MCID: DST006
MIFTS: 52

Diastolic Heart Failure malady

Summaries for Diastolic Heart Failure

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

MalaCards: Diastolic Heart Failure, also known as heart failure, diastolic, is related to hypertension and congestive heart failure. An important gene associated with Diastolic Heart Failure is ANKRD1 (ankyrin repeat domain 1 (cardiac muscle)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The compounds captopril and rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Diastolic Heart Failure

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

diastolic heart failure 8 10
heart failure, diastolic 60


External Ids:

Disease Ontology8 DOID:9775
MeSH34 D054144
SNOMED-CT56 418304008
ICD9CM27 428.30, 428.3

Related Diseases for Diastolic Heart Failure

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17GeneCards, 18GeneDecks
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Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3CST3, NPPB, NPPA, AGTR1, AGT, MMP9
2congestive heart failure30.6NPPB, NPPA, AGTR1, AGT, ACE
3chronic kidney failure30.6CST3, NPPB, NPPA, AGTR1, AGT, NOS3
4amyloidosis30.5NPPB, CST3
5myeloma30.5MAPK8, CST3
6hypertensive heart disease30.5NPPB, NPPA, AGTR1, MMP1, ACE
7hypertrophic cardiomyopathy30.4MYBPC3
8myocarditis30.4NPPB
9coronary artery disease30.4CST3, ACE, NOS3, MMP9, CYBB, AGT
10familial hypertrophic cardiomyopathy30.2MYBPC3
11myocardial infarction30.1CST3, NPPB, NPPA, AGTR1, AGT, NOS3
12ischemia30.1PVALB, CST3, NPPB, AGT, MAPK8, NOS3
13vascular disease30.1CST3, BMP6, AGTR1, AGT, CYBB, MMP9
14diabetes mellitus30.1CST3, NPPB, NPPA, AGTR1, AGT, MAPK8
15atherosclerosis30.1CST3, BMP6, AGTR1, AGT, MAPK8, CYBB
16systolic heart failure11.0
17kidney disease10.4
18renal hypertension10.4
19acute myocarditis10.3
20multiple myeloma10.3
21peripheral vascular disease10.1
22cardiac tamponade10.1
23mixed connective tissue disease10.1
24cerebritis10.1
25systemic lupus erythematosus10.1
26heart lymphoma10.1
27peripartum cardiomyopathy10.1
28constrictive pericarditis10.1
29connective tissue disease10.1
30lupus erythematosus10.1
31pericarditis10.1
32respiratory failure10.1
33restrictive cardiomyopathy10.1
34sleep disorder10.1
35mitral valve prolapse10.0AGTR1
36central sleep apnea10.0NPPB
37pulmonary embolism10.0NPPB
38nephritis10.0ACE
39mitral valve disease10.0NPPA
40oligohydramnios10.0ACE
41anuria10.0ACE
42ureteral obstruction10.0AGTR1
43gitelman syndrome10.0AGT
44glaucoma10.0MMP1
45sick sinus syndrome10.0NPPA
46hepatorenal syndrome10.0NPPA
47hepatopulmonary syndrome10.0NOS3
48chagas disease10.0NPPB
49sickle cell disease10.0NOS3
50synovitis10.0MMP1

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to diastolic heart failure

Clinical Features for Diastolic Heart Failure

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Drugs & Therapeutics for Diastolic Heart Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Diastolic Heart Failure

Drug clinical trials:

Search ClinicalTrials for Diastolic Heart Failure

Search NIH Clinical Center for Diastolic Heart Failure

Search CenterWatch for Diastolic Heart Failure

Genetic Tests for Diastolic Heart Failure

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Anatomical Context for Diastolic Heart Failure

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32MalaCards
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MalaCards organs/tissues related to Diastolic Heart Failure:

32
Heart, Lung, Brain, Kidney, Endothelial, Testes

Animal Models for Diastolic Heart Failure or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diastolic Heart Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.6AGTR1, AGT, CYBB, ACE
2MP:00020068.7CST3, MAPK8, CYBB, MMP9
3MP:00053768.5CST3, NPPA, AGTR1, AGT, MYBPC3, CYBB
4MP:00053857.8AGTR1, NPPA, NPPB, CST3, AGT, MAPK8
5MP:00053867.5AGT, MADD, MAPK8, MYBPC3, CYBB, MMP9
6MP:00053696.9NOS3, PVALB, CST3, NPPB, NPPA, AGT
7MP:00053786.7BMP6, AGTR1, AGT, MAPK8, MYBPC3, CYBB

Publications for Diastolic Heart Failure

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50PubMed
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Articles related to Diastolic Heart Failure:

(show top 50)    (show all 478)
idTitleAuthorsYear
1
Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF). (22983988)
2013
2
Effects of Auto-Servo Ventilation on Patients with Sleep-Disordered Breathing, Stable Systolic Heart Failure and Concomitant Diastolic Dysfunction: Subanalysis of a Randomized Controlled Trial. (24029470)
2013
3
Diastolic heart failure. (23437614)
2013
4
Role of ACE2 in diastolic and systolic heart failure. (21638102)
2012
5
Diastolic dysfunction and abnormal exercise ventilation predict adverse outcome in elderly patients with chronic systolic heart failure. (21450576)
2012
6
Diabetic cardiomyopathy and diastolic heart failure -- difficulties with relaxation. (22502812)
2012
7
Diastolic heart failure: perioperative management. (22735725)
2012
8
Diastolic heart failure: progress, treatment challenges, and prevention. (21601770)
2011
9
Differences in sarcoplasmic reticulum Ca2+ leak characteristics between systolic and diastolic heart failure rabbit models. (21789895)
2011
10
Prediction clinical profile to distinguish between systolic and diastolic heart failure in hospitalized patients. (19393500)
2009
11
Characteristics of myocardial deformation and rotation in subjects with diastolic dysfunction without diastolic heart failure. (20049139)
2009
12
Optimal treatment of hypertension with diastolic heart failure. (18313629)
2008
13
Influence of prosthesis-patient mismatch on diastolic heart failure after aortic valve replacement. (18355517)
2008
14
Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats. (18400557)
2008
15
Cystatin C concentration as a predictor of systolic and diastolic heart failure. (18226769)
2008
16
Left atrial remodeling in patients younger than 70 years with diastolic and systolic heart failure. (17275704)
2007
17
Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. (17283265)
2007
18
Statins and diastolic heart failure. (16740328)
2007
19
Diastolic dysfunction and autonomic abnormalities in patients with systolic heart failure. (17123863)
2007
20
Ventriculovascular coupling in systolic and diastolic heart failure. (17543251)
2006
21
Diastolic heart failure: fact or myth? (17190238)
2006
22
Epidemiology of diastolic heart failure. (16003647)
2005
23
Diastolic heart failure: a review and primary care perspective. (15879566)
2005
24
Therapy for diastolic heart failure. (16115517)
2005
25
Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure; Japanese Diastolic Heart Failure Study (J-DHF). (16198251)
2005
26
Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure. (15604330)
2005
27
Ventricular volume and length in hypertensive diastolic heart failure. (16198882)
2005
28
Role of angiotensin II in the evolution of diastolic heart failure. (16330897)
2005
29
Heart rate variability and diastolic heart failure. (15009853)
2004
30
Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. (14715184)
2004
31
Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure. (15389248)
2004
32
Management of diastolic heart failure. (15627918)
2004
33
Left ventricular diastolic dysfunction and diastolic heart failure. (14746527)
2004
34
Proinflammatory cytokine levels in patients with diastolic heart failure. (15338014)
2004
35
Angiotensin II type 1 and endothelin type A receptor antagonists modulate the extracellular matrix regulatory system differently in diastolic heart failure. (12569276)
2003
36
Heart failure with preserved ejection fraction: is this diastolic heart failure? (12742292)
2003
37
Diastolic heart failure: can we afford to be in diastole? (16352119)
2003
38
Elderly hospitalized patients with diastolic heart failure: lack of gender and ethnic differences in 18-month mortality rates. (12560412)
2003
39
Primary diastolic heart failure. (11986532)
2002
40
New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment. (11914262)
2002
41
Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? (11502702)
2001
42
Systolic versus diastolic heart failure in community practice: clinical features, outcomes, and the use of angiotensin-converting enzyme inhibitors. (11099679)
2000
43
Diastolic heart failure: diagnosis and treatment. (11205721)
2000
44
Diastolic heart failure is an overused diagnosis (10903677)
2000
45
Diastolic heart failure in the community. (10980915)
2000
46
Diagnosis and treatment of diastolic heart failure. (10089929)
1999
47
Neurohormonal mechanisms in congestive heart failure with special reference to diastolic heart failure. (10582468)
1999
48
Diastolic Heart Failure: A Challenge in Clinical Cardiology. Proceedings of a meeting. Lisbon, Portugal, January 23-24, 1998. (10636643)
1999
49
Diastolic ventricular interaction in chronic heart failure: relation to heart rate variability and neurohumoral status. (10651169)
1998
50
Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective. (7594087)
1995

Genetic Variations for Diastolic Heart Failure

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Expression for genes affiliated with Diastolic Heart Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for genes affiliated with Diastolic Heart Failure

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome, 29KEGG
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Pathways related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NOS3
29.6AGT, MAPK8
39.5ACE, MMP9, MMP2
4
Hide members
9.5MMP2, MMP1, MMP9
59.4NOS3, MMP9, MMP2
69.4MMP2, MMP9, NOS3
79.2ACE, MMP9, MMP2, CST3
8
Cell adhesion ECM remodeling
Hide members
9.2CST3, MMP2, MMP1, MMP9
99.1MMP9, MMP2, MAPK8
109.1MMP2, MMP1, MMP9, NOS3
11
Hide members
9.1AGTR1, AGT, MAPK8, NOS3
12
Hide members
9.0MMP9, MMP1, MMP2, LOXL3
13
Development PDGF signaling via STATs and NF-kB
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9.0NOS3, MMP2, MAPK8, AGTR1
148.8NOS3, MMP9, MMP2, MAPK8
15
Development Endothelin-1/EDNRA signaling
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8.6NPPB, MAPK8, MMP2, MMP9, NOS3
16
Hide members
8.6MMP9, MMP1, MMP2, CYBB, MAPK8
17
Hide members
8.3BMP6, AGTR1, AGT, MAPK8, ACE
18
Hide members
7.7BMP6, MAPK8, MMP2, MMP1, MMP9, NOS3

Compounds for genes affiliated with Diastolic Heart Failure

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.3MMP2, CST3
2rosiglitazone44 49 28 11 2414.3MMP1, NPPB
3losartan44 49 28 1113.2AGT, NPPA, NPPB
4procollagen4410.2NPPB
5pge24410.1MMP9, MMP2
6cyclosporin a44 28 5912.1MMP1, NPPB, CST3
7aprotinin44 1111.0MMP1, MMP2, NPPB
8epinephrine44 11 2412.0AGT, AGTR1, NPPA, NPPB
9trandolapril44 1110.9ACE, AGTR1, NPPA, NPPB
10benazepril44 1110.9NPPA, ACE, AGT, AGTR1
11enalaprilat449.8AGT, ACE, NPPB, NPPA
12norepinephrine44 11 2411.8MMP1, BMP6
13valsartan44 59 28 1112.7NPPB, AGTR1, AGT, ACE
14lisinopril44 11 2411.7NPPB, AGTR1, AGT, ACE, NPPA
15ramipril44 1110.7AGTR1, CST3, NPPB, NPPA, ACE
16metoprolol44 28 49 11 2413.7NPPA, NOS3, ACE, NPPB
17chymostatin449.6MMP9, ACE, AGT, AGTR1
18telmisartan44 28 1111.6NPPB, AGT, AGTR1, ACE
19fosinopril44 1110.6AGTR1, NPPA, MMP9, NPPB, ACE
20digoxin44 49 59 11 2413.6NPPB, CST3, NPPA, ACE, AGTR1
21atenolol44 28 49 11 2413.6AGTR1, ACE, MMP2, AGT, NPPB
22carvedilol44 49 28 1112.6NOS3, NPPB, NPPA, ACE, AGTR1
23cgs-27023a449.6MMP1, MMP9, MMP2
24nitroglycerin44 1110.6NPPB, ACE, NOS3, AGTR1, NPPA
25irbesartan44 28 49 1112.4AGTR1, ACE, MMP9, AGT
26perindopril44 49 1111.4NPPA, ACE, AGT, NOS3, NPPB, AGTR1
27amlodipine44 49 11 2412.4NPPB, ACE, AGTR1, AGT, NPPA, NOS3
28l-nmma449.3NPPB, AGT, NOS3, NPPA, MMP9, AGTR1
29geranylgeranyl pyrophosphate449.3AGT, MMP1, MMP9, NOS3
30phenylephrine44 28 11 2412.3AGTR1, AGT, MMP2, NPPA, NPPB, NOS3
318-isoprostane449.2NPPB, AGTR1, CYBB, NOS3, MMP9, MMP2
32haloperidol44 28 2 49 1113.1NPPA, AGTR1, NPPB, PVALB, MMP1, AGT
33candesartan44 28 1111.0NPPB, AGTR1, AGT, MMP2, MMP1, NOS3
34enalapril44 49 1110.9AGT, NPPB, NPPA, BMP6, AGTR1, ACE
35ang ii448.8NOS3, AGT, AGTR1, NPPA, ACE, NPPB
36nifedipine44 49 28 1111.6BMP6, ACE, MMP9, AGT, AGTR1, NPPA
37prostacyclin448.5NPPB, ACE, NOS3, AGT, AGTR1, BMP6
38n acetylcysteine448.4MMP1, MAPK8, AGT, MMP2, AGTR1, CST3
39aspirin44 49 28 2411.4MMP2, AGTR1, NOS3, NPPB, ACE, MMP1
40dexamethasone44 49 28 1111.3MMP9, CYBB, MAPK8, AGT, BMP6, NPPB
41atorvastatin44 49 28 11 2412.3MMP9, NPPB, MMP2, MMP1, NOS3, BMP6
42genistein44 28 59 2 11 2413.2MMP2, MMP9, MMP1, MAPK8, AGT, AGTR1
43acetylcholine44 49 28 11 2412.1AGTR1, NPPB, NOS3, PVALB, AGT, ACE
44serine448.0AGT, AGTR1, MMP9, MMP1, MMP2, CYBB
45nitric oxide44 11 249.6NOS3, ACE, CYBB, AGT, PVALB, NPPB
46pd 98,059447.6BMP6, MMP9, MMP1, AGT, MAPK8, MMP2
47creatinine447.6AGTR1, AGT, MMP2, MMP1, MMP9, ACE
48sb 20358044 598.5MMP1, NPPB, BMP6, AGTR1, AGT, MMP2
49h2o2447.1NOS3, AGTR1, MMP1, BMP6, MAPK8, CYBB
50vegf446.7NPPB, MAPK8, MMP2, CYBB, MMP9, AGT

GO Terms for genes affiliated with Diastolic Heart Failure

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16Gene Ontology
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Cellular components related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8CST3, NPPB, NPPA, AGT, MMP2, MMP1
2extracellular spaceGO:0056157.0ACE, LOXL3, CST3, NPPB, NPPA, BMP6

Biological processes related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.3AGTR1, AGT
4renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, AGT
5regulation of renal output by angiotensinGO:00201910.3ACE, AGT
6regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.2ACE, AGTR1
7positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
8regulation of vasodilationGO:04231210.2ACE, AGTR1, NPPB
9cGMP biosynthetic processGO:00618210.1NPPA, NPPB
10regulation of vasoconstrictionGO:01922910.1ACE, AGT, AGTR1
11receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB
12low-density lipoprotein particle remodelingGO:03437410.0AGT, AGTR1
13positive regulation of cellular protein metabolic processGO:03227010.0AGT, AGTR1
14regulation of blood vessel sizeGO:05088010.0NPPB, NPPA, NOS3
15blood vessel remodelingGO:0019749.9AGT, NOS3, ACE
16regulation of blood pressureGO:0082179.8ACE, NOS3, NPPA, NPPB
17angiotensin maturationGO:0020039.7ACE, AGT
18cellular response to mechanical stimulusGO:0712609.7MAPK8, ANKRD1, AGT
19collagen catabolic processGO:0305749.6MMP9, MMP1, MMP2
20extracellular matrix disassemblyGO:0226179.6MMP2, MMP1, MMP9
21kidney developmentGO:0018229.3BMP6, AGTR1, AGT, ACE
22extracellular matrix organizationGO:0301989.1AGT, MMP2, MMP1, MMP9

Molecular functions related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1titin bindingGO:03143210.1MYBPC3, ANKRD1
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1
3bradykinin receptor bindingGO:0317119.9ACE, AGTR1
4hormone activityGO:0051799.5AGT, NPPA, NPPB

Products for genes affiliated with Diastolic Heart Failure

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Sources for Diastolic Heart Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet