MCID: DFF012
MIFTS: 35

Differentiating Neuroblastoma malady

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Differentiating Neuroblastoma

Aliases & Descriptions for Differentiating Neuroblastoma:

Name: Differentiating Neuroblastoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4160
NCIt 47 C42048
UMLS 69 C1511934

Summaries for Differentiating Neuroblastoma

MalaCards based summary : Differentiating Neuroblastoma is related to neuroblastoma and urinary tract papillary transitional cell benign neoplasm. An important gene associated with Differentiating Neuroblastoma is ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1), and among its related pathways/superpathways are Development Dopamine D2 receptor transactivation of EGFR and Endometrial cancer. The drugs Isotretinoin and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and pituitary, and related phenotypes are behavior/neurological and cellular

Related Diseases for Differentiating Neuroblastoma

Diseases related to Differentiating Neuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
id Related Disease Score Top Affiliating Genes
1 neuroblastoma 10.4
2 urinary tract papillary transitional cell benign neoplasm 10.0 ASCL1 SRC
3 glioma 9.9
4 childhood brain germinoma 9.7 MYCN SRC
5 neuronitis 9.6
6 pheochromocytoma 9.5
7 central neurocytoma 9.5
8 neuroendocrine tumor 9.5
9 teratoma 9.5
10 merkel cell carcinoma 9.5
11 mature teratoma 9.5
12 adenoma 9.5
13 mediastinitis 9.5
14 hypoglycemia 9.5
15 dysautonomia 9.5
16 hypoxia 9.5
17 hypersensitivity reaction type ii disease 8.7 ASCL1 BCAR1 MAP1B MAPK1 MYCN POU4F2

Graphical network of the top 20 diseases related to Differentiating Neuroblastoma:



Diseases related to Differentiating Neuroblastoma

Symptoms & Phenotypes for Differentiating Neuroblastoma

MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 ASCL1 MAP1B MAPK1 MYCN POU4F2 SRC
2 cellular MP:0005384 9.7 ASCL1 BCAR1 MAP1B MAPK1 MYCN POU4F2
3 nervous system MP:0003631 9.43 ASCL1 MAP1B MAPK1 MYCN POU4F2 SRC
4 vision/eye MP:0005391 9.1 ASCL1 MAP1B MAPK1 MYCN POU4F2 SRC

Drugs & Therapeutics for Differentiating Neuroblastoma

Drugs for Differentiating Neuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
4
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538
5 Dermatologic Agents Phase 3,Phase 2
6 Gastrointestinal Agents Phase 3,Phase 2
7 Anti-Allergic Agents Phase 3
8 Antipruritics Phase 3
9 Histamine Antagonists Phase 3
10 Histamine H1 Antagonists Phase 3
11
Histamine Phosphate Phase 3 51-74-1 65513
12 Neurotransmitter Agents Phase 3
13
Serotonin Phase 3 50-67-9 5202
14 Serotonin Agents Phase 3
15 Serotonin Antagonists Phase 3
16
Busulfan Approved, Investigational Phase 2 55-98-1 2478
17
Cyclosporine Approved, Investigational, Vet_approved Phase 2 79217-60-0, 59865-13-3 5284373 6435893
18
Melphalan Approved Phase 2 148-82-3 4053 460612
19
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
20
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
21
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
22 Alkylating Agents Phase 2
23 Antiemetics Phase 2
24 Antifungal Agents Phase 2
25 Anti-Infective Agents Phase 2
26 Anti-Inflammatory Agents Phase 2
27 Antilymphocyte Serum Phase 2
28 Antineoplastic Agents, Alkylating Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Antirheumatic Agents Phase 2
31 Autonomic Agents Phase 2
32 Calcineurin Inhibitors Phase 2
33 glucocorticoids Phase 2
34 Hormone Antagonists Phase 2
35 Hormones Phase 2
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
37 Immunosuppressive Agents Phase 2
38 Methylprednisolone acetate Phase 2
39 Methylprednisolone Hemisuccinate Phase 2
40 Neuroprotective Agents Phase 2
41 Peripheral Nervous System Agents Phase 2
42 Prednisolone acetate Phase 2
43 Prednisolone hemisuccinate Phase 2
44 Prednisolone phosphate Phase 2
45 Protective Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3
2 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
3 Chemotherapy, Radiation Therapy, and Umbilical Cord Blood Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003661 Phase 2
4 HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors Recruiting NCT00931931 Phase 1
5 Exploring the Possibility to Use Glycosyltransferase as a Prognosis Marker of Neuroblastoma Completed NCT01638572
6 Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer Completed NCT01353300
7 Immunomonitoring of Children With Neuroblastoma Active, not recruiting NCT01295762

Search NIH Clinical Center for Differentiating Neuroblastoma

Genetic Tests for Differentiating Neuroblastoma

Anatomical Context for Differentiating Neuroblastoma

MalaCards organs/tissues related to Differentiating Neuroblastoma:

39
Testes, Brain, Pituitary

Publications for Differentiating Neuroblastoma

Articles related to Differentiating Neuroblastoma:

(show top 50) (show all 67)
id Title Authors Year
1
Distinct effect of CacyBP/SIP on the ERK1/2-CREB-BDNF pathway in undifferentiated and differentiated neuroblastoma NB2a cells. ( 27180052 )
2016
2
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells. ( 25288153 )
2015
3
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. ( 21559466 )
2011
4
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells. ( 19735367 )
2009
5
BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress. ( 19050044 )
2009
6
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. ( 19223552 )
2009
7
Isoflurane attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in differentiated neuroblastoma SH-SY5Y cells. ( 19032555 )
2009
8
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. ( 19318809 )
2009
9
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. ( 19726241 )
2009
10
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. ( 19647006 )
2009
11
Differentiating neuroblastoma arising in mediastinal germ cell tumour. ( 18631196 )
2008
12
Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells. ( 17293044 )
2007
13
p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma. ( 17912039 )
2007
14
A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. ( 17045782 )
2007
15
Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line. ( 17559250 )
2007
16
Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. ( 17490655 )
2007
17
Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. ( 16407271 )
2006
18
The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells. ( 17050705 )
2006
19
Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. ( 15548427 )
2004
20
Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells. ( 15079871 )
2004
21
Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells. ( 13130517 )
2003
22
Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells. ( 14515147 )
2003
23
Arachidonate release and c-fos expression in various models of hypoxia and hypoxia-hypoglycemia in retinoic acid differentiated neuroblastoma cells. ( 11741009 )
2002
24
Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. ( 11738505 )
2001
25
A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells. ( 11281640 )
2001
26
Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. ( 11606272 )
2001
27
A mathematical model for assessing changes in neurofilament protein levels in neurites and cell bodies of differentiating neuroblastoma cells. ( 10873435 )
2000
28
Relative sensitivity of undifferentiated and cyclic adenosine 3',5'-monophosphate-induced differentiated neuroblastoma cells to cyclosporin A: potential role of beta-amyloid and ubiquitin in neurotoxicity. ( 10718363 )
2000
29
Nicardipine inhibits N-type calcium channels in dbcAMP-differentiated neuroblastoma x glioma hybrid cells (NG 108-15 cells). ( 10437156 )
1999
30
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. ( 10080936 )
1999
31
Binding of dihydroartemisinin to differentiating neuroblastoma cells and rat cortical homogenate. ( 9621346 )
1998
32
Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. ( 9442079 )
1998
33
Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid. ( 9557945 )
1998
34
Nimodipine and nitrendipine inhibit N-type calcium channels in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid (NG 108-15) cells. ( 9259470 )
1997
35
Colocalisation of CTP:choline phosphate cytidylyltransferase (CT) with F-actin accompanies increased phosphatidylcholine synthesis in differentiating neuroblastoma cells. ( 9450022 )
1997
36
Size changes in differentiating neuroblastoma cells. ( 9466674 )
1997
37
Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. ( 9016955 )
1997
38
Detection of delta opioid receptor and N-methyl-D-aspartate receptor-like immunoreactivity in retinoic acid-differentiated neuroblastoma x glioma (NG108-15) cells. ( 8981241 )
1997
39
Vitronectin expression in differentiating neuroblastic tumors: integrin alpha v beta 5 mediates vitronectin-dependent adhesion of retinoic-acid-differentiated neuroblastoma cells. ( 9137089 )
1997
40
Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report. ( 8893739 )
1996
41
The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. ( 8657106 )
1996
42
Production and function of lipid second messengers in proliferating and differentiated neuroblastoma cells. ( 8906581 )
1996
43
Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. ( 18627021 )
1996
44
Biochemical evidence for a mature phenotype in morphologically poorly differentiated neuroblastomas with a favourable outcome. ( 7576941 )
1995
45
Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells. ( 7911712 )
1994
46
Induction of apoptotic cell death in differentiating neuroblastoma SH-SY5Y cells by colchicine. ( 8135827 )
1994
47
Two distinct ATP signaling mechanisms in differentiated neuroblastoma x glioma hybrid NG108-15 cells. ( 7511780 )
1994
48
Radiation therapy of well-differentiated neuroblastoma and central neurocytoma. ( 8339224 )
1993
49
Temporal expression of neurofilament polypeptides in differentiating neuroblastoma cells. ( 1662992 )
1991
50
A lead-associated nuclear protein which increases in maturing brain and in differentiating neuroblastoma 2A cells exposed to cyclic AMP-elevating agents. ( 1708708 )
1990

Variations for Differentiating Neuroblastoma

Expression for Differentiating Neuroblastoma

Search GEO for disease gene expression data for Differentiating Neuroblastoma.

Pathways for Differentiating Neuroblastoma

Pathways related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 BCAR1 MAPK1 SRC
2
Show member pathways
12.1 BCAR1 MAPK1 SRC
3
Show member pathways
12.07 BCAR1 MAPK1 SRC
4
Show member pathways
11.93 BCAR1 MAPK1 SRC
5 11.87 BCAR1 MAPK1 SRC
6 11.67 BCAR1 MAPK1 SRC
7 11.4 MAPK1 SRC
8 11.37 BCAR1 SRC
9 11.34 BCAR1 SRC
10 11.31 MAPK1 SRC
11 11.3 MAPK1 SRC
12 11.28 MAPK1 SRC
13
Show member pathways
11.27 BCAR1 MAPK1
14 11.25 MAPK1 SRC
15
Show member pathways
11.25 BCAR1 SRC
16 11.23 BCAR1 MAPK1 SRC
17 11.16 BCAR1 MAPK1 SRC
18
Show member pathways
11.15 MAPK1 SRC
19 11.12 MAPK1 SRC
20 11.1 MAPK1 SRC
21 11.08 MAPK1 SRC
22 10.99 MAPK1 SRC
23 10.99 BCAR1 MAPK1 SRC
24 10.96 BCAR1 SRC
25 10.93 MAPK1 SRC
26 10.89 MAPK1 SRC
27 10.86 MAPK1 SRC
28 10.71 BCAR1 MAPK1 SRC
29 10.69 MAPK1 SRC
30 10.63 BCAR1 SRC
31 10.16 BCAR1 MAPK1 SRC

GO Terms for Differentiating Neuroblastoma

Biological processes related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.69 MAPK1 MYCN SRC
2 axon guidance GO:0007411 9.54 MAPK1 POU4F2 SRC
3 epidermal growth factor receptor signaling pathway GO:0007173 9.49 BCAR1 SRC
4 positive regulation of axon extension GO:0045773 9.48 MAP1B POU4F2
5 cellular response to reactive oxygen species GO:0034614 9.46 MAPK1 SRC
6 platelet-derived growth factor receptor signaling pathway GO:0048008 9.43 BCAR1 SRC
7 regulation of sequence-specific DNA binding transcription factor activity GO:0051090 9.4 MAPK1 POU4F2
8 axon extension GO:0048675 9.32 MAP1B POU4F2
9 intracellular estrogen receptor signaling pathway GO:0030520 9.26 POU4F2 SRC
10 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 BCAR1 SRC
11 regulation of early endosome to late endosome transport GO:2000641 8.96 MAPK1 SRC
12 response to epidermal growth factor GO:0070849 8.62 ASCL1 MAPK1

Sources for Differentiating Neuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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