MCID: DST006
MIFTS: 46

Diastolic Heart Failure malady

Categories: Cardiovascular diseases

Aliases & Classifications for Diastolic Heart Failure

Aliases & Descriptions for Diastolic Heart Failure:

Name: Diastolic Heart Failure 12 14
Heart Failure, Diastolic 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9775
ICD10 33 I50.30
ICD9CM 35 428.3 428.30
MeSH 42 D054144
SNOMED-CT 64 418304008
UMLS 69 C1135196

Summaries for Diastolic Heart Failure

MalaCards based summary : Diastolic Heart Failure, also known as heart failure, diastolic, is related to systolic heart failure and myocardial infarction. An important gene associated with Diastolic Heart Failure is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Apelin signaling pathway. The drugs Nitric Oxide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 71 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

Related Diseases for Diastolic Heart Failure

Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 systolic heart failure 29.7 ACE AGT AGTR1
2 myocardial infarction 28.7 ACE AGT AGTR1 MMP2 NOS3 NPPB
3 penile cancer, childhood 10.2 ACE AGT
4 inferolateral myocardial infarct 10.2 ACE NPPB
5 mental retardation hypocupremia hypobetalipoproteinemia 10.2 AGT AGTR1
6 syringomelia hyperkeratosis 10.2 ACE NPPB
7 malignant hyperthermia susceptibility 1 10.2 ACE AGT
8 median neuropathy 10.2 ACE NPPB
9 kartagener syndrome 10.2 ACE NOS3
10 iida kannari syndrome 10.2 ACE NPPB
11 rapidly progressive glomerulonephritis 10.2 ACE NOS3
12 suppurative otitis media 10.1 ACE NPPB
13 histidine metabolism disease 10.1 NOS3 NPPB
14 prostate neuroendocrine neoplasm 10.1 ACE AGT AGTR1
15 preaxial polydactyly of fingers 10.1 ACE AGT AGTR1
16 cascade stomach 10.1 ACE AGT AGTR1
17 hyperuricemic nephropathy, familial juvenile 2 10.1 ACE AGT AGTR1
18 cetp-related hyperalphalipoproteinemia 10.1 ACE AGT AGTR1
19 cardiomyopathy 10.1
20 hypertension, diastolic 10.1
21 flat umbilicus familial 10.1 ACE AGT AGTR1
22 ectodermal dysplasia 9, hair/nail type 10.1 NOS3 NPPB
23 vitreous disease 10.1 NOS3 NPPB
24 familial nephrotic syndrome 10.1 ACE AGT AGTR1
25 petrositis 10.1 ACE AGTR1 NPPB
26 villous adenoma 10.1 ACE NOS3
27 critical limb ischemia 10.1 ACE AGTR1 NPPB
28 ceroid lipofuscinosis, neuronal, kufs type, adult onset 10.1 ACE AGT NPPB
29 familial nasal acilia 10.1 AGT AGTR1
30 adams-oliver syndrome 10.1 ACE AGT NPPB
31 alpha-2-plasmin inhibitor deficiency 10.1 ACE AGTR1 NOS3
32 acute posterior multifocal placoid pigment epitheliopathy 10.1 ACE AGTR1 NOS3
33 aphasia 10.1 ACE NOS3
34 citrullinemia, type ii, neonatal-onset 10.1 ACE AGTR1 NOS3
35 lymphocytic colitis 10.0 ACE MMP2
36 pyelonephritis 10.0 ACE NOS3 NPPB
37 pervasive developmental disorder 10.0 ACE MYBPC3 NPPB
38 welander distal myopathy 10.0 AGT AGTR1 NOS3
39 diabetic encephalopathy 10.0 ACE NOS3 NPPB
40 budd-chiari syndrome 10.0 ACE AGTR1 NOS3
41 lung giant cell carcinoma 10.0 ACE AGTR1 NPPB
42 hypertrichosis of eyelid 10.0 ACE AGTR1 CTGF
43 kidney disease 10.0
44 calcinosis 10.0 ACE AGTR1 CTGF
45 long qt syndrome 9 10.0 ACE MYBPC3 NPPB
46 pulmonary valve insufficiency 10.0 ACE CTGF
47 focal dystonia 10.0 ACE NOS3
48 eastern equine encephalitis 10.0 ACE AGT AGTR1 NPPB
49 endotheliitis 10.0
50 pulmonary hypertension 10.0

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to Diastolic Heart Failure

Symptoms & Phenotypes for Diastolic Heart Failure

MGI Mouse Phenotypes related to Diastolic Heart Failure:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ACE AGT AGTR1 ANKRD1 CTGF MMP2
2 growth/size/body region MP:0005378 9.7 ACE AGT AGTR1 ANKRD1 CTGF MMP2
3 homeostasis/metabolism MP:0005376 9.56 ACE AGT AGTR1 ANKRD1 CTGF MMP2
4 muscle MP:0005369 9.02 AGT ANKRD1 MMP2 MYBPC3 NOS3

Drugs & Therapeutics for Diastolic Heart Failure

Drugs for Diastolic Heart Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 417)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
2
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
3
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
4
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
5
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
6
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
7
Candesartan Approved Phase 4,Phase 3,Phase 2 139481-59-7 2541
8
Carvedilol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 72956-09-3 2585
9
Bisoprolol Approved Phase 4,Phase 1,Phase 2 66722-44-9 2405
10
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 37350-58-6, 51384-51-1 4171
11
Diltiazem Approved Phase 4,Phase 1 42399-41-7 39186
12
Deferoxamine Approved, Investigational Phase 4 70-51-9 2973
13
Adalimumab Approved Phase 4 331731-18-1 16219006
14
Etanercept Approved, Investigational Phase 4 185243-69-0
15
Infliximab Approved Phase 4 170277-31-3
16
Abciximab Approved Phase 4 143653-53-6
17
Deferiprone Approved Phase 4 30652-11-0 2972
18
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
19
Fluorouracil Approved Phase 4 51-21-8 3385
20
Epirubicin Approved Phase 4 56420-45-2 41867
21
Ethanol Approved Phase 4,Phase 3 64-17-5 702
22
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
23
Zinc Approved Phase 4,Phase 2,Phase 1 7440-66-6 32051 23994
24
Digoxin Approved Phase 4,Phase 2 20830-75-5 30322 2724385
25
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
26
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 2 54-31-9 3440
27
Glimepiride Approved Phase 4,Phase 3 93479-97-1 3476
28
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
29
Ramipril Approved Phase 4,Phase 3 87333-19-5 5362129
30
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
31
Losartan Approved Phase 4,Phase 3,Phase 1 114798-26-4 3961
32
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
33
Valsartan Approved, Investigational Phase 4,Phase 3,Phase 2 137862-53-4 60846
34
Amlodipine Approved Phase 4,Phase 3,Phase 2 88150-42-9 2162
35
Eplerenone Approved Phase 4,Phase 2,Phase 3,Phase 1 107724-20-9 150310 443872
36
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
37
Nebivolol Approved, Investigational Phase 4,Phase 1 152520-56-4, 99200-09-6, 118457-14-0 71301
38
Allopurinol Approved Phase 4 315-30-0 2094
39
Amiloride Approved Phase 4,Phase 1 2016-88-8, 2609-46-3 16231
40
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
41
Dobutamine Approved Phase 4,Phase 3,Phase 2 34368-04-2 36811
42
Conivaptan Approved, Investigational Phase 4 210101-16-9 151171
43
Exenatide Approved, Investigational Phase 4,Phase 3 141758-74-9 15991534
44
Tadalafil Approved, Investigational Phase 4,Phase 1,Phase 2 171596-29-5 110635
45
Menthol Approved Phase 4,Phase 2,Early Phase 1 2216-51-5 16666
46
Insulin Glargine Approved Phase 4 160337-95-1
47
Regadenoson Approved Phase 4 313348-27-5 219024
48
Canagliflozin Approved Phase 4 842133-18-0
49
Empagliflozin Approved Phase 4,Phase 3,Phase 2 864070-44-0
50
Insulin Aspart Approved Phase 4 116094-23-6 16132418

Interventional clinical trials:

(show top 50) (show all 581)
id Name Status NCT ID Phase
1 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy Unknown status NCT01293903 Phase 4
2 Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure Unknown status NCT01156207 Phase 4
3 Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant Unknown status NCT00552851 Phase 4
4 A Study of Liposomal Doxorubicin in Women With Breast Cancer Exploiting Tissue Doppler Imaging Unknown status NCT00531973 Phase 4
5 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4
6 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy Unknown status NCT00879060 Phase 4
7 Combined Chelation Treatment With Deferiprone and Deferoxamine in Thalassemia Major Unknown status NCT00103753 Phase 4
8 Intracoronary Bolus Only Compared With Intravenous Bolus and 12-hours Infusion of Abciximab in Non-ST Elevation Myocardial Infarction. Unknown status NCT01080638 Phase 4
9 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4
10 A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial) Unknown status NCT01589380 Phase 4
11 Novel Treatment for Diastolic Heart Failure in Women Completed NCT00206232 Phase 4
12 Aldosterone Antagonism in Diastolic Heart Failure Completed NCT00108251 Phase 4
13 SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) Completed NCT01046838 Phase 4
14 Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart Completed NCT01944384 Phase 4
15 A Trial of Fimasartan for Early Diastolic Heart Failure Completed NCT01691118 Phase 4
16 Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure Completed NCT00171106 Phase 4
17 Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients Completed NCT00477789 Phase 4
18 Heart Failure With Normal Ejection Fraction (HFNEF) in Hemodialysed Patients: Beneficial Effect of Ivabradine Completed NCT01373619 Phase 4
19 The VALIDATE Study of Valsartan for Patients With Early Stage Heart Failure Completed NCT00241098 Phase 4
20 The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Failure Completed NCT00082589 Phase 4
21 Efficacy Study of Digoxin & Ivabradine to Treat Heart Failure Completed NCT01699776 Phase 4
22 Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure Completed NCT01261065 Phase 4
23 Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure Completed NCT00733161 Phase 4
24 Effects of Viagra on Heart Function in Patients With Heart Failure Completed NCT00781508 Phase 4
25 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4
26 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4
27 Effects of Carvedilol on Health Outcomes in Heart Failure Completed NCT00381030 Phase 4
28 Effects of Exenatide in Type 2 Diabetic Patients With Congestive Heart Failure Completed NCT00766857 Phase 4
29 To Evaluate the Efficacy and Safety on Blood Pressure In Patients With Hypertension Diagnosed Congestive Heart Failure Completed NCT01682564 Phase 4
30 Assessment of Hemodynamic Response in Cardiopulmonary Bypass Graft After Cardiopulmonary Bypass Using Transesophegeal Echocardiography Completed NCT01616069 Phase 4
31 Effects on Exercise Hemodynamics of Vasopressin Blockade by Conivaptan Infusion in Heart Failure Patients Completed NCT01752543 Phase 4
32 Statin Therapy in Heart Failure: Potential Mechanisms of Benefit Completed NCT00233480 Phase 4
33 Association Between Genetic Polymorphism of Beta-adrenergic Receptor and Effects of Bisoprolol in Korean Heart Failure Patients. Completed NCT01104558 Phase 4
34 Angiotensin-II Blockade in Mitral Regurgitation Completed NCT00587470 Phase 4
35 Study to Characterize Atrial Fibrillation in CHF Patients Indicated for CRT Completed NCT00156728 Phase 4
36 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
37 Clinical Evaluation on Advanced Resynchronization Completed NCT00658203 Phase 4
38 Chronic, Low Dose Erythropoetin Beta in Ischemic Cardiomyopathy Completed NCT00568542 Phase 4
39 Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Completed NCT01060020 Phase 4
40 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4
41 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4
42 Statin Therapy In Atrial Refractoriness and Reperfusion Injury Completed NCT01780740 Phase 4
43 Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation Completed NCT00307463 Phase 4
44 Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study Completed NCT01951404 Phase 4
45 Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure Recruiting NCT02053246 Phase 4
46 Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF Recruiting NCT02589977 Phase 4
47 Effects of Atorvastatin Treatment on Left Ventricular Diastolic Function in Peritoneal Dialysis Patients Recruiting NCT01503671 Phase 4
48 Diabetes Interventional Assessment of Slimming or Training to Lessen Inconspicuous Cardiovascular Dysfunction Recruiting NCT02590822 Phase 4
49 Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension Recruiting NCT02973035 Phase 4
50 Assessment of Cardiac Resynchronization Therapy in Patients With Wide QRS and Non-specific Intraventricular Conduction Delay: a Randomized Trial Recruiting NCT02454439 Phase 4

Search NIH Clinical Center for Diastolic Heart Failure

Cochrane evidence based reviews: heart failure, diastolic

Genetic Tests for Diastolic Heart Failure

Anatomical Context for Diastolic Heart Failure

MalaCards organs/tissues related to Diastolic Heart Failure:

39
Heart, Lung, Brain, Kidney, Testes, Endothelial

Publications for Diastolic Heart Failure

Articles related to Diastolic Heart Failure:

(show top 50) (show all 447)
id Title Authors Year
1
Diastolic heart failure: diagnosis and therapy. ( 26658178 )
2016
2
The Stiff Left Atrium Is to Atrial Fibrillation as the Stiff Left Ventricle Is to Diastolic Heart Failure. ( 26966289 )
2016
3
Diastolic Heart Failure Predicted by Left Atrial Expansion Index in Patients with Severe Diastolic Dysfunction. ( 27622475 )
2016
4
Deliberations on Diastolic Heart Failure. ( 28029360 )
2016
5
Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial. ( 27072860 )
2016
6
Clinical effects of combined treatment by optimal dose of furosemide and spironolactone on diastolic heart failure in elderly patients. ( 26998008 )
2016
7
Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case-control study. ( 26861937 )
2016
8
Lowering body weight in obese mice with diastolic heart failure improves cardiac insulin sensitivity and function: implications for the obesity paradox. ( 25524917 )
2015
9
Successful resection of a huge metastatic liposarcoma in the pericardium resulting in improvement of diastolic heart failure: a case report. ( 26366370 )
2015
10
Increased Prevalence of Diastolic Heart Failure in Patients with Rheumatoid Arthritis Correlates with Active Disease, but Not with Treatment Type. ( 26373561 )
2015
11
Complete heart block with diastolic heart failure and pulmonary edema secondary to enlarging previously diagnosed thrombosed aneurysm of sinus of valsalva in a patient with history of autosomal dominant polycystic kidney disease. ( 25861484 )
2015
12
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice. ( 26461521 )
2015
13
Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). ( 25742762 )
2015
14
Constrictive pericarditis-a curable diastolic heart failure. ( 26440983 )
2015
15
The association and interaction analysis of hypertension and diabetes mellitus on diastolic heart failure in a high-risk population. ( 26885071 )
2015
16
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. ( 26142467 )
2015
17
Impact of the renin-angiotensin system and inflammatory gene polymorphisms on diastolic heart failure. ( 24530241 )
2014
18
Optimising exercise training in prevention and treatment of diastolic heart failure (OptimEx-CLIN): rationale and design of a prospective, randomised, controlled trial. ( 25354950 )
2014
19
Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1): A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study. ( 24991733 )
2014
20
Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models. ( 24464932 )
2014
21
New diagnostic and therapeutic possibilities for diastolic heart failure. ( 24494212 )
2014
22
CrossTalk opposing view: the late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488067 )
2014
23
CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction). ( 24488066 )
2014
24
Genetics of systolic and diastolic heart failure. ( 25380161 )
2014
25
Digoxin and 30-day All-cause Hospital Admission in Older Patients with Chronic Diastolic Heart Failure. ( 24067296 )
2014
26
Myocardial energetics and ubiquinol in diastolic heart failure. ( 25263245 )
2014
27
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats. ( 24759122 )
2014
28
Socioeconomic factors and mortality in diastolic heart failure. ( 24467732 )
2014
29
Association and predictive value analysis for metabolic syndrome on systolic and diastolic heart failure in high-risk patients. ( 25249273 )
2014
30
Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure. ( 25267798 )
2014
31
Constrictive pericarditis--a curable diastolic heart failure. ( 25072910 )
2014
32
Case 6/2014--A case of a 61-year-old woman with diastolic heart failure. ( 25590936 )
2014
33
Utility of lower limb positive pressure test for diagnosis of diastolic heart failure: a case report. ( 25264062 )
2014
34
Heart failure with normal ejection fraction, heart failure with preserved ejection fraction, diastolic heart failure, or huff-puff: time for a new taxonomy for hypertensive-metabolic heart failure. ( 25151212 )
2014
35
Relaxin levels in pulmonary hypertension: a comparison between pulmonary arterial hypertension and diastolic heart failure-induced pulmonary hypertension. ( 23273743 )
2013
36
Association and interaction analysis of metabolic syndrome and serum uric acid on diastolic heart failure. ( 23404264 )
2013
37
Design and rationale of studies of neurohormonal blockade and outcomes in diastolic heart failure using OPTIMIZE-HF registry linked to Medicare data. ( 22119116 )
2013
38
Diastolic Heart Failure in Hypertension: Possible Preventive Benefits of Nebivolol Beyond Lowering Blood Pressure. ( 24371501 )
2013
39
Combination of B-type natriuretic peptide and minute ventilation/carbon dioxide production slope improves risk stratification in patients with diastolic heart failure. ( 21807423 )
2013
40
Genetics of diastolic heart failure. ( 24220586 )
2013
41
Diastolic heart failure. ( 23437614 )
2013
42
Defining diastolic heart failure and identifying effective therapies. ( 23443447 )
2013
43
Triple-trouble cardiomyopathy: myocardial infarction, diastolic heart failure, and conduction defects due to amyloidosis associated with multiple myeloma. ( 23788103 )
2013
44
RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study. ( 24621836 )
2013
45
Cognitive profile in persons with systolic and diastolic heart failure. ( 22958577 )
2013
46
The association and predictive value analysis of metabolic syndrome on diastolic heart failure in patients at high risk for coronary artery disease. ( 23800086 )
2013
47
Diastolic heart failure: a concise review. ( 23986796 )
2013
48
Tissue Doppler-derived E/e' ratio as a parameter for assessing diastolic heart failure and as a predictor of mortality in patients with chronic kidney disease. ( 23345995 )
2013
49
Comparison between ivabradine and low-dose digoxin in the therapy of diastolic heart failure with preserved left ventricular systolic function. ( 24765517 )
2013
50
Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF). ( 22983988 )
2013

Variations for Diastolic Heart Failure

Expression for Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for Diastolic Heart Failure

GO Terms for Diastolic Heart Failure

Cellular components related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ACE AGT CTGF MMP2 NPPB
2 sarcomere GO:0030017 8.8 ANKRD1 MMP2 MYBPC3

Biological processes related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.81 CTGF MMP2 NOS3
2 kidney development GO:0001822 9.73 ACE AGT AGTR1
3 regulation of lipid metabolic process GO:0019216 9.71 AGT ANKRD1 CTGF
4 regulation of cell growth GO:0001558 9.7 AGT AGTR1 CTGF
5 sarcomere organization GO:0045214 9.64 ANKRD1 MYBPC3
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.63 AGT AGTR1
7 positive regulation of protein tyrosine kinase activity GO:0061098 9.63 ACE AGT
8 positive regulation of vasodilation GO:0045909 9.62 AGT NOS3
9 vasodilation GO:0042311 9.62 AGT NOS3
10 nitric oxide mediated signal transduction GO:0007263 9.61 AGT NOS3
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.61 AGT MMP2
12 positive regulation of cellular protein metabolic process GO:0032270 9.6 AGT AGTR1
13 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.59 AGT AGTR1
14 low-density lipoprotein particle remodeling GO:0034374 9.58 AGT AGTR1
15 positive regulation of renal sodium excretion GO:0035815 9.58 AGT NPPB
16 blood vessel remodeling GO:0001974 9.58 ACE AGT NOS3
17 angiotensin maturation GO:0002003 9.57 ACE AGT
18 positive regulation of cholesterol esterification GO:0010873 9.55 AGT AGTR1
19 regulation of vasoconstriction GO:0019229 9.54 ACE AGT AGTR1
20 positive regulation of NAD(P)H oxidase activity GO:0033864 9.51 AGT AGTR1
21 regulation of blood vessel size GO:0050880 9.5 AGT NOS3 NPPB
22 renin-angiotensin regulation of aldosterone production GO:0002018 9.49 AGT AGTR1
23 regulation of renal sodium excretion GO:0035813 9.48 AGT AGTR1
24 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.46 AGT AGTR1
25 regulation of blood pressure GO:0008217 9.46 ACE AGT NOS3 NPPB
26 regulation of renal output by angiotensin GO:0002019 9.43 ACE AGT
27 regulation of vasodilation GO:0042312 9.43 ACE AGTR1 NPPB
28 regulation of blood vessel diameter GO:0097746 9.13 ACE AGTR1 NPPB
29 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.8 ACE AGT AGTR1

Molecular functions related to Diastolic Heart Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 titin binding GO:0031432 8.96 ANKRD1 MYBPC3
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Diastolic Heart Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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