MCID: DFF012
MIFTS: 42

Differentiating Neuroblastoma malady

Neuronal diseases category

Summaries for Differentiating Neuroblastoma

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32MalaCards
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MalaCards: Differentiating Neuroblastoma is related to neuroblastoma and pheochromocytoma. An important gene associated with Differentiating Neuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways are Orexin and neuropeptides FF and QRFP bind to their respective receptors and Ca-dependent events. The compounds catecholamine and isoflurane have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and brain, and related mouse phenotypes are behavior/neurological and nervous system.

Aliases & Classifications for Differentiating Neuroblastoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

differentiating neuroblastoma 8 10 60


External Ids:

Disease Ontology8 DOID:4160
NCIt39 C42048

Related Diseases for Differentiating Neuroblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Differentiating Neuroblastoma:



Diseases related to differentiating neuroblastoma

Clinical Features for Differentiating Neuroblastoma

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Drugs & Therapeutics for Differentiating Neuroblastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Differentiating Neuroblastoma

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Genetic Tests for Differentiating Neuroblastoma

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Anatomical Context for Differentiating Neuroblastoma

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32MalaCards
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MalaCards organs/tissues related to Differentiating Neuroblastoma:

32
Bone, Bone marrow, Brain, Testes, Skeletal muscle, Monocytes, B cells, Pituitary, Adrenal gland

Animal Models for Differentiating Neuroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.4PDYN, NTRK1, POU4F2, MYCN, HCRT, HCRTR1
2MP:000363110.1ASCL1, CACNA1B, PDYN, NTRK1, POU4F2, MAP3K10

Publications for Differentiating Neuroblastoma

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50PubMed
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Articles related to Differentiating Neuroblastoma:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Effect of I^-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells. (23900747)
2013
2
Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma. (24335960)
2013
3
Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. (22911660)
2013
4
Time course study of AI^ formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: protective role of autophagy. (23726866)
2013
5
HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. (21507931)
2011
6
Diffusion-weighted MRI for differentiation of neuroblastoma and ganglioneuroblastoma/ganglioneuroma. (20462716)
2011
7
Hedgehog signaling pathway in neuroblastoma differentiation. (21129534)
2010
8
Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study. (20459794)
2010
9
Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression. (20144241)
2010
10
Extracellular guanosine and GTP promote expression of differentiation markers and induce S-phase cell-cycle arrest in human SH-SY5Y neuroblastoma cells. (19111604)
2009
11
HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. (19903792)
2009
12
Targeting Id protein interactions by an engineered HLH domain induces human neuroblastoma cell differentiation. (19330020)
2009
13
Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation. (18212744)
2008
14
Differentiating neuroblastoma arising in mediastinal germ cell tumour. (18631196)
2008
15
Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines. (17680992)
2007
16
Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase. (17388787)
2007
17
Cholesterol supports the retinoic acid-induced synaptic vesicle formation in differentiating human SH-SY5Y neuroblastoma cells. (17540009)
2007
18
Staurosporine differentiation of NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells induces selectivity of NPFF activity towards opioid receptors. (17418451)
2007
19
Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors. (15753651)
2005
20
Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma. (15605081)
2005
21
Selenomethionine prevents degeneration induced by overexpression of wild-type human alpha-synuclein during differentiation of neuroblastoma cells. (16373949)
2005
22
Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. (15287901)
2004
23
Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells. (15485494)
2004
24
Neuronal differentiation and TrkA expression of neuroblastoma induced by the combination treatment of interferon-gamma and NGF]. (15144710)
2004
25
Presenilin expression during induced differentiation of the human neuroblastoma SH-SY5Y cell line. (15209417)
2004
26
Negative autoregulation of p73 and p53 by DeltaNp73 in regulating differentiation and survival of human neuroblastoma cells. (12880968)
2003
27
Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: enhancement by combination with interferon-alpha. (11743648)
2002
28
Retinoblastoma family proteins induce differentiation and regulate B-myb expression in neuroblastoma cells. (11464857)
2001
29
Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells. (11668484)
2001
30
Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells. (11754965)
2001
31
A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (10837911)
2000
32
Neuronal differentiation in human neuroblastoma cells by nerve growth factor following TrkA up-regulation by interferon-gamma. (10842245)
2000
33
Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein. (10412034)
1999
34
Differentiation and apoptosis of neuroblastoma cells: role of N-myc gene product. (10088728)
1999
35
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. (10080936)
1999
36
Retinoic acid-induced differentiation in a human neuroblastoma cell line is associated with an increase in nitric oxide synthesis. (9397160)
1998
37
Differential effects of peptide histidine isoleucine (PHI) and related peptides on stimulation and suppression of neuroblastoma cell proliferation. A novel VIP-independent action of PHI via MAP kinase. (9677397)
1998
38
Differential sensitivity of human neuroblastoma cell lines to ethanol: correlations with their proliferative responses to mitogenic growth factors and expression of growth factor receptors. (9347077)
1997
39
Protein kinase C isoforms and growth, differentiation and phosphatidylcholine turnover in human neuroblastoma cells. (8906563)
1996
40
Differentiation agents enhance cholinergic characteristics of LA-N-2 human neuroblastoma cells. (8637428)
1996
41
Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. (18627021)
1996
42
Gene expression and neuroblastoma cell differentiation in response to retinoic acid: differential effects of 9-cis and all-trans retinoic acid. (7576951)
1995
43
Increased retinoic acid receptor gamma expression suppresses the malignant phenotype and alters the differentiation potential of human neuroblastoma cells. (7630632)
1995
44
Using neuroblastoma cell lines to address differential specificity to organophosphates. (7671443)
1995
45
Radiation therapy of well-differentiated neuroblastoma and central neurocytoma. (8339224)
1993
46
Retinoic acid receptor expression during the in vitro differentiation of human neuroblastoma. (8121610)
1993
47
Inducible expression of calcyclin, a gene with strong homology to S-100 protein, during neuroblastoma cell differentiation and its prevalent expression in Schwann-like cell lines. (1998963)
1991
48
Enzymatic activities during differentiation of the human neuroblastoma cells, LA-N-1 and LA-N-2. (2352289)
1990
49
Thymic carcinoma with focal neuroblastoma differentiation. (3592061)
1987
50
Lateral diffusion of membrane D-galactosyl glycoconjugates of differentiating neuroblastoma cells. (7332554)
1981

Genetic Variations for Differentiating Neuroblastoma

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Expression for genes affiliated with Differentiating Neuroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Differentiating Neuroblastoma

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Pathways for genes affiliated with Differentiating Neuroblastoma

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53Reactome, 49PharmGKB
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Pathways related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5HCRTR1, HCRT
2
Hide members
10.5NTRK1, PDYN, CACNA1B

Compounds for genes affiliated with Differentiating Neuroblastoma

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1catecholamine4410.8HCRT, MYCN, NTRK1, PDYN
2isoflurane44 1111.8CACNA1B, HCRT, HCRTR1
3dopamine44 28 11 2413.8ASCL1, CACNA1B, PDYN, PDE3B, NTRK1, MYCN
4potassium44 11 2412.8CACNA1B, PDYN, PDE3B, NTRK1, HCRT, HCRTR1
5acth4410.8PDYN, PDE3B, IGFBP5, HCRT, HCRTR1
6acetylcholine44 49 28 11 2414.8HCRTR1, HCRT, NTRK1, PDYN, CACNA1B
7ceramide4410.7PDE3B, TFPT, NTRK1, IGFBP5
8capsaicin44 2811.7CACNA1B, PDYN, NTRK1
9alanine4410.7CACNA1B, TFPT, NTRK1, IGFBP5, HCRT, HCRTR1
10opiate4410.7HCRT, NTRK1, PDYN
11calcium44 49 11 2413.7CACYBP, CACNA1B, PDYN, PDE3B, NTRK1, IGFBP5
12adenylate4410.6PDYN, PDE3B, NTRK1, HCRT, HCRTR1
13ribonucleic acid4410.6PDYN, IGFBP5, HCRT, HCRTR1
14npff4410.6HCRT, PDYN
15cholesterol44 28 11 2413.5CACNA1B, PDE3B, TFPT, IGFBP5, HCRT
16serine4410.5COIL, PDE3B, TFPT, NTRK1, IGFBP5, MAP3K10
17gtp44 2811.4TGM3, PDE3B, PDYN, CACNA1B
18tyrosine4410.4PDYN, PDE3B, NTRK1, IGFBP5, MYCN, HCRT
19quinpirole44 2811.4CACNA1B, PDYN
20glycosphingolipid4410.2TFPT, NTRK1

GO Terms for genes affiliated with Differentiating Neuroblastoma

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16Gene Ontology
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Biological processes related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:04848510.5ASCL1, NTRK1
2neuropeptide signaling pathwayGO:00721810.4HCRTR1, HCRT, PDYN
3synaptic transmissionGO:00726810.2HCRTR1, HCRT, PDYN, CACNA1B

Molecular functions related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.5ASCL1, MAP3K10

Products for genes affiliated with Differentiating Neuroblastoma

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Sources for Differentiating Neuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet