2
11MP:00053786.0CYBB, TTN, MYBPC3, MMP9, MMP2, ACE
12MP:00053856.0MMP2, MMP9, MYBPC3, TTN, CYBB, ACE
13MP:00053765.8MMP2, MMP9, MYBPC3, TTN, CYBB, MMP1

Publications for Diastolic Heart Failure

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Articles related to Diastolic Heart Failure:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
Constrictive pericarditis--a curable diastolic heart failure. (25072910)
2014
2
Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. (25354950)
2014
3
Association and interaction analysis of metabolic syndrome and serum uric acid on diastolic heart failure. (23404264)
2013
4
Spironolactone made no difference to patients with mild diastolic heart failure. (23447350)
2013
5
Energy transfer from systole to diastole: a novel device-based approach for the treatment of diastolic heart failure. (22142202)
2011
6
Adaptive servoventilation in diastolic heart failure and Cheyne-Stokes respiration. (20032021)
2010
7
Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. (19850745)
2010
8
Office management of patients with diastolic heart failure. (19255076)
2009
9
Hypertension and diastolic heart failure. (19863866)
2009
10
Current perspectives on cardiac function in patients with diastolic heart failure. (19255354)
2009
11
Novel strategies for the detection of systolic and diastolic heart failure. (20436851)
2009
12
Effects of fixed-dose isosorbide dinitrate/hydralazine on diastolic function and exercise capacity in hypertension-induced diastolic heart failure. (19620510)
2009
13
An unusual case of hypertensive diastolic heart failure with bilateral subclavian artery stenosis. (19214295)
2009
14
Diabetes and prognosis: are systolic and diastolic heart failure different? (19033294)
2009
15
Hemodynamic characteristics of patients with diastolic heart failure and hypertension. (18971551)
2008
16
Optimal noninvasive assessment of diastolic heart failure in patients with atrial fibrillation: comparison of tissue doppler echocardiography, left atrium size, and brain natriuretic peptide. (17904810)
2008
17
Focale: study of systolic and diastolic heart failure in a French elderly population. (17399824)
2008
18
Renin-angiotensin system gene polymorphisms and diastolic heart failure. (19021695)
2008
19
The effects of maximal treadmill graded exercise testing on haemorheological, haemodynamic and flow cytometry platelet markers in patients with systolic or diastolic heart failure. (18257777)
2008
20
Digoxin and reduction of heart failure hospitalization in chronic systolic and diastolic heart failure. (19064024)
2008
21
Treating diastolic heart failure. (18625789)
2008
22
Elevation of the ratio of transmitral E velocity to early diastolic mitral annular velocity continues even after recovery from acute stage in patients with diastolic heart failure. (19027604)
2008
23
Left ventricular geometry and renal function in hypertensive patients with diastolic heart failure. (17261425)
2007
24
How to diagnose diastolic heart failure a consensus statement. (17890729)
2007
25
How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. (17428822)
2007
26
Ventriculovascular coupling in systolic and diastolic heart failure. (17543251)
2006
27
Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy. (16214409)
2006
28
Force- and relaxation-frequency relations in patients with diastolic heart failure. (17070168)
2006
29
Clinical advances in diastolic heart failure. (17167382)
2006
30
Diastolic heart failure in the elderly and the potential role of aldosterone antagonists. (16732689)
2006
31
Diastolic heart failure: perception of the syndrome and scope of the problem. (17084176)
2006
32
Treating diastolic heart failure with AGE crosslink breakers: thinking outside the heart failure box. (15812747)
2005
33
ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure. (15662228)
2005
34
Diagnostic criteria for diastolic heart failure. (16003646)
2005
35
Diastolic dysfunction and diastolic heart failure: mechanisms and epidemiology. (15865857)
2005
36
Ventriculovascular coupling in systolic and diastolic heart failure. (16332314)
2005
37
Diastolic heart failure. (15659738)
2005
38
Heart rate variability and diastolic heart failure. (15009853)
2004
39
Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. (14715184)
2004
40
Management of diastolic heart failure in older adults: B-type natriuretic peptide was not mentioned. (15178632)
2004
41
Diastolic heart failure. (14630731)
2003
42
Angiotensin II type 1 and endothelin type A receptor antagonists modulate the extracellular matrix regulatory system differently in diastolic heart failure. (12569276)
2003
43
Prevention of diastolic heart failure by endothelin type A receptor antagonist through inhibition of ventricular structural remodeling in hypertensive heart. (11910313)
2002
44
Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction. (11889013)
2002
45
Defining diastolic heart failure. (11294819)
2001
46
Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? (11502702)
2001
47
Diastolic heart failure: identification and characterization. Is there a role for invasive methods? (10582454)
1999
48
Treating diastolic heart failure: the role of calcium antagonists. (10582472)
1999
49
Diastolic heart failure: identification and characterization. Doppler echocardiography: the "old" approach. (10582451)
1999
50
Mechanisms, diagnosis, and treatment of diastolic heart failure. (7611107)
1995

Variations for Diastolic Heart Failure

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Expression for genes affiliated with Diastolic Heart Failure

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Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for genes affiliated with Diastolic Heart Failure

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Pathways related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NPPB, NPPA
29.7MMP1, MMP2
39.7AGT, MAPK8
49.6MMP1, MMP9
5
Show member pathways
Angiogenesis36
9.5NOS3, MMP9
69.4CYBB, MMP9, MMP2
79.4CYBB, NOS3, NPPA
8
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.3TTN, MYBPC3, ACE
99.3MMP9, MMP2, ACE
109.2MMP9, MMP2, MMP1
11
Show member pathways
9.2MMP1, MMP2, MMP9
12
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.2MMP9, MAPK8, MADD
13
Show member pathways
9.1ACE, NOS3, AGT, AGTR1
149.1MAPK8, NPPA, NPPB, AGT
159.1MMP9, MMP2, NOS3
169.1NOS3, MMP2, MMP9
179.1MMP9, MMP2, MAPK8
189.1MAPK8, MMP2, MMP9
199.0CST3, ACE, MMP2, MMP9
20
Show member pathways
Metalloproteases in connective tissue degradation
8.9CST3, MMP1, MMP2, MMP9
21
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.8AGTR1, NOS3, MAPK8, MMP2
228.7NOS3, MMP1, MMP2, MMP9
238.7MAPK8, MMP1, MMP2, MMP9
248.6MMP9, MMP2, MAPK8, NOS3
25
Show member pathways
8.5CYBB, MMP9, MMP2, MMP1, MAPK8
26
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.3MMP9, MMP2, MAPK8, NOS3, NPPB
27
Show member pathways
8.3ACE, BMP6, MAPK8, AGT, AGTR1
28
Show member pathways
7.4MMP9, MMP2, MMP1, BMP6, MAPK8, NOS3

Compounds for genes affiliated with Diastolic Heart Failure

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Compounds related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

(show top 50)    (show all 252)
idCompoundScoreTop Affiliating Genes
1trandolapril43 1210.7NPPA, ACE, NPPB, AGTR1
2benazepril43 49 1211.6AGT, AGTR1, NPPA, ACE
3enalaprilat439.5AGT, NPPB, ACE, NPPA
4valsartan43 59 28 1212.5ACE, AGTR1, AGT, NPPB
5lisinopril43 49 24 1212.5AGTR1, AGT, NPPB, NPPA, ACE
6ramipril43 1210.4ACE, NPPB, NPPA, AGTR1, CST3
7atenolol43 49 28 24 1213.4AGTR1, AGT, MMP2, NPPB, ACE
8digoxin43 59 49 24 1213.3NPPA, AGTR1, CST3, NPPB, ACE
9chymostatin439.3ACE, MMP9, AGTR1, AGT
10fosinopril43 1210.3AGTR1, NPPA, ACE, MMP9, NPPB
11metoprolol43 49 28 24 1213.3NPPA, NOS3, NPPB, ACE
12carvedilol43 49 28 1212.2AGTR1, NPPB, NPPA, NOS3, ACE
13nitroglycerin43 1210.1ACE, NOS3, NPPA, NPPB, AGTR1
14telmisartan43 28 1211.1NPPB, AGT, AGTR1, ACE
15perindopril43 49 1211.0NPPB, AGT, AGTR1, NOS3, ACE, NPPA
16amlodipine43 49 24 1212.0AGT, NPPB, NPPA, NOS3, ACE, AGTR1
17phenylephrine43 28 24 1211.8NPPA, AGTR1, MMP2, AGT, NOS3, NPPB
18l-nmma438.8MMP9, NOS3, NPPA, NPPB, AGT, AGTR1
19aprotinin43 129.8AGT, NPPB, MMP9, MMP2, MMP1, CST3
20captopril43 59 49 28 1212.8MMP2, CST3, ACE, NPPA, NPPB, AGT
218-isoprostane438.8CYBB, NPPB, NOS3, MMP2, MMP9, AGTR1
22pravastatin43 49 28 24 1212.7MMP1, MMP2, ACE, NOS3, NPPB, AGTR1
23fluvastatin43 49 28 1211.7AGTR1, NOS3, MMP1, MMP9, ACE
24enalapril43 49 1210.7AGT, BMP6, ACE, AGTR1, NPPB, NPPA
25rosiglitazone28 43 49 24 1212.5NPPB, MMP9, MMP2, MMP1, NOS3, AGTR1
26candesartan43 49 28 1211.5MMP2, AGTR1, AGT, NPPB, NOS3, ACE
27ang ii438.5NPPB, NPPA, NOS3, MAPK8, ACE, AGTR1
28nifedipine43 28 49 1211.3AGTR1, MMP9, AGT, NPPA, BMP6, ACE
29losartan43 49 28 1211.3NPPB, AGTR1, AGT, NPPA, BMP6, MMP1
30n acetylcysteine438.2CST3, MMP9, MMP1, MAPK8, AGT, AGTR1
31procollagen438.2NPPB, BMP6, MMP1, MMP2, MMP9
32prostacyclin438.1AGTR1, AGT, ACE, BMP6, NOS3, NPPB
33arginine438.1MYBPC3, CST3, NOS3, AGT, AGTR1, CYBB
34aspirin43 49 28 2410.9MMP2, ACE, BMP6, NOS3, NPPB, AGTR1
35genistein43 28 59 2 24 1212.8AGT, MMP2, MMP9, NOS3, NPPB, AGTR1
36cyclosporin a43 28 599.8NPPA, CST3, NPPB, BMP6, MMP1, AGT
37epinephrine43 24 129.7MMP2, MMP9, NPPA, MMP1, BMP6, NPPB
38acetylcholine43 49 28 24 1211.7ACE, TTN, NOS3, NPPB, BMP6, AGT
39atorvastatin43 49 28 24 1211.5MMP9, MMP2, MMP1, ACE, BMP6, NOS3
40methotrexate49 43 129.5MMP2, MMP9, MMP1, NOS3, CST3, BMP6
41norepinephrine43 24 129.4ACE, MMP1, MMP2, MMP9, AGTR1, BMP6
42pge2437.4NPPB, MMP9, MMP2, MMP1, MAPK8, AGT
43dexamethasone43 49 28 1210.3MMP9, CYBB, BMP6, MMP1, MAPK8, CST3
44pd 98,059437.3MAPK8, MMP1, MMP2, MMP9, AGT, NOS3
45h2o2437.3MAPK8, CYBB, MMP1, NOS3, AGT, AGTR1
46sb 20358043 598.0MMP9, AGTR1, BMP6, MAPK8, NOS3, NPPB
47creatinine436.5TTN, MMP9, MMP2, MMP1, ACE, BMP6
48calcium43 49 24 129.5NOS3, AGTR1, AGT, CST3, NPPB, NPPA
49vegf436.2AGTR1, CYBB, MMP9, MMP2, MMP1, BMP6
50serine435.8AGTR1, AGT, NPPB, NOS3, CST3, BMP6

GO Terms for genes affiliated with Diastolic Heart Failure

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Cellular components related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1I bandGO:00316749.6ANKRD1, TTN
2extracellular regionGO:00055767.0AGT, TTN, MMP9, MMP2, MMP1, ACE
3extracellular spaceGO:00056157.0MMP9, MMP2, ACE, BMP6, CST3, NPPA

Biological processes related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:003386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:000203410.3AGT, AGTR1
3renin-angiotensin regulation of aldosterone productionGO:000201810.3AGTR1, AGT
4regulation of renal sodium excretionGO:003581310.3AGTR1, AGT
5positive regulation of cholesterol esterificationGO:001087310.2AGT, AGTR1
6regulation of renal output by angiotensinGO:000201910.2ACE, AGT
7regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.2ACE, AGTR1
8low-density lipoprotein particle remodelingGO:003437410.2AGTR1, AGT
9cGMP biosynthetic processGO:000618210.2NPPA, NPPB
10receptor guanylyl cyclase signaling pathwayGO:000716810.2NPPB, NPPA
11positive regulation of cellular protein metabolic processGO:003227010.2AGT, AGTR1
12positive regulation of renal sodium excretionGO:003581510.1NPPB, AGT
13regulation of vasodilationGO:004231210.1ACE, NPPB, AGTR1
14angiotensin maturationGO:000200310.0ACE, AGT
15regulation of vasoconstrictionGO:001922910.0ACE, AGT, AGTR1
16positive regulation of macrophage derived foam cell differentiationGO:001074410.0AGT, AGTR1
17cardiac muscle tissue morphogenesisGO:00550089.9ANKRD1, TTN
18sarcomere organizationGO:00452149.8ANKRD1, MYBPC3, TTN
19regulation of blood vessel sizeGO:00508809.8NPPB, NPPA, NOS3
20blood vessel remodelingGO:00019749.7AGT, NOS3, ACE
21negative regulation of cell growthGO:00303089.7AGT, NPPB, NPPA
22nitric oxide mediated signal transductionGO:00072639.6AGT, NOS3
23collagen catabolic processGO:00305749.5MMP1, MMP2, MMP9
24regulation of blood pressureGO:00082179.4ACE, NOS3, NPPA, NPPB
25extracellular matrix disassemblyGO:00226179.4MMP1, MMP2, MMP9
26extracellular matrix organizationGO:00301989.2AGT, MMP1, MMP2, MMP9
27kidney developmentGO:00018229.2AGTR1, AGT, BMP6, ACE
28positive regulation of protein secretionGO:00507149.1BMP6, ANKRD1
29cellular protein metabolic processGO:00442679.1AGT, ACE, MMP1, MMP2
30cellular response to mechanical stimulusGO:00712608.7AGT, NPPA, MAPK8, BMP6, ANKRD1

Molecular functions related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1titin bindingGO:003143210.0ANKRD1, MYBPC3
2bradykinin receptor bindingGO:00317119.9AGTR1, ACE
3hormone activityGO:00051799.5NPPA, NPPB, AGT
4metalloendopeptidase activityGO:00042228.9MMP1, MMP2, MMP9
5protein bindingGO:00055156.1AGTR1, CYBB, TTN, MMP9, MMP2, ANKRD1

Products for genes affiliated with Diastolic Heart Failure

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Sources for Diastolic Heart Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet