Differentiating Neuroblastoma malady

MalaCards: Differentiating Neuroblastoma is related to dysautonomia and neuroendocrine tumor. An important gene associated with Differentiating Neuroblastoma is MIR10A (microRNA 10a), and among its related pathways are Signal transduction_PTEN pathway and Breast Cancer Regulation by Stathmin1. The compounds carbachol and glucose have been mentioned in the context of this disorder. Affiliated tissues include b cells and pituitary, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Aliases & Descriptions:

differentiating neuroblastoma 6 8 43

Diseases related to differentiating neuroblastoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 706)

id	Related Disease	Score	Top Affiliating Genes
1	dysautonomia	29.0	BDNF, IKBKAP, HSPG2, NTRK1, SNCA, NGF
2	neuroendocrine tumor	28.3	RET, MYCN, CHGA, ASCL1, CCNB1, GNAS
3	frontotemporal dementia	27.9	BDNF, CHGA, APP, MAPT, SNCA, RPS27A
4	merkel cell carcinoma	26.1	BCL2, CHGA, ASCL1, MAPK1, TP53, TNF
5	dementia	20.5	BDNF, BCL2, CHGA, CDK5, IL6, APP
6	pheochromocytoma	19.7	RET, MYCN, BCL2, CHGA, FOS, ASCL1
7	neuroblastoma	19.0	PDE3B, RET, VTN, VBP1, MYCN, MYBL2
8	adenoma	17.7	RET, BMP2, RARA, BCL2, CHGA, ATM
9	riley-day syndrome	13.9	BDNF, IKBKAP, NTRK1
10	hereditary sensory neuropathy	13.8	IKBKAP, NTRK1, NGF
11	ewing's family of tumors	13.7	MYCN, CHGA, NGF, SYP
12	central neurocytoma	13.7	CHGA, SNCA, SYP
13	large cell carcinoma	13.7	CHGA, HRAS, KRT20, SYP
14	primary polycythemia	13.7	STAT5A, EPO, EPOR
15	familial medullary thyroid carcinoma	13.7	RET, MYCN, CHGA, ASCL1, NTRK1, CREB1
16	endocrine gland cancer	13.7	RET, CHGA, GNAS, SYP
17	congenital central hypoventilation syndrome	13.6	RET, BDNF, ASCL1, TH
18	thyroid cancer	13.6	RET, HSPG2, KRT20, ADCY10
19	opiate dependence	13.6	DRD3, CREB1, TH, ADCY10
20	central hypoventilation syndrome	13.6	RET, BDNF, ASCL1, TH
21	neuroaxonal dystrophy	13.6	NTRK1, SNCA, RPS27A, NGF
22	follicular adenoma	13.5	RET, GNAS, HSPG2, HRAS, NTRK1, KRT20
23	rectum sarcomatoid carcinoma	13.5	BMP2, CHGA, HRAS, SYP
24	binswanger's disease	13.5	APP, MAPT, SYP
25	nicotine dependence	13.5	BDNF, FOS, DRD3, SHC3, TH, ADCY1
26	cerebral hypoxia	13.5	FOS, APP, CREB1, NOS1
27	supratentorial neoplasm	13.5	CHGA, SYP, PRL
28	hirschsprung's disease	13.5	RET, NTRK1, NOS1, SYP
29	peripheral primitive neuroectodermal tumor	13.5	MYCN, CHGA, CCND3, IGF2, NTRK1, TH
30	niemann-pick disease type c1	13.5	APP, MAPT, SNCA, HCRT
31	down syndrome	13.5	MYCN, RARA, ATM, APP, DUSP19
32	early-onset familial alzheimer disease	13.5	APP, MAPT, SNCA
33	anhidrosis	13.4	BDNF, MAPK1, IKBKAP, NTRK1, NGF
34	central nervous system disease	13.4	BDNF, APP, MAPT, NGF, HCRT
35	carcinoid syndrome	13.4	CHGA, IGF1, SYP, KNG1
36	inclusion body myositis	13.4	APP, MAPT, RPS27A
37	drug addiction	13.4	BDNF, MAPK1, DRD3, CREB1, PDYN, HCRT
38	proliferative vitreoretinopathy	13.4	VTN, FOS, THBS1, ADAMTSL1
39	congestive heart failure	13.4	PDE3B, NOS1, PDYN, KNG1, EPO, EPOR
40	dry eye syndrome	13.4	BDNF, IL6, HSPG2, NGF
41	mesenchymal cell neoplasm	13.3	IGF1, HRAS, AKT1, SYP
42	cognitive disease	13.3	BDNF, APP, MAPT, DRD3, SNCA
43	myeloproliferative disorder	13.3	HRAS, CREB1, STAT5A, EPO, EPOR
44	lower motor neuron disease	13.3	SMN1, SYP, SOD1
45	fibrodysplasia ossificans progressiva	13.3	BMP2, FOS, MAPK1, GNAS
46	pancreatic islet cell tumors	13.3	RET, CHGA, IGF2, IGF1, SYP
47	carney complex	13.3	CHGA, GNAS, SYP, PRL
48	olivopontocerebellar atrophy	13.3	MAPT, SNCA, RPS27A, TH
49	mood disorder	13.3	BDNF, DRD3, CREB1, NOS1, PDYN, HCRT
50	interleukin receptor	13.3	FOS, IL6, NGF, KNG1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to differentiating neuroblastoma:

²²

MGI Mouse Phenotypes related to differentiating neuroblastoma:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	RET, KDM1A, ASCL1, IFNG, GNAS, CACNA1B
2	craniofacial phenotype	MP:0005382	9.6	SIRT1, RXRA, SMN1, HSPG2, GNAS, IKBKAP
3	respiratory system phenotype	MP:0005388	9.6	RET, MYCN, BDNF, CDK5, ASCL1, SMN1
4	hematopoietic system phenotype	MP:0005397	9.6	MYCN, BCL2, ATM, FOXO3, IKBKAP, IGF2
5	pigmentation phenotype	MP:0001186	9.0	SOD2, RXRA, NTRK1, SRC, TP53, ASCL1
6	renal/urinary system phenotype	MP:0005367	8.6	DRD3, SNCA, RXRA, THBS1, TGM2, SOD2
7	embryogenesis phenotype	MP:0005380	8.6	SMN1, CREB1, RXRA, TFDP1, PRL, ADAM17
8	limbs/digits/tail phenotype	MP:0005371	8.4	NTRK1, SMN1, RXRA, LTA, THBS1, SIRT1
9	digestive/alimentary phenotype	MP:0005381	8.0	SNCA, SMN1, NOS1, RXRA, PDYN, THBS1
10	hearing/vestibular/ear phenotype	MP:0005377	7.9	NTRK1, SMN1, RXRA, SOD1, SOD2, POU4F2
11	no phenotypic analysis	MP:0003012	7.7	TP53, NTRK1, SNCA, SMN1, AGER, TGM2
12	adipose tissue phenotype	MP:0005375	7.3	DRD3, NOS1, PDYN, TGFA, STAT5A, SOD2
13	liver/biliary system phenotype	MP:0005370	6.8	STAT5A, PRL, SOD1, LYN, SIRT1, EPO
14	skeleton phenotype	MP:0005390	6.7	SRC, SNCA, SMN1, NOS1, RXRA, PDYN
15	normal phenotype	MP:0002873	6.3	RET, VTN, NTRK1, SMN1, CREB1, NOS1
16	integument phenotype	MP:0010771	5.9	SRC, NTRK1, SNCA, SMN1, RXRA, NGF
17	reproductive system phenotype	MP:0005389	5.8	RET, MYCN, BMP2, RARA, SOD2, SIRT1
18	nervous system phenotype	MP:0003631	5.8	HRAS, AKT1, DRD3, SRC, NTRK1, NRD1
19	immune system phenotype	MP:0005387	5.7	ADAM17, EPOR, SIRT1, GNAS, HSPG2, CACYBP
20	vision/eye phenotype	MP:0005391	5.5	ASCL1, IL6, MAPT, CCND3, IKBKAP, IGF2
21	tumorigenesis	MP:0002006	5.3	CCND3, IGF1, IFNG, HRAS, AKT1, TP53
22	muscle phenotype	MP:0005369	5.2	TNF, NTRK1, SMN1, CREB1, NOS1, RXRA
23	growth/size phenotype	MP:0005378	4.5	PDE3B, RET, MYCN, BMP2, HRAS, AKT1
24	mortality/aging	MP:0010768	4.3	RET, CCND3, IKBKAP, IFNG, GNAS, HSPG2
25	cardiovascular system phenotype	MP:0005385	3.7	BMP2, HRAS, AKT1, TP53, TNF, DRD3
26	behavior/neurological phenotype	MP:0005386	3.7	MYCN, BIN1, BDNF, ATM, CDK5, FOS
27	cellular phenotype	MP:0005384	2.5	TP53, POU4F2, LYN, SIRT1, ADAM17, EPO
28	homeostasis/metabolism phenotype	MP:0005376	1.5	HSPG2, THBS1, TGM2, STAT5A, PRL, SOD1

Articles related to differentiating neuroblastoma:

(show top 50)    (show all 70)

id	Title	Authors	Year	Affiliating Genes
1	Rab15 expression correlates with retinoic acid-induce d differentiation of neuroblastoma cells. (21491086)	Nishimura N.... Matsuo M.	2011	RAB15
2	Nuclear GRP75 binds retinoic acid receptors to promot e neuronal differentiation of neuroblastoma. (22022577)	Shih Y.Y.... Liao Y.F.	2011	RARA, RXRA, HSPA9
3	Effects of IKAP/hELP1 deficiency on gene expression i n differentiating neuroblastoma cells: implications for familial dysautonomia. (21559466)	Cohen-Kupiec R.... Weil M.	2011	IKBKAP
4	Differentiation in neuroblastoma: diffusion-limited h ypoxia induces neuro-endocrine secretory protein 55 and other markers of a chro maffin phenotype. (20862257)	Hedborg F.... Maxwell P.H.	2010	GNAS
5	A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. (19318809)	Vanchinathan V.... Sundram U.N.	2009	KRT20
6	Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. (19223552)	Schulte J.H.... Kirfel J.	2009	KDM1A
7	Vitamin B12 deficiency reduces proliferation and prom otes differentiation of neuroblastoma cells and up-regulates PP2A, proNGF, and TACE. (19959661)	Battaglia-Hsu S.F.... GuAcant J.L.	2009	ADAM17
8	Isoflurane attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in differentiated neuroblastoma SH-SY5Y cells. (19032555)	Wu G.J.... Wen Z.H.	2009	PDYN
9	Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. (19726241)	Jiang Y.... Kelley M.R.	2009	APEX1
10	BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress. (19050044)	Baj G.... Enrico T.	2009	BDNF
11	Effect of cell differentiation for neuroblastoma by vitamin k analogs. (19273458)	Nakayama T.... Suzuki T.	2009	NTRK1, ACP1
12	Promyelocytic leukemia-nuclear body formation is an e arly event leading to retinoic acid-induced differentiation of neuroblastoma ce lls. (17986232)	Delaune A.... Vasse M.	2008	MAPK1
13	Transglutaminase 2 and NF-kappaB interplay during NGF-induced differentiation of neuroblastoma cells. (18374307)	Condello S.... Ientile R.	2008	TGM2, NGF, TGM3
14	Tumor necrosis factor alpha regulates responses to nerve growth factor, promoting neural cell survival but suppressing differentiation of neuroblastoma cells. (18094051)	Takei Y.... Laskey R.	2008	TNF
15	Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. (17490655)	Calissano M.... Latchman D.S.	2007	POU4F2
16	p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma. (17912039)	Chen L.... Tweddle D.A.	2007	TP53
17	Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line. (17559250)	Cimmino F.... Iolascon A.	2007	VBP1
18	A 'classical' homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. (17045782)	Um M.... Lodish H.F.	2007	EPO
19	A novel cyclophane compound, CPPy, facilitates NGF-induced TrkA signal transduction and induces cell differentiation in neuroblastoma. (17409494)	Yamaguchi Y.... Suzuki T.	2007	NTRK1, FOS
20	Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. (17426037)	Fernandes N.D.... Price B.D.	2007	ATM, CREB1
21	The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells. (17050705)	Nasman J.... Akerman K.E.	2006	HCRTR1, HCRT
22	Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. (16407271)	Um M.... Lodish H.F.	2006	AKT1, STAT5A, EPOR
23	Selenomethionine prevents degeneration induced by overexpression of wild-type human alpha-synuclein during differentiation of neuroblastoma cells. (16373949)	Kumar B.... Prasad K.N.	2005	PDE3B, ADCY10
24	Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells. (15079871)	Prasad J.E.... Prasad K.N.	2004	SNCA
25	Insulin-like growth factor binding protein 5: contribution to growth and differentiation of neuroblastoma cells. (15650232)	Cesi V.... RaschellA G.	2004	IGFBP5
26	Gene and protein expression profiling during differentiation of neuroblastoma cells triggered by 13-cis retinoic acid. (12972807)	Yuza Y.... Urashima M.	2003	CCND3, TFDP1, MYCN
27	Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells. (13130517)	Hanson A.J.... Prasad K.N.	2003	APP
28	Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells. (14515147)	Kania J.... Guzdek A.	2003	SOD2
29	Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH- SY5Y cells. (12895292)	Wu J.... Qiang B.Q.	2003	CACYBP
30	Estrogen receptor alpha, a molecular switch converting transforming growth factor-alpha-mediated proliferation into differentiation in neuroblastoma cells. (12709435)	Ciana P.... Maggi A.	2003	TGFA
31	Increased resistance to nitric oxide cytotoxicity associated with differentiation of neuroblastoma-glioma hybrid (NG108-15) cells. (12150542)	Kawahara K.... Ito E.	2002	SOD1, NOS1
32	Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells. (11860188)	Nahreini P.... Prasad K.N.	2001	CCNB1, MYCN
33	Retinoic acid evoked-differentiation of neuroblastoma cells predominates over growth factor stimulation: an automated image capture and quantitation approach to neuritogenesis. (11757502)	Simpson P.B.... Kerby J.	2001	NGF
34	Significance of gangliosides in neuronal differentiation of neuroblastoma cells and neurite growth in tissue culture. (9668353)	RAPsner H.	1998	TFPT
35	Vitronectin expression in differentiating neuroblastic tumors: integrin alpha v beta 5 mediates vitronectin-dependent adhesion of retinoic-acid-differentiated neuroblastoma cells. (9137089)	Gladson C.L.... Grammer J.R.	1997	VTN
36	Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. (9016955)	Kito K.... Sakaki Y.	1997	C4orf6
37	Nimodipine and nitrendipine inhibit N-type calcium channels in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid (NG 108-15) cells. (9259470)	Li S.N.... Andreas K.	1997	CACNA1B
38	Involvement of a ceramide activated protein phosphata se in the differentiation of neuroblastoma Neuro2a cells. (9315744)	Prinetti A.... Tettamanti G.	1997	DUSP19
39	Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report. (8893739)	Lach B.... Staines W.	1996	PRL
40	Production and function of lipid second messengers in proliferating and differentiated neuroblastoma cells. (8906581)	Lang D.... Freysz L.	1996	HSPG2
41	Retinoic acid-induced growth arrest and differentiation of neuroblastoma cells are counteracted by N-myc and enhanced by max overexpressions. (8570225)	Peverali F.A.... Della-Valle G.	1996	MYCN
42	Retinoic acid and cAMP differentially regulate human chromogranin A promoter activity during differentiation of neuroblastoma cells. (7576943)	Gaetano C.... Sacchi A.	1995	CHGA
43	Biochemical evidence for a mature phenotype in morphologically poorly differentiated neuroblastomas with a favourable outcome. (7576941)	Hedborg F.... PAYhlman S.	1995	SYP
44	Differentiation of neuroblastoma enhances Bcl-2 expre ssion and induces alterations of apoptosis and drug resistance. (7553653)	Lasorella A.... Israel M.A.	1995	BCL2
45	Tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin-6 but not TNF-beta induce differentiation of neuroblastoma cells: the role of nitric oxide. (7510778)	MuA+oz-FernA!ndez M.A.... Fresno M.	1994	TNF, IL6, IFNG
46	Two distinct ATP signaling mechanisms in differentiated neuroblastoma x glioma hybrid NG108-15 cells. (7511780)	Chueh S.H.... Song S.L.	1994	KNG1
47	Changing expression of GTPase activating proteins wit h differentiation in neuroblastoma. (7853016)	Burchill S.A.... Lewis I.J.	1994	HRAS
48	Expression of the B cell-associated tyrosine kinase gene Lyn in primary neuroblastoma tumours and its modulation during the differentiation of neuroblastoma cell lines. (1510669)	Bielke W.... Miescher G.C.	1992	LYN
49	Change in adenyl cyclase activity in the differentiation of neuroblastoma cells (2172886)	Busse E.... Kornhuber B.	1990	ADCY1
50	Retinoic acid induced differentiated neuroblastoma ce lls show increased expression of the beta A4 amyloid gene of Alzheimer's diseas e and an altered splicing pattern. (2205513)	KAPnig G.... Beyreuther K.	1990	NGF

Genes related to differentiating neuroblastoma according to GeneCards:

(show top 50)    (show all 93)

id	Symbol	Description	Score	GeneCards Section Context
1	MIR10A	microRNA 10a	11.0	Publications
2	C4orf6	chromosome 4 open reading frame 6	11.0	Publications
3	MIR10B	microRNA 10b	11.0	Publications
4	RAB15	RAB15, member RAS oncogene family	11.0	Publications
5	CACYBP	calcyclin binding protein	11.0	Publications
6	NGRN	neugrin, neurite outgrowth associated	11.0	Publications
7	POU4F2	POU class 4 homeobox 2	11.0	Publications
8	VBP1	von Hippel-Lindau binding protein 1	11.0	Publications
9	TFPT	TCF3 (E2A) fusion partner (in childhood Leukemia)	11.0	Publications
10	COIL	coilin	11.0	Publications
11	MAP3K10	mitogen-activated protein kinase kinase kinase 10	11.0
12	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0	Functions
13	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
14	TGM3	transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
15	HCRTR1	hypocretin (orexin) receptor 1	11.0	Publications
16	IGFBP5	insulin-like growth factor binding protein 5	11.0	Publications
17	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
18	EPOR	erythropoietin receptor	11.0	Publications
19	HSPA9	heat shock 70kDa protein 9 (mortalin)	11.0	Publications
20	FOXO3	forkhead box O3	11.0	Publications
21	TFDP1	transcription factor Dp-1	11.0	Publications
22	HMGB1	high mobility group box 1	11.0	Publications
23	PDYN	prodynorphin	11.0	Publications
24	KRT20	keratin 20	11.0	Publications
25	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0	Publications
26	KDM1A	lysine (K)-specific demethylase 1A	11.0	Publications
27	PDE3B	phosphodiesterase 3B, cGMP-inhibited	11.0	Publications
28	IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	11.0	Publications
29	MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	11.0	Publications
30	NRD1	nardilysin (N-arginine dibasic convertase)	11.0
31	SHC3	SHC (Src homology 2 domain containing) transforming protein 3	11.0	Publications
32	BCAR1	breast cancer anti-estrogen resistance 1	11.0	Publications
33	TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	11.0	Publications
34	ADCY1	adenylate cyclase 1 (brain)	11.0	Publications
35	BIN1	bridging integrator 1	11.0	Publications
36	SYP	synaptophysin	11.0	Publications
37	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	11.0	Publications
38	ADAM17	ADAM metallopeptidase domain 17	11.0	Publications
39	TUBA1B	tubulin, alpha 1b	11.0	Publications
40	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
41	STAT5A	signal transducer and activator of transcription 5A	11.0	Publications
42	DUSP19	dual specificity phosphatase 19	11.0	Publications
43	SIRT1	sirtuin 1	11.0	Publications
44	RARA	retinoic acid receptor, alpha	11.0	Publications
45	THBS1	thrombospondin 1	11.0	Publications
46	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
47	RXRA	retinoid X receptor, alpha	11.0	Publications
48	TGFA	transforming growth factor, alpha	11.0	Publications
49	VTN	vitronectin	11.0	Publications
50	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications

Pathways related to differentiating neuroblastoma according to GeneDecks:

(show top 50)    (show all 250)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.8	BCAR1
2	Breast Cancer Regulation by Stathmin136	10.3	NTRK1, CCNB1, ADCY1, BMP2, TGFA
3	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.0	NGF, NTRK1, CDK5, BCL2
4	Neurotrophin signaling pathway20	9.7	FOXO3, BDNF, MAPK1, HRAS, NGF, SHC3
5	CREB Pathway36	9.7	IGF2, IGF1, ADCY1, BMP2, BDNF, CREB1
6	Development IGF-RI signaling10	9.4	AKT1, HRAS, IGF2, IGFBP5, FOXO3, IGF1
7	PTEN Pathway36	9.3	NTRK1, TP53, HRAS, HSPG2, MAPK1, BCAR1
8	Development_IGF-1 receptor signaling41	9.3	IGF1, AKT1, CREB1, IGF2, HRAS, CCND3
9	Development_Neurotrophin family signaling41	9.2	NGF, TP53, AKT1, NTRK1, HRAS, MAPK1
10	Development Neurotrophin family signaling10	9.1	NGF, NTRK1, TP53, AKT1, BDNF, MAPK1
11	Development_EPO-induced Jak-STAT pathway41	9.1	MAPK1, SRC, STAT5A, EPO, BCL2, LYN
12	Pathways in cancer20	9.1	FOS, AKT1, MAPK1, NTRK1, RXRA, TGFA
13	Signal transduction PTEN pathway10	9.0	HRAS, MAPK1, FOXO3, BCAR1, SRC, IGF1
14	Akt Signaling36	9.0	AKT1, EPOR, LTA, CCND3, IL6, BMP2
15	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.9	NGF, NTRK1, TP53, BCL2, CDK5, MAPK1
16	Alzheimers Disease Pathway36	8.9	MAPT, APP, SRC, ADAM17, MAPK1, EPOR
17	Development EPO-induced Jak-STAT pathway10	8.9	LYN, EPO, EPOR, MAPK1, BCL2, STAT5A
18	Telomerase Components in Cell Signaling36	8.8	BDNF, NTRK1, TP53, AKT1, IGF1, ATM
19	ILK Signaling36	8.7	BMP2, EPOR, TGFA, BCAR1, CREB1, NTRK1
20	Focal adhesion20	8.7	SHC3, MAPK1, VTN, BCL2, CCND3, THBS1
21	ERK5 Signaling36	8.7	TGFA, CREB1, NTRK1, AKT1, HRAS, IL6
22	Neuroscience3	8.6	RET, SYP, TH, MYCN, CDK5, APEX1
23	HMGB1 Pathway36	8.5	HMGB1, FOS, AKT1, HRAS, IFNG, MAPK1
24	Endothelin-1 Signaling Pathway36	8.5	NTRK1, MAPK1, EPOR, NOS1, SRC, IL6
25	MAPK signaling pathway20	8.4	NGF, FOS, NTRK1, MAPT, TP53, TNF
26	PPAR Pathway36	8.3	AKT1, NTRK1, RXRA, LTA, TNF, IGF2
27	14-3-3 Induced Intracellular Signaling36	8.2	MAPT, BDNF, MAPK1, IGF1, HRAS, AKT1
28	ERK Signaling36	8.1	IGF2, ADCY1, MAPK1, CREB1, TGFA, SRC
29	p53 Mediated Apoptosis36	8.1	TGFA, NTRK1, TP53, AKT1, IGF1, IGF2
30	Mitochondrial Apoptosis36	8.0	AKT1, IGF2, BMP2, ATM, IGF1, TP53
31	Apoptotic Pathways in Synovial Fibroblasts36	8.0	IGF1, IL6, BDNF, BMP2, AKT1, TP53
32	PEDF Induced Signaling36	8.0	LTA, TNF, HRAS, FOS, SOD2, AKT1
33	DHA Signaling36	8.0	NTRK1, BDNF, BCL2, AKT1, IL6, APP
34	Activation of PKC through GPCR36	7.9	TGFA, ADCY1, TGM2, MAPK1, BDNF, IL6
35	NFAT in Immune Response36	7.9	NTRK1, TGFA, LYN, EPOR, AKT1, IGF1
36	Cellular Apoptosis Pathway36	7.8	ATM, BCL2, BDNF, BMP2, TGFA, IL6
37	NFAT and Cardiac Hypertrophy36	7.7	HRAS, MAP3K13, ADCY1, SRC, IL6, AKT1
38	Activation of PKA through GPCR36	7.6	MAPK1, PDE3B, BMP2, BDNF, ADCY1, IGF2
39	Molecular Mechanisms of Cancer36	7.6	EPOR, ADCY1, BMP2, RARA, AKT1, IGF2
40	MAPK Family Pathway36	7.5	TNF, HRAS, IGF1, BDNF, BMP2, IGF2
41	Rho Family GTPases36	7.5	BMP2, BDNF, BCL2, FOS, EPOR, TGFA
42	Intracellular Calcium Signaling36	7.5	CREB1, IGF2, IGF1, CACNA1B, HRAS, SRC
43	JAK-STAT Pathway36	7.4	BMP2, BDNF, FOS, IL6, MAPK1, AKT1
44	GPCR Pathway36	7.3	STAT5A, IGF1, AKT1, HRAS, NTRK1, CREB1
45	Phospholipase-C Pathway36	7.3	SRC, NTRK1, CREB1, TGM2, LYN, ADCY1
46	Estrogen Pathway36	7.2	AKT1, SRC, NTRK1, CREB1, TGFA, EPOR
47	cAMP Pathway36	7.1	MAPK1, IL6, BDNF, BMP2, PDE3B, IGF2
48	Pancreatic Adenocarcinoma36	7.1	CCNB1, BDNF, BCL2, IL6, BMP2, MAPK1
49	p38 Signaling36	7.0	LTA, TGFA, BCL2, EPOR, MAP3K10, CREB1
50	MAPK Signaling36	6.3	EPOR, ADCY1, STAT5A, TGFA, LTA, CREB1

Compounds related to differentiating neuroblastoma according to GeneDecks:

(show top 50)    (show all 343)

id	Compound	Score	Top Affiliating Genes
1	carbachol32 9 9	12.0	HSPG2, CACNA1B, SNCA, HCRT, KNG1
2	glucose32	9.9	CDK5, APEX1, IGF2, HSPA9, TUBA1B, PDYN
3	gnrh32	9.6	IGF1, GNAS, HSPG2, AKT1, NTRK1, CREB1
4	epinephrine32 9 18 9	12.1	VTN, BDNF, CHGA, APP, CACNA1B, DUSP19
5	etoposide32 42 9 9	12.0	MYCN, RARA, BCL2, CHGA, ATM, CCNB1
6	pge232	8.7	PDE3B, VTN, BMP2, IGFBP5, GNAS, HSPG2
7	phosphotyrosine32	8.5	RET, BCAR1, FOS, MAPK1, IGF2, HRAS
8	cyclic amp32 18	9.5	PDE3B, RET, BDNF, CHGA, FOS, CCND3
9	okadaic acid32 42	9.3	PDE3B, BCAR1, BCL2, ATM, CDK5, FOS
10	cyclosporin a32 42	9.2	MYBL2, BMP2, APP, MAPT, HRAS, HMGB1
11	creatinine32	8.2	BMP2, BDNF, CHGA, APP, MAPT, IGF1
12	forskolin32 42 9 9	11.1	PDE3B, BMP2, BDNF, CHGA, FOS, MAPK1
13	ribonucleic acid32	8.1	RET, BMP2, RARA, CHGA, FOS, IGFBP5
14	histamine32 18	9.0	PDE3B, BDNF, CHGA, IGF2, HSPG2, AKT1
15	paraffin32	7.9	RET, MYCN, RARA, BCL2, CHGA, ATM
16	doxorubicin32 34 9 9	10.8	MYCN, BDNF, ATM, FOXO3, MAPT, CCNB1
17	cysteine32	7.8	VTN, RARA, APEX1, MAPT, IGF2, IFNG
18	6-hydroxydopamine32	7.8	BDNF, CDK5, FOS, APP, DRD3, SNCA
19	oxygen32 18	8.6	BMP2, BDNF, KDM1A, BCAR1, BCL2, ATM
20	rapamycin32 42	8.6	BMP2, BDNF, CDK5, FOXO3, CCNB1, CCND3
21	atp32	7.5	PDE3B, RET, VTN, BDNF, ATM, CDK5
22	nitric oxide32 9 18 9	10.5	PDE3B, MYCN, BMP2, CHGA, FOXO3, IL6
23	cholesterol32 9 18 9	10.5	PDE3B, VTN, BMP2, BDNF, CHGA, IL6
24	estrogen32	7.4	BMP2, RARA, BIN1, BDNF, BCAR1, CHGA
25	dopamine32 9 18 9	10.4	PDE3B, RET, MYCN, BMP2, BDNF, CDK5
26	ly29400232	7.4	RET, VTN, RARA, BCAR1, FOS, IL6
27	alanine32	7.3	RET, VTN, BMP2, RARA, FOXO3, IL6
28	phosphoinositide32	7.3	PDE3B, RARA, BDNF, BCAR1, ATM, FOS
29	acetylcholine32 9 18 9	10.0	BDNF, CHGA, APP, MAPT, HSPG2, CACNA1B
30	sb 20358032 42	7.9	BMP2, BCL2, FOS, IL6, CCNB1, IGF1
31	testosterone32 9 18 9	9.9	RET, BMP2, RARA, BDNF, KDM1A, CHGA
32	nmda32 42	7.9	BDNF, CDK5, FOS, APP, MAPT, MAPK1
33	paclitaxel32 34 9 9	9.8	RARA, BDNF, BCL2, CHGA, CDK5, APP
34	calcium32 9 18 9	9.8	PDE3B, VTN, BMP2, RARA, BDNF, BCAR1
35	glutamine32	6.7	VTN, ATM, CDK5, APP, MAPT, IGF2
36	glutamate32	6.7	VTN, CDK5, FOS, APEX1, APP, MAPT
37	cisplatin32 34 9 9	9.7	VTN, MYCN, BDNF, BCL2, CHGA, ATM
38	arginine32	6.6	RET, VTN, BMP2, RARA, CHGA, CDK5
39	curcumin32	6.6	VTN, BCL2, FOS, IL6, APP, MAPK1
40	adenylate32	6.6	PDE3B, BDNF, CHGA, FOS, APEX1, APP
41	butyrate32	6.5	RET, RARA, BCL2, FOS, APP, MAPT
42	calcitriol32 42 9 18 9	10.2	BMP2, RARA, CDK5, FOS, IL6, IGFBP5
43	norepinephrine32 9 18 9	9.2	BDNF, CHGA, IL6, APP, IGF2, GNAS
44	phosphatidylinositol32	6.0	PDE3B, RET, VTN, RARA, BDNF, BCAR1
45	indomethacin32 9 9	7.7	BMP2, BDNF, IL6, IGF2, IFNG, HSPG2
46	actinomycin d32	5.6	MYCN, BMP2, RARA, BDNF, BCL2, FOS
47	lipid32	5.5	PDE3B, RET, VTN, BMP2, RARA, BDNF
48	genistein32 9 18 9	7.8	RET, MYCN, BMP2, BCAR1, BCL2, ATM
49	retinoic acid32 42 18	6.6	RET, VTN, MYCN, MYBL2, BMP2, RARA
50	dexamethasone32 42 34 9 9	8.0	VTN, BMP2, RARA, BCL2, CHGA, FOS

Cellular components related to differentiating neuroblastoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nuclear chromatin	GO:000790	9.9	RXRA, TP53, KDM1A, RARA, SIRT1
2	cell surface	GO:009986	9.4	ADAM17, TGFA, NRD1, NTRK1, TNF, HMGB1
3	nucleoplasm	GO:005654	8.7	TP53, CREB1, RXRA, RPS27A, COIL, TFDP1
4	extracellular space	GO:005615	6.6	NGF, LTA, THBS1, TGFA, SOD1, KNG1
5	cytoplasm	GO:005737	6.1	ACP1, KRT20, NOS1, SNCA, TP53, HMGB1
6	extracellular region	GO:005576	5.7	VTN, NGF, NGRN, PDYN, HCRT, AGER
7	cytosol	GO:005829	5.5	NRD1, SNCA, NOS1, RPS27A, SHC3, TH
8	nucleus	GO:005634	5.5	NGRN, COIL, RXRA, CREB1, SNCA, SRC

Biological processes related to differentiating neuroblastoma according to GeneDecks:

(show top 50)    (show all 62)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPKK activity	GO:000186	10.6	MAP3K13, NTRK1
2	regulation of transcription from RNA polymerase II promoter	GO:006357	10.3	SOD2, STAT5A, TFDP1, HMGB1, IKBKAP, FOS
3	positive regulation of cell migration	GO:030335	10.2	ADAM17, LYN, THBS1, IKBKAP, BCAR1, BMP2
4	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	10.0	RET, NTRK1, NGF, SHC3, LYN
5	T cell differentiation in thymus	GO:033077	10.0	BCL2, TP53, STAT5A, ADAM17
6	phosphatidylinositol-mediated signaling	GO:048015	9.9	NGF, CREB1, NTRK1, AKT1, IGF1, FOXO3
7	MAPK cascade	GO:000165	9.9	POU4F2, TGFA, TNF, HRAS, MAPK1, RET
8	positive regulation of mitosis	GO:045840	9.8	TGFA, DRD3, TNF, IGF1, IGF2
9	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.8	ADAM17, LYN, PRL, STAT5A, MAPK1
10	response to ethanol	GO:045471	9.7	SOD1, STAT5A, TH, RXRA, DRD3, BCL2
11	positive regulation of protein kinase B signaling cascade	GO:051897	9.7	THBS1, TNF, IGF1, IGF2, IGFBP5
12	insulin receptor signaling pathway	GO:008286	9.7	SHC3, AKT1, HRAS, IGF2, MAPK1, BCAR1
13	response to hypoxia	GO:001666	9.5	ADAM17, THBS1, TH, LTA, NOS1, TNF
14	positive regulation of protein phosphorylation	GO:001934	9.5	ADAM17, SIRT1, TNF, AKT1, HRAS, IGF2
15	activation of MAPK activity	GO:000187	9.5	SOD1, TGFA, THBS1, RPS27A, TNF, MAPK1
16	negative regulation of neuron apoptotic process	GO:043524	9.4	SOD2, SOD1, TGFA, NGF, SNCA, NTRK1
17	positive regulation of neuron differentiation	GO:045666	9.4	EPO, IFNG, ASCL1, BDNF, BMP2
18	neuron apoptotic process	GO:051402	9.4	TP53, APP, CDK5, ATM, BCL2
19	protein import into nucleus, translocation	GO:000060	9.4	IFNG, AKT1, TP53, TNF
20	protein autophosphorylation	GO:046777	9.3	LYN, NTRK1, AKT1, MAP3K10, MAP3K13, CDK5
21	platelet degranulation	GO:002576	9.3	KNG1, LYN, SOD1, THBS1, IGF1, APP
22	fibroblast growth factor receptor signaling pathway	GO:008543	9.2	ADCY1, RPS27A, CREB1, SRC, AKT1, HRAS
23	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.2	SIRT1, POU4F2, RPS27A, RXRA, DRD3, TNF
24	synaptic transmission	GO:007268	9.2	ADCY1, HCRTR1, HCRT, ACP1, PDYN, CREB1
25	regulation of multicellular organism growth	GO:040014	9.1	SOD1, PRL, STAT5A, DRD3, IGF1, APP
26	cell aging	GO:007569	9.1	SIRT1, SOD1, TP53, BCL2
27	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.1	SNCA, TNF, AKT1, IL6, BCL2
28	peptidyl-serine phosphorylation	GO:018105	9.0	EPO, AKT1, MAPK1, MAP3K10, CDK5, ATM
29	positive regulation of apoptotic process	GO:043065	9.0	ADCY10, KNG1, SIRT1, SOD1, RXRA, TNF
30	epidermal growth factor receptor signaling pathway	GO:007173	9.0	ADAM17, ADCY1, TGFA, SHC3, RPS27A, CREB1
31	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	AGER, RPS27A, NTRK1, TNF, MAP3K13, IL6
32	Ras protein signal transduction	GO:007265	9.0	SHC3, NGF, NTRK1, SRC, TP53, HRAS
33	nerve growth factor receptor signaling pathway	GO:048011	9.0	ADAM17, ADCY1, SHC3, NGF, RPS27A, CREB1
34	neuron projection development	GO:031175	8.9	LYN, AGER, NGF, HMGB1, APP, IL6
35	humoral immune response	GO:006959	8.9	LTA, TNF, IFNG, IL6, BCL2
36	positive regulation of MAPK cascade	GO:043410	8.7	DUSP19, HRAS, IGF1, IGF2, IL6
37	cell proliferation	GO:008283	8.7	PRL, TFDP1, TGFA, NRD1, TP53, AKT1
38	inflammatory response	GO:006954	8.7	KNG1, AGER, NGF, RXRA, TNF, AKT1
39	regulation of apoptotic process	GO:042981	8.6	SIRT1, LYN, RPS27A, CREB1, TP53, IL6
40	positive regulation of cell proliferation	GO:008284	8.3	LYN, SIRT1, ADAM17, EPO, NGF, DRD3
41	response to drug	GO:042493	8.3	THBS1, TGFA, SOD1, LYN, ADCY1, ADAM17
42	anti-apoptosis	GO:006916	8.3	NGF, THBS1, TGFA, SOD1, ADAM17, EPO
43	negative regulation of cell proliferation	GO:008285	8.2	LYN, SOD2, RXRA, NTRK1, TNF, TP53
44	negative regulation of apoptotic process	GO:043066	8.1	TNF, THBS1, SOD2, SIRT1, EPO, TP53
45	apoptotic process	GO:006915	8.0	EPO, TFPT, KRT20, NGF, RPS27A, TNF
46	positive regulation of transcription, DNA-dependent	GO:045893	7.9	EPO, CREB1, TNF, RET, BMP2, RARA
47	signal transduction	GO:007165	7.7	SRC, CREB1, LTA, LYN, ADCY1, EPO
48	platelet activation	GO:030168	7.3	KNG1, LYN, SOD1, THBS1, SRC, AKT1
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	MYCN, TNF, DRD3, CREB1, NOS1, RXRA
50	blood coagulation	GO:007596	6.8	TP53, SRC, NOS1, THBS1, SOD1, LYN

Molecular functions related to differentiating neuroblastoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integrin binding	GO:005178	8.8	ADAM17, LYN, THBS1, SRC, IGF1, VTN
2	growth factor activity	GO:008083	8.7	NGF, IGF1, IGF2, IL6, BDNF, BMP2
3	identical protein binding	GO:042802	8.4	EPOR, SIRT1, SYP, THBS1, COIL, SNCA
4	protein binding	GO:005515	2.3	EPOR, COIL, RXRA, NOS1, CREB1, SNCA