DLBCL
MCID: DFF005
MIFTS: 63

Diffuse Large B-Cell Lymphoma (DLBCL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Diffuse Large B-Cell Lymphoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A b-cell lymphocytic neoplasm that is a cancer of b cells presenting as an aggressive tumour which can arise in virtually any part of the body.

MalaCards: Diffuse Large B-Cell Lymphoma, also known as large b cell diffuse lymphoma, is related to gastric lymphoma and central nervous system lymphoma. An important gene associated with Diffuse Large B-Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are MicroRNAs in cancer and Lymphocyte Signaling. The compounds paraffin and cytidine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Diffuse Large B-Cell Lymphoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
diffuse large b-cell lymphoma:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

diffuse large b-cell lymphoma 8 10 48 30 60
large b cell diffuse lymphoma 42
dlbcl 48


External Ids:

Disease Ontology8 DOID:0050745
MESH via Orphanet35 D016403
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet57 109969005, 46732000
UMLS via Orphanet61 C0079744

Related Diseases for Diffuse Large B-Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases in the Diffuse Large B-Cell Lymphoma family:

Lymphoma, Diffuse Large Cell

Diseases related to Diffuse Large B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1gastric lymphoma31.5MALT1, BCL6
2central nervous system lymphoma31.5BCL6
3leukemia31.2PAX5, CDKN2A, CASP3, IRF4, GAPDH, PIM1
4anaplastic large cell lymphoma31.1BCL6, PAX5
5burkitt's lymphoma31.0BCL6, PAX5, MYC, CASP3
6chronic lymphocytic leukemia31.0CASP3, CD5, PAX5, BCL6
7hodgkin's lymphoma30.9PRDM1, BCL6, PAX5, IRF4
8macroglobulinemia30.9CD5, PAX5
9rheumatoid arthritis30.9CD5
10hepatitis c30.8PAX5
11t-cell leukemia30.7IRF4, MYC, LMO2, CASP3
12sarcoma30.7GAPDH
13myeloid leukemia30.6CASP3, PIM1, MYC
14prolymphocytic leukemia30.6MYC, CD5
15myeloma30.4MYC, PRDM1, IRF4, PAX5, CASP3, BCL6
16non-hodgkin lymphoma30.4MALT1, MYC, PAX5, IRF4, CD5, BCL6
17lymphoma, diffuse large cell30.4BCL6, MYC, PRDM1, PAX5
18reticulosarcoma30.4PAX5, CASP3, BCL6
19multiple myeloma30.4IRF4, CDKN2A
20acute leukemia30.4PAX5, LMO2
21bone lymphoma11.0
22mediastinitis10.8
23composite lymphoma10.8
24testicular lymphoma10.7
25hepatitis b10.7
26adult lymphoma10.7
27mantle cell lymphoma10.7
28hepatitis10.7
29breast lymphoma10.7
30gastrointestinal lymphoma10.6
31lymphoplasmacytic lymphoma10.6
32marginal zone b-cell lymphoma10.6
33lung lymphoma10.6
34orbit lymphoma10.6
35pediatric lymphoma10.6
36hepatitis a10.6
37arthritis10.6
38hemolytic anemia10.6
39autoimmune hemolytic anemia10.6
40neutropenia10.6
41diffuse large b-cell lymphoma of the central nervous system10.6
42diffuse large b-cell lymphoma with chronic inflammation10.6
43pure red-cell aplasia10.5
44colon lymphoma10.5
45richter's syndrome10.5
46thyroid lymphoma10.5
47hypercalcemia10.5
48retroperitoneal lymphoma10.5
49b cell deficiency10.5
50cutaneous t cell lymphoma10.5

Graphical network of the top 20 diseases related to Diffuse Large B-Cell Lymphoma:



Diseases related to diffuse large b-cell lymphoma

Clinical Features for Diffuse Large B-Cell Lymphoma

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Drugs & Therapeutics for Diffuse Large B-Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Diffuse Large B-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Diffuse Large B-Cell Lymphoma

Search NIH Clinical Center for Diffuse Large B-Cell Lymphoma

Search CenterWatch for Diffuse Large B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diffuse Large B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Diffuse Large B-Cell Lymphoma

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Anatomical Context for Diffuse Large B-Cell Lymphoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Diffuse Large B-Cell Lymphoma:

32
B cells, T cells, Bone, Bone marrow, Breast, Endothelial, Lung, Monocytes, Spleen, Testis, Skin, Thyroid, Liver, Pituitary, Colon, Spinal cord, Prostate, Smooth muscle, Myeloid, Lymph node, B lymphoblasts, Nk cells, Tonsil, Small intestine, Heart, Brain, Kidney, Uterus, Thymus, Occipital lobe

Animal Models for Diffuse Large B-Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diffuse Large B-Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.0PRDM1, GAPDH, BCL6, IRF4, CASP3, PAX5
2MP:000538711.8PAX5, LMO2, CDKN2A, MYC, MALT1, PRDM1
3MP:000538411.7BCL6, CASP3, PAX5, CDKN2A, CD5, MYD88
4MP:000537811.6LMO2, CDKN2A, MYD88, MYC, PIM1, PRDM1
5MP:000301211.0CD5, CDKN2A, MYD88, MYC, PRDM1, PIM1

Publications for Diffuse Large B-Cell Lymphoma

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Sources:
50PubMed
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Articles related to Diffuse Large B-Cell Lymphoma:

(show top 50)    (show all 1400)
idTitleAuthorsYear
1
Impact of occult bone marrow involvement on the outcome of rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone therapy for diffuse large B-cell lymphoma. (23566159)
2013
2
Pregnancy and cavernous sinus syndrome in diffuse large B-cell lymphoma. (23771377)
2013
3
Diffuse large B-cell lymphoma associated with chronic inflammation in metallic implant. (23401446)
2013
4
Posterior reversible encephalopathy after intrathecal methotrexate therapy in diffuse large B-cell lymphoma. (23617825)
2013
5
Genetic association of interleukin-10 promoter polymorphisms and susceptibility to diffuse large B-cell lymphoma: a meta-analysis. (23485354)
2013
6
MYC rearrangements are useful for predicting outcomes following rituximab and chemotherapy: multicenter analysis of Japanese patients with diffuse large B-cell lymphoma. (23363269)
2013
7
PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma. (23840064)
2013
8
Predictive value of [(18)F]fluoro-2-deoxy-d-glucose positron emission tomography for clinical outcome in patients with relapsed/refractory diffuse large B-cell lymphoma prior to and after autologous stem cell transplant. (23617323)
2013
9
Mutation mismatch repair gene deletions in diffuse large B-cell lymphoma. (23066952)
2013
10
Immunoglobulin heavy chain/light chain pair measurement is associated with survival in diffuse large B-cell lymphoma. (23327290)
2013
11
Prognostic factors of primary gastric diffuse large B cell lymphoma: a retrospective study of 75 cases in China. (23238898)
2013
12
Clinicopathological study of gene rearrangement and microRNA expression of primary central nervous system diffuse large B-cell lymphomas. (24133582)
2013
13
Low incidence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly in Tianjin, northern China. (22830615)
2013
14
Phase III study of ACVBP versus ACVBP plus rituximab for patients with localized low-risk diffuse large B-cell lymphoma (LNH03-1B). (23235801)
2013
15
Lymphopenia following the completion of first-line therapy predicts early relapse in patients with diffuse large B cell lymphoma. (21811783)
2012
16
Secondary cutaneous Epstein-Barr virus-associated diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma: a case report and review of literature. (22260632)
2012
17
Diffuse pulmonary uptake on FDG-PET with normal CT diagnosed as intravascular large B-cell lymphoma: a case report and a discussion of the causes of diffuse FDG uptake in the lungs. (22275725)
2012
18
Spontaneous Regression of Primary Diffuse Large B-Cell Lymphoma, Leg Type. (23098572)
2012
19
Intravascular large B-cell lymphoma with diffuse FDG uptake in the lung by 18FDG-PET/CT without chest CT findings. (22539250)
2012
20
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
21
Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. (21173233)
2011
22
Sequential development of histiocytic sarcoma and diffuse large b-cell lymphoma in a patient with a remote history of follicular lymphoma with genotypic evidence of a clonal relationship: a divergent (bilineal) neoplastic transformation of an indolent B-cell lymphoma in a single individual. (21317718)
2011
23
Prognostic value of immunohistochemical classification of diffuse large B-cell lymphoma into germinal center B-cell and non-germinal center B-cell subtypes. (20174727)
2010
24
An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas. (20664054)
2010
25
Nodular, lymphocyte-predominant Hodgkin lymphoma: a long-term study and analysis of transformation to diffuse large B-cell lymphoma in a cohort of 164 patients from the Adult Lymphoma Study Group. (20029973)
2010
26
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. (20054396)
2010
27
Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapy. (19223503)
2009
28
Aberrations of the MYC gene in unselected cases of diffuse large B-cell lymphoma are rare and unpredictable by morphological or immunohistochemical assessment. (19638549)
2009
29
Differences in germinal centre and non-germinal center phenotype in gastric and intestinal diffuse large B-cell lymphomas. (18798105)
2008
30
Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib. (18596745)
2008
31
Detection of 3q27 chromosomal abnormality in diffuse large B cell lymphoma using FISH on cell microarray]. (18247310)
2008
32
Prognostic impact of tumor infiltrating FOXP3 positive regulatory T cells in diffuse large B-cell lymphoma at diagnosis. (18231910)
2008
33
Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma. (18367485)
2008
34
A novel t(3;8)(q27;q24.1) simultaneously involving both the BCL6 and MYC genes in a diffuse large B-cell lymphoma. (17175379)
2007
35
Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas. (17325859)
2007
36
A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma. (17705020)
2007
37
Fascin expression in diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and classical Hodgkin lymphoma. (17488159)
2007
38
BCL-6 and rituximab in diffuse large B-cell lymphoma: where are we? (17210865)
2007
39
Extensive organizing pneumonia during chemo-immunotherapy containing rituximab and G-CSF in a patient with diffuse large B-cell lymphoma: case report and review of the literature. (16966286)
2006
40
t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B-cell lymphomas. (16630178)
2006
41
The interleukin-10 gene promoter polymorphism (-1082) does not correlate with clinical outcome in diffuse large B-cell lymphoma. (15933064)
2005
42
Diffuse large B-cell lymphoma occurring in patients with lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia. Clinicopathologic features of 12 cases. (12931555)
2003
43
Prognostic value of GST-pi expression in diffuse large B-cell lymphomas. (12750712)
2003
44
Increased expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas. (12748254)
2003
45
Chromosomal imbalances in diffuse large B-cell lymphoma detected by comparative genomic hybridization. (12181265)
2002
46
Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin A and cyclin B1 in diffuse large B-cell lymphomas. (11706071)
2001
47
Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia. (11699422)
2001
48
Characteristic chromosomal imbalances in primary central nervous system lymphomas of the diffuse large B-cell type. (10668897)
2000
49
Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma. (10086736)
1999
50
De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct. (7541611)
1995

Genetic Variations for Diffuse Large B-Cell Lymphoma

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Expression for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diffuse Large B-Cell Lymphoma

Search GEO for disease gene expression data for Diffuse Large B-Cell Lymphoma.

Pathways for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
29KEGG, 4Cell Signaling Technology, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1paraffin4411.5MALT1, MYC, CDKN2A, PAX5, BCL6, CD5
2cytidine44 11 2413.3PRDM1, MYC, BCL6, PAX5
3cytarabine44 49 1113.3CASP3, MYC, GAPDH, CDKN2A
4mg 13244 5912.3CASP3, GAPDH, CDKN2A, MYC
5agarose4411.3CASP3, CDKN2A, MYC, GAPDH
6imatinib44 49 1113.3BCL6, CASP3, MYC, GAPDH
7arsenite44 2412.2CDKN2A, CASP3, GAPDH, MYC
8n acetylcysteine4411.1GAPDH, MYC, CASP3, CDKN2A
9depsipeptide4411.1CDKN2A, CASP3, MYC
106-hydroxydopamine4411.1GAPDH, CASP3, MYC
11roscovitine4411.1CDKN2A, CASP3, MYC
12daunorubicin44 49 1113.1MYC, CDKN2A, CASP3
13oligonucleotide4411.0PAX5, GAPDH, MYC, MYD88, CDKN2A
14rapamycin4411.0PIM1, MYC, CASP3, GAPDH
15tachyplesin i4411.0MYC, CDKN2A
164-hydroxynonenal44 2412.0MYC, GAPDH, CASP3
17gemcitabine44 49 1113.0CASP3, MYC, GAPDH
18ly2940024410.9MYD88, MYC, GAPDH, CASP3
19trapoxin4410.9GAPDH, MYC
20vincristine44 49 1112.9MYC, BCL6, CDKN2A
21serine4410.9PIM1
22doxorubicin44 49 1112.6BCL6, CASP3, MYC, CDKN2A
23rasagiline44 1111.6GAPDH, CASP3

GO Terms for genes affiliated with Diffuse Large B-Cell Lymphoma

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16Gene Ontology
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Cellular components related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.8BCL6, IRF4, GAPDH, PIM1, PRDM1, MALT1

Biological processes related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306610.7CASP3, PIM1, MALT1, MYC, MYD88
2negative regulation of B cell proliferationGO:03088910.7CDKN2A, PRDM1, CASP3
3negative regulation of cell-matrix adhesionGO:00195310.7CDKN2A, BCL6

Molecular functions related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.8CD5, BCL6, LMO2, CASP3, IRF4, GAPDH
2transcription factor bindingGO:00813410.8IRF4, PIM1, MYC, CDKN2A
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.4CDKN2A, CASP3

Products for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources for Diffuse Large B-Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet