MCID: DFF016
MIFTS: 35

Diffuse Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Diffuse Astrocytoma

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33MalaCards
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MalaCards: Diffuse Astrocytoma, also known as gemistocytic astrocytoma, is related to astrocytoma and oligodendroglioma. An important gene associated with Diffuse Astrocytoma is IDH1 (isocitrate dehydrogenase 1 (NADP+), soluble), and among its related pathways is Disease. The compounds p003 and sialic acid have been mentioned in the context of this disorder. Affiliated tissues include cortex, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Diffuse Astrocytoma

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43NIH Rare Diseases, 62UMLS, 49Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

diffuse astrocytoma 43 49 62
gemistocytic astrocytoma 43 62
protoplasmic astrocytoma 43 62
fibrillary astrocytoma 43 62
low-grade diffuse astrocytoma 43


External Ids:

SNOMED-CT via Orphanet59 397381007
UMLS via Orphanet63 C0280785

Related Diseases for Diffuse Astrocytoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Diffuse Astrocytoma:



Diseases related to diffuse astrocytoma

Symptoms for Diffuse Astrocytoma

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Drugs & Therapeutics for Diffuse Astrocytoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Diffuse Astrocytoma

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Anatomical Context for Diffuse Astrocytoma

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33MalaCards
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MalaCards organs/tissues related to Diffuse Astrocytoma:

33
Cortex

Animal Models for Diffuse Astrocytoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Diffuse Astrocytoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8DMBT1, BIN1, CDKN2B
2MP:00053678.5CDKN2B, DMBT1, PECAM1
3MP:00053847.8CDKN2B, BIN1, DMBT1, PECAM1
4MP:00053877.7CDKN2B, BIN1, IDH1, DMBT1, PECAM1
5MP:00053767.6PECAM1, DMBT1, IDH1, BIN1, CDKN2B

Publications for Diffuse Astrocytoma

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52PubMed
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Articles related to Diffuse Astrocytoma:

(show all 35)
idTitleAuthorsYear
1
Diffuse Astrocytoma Initially Presenting as a Massive Intracerebral Hemorrhage: Case Report. (24418786)
2014
2
MET gain in diffuse astrocytomas is associated with poorer outcome. (22672415)
2013
3
DMBT1 homozygous deletion in diffuse astrocytomas is associated with unfavorable clinical outcome. (22805772)
2012
4
Clinicopathological features in the recurrence of oligodendroglioma and diffuse astrocytoma. (22648019)
2012
5
A sensitive and specific diagnostic panel to distinguish diffuse astrocytoma from astrocytosis: chromosome 7 gain with mutant isocitrate dehydrogenase 1 and p53. (21343879)
2011
6
Delayed intracerebral radiation necrosis occurring a decade after conventional radiotherapy in a patient of diffuse astrocytoma. (21768679)
2011
7
Focal cortical dysplasia coexisting with diffuse astrocytoma in childhood: a case report and reappraisal of the glial component in archival FCD cases. (21118400)
2011
8
Discrimination between low-grade oligodendrogliomas and diffuse astrocytoma with the aid of 11C-methionine positron emission tomography. (21214332)
2011
9
High frequency of IDH-1 mutation links glioneuronal tumors with neuropil-like islands to diffuse astrocytomas. (21755347)
2011
10
Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis. (20044756)
2010
11
Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma. (19543740)
2009
12
Akt/protein kinase B overexpression as an accurate prognostic marker in adult diffuse astrocytoma. (19240976)
2009
13
ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. (19306055)
2009
14
Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach. (17965865)
2008
15
Tenascin-C expression relates to clinicopathological features in pilocytic and diffuse astrocytomas. (17983425)
2008
16
Association of TP53 mutation, p53 overexpression, and p53 codon 72 polymorphism with susceptibility to apoptosis in adult patients with diffuse astrocytomas. (16711514)
2006
17
Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles. (16896313)
2006
18
Detection of somatic TP53 splice site mutations in diffuse astrocytomas. (15914282)
2005
19
Localization of the endothelin system in human diffuse astrocytomas. (16007684)
2005
20
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. (15118874)
2004
21
Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)
2004
22
Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. (14581362)
2003
23
Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas. (12744471)
2003
24
Morphological changes and stress responses in neurons in cerebral cortex infiltrated by diffuse astrocytoma. (14719540)
2003
25
Treatment of low-grade diffuse astrocytomas by surgery and human fibroblast interferon without radiation therapy. (12622456)
2003
26
Evaluation of molecular markers in low-grade diffuse astrocytomas: loss of p16 and retinoblastoma protein expression is associated with short survival. (11914625)
2002
27
Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas. (11907807)
2002
28
Microtubule-associated protein 2 (MAP-2) is expressed in low and high grade diffuse astrocytomas. (11922706)
2002
29
Mitosin and DNA topoisomerase IIalpha: two novel proliferation markers in the prognostication of diffuse astrocytoma patient survival. (11556747)
2001
30
Differentiation between reactive gliosis and diffuse astrocytoma by in situ hybridization. (11342694)
2001
31
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
32
Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays. (11156382)
2000
33
Genetic heterogeneity and progression in different areas within high-grade diffuse astrocytoma. (10601603)
2000
34
Phase II study of ifosfamide with mesna in adult patients with recurrent diffuse astrocytoma. (1902506)
1991
35
Correlation of computed tomography and postmortem findings of a diffuse astrocytoma: a case report. (2598161)
1989

Variations for Diffuse Astrocytoma

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Expression for genes affiliated with Diffuse Astrocytoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diffuse Astrocytoma

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Pathways for genes affiliated with Diffuse Astrocytoma

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50PathCards, 55Reactome
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Pathways related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0CDKN2B, RPL5, IDH1

Compounds for genes affiliated with Diffuse Astrocytoma

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45Novoseek
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Compounds related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1p003459.0CDKN2B, PECAM1
2sialic acid458.7DMBT1, PECAM1
3estrogen458.7CDKN2B, BIN1, PECAM1

GO Terms for genes affiliated with Diffuse Astrocytoma

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16Gene Ontology
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Cellular components related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.9CDKN2B, BIN1, RPL5, IDH1, DMBT1
2extracellular vesicular exosomeGO:0700627.8RPL5, IDH1, DMBT1, PECAM1

Biological processes related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of epithelial cell differentiationGO:0308589.0CDKN2B, DMBT1
2viral processGO:0160328.9BIN1, RPL5, DMBT1

Molecular functions related to Diffuse Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5CDKN2B, BIN1, RPL5, DMBT1, PECAM1

Products for genes affiliated with Diffuse Astrocytoma

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Sources for Diffuse Astrocytoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet