MCID: DST006
MIFTS: 47

Diastolic Heart Failure

Categories: Cardiovascular diseases

Aliases & Classifications for Diastolic Heart Failure

MalaCards integrated aliases for Diastolic Heart Failure:

Name: Diastolic Heart Failure 12 14
Heart Failure, Diastolic 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9775
ICD10 32 I50.30
ICD9CM 34 428.3 428.30
MeSH 41 D054144
SNOMED-CT 64 418304008
UMLS 69 C1135196

Summaries for Diastolic Heart Failure

MalaCards based summary : Diastolic Heart Failure, also known as heart failure, diastolic, is related to kidney disease and congestive heart failure. An important gene associated with Diastolic Heart Failure is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Apelin signaling pathway. The drugs Spironolactone and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

Related Diseases for Diastolic Heart Failure

Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 kidney disease 30.1 ACE AGTR1 NPPB
2 congestive heart failure 30.1 ACE AGTR1 NPPB
3 systolic heart failure 30.0 ACE NPPB
4 chronic kidney failure 29.9 ACE AGT AGTR1 NPPB
5 renal hypertension 29.8 ACE AGTR1 NPPB
6 atrial fibrillation 29.7 ACE AGT AGTR1 NPPB
7 hypertrophic cardiomyopathy 29.7 ACE MYBPC3 NPPB
8 atrial standstill 1 29.6 ACE MYBPC3 NPPB
9 pulmonary hypertension 29.5 ACE NOS3 NPPB
10 autosomal dominant polycystic kidney disease 29.3 ACE AGT NOS3
11 pulmonary edema 29.2 ACE NOS3 NPPB
12 sleep apnea 29.2 ACE NOS3 NPPB
13 coronary artery anomaly 29.1 ACE AGTR1 NOS3 NPPB
14 hypertensive heart disease 29.1 ACE AGT AGTR1 MMP2 NPPB
15 pre-eclampsia 29.0 AGT AGTR1 NOS3
16 arteries, anomalies of 28.7 ACE AGT AGTR1 NOS3 NPPB
17 heart disease 28.2 ACE AGTR1 ANKRD1 MYBPC3 NOS3 NPPB
18 myocardial infarction 27.8 ACE AGT AGTR1 MMP2 NOS3 NPPB
19 pediatric hypertension 10.4 ACE AGT
20 hypertensive nephropathy 10.4 ACE AGTR1
21 anterolateral myocardial infarction 10.3 ACE NPPB
22 meningococcal infection 10.3 AGT AGTR1
23 syndrome of inappropriate antidiuretic hormone 10.3 ACE NPPB
24 aortic valve insufficiency 10.3 ACE NPPB
25 idiopathic edema 10.3 ACE NPPB
26 mitral valve insufficiency 10.3 ACE NPPB
27 familial hypertension 10.2 AGT AGTR1
28 hypertension, diastolic 10.2
29 posterior urethral valves 10.2 ACE AGT AGTR1
30 ureteral disease 10.2 ACE CTGF
31 anuria 10.2 ACE AGT AGTR1
32 malignant hypertension 10.2 ACE AGT AGTR1
33 heart conduction disease 10.2 ACE NPPB
34 interstitial nephritis 10.2 ACE AGT
35 fibromuscular dysplasia 10.1 ACE AGT AGTR1
36 oligohydramnios 10.1 ACE AGT AGTR1
37 renal tubular dysgenesis 10.1 ACE AGT AGTR1
38 aging 10.1
39 renal dysplasia 10.1 ACE AGT AGTR1
40 end stage renal failure 10.1 ACE AGT AGTR1
41 otosclerosis 10.1 ACE AGT AGTR1
42 aortic valve disease 2 10.1 ACE AGT NPPB
43 fibrosis of extraocular muscles, congenital, 1 10.1
44 endotheliitis 10.1
45 nephrosclerosis 10.0 ACE AGTR1 CTGF
46 vasculogenic impotence 10.0 ACE NOS3
47 familial isolated dilated cardiomyopathy 10.0 ANKRD1 MYBPC3
48 blood group, i system 10.0
49 diabetes mellitus 10.0
50 constrictive pericarditis 10.0

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to Diastolic Heart Failure

Symptoms & Phenotypes for Diastolic Heart Failure

MGI Mouse Phenotypes related to Diastolic Heart Failure:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 CTGF MMP2 MYBPC3 NOS3 ACE AGT
2 growth/size/body region MP:0005378 9.7 ANKRD1 CTGF MMP2 NOS3 ACE AGT
3 homeostasis/metabolism MP:0005376 9.56 CTGF MMP2 MYBPC3 NOS3 ACE AGT
4 muscle MP:0005369 9.02 MMP2 MYBPC3 NOS3 AGT ANKRD1

Drugs & Therapeutics for Diastolic Heart Failure

Drugs for Diastolic Heart Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
2
Valsartan Approved, Investigational Phase 4,Phase 3 137862-53-4 60846
3
Eplerenone Approved Phase 4,Phase 2,Phase 3 107724-20-9 443872 150310
4
Angiotensin II Approved, Investigational Phase 4,Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
6
Adenosine Approved, Investigational Phase 4 58-61-7 60961
7
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
11
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
12
Norethindrone Approved Phase 4 68-22-4 6230
13
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
14 Atorvastatin Calcium Phase 4 134523-03-8
15 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Vasodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Hormones Phase 4,Phase 3,Phase 2,Phase 1
18 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
19 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
20 Anticholesteremic Agents Phase 4
21 Hypolipidemic Agents Phase 4
22 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2
23 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
24 Antimetabolites Phase 4
25 Lipid Regulating Agents Phase 4
26 Calcium, Dietary Phase 4,Phase 2
27 Sildenafil Citrate Phase 4,Phase 3,Phase 2 171599-83-0
28 diuretics Phase 4,Phase 3,Phase 2
29 Mineralocorticoid Receptor Antagonists Phase 4,Phase 3,Phase 2
30 Mineralocorticoids Phase 4,Phase 3,Phase 2
31 Adrenergic beta-Antagonists Phase 4
32 Natriuretic Peptide, Brain Phase 4,Phase 1,Phase 2
33 Hormone Antagonists Phase 4,Phase 3,Phase 2
34 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3
35 Angiotensin Receptor Antagonists Phase 4,Phase 3
36 Angiotensinogen Phase 4,Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
38 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
39 Antihypertensive Agents Phase 4,Phase 3,Phase 2
40 Protective Agents Phase 4,Phase 1,Not Applicable
41 Adrenergic Agents Phase 4,Phase 2
42 Adrenergic Agonists Phase 4,Phase 2
43 Adrenergic beta-Agonists Phase 4
44 Neurotransmitter Agents Phase 4,Phase 2
45 Sodium Potassium Chloride Symporter Inhibitors Phase 4
46 Dopamine Agents Phase 4
47 Autonomic Agents Phase 4,Phase 2
48 glucagon Phase 4
49 Estradiol valerate Phase 4 979-32-8
50 Glucagon-Like Peptide 1 Phase 4

Interventional clinical trials:

(show top 50) (show all 119)

# Name Status NCT ID Phase Drugs
1 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Unknown status NCT01503671 Phase 4 Atorvastatin
2 Novel Treatment for Diastolic Heart Failure in Women Completed NCT00206232 Phase 4 Spironolactone
3 Aldosterone Antagonism in Diastolic Heart Failure Completed NCT00108251 Phase 4 Eplerenone;Placebo
4 A Trial of Fimasartan for Early Diastolic Heart Failure Completed NCT01691118 Phase 4 Fimasartan;Antihypertensive treatment
5 Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart Completed NCT01944384 Phase 4 aldactone
6 Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure Completed NCT00171106 Phase 4 valsartan
7 SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Completed NCT01046838 Phase 4 Sildenafil;Placebo
8 Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure Recruiting NCT02053246 Phase 4 Nebivolol
9 Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF Recruiting NCT02589977 Phase 4 regadenoson
10 Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction Active, not recruiting NCT01901809 Phase 4 Furosemide;Dopamine
11 Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure Terminated NCT00293150 Phase 4 Eplerenone
12 Use of Nesiritide in the Management of Acute Diastolic Heart Failure Terminated NCT00083772 Phase 4 Nesiritide
13 Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan Terminated NCT00840463 Phase 4 Ambrisentan
14 Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure Terminated NCT00799435 Phase 4 Exenatide
15 Estrogen Diastolic Heart Failure Terminated NCT02693002 Phase 4 Estradiol/Norethindrone acetate;Placebo
16 Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction Unknown status NCT01583881 Phase 2, Phase 3
17 A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction [ULTIMATE-HFpEF] Unknown status NCT01599117 Phase 3 Placebo;Udenafil (Zydena)
18 Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study) Completed NCT00763867 Phase 3 Placebo;Sildenafil
19 Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure Completed NCT01156636 Phase 2, Phase 3 Sildenafil;Placebo
20 Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure Completed NCT01411735 Phase 3 Enalapril;placebo
21 PIE II: Pharmacological Intervention in the Elderly II Completed NCT00123955 Phase 3 Spironolactone;Placebo
22 Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary Hypertension Completed NCT00820352 Phase 3 bosentan;placebo
23 Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function Completed NCT00094302 Phase 3 Spironolactone;Placebo
24 Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH Completed NCT01726049 Phase 3 Sildenafil;Placebo
25 Novel Cardiac Rehabilitation in Patients Heart Failure and Preserved Ejection Fraction Recruiting NCT02762825 Phase 3
26 Optimized Management of Comorbidity in Heart Failure With Preserved Ejection Fraction in the Elderly (>60 Years) Recruiting NCT02425371 Phase 3
27 Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction Active, not recruiting NCT01920711 Phase 3 LCZ696;Valsartan
28 Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline Chemotherapy for Breast Cancer Terminated NCT01708798 Phase 2, Phase 3 Eplerenone;Placebo
29 Study of Nesiritide in Diastolic Heart Failure. Completed NCT00309868 Phase 1, Phase 2 neseritide
30 A Study of the Effectiveness of Sitaxsentan Sodium in Patients With Diastolic Heart Failure Completed NCT00303498 Phase 2 Sitaxsentan sodium;Placebo
31 The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure Completed NCT00043836 Phase 2 ALT-711
32 Ranolazine in Diastolic Heart Failure Completed NCT01163734 Phase 2 Ranolazine
33 Perhexiline Therapy in Heart Failure With Preserved Ejection Fraction Syndrome Completed NCT00839228 Phase 2 Perhexiline;Placebo
34 Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF Completed NCT02256345 Phase 2 KNO3;KCl
35 Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction Completed NCT00387621 Phase 1, Phase 2 Nesiritide;Placebo;Saline
36 Interleukin-1 Blockade in HF With Preserved EF Completed NCT02173548 Phase 2 Anakinra;Placebo
37 Radiofrequency-based Speckle Tracking Echocardiography to Evaluate Diastolic Function Completed NCT01182805 Phase 1, Phase 2
38 Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFPEF Patients Treated With Allogeneic CDCs Recruiting NCT02941705 Phase 2
39 CoQ10 and D-ribose in Patients With Diastolic Heart Failure Not yet recruiting NCT03133793 Phase 2 CoQ10;D-Ribose Oral Powder
40 Beginning a Randomized Evaluation of the AGE Breaker Alagebrium in Diastolic Heart Failure (BREAK-DHF-I) Terminated NCT00662116 Phase 2 alagebrium;placebo
41 A Randomized Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Effects of Alagebrium on Exercise in Subjects With Diastolic Heart Failure Terminated NCT01913301 Phase 2 Alagebrium
42 The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure Terminated NCT01887353 Phase 2 Ranolazine;Placebo
43 A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction Terminated NCT01172756 Phase 2 Riociguat (BAY63-2521);Riociguat (BAY63-2521);Riociguat (BAY63-2521);Placebo
44 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn NCT00757055 Phase 2 Ivabradine;Placebo
45 Clonidine and Left Ventricular Dysfunction Withdrawn NCT00213902 Phase 2
46 BNP Testing in Patients With SOB on Presentation to ED Unknown status NCT00163709 Phase 1
47 Physiological Effects of Grape Seed Extract in Diastolic Heart Failure Completed NCT01185067 Phase 1 grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
48 Diastolic Heart Failure Management by Nifedipine Unknown status NCT01157481 Conventional therapy plus nifedipine;Conventional therapy
49 Effects of the Dietary Approaches to Stop Hypertension(DASH) Sodium-restricted Diet in Diastolic Heart Failure Unknown status NCT00939640
50 LEft Atrial Pacing in Diastolic Heart Failure Unknown status NCT01618981

Search NIH Clinical Center for Diastolic Heart Failure

Cochrane evidence based reviews: heart failure, diastolic

Genetic Tests for Diastolic Heart Failure

Anatomical Context for Diastolic Heart Failure

MalaCards organs/tissues related to Diastolic Heart Failure:

38
Heart, Lung, Testes, Brain, Endothelial, Kidney

Publications for Diastolic Heart Failure

Articles related to Diastolic Heart Failure:

(show top 50) (show all 458)
# Title Authors Year
1
Stachydrine ameliorates pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis. ( 28979698 )
2017
2
Shared biomarkers between female diastolic heart failure and pre-eclampsia: a systematic review and meta-analysis. ( 28451444 )
2017
3
Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup. ( 29354484 )
2017
4
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. ( 28818409 )
2017
5
Diastolic heart failure associated with hemangiosarcoma infiltrating left ventricular walls in a dog. ( 29089652 )
2017
6
Etiologies, Trends, and Predictors of 30-Day Readmissions in Patients With Diastolic Heart Failure. ( 28648393 )
2017
7
Exercise training in Diastolic Heart Failure (Ex-DHF): rationale and design of a multicentre, prospective, randomized, controlled, parallel group trial. ( 28516519 )
2017
8
The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction. A Doppler-Echocardiographic study. ( 29142810 )
2017
9
Complexity of pathomechanisms leading to diastolic heart failure in diabetes mellitus - potential field for therapeutic interventions? ( 28934928 )
2017
10
Age-dependent diastolic heart failure in an in vivo Drosophila model. ( 28328397 )
2017
11
Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2). ( 28475816 )
2017
12
Diastolic Heart Failure Predicted by Left Atrial Expansion Index in Patients with Severe Diastolic Dysfunction. ( 27622475 )
2016
13
Deliberations on Diastolic Heart Failure. ( 28029360 )
2016
14
The Stiff Left Atrium Is to Atrial Fibrillation as the Stiff Left Ventricle Is to Diastolic Heart Failure. ( 26966289 )
2016
15
Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial. ( 27072860 )
2016
16
Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case-control study. ( 26861937 )
2016
17
Diastolic heart failure: diagnosis and therapy. ( 26658178 )
2016
18
Clinical effects of combined treatment by optimal dose of furosemide and spironolactone on diastolic heart failure in elderly patients. ( 26998008 )
2016
19
Increased Prevalence of Diastolic Heart Failure in Patients with Rheumatoid Arthritis Correlates with Active Disease, but Not with Treatment Type. ( 26373561 )
2015
20
Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox. ( 25524917 )
2015
21
Constrictive pericarditis-a curable diastolic heart failure. ( 26440983 )
2015
22
Complete heart block with diastolic heart failure and pulmonary edema secondary to enlarging previously diagnosed thrombosed aneurysm of sinus of valsalva in a patient with history of autosomal dominant polycystic kidney disease. ( 25861484 )
2015
23
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. ( 26142467 )
2015
24
Successful resection of a huge metastatic liposarcoma in the pericardium resulting in improvement of diastolic heart failure: a case report. ( 26366370 )
2015
25
The association and interaction analysis of hypertension and diabetes mellitus on diastolic heart failure in a high-risk population. ( 26885071 )
2015
26
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice. ( 26461521 )
2015
27
Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). ( 25742762 )
2015
28
Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models. ( 24464932 )
2014
29
Impact of the renin-angiotensin system and inflammatory gene polymorphisms on diastolic heart failure. ( 24530241 )
2014
30
Socioeconomic factors and mortality in diastolic heart failure. ( 24467732 )
2014
31
Case 6/2014--A case of a 61-year-old woman with diastolic heart failure. ( 25590936 )
2014
32
Utility of lower limb positive pressure test for diagnosis of diastolic heart failure: a case report. ( 25264062 )
2014
33
Constrictive pericarditis--a curable diastolic heart failure. ( 25072910 )
2014
34
Association and predictive value analysis for metabolic syndrome on systolic and diastolic heart failure in high-risk patients. ( 25249273 )
2014
35
Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1): A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study. ( 24991733 )
2014
36
Heart failure with normal ejection fraction, heart failure with preserved ejection fraction, diastolic heart failure, or huff-puff: time for a new taxonomy for hypertensive-metabolic heart failure. ( 25151212 )
2014
37
CrossTalk opposing view: the late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488067 )
2014
38
Digoxin and 30-day All-cause Hospital Admission in Older Patients with Chronic Diastolic Heart Failure. ( 24067296 )
2014
39
CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488066 )
2014
40
Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. ( 25354950 )
2014
41
New diagnostic and therapeutic possibilities for diastolic heart failure. ( 24494212 )
2014
42
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. ( 24759122 )
2014
43
Myocardial energetics and ubiquinol in diastolic heart failure. ( 25263245 )
2014
44
Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure. ( 25267798 )
2014
45
Genetics of systolic and diastolic heart failure. ( 25380161 )
2014
46
Tissue Doppler-derived E/e' ratio as a parameter for assessing diastolic heart failure and as a predictor of mortality in patients with chronic kidney disease. ( 23345995 )
2013
47
Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF). ( 22983988 )
2013
48
Renin-angiotensin inhibition in diastolic heart failure and chronic kidney disease. ( 23331442 )
2013
49
RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study. ( 24621836 )
2013
50
Comparison between ivabradine and low-dose digoxin in the therapy of diastolic heart failure with preserved left ventricular systolic function. ( 24765517 )
2013

Variations for Diastolic Heart Failure

Expression for Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for Diastolic Heart Failure

GO Terms for Diastolic Heart Failure

Cellular components related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ACE AGT CTGF MMP2 NPPB
2 sarcomere GO:0030017 8.62 MMP2 MYBPC3

Biological processes related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.81 CTGF MMP2 NOS3
2 kidney development GO:0001822 9.72 ACE AGT AGTR1
3 regulation of lipid metabolic process GO:0019216 9.7 AGT ANKRD1 CTGF
4 regulation of cell growth GO:0001558 9.69 AGT AGTR1 CTGF
5 sarcomere organization GO:0045214 9.64 ANKRD1 MYBPC3
6 positive regulation of protein tyrosine kinase activity GO:0061098 9.63 ACE AGT
7 positive regulation of reactive oxygen species metabolic process GO:2000379 9.62 AGT AGTR1
8 positive regulation of blood vessel diameter GO:0097755 9.62 AGT NOS3
9 vasodilation GO:0042311 9.61 AGT NOS3
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.61 AGT MMP2
11 nitric oxide mediated signal transduction GO:0007263 9.6 AGT NOS3
12 positive regulation of cellular protein metabolic process GO:0032270 9.59 AGT AGTR1
13 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.58 AGT AGTR1
14 low-density lipoprotein particle remodeling GO:0034374 9.58 AGT AGTR1
15 positive regulation of renal sodium excretion GO:0035815 9.57 AGT NPPB
16 angiotensin maturation GO:0002003 9.56 ACE AGT
17 positive regulation of cholesterol esterification GO:0010873 9.54 AGT AGTR1
18 blood vessel remodeling GO:0001974 9.54 ACE AGT NOS3
19 regulation of vasoconstriction GO:0019229 9.5 ACE AGT AGTR1
20 positive regulation of NAD(P)H oxidase activity GO:0033864 9.49 AGT AGTR1
21 renin-angiotensin regulation of aldosterone production GO:0002018 9.48 AGT AGTR1
22 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.46 AGT AGTR1
23 regulation of renal sodium excretion GO:0035813 9.43 AGT AGTR1
24 regulation of blood vessel size GO:0050880 9.43 AGT NOS3 NPPB
25 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
26 regulation of blood vessel diameter GO:0097746 9.33 ACE AGTR1 NPPB
27 regulation of blood pressure GO:0008217 9.26 ACE AGT NOS3 NPPB
28 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.8 ACE AGT AGTR1

Molecular functions related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 titin binding GO:0031432 8.96 ANKRD1 MYBPC3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Diastolic Heart Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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