MCID: DFF012
MIFTS: 37

Differentiating Neuroblastoma malady

Neuronal category

Summaries for Differentiating Neuroblastoma

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33MalaCards
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MalaCards: Differentiating Neuroblastoma is related to pheochromocytoma and neuroendocrine carcinoma. An important gene associated with Differentiating Neuroblastoma is MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog), and among its related pathways are Orexin and neuropeptides FF and QRFP bind to their respective receptors and Ca-dependent events. The compounds catecholamine and isoflurane have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and adrenal gland, and related mouse phenotypes are behavior/neurological and nervous system.

Aliases & Classifications for Differentiating Neuroblastoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

differentiating neuroblastoma 8 10 61


External Ids:

Disease Ontology8 DOID:4160
NCIt40 C42048

Related Diseases for Differentiating Neuroblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Differentiating Neuroblastoma:



Diseases related to differentiating neuroblastoma

Clinical Features for Differentiating Neuroblastoma

Drugs & Therapeutics for Differentiating Neuroblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Differentiating Neuroblastoma

Drug clinical trials:

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Search NIH Clinical Center for Differentiating Neuroblastoma

Search CenterWatch for Differentiating Neuroblastoma

Genetic Tests for Differentiating Neuroblastoma

Anatomical Context for Differentiating Neuroblastoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Differentiating Neuroblastoma:

33
Bone marrow, Brain, Adrenal gland, B cells, Pituitary

Animal Models for Differentiating Neuroblastoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.4CACNA1B, PDYN, NTRK1, POU4F2, MYCN, HCRT
2MP:000363110.1CACNA1B, PDYN, NTRK1, POU4F2, MAP3K10, MYCN

Publications for Differentiating Neuroblastoma

Sources:
51PubMed
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Articles related to Differentiating Neuroblastoma:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Presence of differentiating neuroblasts in bone marrow is a favorable prognostic factor for bone marrow metastatic neuroblastoma at diagnosis. (23483759)
2013
2
Mu-opioid signaling modulates biphasic expression of TrkB and II_BI+ genes and neurite outgrowth in differentiating and differentiated human neuroblastoma cells. (23422506)
2013
3
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. (21559466)
2011
4
Effects of avermectins on neurite outgrowth in differentiating mouse neuroblastoma N2a cells. (19879343)
2010
5
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. (19318809)
2009
6
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. (19647006)
2009
7
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells. (19735367)
2009
8
Differentiating neuroblastoma arising in mediastinal germ cell tumour. (18631196)
2008
9
Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. (17490655)
2007
10
Cholesterol supports the retinoic acid-induced synaptic vesicle formation in differentiating human SH-SY5Y neuroblastoma cells. (17540009)
2007
11
Effect of carbamate esters on neurite outgrowth in differentiating human SK-N-SH neuroblastoma cells. (16256972)
2006
12
Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. (15548427)
2004
13
Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. (11606272)
2001
14
Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF. (11257453)
2001
15
A mathematical model for assessing changes in neurofilament protein levels in neurites and cell bodies of differentiating neuroblastoma cells. (10873435)
2000
16
Activation and protein kinase C-dependent nuclear accumulation of ERK in differentiating human neuroblastoma cells. (10772818)
2000
17
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. (10080936)
1999
18
Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. (9442079)
1998
19
Activated transcription of the human neuropeptide Y gene in differentiating SH-SY5Y neuroblastoma cells is dependent on transcription factors AP-1, AP-2alpha, and NGFI. (9572272)
1998
20
Vitronectin expression in differentiating neuroblastic tumors: integrin alpha v beta 5 mediates vitronectin-dependent adhesion of retinoic-acid-differentiated neuroblastoma cells. (9137089)
1997
21
Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. (9016955)
1997
22
Size changes in differentiating neuroblastoma cells. (9466674)
1997
23
Colocalisation of CTP:choline phosphate cytidylyltransferase (CT) with F-actin accompanies increased phosphatidylcholine synthesis in differentiating neuroblastoma cells. (9450022)
1997
24
Alteration of intracellular free calcium and acylphosphatase levels in differentiating SH-SY5Y neuroblastoma cells. (9352082)
1997
25
A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage. (8941212)
1996
26
The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. (8657106)
1996
27
Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells? (9025718)
1996
28
Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells. (8780891)
1996
29
Hox gene expression in differentiating human neuroblastoma cells. (8104620)
1993
30
Human GAP-43 Gene Expression: Multiple Start Sites for Initiation of Transcription in Differentiating Human Neuroblastoma Cells. (19912963)
1993
31
Uncoordinate induction and differential regulation of HLA class-I and class-II expression by gamma-interferon in differentiating human neuroblastoma cells. (8244579)
1993
32
Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells. (8344756)
1993
33
Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells. (1425774)
1992
34
Divergent changes of chromogranin A/secretogranin II levels in differentiating human neuroblastoma cells. (2365053)
1990
35
Characterization and intracellular distribution of microtubule-associated protein 2 in differentiating human neuroblastoma cells. (1696615)
1990
36
Cyclic AMP-dependent expression of the heavy neurofilament (NF-H) polypeptide in differentiating neuroblastoma cells. (2160043)
1990
37
Surface glycoproteins of differentiating neuroblastoma cells analyzed by lectin binding and flow cytometry. (3665675)
1987
38
A short-term screening test for teratogens using differentiating neuroblastoma cells in vitro. (6740511)
1984
39
Ultrastructural changes in differentiating neuroblastoma x glioma hybrid cells. (6320493)
1983
40
Modulation in the levels and localization of plasminogen activator in differentiating neuroblastoma cells. (6133597)
1983
41
DNA synthesis in differentiating neuroblastoma cells following induction by glioma cells. (7083276)
1982
42
Tubulin pools in differentiating neuroblastoma cells. (7251659)
1981
43
Lateral diffusion of membrane D-galactosyl glycoconjugates of differentiating neuroblastoma cells. (7332554)
1981
44
Acyltransferase activity and cytochemical localization in differentiating neuroblastoma. (7307080)
1981
45
A pigmented differentiating neuroblastoma: a light and ultrastructural study. (7397624)
1980
46
Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells. (508746)
1979
47
Specific alterations in phosphorylation of cytosol proteins from differentiating neuroblastoma cells grown in culture. (189207)
1977
48
Increased rate of acetylcholinesterase synthesis in differentiating neuroblastoma cells. (4548065)
1974
49
Rates of oxygen uptake in proliferating and differentiating neuroblastoma cells. (5025651)
1972
50
A differentiating neuroblastoma. (5843953)
1965

Genetic Variations for Differentiating Neuroblastoma

Expression for genes affiliated with Differentiating Neuroblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Differentiating Neuroblastoma

Search GEO for disease gene expression data for Differentiating Neuroblastoma.

Pathways for genes affiliated with Differentiating Neuroblastoma

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54Reactome, 50PharmGKB
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Pathways related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5HCRTR1, HCRT
2
Hide members
10.5NTRK1, PDYN, CACNA1B

Compounds for genes affiliated with Differentiating Neuroblastoma

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB
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Compounds related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1catecholamine4510.8HCRT, MYCN, NTRK1, PDYN
2isoflurane45 1111.8CACNA1B, HCRT, HCRTR1
3dopamine45 29 11 2413.8ASCL1, CACNA1B, PDYN, PDE3B, NTRK1, MYCN
4potassium45 11 2412.8CACNA1B, PDYN, PDE3B, NTRK1, HCRT, HCRTR1
5acth4510.8PDYN, PDE3B, IGFBP5, HCRT, HCRTR1
6acetylcholine45 50 29 11 2414.8HCRTR1, HCRT, NTRK1, PDYN, CACNA1B
7ceramide4510.7PDE3B, TFPT, NTRK1, IGFBP5
8capsaicin45 2911.7CACNA1B, PDYN, NTRK1
9alanine4510.7CACNA1B, TFPT, NTRK1, IGFBP5, HCRT, HCRTR1
10opiate4510.7HCRT, NTRK1, PDYN
11calcium45 50 11 2413.7CACYBP, CACNA1B, PDYN, PDE3B, NTRK1, IGFBP5
12adenylate4510.6PDYN, PDE3B, NTRK1, HCRT, HCRTR1
13ribonucleic acid4510.6PDYN, IGFBP5, HCRT, HCRTR1
14npff4510.6HCRT, PDYN
15cholesterol45 29 11 2413.5CACNA1B, PDE3B, TFPT, IGFBP5, HCRT
16serine4510.5COIL, PDE3B, TFPT, NTRK1, IGFBP5, MAP3K10
17gtp45 2911.4TGM3, PDE3B, PDYN, CACNA1B
18tyrosine4510.4PDYN, PDE3B, NTRK1, IGFBP5, MYCN, HCRT
19quinpirole45 2911.4CACNA1B, PDYN
20glycosphingolipid4510.2TFPT, NTRK1

GO Terms for genes affiliated with Differentiating Neuroblastoma

Sources:
16Gene Ontology
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Biological processes related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sympathetic nervous system developmentGO:04848510.5ASCL1, NTRK1
2neuropeptide signaling pathwayGO:00721810.4HCRTR1, HCRT, PDYN
3synaptic transmissionGO:00726810.2HCRTR1, HCRT, PDYN, CACNA1B

Molecular functions related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.5ASCL1, MAP3K10

Products for genes affiliated with Differentiating Neuroblastoma

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Sources for Differentiating Neuroblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet