MCID: DST006
MIFTS: 50

Diastolic Heart Failure malady

Summaries for Diastolic Heart Failure

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Diastolic heart failure and diastolic dysfunction refer to the decline in performance of one (usually... more...

MalaCards: Diastolic Heart Failure, also known as heart failure, diastolic, is related to amyloidosis and hypertensive heart disease. An important gene associated with Diastolic Heart Failure is ANKRD1 (ankyrin repeat domain 1 (cardiac muscle)), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The compounds captopril and rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Diastolic Heart Failure

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT
See all sources

Aliases & Descriptions:

diastolic heart failure 8 10
heart failure, diastolic 61


External Ids:

Disease Ontology8 DOID:9775
MeSH35 D054144
SNOMED-CT57 418304008
ICD9CM27 428.30, 428.3

Related Diseases for Diastolic Heart Failure

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diastolic Heart Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.5NPPB, CST3
2hypertensive heart disease30.5NPPB, NPPA, AGTR1, MMP1, ACE
3hypertrophic cardiomyopathy30.4MYBPC3
4coronary heart disease30.4CST3, NPPB, AGTR1, AGT, NOS3, ACE
5coronary artery disease,30.4CST3, ACE, NOS3, MMP9, CYBB, AGT
6familial hypertrophic cardiomyopathy30.2MYBPC3
7insulin resistance30.2ACE, NOS3, MAPK8, AGT, AGTR1
8vascular disease30.2CST3, BMP6, AGTR1, AGT, CYBB, MMP9
9atherosclerosis30.1CST3, BMP6, AGTR1, AGT, MAPK8, CYBB
10systolic heart failure11.0
11hypertension, diastolic10.7
12acute myocarditis10.3
13peripheral vascular disease10.1
14cardiac tamponade10.1
15mixed connective tissue disease10.1
16systemic lupus erythematosus10.1
17heart lymphoma10.1
18peripartum cardiomyopathy10.1
19constrictive pericarditis10.1
20sleep disorder10.1
21baroreflex failure10.1
22heart tumor10.1
23left ventricular outflow tract obstruction10.1
24sleep apnea10.1
25adiponectin deficiency10.1
26pulmonary function10.1
27myocarditis10.0NPPB
28mitral valve prolapse10.0AGTR1
29central sleep apnea10.0NPPB
30pulmonary embolism10.0NPPB
31nephritis10.0ACE
32mitral valve disease10.0NPPA
33oligohydramnios10.0ACE
34anuria10.0ACE
35ureteral obstruction10.0AGTR1
36gitelman syndrome10.0AGT
37glaucoma10.0MMP1
38sick sinus syndrome10.0NPPA
39hepatorenal syndrome10.0NPPA
40hepatopulmonary syndrome10.0NOS3
41chagas disease10.0NPPB
42sickle cell disease10.0NOS3
43synovitis10.0MMP1
44portal hypertension10.0NOS3
45thromboembolism10.0NOS3
46intracranial aneurysm10.0NOS3
47cerebral amyloid angiopathy10.0CST3
48pulmonary disease, chronic obstructive10.0MMP9
49periodontitis10.0MMP9
50asthma10.0MMP9

Graphical network of the top 20 diseases related to Diastolic Heart Failure:



Diseases related to diastolic heart failure

Clinical Features for Diastolic Heart Failure

Drugs & Therapeutics for Diastolic Heart Failure

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diastolic Heart Failure

Drug clinical trials:

Search ClinicalTrials for Diastolic Heart Failure

Search NIH Clinical Center for Diastolic Heart Failure

Search CenterWatch for Diastolic Heart Failure

Genetic Tests for Diastolic Heart Failure

Anatomical Context for Diastolic Heart Failure

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Diastolic Heart Failure:

33
Brain, Heart, Kidney, Lung, T cells, B cells, Endothelial, Cardiac myocytes

Animal Models for Diastolic Heart Failure or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Diastolic Heart Failure

Sources:
51PubMed
See all sources

Articles related to Diastolic Heart Failure:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF). (22983988)
2013
2
Effects of Auto-Servo Ventilation on Patients with Sleep-Disordered Breathing, Stable Systolic Heart Failure and Concomitant Diastolic Dysfunction: Subanalysis of a Randomized Controlled Trial. (24029470)
2013
3
The association and predictive value analysis of metabolic syndrome on diastolic heart failure in patients at high risk for coronary artery disease. (23800086)
2013
4
Diastolic dysfunction and abnormal exercise ventilation predict adverse outcome in elderly patients with chronic systolic heart failure. (21450576)
2012
5
Diabetic cardiomyopathy and diastolic heart failure -- difficulties with relaxation. (22502812)
2012
6
Diastolic heart failure in dialysis patients: mechanisms, diagnostic approach, and treatment. (22273530)
2012
7
Pathophysiology of systolic and diastolic heart failure. (22980053)
2012
8
Energy transfer from systole to diastole: a novel device-based approach for the treatment of diastolic heart failure. (22142202)
2011
9
PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. (21036891)
2011
10
Differences in sarcoplasmic reticulum Ca2+ leak characteristics between systolic and diastolic heart failure rabbit models. (21789895)
2011
11
Myocardial performance (Tei) index is normal in diastolic and systolic heart failure induced by pressure overload in rats. (20562113)
2010
12
Office management of patients with diastolic heart failure. (19255076)
2009
13
Diabetes and prognosis: are systolic and diastolic heart failure different? (19033294)
2009
14
Mortality in diastolic heart failure: an update. (19367145)
2009
15
Prediction clinical profile to distinguish between systolic and diastolic heart failure in hospitalized patients. (19393500)
2009
16
Characteristics of myocardial deformation and rotation in subjects with diastolic dysfunction without diastolic heart failure. (20049139)
2009
17
Chronic systemic inflammation accompanies impaired ventricular diastolic function, detected by Doppler imaging, in patients with newly diagnosed systolic heart failure (Hellenic Heart Failure Study). (19165564)
2009
18
Optimal treatment of hypertension with diastolic heart failure. (18313629)
2008
19
Influence of prosthesis-patient mismatch on diastolic heart failure after aortic valve replacement. (18355517)
2008
20
Heart failure with a normal left ventricular ejection fraction: diastolic heart failure. (18596852)
2008
21
Difference of clinical characteristics between hypertensive patients with and without diastolic heart failure: the roles of diastolic dysfunction and renal insufficiency. (19015593)
2008
22
Classifying systolic and diastolic heart failure. (17356024)
2007
23
Contribution of right-sided heart enlargement to cardiomegaly on chest roentgenogram in diastolic and systolic heart failure. (17196464)
2007
24
Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. (17283265)
2007
25
Brain natriuretic peptide plasma level is a reliable indicator of advanced diastolic dysfunction in patients with chronic heart failure. (16476572)
2007
26
Statins and diastolic heart failure. (16740328)
2007
27
Role of xanthine oxidoreductase in the reversal of diastolic heart failure by candesartan in the salt-sensitive hypertensive rat. (17709654)
2007
28
Systolic and diastolic heart failure: different phenotypes of the same disease? (16884955)
2007
29
Systolic and diastolic heart failure: differences and similarities. (17826648)
2007
30
Disruption of caveolin-1 leads to enhanced nitrosative stress and severe systolic and diastolic heart failure. (16380094)
2006
31
ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure. (15662228)
2005
32
Diastolic heart failure: a review and primary care perspective. (15879566)
2005
33
Therapy for diastolic heart failure. (16115517)
2005
34
Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure; Japanese Diastolic Heart Failure Study (J-DHF). (16198251)
2005
35
Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure. (15604330)
2005
36
Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure. (15851588)
2005
37
Left ventricular diastolic dysfunction and diastolic heart failure. (14746527)
2004
38
Diastolic heart failure. (15359430)
2004
39
Heart failure with preserved ejection fraction: is this diastolic heart failure? (12742292)
2003
40
Diastolic heart failure: can we afford to be in diastole? (16352119)
2003
41
Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction. (11889013)
2002
42
Primary diastolic heart failure. (11986532)
2002
43
Therapy for diastolic heart failure: on the road from myths to multicenter trials. (11561222)
2001
44
Systolic versus diastolic heart failure in community practice: clinical features, outcomes, and the use of angiotensin-converting enzyme inhibitors. (11099679)
2000
45
Diastolic heart failure: diagnosis and treatment. (11205721)
2000
46
Relation of atrial natriuretic peptides to left ventricular systolic and diastolic function in heart failure. (10937980)
1999
47
Diastolic heart failure: identification and characterization. The role of radionuclide ventriculography. (10582453)
1999
48
Diastolic ventricular interaction in chronic heart failure: relation to heart rate variability and neurohumoral status. (10651169)
1998
49
An infant with hypereosinophilic syndrome and heart failure markedly responded to prednisolone: serial changes of left ventricular wall thickening and left ventricular diastolic dysfunction observed by echocardiography. (10651172)
1998
50
Effects of atrial natriuretic peptide on myocardial contractile and diastolic function in patients with heart failure. (1535081)
1992

Genetic Variations for Diastolic Heart Failure

Expression for genes affiliated with Diastolic Heart Failure

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diastolic Heart Failure

Search GEO for disease gene expression data for Diastolic Heart Failure.

Pathways for genes affiliated with Diastolic Heart Failure

Sources:
50PharmGKB, 38NCBI BioSystems Database, 53R&D Systems, 52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 54Reactome, 30KEGG
See all sources

Pathways related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2NOS3
29.6AGT, MAPK8
39.5ACE, MMP9, MMP2
4
Hide members
9.5MMP2, MMP1, MMP9
59.4NOS3, MMP9, MMP2
69.4MMP2, MMP9, NOS3
79.2ACE, MMP9, MMP2, CST3
8
Cell adhesion ECM remodeling
Hide members
9.2CST3, MMP2, MMP1, MMP9
99.1MMP9, MMP2, MAPK8
109.1MMP2, MMP1, MMP9, NOS3
11
Hide members
9.1AGTR1, AGT, MAPK8, NOS3
12
Hide members
9.0MMP9, MMP1, MMP2, LOXL3
13
Development PDGF signaling via STATs and NF-kB
Hide members
9.0NOS3, MMP2, MAPK8, AGTR1
148.8NOS3, MMP9, MMP2, MAPK8
15
Development Endothelin-1/EDNRA signaling
Hide members
8.6NPPB, MAPK8, MMP2, MMP9, NOS3
16
Hide members
8.6MMP9, MMP1, MMP2, CYBB, MAPK8
17
Hide members
8.3BMP6, AGTR1, AGT, MAPK8, ACE
18
Hide members
7.7BMP6, MAPK8, MMP2, MMP1, MMP9, NOS3

Compounds for genes affiliated with Diastolic Heart Failure

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 207)
idCompoundScoreTop Affiliating Genes
1captopril45 29 50 60 1114.3MMP2, CST3
2rosiglitazone45 50 29 11 2414.3MMP1, NPPB
3losartan45 50 29 1113.2AGT, NPPA, NPPB
4procollagen4510.2NPPB
5pge24510.1MMP9, MMP2
6cyclosporin a45 29 6012.1MMP1, NPPB, CST3
7aprotinin45 1111.0MMP1, MMP2, NPPB
8epinephrine45 11 2412.0AGT, AGTR1, NPPA, NPPB
9trandolapril45 1110.9ACE, AGTR1, NPPA, NPPB
10benazepril45 1110.9NPPA, ACE, AGT, AGTR1
11enalaprilat459.8AGT, ACE, NPPB, NPPA
12norepinephrine45 11 2411.8MMP1, BMP6
13valsartan45 60 29 1112.7NPPB, AGTR1, AGT, ACE
14lisinopril45 11 2411.7NPPB, AGTR1, AGT, ACE, NPPA
15ramipril45 1110.7AGTR1, CST3, NPPB, NPPA, ACE
16metoprolol45 29 50 11 2413.7NPPA, NOS3, ACE, NPPB
17chymostatin459.6MMP9, ACE, AGT, AGTR1
18telmisartan45 29 1111.6NPPB, AGT, AGTR1, ACE
19fosinopril45 1110.6AGTR1, NPPA, MMP9, NPPB, ACE
20digoxin45 50 60 11 2413.6NPPB, CST3, NPPA, ACE, AGTR1
21atenolol45 29 50 11 2413.6AGTR1, ACE, MMP2, AGT, NPPB
22carvedilol45 50 29 1112.6NOS3, NPPB, NPPA, ACE, AGTR1
23cgs-27023a459.6MMP1, MMP9, MMP2
24nitroglycerin45 1110.6NPPB, ACE, NOS3, AGTR1, NPPA
25irbesartan45 29 50 1112.4AGTR1, ACE, MMP9, AGT
26perindopril45 50 1111.4NPPA, ACE, AGT, NOS3, NPPB, AGTR1
27amlodipine45 50 11 2412.4NPPB, ACE, AGTR1, AGT, NPPA, NOS3
28l-nmma459.3NPPB, AGT, NOS3, NPPA, MMP9, AGTR1
29geranylgeranyl pyrophosphate459.3AGT, MMP1, MMP9, NOS3
30phenylephrine45 29 11 2412.3AGTR1, AGT, MMP2, NPPA, NPPB, NOS3
318-isoprostane459.2NPPB, AGTR1, CYBB, NOS3, MMP9, MMP2
32haloperidol45 29 2 50 1113.1NPPA, AGTR1, NPPB, PVALB, MMP1, AGT
33candesartan45 29 1111.0NPPB, AGTR1, AGT, MMP2, MMP1, NOS3
34enalapril45 50 1110.9AGT, NPPB, NPPA, BMP6, AGTR1, ACE
35ang ii458.8NOS3, AGT, AGTR1, NPPA, ACE, NPPB
36nifedipine45 50 29 1111.6BMP6, ACE, MMP9, AGT, AGTR1, NPPA
37prostacyclin458.5NPPB, ACE, NOS3, AGT, AGTR1, BMP6
38n acetylcysteine458.4MMP1, MAPK8, AGT, MMP2, AGTR1, CST3
39aspirin45 50 29 2411.4MMP2, AGTR1, NOS3, NPPB, ACE, MMP1
40dexamethasone45 50 29 1111.3MMP9, CYBB, MAPK8, AGT, BMP6, NPPB
41atorvastatin45 50 29 11 2412.3MMP9, NPPB, MMP2, MMP1, NOS3, BMP6
42genistein45 29 60 2 11 2413.2MMP2, MMP9, MMP1, MAPK8, AGT, AGTR1
43acetylcholine45 50 29 11 2412.1AGTR1, NPPB, NOS3, PVALB, AGT, ACE
44serine458.0AGT, AGTR1, MMP9, MMP1, MMP2, CYBB
45nitric oxide45 11 249.6NOS3, ACE, CYBB, AGT, PVALB, NPPB
46pd 98,059457.6BMP6, MMP9, MMP1, AGT, MAPK8, MMP2
47creatinine457.6AGTR1, AGT, MMP2, MMP1, MMP9, ACE
48sb 20358045 608.5MMP1, NPPB, BMP6, AGTR1, AGT, MMP2
49h2o2457.1NOS3, AGTR1, MMP1, BMP6, MAPK8, CYBB
50vegf456.7NPPB, MAPK8, MMP2, CYBB, MMP9, AGT

GO Terms for genes affiliated with Diastolic Heart Failure

Sources:
16Gene Ontology
See all sources

Cellular components related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8CST3, NPPB, NPPA, AGT, MMP2, MMP1
2extracellular spaceGO:0056157.0ACE, LOXL3, CST3, NPPB, NPPA, BMP6

Biological processes related to Diastolic Heart Failure according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.3AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.3AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.3AGTR1, AGT
4renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, AGT
5regulation of renal output by angiotensinGO:00201910.3ACE, AGT
6regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.2ACE, AGTR1
7positive regulation of cholesterol esterificationGO:01087310.2AGTR1, AGT
8regulation of vasodilationGO:04231210.2ACE, AGTR1, NPPB
9cGMP biosynthetic processGO:00618210.1NPPA, NPPB
10regulation of vasoconstrictionGO:01922910.1ACE, AGT, AGTR1
11receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPA, NPPB
12low-density lipoprotein particle remodelingGO:03437410.0AGT, AGTR1
13positive regulation of cellular protein metabolic processGO:03227010.0AGT, AGTR1
14regulation of blood vessel sizeGO:05088010.0NPPB, NPPA, NOS3
15blood vessel remodelingGO:0019749.9AGT, NOS3, ACE
16regulation of blood pressureGO:0082179.8ACE, NOS3, NPPA, NPPB
17angiotensin maturationGO:0020039.7ACE, AGT
18cellular response to mechanical stimulusGO:0712609.7MAPK8, ANKRD1, AGT
19collagen catabolic processGO:0305749.6MMP9, MMP1, MMP2
20extracellular matrix disassemblyGO:0226179.6MMP2, MMP1, MMP9
21kidney developmentGO:0018229.3BMP6, AGTR1, AGT, ACE
22extracellular matrix organizationGO:0301989.1AGT, MMP2, MMP1, MMP9

Molecular functions related to Diastolic Heart Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1titin bindingGO:03143210.1MYBPC3, ANKRD1
2acetyltransferase activator activityGO:01069810.0AGT, AGTR1
3bradykinin receptor bindingGO:0317119.9ACE, AGTR1
4hormone activityGO:0051799.5AGT, NPPA, NPPB

Products for genes affiliated with Diastolic Heart Failure

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diastolic Heart Failure

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet