MCID: DFF019
MIFTS: 45

Diffuse Gastric Cancer malady

Rare diseases, Gastrointestinal diseases, Cancer diseases categories

Summaries for Diffuse Gastric Cancer

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NIH Rare Diseases:41 Diffuse gastric cancer is a type of cancer found most often in the glandular cells lining the stomach, but can also develop in the bowel, breast, pancreas, bladder, prostate or lung. the term "signet ring cell" is often used because the cells look like signet rings when viewed under a microscope. the signet cells are a type of epithelial cell. epithelial tissue is skin tissue, covering and lining the body both inside and out.  last updated: 12/16/2011

MalaCards based summary: Diffuse Gastric Cancer, also known as signet ring cell gastric carcinoma, is related to gastric cancer risk after h. pylori infection and breast cancer. An important gene associated with Diffuse Gastric Cancer is CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), and among its related pathways are E-cadherin signaling in keratinocytes and Signaling by Interleukins. The compounds vinylchloride and chi 2 have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and pancreas, and related mouse phenotypes are skeleton and immune system.

Aliases & Classifications for Diffuse Gastric Cancer

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Diffuse Gastric Cancer, Aliases & Descriptions:

Name: Diffuse Gastric Cancer 41
Signet Ring Cell Gastric Carcinoma 41
Signet Ring Gastric Carcinoma 41
 
Carcinoma, Signet Ring Cell 60
Signet Cell Adenocarcinoma 41
Signet Ring Cell Carcinoma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Gastrointestinal diseases


Related Diseases for Diffuse Gastric Cancer

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Diseases related to Diffuse Gastric Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1gastric cancer risk after h. pylori infection32.1IL1RN
2breast cancer31.1CDH1, ERBB2
3tubular adenocarcinoma31.0CTNNB1, CTNNA1, CDH1, ERBB2
4gastric cancer, somatic30.8ERBB2, KRAS
5cleft lip30.6GSTM1, MTR
6pancreatitis30.2GSTP1, KRAS, IL1B
7basal cell carcinoma29.6CTNNB1, GSTM1, CDH3, ERCC1, XRCC3, GSTT1
8adenoma28.3CTNNA1, CDH1, CDH3, KRAS, ERCC1, ERCC2
9adenocarcinoma28.2CTNNA1, CTNNB1, CDH1, XRCC3, GSTM1, GSTP1
10mucinous adenocarcinoma10.7
11bile duct signet ring cell carcinoma10.6
12cardiac tamponade10.5
13pancreatic signet ring cell adenocarcinoma10.5
14intervertebral disc disease10.5IL1B
15dengue shock syndrome10.5IL1RN
16hailey-hailey disease10.5CDH3
17duodenitis10.5
18gallbladder signet ring cell adenocarcinoma10.5
19signet ring cell adenocarcinoma10.5
20prostate signet ring cell adenocarcinoma10.5
21ampullary signet ring cell adenocarcinoma10.5
22small cell carcinoma10.5
23microinvasive gastric cancer10.4CDH1, CTNNA1
24cinca syndrome10.4IL1RN, IL1B
25exanthem10.4KRAS, IL1RN
26inflammatory breast carcinoma10.4CDH1, ERBB2
27chorioamnionitis10.4IL1B, IL1RN
28bronchiolo-alveolar adenocarcinoma10.4CDH1, KRAS
29breast ductal carcinoma10.4ERBB2, CDH1, CDH3
30periodontitis10.3IL1B
31salivary gland adenoid cystic carcinoma10.3CDH1, CTNNA1, ERBB2
32goblet cell carcinoid10.3CTNNB1, CDH1
33papillary carcinoma10.3CDH1, ERBB2, CDH3
34stomach cancer10.3CDH1, ERBB2
35trichothiodystrophy10.3ERCC1, ERCC2
36colitis10.3CDH3, IL1B, IL1RN
37ductal carcinoma in situ10.3ERBB2, CDH1
38gastrointestinal stromal tumor10.3
39burkitt lymphoma10.3
40hemolytic anemia10.3
41neuroendocrine carcinoma10.3
42thrombotic thrombocytopenic purpura10.3
43choledochal cyst10.3
44large cell carcinoma10.3
45erysipelas10.3
46breast signet ring cell adenocarcinoma10.3
47pleomorphic carcinoma10.3
48dermatomyositis10.3
49elephantiasis10.3
50lung squamous cell carcinoma10.3

Graphical network of the top 20 diseases related to Diffuse Gastric Cancer:



Diseases related to diffuse gastric cancer

Symptoms for Diffuse Gastric Cancer

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Drugs & Therapeutics for Diffuse Gastric Cancer

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Drug clinical trials:

Search ClinicalTrials for Diffuse Gastric Cancer

Search NIH Clinical Center for Diffuse Gastric Cancer

Genetic Tests for Diffuse Gastric Cancer

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Anatomical Context for Diffuse Gastric Cancer

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MalaCards organs/tissues related to Diffuse Gastric Cancer:

31
Breast, Lung, Pancreas, Skin, Prostate, Testes

Animal Models for Diffuse Gastric Cancer or affiliated genes

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Publications for Diffuse Gastric Cancer

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Articles related to Diffuse Gastric Cancer:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Prospective cohort study assessing outcomes of patients from families fulfilling criteria for hereditary diffuse gastric cancer undergoing endoscopic surveillance. (24472763)
2014
2
Hereditary diffuse gastric cancer associated with E-cadherin germline mutation: a case report. (25089230)
2014
3
Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. (25315765)
2014
4
Genetic screening analysis of patients with hereditary diffuse gastric cancer from northern and northeastern Brazil. (25180051)
2014
5
An I+-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. (23208944)
2013
6
Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients. (23264079)
2013
7
Laparoscopic prophylactic total gastrectomy with linear stapler side-to-side esophagojejunal anastomosis for hereditary diffuse gastric cancer syndrome in 2 siblings. (23752020)
2013
8
A systematic review of the indications for genetic testing and prophylactic gastrectomy among patients with hereditary diffuse gastric cancer. (22160243)
2012
9
Hereditary diffuse gastric cancer: the always-forgotten Meckel's diverticulum. (22240148)
2012
10
Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations after topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies. (23073328)
2012
11
De novo CDH1 mutation in a family presenting with early-onset diffuse gastric cancer. (21696387)
2012
12
Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report. (21992816)
2012
13
Diffuse gastric cancer with peritoneal carcinomatosis can mimic Crohn's disease. (23185152)
2012
14
CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. (22020549)
2012
15
Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer. (21276134)
2011
16
Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer. (21271559)
2011
17
Preventive and therapeutic implications of positive CDH1 testing in diffuse gastric cancer. (21761101)
2011
18
The identification and management of hereditary diffuse gastric cancer in a large Jordanian family. (21681551)
2011
19
Prophylactic laparoscopic gastrectomy for hereditary diffuse gastric cancer: a case series in a single family. (21333186)
2010
20
A novel truncating mutation in the E-cadherin gene in the first Iranian family with hereditary diffuse gastric cancer. (20471195)
2010
21
Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation. (20624523)
2010
22
Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. (19965908)
2010
23
Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. (19408054)
2009
24
Hereditary diffuse gastric cancer: a manifestation of lost cell polarity. (19432899)
2009
25
CDH1 testing: can it predict the prophylactic or therapeutic nature of total gastrectomy in hereditary diffuse gastric cancer? (19636637)
2009
26
Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer. (19247957)
2009
27
Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. (19269290)
2009
28
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population. (18482459)
2008
29
Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. (17513507)
2008
30
Hereditary diffuse gastric cancer and lost cell polarity: a short path to cancer. (18407736)
2008
31
Hereditary diffuse gastric cancer: surgery, surveillance and unanswered questions. (18684065)
2008
32
Endogastric capsule for E-cadherin gene (CDH1) promoter hypermethylation assessment in DNA from gastric juice of diffuse gastric cancer patients. (17986624)
2008
33
Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. (17363565)
2007
34
E-cadherin and hereditary diffuse gastric cancer. (17981184)
2007
35
CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. (17522512)
2007
36
E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. (16600987)
2006
37
Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer. (15831593)
2006
38
A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. (16870389)
2006
39
Diffuse gastric cancer. (16770139)
2006
40
Genetic aetiology of diffuse gastric cancer: so near, yet so far. (15235018)
2004
41
Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. (15102685)
2004
42
Germline mutational analysis of CDH1 and pathologic features in familial cancer syndrome with diffuse gastric cancer/breast cancer proband in a Chinese family. (15135482)
2004
43
The unsolved enigma of CDH1 down-regulation in hereditary diffuse gastric cancer. (15313375)
2004
44
Screening E-cadherin germline mutations in Italian patients with familial diffuse gastric cancer: an analysis in the District of Urbino, Region Marche, Central Italy. (12908778)
2003
45
Genetic screening for hereditary diffuse gastric cancer. (12647996)
2003
46
E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. (12216071)
2002
47
Hereditary diffuse gastric cancer: more answers or more questions? (11875020)
2002
48
Novel germline CDH1 mutations in hereditary diffuse gastric cancer families. (11968084)
2002
49
Hereditary diffuse gastric cancer. (11665720)
2001
50
Hereditary Diffuse Gastric Cancer (20301318)
1993

Variations for Diffuse Gastric Cancer

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Expression for genes affiliated with Diffuse Gastric Cancer

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Search GEO for disease gene expression data for Diffuse Gastric Cancer.

Pathways for genes affiliated with Diffuse Gastric Cancer

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Pathways related to Diffuse Gastric Cancer according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CDH1, CTNNA1
2
Show member pathways
9.7KRAS, IL1B, IL1RN
3
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.7ERBB2, KRAS, IL1RN
4
Show member pathways
9.5GSTP1, ERCC1
59.4GSTP1, GSTT1
69.2CDH1, CDH3, CTNNB1
79.2CTNNB1, CTNNA1, CDH1
89.2CTNNB1, CDH1, CTNNA1
99.2CDH1, CTNNB1, CTNNA1
109.2CTNNA1, CTNNB1, CDH1
119.2CTNNA1, CDH1, CTNNB1
129.2CTNNA1, CDH1, CTNNB1
139.2CDH1, CTNNB1, CTNNA1
14
Show member pathways
RAC1 signaling pathway36
9.2CTNNA1, CTNNB1, CDH1
159.2CTNNA1, CTNNB1, CDH1
169.2KRAS, CTNNB1, CDH1
179.2CTNNB1, KRAS, CTNNA1
18
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.2CTNNB1, CDH1, ERBB2
199.2CDH1, CTNNB1, ERBB2
209.1IL1B, IL1RN, CTNNB1
219.0CTNNB1, CTNNA1, CDH1, CDH3
229.0CTNNB1, CDH3, CTNNA1, CDH1
239.0CDH1, CTNNB1, CTNNA1, CDH3
249.0CDH1, CDH3, CTNNA1, CTNNB1
25
Show member pathways
9.0CDH1, CTNNB1, CTNNA1, CDH3
26
Show member pathways
8.9CTNNB1, CDH1, CDH3, ERBB2
278.9ERBB2, CDH1, CTNNB1, CTNNA1
28
Show member pathways
8.9GSTT1, GSTP1, GSTM1
29
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
8.9GSTT1, GSTP1, GSTM1
308.9GSTM1, GSTP1, GSTT1
318.9GSTP1, GSTM1, GSTT1
328.9CTNNB1, CDH1, KRAS, XRCC3
33
Show member pathways
8.9ERBB2, CTNNB1, CTNNA1, KRAS
34
Show member pathways
8.8KRAS, CTNNB1, IL1B, ERBB2
35
Show member pathways
Signal transduction PTEN pathway58
8.7KRAS, CTNNB1, ERBB2, CDH1, CTNNA1
36
Show member pathways
8.5MTR, GSTT1, GSTM1, GSTP1
37
Show member pathways
Signaling Pathways in Glioblastoma36
8.3ERBB2, GSTP1, KRAS, CTNNB1, CDH1
38
Show member pathways
8.1CTNNA1, CTNNB1, CDH1, ERBB2, CCL8, IL1B
398.1KRAS, ERBB2, GSTP1, CDH1, CTNNB1, CTNNA1
40
Show member pathways
7.9CTNNA1, CCL8, IL1B, ERBB2, CDH3, CTNNB1

Compounds for genes affiliated with Diffuse Gastric Cancer

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Compounds related to Diffuse Gastric Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1vinylchloride439.6GSTM1, GSTT1, KRAS
2chi 2439.5GSTM1, GSTT1, CDH1, IL1RN
3platinum compounds499.4ERCC1, ERCC2, GSTP1
4leucovorin43 49 1211.4XRCC3, ERBB2, KRAS, ERCC1, ERCC2
5methylchloride439.3GSTM1, GSTT1, GSTP1
6s-phenylmercapturic acid439.3GSTM1, GSTT1, GSTP1
7cumene hydroperoxide439.2GSTT1, GSTM1, GSTP1
81,3-butadiene439.2GSTT1, GSTP1, GSTM1
9fluorouracil49 1210.2ERCC1, GSTP1, XRCC3, ERCC2
10p003439.2XRCC3, GSTM1, IL1RN, GSTT1, CDH1
11bcnu439.2ERCC1, GSTT1, ERCC2, GSTP1
12cetuximab43 49 1211.1CTNNB1, KRAS, ERBB2, ERCC1
13melphalan43 49 1211.1GSTP1, ERCC2, XRCC3, ERCC1
14platinum43 4910.1GSTP1, GSTT1, ERCC2, ERCC1
151-hydroxypyrene439.1GSTM1, GSTT1, GSTP1
16styrene439.1GSTP1, GSTT1, GSTM1
17celecoxib43 59 28 49 24 1214.0ERBB2, CDH1, IL1B, CTNNB1
18trichloroethylene439.0GSTT1, GSTP1, GSTM1
19hydrocarbons438.9GSTM1, ERCC2, GSTT1, GSTP1
201-chloro-24-dinitrobenzene438.9GSTM1, GSTT1, GSTP1
21ifosfamide43 129.9GSTT1, GSTP1, ERCC1, GSTM1
22gefitinib43 49 1210.9CTNNB1, CDH1, KRAS, ERBB2
23manganese superoxide438.9GSTM1, IL1RN, GSTP1, GSTT1
24benzo(a)pyrene438.9GSTM1, ERCC1, GSTP1, GSTT1
25docetaxel43 49 59 1211.8XRCC3, ERCC2, ERCC1, CDH1, ERBB2, GSTP1
26carboplatin43 49 1210.7GSTM1, GSTT1, ERBB2, ERCC1, GSTP1
27irinotecan43 49 1210.6ERCC1, XRCC3, KRAS, CDH1, ERBB2, GSTP1
28vincristine43 49 1210.6ERCC2, GSTM1, GSTP1, ERCC1, MTR
29curcumin438.6ERBB2, CTNNB1, CDH1, GSTP1, IL1B
30etoposide43 49 59 1211.5ERCC1, CDH1, ERBB2, GSTT1, GSTP1
31vitamin d438.5KRAS, ERBB2, CDH1, CTNNB1, GSTM1, IL1RN
32paraffin438.5KRAS, GSTP1, ERBB2, CDH3, CTNNB1, CTNNA1
33aspirin43 49 28 2411.4CDH1, ERBB2, CTNNB1, IL1B, IL1RN, GSTP1
34n acetylcysteine438.3XRCC3, CTNNB1, CDH1, IL1B, GSTP1, ERBB2
35valine438.3GSTT1, GSTP1, GSTM1, ERBB2, MTR, KRAS
36phosphotyrosine438.3CTNNA1, CDH1, HNRNPU, ERBB2, CTNNB1
37oxaliplatin43 49 1210.2GSTT1, GSTP1, GSTM1, KRAS, ERCC1, ERCC2
38p002438.2KRAS, ERBB2, CTNNB1, IL1RN, GSTM1, GSTT1
39thymidylate438.2ERBB2, GSTP1, GSTM1, MTR, CDH1, ERCC1
40creatinine438.1GSTT1, GSTP1, GSTM1, MTR, IL1RN, ERCC1
41cyclophosphamide43 49 129.9GSTM1, GSTP1, ERBB2, ERCC2, ERCC1, MTR
42paclitaxel43 49 129.8GSTP1, ERBB2, ERCC1, KRAS, CDH1, CTNNA1
43folate437.8CDH1, GSTT1, MTR, ERBB2, ERCC2, GSTP1
44methotrexate49 43 129.7GSTP1, ERBB2, MTR, IL1RN, CDH1, ERCC1
455fluorouracil437.5ERBB2, GSTP1, ERCC2, ERCC1, KRAS, CDH1
46tyrosine437.4CTNNA1, HNRNPU, CCL8, IL1RN, ERBB2, ERCC1
47vegf437.3CTNNA1, GSTP1, CTNNB1, IL1RN, IL1B, ERBB2
48doxorubicin43 49 129.2ERCC1, GSTT1, GSTP1, CTNNB1, CDH1, ERBB2
49estrogen436.6IL1RN, GSTT1, KRAS, CDH1, CTNNB1, CDH3
50cisplatin43 49 59 129.4ERCC1, ERCC2, ERBB2, XRCC3, GSTM1, MTR

GO Terms for genes affiliated with Diffuse Gastric Cancer

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Cellular components related to Diffuse Gastric Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1zonula adherensGO:00059159.5CTNNB1, CTNNA1
2catenin complexGO:00163429.4CDH1, CTNNA1, CTNNB1
3cell-cell adherens junctionGO:00059139.4CTNNB1, CDH1, CDH3
4basolateral plasma membraneGO:00163239.1ERBB2, CDH1, CTNNB1
5perinuclear region of cytoplasmGO:00484718.9CTNNB1, CDH1, ERBB2, XRCC3
6plasma membraneGO:00058867.6IL1RN, GSTP1, ERBB2, KRAS, CDH3, CDH1
7cytosolGO:00058296.8GSTP1, CTNNA1, CTNNB1, GSTT1, MTR, IL1B
8cytoplasmGO:00057376.7CTNNB1, XRCC3, IL1RN, GSTM1, CDH1, CDH3

Biological processes related to Diffuse Gastric Cancer according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:000166010.2IL1B, IL1RN
2adherens junction organizationGO:003433210.1CTNNA1, CDH1, CDH3
3cell-cell junction organizationGO:004521610.0CDH3, CDH1, CTNNA1
4cell junction assemblyGO:003432910.0CTNNA1, CDH1, CDH3
5UV protectionGO:00096509.9ERCC1, ERCC2
6positive regulation of protein phosphorylationGO:00019349.8IL1B, ERBB2, KRAS
7nucleotide-excision repair, DNA damage removalGO:00007189.8ERCC1, ERCC2
8regulation of protein localization to cell surfaceGO:020000089.7CTNNB1, CDH1
9regulation of ERK1 and ERK2 cascadeGO:00703729.6GSTP1, ERBB2
10cellular response to indole-3-methanolGO:00716819.5CTNNA1, CTNNB1, CDH1
11hair cell differentiationGO:00353159.5CTNNB1, ERCC2
12positive regulation of muscle cell differentiationGO:00511499.4CTNNA1, CTNNB1
13glutathione derivative biosynthetic processGO:019016879.2GSTT1, GSTP1, GSTM1
14glutathione metabolic processGO:00067499.2GSTM1, GSTP1, GSTT1
15regulation of angiogenesisGO:00457659.1CTNNB1, ERBB2
16response to drugGO:00424938.9IL1RN, GSTT1, CDH3, CDH1, CTNNB1
17xenobiotic metabolic processGO:00068058.8MTR, GSTM1, GSTP1, GSTT1
18positive regulation of transcription, DNA-templatedGO:00458938.7IL1B, ERCC2, CDH1, CTNNB1

Molecular functions related to Diffuse Gastric Cancer according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:004529510.1CTNNA1, CDH1
2interleukin-1 receptor bindingGO:000514910.0IL1B, IL1RN
3cadherin bindingGO:00452969.4CTNNA1, CTNNB1
4protein domain specific bindingGO:00199049.4IL1B, ERCC1, CDH1
5protein phosphatase bindingGO:00199039.3ERBB2, CDH1, CTNNB1
6glutathione transferase activityGO:00043649.1GSTT1, GSTP1, GSTM1
7protein C-terminus bindingGO:00080228.9CTNNB1, ERCC1, ERCC2, ERBB2
8protein bindingGO:00055156.6ERBB2, GSTP1, HNRNPU, XRCC3, ERCC2, ERCC1

Products for genes affiliated with Diffuse Gastric Cancer

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Sources for Diffuse Gastric Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet