MCID: DST006
MIFTS: 55

Diastolic Heart Failure malady

Cardiovascular diseases category

Summaries for Diastolic Heart Failure

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66Wikipedia, 34MalaCards
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Wikipedia:66 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

MalaCards: Diastolic Heart Failure, also known as heart failure, diastolic, is related to hypertension and congestive heart failure. An important gene associated with Diastolic Heart Failure is ANKRD1 (ankyrin repeat domain 1 (cardiac muscle)), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The compounds trandolapril and benazepril have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Diastolic Heart Failure

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 28ICD9CM, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

diastolic heart failure 9 11
heart failure, diastolic 63


External Ids:

Disease Ontology9 DOID:9775
ICD9CM28 428.3, 428.30
SNOMED-CT59 418304008
MeSH36 D054144

Related Diseases for Diastolic Heart Failure

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18GeneCards, 19GeneDecks
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Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 138)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3AGTR1, AGT, NPPB, CST3, NPPA, MMP9
2congestive heart failure30.6AGT, AGTR1, NPPB, NPPA, ACE
3hypertensive heart disease30.6NPPB, NPPA, ACE, AGTR1, MMP1
4coronary artery disease30.4ACE, CST3, NOS3, NPPB, AGT, AGTR1
5vascular disease30.3MAPK8, MMP2
6familial hypertrophic cardiomyopathy30.3MYBPC3, TTN
7insulin resistance30.2MAPK8, ACE, AGTR1, AGT, NOS3
8myocardial infarction30.1NPPB, ACE, CST3, NOS3, NPPA, AGTR1
9ischemia30.1NPPB, CST3, MAPK8, TTN, NOS3, AGT
10diabetes mellitus30.0MMP9, CST3, NOS3, NPPA, NPPB, AGT
11atherosclerosis29.8CYBB, MMP9, MMP2, MMP1, ACE, BMP6
12hypertension, diastolic10.6
13kidney disease10.5
14endotheliitis10.5
15amyloidosis10.4
16myeloma10.4
17hypertrophic cardiomyopathy10.3
18acute myocarditis10.3
19artery disease10.3
20multiple myeloma10.3
21myocarditis10.3
22blindness10.3
23peripheral vascular disease10.2
24cardiac tamponade10.2
25obstructive sleep apnea10.2
26peripartum cardiomyopathy10.2
27systolic heart failure10.2
28constrictive pericarditis10.2
29mixed connective tissue disease10.2
30cerebritis10.2
31systemic lupus erythematosus10.2
32connective tissue disease10.2
33lupus erythematosus10.2
34pericarditis10.2
35renal hypertension10.2
36restrictive cardiomyopathy10.2
37sleep apnea10.2
38sleep disorder10.2
39left ventricular outflow tract obstruction10.2
40adiponectin deficiency10.2
41central sleep apnea10.1NPPB
42mitral valve disease10.1NPPA
43sick sinus syndrome10.1NPPA
44hepatorenal syndrome10.1NPPA
45mitral valve prolapse10.1AGTR1
46gitelman syndrome10.1AGT
47oral submucous fibrosis10.1MMP1
48meningioma10.1CST3
49oligohydramnios10.1ACE
50renal tubular dysgenesis10.1AGTR1, AGT

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to diastolic heart failure

Symptoms for Diastolic Heart Failure

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Drugs & Therapeutics for Diastolic Heart Failure

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Diastolic Heart Failure

Drug clinical trials:

Search ClinicalTrials for Diastolic Heart Failure

Search NIH Clinical Center for Diastolic Heart Failure

Search CenterWatch for Diastolic Heart Failure

Genetic Tests for Diastolic Heart Failure

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Anatomical Context for Diastolic Heart Failure

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34MalaCards
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MalaCards organs/tissues related to Diastolic Heart Failure:

34
Heart, Lung, Brain, Kidney, Endothelial, Testes

Animal Models for Diastolic Heart Failure or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Diastolic Heart Failure:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6MYBPC3, ACE, MAPK8, AGT, NOS3
2MP:00020068.0MMP9, MMP2, MMP1, MAPK8, CST3, ACE
3MP:00053677.8MAPK8, AGT, NOS3, CYBB, MMP9, ACE
4MP:00053897.5NOS3, MAPK8, BMP6, ACE, AGT, MMP9
5MP:00036317.4AGT, CYBB, MMP9, MAPK8, MADD, CST3
6MP:00053977.3CYBB, MMP9, MMP2, ACE, MAPK8, NOS3
7MP:00053867.1CYBB, AGT, NOS3, MADD, MAPK8, ACE
8MP:00053876.6MMP9, MMP1, ACE, MAPK8, AGTR1, TTN
9MP:00107686.6TTN, AGT, NOS3, MADD, MAPK8, ACE
10MP:00053696.4CYBB, ANKRD1, AGT, NPPB, TTN, NPPA
11MP:00053786.0CYBB, AGTR1, AGT, NOS3, MAPK8, BMP6
12MP:00053856.0MAPK8, ACE, MMP2, MMP9, MYBPC3, NPPB
13MP:00053765.8MMP9, MMP2, ACE, CST3, NOS3, AGTR1

Publications for Diastolic Heart Failure

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53PubMed
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Articles related to Diastolic Heart Failure:

(show top 50)    (show all 405)
idTitleAuthorsYear
1
Spironolactone made no difference to patients with mild diastolic heart failure. (23447350)
2013
2
Defining diastolic heart failure and identifying effective therapies. (23443447)
2013
3
Energy transfer from systole to diastole: a novel device-based approach for the treatment of diastolic heart failure. (22142202)
2011
4
Adaptive servoventilation in diastolic heart failure and Cheyne-Stokes respiration. (20032021)
2010
5
Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure. (19850745)
2010
6
Usefulness of left atrial volume for the diagnosis of diastolic heart failure: an echocardiographic-catheterization study. (19297043)
2010
7
Office management of patients with diastolic heart failure. (19255076)
2009
8
Hypertension and diastolic heart failure. (19863866)
2009
9
Current perspectives on cardiac function in patients with diastolic heart failure. (19255354)
2009
10
Novel strategies for the detection of systolic and diastolic heart failure. (20436851)
2009
11
Effects of fixed-dose isosorbide dinitrate/hydralazine on diastolic function and exercise capacity in hypertension-induced diastolic heart failure. (19620510)
2009
12
An unusual case of hypertensive diastolic heart failure with bilateral subclavian artery stenosis. (19214295)
2009
13
Diabetes and prognosis: are systolic and diastolic heart failure different? (19033294)
2009
14
Hemodynamic characteristics of patients with diastolic heart failure and hypertension. (18971551)
2008
15
Optimal noninvasive assessment of diastolic heart failure in patients with atrial fibrillation: comparison of tissue doppler echocardiography, left atrium size, and brain natriuretic peptide. (17904810)
2008
16
Focale: study of systolic and diastolic heart failure in a French elderly population. (17399824)
2008
17
Renin-angiotensin system gene polymorphisms and diastolic heart failure. (19021695)
2008
18
The effects of maximal treadmill graded exercise testing on haemorheological, haemodynamic and flow cytometry platelet markers in patients with systolic or diastolic heart failure. (18257777)
2008
19
Digoxin and reduction of heart failure hospitalization in chronic systolic and diastolic heart failure. (19064024)
2008
20
Treating diastolic heart failure. (18625789)
2008
21
Elevation of the ratio of transmitral E velocity to early diastolic mitral annular velocity continues even after recovery from acute stage in patients with diastolic heart failure. (19027604)
2008
22
Left ventricular geometry and renal function in hypertensive patients with diastolic heart failure. (17261425)
2007
23
How to diagnose diastolic heart failure a consensus statement. (17890729)
2007
24
How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. (17428822)
2007
25
Physical function and quality of life in older women with diastolic heart failure: effects of a progressive walking program on sleep patterns. (17541316)
2007
26
Ventriculovascular coupling in systolic and diastolic heart failure. (17543251)
2006
27
Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy. (16214409)
2006
28
Force- and relaxation-frequency relations in patients with diastolic heart failure. (17070168)
2006
29
Clinical advances in diastolic heart failure. (17167382)
2006
30
Diastolic heart failure in the elderly and the potential role of aldosterone antagonists. (16732689)
2006
31
Diastolic heart failure: perception of the syndrome and scope of the problem. (17084176)
2006
32
Treating diastolic heart failure with AGE crosslink breakers: thinking outside the heart failure box. (15812747)
2005
33
ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure. (15662228)
2005
34
Diagnostic criteria for diastolic heart failure. (16003646)
2005
35
Diastolic dysfunction and diastolic heart failure: mechanisms and epidemiology. (15865857)
2005
36
Ventriculovascular coupling in systolic and diastolic heart failure. (16332314)
2005
37
Diastolic heart failure. (15659738)
2005
38
Epidemiology of diastolic heart failure. (16003647)
2005
39
Heart rate variability and diastolic heart failure. (15009853)
2004
40
Elevation of plasma brain natriuretic peptide is a hallmark of diastolic heart failure independent of ventricular hypertrophy. (14715184)
2004
41
Management of diastolic heart failure in older adults: B-type natriuretic peptide was not mentioned. (15178632)
2004
42
Diastolic heart failure. (14630731)
2003
43
Prevention of diastolic heart failure by endothelin type A receptor antagonist through inhibition of ventricular structural remodeling in hypertensive heart. (11910313)
2002
44
Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction. (11889013)
2002
45
Defining diastolic heart failure. (11294819)
2001
46
Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure? (11502702)
2001
47
Diastolic heart failure: identification and characterization. Is there a role for invasive methods? (10582454)
1999
48
Treating diastolic heart failure: the role of calcium antagonists. (10582472)
1999
49
Diastolic heart failure: identification and characterization. Doppler echocardiography: the "old" approach. (10582451)
1999
50
Mechanisms, diagnosis, and treatment of diastolic heart failure. (7611107)
1995

Variations for Diastolic Heart Failure

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Expression for genes affiliated with Diastolic Heart Failure

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for genes affiliated with Diastolic Heart Failure

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 5Cell Signaling Technology, 31KEGG, 55R&D Systems, 61Thomson Reuters, 52PharmGKB, 13EMD Millipore
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Pathways related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9NPPB, NPPA
29.7MMP1, MMP2
39.7AGT, MAPK8
49.6MMP1, MMP9
5
Show member pathways
Angiogenesis39
9.5NOS3, MMP9
69.4CYBB, MMP9, MMP2
79.4CYBB, NOS3, NPPA
8
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.3TTN, MYBPC3, ACE
99.3MMP9, MMP2, ACE
109.2MMP9, MMP2, MMP1
11
Show member pathways
9.2MMP1, MMP2, MMP9
12
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.2MMP9, MAPK8, MADD
13
Show member pathways
9.1ACE, NOS3, AGT, AGTR1
149.1MAPK8, NPPA, NPPB, AGT
159.1MMP9, MMP2, NOS3
169.1NOS3, MMP2, MMP9
179.1MMP9, MMP2, MAPK8
189.1MAPK8, MMP2, MMP9
199.0CST3, ACE, MMP2, MMP9
20
Show member pathways
8.9CST3, MMP1, MMP2, MMP9
21
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.8AGTR1, NOS3, MAPK8, MMP2
228.7NOS3, MMP1, MMP2, MMP9
238.7MAPK8, MMP1, MMP2, MMP9
248.6MMP9, MMP2, MAPK8, NOS3
25
Show member pathways
8.5CYBB, MMP9, MMP2, MMP1, MAPK8
26
Show member pathways
Cytoskeleton remodeling FAK signaling61
Development Endothelin 1 EDNRA transactivation of EGFR61
8.3MMP9, MMP2, MAPK8, NOS3, NPPB
27
Show member pathways
8.3ACE, BMP6, MAPK8, AGT, AGTR1
28
Show member pathways
7.4MMP9, MMP2, MMP1, BMP6, MAPK8, NOS3

Compounds for genes affiliated with Diastolic Heart Failure

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 252)
idCompoundScoreTop Affiliating Genes
1trandolapril46 1210.7NPPA, ACE, NPPB, AGTR1
2benazepril46 52 1211.6AGT, AGTR1, NPPA, ACE
3enalaprilat469.5AGT, NPPB, ACE, NPPA
4valsartan46 62 30 1212.5ACE, AGTR1, AGT, NPPB
5lisinopril46 52 25 1212.5AGTR1, AGT, NPPB, NPPA, ACE
6ramipril46 1210.4ACE, NPPB, NPPA, AGTR1, CST3
7atenolol46 52 30 25 1213.4AGTR1, AGT, MMP2, NPPB, ACE
8digoxin46 62 52 25 1213.3NPPA, AGTR1, CST3, NPPB, ACE
9chymostatin469.3ACE, MMP9, AGTR1, AGT
10fosinopril46 1210.3AGTR1, NPPA, ACE, MMP9, NPPB
11metoprolol46 52 30 25 1213.3NPPA, NOS3, NPPB, ACE
12carvedilol46 52 30 1212.2AGTR1, NPPB, NPPA, NOS3, ACE
13nitroglycerin46 1210.1ACE, NOS3, NPPA, NPPB, AGTR1
14telmisartan46 30 1211.1NPPB, AGT, AGTR1, ACE
15perindopril46 52 1211.0NPPB, AGT, AGTR1, NOS3, ACE, NPPA
16amlodipine46 52 25 1212.0AGT, NPPB, NPPA, NOS3, ACE, AGTR1
17phenylephrine46 30 25 1211.8NPPA, AGTR1, MMP2, AGT, NOS3, NPPB
18l-nmma468.8MMP9, NOS3, NPPA, NPPB, AGT, AGTR1
19aprotinin46 129.8AGT, NPPB, MMP9, MMP2, MMP1, CST3
20captopril46 62 52 30 1212.8MMP2, CST3, ACE, NPPA, NPPB, AGT
218-isoprostane468.8CYBB, NPPB, NOS3, MMP2, MMP9, AGTR1
22pravastatin46 52 30 25 1212.7MMP1, MMP2, ACE, NOS3, NPPB, AGTR1
23fluvastatin46 52 30 1211.7AGTR1, NOS3, MMP1, MMP9, ACE
24enalapril46 52 1210.7AGT, BMP6, ACE, AGTR1, NPPB, NPPA
25rosiglitazone30 46 52 25 1212.5NPPB, MMP9, MMP2, MMP1, NOS3, AGTR1
26candesartan46 52 30 1211.5MMP2, AGTR1, AGT, NPPB, NOS3, ACE
27ang ii468.5NPPB, NPPA, NOS3, MAPK8, ACE, AGTR1
28nifedipine46 30 52 1211.3AGTR1, MMP9, AGT, NPPA, BMP6, ACE
29losartan46 52 30 1211.3NPPB, AGTR1, AGT, NPPA, BMP6, MMP1
30n acetylcysteine468.2CST3, MMP9, MMP1, MAPK8, AGT, AGTR1
31procollagen468.2NPPB, BMP6, MMP1, MMP2, MMP9
32prostacyclin468.1AGTR1, AGT, ACE, BMP6, NOS3, NPPB
33arginine468.1MYBPC3, CST3, NOS3, AGT, AGTR1, CYBB
34aspirin46 52 30 2510.9MMP2, ACE, BMP6, NOS3, NPPB, AGTR1
35genistein46 30 62 3 25 1212.8AGT, MMP2, MMP9, NOS3, NPPB, AGTR1
36cyclosporin a46 30 629.8NPPA, CST3, NPPB, BMP6, MMP1, AGT
37epinephrine46 25 129.7MMP2, MMP9, NPPA, MMP1, BMP6, NPPB
38acetylcholine46 52 30 25 1211.7ACE, TTN, NOS3, NPPB, BMP6, AGT
39atorvastatin46 52 30 25 1211.5MMP9, MMP2, MMP1, ACE, BMP6, NOS3
40methotrexate52 46 129.5MMP2, MMP9, MMP1, NOS3, CST3, BMP6
41norepinephrine46 25 129.4ACE, MMP1, MMP2, MMP9, AGTR1, BMP6
42pge2467.4NPPB, MMP9, MMP2, MMP1, MAPK8, AGT
43dexamethasone46 52 30 1210.3MMP9, CYBB, BMP6, MMP1, MAPK8, CST3
44pd 98,059467.3MAPK8, MMP1, MMP2, MMP9, AGT, NOS3
45h2o2467.3MAPK8, CYBB, MMP1, NOS3, AGT, AGTR1
46sb 20358046 628.0MMP9, AGTR1, BMP6, MAPK8, NOS3, NPPB
47creatinine466.5TTN, MMP9, MMP2, MMP1, ACE, BMP6
48calcium46 52 25 129.5NOS3, AGTR1, AGT, CST3, NPPB, NPPA
49vegf466.2AGTR1, CYBB, MMP9, MMP2, MMP1, BMP6
50serine465.8AGTR1, AGT, NPPB, NOS3, CST3, BMP6

GO Terms for genes affiliated with Diastolic Heart Failure

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17Gene Ontology
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Cellular components related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1I bandGO:0316749.6ANKRD1, TTN
2extracellular regionGO:0055767.0AGT, TTN, MMP9, MMP2, MMP1, ACE
3extracellular spaceGO:0056157.0MMP9, MMP2, ACE, BMP6, CST3, NPPA

Biological processes related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
3renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, AGT
4regulation of renal sodium excretionGO:03581310.3AGTR1, AGT
5positive regulation of cholesterol esterificationGO:01087310.2AGT, AGTR1
6regulation of renal output by angiotensinGO:00201910.2ACE, AGT
7regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.2ACE, AGTR1
8low-density lipoprotein particle remodelingGO:03437410.2AGTR1, AGT
9cGMP biosynthetic processGO:00618210.2NPPA, NPPB
10receptor guanylyl cyclase signaling pathwayGO:00716810.2NPPB, NPPA
11positive regulation of cellular protein metabolic processGO:03227010.2AGT, AGTR1
12positive regulation of renal sodium excretionGO:03581510.1NPPB, AGT
13regulation of vasodilationGO:04231210.1ACE, NPPB, AGTR1
14angiotensin maturationGO:00200310.0ACE, AGT
15regulation of vasoconstrictionGO:01922910.0ACE, AGT, AGTR1
16positive regulation of macrophage derived foam cell differentiationGO:01074410.0AGT, AGTR1
17cardiac muscle tissue morphogenesisGO:0550089.9ANKRD1, TTN
18sarcomere organizationGO:0452149.8ANKRD1, MYBPC3, TTN
19regulation of blood vessel sizeGO:0508809.8NPPB, NPPA, NOS3
20blood vessel remodelingGO:0019749.7AGT, NOS3, ACE
21negative regulation of cell growthGO:0303089.7AGT, NPPB, NPPA
22nitric oxide mediated signal transductionGO:0072639.6AGT, NOS3
23collagen catabolic processGO:0305749.5MMP1, MMP2, MMP9
24regulation of blood pressureGO:0082179.4ACE, NOS3, NPPA, NPPB
25extracellular matrix disassemblyGO:0226179.4MMP1, MMP2, MMP9
26extracellular matrix organizationGO:0301989.2AGT, MMP1, MMP2, MMP9
27kidney developmentGO:0018229.2AGTR1, AGT, BMP6, ACE
28positive regulation of protein secretionGO:0507149.1BMP6, ANKRD1
29cellular protein metabolic processGO:0442679.1AGT, ACE, MMP1, MMP2
30cellular response to mechanical stimulusGO:0712608.7AGT, NPPA, MAPK8, BMP6, ANKRD1

Molecular functions related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1titin bindingGO:03143210.0ANKRD1, MYBPC3
2bradykinin receptor bindingGO:0317119.9AGTR1, ACE
3hormone activityGO:0051799.5NPPA, NPPB, AGT
4metalloendopeptidase activityGO:0042228.9MMP1, MMP2, MMP9
5protein bindingGO:0055156.1AGTR1, CYBB, TTN, MMP9, MMP2, ANKRD1

Products for genes affiliated with Diastolic Heart Failure

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Sources for Diastolic Heart Failure

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet