MCID: DFF019
MIFTS: 42

Diffuse Gastric Cancer malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Diffuse Gastric Cancer

About this section
Sources:
42NIH Rare Diseases, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Diffuse gastric cancer is a type of cancer found most often in the glandular cells lining the stomach, but can also develop in the bowel, breast, pancreas, bladder, prostate or lung. the term "signet ring cell" is often used because the cells look like signet rings when viewed under a microscope. the signet cells are a type of epithelial cell. epithelial tissue is skin tissue, covering and lining the body both inside and out.  last updated: 12/16/2011

MalaCards: Diffuse Gastric Cancer, also known as signet ring cell gastric carcinoma, is related to hereditary diffuse gastric cancer and bladder carcinoma. An important gene associated with Diffuse Gastric Cancer is CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), and among its related pathways are Glioma and S-1P Stimulated Signaling. The compounds erlotinib and chi 2 have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and breast, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

Aliases & Classifications for Diffuse Gastric Cancer

About this section
Sources:
42NIH Rare Diseases, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

diffuse gastric cancer 42
signet ring cell gastric carcinoma 42
signet ring gastric carcinoma 42
carcinoma, signet ring cell 60
signet ring cell carcinoma 42
signet cell adenocarcinoma 42


Related Diseases for Diffuse Gastric Cancer

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Diffuse Gastric Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary diffuse gastric cancer31.6CDH1
2bladder carcinoma31.0CDH1, ERBB2, GSTT1
3lung adenocarcinoma30.5KLF6, PIK3CA, CDH1, KRAS, ERCC1, ERBB2
4breast cancer30.5PIK3CA, CDH1, KRAS, ERBB2
5basal cell carcinoma30.3XRCC3, CDH3, ERCC1, ERCC2, GSTT1
6adenoma30.3MTR, MUTYH, CDH1, CDH3, KRAS, ERCC1
7cleft lip30.3MTR
8gastric cancer risk after h. pylori infection30.3IL1B, IL1RN
9squamous cell carcinoma30.3ERBB2, ERCC1, KRAS, FGFR2, CDH3, CDH1
10cleft palate30.3MTR, FGFR2
11stomach cancer30.3CASP10, IRF1, MUTYH, KRAS
12peritonitis30.1IL1B
13pancreatitis30.1IL1B, KRAS, GSTP1
14gastric cancer, somatic30.1KLF6, CASP10, IRF1, PIK3CA, MUTYH, FGFR2
15pancreatic cancer30.1CDH3, FGFR2, IL1RN, KRAS, ERBB2, CDH1
16transitional cell carcinoma30.0CDH1, FGFR2, ERBB2, GSTT1, GSTP1
17gastric adenocarcinoma30.0PIK3CA, CDH1, CDH3, IL1RN, KRAS, ERBB2
18adenocarcinoma30.0KLF6, XRCC3, IRF1, PIK3CA, CDH1, CDH3
19signet ring cell adenocarcinoma10.9
20mucinous adenocarcinoma10.7
21cardiac tamponade10.5
22neuroendocrine carcinoma10.5
23bile duct signet ring cell carcinoma10.5
24pancreatic signet ring cell adenocarcinoma10.5
25gastric signet ring cell adenocarcinoma10.5
26bladder signet ring cell adenocarcinoma10.5
27bladder adenocarcinoma10.5
28prostate signet ring cell adenocarcinoma10.4
29ampullary signet ring cell adenocarcinoma10.4
30small cell carcinoma10.4
31duodenitis10.4
32colon signet ring adenocarcinoma10.4
33tubular adenocarcinoma10.4
34colon mucinous adenocarcinoma10.4
35colon adenocarcinoma10.4
36signet ring basal cell carcinoma10.2
37erysipelas10.2
38clear cell adenocarcinoma10.2
39gallbladder signet ring cell adenocarcinoma10.2
40breast signet ring cell adenocarcinoma10.2
41pleomorphic carcinoma10.2
42gastric lymphoma10.2
43gastric small cell carcinoma10.2
44gastric tubular adenocarcinoma10.2
45thrombotic thrombocytopenic purpura10.2
46lung lymphoma10.2
47barrett's esophagus10.2
48gastrointestinal stromal tumor10.2
49gastric squamous cell carcinoma10.2
50spindle cell carcinoma10.2

Graphical network of the top 20 diseases related to Diffuse Gastric Cancer:



Diseases related to diffuse gastric cancer

Clinical Features for Diffuse Gastric Cancer

About this section

Drugs & Therapeutics for Diffuse Gastric Cancer

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diffuse Gastric Cancer

Drug clinical trials:

Search ClinicalTrials for Diffuse Gastric Cancer

Search NIH Clinical Center for Diffuse Gastric Cancer

Search CenterWatch for Diffuse Gastric Cancer

Genetic Tests for Diffuse Gastric Cancer

About this section

Anatomical Context for Diffuse Gastric Cancer

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Diffuse Gastric Cancer:

32
Lung, Pancreas, Breast, Skin, Prostate

Animal Models for Diffuse Gastric Cancer or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Diffuse Gastric Cancer:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.8IRF1, FGFR2, IL1B
2MP:00053799.5PIK3CA, FGFR2, KRAS, ERCC2, CDH3
3MP:00053809.3FGFR2, HNRNPU, KLF6, ERBB2
4MP:00020069.2IL1B, ERBB2, KRAS, FGFR2, CDH1, PIK3CA
5MP:00053899.0PIK3CA, KRAS, IL1RN, FGFR2, CDH1, ERBB2
6MP:00107718.5GSTP1, ERCC1, KRAS, FGFR2, CDH3, PIK3CA
7MP:00053768.5FGFR2, GSTT1, PIK3CA, IRF1, MTR, MUTYH
8MP:00053858.5KRAS, IL1B, KLF6, PIK3CA, FGFR2, CDH1
9MP:00053848.0IL1RN, CDH1, KRAS, ERCC1, ERBB2, ERCC2
10MP:00053878.0CDH1, FGFR2, KRAS, IL1RN, IL1B, PIK3CA
11MP:00053787.6ERCC2, KLF6, HNRNPU, PIK3CA, CDH1, FGFR2
12MP:00107687.2HNRNPU, IL1RN, FGFR2, CDH1, MUTYH, MTR

Publications for Diffuse Gastric Cancer

About this section

Genetic Variations for Diffuse Gastric Cancer

About this section

Expression for genes affiliated with Diffuse Gastric Cancer

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diffuse Gastric Cancer

Search GEO for disease gene expression data for Diffuse Gastric Cancer.

Pathways for genes affiliated with Diffuse Gastric Cancer

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 49PharmGKB, 55SinoBiological, 59Tocris Bioscience, 12EMD Millipore, 53Reactome, 52R&D Systems
See all sources

Pathways related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0FGFR2, KRAS
210.0CASP10, CDH1, CDH3
39.9XRCC3, ERCC2
49.9ERBB2, CDH1, CASP10
59.8PIK3CA, CDH1, FGFR2
6
Hide members
9.8CASP10, PIK3CA, FGFR2
7
Immune response Bacterial infections in normal airways
Hide members
9.8IL1RN, IRF1, IL1B
89.8ERBB2, CDH1, PIK3CA
9
Immune response IFN gamma signaling pathway
Hide members
9.8IRF1, PIK3CA, IL1B
10
Hide members
9.8FGFR2, PIK3CA, KRAS
119.8KRAS, ERBB2, FGFR2
12
Hide members
9.8IL1B, PIK3CA, IL1RN
13
Hide members
9.8PIK3CA, KRAS, ERBB2
149.6GSTT1, GSTP1
15
Hide members
9.6PIK3CA, CASP10, IL1B, KRAS
16
Hide members
9.6ERBB2, KRAS, CDH1, PIK3CA
17
Hide members
9.6KRAS, ERBB2, PIK3CA, CDH1
189.6KRAS, ERBB2, PIK3CA, CASP10
19
Hide members
9.5IL1B, IL1RN, PIK3CA, KRAS
20
Hide members
9.5PIK3CA, ERBB2, KRAS, FGFR2
21
Hide members
9.5ERBB2, KRAS, FGFR2, PIK3CA
22
Hide members
9.5PIK3CA, FGFR2, KRAS, ERBB2
23
Hide members
9.4PIK3CA, IL1RN, IL1B, KRAS, IRF1
24
Development Prolactin receptor signaling
Hide members
9.3ERBB2, IL1RN, IRF1, PIK3CA, KRAS
25
Hide members
9.3ERBB2, FGFR2, CDH1, CCL8
26
Hide members
9.1CASP10, ERBB2, KRAS, IL1B, FGFR2, PIK3CA
27
Hide members
9.0CASP10, IRF1, PIK3CA, CDH1, IL1B, FGFR2
288.9ERBB2, PIK3CA, CDH1, GSTP1, KRAS, FGFR2
29
Hide members
8.9IL1B, ERBB2, FGFR2, CDH1, CASP10, CCL8
30
Hide members
8.7ERBB2, CCL8, IL1B, FGFR2, CDH3, CDH1

Compounds for genes affiliated with Diffuse Gastric Cancer

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1erlotinib44 49 1112.0ERBB2, PIK3CA, KRAS, CDH1
2chi 2449.9CDH1, IL1RN, GSTT1
3creatinine449.9GSTT1, IL1RN, CDH1
4gefitinib44 49 1111.9PIK3CA, CDH1, KRAS, ERBB2
5vitamin d449.8FGFR2, KRAS, ERBB2
6platinum compounds499.8GSTP1, ERCC2, ERCC1
7vinorelbine44 1110.7ERCC2, ERBB2, ERCC1
8o6-methylguanine449.6GSTP1, KRAS, CDH1
9p002449.6GSTT1, ERBB2, KRAS, IL1RN, CDH1
10peptidoglycan44 2810.6CCL8, PIK3CA, IL1RN, IL1B
11p003449.6GSTT1, XRCC3, IL1RN, CDH1
12adriamycin449.5GSTP1, IRF1
13tamoxifen44 49 28 1112.5IRF1, ERBB2, FGFR2, CDH1, PIK3CA
14oxygen44 2410.5KRAS, MTR, FGFR2, IRF1
15h2o2449.5FGFR2, PIK3CA, ERBB2, KRAS, MUTYH, IL1RN
16melphalan44 1110.4XRCC3, GSTP1, ERCC2, ERCC1
17phosphotyrosine449.4ERBB2, PIK3CA, FGFR2, CDH1, HNRNPU
18aspirin44 49 28 2412.4ERBB2, IL1B, IL1RN, CDH1, GSTP1
19rapamycin449.4FGFR2, ERBB2, ERCC1, KRAS, PIK3CA, CDH1
20bcnu449.4GSTP1, ERCC1, ERCC2, GSTT1
21platinum44 4910.4ERCC2, GSTP1, ERCC1, GSTT1
22agar449.4CDH1, FGFR2, GSTP1, ERBB2, PIK3CA
23carboplatin44 49 1111.3ERCC1, GSTP1, GSTT1, ERBB2
24paraffin449.3GSTP1, ERBB2, KRAS, CDH3, CDH1, FGFR2
25serine449.2CDH1, KLF6, CASP10, IRF1, PIK3CA, IL1RN
26n acetylcysteine449.2XRCC3, CDH1, FGFR2, IL1B, ERBB2, GSTP1
27nitric oxide44 11 2411.2CDH3, MTR, IL1B, IRF1, KLF6, PIK3CA
28hydrocarbons449.2GSTP1, ERCC2, GSTT1
29irinotecan44 49 1111.2KRAS, ERCC1, ERBB2, ERCC2, GSTP1, CDH1
30genistein44 28 59 2 11 2414.2GSTP1, ERBB2, IL1B, FGFR2, CDH1, PIK3CA
31adenylate449.1IL1RN, FGFR2, CDH1, PIK3CA, KLF6, GSTP1
32docetaxel44 49 59 1112.1CDH1, ERBB2, ERCC1, ERCC2, PIK3CA, GSTP1
33heparin44 28 11 2412.1CCL8, ERBB2, IL1RN, CDH1, PIK3CA, HNRNPU
34valine449.1ERBB2, MTR, KRAS, GSTP1, GSTT1
35phosphatidylinositol449.0ERBB2, KRAS, IL1RN, FGFR2, CDH1, PIK3CA
36thymidylate449.0GSTP1, ERCC2, ERBB2, ERCC1, MTR, CDH1
37progesterone44 59 28 11 2413.0CCL8, PIK3CA, FGFR2, CDH3, CDH1, IL1RN
38oxaliplatin44 49 1111.0ERBB2, KRAS, GSTP1, ERCC2, GSTT1, ERCC1
39cyclophosphamide44 49 1110.9ERCC2, ERCC1, FGFR2, GSTT1, GSTP1, ERBB2
40etoposide44 49 59 1111.9PIK3CA, CDH1, ERCC1, ERBB2, GSTT1, GSTP1
41retinoic acid44 249.9IRF1, PIK3CA, GSTP1, KRAS, IL1B, CDH1
42doxorubicin44 49 1110.8GSTT1, ERBB2, ERCC1, FGFR2, CDH1, PIK3CA
43arginine448.8GSTP1, CDH1, IRF1, PIK3CA, FGFR2, ERBB2
44paclitaxel44 49 1110.7GSTP1, KRAS, FGFR2, CDH1, PIK3CA, ERCC1
455fluorouracil448.7PIK3CA, CDH1, FGFR2, KRAS, ERCC1, ERBB2
46folate448.7GSTP1, GSTT1, XRCC3, MTR, CDH1, ERBB2
47methotrexate44 49 1110.6MTR, CDH1, IL1B, ERCC1, GSTP1, ERCC2
48vegf448.2GSTP1, IL1RN, FGFR2, PIK3CA, IL1B, KRAS
49tyrosine448.2PIK3CA, CDH3, FGFR2, IL1RN, HNRNPU, IRF1
50cisplatin44 49 59 1110.5FGFR2, KRAS, ERCC2, MTR, ERCC1, GSTT1

GO Terms for genes affiliated with Diffuse Gastric Cancer

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1UV protectionGO:00965010.0ERCC1, ERCC2
2multicellular organism growthGO:0352649.8FGFR2, ERCC1, ERCC2
3positive regulation of protein phosphorylationGO:0019349.8ERBB2, IL1B, KRAS
4regulation of ERK1 and ERK2 cascadeGO:0703729.8ERBB2, GSTP1, FGFR2
5cytokine-mediated signaling pathwayGO:0192219.8KLF6, IRF1, KRAS, IL1B
6fibroblast growth factor receptor signaling pathwayGO:0085439.8FGFR2, PIK3CA, KRAS, ERBB2
7Fc-epsilon receptor signaling pathwayGO:0380959.8PIK3CA, ERBB2, KRAS, FGFR2
8epidermal growth factor receptor signaling pathwayGO:0071739.7FGFR2, PIK3CA, ERBB2, KRAS
9embryonic organ developmentGO:0485689.6ERCC1, FGFR2
10neurotrophin TRK receptor signaling pathwayGO:0480119.5PIK3CA, KRAS, ERBB2, FGFR2
11positive regulation of transcription, DNA-dependentGO:0458939.5IRF1, ERCC2, CDH1, KLF6, IL1B
12apoptotic processGO:0069159.4CASP10, IRF1, CDH1, FGFR2, IL1B, ERCC2
13innate immune responseGO:0450879.3CASP10, PIK3CA, KRAS, ERBB2, FGFR2
14DNA repairGO:0062819.3MUTYH, ERCC1, XRCC3, ERCC2

Molecular functions related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.0IL1RN, IL1B
2protein bindingGO:0055156.8HNRNPU, CASP10, XRCC3, IRF1, PIK3CA, MUTYH

Products for genes affiliated with Diffuse Gastric Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diffuse Gastric Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet