MCID: DFF012
MIFTS: 36

Differentiating Neuroblastoma malady

Cancer diseases, Neuronal diseases categories

Summaries for Differentiating Neuroblastoma

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34MalaCards
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MalaCards: Differentiating Neuroblastoma is related to neuroendocrine tumor and adenoma. An important gene associated with Differentiating Neuroblastoma is ASCL1 (achaete-scute family bHLH transcription factor 1), and among its related pathways are Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) and LPA receptor mediated events. The compounds valproate and dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are craniofacial and integument.

Aliases & Classifications for Differentiating Neuroblastoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

differentiating neuroblastoma 9 11 63


External Ids:

Disease Ontology9 DOID:4160
NCIt41 C42048

Related Diseases for Differentiating Neuroblastoma

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18GeneCards, 19GeneDecks
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Diseases related to Differentiating Neuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine tumor30.1PRL
2adenoma29.9ASCL1, PRL, SRC, KRT20
3neuroblastoma10.9
4neuroendocrine carcinoma10.0ASCL1, KRT20
5spinal muscular atrophy10.0SMN1, COIL
6muscular atrophy10.0COIL, SMN1
7papilloma10.0KRT20, SRC, POU4F2
8neuronitis10.0
9alzheimer's disease10.0
10hypoglycemia10.0
11merkel cell carcinoma10.0
12central neurocytoma10.0
13mediastinitis10.0
14pheochromocytoma10.0
15dysautonomia10.0
16hypoxia10.0
17lung small cell carcinoma10.0KRT20, SRC, ASCL1
18colon cancer10.0KRT20, BCAR1, SRC
19lung cancer9.9KRT20, SRC, ASCL1

Graphical network of diseases related to Differentiating Neuroblastoma:



Diseases related to differentiating neuroblastoma

Symptoms for Differentiating Neuroblastoma

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Drugs & Therapeutics for Differentiating Neuroblastoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Differentiating Neuroblastoma

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Genetic Tests for Differentiating Neuroblastoma

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Anatomical Context for Differentiating Neuroblastoma

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34MalaCards
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MalaCards organs/tissues related to Differentiating Neuroblastoma:

34
Brain, Testes, Pituitary

Animal Models for Differentiating Neuroblastoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.1IKBKAP, ASCL1, SMN1, SRC
2MP:00107718.9SMN1, ASCL1, PRL, SRC, IKBKAP
3MP:00053918.8IKBKAP, ASCL1, POU4F2, SRC
4MP:00053868.5IKBKAP, SRC, PRL, ASCL1, POU4F2, SMN1
5MP:00053698.4SMN1, MAP3K10, BCAR1, IKBKAP
6MP:00053808.0BCAR1, MAP3K10, IKBKAP, SRC, SMN1
7MP:00036318.0MAP3K10, IKBKAP, SRC, PRL, ASCL1, SMN1
8MP:00053847.6COIL, SRC, IKBKAP, POU4F2, BCAR1, SMN1
9MP:00107687.3SMN1, ASCL1, SRC, IKBKAP, COIL, BCAR1

Publications for Differentiating Neuroblastoma

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53PubMed
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Articles related to Differentiating Neuroblastoma:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. (21559466)
2011
2
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. (19318809)
2009
3
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. (19647006)
2009
4
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. (19223552)
2009
5
Isoflurane attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in differentiated neuroblastoma SH-SY5Y cells. (19032555)
2009
6
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. (19726241)
2009
7
Differentiating neuroblastoma arising in mediastinal germ cell tumour. (18631196)
2008
8
Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line. (17559250)
2007
9
A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. (17045782)
2007
10
Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. (17490655)
2007
11
The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells. (17050705)
2006
12
Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells. (15079871)
2004
13
Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells. (14515147)
2003
14
Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells. (13130517)
2003
15
Arachidonate release and c-fos expression in various models of hypoxia and hypoxia-hypoglycemia in retinoic acid differentiated neuroblastoma cells. (11741009)
2002
16
Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. (11738505)
2001
17
Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. (11606272)
2001
18
Relative sensitivity of undifferentiated and cyclic adenosine 3',5'-monophosphate-induced differentiated neuroblastoma cells to cyclosporin A: potential role of beta-amyloid and ubiquitin in neurotoxicity. (10718363)
2000
19
A mathematical model for assessing changes in neurofilament protein levels in neurites and cell bodies of differentiating neuroblastoma cells. (10873435)
2000
20
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. (10080936)
1999
21
Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. (9442079)
1998
22
Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid. (9557945)
1998
23
Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. (9016955)
1997
24
Detection of delta opioid receptor and N-methyl-D-aspartate receptor-like immunoreactivity in retinoic acid-differentiated neuroblastoma x glioma (NG108-15) cells. (8981241)
1997
25
Size changes in differentiating neuroblastoma cells. (9466674)
1997
26
Nimodipine and nitrendipine inhibit N-type calcium channels in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid (NG 108-15) cells. (9259470)
1997
27
Colocalisation of CTP:choline phosphate cytidylyltransferase (CT) with F-actin accompanies increased phosphatidylcholine synthesis in differentiating neuroblastoma cells. (9450022)
1997
28
Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report. (8893739)
1996
29
Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. (18627021)
1996
30
Production and function of lipid second messengers in proliferating and differentiated neuroblastoma cells. (8906581)
1996
31
The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. (8657106)
1996
32
Biochemical evidence for a mature phenotype in morphologically poorly differentiated neuroblastomas with a favourable outcome. (7576941)
1995
33
Induction of apoptotic cell death in differentiating neuroblastoma SH-SY5Y cells by colchicine. (8135827)
1994
34
Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells. (7911712)
1994
35
Radiation therapy of well-differentiated neuroblastoma and central neurocytoma. (8339224)
1993
36
Temporal expression of neurofilament polypeptides in differentiating neuroblastoma cells. (1662992)
1991
37
A lead-associated nuclear protein which increases in maturing brain and in differentiating neuroblastoma 2A cells exposed to cyclic AMP-elevating agents. (1708708)
1990
38
Retinoic acid induced differentiated neuroblastoma cells show increased expression of the beta A4 amyloid gene of Alzheimer's disease and an altered splicing pattern. (2205513)
1990
39
Cyclic AMP-dependent expression of the heavy neurofilament (NF-H) polypeptide in differentiating neuroblastoma cells. (2160043)
1990
40
A short-term screening test for teratogens using differentiating neuroblastoma cells in vitro. (6740511)
1984
41
Ultrastructural changes in differentiating neuroblastoma x glioma hybrid cells. (6320493)
1983
42
DNA synthesis in differentiating neuroblastoma cells following induction by glioma cells. (7083276)
1982
43
Tubulin pools in differentiating neuroblastoma cells. (7251659)
1981
44
Lateral diffusion of membrane D-galactosyl glycoconjugates of differentiating neuroblastoma cells. (7332554)
1981
45
A pigmented differentiating neuroblastoma: a light and ultrastructural study. (7397624)
1980
46
Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells. (508746)
1979
47
Specific alterations in phosphorylation of cytosol proteins from differentiating neuroblastoma cells grown in culture. (189207)
1977
48
Increased rate of acetylcholinesterase synthesis in differentiating neuroblastoma cells. (4548065)
1974
49
Rates of oxygen uptake in proliferating and differentiating neuroblastoma cells. (5025651)
1972
50
A differentiating neuroblastoma. (5843953)
1965

Variations for Differentiating Neuroblastoma

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Expression for genes affiliated with Differentiating Neuroblastoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Differentiating Neuroblastoma

Search GEO for disease gene expression data for Differentiating Neuroblastoma.

Pathways for genes affiliated with Differentiating Neuroblastoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 54QIAGEN
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Pathways related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3BCAR1, SRC
29.3BCAR1, SRC
3
Show member pathways
9.3BCAR1, SRC
49.3BCAR1, SRC
59.3BCAR1, SRC
69.3BCAR1, SRC
79.3BCAR1, SRC
89.3SRC, BCAR1
99.3SRC, BCAR1
109.3SRC, BCAR1
11
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b739
a4b1 and a4b7 Integrin signaling39
9.3SRC, BCAR1
129.3SRC, BCAR1
139.3SRC, BCAR1
149.3SRC, BCAR1
15
Show member pathways
9.1SRC, MAP3K10, PRL
168.9PRL, SRC, BCAR1

Compounds for genes affiliated with Differentiating Neuroblastoma

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB
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Compounds related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1valproate469.7PRL, SMN1
2dopamine46 30 25 1212.5ASCL1, PRL, SRC
3k252a469.5BCAR1, SRC
4ribonucleic acid469.4PRL, KRT20, SMN1
5tamoxifen46 52 30 1212.0BCAR1, SRC, PRL
6threonine468.5SRC, IKBKAP, BCAR1, MAP3K10
7proline468.4SRC, BCAR1, MAP3K10
8estrogen468.2BCAR1, POU4F2, PRL, KRT20, SRC
9tyrosine468.2KRT20, SMN1, BCAR1, SRC, ASCL1
10serine468.0MAP3K10, COIL, IKBKAP, SRC, BCAR1

GO Terms for genes affiliated with Differentiating Neuroblastoma

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17Gene Ontology
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Molecular functions related to Differentiating Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:0434259.3MAP3K10, ASCL1
2protein bindingGO:0055157.3KRT20, BCAR1, COIL, IKBKAP, SRC, PRL

Products for genes affiliated with Differentiating Neuroblastoma

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Sources for Differentiating Neuroblastoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet