MCID: DST006
MIFTS: 52

Diastolic Heart Failure malady

Summaries for Diastolic Heart Failure

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

MalaCards: Diastolic Heart Failure, also known as heart failure, diastolic, is related to hypertension and congestive heart failure. An important gene associated with Diastolic Heart Failure is ANKRD1 (ankyrin repeat domain 1 (cardiac muscle)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The compounds captopril and rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Diastolic Heart Failure

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT
See all sources

Aliases & Descriptions:

diastolic heart failure 8 10
heart failure, diastolic 60


External Ids:

Disease Ontology8 DOID:9775
MeSH34 D054144
SNOMED-CT56 418304008
ICD9CM27 428.30, 428.3

Related Diseases for Diastolic Heart Failure

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3CST3, NPPB, NPPA, AGTR1, AGT, MMP9
2congestive heart failure30.6NPPB, NPPA, AGTR1, AGT, ACE
3chronic kidney failure30.6CST3, NPPB, NPPA, AGTR1, AGT, NOS3
4amyloidosis30.5NPPB, CST3
5myeloma30.5MAPK8, CST3
6hypertensive heart disease30.5NPPB, NPPA, AGTR1, MMP1, ACE
7hypertrophic cardiomyopathy30.4MYBPC3
8myocarditis30.4NPPB
9coronary artery disease30.4CST3, ACE, NOS3, MMP9, CYBB, AGT
10familial hypertrophic cardiomyopathy30.2MYBPC3
11myocardial infarction30.1CST3, NPPB, NPPA, AGTR1, AGT, NOS3
12ischemia30.1PVALB, CST3, NPPB, AGT, MAPK8, NOS3
13vascular disease30.1CST3, BMP6, AGTR1, AGT, CYBB, MMP9
14diabetes mellitus30.1CST3, NPPB, NPPA, AGTR1, AGT, MAPK8
15atherosclerosis30.1CST3, BMP6, AGTR1, AGT, MAPK8, CYBB
16systolic heart failure11.0
17kidney disease10.4
18renal hypertension10.4
19acute myocarditis10.3
20multiple myeloma10.3
21peripheral vascular disease10.1
22cardiac tamponade10.1
23mixed connective tissue disease10.1
24cerebritis10.1
25systemic lupus erythematosus10.1
26heart lymphoma10.1
27peripartum cardiomyopathy10.1
28constrictive pericarditis10.1
29connective tissue disease10.1
30lupus erythematosus10.1
31pericarditis10.1
32respiratory failure10.1
33restrictive cardiomyopathy10.1
34sleep disorder10.1
35mitral valve prolapse10.0AGTR1
36central sleep apnea10.0NPPB
37pulmonary embolism10.0NPPB
38nephritis10.0ACE
39mitral valve disease10.0NPPA
40oligohydramnios10.0ACE
41anuria10.0ACE
42ureteral obstruction10.0AGTR1
43gitelman syndrome10.0AGT
44glaucoma10.0MMP1
45sick sinus syndrome10.0NPPA
46hepatorenal syndrome10.0NPPA
47hepatopulmonary syndrome10.0NOS3
48chagas disease10.0NPPB
49sickle cell disease10.0NOS3
50synovitis10.0MMP1

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to diastolic heart failure

Clinical Features for Diastolic Heart Failure

About this section

Drugs & Therapeutics for Diastolic Heart Failure

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diastolic Heart Failure

Drug clinical trials:

Search ClinicalTrials for Diastolic Heart Failure

Search NIH Clinical Center for Diastolic Heart Failure

Search CenterWatch for Diastolic Heart Failure

Genetic Tests for Diastolic Heart Failure

About this section

Anatomical Context for Diastolic Heart Failure

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Diastolic Heart Failure:

32
Heart, Lung, Brain, Kidney, Endothelial, Testes

Animal Models for Diastolic Heart Failure or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Diastolic Heart Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.6AGTR1, AGT, CYBB, ACE
2MP:00020068.7CST3, MAPK8, CYBB, MMP9
3MP:00053768.5CST3, NPPA, AGTR1, AGT, MYBPC3, CYBB
4MP:00053857.8AGTR1, NPPA, NPPB, CST3, AGT, MAPK8
5MP:00053867.5AGT, MADD, MAPK8, MYBPC3, CYBB, MMP9
6MP:00053696.9NOS3, PVALB, CST3, NPPB, NPPA, AGT
7MP:00053786.7BMP6, AGTR1, AGT, MAPK8, MYBPC3, CYBB

Publications for Diastolic Heart Failure

About this section
Sources:
50PubMed
See all sources

Articles related to Diastolic Heart Failure:

(show top 50)    (show all 478)
idTitleAuthorsYear
1
Combination of B-type natriuretic peptide and minute ventilation/carbon dioxide production slope improves risk stratification in patients with diastolic heart failure. (21807423)
2013
2
Diastolic function assessed from tagged MRI predicts heart failure and atrial fibrillation over an 8-year follow-up period: the multi-ethnic study of atherosclerosis. (24145457)
2013
3
Diastolic Heart Failure in Hypertension: Possible Preventive Benefits of Nebivolol Beyond Lowering Blood Pressure. (24371501)
2013
4
Heart rate variability in patients hospitalized for decompensated diastolic heart failure at admission and after clinical stabilization. (22642636)
2012
5
Usefulness of Doppler echocardiographic left ventricular diastolic function and peak exercise oxygen consumption to predict cardiovascular outcomes in patients with systolic heart failure (from HF-ACTION). (22683041)
2012
6
Diastolic heart failure and LV dyssynchrony. (22280429)
2012
7
Cardiotrophin-1 plasma levels are increased in patients with diastolic heart failure. (22207116)
2012
8
Demonstrating the pharmacogenetic effects of angiotensin-converting enzyme inhibitors on long-term prognosis of diastolic heart failure. (19752885)
2010
9
Statin therapy in patients with diastolic heart failure. (20127896)
2010
10
Diastolic heart failure in elderly: the prognostic factors and interventions regarding heart failure with preserved ejection fraction. (18845346)
2010
11
Prevalence and predictors of pulmonary hypertension in elderly patients with isolated diastolic heart failure. (20806196)
2010
12
Hypertension and diastolic heart failure. (19863866)
2009
13
Novel strategies for the detection of systolic and diastolic heart failure. (20436851)
2009
14
Left ventricular systolic function is abnormal in diastolic heart failure: re-assessment of systolic function using cardiac time interval analysis. (19477388)
2009
15
The prevalence, clinical characteristics, and prognosis of diastolic heart failure: a clinical study in elderly Saudi patients with up to 5 years follow-up. (19522960)
2009
16
Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure. (19255799)
2009
17
A propensity score-based case-control study of renin-angiotensin system gene polymorphisms and diastolic heart failure. (19185300)
2009
18
Left atrial function in diastolic heart failure. (19808559)
2009
19
Relationship of Doppler-Echocardiographic left ventricular diastolic function to exercise performance in systolic heart failure: the HF-ACTION study. (19782788)
2009
20
C-reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study. (18160340)
2008
21
Attenuation of diastolic heart failure and life-threatening ventricular tachyarrhythmia after peripheral blood stem cell transplantation combined with cardioverter-defibrillator implantation in myeloma-associated cardiac amyloidosis. (18219175)
2008
22
Recognition of diastolic heart failure in the postoperative heart. (18579400)
2008
23
Diastolic heart failure. (18992623)
2008
24
Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure. (18385117)
2008
25
Predictive value of high sensitivity CRP in patients with diastolic heart failure. (17467828)
2008
26
Diastolic heart failure in diabetics. (18437039)
2008
27
Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure. (17512359)
2007
28
Diastolic heart failure: perception of the syndrome and scope of the problem. (17084176)
2006
29
Increased left atrial volume index is an independent predictor of raised serum natriuretic peptide in patients with suspected heart failure but normal left ventricular ejection fraction: Implication for diagnosis of diastolic heart failure. (16115798)
2006
30
Diastolic heart failure or heart failure with a normal ejection fraction. (17167383)
2006
31
Elevated BNP with normal systolic function in asymptomatic individuals at-risk for heart failure: a marker of diastolic dysfunction and clinical risk. (17312822)
2006
32
Treating diastolic heart failure with AGE crosslink breakers: thinking outside the heart failure box. (15812747)
2005
33
Diagnostic criteria for diastolic heart failure. (16003646)
2005
34
Ventriculovascular coupling in systolic and diastolic heart failure. (16332314)
2005
35
Prognosis in diastolic heart failure. (16003648)
2005
36
Treating diastolic heart failure with statins: "phat" chance for pleiotropic benefits. (16027268)
2005
37
Diastolic heart failure in female patient 20 years after radiotherapy due to Hodgkin's disease-a case report. (14975568)
2004
38
Beta-blocker improves survival, left ventricular function, and myocardial remodeling in hypertensive rats with diastolic heart failure. (15607617)
2004
39
Angiotensin II type 1 receptor blockade prevents diastolic heart failure through modulation of Ca(2+) regulatory proteins and extracellular matrix. (12923407)
2003
40
Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure in elderly patients. (12877761)
2003
41
Treatment of diastolic heart failure. (11888037)
2002
42
Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance. (11527636)
2001
43
Use of digoxin in diastolic heart failure. (11574822)
2001
44
Diastolic heart failure. Constrictive, restrictive, and pericardial. (10986586)
2000
45
Pressure-volume relationships in pediatric systolic and diastolic heart failure. (10978714)
2000
46
Diastolic heart failure: miles to go before we sleep. (11099690)
2000
47
Treating diastolic heart failure: the role of calcium antagonists. (10582472)
1999
48
Diastolic heart failure: identification and characterization. Doppler tissue imaging: a "new" approach. (10582452)
1999
49
Paracrine coronary endothelial modulation of diastolic left ventricular function in man: implications for diastolic heart failure. (8951574)
1996
50
Abnormal intracellular calcium handling in acute and chronic heart failure: role in systolic and diastolic dysfunction. (2188844)
1990

Genetic Variations for Diastolic Heart Failure

About this section

Expression for genes affiliated with Diastolic Heart Failure

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for genes affiliated with Diastolic Heart Failure

About this section
Sources:
49PharmGKB, 37NCBI BioSystems Database, 52R&D Systems, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome, 29KEGG
See all sources

Pathways related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NOS3
29.6AGT, MAPK8
39.5ACE, MMP9, MMP2
4
Hide members
9.5MMP2, MMP1, MMP9
59.4NOS3, MMP9, MMP2
69.4MMP2, MMP9, NOS3
79.2ACE, MMP9, MMP2, CST3
8
Cell adhesion ECM remodeling
Hide members
9.2CST3, MMP2, MMP1, MMP9
99.1MMP9, MMP2, MAPK8
109.1MMP2, MMP1, MMP9, NOS3
11
Hide members
9.1AGTR1, AGT, MAPK8, NOS3
12
Hide members
9.0MMP9, MMP1, MMP2, LOXL3
13
Development PDGF signaling via STATs and NF-kB
Hide members
9.0NOS3, MMP2, MAPK8, AGTR1
148.8NOS3, MMP9, MMP2, MAPK8
15
Development Endothelin-1/EDNRA signaling
Hide members
8.6NPPB, MAPK8, MMP2, MMP9, NOS3
16
Hide members
8.6MMP9, MMP1, MMP2, CYBB, MAPK8
17
Hide members
8.3BMP6, AGTR1, AGT, MAPK8, ACE
18
Hide members
7.7BMP6, MAPK8, MMP2, MMP1, MMP9, NOS3

Compounds for genes affiliated with Diastolic Heart Failure

About this section
Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.3MMP2, CST3
2rosiglitazone44 49 28 11 2414.3MMP1, NPPB
3losartan44 49 28 1113.2AGT, NPPA, NPPB
4procollagen4410.2NPPB
5pge24410.1MMP9, MMP2
6cyclosporin a44 28 5912.1MMP1, NPPB, CST3
7aprotinin44 1111.0MMP1, MMP2, NPPB
8epinephrine44 11 2412.0AGT, AGTR1, NPPA, NPPB
9trandolapril44 1110.9ACE, AGTR1, NPPA, NPPB
10benazepril44 1110.9NPPA, ACE, AGT, AGTR1
11enalaprilat449.8AGT, ACE, NPPB, NPPA
12norepinephrine44 11 2411.8MMP1, BMP6
13valsartan44 59 28 1112.7NPPB, AGTR1, AGT, ACE
14lisinopril44 11 2411.7NPPB, AGTR1, AGT, ACE, NPPA
15ramipril44 1110.7AGTR1, CST3, NPPB, NPPA, ACE
16metoprolol44 28 49 11 2413.7NPPA, NOS3, ACE, NPPB
17chymostatin449.6MMP9, ACE, AGT, AGTR1
18telmisartan44 28 1111.6NPPB, AGT, AGTR1, ACE
19fosinopril44 1110.6AGTR1, NPPA, MMP9, NPPB, ACE
20digoxin44 49 59 11 2413.6NPPB, CST3, NPPA, ACE, AGTR1
21atenolol44 28 49 11 2413.6AGTR1, ACE, MMP2, AGT, NPPB
22carvedilol44 49 28 1112.6NOS3, NPPB, NPPA, ACE, AGTR1
23cgs-27023a449.6MMP1, MMP9, MMP2
24nitroglycerin44 1110.6NPPB, ACE, NOS3, AGTR1, NPPA
25irbesartan44 28 49 1112.4AGTR1, ACE, MMP9, AGT
26perindopril44 49 1111.4NPPA, ACE, AGT, NOS3, NPPB, AGTR1
27amlodipine44 49 11 2412.4NPPB, ACE, AGTR1, AGT, NPPA, NOS3
28l-nmma449.3NPPB, AGT, NOS3, NPPA, MMP9, AGTR1
29geranylgeranyl pyrophosphate449.3AGT, MMP1, MMP9, NOS3
30phenylephrine44 28 11 2412.3AGTR1, AGT, MMP2, NPPA, NPPB, NOS3
318-isoprostane449.2NPPB, AGTR1, CYBB, NOS3, MMP9, MMP2
32haloperidol44 28 2 49 1113.1NPPA, AGTR1, NPPB, PVALB, MMP1, AGT
33candesartan44 28 1111.0NPPB, AGTR1, AGT, MMP2, MMP1, NOS3
34enalapril44 49 1110.9AGT, NPPB, NPPA, BMP6, AGTR1, ACE
35ang ii448.8NOS3, AGT, AGTR1, NPPA, ACE, NPPB
36nifedipine44 49 28 1111.6BMP6, ACE, MMP9, AGT, AGTR1, NPPA
37prostacyclin448.5NPPB, ACE, NOS3, AGT, AGTR1, BMP6
38n acetylcysteine448.4MMP1, MAPK8, AGT, MMP2, AGTR1, CST3
39aspirin44 49 28 2411.4MMP2, AGTR1, NOS3, NPPB, ACE, MMP1
40dexamethasone44 49 28 1111.3MMP9, CYBB, MAPK8, AGT, BMP6, NPPB
41atorvastatin44 49 28 11 2412.3MMP9, NPPB, MMP2, MMP1, NOS3, BMP6
42genistein44 28 59 2 11 2413.2MMP2, MMP9, MMP1, MAPK8, AGT, AGTR1
43acetylcholine44 49 28 11 2412.1AGTR1, NPPB, NOS3, PVALB, AGT, ACE
44serine448.0AGT, AGTR1, MMP9, MMP1, MMP2, CYBB
45nitric oxide44 11 249.6NOS3, ACE, CYBB, AGT, PVALB, NPPB
46pd 98,059447.6BMP6, MMP9, MMP1, AGT, MAPK8, MMP2
47creatinine447.6AGTR1, AGT, MMP2, MMP1, MMP9, ACE
48sb 20358044 598.5MMP1, NPPB, BMP6, AGTR1, AGT, MMP2
49h2o2447.1NOS3, AGTR1, MMP1, BMP6, MAPK8, CYBB
50vegf446.7NPPB, MAPK8, MMP2, CYBB, MMP9, AGT

GO Terms for genes affiliated with Diastolic Heart Failure

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8CST3, NPPB, NPPA, AGT, MMP2, MMP1
2extracellular spaceGO:0056157.0ACE, LOXL3, CST3, NPPB, NPPA, BMP6

Biological processes related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.3AGTR1, AGT
4renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, AGT
5regulation of renal output by angiotensinGO:00201910.3ACE, AGT
6regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.2ACE, AGTR1
7positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
8regulation of vasodilationGO:04231210.2ACE, AGTR1, NPPB
9cGMP biosynthetic processGO:00618210.1NPPA, NPPB
10regulation of vasoconstrictionGO:01922910.1ACE, AGT, AGTR1
11receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB
12low-density lipoprotein particle remodelingGO:03437410.0AGT, AGTR1
13positive regulation of cellular protein metabolic processGO:03227010.0AGT, AGTR1
14regulation of blood vessel sizeGO:05088010.0NPPB, NPPA, NOS3
15blood vessel remodelingGO:0019749.9AGT, NOS3, ACE
16regulation of blood pressureGO:0082179.8ACE, NOS3, NPPA, NPPB
17angiotensin maturationGO:0020039.7ACE, AGT
18cellular response to mechanical stimulusGO:0712609.7MAPK8, ANKRD1, AGT
19collagen catabolic processGO:0305749.6MMP9, MMP1, MMP2
20extracellular matrix disassemblyGO:0226179.6MMP2, MMP1, MMP9
21kidney developmentGO:0018229.3BMP6, AGTR1, AGT, ACE
22extracellular matrix organizationGO:0301989.1AGT, MMP2, MMP1, MMP9

Molecular functions related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1titin bindingGO:03143210.1MYBPC3, ANKRD1
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1
3bradykinin receptor bindingGO:0317119.9ACE, AGTR1
4hormone activityGO:0051799.5AGT, NPPA, NPPB

Products for genes affiliated with Diastolic Heart Failure

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diastolic Heart Failure

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet