MCID: DFF019
MIFTS: 54

Diffuse Gastric Cancer malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases categories
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Summaries for Diffuse Gastric Cancer

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NIH Rare Diseases:42 Diffuse gastric cancer is a type of cancer found most often in the glandular cells lining the stomach, but can also develop in the bowel, breast, pancreas, bladder, prostate or lung. the term "signet ring cell" is often used because the cells look like signet rings when viewed under a microscope. the signet cells are a type of epithelial cell. epithelial tissue is skin tissue, covering and lining the body both inside and out.  last updated: 12/16/2011

MalaCards based summary: Diffuse Gastric Cancer, also known as signet ring cell gastric carcinoma, is related to hereditary diffuse gastric cancer and gastric cancer risk after h. pylori infection. An important gene associated with Diffuse Gastric Cancer is CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), and among its related pathways are E-cadherin signaling in keratinocytes and Signaling by Interleukins. The compounds vinylchloride and chi 2 have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and pancreas, and related mouse phenotypes are skeleton and immune system.

Aliases & Classifications for Diffuse Gastric Cancer

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Diffuse Gastric Cancer, Aliases & Descriptions:

Name: Diffuse Gastric Cancer 42
Signet Ring Cell Gastric Carcinoma 42
Signet Ring Gastric Carcinoma 42
 
Carcinoma, Signet Ring Cell 62
Signet Cell Adenocarcinoma 42
Signet Ring Cell Carcinoma 42


Classifications:



Related Diseases for Diffuse Gastric Cancer

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Diseases in the Hereditary Diffuse Gastric Cancer family:

diffuse gastric cancer

Diseases related to Diffuse Gastric Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary diffuse gastric cancer32.6CDH1
2gastric cancer risk after h. pylori infection31.2IL1RN
3tubular adenocarcinoma30.9ERBB2, CDH1, CTNNB1, CTNNA1
4gastric cancer, somatic30.8KRAS, ERBB2
5breast cancer30.7ERBB2, KRAS, CDH1, CTNNB1
6cleft lip30.6GSTM1, MTR
7bladder carcinoma30.3GSTP1, ERBB2, CDH3, CDH1, CTNNA1
8pancreatitis30.2IL1B, GSTP1, KRAS
9basal cell carcinoma29.6XRCC3, GSTM1, GSTT1, ERCC2, ERCC1, CDH3
10adenoma28.3CTNNA1, CTNNB1, CDH1, CDH3, KRAS, ERCC1
11adenocarcinoma28.1CTNNA1, CTNNB1, CDH1, CDH3, KRAS, ERCC1
12gastric cancer11.1
13mucinous adenocarcinoma10.7
14pancreatic signet ring cell adenocarcinoma10.6
15cardiac tamponade10.5
16bile duct signet ring cell carcinoma10.5
17signet ring cell adenocarcinoma10.5
18prostate signet ring cell adenocarcinoma10.5
19degenerative disc disease10.5IL1B
20dengue shock syndrome10.5IL1RN
21hailey-hailey disease10.5CDH3
22small cell carcinoma10.5
23duodenitis10.5
24gallbladder signet ring cell adenocarcinoma10.5
25breast signet ring cell adenocarcinoma10.5
26ampullary signet ring cell adenocarcinoma10.5
27microinvasive gastric cancer10.4CTNNA1, CDH1
28chronic infantile neurological cutaneous articular syndrome10.4IL1B, IL1RN
29exanthem10.4IL1RN, KRAS
30inflammatory breast carcinoma10.4CDH1, ERBB2
31chorioamnionitis10.4IL1RN, IL1B
32bronchiolo-alveolar adenocarcinoma10.4KRAS, CDH1
33breast ductal carcinoma10.4CDH1, CDH3, ERBB2
34periodontitis10.3IL1B
35breast cancer, invasive ductal10.3ERBB2, CDH1
36salivary gland adenoid cystic carcinoma10.3CTNNA1, CDH1, ERBB2
37goblet cell carcinoid10.3CDH1, CTNNB1
38papillary carcinoma10.3CDH1, CDH3, ERBB2
39stomach cancer10.3ERBB2, CDH1
40photosensitive trichothiodystrophy10.3ERCC1, ERCC2
41colitis10.3IL1RN, IL1B, CDH3
42ductal carcinoma in situ10.3CDH1, ERBB2
43hemolytic anemia10.3
44neuroendocrine carcinoma10.3
45choledochal cyst10.3
46pleomorphic carcinoma10.3
47gastrointestinal stromal tumor10.3
48large cell carcinoma10.3
49thrombotic thrombocytopenic purpura10.3
50dermatomyositis10.3

Graphical network of the top 20 diseases related to Diffuse Gastric Cancer:



Diseases related to diffuse gastric cancer

Symptoms for Diffuse Gastric Cancer

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Drugs & Therapeutics for Diffuse Gastric Cancer

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Drug clinical trials:

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Genetic Tests for Diffuse Gastric Cancer

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Anatomical Context for Diffuse Gastric Cancer

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MalaCards organs/tissues related to Diffuse Gastric Cancer:

32
Breast, Lung, Pancreas, Skin, Prostate, Testes

Animal Models for Diffuse Gastric Cancer or affiliated genes

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Publications for Diffuse Gastric Cancer

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Articles related to Diffuse Gastric Cancer:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Prospective cohort study assessing outcomes of patients from families fulfilling criteria for hereditary diffuse gastric cancer undergoing endoscopic surveillance. (24472763)
2014
2
Hereditary diffuse gastric cancer associated with E-cadherin germline mutation: a case report. (25089230)
2014
3
Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. (25315765)
2014
4
Genetic screening analysis of patients with hereditary diffuse gastric cancer from northern and northeastern Brazil. (25180051)
2014
5
An I+-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. (23208944)
2013
6
Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients. (23264079)
2013
7
Laparoscopic prophylactic total gastrectomy with linear stapler side-to-side esophagojejunal anastomosis for hereditary diffuse gastric cancer syndrome in 2 siblings. (23752020)
2013
8
A systematic review of the indications for genetic testing and prophylactic gastrectomy among patients with hereditary diffuse gastric cancer. (22160243)
2012
9
Hereditary diffuse gastric cancer: the always-forgotten Meckel's diverticulum. (22240148)
2012
10
Endoscopic surveillance of patients with hereditary diffuse gastric cancer: biopsy recommendations after topographic distribution of cancer foci in a series of 10 CDH1-mutated gastrectomies. (23073328)
2012
11
De novo CDH1 mutation in a family presenting with early-onset diffuse gastric cancer. (21696387)
2012
12
Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report. (21992816)
2012
13
Diffuse gastric cancer with peritoneal carcinomatosis can mimic Crohn's disease. (23185152)
2012
14
CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. (22020549)
2012
15
Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer. (21276134)
2011
16
Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer. (21271559)
2011
17
Preventive and therapeutic implications of positive CDH1 testing in diffuse gastric cancer. (21761101)
2011
18
The identification and management of hereditary diffuse gastric cancer in a large Jordanian family. (21681551)
2011
19
CDH1 gene mutations do not contribute in hereditary diffuse gastric cancer in Poland. (20842455)
2010
20
Prophylactic laparoscopic gastrectomy for hereditary diffuse gastric cancer: a case series in a single family. (21333186)
2010
21
A novel truncating mutation in the E-cadherin gene in the first Iranian family with hereditary diffuse gastric cancer. (20471195)
2010
22
Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation. (20624523)
2010
23
Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. (19965908)
2010
24
Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. (19408054)
2009
25
Hereditary diffuse gastric cancer: a manifestation of lost cell polarity. (19432899)
2009
26
CDH1 testing: can it predict the prophylactic or therapeutic nature of total gastrectomy in hereditary diffuse gastric cancer? (19636637)
2009
27
Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer. (19247957)
2009
28
A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: a case control study in an Italian population. (18482459)
2008
29
Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. (17513507)
2008
30
Hereditary diffuse gastric cancer and lost cell polarity: a short path to cancer. (18407736)
2008
31
Hereditary diffuse gastric cancer: surgery, surveillance and unanswered questions. (18684065)
2008
32
Endogastric capsule for E-cadherin gene (CDH1) promoter hypermethylation assessment in DNA from gastric juice of diffuse gastric cancer patients. (17986624)
2008
33
Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. (17363565)
2007
34
E-cadherin and hereditary diffuse gastric cancer. (17981184)
2007
35
CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. (17522512)
2007
36
E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. (16600987)
2006
37
Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer. (15831593)
2006
38
A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. (16870389)
2006
39
Diffuse gastric cancer. (16770139)
2006
40
Genetic aetiology of diffuse gastric cancer: so near, yet so far. (15235018)
2004
41
Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. (15102685)
2004
42
Germline mutational analysis of CDH1 and pathologic features in familial cancer syndrome with diffuse gastric cancer/breast cancer proband in a Chinese family. (15135482)
2004
43
The unsolved enigma of CDH1 down-regulation in hereditary diffuse gastric cancer. (15313375)
2004
44
Screening E-cadherin germline mutations in Italian patients with familial diffuse gastric cancer: an analysis in the District of Urbino, Region Marche, Central Italy. (12908778)
2003
45
Genetic screening for hereditary diffuse gastric cancer. (12647996)
2003
46
E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. (12216071)
2002
47
Hereditary diffuse gastric cancer: more answers or more questions? (11875020)
2002
48
Novel germline CDH1 mutations in hereditary diffuse gastric cancer families. (11968084)
2002
49
Hereditary diffuse gastric cancer. (11665720)
2001
50
Hereditary Diffuse Gastric Cancer (20301318)
1993

Variations for Diffuse Gastric Cancer

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Expression for genes affiliated with Diffuse Gastric Cancer

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Expression patterns in normal tissues for genes affiliated with Diffuse Gastric Cancer

Search GEO for disease gene expression data for Diffuse Gastric Cancer.

Pathways for genes affiliated with Diffuse Gastric Cancer

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Pathways related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show all 40)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CTNNA1, CDH1
2
Show member pathways
9.7IL1RN, IL1B, KRAS
3
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.7IL1RN, ERBB2, KRAS
4
Show member pathways
9.5ERCC1, GSTP1
59.4GSTT1, GSTP1
69.2CDH3, CDH1, CTNNB1
79.2CTNNA1, CTNNB1, CDH1
89.2CTNNA1, CTNNB1, CDH1
99.2CDH1, CTNNB1, CTNNA1
109.2CDH1, CTNNB1, CTNNA1
11
Show member pathways
RAC1 signaling pathway37
9.2CTNNA1, CTNNB1, CDH1
129.2CTNNA1, CTNNB1, CDH1
139.2CDH1, CTNNB1, CTNNA1
149.2CDH1, CTNNB1, CTNNA1
159.2CTNNA1, CTNNB1, CDH1
169.2CTNNB1, CDH1, KRAS
179.2CTNNA1, CTNNB1, KRAS
189.2CTNNB1, CDH1, ERBB2
19
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.2CTNNB1, CDH1, ERBB2
209.1CTNNB1, IL1B, IL1RN
21
Show member pathways
9.0CDH3, CDH1, CTNNB1, CTNNA1
229.0CDH3, CDH1, CTNNB1, CTNNA1
239.0CDH3, CDH1, CTNNB1, CTNNA1
249.0CTNNA1, CTNNB1, CDH1, CDH3
259.0CTNNA1, CTNNB1, CDH1, CDH3
26
Show member pathways
8.9CTNNB1, CDH1, CDH3, ERBB2
278.9ERBB2, CDH1, CTNNB1, CTNNA1
288.9GSTT1, GSTP1, GSTM1
29
Show member pathways
8.9GSTM1, GSTP1, GSTT1
30
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
8.9GSTM1, GSTP1, GSTT1
318.9GSTM1, GSTP1, GSTT1
328.9XRCC3, KRAS, CDH1, CTNNB1
33
Show member pathways
8.9ERBB2, KRAS, CTNNB1, CTNNA1
34
Show member pathways
8.8CTNNB1, KRAS, ERBB2, IL1B
35
Show member pathways
Signal transduction PTEN pathway60
8.7CTNNA1, CTNNB1, CDH1, KRAS, ERBB2
36
Show member pathways
8.5MTR, GSTM1, GSTP1, GSTT1
37
Show member pathways
Signaling Pathways in Glioblastoma37
8.3GSTP1, ERBB2, KRAS, CDH1, CTNNB1
38
Show member pathways
8.1CCL8, IL1B, ERBB2, CDH1, CTNNB1, CTNNA1
398.1GSTP1, ERBB2, KRAS, CDH1, CTNNB1, CTNNA1
40
Show member pathways
7.9CCL8, IL1B, ERBB2, CDH3, CDH1, CTNNB1

Compounds for genes affiliated with Diffuse Gastric Cancer

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Compounds related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 169)
idCompoundScoreTop Affiliating Genes
1vinylchloride449.6GSTM1, GSTT1, KRAS
2chi 2449.5GSTM1, GSTT1, CDH1, IL1RN
3platinum compounds509.4ERCC1, ERCC2, GSTP1
4leucovorin44 50 1111.4XRCC3, ERBB2, KRAS, ERCC1, ERCC2
5methylchloride449.3GSTM1, GSTT1, GSTP1
6s-phenylmercapturic acid449.3GSTM1, GSTT1, GSTP1
7cumene hydroperoxide449.2GSTT1, GSTM1, GSTP1
81,3-butadiene449.2GSTT1, GSTP1, GSTM1
9fluorouracil50 1110.2ERCC1, GSTP1, XRCC3, ERCC2
10p003449.2XRCC3, GSTM1, IL1RN, GSTT1, CDH1
11bcnu449.2ERCC1, GSTT1, ERCC2, GSTP1
12cetuximab44 50 1111.1CTNNB1, KRAS, ERBB2, ERCC1
13melphalan44 50 1111.1GSTP1, ERCC2, XRCC3, ERCC1
14platinum44 5010.1GSTP1, GSTT1, ERCC2, ERCC1
151-hydroxypyrene449.1GSTM1, GSTT1, GSTP1
16styrene449.1GSTP1, GSTT1, GSTM1
17celecoxib44 61 28 50 24 1114.0ERBB2, CDH1, IL1B, CTNNB1
18trichloroethylene449.0GSTT1, GSTP1, GSTM1
19hydrocarbons448.9GSTM1, ERCC2, GSTT1, GSTP1
201-chloro-24-dinitrobenzene448.9GSTM1, GSTT1, GSTP1
21ifosfamide44 119.9GSTT1, GSTP1, ERCC1, GSTM1
22gefitinib44 50 1110.9CTNNB1, CDH1, KRAS, ERBB2
23manganese superoxide448.9GSTM1, IL1RN, GSTP1, GSTT1
24benzo(a)pyrene448.9GSTM1, ERCC1, GSTP1, GSTT1
25docetaxel44 50 61 1111.8XRCC3, ERCC2, ERCC1, CDH1, ERBB2, GSTP1
26carboplatin44 50 1110.7GSTM1, GSTT1, ERBB2, ERCC1, GSTP1
27irinotecan44 50 1110.6ERCC1, XRCC3, KRAS, CDH1, ERBB2, GSTP1
28vincristine44 50 1110.6ERCC2, GSTM1, GSTP1, ERCC1, MTR
29curcumin448.6ERBB2, CTNNB1, CDH1, GSTP1, IL1B
30etoposide44 50 61 1111.5ERCC1, CDH1, ERBB2, GSTT1, GSTP1
31vitamin d448.5KRAS, ERBB2, CDH1, CTNNB1, GSTM1, IL1RN
32paraffin448.5KRAS, GSTP1, ERBB2, CDH3, CTNNB1, CTNNA1
33aspirin44 50 28 2411.4CDH1, ERBB2, CTNNB1, IL1B, IL1RN, GSTP1
34n acetylcysteine448.3XRCC3, CTNNB1, CDH1, IL1B, GSTP1, ERBB2
35valine448.3GSTT1, GSTP1, GSTM1, ERBB2, MTR, KRAS
36phosphotyrosine448.3CTNNA1, CDH1, HNRNPU, ERBB2, CTNNB1
37oxaliplatin44 50 1110.2GSTT1, GSTP1, GSTM1, KRAS, ERCC1, ERCC2
38p002448.2KRAS, ERBB2, CTNNB1, IL1RN, GSTM1, GSTT1
39thymidylate448.2ERBB2, GSTP1, GSTM1, MTR, CDH1, ERCC1
40creatinine448.1GSTT1, GSTP1, GSTM1, MTR, IL1RN, ERCC1
41cyclophosphamide44 50 119.9GSTM1, GSTP1, ERBB2, ERCC2, ERCC1, MTR
42paclitaxel44 50 119.8GSTP1, ERBB2, ERCC1, KRAS, CDH1, CTNNA1
43folate447.8CDH1, GSTT1, MTR, ERBB2, ERCC2, GSTP1
44methotrexate50 44 119.7GSTP1, ERBB2, MTR, IL1RN, CDH1, ERCC1
455fluorouracil447.5ERBB2, GSTP1, ERCC2, ERCC1, KRAS, CDH1
46tyrosine447.4CTNNA1, HNRNPU, CCL8, IL1RN, ERBB2, ERCC1
47vegf447.3CTNNA1, GSTP1, CTNNB1, IL1RN, IL1B, ERBB2
48doxorubicin44 50 119.2ERCC1, GSTT1, GSTP1, CTNNB1, CDH1, ERBB2
49estrogen446.6IL1RN, GSTT1, KRAS, CDH1, CTNNB1, CDH3
50cisplatin44 50 61 119.4ERCC1, ERCC2, ERBB2, XRCC3, GSTM1, MTR

GO Terms for genes affiliated with Diffuse Gastric Cancer

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Cellular components related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1zonula adherensGO:0059159.5CTNNB1, CTNNA1
2catenin complexGO:0163429.4CTNNA1, CTNNB1, CDH1
3cell-cell adherens junctionGO:0059139.4CDH3, CDH1, CTNNB1
4basolateral plasma membraneGO:0163239.1ERBB2, CDH1, CTNNB1
5perinuclear region of cytoplasmGO:0484718.9CTNNB1, CDH1, ERBB2, XRCC3
6plasma membraneGO:0058867.6IL1RN, GSTP1, ERBB2, KRAS, CDH3, CDH1
7cytosolGO:0058296.8MTR, IL1B, GSTM1, GSTP1, GSTT1, CTNNB1
8cytoplasmGO:0057376.7XRCC3, IL1RN, GSTM1, GSTP1, ERBB2, ERCC2

Biological processes related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.2IL1B, IL1RN
2adherens junction organizationGO:03433210.1CTNNA1, CDH1, CDH3
3cell-cell junction organizationGO:04521610.0CDH3, CDH1, CTNNA1
4cell junction assemblyGO:03432910.0CTNNA1, CDH1, CDH3
5UV protectionGO:0096509.9ERCC1, ERCC2
6positive regulation of protein phosphorylationGO:0019349.8IL1B, ERBB2, KRAS
7nucleotide-excision repair, DNA damage removalGO:0007189.8ERCC1, ERCC2
8regulation of protein localization to cell surfaceGO:20000089.7CTNNB1, CDH1
9regulation of ERK1 and ERK2 cascadeGO:0703729.6GSTP1, ERBB2
10cellular response to indole-3-methanolGO:0716819.5CTNNA1, CTNNB1, CDH1
11hair cell differentiationGO:0353159.5CTNNB1, ERCC2
12positive regulation of muscle cell differentiationGO:0511499.4CTNNA1, CTNNB1
13glutathione derivative biosynthetic processGO:19016879.2GSTT1, GSTP1, GSTM1
14glutathione metabolic processGO:0067499.2GSTM1, GSTP1, GSTT1
15regulation of angiogenesisGO:0457659.1CTNNB1, ERBB2
16response to drugGO:0424938.9IL1RN, GSTT1, CDH3, CDH1, CTNNB1
17xenobiotic metabolic processGO:0068058.8MTR, GSTM1, GSTP1, GSTT1
18positive regulation of transcription, DNA-templatedGO:0458938.7IL1B, ERCC2, CDH1, CTNNB1

Molecular functions related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:04529510.1CTNNA1, CDH1
2interleukin-1 receptor bindingGO:00514910.0IL1B, IL1RN
3cadherin bindingGO:0452969.4CTNNA1, CTNNB1
4protein domain specific bindingGO:0199049.4IL1B, ERCC1, CDH1
5protein phosphatase bindingGO:0199039.3ERBB2, CDH1, CTNNB1
6glutathione transferase activityGO:0043649.1GSTT1, GSTP1, GSTM1
7protein C-terminus bindingGO:0080228.9CTNNB1, ERCC1, ERCC2, ERBB2
8protein bindingGO:0055156.6ERBB2, GSTP1, HNRNPU, XRCC3, ERCC2, ERCC1

Products for genes affiliated with Diffuse Gastric Cancer

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Sources for Diffuse Gastric Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet