MCID: DFF012
MIFTS: 42

Differentiating Neuroblastoma malady

Neuronal diseases category

Summaries for Differentiating Neuroblastoma

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32MalaCards
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MalaCards: Differentiating Neuroblastoma is related to neuroblastoma and pheochromocytoma. An important gene associated with Differentiating Neuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways are Orexin and neuropeptides FF and QRFP bind to their respective receptors and Ca-dependent events. The compounds catecholamine and isoflurane have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and brain, and related mouse phenotypes are behavior/neurological and nervous system.

Aliases & Classifications for Differentiating Neuroblastoma

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8Disease Ontology, 10DISEASES, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

differentiating neuroblastoma 8 10 60


External Ids:

Disease Ontology8 DOID:4160
NCIt39 C42048

Related Diseases for Differentiating Neuroblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Differentiating Neuroblastoma:



Diseases related to differentiating neuroblastoma

Clinical Features for Differentiating Neuroblastoma

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Drugs & Therapeutics for Differentiating Neuroblastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Differentiating Neuroblastoma

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Anatomical Context for Differentiating Neuroblastoma

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32MalaCards
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MalaCards organs/tissues related to Differentiating Neuroblastoma:

32
Bone, Bone marrow, Brain, Skeletal muscle, Adrenal gland, Testes, Monocytes, B cells, Pituitary

Animal Models for Differentiating Neuroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.4PDYN, NTRK1, POU4F2, MYCN, HCRT, HCRTR1
2MP:000363110.1ASCL1, CACNA1B, PDYN, NTRK1, POU4F2, MAP3K10

Publications for Differentiating Neuroblastoma

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50PubMed
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Articles related to Differentiating Neuroblastoma:

(show top 50)    (show all 510)
idTitleAuthorsYear
1
Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells. (23271418)
2013
2
Morphogenetic and neuronal characterization of human neuroblastoma multicellular spheroids cultured under undifferentiated and all-trans-retinoic acid-differentiated conditions. (23710639)
2013
3
Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons. (23939472)
2013
4
Presence of differentiating neuroblasts in bone marrow is a favorable prognostic factor for bone marrow metastatic neuroblastoma at diagnosis. (23483759)
2013
5
Localization of prohibitin in the nuclear matrix and alteration of its expression during differentiation of human neuroblastoma SK-N-SH cells induced by retinoic acid. (21061155)
2011
6
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. (21559466)
2011
7
Localization of nucleophosmin in nuclear matrix and changes in its expression during the differentiation of human neuroblastoma induced by retinoic acid. (20506166)
2010
8
Effects of avermectins on neurite outgrowth in differentiating mouse neuroblastoma N2a cells. (19879343)
2010
9
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. (19647006)
2009
10
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. (19726241)
2009
11
PACAP-38 induces neuronal differentiation of human SH-SY5Y neuroblastoma cells via cAMP-mediated activation of ERK and p38 MAP kinases. (17995938)
2008
12
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation. (18607002)
2008
13
High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. (18780787)
2008
14
HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. (17488478)
2007
15
All-trans-retinoic acid inhibits collapsin response mediator protein-2 transcriptional activity during SH-SY5Y neuroblastoma cell differentiation. (17229153)
2007
16
gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. (17851177)
2007
17
Silencing of MYCN by RNA interference induces growth inhibition, apoptotic activity and cell differentiation in a neuroblastoma cell line with MYCN amplification. (17390021)
2007
18
Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. (16256972)
2006
19
Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells. (15079871)
2004
20
Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells. (15207915)
2004
21
Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. (15548427)
2004
22
Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. (11738505)
2001
23
Effects of SCO-spondin thrombospondin type 1 repeats (TSR) in comparison to Reissner's fiber material on the differentiation of the B104 neuroblastoma cell line. (11456412)
2001
24
p27Kip1 accumulation is associated with retinoic-induced neuroblastoma differentiation: evidence of a decreased proteasome-dependent degradation. (10644979)
2000
25
Induction of two DNA mismatch repair proteins, MSH2 and MSH6, in differentiated human neuroblastoma SH-SY5Y cells exposed to doxorubicin. (10037468)
1999
26
Differentiation of neuroblastoma cells by phorbol esters and insulin-like growth factor 1 is associated with induction of retinoic acid receptor beta gene expression. (10498893)
1999
27
Differential effects of retinoic acid isomers on the expression of nuclear receptor co-regulators in neuroblastoma. (10094499)
1999
28
Downregulation of glycogen synthase kinase-3beta (GSK-3beta) protein expression during neuroblastoma IMR-32 cell differentiation. (10348658)
1999
29
Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. (9605760)
1998
30
A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage. (8941212)
1996
31
Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells. (8780891)
1996
32
Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP. (7598686)
1995
33
Expression of brain-derived neurotrophic factor and p145TrkB affects survival, differentiation, and invasiveness of human neuroblastoma cells. (7712490)
1995
34
Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein. (7837790)
1995
35
Ethanol and naloxone differentially upregulate delta opioid receptor gene expression in neuroblastoma hybrid (NG108-15) cells. (7877460)
1994
36
Changing expression of GTPase activating proteins with differentiation in neuroblastoma. (7853016)
1994
37
Activation of the human NPY gene during neuroblastoma cell differentiation: induced transcriptional activities of AP-1 and AP-2. (8123590)
1994
38
Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Eukaryotic Signal Transduction Group. (8394722)
1993
39
Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells. (1425774)
1992
40
Platelet-derived growth factor potentiates phorbol ester-induced neuronal differentiation of human neuroblastoma cells. (1467306)
1992
41
Protein kinase C remains functionally active during TPA induced neuronal differentiation of SH-SY5Y human neuroblastoma cells. (1506412)
1992
42
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants. (1354203)
1992
43
Up-regulation of the integrin alpha 1/beta 1 in human neuroblastoma cells differentiated by retinoic acid: correlation with increased neurite outgrowth response to laminin. (1839359)
1991
44
Differential expression of N-myc in phenotypically distinct subclones of a human neuroblastoma cell line. (1933896)
1991
45
Divergent changes of chromogranin A/secretogranin II levels in differentiating human neuroblastoma cells. (2365053)
1990
46
Retinoic acid induced differentiated neuroblastoma cells show increased expression of the beta A4 amyloid gene of Alzheimer's disease and an altered splicing pattern. (2205513)
1990
47
Tubulin pools in differentiating neuroblastoma cells. (7251659)
1981
48
Complexity of polysomal poly(A)RNA in different developmental stages of a non-differentiating neuroblastoma clone. (7215538)
1980
49
Specific alterations in phosphorylation of cytosol proteins from differentiating neuroblastoma cells grown in culture. (189207)
1977
50
A differentiating neuroblastoma. (5843953)
1965

Genetic Variations for Differentiating Neuroblastoma

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Expression for genes affiliated with Differentiating Neuroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Differentiating Neuroblastoma

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Pathways for genes affiliated with Differentiating Neuroblastoma

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53Reactome, 49PharmGKB
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Pathways related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5HCRTR1, HCRT
2
Hide members
10.5NTRK1, PDYN, CACNA1B

Compounds for genes affiliated with Differentiating Neuroblastoma

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1catecholamine4410.8HCRT, MYCN, NTRK1, PDYN
2isoflurane44 1111.8CACNA1B, HCRT, HCRTR1
3dopamine44 28 11 2413.8ASCL1, CACNA1B, PDYN, PDE3B, NTRK1, MYCN
4potassium44 11 2412.8CACNA1B, PDYN, PDE3B, NTRK1, HCRT, HCRTR1
5acth4410.8PDYN, PDE3B, IGFBP5, HCRT, HCRTR1
6acetylcholine44 49 28 11 2414.8HCRTR1, HCRT, NTRK1, PDYN, CACNA1B
7ceramide4410.7PDE3B, TFPT, NTRK1, IGFBP5
8capsaicin44 2811.7CACNA1B, PDYN, NTRK1
9alanine4410.7CACNA1B, TFPT, NTRK1, IGFBP5, HCRT, HCRTR1
10opiate4410.7HCRT, NTRK1, PDYN
11calcium44 49 11 2413.7CACYBP, CACNA1B, PDYN, PDE3B, NTRK1, IGFBP5
12adenylate4410.6PDYN, PDE3B, NTRK1, HCRT, HCRTR1
13ribonucleic acid4410.6PDYN, IGFBP5, HCRT, HCRTR1
14npff4410.6HCRT, PDYN
15cholesterol44 28 11 2413.5CACNA1B, PDE3B, TFPT, IGFBP5, HCRT
16serine4410.5COIL, PDE3B, TFPT, NTRK1, IGFBP5, MAP3K10
17gtp44 2811.4TGM3, PDE3B, PDYN, CACNA1B
18tyrosine4410.4PDYN, PDE3B, NTRK1, IGFBP5, MYCN, HCRT
19quinpirole44 2811.4CACNA1B, PDYN
20glycosphingolipid4410.2TFPT, NTRK1

GO Terms for genes affiliated with Differentiating Neuroblastoma

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16Gene Ontology
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Biological processes related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:04848510.5ASCL1, NTRK1
2neuropeptide signaling pathwayGO:00721810.4HCRTR1, HCRT, PDYN
3synaptic transmissionGO:00726810.2HCRTR1, HCRT, PDYN, CACNA1B

Molecular functions related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.5ASCL1, MAP3K10

Products for genes affiliated with Differentiating Neuroblastoma

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Sources for Differentiating Neuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet