MCID: DFF016
MIFTS: 41

Diffuse Astrocytoma malady

Neuronal, Cancer categories

Summaries for Diffuse Astrocytoma

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33MalaCards
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MalaCards: Diffuse Astrocytoma, also known as gemistocytic astrocytoma, is related to astrocytoma and pilocytic astrocytoma. An important gene associated with Diffuse Astrocytoma is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are Angiogenesis and Cyclins and Cell Cycle Regulation. The compounds matrigel and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include cortex, spinal cord and t cells, and related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Diffuse Astrocytoma

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

diffuse astrocytoma 43 49 61
gemistocytic astrocytoma 43 61
protoplasmic astrocytoma 43 61
fibrillary astrocytoma 43 61
low-grade diffuse astrocytoma 43


Related Diseases for Diffuse Astrocytoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Diffuse Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.1CENPF, IFNB1, IDH1, TIMP3, TNC, MGMT
2pilocytic astrocytoma30.5TIMP3, IDH1, TNC, MGMT, SYP, CDK4
3gliosarcoma30.2CDK4
4anaplastic oligodendroglioma30.0LGALS3, CDK4, CDKN2B, CDKN2A, IGFBP2, MGMT
5anaplastic astrocytoma30.0DMBT1, MGMT, TNC, IGFBP2, CDKN2A, CDKN2B
6gemistocytic astrocytoma10.9
7protoplasmic astrocytoma10.7
8papillary carcinoma10.2
9subependymal giant cell astrocytoma10.2
10spinal cord astrocytoma10.2
11giant cell glioblastoma10.2
12vasculitis10.2
13tuberous sclerosis10.1
14solitary fibrous tumor10.1
15fibrillary astrocytoma10.0
16hemorrhage, intracerebral10.0
17neuroblastoma10.0SYP
18paraganglioma10.0SYP
19hemangioma10.0PECAM1
20lichen planus10.0PECAM1
21peritonitis10.0PECAM1
22parathyroid adenoma10.0LGALS3
23diabetic retinopathy10.0TIMP3
24pituitary tumors10.0LGALS3
25rhabdomyosarcoma10.0CDK4
26myelodysplastic syndromes10.0CDKN2B
27acute leukemia10.0CDKN2B, IGFBP2
28sarcoma10.0CDK4, PECAM1
29arthritis10.0PECAM1, TIMP3
30myeloma10.0CDKN2B, TIMP3
31multiple myeloma10.0CDKN2A
32diabetes mellitus10.0PECAM1, IGFBP2
33myeloid leukemia10.0CDKN2B, CDK4
34brain cancer10.0SYP, IDH1
35obesity10.0IGFBP2, EDNRA
36merkel cell carcinoma10.0SYP
37cholangiocarcinoma10.0TIMP3, LGALS3
38esophageal cancer10.0CDKN2A
39pulmonary fibrosis10.0TNC, EDNRA
40chondrosarcoma10.0CDK4, TNC
41chordoma10.0LGALS3
42hypertension10.0ECE1, EDNRA
43tuberculosis10.0NME4, IFNB1
44hepatitis c10.0IFNB1, TIMP3
45thyroid cancer10.0LGALS3, TNC, TIMP3
46papilloma10.0CDKN2B, CDKN2A
47neurofibroma10.0TNC, SYP
48amyotrophic lateral sclerosis10.0IGFBP2, SYP
49central nervous system lymphoma, primary10.0TIMP3, MGMT
50pneumonia10.0EDNRA

Graphical network of the top 20 diseases related to Diffuse Astrocytoma:



Diseases related to diffuse astrocytoma

Clinical Features for Diffuse Astrocytoma

Drugs & Therapeutics for Diffuse Astrocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Diffuse Astrocytoma

Search NIH Clinical Center for Diffuse Astrocytoma

Search CenterWatch for Diffuse Astrocytoma

Genetic Tests for Diffuse Astrocytoma

Anatomical Context for Diffuse Astrocytoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Diffuse Astrocytoma:

33
Cortex, Spinal cord, T cells, B cells, Endothelial

Animal Models for Diffuse Astrocytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Diffuse Astrocytoma

Sources:
51PubMed
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Articles related to Diffuse Astrocytoma:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Diffuse Astrocytoma Initially Presenting as a Massive Intracerebral Hemorrhage: Case Report. (24418786)
2014
2
H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas. (23429371)
2013
3
MET gain in diffuse astrocytomas is associated with poorer outcome. (22672415)
2013
4
DNA Repair Gene XRCC4 Codon 247 Polymorphism Modified Diffusely Infiltrating Astrocytoma Risk and Prognosis. (24378850)
2013
5
BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern. (22710963)
2012
6
IDH1 mutations in diffusely infiltrating astrocytomas: grade specificity, association with protein expression, and clinical relevance. (22904127)
2012
7
Diffuse pontine astrocytoma with lipocytic differentiation. (23049461)
2012
8
DMBT1 homozygous deletion in diffuse astrocytomas is associated with unfavorable clinical outcome. (22805772)
2012
9
Clinicopathological features in the recurrence of oligodendroglioma and diffuse astrocytoma. (22648019)
2012
10
A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53. (21343879)
2011
11
Delayed intracerebral radiation necrosis occurring a decade after conventional radiotherapy in a patient of diffuse astrocytoma. (21768679)
2011
12
Expression and prognostic significance of survivin splice variants in diffusely infiltrating astrocytoma. (21730264)
2011
13
Mitochondrial DNA depletion and its correlation with TFAM, TFB1M, TFB2M and POLG in human diffusely infiltrating astrocytomas. (20643228)
2011
14
Focal cortical dysplasia coexisting with diffuse astrocytoma in childhood: a case report and reappraisal of the glial component in archival FCD cases. (21118400)
2011
15
High frequency of IDH-1 mutation links glioneuronal tumors with neuropil-like islands to diffuse astrocytomas. (21755347)
2011
16
Factors predicting progression of low-grade diffusely infiltrating astrocytoma. (21483127)
2011
17
Diffuse central nervous system protoplasmic astrocytoma. (20049933)
2010
18
Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis. (20044756)
2010
19
Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma. (19543740)
2009
20
ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. (19306055)
2009
21
Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach. (17965865)
2008
22
Association of EGFR c.2073A>T polymorphism with decreased risk of diffusely infiltrating astrocytoma in a Brazilian case-control study. (18949739)
2008
23
Utility of EGFR and PTEN numerical aberrations in the evaluation of diffusely infiltrating astrocytomas. Laboratory investigation. (18240930)
2008
24
Congenital diffuse anaplastic astrocytoma with ependymal and leptomeningeal spread: case report. (17443288)
2007
25
Prognostic significance of loss of O6-methylguanine-DNA methyltransferase expression in supratentorial diffuse low-grade astrocytoma. (17825378)
2007
26
Association of TP53 mutation, p53 overexpression, and p53 codon 72 polymorphism with susceptibility to apoptosis in adult patients with diffuse astrocytomas. (16711514)
2006
27
Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles. (16896313)
2006
28
Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma. (16203285)
2005
29
Detection of somatic TP53 splice site mutations in diffuse astrocytomas. (15914282)
2005
30
Localization of the endothelin system in human diffuse astrocytomas. (16007684)
2005
31
Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. (16003541)
2005
32
Therapeutic implications of interferon regulatory factor (IRF)-1 and IRF-2 in diffusely infiltrating astrocytomas (DIA): response to interferon (IFN)-beta in glioblastoma cells and prognostic value for DIA. (16187022)
2005
33
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. (15118874)
2004
34
Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)
2004
35
Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. (14581362)
2003
36
Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas. (12744471)
2003
37
Morphological changes and stress responses in neurons in cerebral cortex infiltrated by diffuse astrocytoma. (14719540)
2003
38
Treatment of low-grade diffuse astrocytomas by surgery and human fibroblast interferon without radiation therapy. (12622456)
2003
39
A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas. (14570288)
2003
40
Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas. (11907807)
2002
41
PTEN, DMBT1, and p16 alterations in diffusely infiltrating astrocytomas. (12168116)
2002
42
Microtubule-associated protein 2 (MAP-2) is expressed in low and high grade diffuse astrocytomas. (11922706)
2002
43
Mitosin and DNA topoisomerase IIalpha: two novel proliferation markers in the prognostication of diffuse astrocytoma patient survival. (11556747)
2001
44
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
45
Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays. (11156382)
2000
46
Insulin-like growth factor-1 content and pattern of expression correlates with histopathologic grade in diffusely infiltrating astrocytomas. (11550306)
1999
47
Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma. (1902506)
1991
48
Correlation of computed tomography and postmortem findings of a diffuse astrocytoma: a case report. (2598161)
1989
49
Diffuse leptomeningeal seeding from a malignant spinal cord astrocytoma in a child with neurofibromatosis. (3023559)
1986
50
Prognosis of the so-called "diffuse" cerebellar astrocytoma. (6483145)
1984

Genetic Variations for Diffuse Astrocytoma

Expression for genes affiliated with Diffuse Astrocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diffuse Astrocytoma

Search GEO for disease gene expression data for Diffuse Astrocytoma.

Pathways for genes affiliated with Diffuse Astrocytoma

Sources:
4Cell Signaling Technology, 52QIAGEN, 54Reactome, 38NCBI BioSystems Database
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Pathways related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1PECAM1, TNC, TIMP3
2
Hide members
10.0CDKN2A, CDKN2B, CDK4
310.0CDK4, CDKN2B, IFNB1
410.0CDK4, CDKN2A, MGMT

Compounds for genes affiliated with Diffuse Astrocytoma

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1matrigel4510.5PECAM1, EDNRA
2sialic acid4510.4PECAM1, DMBT1, IFNB1
3sodium bisulfite4510.4CDKN2B, CDKN2A, MGMT
4o6-methylguanine4510.3TIMP3, MGMT, CDKN2A, CDKN2B
5acnu4510.3CDKN2A, MGMT, IFNB1
65-methylcytosine45 2411.3CDKN2B, CDKN2A, MGMT
7fascaplysin4510.3CDKN2A, CDK4
8hematoxylin4510.3SYP, CDKN2A, LGALS3, PECAM1
9heparin45 29 11 2413.3PECAM1, IFNB1, TIMP3
10cycloheximide4510.3IGFBP2, IFNB1
11serine4510.2DMBT1, SYP, ECE1, CDKN2B, PECAM1
12deoxyribonucleic acid4510.2TIMP3, MGMT, IGFBP2, CDKN2A
13temozolomide45 1111.1CDKN2A, MGMT, IFNB1
14silver4510.1IFNB1, TNC, SYP, CDKN2A
15tgf beta14510.1TIMP3, IFNB1, TNC, CDKN2B, CDK4
16estradiol45 11 2412.1TIMP3, IFNB1, EDNRA, SYP, CDK4
175-aza-2deoxycytidine4510.0TIMP3, IFNB1, MGMT, CDKN2A, CDKN2B
18azathioprine45 50 2 1113.0IFNB1, MGMT, CDKN2A, CDKN2B
19p0024510.0IFNB1, TNC, MGMT, IGFBP2, PECAM1
20paclitaxel45 50 1112.0IFNB1, EDNRA, CDKN2A, CDK4, CENPF
21thymidylate459.9IFNB1, MGMT, CDKN2A, CDK4
22dexamethasone45 50 29 1112.9TIMP3, IFNB1, MGMT, EDNRA, CDKN2A, CDK4
23creatinine459.9IFNB1, EDNRA, SYP, CDKN2A, NME4
24glucose459.9TIMP3, MGMT, EDNRA, IGFBP2, ECE1, CDKN2A
25glycogen45 2410.9EDNRA, SYP, IGFBP2, CDK4, NME4, LGALS3
26genistein45 29 60 2 11 2414.9TIMP3, IFNB1, MGMT, SYP, CDKN2A, CDK4
27superoxide45 2410.8IFNB1, SYP, IGFBP2, CDK4, LGALS3, PECAM1
28formaldehyde45 2410.8TNC, MGMT, EDNRA, SYP, IGFBP2, LGALS3
29cisplatin45 50 60 1112.8IFNB1, MGMT, SYP, CDKN2A, CDK4, LGALS3
30steroid459.8TIMP3, EDNRA, SYP, IGFBP2, ECE1, CDKN2A
31acth459.8LGALS3, IGFBP2, SYP, IFNB1
32pd 98,059459.8CDK4, CDKN2B, ECE1, IFNB1, TIMP3
33thymidine45 2410.7IFNB1, MGMT, EDNRA, IGFBP2, CDK4, PECAM1
34h2o2459.7IFNB1, TNC, EDNRA, SYP, CDKN2A, LGALS3
35leucine459.7EDNRA, SYP, IGFBP2, CDKN2A, CDK4, CENPF
36nitric oxide45 11 2411.7MGMT, EDNRA, SYP, ECE1, CDKN2A, CDK4
37cholesterol45 29 11 2412.7IFNB1, EDNRA, SYP, IGFBP2, ECE1, CDKN2A
38ly294002459.6TIMP3, IFNB1, TNC, IGFBP2, CDK4
39paraffin459.6TIMP3, TNC, MGMT, EDNRA, SYP, CDKN2A
40oxygen45 2410.6TIMP3, EDNRA, IGFBP2, CDKN2A, CDK4, LGALS3
41testosterone45 60 11 2412.4TIMP3, EDNRA, SYP, IGFBP2, CDKN2A, CDK4
42progesterone45 60 29 11 2413.4TIMP3, IFNB1, TNC, MGMT, SYP, IGFBP2
43lipid459.4TIMP3, IFNB1, TNC, EDNRA, SYP, IGFBP2
44actinomycin d459.3IFNB1, TNC, ECE1, CDKN2A, PECAM1
45oligonucleotide459.3MGMT, TNC, IFNB1, TIMP3, EDNRA, IGFBP2
46retinoic acid45 2410.2TIMP3, IFNB1, TNC, MGMT, SYP, IGFBP2
47tyrosine459.2TIMP3, IFNB1, TNC, EDNRA, SYP, IGFBP2
48cysteine459.1EDNRA, MGMT, TNC, IFNB1, TIMP3, DMBT1
49vegf459.0PECAM1, TIMP3, IFNB1, TNC, MGMT, EDNRA
50calcium45 50 11 2411.7EDNRA, MGMT, TNC, IFNB1, IDH1, TIMP3

GO Terms for genes affiliated with Diffuse Astrocytoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of G2/M transition of mitotic cell cycleGO:01038910.0CENPF, CDKN2A
2positive regulation of epithelial cell differentiationGO:0308589.9CDKN2B, DMBT1
3response to drugGO:0424939.8CENPF, CDK4, IGFBP2, MGMT

Molecular functions related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:03240310.1BIN1, CDK4, SYP
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.9CDKN2B, CDKN2A
3protein bindingGO:0055158.4CENPF, RPL5, TIMP3, EDNRA, DMBT1, IGFBP2

Products for genes affiliated with Diffuse Astrocytoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diffuse Astrocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet