MCID: DFF016
MIFTS: 37

Diffuse Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Diffuse Astrocytoma

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32MalaCards
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MalaCards: Diffuse Astrocytoma, also known as protoplasmic astrocytoma, is related to astrocytoma and oligodendroglioma. An important gene associated with Diffuse Astrocytoma is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways are Angiogenesis and Cyclins and Cell Cycle Regulation. The compounds matrigel and sialic acid have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and muscle.

Aliases & Classifications for Diffuse Astrocytoma

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42NIH Rare Diseases, 60UMLS, 48Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

diffuse astrocytoma 42 48 60
protoplasmic astrocytoma 42 60
gemistocytic astrocytoma 42 60
fibrillary astrocytoma 42 60
low-grade diffuse astrocytoma 42


External Ids:

SNOMED-CT via Orphanet57 397381007

Related Diseases for Diffuse Astrocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Diffuse Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.1CENPF, IFNB1, IDH1, TIMP3, TNC, MGMT
2oligodendroglioma30.5MGMT, CDKN2A, CDKN2B
3fibrosarcoma30.2TIMP3, IFNB1, TNC
4gliosarcoma30.1CDK4
5retinoblastoma30.0SYP, IGFBP2, CDKN2A, CDKN2B, CDK4, CENPF
6gemistocytic astrocytoma10.8
7protoplasmic astrocytoma10.7
8papillary carcinoma10.2
9subependymal giant cell astrocytoma10.2
10spinal cord astrocytoma10.2
11giant cell glioblastoma10.2
12papillary thyroid carcinoma10.2
13thyroiditis10.2
14vasculitis10.2
15tuberous sclerosis10.1
16cerebritis10.0
17fibrillary astrocytoma10.0
18neuronitis10.0
19neuroblastoma10.0SYP
20paraganglioma10.0SYP
21hemangioma10.0PECAM1
22lichen planus10.0PECAM1
23peritonitis10.0PECAM1
24parathyroid adenoma10.0LGALS3
25diabetic retinopathy10.0TIMP3
26pituitary tumors10.0LGALS3
27rhabdomyosarcoma10.0CDK4
28myelodysplastic syndromes10.0CDKN2B
29acute leukemia10.0CDKN2B, IGFBP2
30sarcoma10.0CDK4, PECAM1
31arthritis10.0PECAM1, TIMP3
32myeloma10.0CDKN2B, TIMP3
33multiple myeloma10.0CDKN2A
34diabetes mellitus10.0PECAM1, IGFBP2
35myeloid leukemia10.0CDKN2B, CDK4
36obesity10.0IGFBP2, EDNRA
37brain cancer10.0SYP, IDH1
38merkel cell carcinoma10.0SYP
39cholangiocarcinoma10.0TIMP3, LGALS3
40esophageal cancer10.0CDKN2A
41pulmonary fibrosis10.0TNC, EDNRA
42chordoma10.0LGALS3
43chondrosarcoma10.0CDK4, TNC
44hypertension10.0ECE1, EDNRA
45tuberculosis10.0NME4, IFNB1
46hepatitis c10.0IFNB1, TIMP3
47thyroid cancer10.0LGALS3, TNC, TIMP3
48papilloma10.0CDKN2B, CDKN2A
49amyotrophic lateral sclerosis10.0IGFBP2, SYP
50neurofibroma10.0TNC, SYP

Graphical network of the top 20 diseases related to Diffuse Astrocytoma:



Diseases related to diffuse astrocytoma

Clinical Features for Diffuse Astrocytoma

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Drugs & Therapeutics for Diffuse Astrocytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Diffuse Astrocytoma

Genetic Tests for Diffuse Astrocytoma

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Anatomical Context for Diffuse Astrocytoma

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Animal Models for Diffuse Astrocytoma or affiliated genes

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36MGI
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Publications for Diffuse Astrocytoma

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Genetic Variations for Diffuse Astrocytoma

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Expression for genes affiliated with Diffuse Astrocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diffuse Astrocytoma

Search GEO for disease gene expression data for Diffuse Astrocytoma.

Pathways for genes affiliated with Diffuse Astrocytoma

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Sources:
4Cell Signaling Technology, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1PECAM1, TNC, TIMP3
2
Hide members
10.0CDKN2A, CDKN2B, CDK4
310.0CDK4, CDKN2B, IFNB1
410.0CDK4, CDKN2A, MGMT

Compounds for genes affiliated with Diffuse Astrocytoma

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1matrigel4410.5EDNRA, PECAM1
2sialic acid4410.4PECAM1, DMBT1, IFNB1
3sodium bisulfite4410.4CDKN2B, CDKN2A, MGMT
4o6-methylguanine4410.3CDKN2A, CDKN2B, MGMT, TIMP3
5acnu4410.3CDKN2A, MGMT, IFNB1
65-methylcytosine44 2411.3CDKN2A, CDKN2B, MGMT
7fascaplysin4410.3CDKN2A, CDK4
8hematoxylin4410.3CDKN2A, SYP, LGALS3, PECAM1
9heparin44 28 11 2413.3PECAM1, IFNB1, TIMP3
10cycloheximide4410.3IFNB1, IGFBP2
11serine4410.2ECE1, PECAM1, SYP, CDKN2B, DMBT1
12deoxyribonucleic acid4410.2TIMP3, MGMT, IGFBP2, CDKN2A
13temozolomide44 1111.1CDKN2A, IFNB1, MGMT
14silver4410.1SYP, CDKN2A, IFNB1, TNC
15tgf beta14410.1TIMP3, IFNB1, TNC, CDKN2B, CDK4
16estradiol44 11 2412.1TIMP3, IFNB1, EDNRA, CDK4, SYP
175-aza-2deoxycytidine4410.0TIMP3, MGMT, CDKN2A, CDKN2B, IFNB1
18azathioprine44 49 2 1113.0MGMT, IFNB1, CDKN2A, CDKN2B
19p0024410.0MGMT, TNC, IFNB1, PECAM1, IGFBP2
20paclitaxel44 49 1112.0CENPF, CDK4, CDKN2A, IFNB1, EDNRA
21thymidylate449.9MGMT, CDKN2A, CDK4, IFNB1
22dexamethasone44 49 28 1112.9TIMP3, MGMT, IFNB1, EDNRA, CDKN2A, CDK4
23creatinine449.9IFNB1, EDNRA, SYP, NME4, CDKN2A
24glucose449.9TIMP3, CDKN2A, ECE1, MGMT, EDNRA, IGFBP2
25glycogen44 2410.9LGALS3, NME4, CDK4, SYP, EDNRA, IGFBP2
26genistein44 28 59 2 11 2414.9CDK4, CDKN2A, MGMT, IFNB1, TIMP3, SYP
27superoxide44 2410.8LGALS3, IGFBP2, SYP, PECAM1, IFNB1, CDK4
28formaldehyde44 2410.8EDNRA, SYP, MGMT, LGALS3, PECAM1, TNC
29cisplatin44 49 59 1112.8CDK4, SYP, IFNB1, MGMT, CDKN2A, LGALS3
30steroid449.8IGFBP2, ECE1, CDK4, CDKN2A, SYP, TIMP3
31acth449.8LGALS3, SYP, IFNB1, IGFBP2
32pd 98,059449.8TIMP3, CDK4, CDKN2B, ECE1, IFNB1
33thymidine44 2410.7IFNB1, CDK4, PECAM1, IGFBP2, MGMT, EDNRA
34h2o2449.7IFNB1, TNC, EDNRA, SYP, PECAM1, CDKN2A
35leucine449.7CDK4, SYP, EDNRA, IGFBP2, CDKN2A, CENPF
36nitric oxide44 11 2411.7ECE1, LGALS3, MGMT, SYP, CDK4, EDNRA
37cholesterol44 28 11 2412.7IFNB1, SYP, IGFBP2, PECAM1, EDNRA, CDKN2A
38ly294002449.6TIMP3, TNC, CDK4, IFNB1, IGFBP2
39paraffin449.6TNC, SYP, EDNRA, MGMT, TIMP3, PECAM1
40oxygen44 2410.6IGFBP2, TIMP3, CDKN2A, PECAM1, LGALS3, CDK4
41testosterone44 59 11 2412.4IGFBP2, SYP, EDNRA, TIMP3, CDKN2A, CDK4
42progesterone44 59 28 11 2413.4TIMP3, IFNB1, TNC, MGMT, SYP, LGALS3
43lipid449.4PECAM1, IFNB1, EDNRA, CDKN2A, TNC, LGALS3
44actinomycin d449.3CDKN2A, ECE1, TNC, PECAM1, IFNB1
45oligonucleotide449.3TIMP3, IFNB1, TNC, MGMT, CDKN2A, CDK4
46retinoic acid44 2410.2LGALS3, CDK4, IGFBP2, CDKN2B, CDKN2A, SYP
47tyrosine449.2SYP, IGFBP2, CDK4, LGALS3, PECAM1, CENPF
48cysteine449.1CDK4, LGALS3, PECAM1, CDKN2A, ECE1, SYP
49vegf449.0ECE1, PECAM1, LGALS3, CDK4, CDKN2A, IGFBP2
50calcium44 49 11 2411.7PECAM1, TNC, MGMT, EDNRA, SYP, IGFBP2

GO Terms for genes affiliated with Diffuse Astrocytoma

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16Gene Ontology
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Biological processes related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of G2/M transition of mitotic cell cycleGO:01038910.0CENPF, CDKN2A
2positive regulation of epithelial cell differentiationGO:0308589.9CDKN2B, DMBT1
3response to drugGO:0424939.8CENPF, CDK4, IGFBP2, MGMT

Molecular functions related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:03240310.1BIN1, CDK4, SYP
2cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.9CDKN2B, CDKN2A
3protein bindingGO:0055158.4CDKN2A, DMBT1, IGFBP2, TIMP3, CDKN2B, CDK4

Products for genes affiliated with Diffuse Astrocytoma

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  • Antibodies
  • Proteins
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Sources for Diffuse Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet