MCID: DFF019
MIFTS: 47

Diffuse Gastric Cancer malady

Gastrointestinal, Cancer categories

Summaries for Diffuse Gastric Cancer

Sources:
43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Diffuse gastric cancer is a type of cancer found most often in the glandular cells lining the stomach, but can also develop in the bowel, breast, pancreas, bladder, prostate or lung. the term "signet ring cell" is often used because the cells look like signet rings when viewed under a microscope. the signet cells are a type of epithelial cell. epithelial tissue is skin tissue, covering and lining the body both inside and out.  last updated: 12/16/2011

MalaCards: Diffuse Gastric Cancer, also known as signet ring cell gastric carcinoma, is related to hereditary diffuse gastric cancer and bladder carcinoma. An important gene associated with Diffuse Gastric Cancer is CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), and among its related pathways are Glioma and S-1P Stimulated Signaling. The compounds erlotinib and chi 2 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and colon, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

Aliases & Classifications for Diffuse Gastric Cancer

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Aliases & Descriptions:

diffuse gastric cancer 43
signet ring cell gastric carcinoma 43
signet ring gastric carcinoma 43
carcinoma, signet ring cell 61
signet cell adenocarcinoma 43
signet ring cell carcinoma 43


Related Diseases for Diffuse Gastric Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Diffuse Gastric Cancer family:

gastric cancer, familial diffuse, with or without cleft lip and/or palate

Diseases related to Diffuse Gastric Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary diffuse gastric cancer31.6CDH1
2bladder carcinoma31.0CDH1, ERBB2, GSTT1
3basal cell carcinoma30.4XRCC3, CDH3, ERCC1, ERCC2, GSTT1
4gastric cancer risk after h. pylori infection30.3IL1B, IL1RN
5cleft palate30.3MTR, FGFR2
6stomach cancer30.3CASP10, IRF1, MUTYH, KRAS
7adenoma30.3MTR, MUTYH, CDH1, CDH3, KRAS, ERCC1
8squamous cell carcinoma30.3ERBB2, ERCC1, KRAS, FGFR2, CDH3, CDH1
9gastric cancer, somatic30.1KLF6, CASP10, IRF1, PIK3CA, MUTYH, FGFR2
10transitional cell carcinoma30.1CDH1, FGFR2, ERBB2, GSTT1, GSTP1
11adenocarcinoma30.1KLF6, XRCC3, IRF1, PIK3CA, CDH1, CDH3
12signet ring cell adenocarcinoma10.9
13mucinous adenocarcinoma10.7
14cardiac tamponade10.5
15neuroendocrine carcinoma10.5
16bile duct signet ring cell carcinoma10.5
17pancreatic signet ring cell adenocarcinoma10.5
18gastric signet ring cell adenocarcinoma10.5
19bladder signet ring cell adenocarcinoma10.5
20bladder adenocarcinoma10.5
21prostate signet ring cell adenocarcinoma10.4
22ampullary signet ring cell adenocarcinoma10.4
23small cell carcinoma10.4
24colon signet ring adenocarcinoma10.4
25tubular adenocarcinoma10.4
26colon mucinous adenocarcinoma10.4
27eye carcinoma10.3
28signet ring basal cell carcinoma10.3
29erysipelas10.3
30clear cell adenocarcinoma10.3
31gallbladder signet ring cell adenocarcinoma10.3
32breast signet ring cell adenocarcinoma10.3
33pleomorphic carcinoma10.3
34meckel's diverticulum10.3
35gastric lymphoma10.3
36gastric small cell carcinoma10.3
37gastric tubular adenocarcinoma10.3
38thrombotic thrombocytopenic purpura10.3
39lung lymphoma10.3
40barrett's esophagus10.3
41gastrointestinal stromal tumor10.3
42gastric squamous cell carcinoma10.3
43spindle cell carcinoma10.3
44eyelid carcinoma10.3
45burkitt's lymphoma10.3
46mucinous stomach adenocarcinoma10.3
47zollinger-ellison syndrome10.3
48adenoid cystic carcinoma10.3
49large cell carcinoma10.3
50appendix adenocarcinoma10.3

Graphical network of the top 20 diseases related to Diffuse Gastric Cancer:



Diseases related to diffuse gastric cancer

Clinical Features for Diffuse Gastric Cancer

Drugs & Therapeutics for Diffuse Gastric Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diffuse Gastric Cancer

Drug clinical trials:

Search ClinicalTrials for Diffuse Gastric Cancer

Search NIH Clinical Center for Diffuse Gastric Cancer

Search CenterWatch for Diffuse Gastric Cancer

Genetic Tests for Diffuse Gastric Cancer

Anatomical Context for Diffuse Gastric Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Diffuse Gastric Cancer:

33
Bone marrow, Spleen, Colon, Liver, Lung, Pancreas, Breast, Skin, Prostate, Fetal liver, Pancreatic islet

Animal Models for Diffuse Gastric Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Diffuse Gastric Cancer

Sources:
51PubMed
See all sources

Articles related to Diffuse Gastric Cancer:

(show top 50)    (show all 140)
idTitleAuthorsYear
1
Clinical utility gene card for: Hereditary diffuse gastric cancer (HDGC). (23443028)
2013
2
MSI1 overexpression in diffuse type of gastric cancer. (23164718)
2013
3
Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. (23812922)
2013
4
Diffuse gastric cancer with peritoneal carcinomatosis can mimic Crohn's disease. (23185152)
2012
5
CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. (22020549)
2012
6
Catenin family genes are not commonly mutated in hereditary diffuse gastric cancer. (23071139)
2012
7
Hereditary diffuse gastric cancer: strategies to reduce tumoral risk. (22738705)
2012
8
Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer. (21276134)
2011
9
Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer. (21271559)
2011
10
The identification and management of hereditary diffuse gastric cancer in a large Jordanian family. (21681551)
2011
11
A functional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. (21070779)
2011
12
Prophylactic total gastrectomy for hereditary diffuse gastric cancer. Review of the literature. (21872467)
2011
13
Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment. (21345767)
2011
14
Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population. (21064099)
2011
15
The sex ratio and age of onset features of gastric cancer patients in hereditary diffuse gastric cancer families. (21594699)
2011
16
CDH1 gene mutations do not contribute in hereditary diffuse gastric cancer in Poland. (20842455)
2010
17
SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility. (20549826)
2010
18
A novel truncating mutation in the E-cadherin gene in the first Iranian family with hereditary diffuse gastric cancer. (20471195)
2010
19
Hereditary diffuse gastric cancer due to a previously undescribed CDH1 splice site mutation. (20624523)
2010
20
Hereditary diffuse gastric cancer. (20517687)
2010
21
Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. (20591882)
2010
22
Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population. (20131315)
2010
23
Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-beta-dependent mechanism in diffuse-type gastric cancer cells. (20144860)
2010
24
Hereditary diffuse gastric cancer: lifesaving total gastrectomy for CDH1 mutation carriers. (20591881)
2010
25
Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. (19408054)
2009
26
Hereditary diffuse gastric cancer: a manifestation of lost cell polarity. (19432899)
2009
27
Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer. (19247957)
2009
28
Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. (17513507)
2008
29
Endogastric capsule for E-cadherin gene (CDH1) promoter hypermethylation assessment in DNA from gastric juice of diffuse gastric cancer patients. (17986624)
2008
30
Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk. (18825658)
2008
31
Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. (18559507)
2008
32
Hereditary diffuse gastric cancer associated with E-cadherin mutation: penetrance after all. (18989144)
2008
33
Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer. (18788075)
2008
34
Presence of poorly differentiated component correlated with submucosal invasion in the early diffuse-type gastric cancer. (19260519)
2008
35
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. (18488030)
2008
36
Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. (17273778)
2007
37
E-cadherin and hereditary diffuse gastric cancer. (17981184)
2007
38
Prophylactic laparoscopic-assisted total gastrectomy for hereditary diffuse gastric cancer. (17651578)
2007
39
Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family. (17126523)
2007
40
A short guide to hereditary diffuse gastric cancer. (19725995)
2007
41
Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer. (16353194)
2006
42
Interleukin 1B gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in Helicobacter pylori-negative gastric cancer of intestinal and diffuse histotype. (15851404)
2005
43
Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. (15102685)
2004
44
Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. (15235021)
2004
45
Clinical implications of E-cadherin associated hereditary diffuse gastric cancer. (15138199)
2004
46
A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer. (12920089)
2003
47
Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. (10973239)
2000
48
Analysis of E-cadherin in diffuse-type gastric cancer using a mutation-specific monoclonal antibody. (10595908)
1999
49
Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. (10433926)
1999
50
Hereditary Diffuse Gastric Cancer (20301318)
1993

Genetic Variations for Diffuse Gastric Cancer

Expression for genes affiliated with Diffuse Gastric Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diffuse Gastric Cancer

Search GEO for disease gene expression data for Diffuse Gastric Cancer.

Pathways for genes affiliated with Diffuse Gastric Cancer

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 50PharmGKB, 56SinoBiological, 60Tocris Bioscience, 12EMD Millipore, 54Reactome, 53R&D Systems
See all sources

Pathways related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0KRAS, FGFR2
210.0CDH3, CDH1, CASP10
39.9XRCC3, ERCC2
49.9CASP10, CDH1, ERBB2
59.8PIK3CA, CDH1, FGFR2
6
Hide members
9.8FGFR2, PIK3CA, CASP10
7
Immune response Bacterial infections in normal airways
Hide members
9.8IRF1, IL1RN, IL1B
89.8ERBB2, CDH1, PIK3CA
9
Immune response IFN gamma signaling pathway
Hide members
9.8IL1B, PIK3CA, IRF1
10
Hide members
9.8KRAS, FGFR2, PIK3CA
119.8ERBB2, KRAS, FGFR2
12
Hide members
9.8PIK3CA, IL1RN, IL1B
13
Hide members
9.8PIK3CA, KRAS, ERBB2
149.6GSTP1, GSTT1
15
Hide members
9.6CASP10, PIK3CA, IL1B, KRAS
16
Hide members
9.6ERBB2, KRAS, CDH1, PIK3CA
17
Hide members
9.6PIK3CA, CDH1, KRAS, ERBB2
189.6ERBB2, KRAS, PIK3CA, CASP10
19
Hide members
9.5KRAS, IL1B, IL1RN, PIK3CA
20
Hide members
9.5PIK3CA, FGFR2, KRAS, ERBB2
21
Hide members
9.5ERBB2, KRAS, FGFR2, PIK3CA
22
Hide members
9.5ERBB2, KRAS, FGFR2, PIK3CA
23
Hide members
9.4IRF1, PIK3CA, IL1RN, IL1B, KRAS
24
Development Prolactin receptor signaling
Hide members
9.3IRF1, PIK3CA, IL1RN, KRAS, ERBB2
25
Hide members
9.3ERBB2, FGFR2, CDH1, CCL8
26
Hide members
9.1ERBB2, CASP10, PIK3CA, FGFR2, IL1B, KRAS
27
Hide members
9.0CASP10, IRF1, PIK3CA, CDH1, FGFR2, IL1RN
288.9PIK3CA, CDH1, FGFR2, KRAS, ERBB2, GSTP1
29
Hide members
8.9CCL8, CASP10, CDH1, FGFR2, IL1B, ERBB2
30
Hide members
8.7CCL8, CASP10, CDH1, CDH3, FGFR2, IL1B

Compounds for genes affiliated with Diffuse Gastric Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1erlotinib45 50 1112.0PIK3CA, CDH1, KRAS, ERBB2
2chi 2459.9CDH1, IL1RN, GSTT1
3creatinine459.9GSTT1, IL1RN, CDH1
4gefitinib45 50 1111.9PIK3CA, CDH1, KRAS, ERBB2
5vitamin d459.8ERBB2, KRAS, FGFR2
6platinum compounds509.8GSTP1, ERCC2, ERCC1
7vinorelbine45 1110.7ERCC2, ERBB2, ERCC1
8o6-methylguanine459.6GSTP1, KRAS, CDH1
9p002459.6CDH1, IL1RN, KRAS, ERBB2, GSTT1
10peptidoglycan45 2910.6CCL8, PIK3CA, IL1RN, IL1B
11p003459.6XRCC3, CDH1, IL1RN, GSTT1
12adriamycin459.5GSTP1, IRF1
13tamoxifen45 50 29 1112.5IRF1, PIK3CA, CDH1, FGFR2, ERBB2
14oxygen45 2410.5KRAS, FGFR2, MTR, IRF1
15h2o2459.5PIK3CA, MUTYH, FGFR2, IL1RN, KRAS, ERBB2
16melphalan45 1110.4XRCC3, ERCC1, ERCC2, GSTP1
17phosphotyrosine459.4HNRNPU, PIK3CA, CDH1, FGFR2, ERBB2
18aspirin45 50 29 2412.4CDH1, IL1RN, IL1B, ERBB2, GSTP1
19rapamycin459.4PIK3CA, CDH1, FGFR2, KRAS, ERCC1, ERBB2
20bcnu459.4ERCC1, ERCC2, GSTT1, GSTP1
21platinum45 5010.4GSTP1, GSTT1, ERCC2, ERCC1
22agar459.4PIK3CA, CDH1, FGFR2, ERBB2, GSTP1
23carboplatin45 50 1111.3ERCC1, ERBB2, GSTT1, GSTP1
24paraffin459.3CDH1, CDH3, FGFR2, KRAS, ERBB2, GSTP1
25serine459.2KLF6, CASP10, IRF1, PIK3CA, CDH1, IL1RN
26n acetylcysteine459.2XRCC3, CDH1, FGFR2, IL1B, ERBB2, GSTP1
27nitric oxide45 11 2411.2KLF6, IRF1, PIK3CA, MTR, CDH3, IL1RN
28hydrocarbons459.2ERCC2, GSTT1, GSTP1
29irinotecan45 50 1111.2CDH1, KRAS, ERCC1, ERBB2, ERCC2, GSTP1
30genistein45 29 60 2 11 2414.2PIK3CA, CDH1, FGFR2, IL1B, ERBB2, GSTP1
31adenylate459.1KLF6, IRF1, PIK3CA, CDH1, FGFR2, IL1RN
32docetaxel45 50 60 1112.1PIK3CA, CDH1, ERCC1, ERBB2, ERCC2, GSTP1
33heparin45 29 11 2412.1HNRNPU, CCL8, PIK3CA, CDH1, IL1RN, ERBB2
34valine459.1MTR, KRAS, ERBB2, GSTT1, GSTP1
35phosphatidylinositol459.0IRF1, PIK3CA, CDH1, FGFR2, IL1RN, KRAS
36thymidylate459.0MTR, CDH1, ERCC1, ERBB2, ERCC2, GSTP1
37progesterone45 60 29 11 2413.0CCL8, PIK3CA, CDH1, CDH3, FGFR2, IL1RN
38oxaliplatin45 50 1111.0KRAS, ERCC1, ERBB2, ERCC2, GSTT1, GSTP1
39cyclophosphamide45 50 1110.9FGFR2, ERCC1, ERBB2, ERCC2, GSTT1, GSTP1
40etoposide45 50 60 1111.9IRF1, PIK3CA, CDH1, ERCC1, ERBB2, GSTT1
41retinoic acid45 249.9IRF1, PIK3CA, CDH1, FGFR2, IL1RN, IL1B
42doxorubicin45 50 1110.8PIK3CA, CDH1, FGFR2, ERCC1, ERBB2, GSTT1
43arginine458.8IRF1, PIK3CA, CDH1, FGFR2, ERBB2, GSTT1
44paclitaxel45 50 1110.7PIK3CA, CDH1, FGFR2, KRAS, ERCC1, ERBB2
455fluorouracil458.7PIK3CA, CDH1, FGFR2, KRAS, ERCC1, ERBB2
46folate458.7XRCC3, MTR, CDH1, ERBB2, ERCC2, GSTT1
47methotrexate45 50 1110.6MTR, CDH1, IL1RN, IL1B, ERCC1, ERBB2
48vegf458.2PIK3CA, CDH1, FGFR2, IL1RN, IL1B, KRAS
49tyrosine458.2HNRNPU, CCL8, IRF1, PIK3CA, CDH3, FGFR2
50cisplatin45 50 60 1110.5GSTP1, CASP10, XRCC3, PIK3CA, MTR, CDH1

GO Terms for genes affiliated with Diffuse Gastric Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1UV protectionGO:00965010.0ERCC1, ERCC2
2multicellular organism growthGO:0352649.8ERCC2, ERCC1, FGFR2
3positive regulation of protein phosphorylationGO:0019349.8ERBB2, KRAS, IL1B
4regulation of ERK1 and ERK2 cascadeGO:0703729.8GSTP1, ERBB2, FGFR2
5cytokine-mediated signaling pathwayGO:0192219.8KLF6, IRF1, IL1B, KRAS
6fibroblast growth factor receptor signaling pathwayGO:0085439.8ERBB2, KRAS, FGFR2, PIK3CA
7Fc-epsilon receptor signaling pathwayGO:0380959.8PIK3CA, FGFR2, KRAS, ERBB2
8epidermal growth factor receptor signaling pathwayGO:0071739.7PIK3CA, FGFR2, KRAS, ERBB2
9embryonic organ developmentGO:0485689.6FGFR2, ERCC1
10neurotrophin TRK receptor signaling pathwayGO:0480119.5PIK3CA, FGFR2, KRAS, ERBB2
11positive regulation of transcription, DNA-dependentGO:0458939.5ERCC2, IL1B, CDH1, IRF1, KLF6
12apoptotic processGO:0069159.4CASP10, IRF1, CDH1, FGFR2, IL1B, ERCC2
13innate immune responseGO:0450879.3ERBB2, KRAS, FGFR2, PIK3CA, CASP10
14DNA repairGO:0062819.3ERCC2, ERCC1, MUTYH, XRCC3

Molecular functions related to Diffuse Gastric Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.0IL1B, IL1RN
2protein bindingGO:0055156.8GSTP1, HNRNPU, CASP10, XRCC3, IRF1, PIK3CA

Products for genes affiliated with Diffuse Gastric Cancer

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Sources for Diffuse Gastric Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet