Diffuse Large B-cell Lymphoma malady

Disease Ontology: A b-cell lymphocytic neoplasm that is a cancer of b cells presenting as an aggressive tumour which can arise in virtually any part of the body.⁶

MalaCards: Diffuse Large B-cell Lymphoma, also known as lymphoma, diffuse large b-cell, is related to b-cell lymphomas and follicular lymphoma. An important gene associated with Diffuse Large B-cell Lymphoma is PASD1 (PAS domain containing 1), and among its related pathways are Apoptosis and Autophagy and Lymphocyte Signaling. The drugs mitoxantrone and irinotecan hydrochloride and the compounds threonine and okadaic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are hematopoietic system and growth/size.

diffuse large b-cell lymphoma 6 43 lymphoma, diffuse large b-cell 33

large b cell diffuse lymphoma 30 lymphoma 43

Disease types for diffuse large b-cell lymphoma family:

lymphoma, diffuse large cell

Diseases related to diffuse large b-cell lymphoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1039)

id	Related Disease	Score	Top Affiliating Genes
1	b-cell lymphomas	50.7	PIM1, REL, RB1, NBN, MYC, BIRC3
2	follicular lymphoma	40.3	REL, MYC, BIRC3, PAX5, BCL10, BCL2
3	mantle cell lymphoma	38.7	BCL2, BCL6, ATM, MDM2, CCND1, EZH2
4	burkitt's lymphoma	38.6	MYC, RAG1, BIRC3, BIRC5, PAX5, BCL2
5	leukemia	38.4	PIK3CA, PIK3CG, PIM1, RFX1, NCAM1, PDE4A
6	hodgkin's lymphoma	38.2	PIK3CG, REL, SERPINB9, BRCA1, BRCA2, RAG1
7	adult t-cell leukemia	37.7	PIM1, NCAM1, MYC, PAX5, BCL10, BCL2
8	non-hodgkin lymphoma	37.5	CNR2, NBN, MYC, RAG1, BIRC3, BIRC5
9	malt lymphoma	37.3	MYC, BIRC3, BCL10, BCL2, BCL6, ZAP70
10	peripheral t-cell lymphoma	37.3	NCAM1, PAX5, BCL6, ZAP70, MS4A1, CD5
11	carcinoma	37.2	PIK3CA, PIK3CG, PIM1, NCAM1, PDE4A, REL
12	cutaneous t cell lymphoma	36.4	SELE, BIRC5, BAX, CD5, GZMB, IL15
13	lymphoblastic lymphoma	36.1	LMO2, RAG1, PAX5, BCL6, MS4A1, ENO2
14	acute lymphoblastic leukemia	35.9	KIT, RB1, NBN, LMO2, RAG1, BLNK
15	splenic marginal zone lymphoma	35.6	RELA, BIRC3, PAX5, BCL6, BCR, SDC1
16	mediastinitis	35.4	PIK3CG, REL, KIT, SELE, VEGFC, MYC
17	central nervous system lymphoma	35.3	PIM1, RB1, VEGFA, LPP, MYC, BIRC5
18	marginal zone b-cell lymphoma	35.2	PIM1, RB1, BIRC3, PAX5, BCL10, BCL6
19	chronic lymphocytic leukemia	34.8	PDE4A, REL, BRCA2, BIRC3, BIRC5, PAX5
20	richter's syndrome	34.3	BCR, ATM, CDKN1A, CDKN2A, CD5, IRF4
21	reticulosarcoma	34.1	SERPINB9, PAX5, BCL2, BCL6, LGALS3, B2M
22	leukemia/lymphoma, t-cell	34.0	RB1, NBN, VCAM1, MYC, RAG1, BCL2
23	primary effusion lymphoma	33.6	PIK3CA, VEGFA, MYC, BIRC5, PAX5, BCL2
24	lymphoma, diffuse large cell	33.6	MYC, PAX5, BCL2, BCL2L1, BCL6, MS4A1
25	myeloma	33.5	PIK3CA, PIK3CG, NCAM1, PDE4A, REL, RELA
26	gastric lymphoma	33.4	BCL10, BCL2, BCL6, S100A8, CDKN2A, CD40LG
27	intraocular lymphoma	33.3	BCL2, BCL6, IL10, IL4, IL6, IGHV@
28	lymphomatoid papulosis	33.1	B2M, GZMB, IRF4, FASLG, FAS, CCR4
29	t-cell leukemia	33.0	PIK3CG, REL, RELA, LMO2, VAV1, MYC
30	autoimmune hemolytic anemia	33.0	MYC, CD79A, CD40LG, IL10, IL2, IL2RA
31	breast cancer	32.7	PIK3CA, REL, BRCA1, BRCA2, MYC, MST1R
32	hemolytic anemia	32.7	MYC, CD40LG, IL10, IL2, IL2RA, IL3
33	immunodeficiency	32.7	BCR, LGALS1, CIITA, ZAP70, CFLAR, CD79A
34	hepatitis	32.6	GZMB, MGAT5, IL2RB, FASLG, FAS, IFNA1
35	central nervous system lymphoma, primary	32.3	PIM1, PAX5, BCL6, MGMT, IGHM, DAPK1
36	b-cell non-hodgkin lymphoma	32.2	RB1, VEGFA, MYC, BIRC5, PAX5, KDSR
37	anaplastic large cell lymphoma	32.1	PIK3CA, KIT, RB1, SERPINB9, MYC, BIRC3
38	ataxia telangiectasia	32.1	PIK3CA, PIK3CG, NBN, BRCA1, BRCA2, MYC
39	thyroid lymphoma	32.1	BCL2, CDKN2A, CDK1, IL7R, FAS, CCNB1
40	lymphocytic leukemia	32.0	PIK3CA, PIK3CG, NCAM1, PDE4A, PDE4B, REL
41	multiple myeloma	32.0	PIK3CA, PIK3CG, NCAM1, REL, RELA, KIT
42	neuronitis	32.0	PIK3CA, PIK3CG, PIM1, RFX1, NCAM1, PDE4A
43	lymphosarcoma	31.9	BCL2, BCL6, LGALS1, IL10, IL2RA, MBL2
44	primary malignant lymphoma	31.8	PIK3CA, CDKN2A, IL2RB, IGHM, TP53, PTHLH
45	lymphedema	31.7	VEGFA, VEGFC, VCAM1, MYC, KDR, BCL6
46	ataxia	31.6	PIK3CA, PIK3CG, CNR2, NBN, BRCA1, BRCA2
47	gastrointestinal lymphoma	31.6	NBN, BCL2, CDKN1A, CD44, CCND1, IFI27
48	hypercalcemia	31.5	B2M, IRF4, IL1A, IL1B, IL2, IL2RB
49	pure red-cell aplasia	31.0	CD79A, CD40LG, GZMB, IL2, IL2RA, IL3
50	arthritis	31.0	PIK3CG, PDE4A, REL, RELA, CNR2, KIT

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 asparaginase, cytarabine, cytarabine liposome, doxorubicin hydrochloride, irinotecan, irinotecan hydrochloride, mitoxantrone, mitoxantrone hydrochloride, thiotepa

MalaCards organs/tissues related to diffuse large b-cell lymphoma:

²²

MGI Mouse Phenotypes related to diffuse large b-cell lymphoma:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	15.3	PIM1, KIT, NBN, SERPINB9, BRCA1, BRCA2
2	growth/size phenotype	MP:0005378	13.1	PIK3CA, PIK3CG, PIM1, REL, RELA, KIT
3	embryogenesis phenotype	MP:0005380	12.9	PIK3CA, REL, KIT, NBN, BRCA1, BRCA2
4	mortality/aging	MP:0010768	12.8	PIK3CA, RFX1, NCAM1, PDE4B, REL, RELA
5	nervous system phenotype	MP:0003631	11.9	PDE4A, PDE4B, REL, RELA, KIT, RB1
6	respiratory system phenotype	MP:0005388	11.8	REL, BRCA1, RAG1, BCL6, LEPR, CD14
7	cellular phenotype	MP:0005384	11.8	PIK3CA, PIK3CG, PIM1, NCAM1, PDE4B, REL
8	integument phenotype	MP:0010771	11.7	PIK3CG, REL, RELA, CNR2, KIT, RB1
9	craniofacial phenotype	MP:0005382	11.6	KIT, NBN, RAD23B, LIG4, YBX1, XRCC2
10	immune system phenotype	MP:0005387	11.4	PDE4A, PDE4B, REL, CNR2, KIT, GCSAM
11	homeostasis/metabolism phenotype	MP:0005376	11.2	PIK3CA, PIK3CG, REL, RELA, KIT, RB1
12	renal/urinary system phenotype	MP:0005367	11.1	KIT, BRCA1, LMNA, LMO2, RAG1, BHMT
13	liver/biliary system phenotype	MP:0005370	11.1	REL, KIT, VEGFA, LMO2, RAG1, LIG4
14	endocrine/exocrine gland phenotype	MP:0005379	10.9	NBN, BRCA1, BRCA2, RAD23B, XRCC4, MST1R
15	normal phenotype	MP:0002873	10.9	RELA, SELE, BRCA1, BRCA2, VEGFA, LMNA
16	behavior/neurological phenotype	MP:0005386	10.8	PIK3CA, NCAM1, KIT, RB1, NBN, SELE
17	no phenotypic analysis	MP:0003012	10.7	RB1, VEGFA, VCAM1, MYC, LEPR, UGCG
18	digestive/alimentary phenotype	MP:0005381	10.6	REL, KIT, RB1, BRCA1, BRCA2, VEGFA
19	pigmentation phenotype	MP:0001186	10.6	KIT, RB1, BRCA1, LMNA, MYC, RAG1
20	hearing/vestibular/ear phenotype	MP:0005377	10.5	KIT, RB1, LMNA, MYC, RAG1, PAX5
21	limbs/digits/tail phenotype	MP:0005371	9.9	RELA, KIT, RB1, BRCA1, BRCA2, VEGFA
22	adipose tissue phenotype	MP:0005375	9.7	PIK3CA, RB1, BRCA1, LMNA, MYC, RAD23B
23	cardiovascular system phenotype	MP:0005385	9.3	PIK3CA, PIK3CG, PDE4A, PDE4B, REL, RELA
24	skeleton phenotype	MP:0005390	9.2	PIK3CG, REL, RELA, KIT, RB1, BRCA1
25	reproductive system phenotype	MP:0005389	8.9	PIK3CA, NBN, BRCA1, BRCA2, VEGFA, LMNA
26	muscle phenotype	MP:0005369	8.9	PIK3CA, PIK3CG, RELA, KIT, RB1, BRCA1
27	tumorigenesis	MP:0002006	8.8	PIK3CA, KIT, RB1, NBN, BRCA1, BRCA2
28	vision/eye phenotype	MP:0005391	8.5	PIK3CA, NCAM1, RELA, KIT, RB1, SELE

Articles related to diffuse large b-cell lymphoma:

(show top 50)    (show all 468)

id	Title	Authors	Year	Affiliating Genes
1	Quantitative evaluation of p16(INK4a) promoter methyl ation using pyrosequencing in de novo diffuse large B-cell lymphoma. (21035853)	Zainuddin N.... Rosenquist R.	2011	CDKN2A
2	Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma. (21772273)	Dai B.... Gartenhaus R.B.	2011	MAPK3, CHEK2
3	Increased MYC gene copy number correlates with increa sed mRNA levels in diffuse large B-cell lymphoma. (20378577)	Stasik C.J.... Rimsza L.M.	2010	MYC
4	Inhibition of fatty acid synthase suppresses c-Met re ceptor kinase and induces apoptosis in diffuse large B-cell lymphoma. (20423996)	Uddin S.... Al-Kuraya K.S.	2010	FASN, MST1R
5	Y-box binding protein-1 expression in diffuse large B -cell lymphoma: an impact on prognosis in the rituximab era. (20929326)	Hanzawa K.... Tamaru J.	2010	YBX1
6	Burkitt lymphoma versus diffuse large B-cell lymphoma : a practical approach. (19844983)	Bellan C.... Lorenzo L.	2010	MYC
7	Expressions of bcl-6, lpp and miR-28 genes in diffuse large B cell lymphoma cell lines (19236753)	Xu W.... Shen Q.D.	2009	BCL6, LPP, MIR28
8	CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure. (19211644)	Johnson N.A.... Gascoyne R.D.	2009	MS4A1
9	Hyperactivated STAT3 in ALK-positive diffuse large B-cell lymphoma with clathrin-ALK fusion. (18755494)	Momose S.... Itoyama S.	2009	STAT3, BIRC5, ALK
10	Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population. (18203021)	Al-Dayel F.... Al-Kuraya K.	2008	GSTP1, CYP1A1, GSTT1
11	Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. (17637749)	Takeyama K.... Shipp M.A.	2008	TP53BP1
12	Characterization of three t(3;8)(q27;q24) translocations from diffuse large B-cell lymphomas. (17989722)	Bertrand P.... Bastard C.	2008	MYC, BCL6
13	Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. (17916749)	Cillessen S.A.... Oudejans J.J.	2008	CASP9, XIAP
14	Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. (18400256)	Bavi P.... Al-Kuraya K.S.	2008	CCNH
15	De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients. (18556402)	Yamaguchi M.... Nakamura S.	2008	CD5
16	S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma. (18850583)	Uddin S.... Al-Kuraya K.S.	2008	SKP2
17	ERCC1 Expression in Diffuse Large B-Cell Lymphoma Pat ients Treated with a Cisplatin-Based Regimen : A Brief Communication. (19190690)	Azim H.A.... Peccatori F.A.	2007	ERCC1
18	Germinal Center B Cell-Like (GCB) and Activated B Cell-Like (ABC) Type of Diffuse Large B Cell Lymphoma (DLBCL): Analysis of Molecular Predictors, Signatures, Cell Cycle State and Patient Survival. (19455257)	Blenk S.... Dandekar T.	2007	LMO2
19	Fascin expression in diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and classical Hodgkin lymphoma. (17488159)	Bakshi N.A.... Ross C.W.	2007	FSCN1
20	Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma. (17379744)	Liu Y.Y.... Zhao W.L.	2007	PRDM1
21	The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. (18024371)	Le Gouill S.... Avet-Loiseau H.	2007	MYC
22	Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma. (17179223)	Andreadis C.... Rebbeck T.R.	2007	GPX1
23	PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma. (17657213)	Abubaker J.... Al-Kuraya K.	2007	PTEN, PIK3CA
24	CD40 expression identifies a prognostically favourable subgroup of diffuse large B-cell lymphoma. (17786713)	Linderoth J.... Cavallin-StAYhl E.	2007	CD40, BCL6, FCER2
25	Expression of PLK1 and survivin in diffuse large B-cell lymphoma. (17943598)	Liu L.... Zou P.	2007	PLK1, BIRC5
26	Microvessel density and expression of vascular endothelial growth factor and its receptors in diffuse large B-cell lymphoma subtypes. (17392174)	Gratzinger D.... Natkunam Y.	2007	VEGFA
27	Diffuse large B-cell lymphoma with expression of anaplastic lymphoma kinase protein: clinicopathologic and immunohistochemical study of 5 cases (17134546)	Wang W.Y.... Liao D.Y.	2006	ALK
28	De novo CD5-positive diffuse large B-cell lymphoma associated with autoimmune hemolytic anemia presenting as erythroid hypoplasia (16910573)	Kuroda H.... Niitsu Y.	2006	HP
29	Comparison of the expression and prognostic significance of differentiation markers between diffuse large B-cell lymphoma of central nervous system origin and peripheral nodal origin. (16489068)	Lin C.H.... Cheng A.L.	2006	BCL6
30	Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. (16424392)	Tam W.... Knowles D.M.	2006	PRDM1
31	Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival. (16946303)	Uddin S.... Al-Kuraya K.S.	2006	XIAP
32	Transformed diffuse large B-cell lymphomas with gains of the discontinuous 12q12-14 amplicon display concurrent deregulation of CDK2, CDK4 and GADD153 genes. (16704435)	Al-Assar O.... Hancock B.W.	2006	CDK4, CDK2
33	Extensive organizing pneumonia during chemo-immunotherapy containing rituximab and G-CSF in a patient with diffuse large B-cell lymphoma: case report and review of the literature. (16966286)	Mian M.... Greil R.	2006	CSF3
34	Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis. (15920553)	Berglund M.... Enblad G.	2005	IRF4
35	Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas. (15586235)	Ramuz O.... Xerri L.	2005	TCL1A
36	Immunohistochemical expression of multidrug resistance proteins as a predictor of poor response to chemotherapy and prognosis in patients with nodal diffuse large B-cell lymphoma. (16020972)	Ohsawa M.... Ueda M.	2005	MVP
37	Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma. (15480422)	Kameoka Y.... Seto M.	2004	FHIT
38	Intensive chemotherapy in the treatment of aggressive diffuse large B-cell lymphoma: malignant lymphoma. (15456955)	AvilAcs A.... Huerta-GuzmA!n J.	2004	CSF3
39	Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma. (14719066)	Chen P.M.... Liu J.H.	2004	FHIT
40	Serologic detection of diffuse large B-cell lymphoma-associated antigens. (15122589)	Liggins A.P.... Banham A.H.	2004	PASD1
41	Clinical significance of intracytoplasmic nm23-H1 expression in diffuse large B-cell lymphoma. (15073128)	Niitsu N.... Hirano M.	2004	IL2RA, NME1
42	Expression of cyclin D3 and cyclin E and identification of distinct clusters of proliferation and apoptosis in diffuse large B-cell lymphomas. (12647795)	Bai M.... Kanavaros P.	2003	RB1, TP53, CCND1
43	HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma. (12509382)	Lossos I.S.... Levy R.	2003	IL4, GCSAM
44	Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma. (11493437)	Lossos I.S.... Levy R.	2001	BCL6
45	Analysis of the immunoglobulin heavy chain gene of secondary diffuse large B-cell lymphoma that subsequently developed in four cases with B-cell chronic lymphocytic leukemia or lymphoplasmacytoid lymphoma (Richter syndrome). (10972862)	Nakamura N.... Abe M.	2000	CD5, IGH@
46	Clinical relevance of the lung resistance protein in diffuse large B-cell lymphomas. (10999723)	Filipits M.... Pirker R.	2000	ABCC1, RPSA
47	Prognostic significance of CD44v6 in diffuse large B-cell lymphoma. (10349995)	Inagaki H.... Eimoto T.	1999	CD44
48	Chromosomal and gene amplification in diffuse large B-cell lymphoma. (9639522)	Rao P.H.... Chaganti R.S.	1998	REL
49	High incidence of BCL-6 gene rearrangement in diffuse large B-cell lymphoma of primary gastric origin. (9283593)	Liang R.... Ho F.C.	1997	BCL6
50	Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study. (8683246)	Kramer M.H.... Kluin P.M.	1996	TP53, BCL2

Genes related to diffuse large b-cell lymphoma according to GeneCards:

(show top 50)    (show all 355)

id	Symbol	Description	Score	GeneCards Section Context
1	PASD1	PAS domain containing 1	11.1	Publications, Expressions, Summaries
2	MIR28	microRNA 28	11.0	Publications
3	PRG1	p53-responsive gene 1	11.0	Publications
4	MIR127	microRNA 127	11.0	Publications
5	BCL6	B-cell CLL/lymphoma 6	11.0	Publications
6	BECN1P1	beclin 1, autophagy related, pseudogene 1	11.0	Publications
7	MIR125B1	microRNA 125b-1	11.0	Publications
8	MIR223	microRNA 223	11.0	Publications
9	MIR155HG	MIR155 host gene (non-protein coding)	11.0	Publications
10	IGHV@	immunoglobulin heavy variable cluster	11.0	Publications
11	MIR17	microRNA 17	11.0	Publications
12	IRF4	interferon regulatory factor 4	11.0	Publications
13	MIRLET7A1	microRNA let-7a-1	11.0	Publications
14	PARP9	poly (ADP-ribose) polymerase family, member 9	11.0	Publications, Expressions
15	MSC	musculin	11.0	Publications
16	PRDM1	PR domain containing 1, with ZNF domain	11.0	Publications
17	CD5	CD5 molecule	11.0	Publications
18	DTX3L	deltex 3-like (Drosophila)	11.0	Publications
19	TBRG1	transforming growth factor beta regulator 1	11.0	Expressions
20	IL9R	interleukin 9 receptor	11.0	Publications
21	XCR1	chemokine (C motif) receptor 1	11.0	Publications
22	SLC7A4	solute carrier family 7 (orphan transporter), member 4	11.0	Publications
23	LMO2	LIM domain only 2 (rhombotin-like 1)	11.0	Publications
24	MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	11.0	Publications
25	TCL1A	T-cell leukemia/lymphoma 1A	11.0	Publications
26	MIR155	microRNA 155	11.0	Publications
27	FCRLA	Fc receptor-like A	11.0	Expressions
28	BCL10	B-cell CLL/lymphoma 10	11.0	Publications
29	MTHFS	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	11.0	Publications
30	MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	11.0	Publications
31	HIC1	hypermethylated in cancer 1	11.0	Publications
32	DUSP5	dual specificity phosphatase 5	11.0	Publications
33	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
34	CIAPIN1	cytokine induced apoptosis inhibitor 1	11.0	Publications
35	CKAP2	cytoskeleton associated protein 2	11.0	Publications
36	IGHM	immunoglobulin heavy constant mu	11.0	Publications
37	REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	11.0	Publications, Functions
38	IGKC	immunoglobulin kappa constant	11.0	Publications
39	MORC4	MORC family CW-type zinc finger 4	11.0	Publications
40	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0	Publications
41	TNIP2	TNFAIP3 interacting protein 2	11.0	Publications
42	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	11.0	Publications
43	CD79B	CD79b molecule, immunoglobulin-associated beta	11.0	Publications
44	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	11.0	Publications
45	S1PR2	sphingosine-1-phosphate receptor 2	11.0	Publications
46	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
47	SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	11.0	Publications
48	SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	11.0	Publications
49	HTRA2	HtrA serine peptidase 2	11.0	Publications
50	CES2	carboxylesterase 2	11.0	Publications

Pathways related to diffuse large b-cell lymphoma according to GeneDecks:

(show top 50)    (show all 309)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and Autophagy3	12.1	PIM1, LMNA, MYC, BIRC3, BIRC5, BCL10
2	Lymphocyte Signaling3	11.8	PIM1, NCAM1, KIT, RAG1, BLNK, PAX5
3	Immune response BCR pathway10	11.5	PIK3CA, REL, RELA, VAV1, BLNK, BCL2L1
4	DNA damage ATM/ATR regulation of G1/S checkpoint10	11.2	REL, NBN, MYC, CHEK2, ATM, CDK2
5	Signal transduction AKT signaling10	11.1	REL, NFKB2
6	Cell cycle Regulation of G1/S transition (part 2)10	11.0	RELA, RB1, CHUK, CDK2, CDK4, MAPK3
7	Development_IGF-1 receptor signaling41	11.0	PIK3CA, REL, RELA, MYC, BCL2L1, CHUK
8	B cell receptor signaling pathway20	10.9	PIK3CA, PIK3CG, RELA, VAV1, BLNK, BCL10
9	Development IGF-RI signaling10	10.9	PIK3CA, REL, RELA, MYC, BCL2L1, CHUK
10	Immune response IL-4 signaling pathway10	10.9	REL, RELA, CHUK, MTOR, FCER2, IL4
11	RAR-Gamma-RXR-Alpha Degradation36	10.8	IL12A, IL15, IL16, IL2, IL21, IL3
12	p53 signaling pathway20	10.7	CHEK2, BAX, ATM, CDKN1A, CDK2, CDKN2A
13	Busulfan Pathway, Pharmacodynamics34	10.6	BNIP3, MYC, BCL2, BCL2L1, CHEK2, XIAP
14	Transcription P53 signaling pathway10	10.6	REL, RELA, VEGFA, CDK2, CDKN2A, APEX1
15	Apoptosis Signaling Pathways37	10.5	BIRC3, BIRC5, BCL2, BCL2L1, BAD, BAK1
16	Apoptosis and survival TNFR1 signaling pathway10	10.5	REL, RELA, BIRC3, CHUK, BAX, XIAP
17	Chronic myeloid leukemia20	10.3	PIK3CA, PIK3CG, RELA, RB1, MYC, BCL2L1
18	Small cell lung cancer20	10.3	PIK3CA, PIK3CG, RELA, RB1, MYC, BIRC3
19	p53 Signaling36	10.3	BRCA1, BCL2, CHEK2, BAX, ATM, CDKN1A
20	Pancreatic Adenocarcinoma36	10.2	KIT, RB1, BRCA2, VEGFC, BIRC5, KDR
21	Immune response_Bacterial infections in normal airways41	10.2	REL, RELA, CHUK, CD14, IL1B, IFNG
22	Apoptosis and survival Apoptotic TNF-family pathways10	10.2	BCL2, BCL2L1, BAX, XIAP, FASLG, FAS
23	Akt Signaling36	10.2	PIK3CG, KIT, VEGFC, CHUK, XCR1, MST1R
24	Cytokine production by Th17 cells in CF (Mouse model)41	10.0	REL, RELA, CHUK, JAK2, CD14, FOXP3
25	NFAT Signaling and Lymphocyte Interactions36	9.9	BCL2, BAX, FCER2, IL12A, IL12B, IL13
26	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.8	BCL2, GZMB, IL15, IL15RA, IL2, IL2RA
27	Intestinal immune network for IgA production20	9.7	CD40LG, CD40, IL10, IL15, IL15RA, IL2
28	Regulation of eIF4 and p70S6K36	9.7	VEGFC, BAX, FIGF, IL12A, IL12B, IL13
29	Toxoplasmosis20	9.6	PIK3CA, PIK3CG, RELA, BIRC3, BCL2, BCL2L1
30	IL-10 Pathway36	9.4	PIM1, MYC, BCL2L1, CD14, IL10, IL10RA
31	PGC1Alpha Pathway36	9.4	BCL2, BAX, IL10RA, IL12A, IL12B, IL13
32	Cellular Apoptosis Pathway36	9.4	KIT, VEGFC, KDR, BCL2, BCL2L1, CHEK2
33	Bladder cancer20	9.3	RB1, VEGFA, VEGFC, MYC, CDKN1A, CDKN2A
34	Endothelin-1 Signaling Pathway36	9.2	KIT, MYC, MST1R, FLT1, FLT4, IL10
35	Rho Family GTPases36	9.0	KIT, VEGFC, KDR, BCL2, BAX, MST1R
36	Colorectal Cancer Metastasis36	8.9	MYC, BIRC5, BCL2L1, BAX, MSH2, CDKN1A
37	Leishmaniasis20	8.8	RELA, JAK2, FCGR2A, FCGR3A, IL10, IL12A
38	Immune response_MIF-mediated glucocorticoid regulation41	8.6	REL, RELA, VCAM1, CHUK, IL2, IL6
39	STAT3 Pathway36	8.6	PIM1, MYC, BCL2, BAX, XCR1, JAK2
40	Antioxidant Action of Vitamin-C36	8.6	KIT, VEGFC, KDR, BCL2, CHUK, BAX
41	Measles20	8.5	PIK3CA, PIK3CG, RELA, CHUK, JAK2, CDK2
42	SOCS Pathway36	8.4	VEGFC, BCL2, BAX, JAK2, FIGF, IL10
43	all-trans-Retinoic Acid Signaling in Brain36	8.4	BCL2, BAX, IL10, IL12A, IL12B, IL13
44	Glucocorticoid Receptor Signaling36	8.2	BCL2, BAX, CDKN1A, IL10, IL10RA, IL12A
45	JAK-STAT Pathway36	8.0	KIT, BRCA1, VEGFC, MYC, KDR, BCL2
46	PEDF Induced Signaling36	8.0	RELA, BCL2, BCL2L1, CHUK, BAX, CFLAR
47	Chagas disease (American trypanosomiasis)20	7.9	PIK3CA, PIK3CG, RELA, CHUK, CFLAR, IL10
48	Influenza A20	7.8	PIK3CA, PIK3CG, RELA, CIITA, JAK2, IL12A
49	Cytokine-cytokine receptor interaction20	7.6	KIT, VEGFA, VEGFC, KDR, LEPR, XCR1
50	Cytokine Network36	7.1	IL10, IL12A, IL12B, IL13, IL15, IL16

Compounds related to diffuse large b-cell lymphoma according to GeneDecks:

(show top 50)    (show all 429)

id	Compound	Score	Top Affiliating Genes
1	threonine32	11.5	REL, NBN, ZAP70, CDKN1B, IL2RB, MAP3K8
2	okadaic acid32 42	12.2	PIK3CA, RELA, RB1, MYC, BCL2, BCL2L1
3	roscovitine32	11.1	PIK3CG, BIRC5, BCL2L1, XIAP, CDK1, MAPK3
4	ionomycin32	11.1	PIM1, VAV1, RAG1, BCL10, CHUK, CDK4
5	cyclophosphamide32 34 9 9	14.1	BCL6, MVP, MS4A1, MBL2
6	estrogen32	11.0	SERPINB9, BRCA1, BRCA2, VEGFC, BNIP3, KDR
7	progesterone32 42 9 18 9	14.9	PIK3CA, NCAM1, PDE4A, KIT, RB1, BRCA1
8	mannose32	10.9	LGALS1, LGALS3, CIITA, CD79A, CD14, CD40
9	camptothecin32 42 9 9	13.8	PIK3CG, RB1, NBN, BRCA1, BRCA2, MYC
10	hyaluronic acid32 18	11.6	MYC, B2M, CD44, CDH1, GZMB, IL13
11	steroid32	10.5	PIK3CA, PDE4A, KIT, RB1, BRCA1, BRCA2
12	benzo(a)pyrene32	10.5	RB1, BRCA1, XRCC1, XPC, CDKN1A, CDK4
13	melphalan32 9 9	12.5	BIRC5, BCL2L1, MVP, XRCC3, CD79A, MGMT
14	biotin32 9 18 9	13.5	RB1, B2M, MSH2, CD79A, CDKN2A, CD40LG
15	phosphotyrosine32	10.4	PIK3CA, PIK3CG, KIT, BRCA1, VAV1, KDR
16	ascorbic acid32 18	11.3	PIK3CG, CHUK, XRCC1, JAK2, CD40LG, CDK4
17	methionine32	10.2	KIT, LGALS1, CD14, CDK1, FHIT, GSTT1
18	fludarabine32 9 9	12.1	BIRC3, BIRC5, BCL2, BCL2L1, ZAP70, BAG1
19	vitamin e succinate32	10.1	VCAM1, MYC, BCL2, BCL2L1, BAX, CDKN1A
20	adpribose32	10.0	PIK3CA, PIK3CG, RB1, BRCA1, BRCA2, BIRC5
21	2-chlorodeoxyadenosine32	10.0	KIT, BIRC5, BCL2, BAX, XIAP, B2M
22	wortmannin32 42	10.8	PIK3CA, PIK3CG, PDE4A, VCAM1, VAV1, LIG4
23	vinblastine32 9 9	11.8	BIRC5, KDR, BCL2, BCL2L1, MVP, BAX
24	formaldehyde32 18	10.8	KIT, RB1, SELE, LGALS3, ZAP70, B2M
25	cytochalasin d32 42	10.7	PIK3CG, SELE, VCAM1, BCR, XPC, JAK2
26	indole-3-carbinol32	9.7	BRCA1, BRCA2, BIRC5, BCL2, BCL2L1, BAX
27	c2ceramide32	9.7	PIK3CG, BCL2L1, CHUK, UGCG, BAX, IL1B
28	adriamycin32	9.7	RB1, BRCA1, BRCA2, MYC, BIRC3, BIRC5
29	quercetin32 42 9 18 9	13.6	PIK3CA, PIK3CG, PIM1, SELE, VCAM1, BIRC5
30	paraffin32	9.5	NCAM1, RELA, KIT, RB1, BRCA1, BRCA2
31	thymidylate32	9.4	RB1, BRCA1, VEGFA, BIRC5, BCL2, BCL2L1
32	hydroxyurea32 9 9	11.4	KIT, NBN, BRCA1, BRCA2, VCAM1, MYC
33	arachidonic acid32 9 18 9	12.4	PIK3CA, NCAM1, PDE4A, VAV1, BCL2L1, MTOR
34	creatinine32	9.3	NCAM1, SELE, LMNA, PAX5, MTHFR, MTR
35	irinotecan32 34 9 9	12.3	KIT, VEGFA, BCL2L1, BAK1, BAX, MTHFR
36	butyrate32	9.0	RB1, MYC, BIRC5, BCL2, BCL2L1, LGALS1
37	arsenite32 18	10.0	PIK3CA, PIK3CG, VEGFA, MYC, BIRC5, BCL2
38	mg 13232 42	9.9	PIK3CG, BRCA1, MYC, BIRC3, BIRC5, KDR
39	peptidoglycan32	8.7	PIK3CA, LPP, CIITA, CHUK, CD14, IL10
40	rantes32	8.5	REL, SELE, VCAM1, CIITA, CHUK, CD14
41	troglitazone32 42 9 9	11.5	PIK3CG, RB1, SELE, VCAM1, BIRC5, BCL2
42	tamoxifen32 34 9 9	11.4	PIK3CA, PDE4A, SELE, SERPINB9, BRCA1, BRCA2
43	polyinosinic-polycytidylic acid32	8.4	SELE, VCAM1, CIITA, CD40, IL10, IL12B
44	pd 98,05932	8.2	PIK3CA, PIK3CG, PDE4A, KIT, RB1, VEGFC
45	simvastatin32 34 42 9 18 9	13.1	SELE, VEGFA, VCAM1, PAX5, KDR, CIITA
46	tgf beta132	7.9	VCAM1, KDR, CDKN1A, CDK2, CDKN1B, CDK4
47	thymidine32 18	8.5	PIK3CA, CNR2, KIT, RB1, BRCA1, BRCA2
48	il-1232	7.3	CD40LG, IL10, IL12B, IL13, IL15, IL1B
49	indomethacin32 9 9	9.1	PDE4A, MYC, BIRC5, KDR, LGALS1, BAK1
50	genistein32 9 18 9	9.3	PIK3CA, PIK3CG, RB1, SELE, BRCA1, BRCA2

Cellular components related to diffuse large b-cell lymphoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	14.2	MDM2, CAMK1, CAMK1D, CASP3, CASP8, CASP9
2	cytoplasm	GO:005737	12.9	STAT6, STAT1, PRKCB, PRDM1, POU2F2, NME1
3	nucleoplasm	GO:005654	11.8	RELA, RB1, NBN, BRCA1, BRCA2, LMNA
4	cytosol	GO:005829	10.7	CCND1, TNIP2, PTEN, PTS, CUL1, NQO1
5	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.4	CCND1, CCND3, CCND2, CCNE1, CDK4, CDK2
6	integral to plasma membrane	GO:005887	10.2	TNFSF10, TNF, HLA-DRB1, HLA-DRA, HLA-DQA1, ALK
7	membrane raft	GO:045121	10.0	TRAF2, TNF, PTPRC, SHH, TLR4, CASP8
8	plasma membrane	GO:005886	10.0	HLA-DQB1, HLA-DRA, HLA-DRB1, TNF, TNFRSF10B, TNFRSF8
9	external side of plasma membrane	GO:009897	9.1	IL4, FASLG, FAS, ANXA5, CCR4, CCR5
10	extracellular region	GO:005576	8.4	TNFSF10, TXN, HP, IFNG, IFNB1, IGKC
11	extracellular space	GO:005615	7.6	IL15RA, CCL3, IFNB1, IFNG, ICAM1, HP

Biological processes related to diffuse large b-cell lymphoma according to GeneDecks:

(show top 50)    (show all 80)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell proliferation	GO:008283	11.6	PIM1, NBN, LIG4, BCL2L1, BAK1, FSCN1
2	DNA repair	GO:006281	11.3	NBN, BRCA1, BRCA2, RAD23B, LIG4, XRCC1
3	activation of pro-apoptotic gene products	GO:008633	11.3	MYC, BCL2, BAD, BAK1, BAX, GZMB
4	G1/S transition of mitotic cell cycle	GO:000082	11.2	RB1, BCL2, CDKN1A, CDK2, CDKN1B, CDKN2A
5	virus-host interaction	GO:019048	11.1	RELA, RB1, VCAM1, BNIP3, KDR, BAX
6	induction of apoptosis by intracellular signals	GO:008629	11.0	BNIP3, MYC, BCL2, BCL2L1, BAD, BAK1
7	neuron apoptotic process	GO:051402	11.0	RB1, BNIP3, LIG4, BCL2, BAX, ATM
8	response to DNA damage stimulus	GO:006974	11.0	BRCA1, MYC, BCL2, BCL6, CHEK2, BAX
9	innate immune response	GO:045087	11.0	PIK3CG, RELA, BCL10, BCL2, BCL2L1, LGALS3
10	response to ethanol	GO:045471	11.0	BCL2, BAK1, S100A8, CDK1, MGMT, IL13
11	T cell costimulation	GO:031295	10.9	PIK3CA, VAV1, MTOR, CD5, MAP3K8, CARD11
12	G1 phase of mitotic cell cycle	GO:000080	10.8	RB1, CDKN1A, CDKN1B, CDKN2A, CDKN1C, CDK4
13	signal transduction	GO:007165	10.8	PDE4A, PDE4B, KIT, VEGFC, BCR, LGALS1
14	induction of apoptosis	GO:006917	10.7	BNIP3, BCL10, BAD, BAX, CDKN1B, CDKN2A
15	regulation of apoptotic process	GO:042981	10.7	BRCA1, LMNA, BIRC5, LGALS1, IL6, FAS
16	response to gamma radiation	GO:010332	10.7	BRCA2, MYC, LIG4, BCL2, CHEK2, BAK1
17	phosphatidylinositol-mediated signaling	GO:048015	10.7	PIK3CA, CHUK, BAD, MTOR, CDKN1B, MDM2
18	induction of apoptosis by extracellular signals	GO:008624	10.6	VAV1, BAD, BAK1, BAX, CFLAR, CD5
19	cellular response to mechanical stimulus	GO:071260	10.6	BNIP3, BCL10, BAD, BAK1, CD40, IL13
20	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.6	REL, RELA, BIRC3, BCL10, LGALS1, CHUK
21	T cell receptor signaling pathway	GO:050852	10.5	PIK3CA, RELA, BCL10, CHUK, ZAP70, MALT1
22	immune response	GO:006955	10.5	RFX1, CNR2, SERPINB9, VAV1, RAG1, CIITA
23	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.5	MYC, BAD, BAX, JAK2, CDKN1B, CDKN2A
24	response to lipopolysaccharide	GO:032496	10.5	CNR2, SELE, S100A8, JAK2, IL12A, IL13
25	double-strand break repair	GO:006302	10.4	NBN, BRCA1, BRCA2, LIG4, CHEK2, XRCC4
26	response to toxin	GO:009636	10.4	BCL2, BAX, CDKN1A, CDK1, CDH1, MGMT
27	cell cycle arrest	GO:007050	10.3	RB1, NBN, MYC, MSH2, ATM, CDKN1A
28	B cell differentiation	GO:030183	10.3	VCAM1, RAG1, BLNK, BCL6, MSH2, CD79A
29	interferon-gamma-mediated signaling pathway	GO:060333	10.3	NCAM1, VCAM1, CIITA, B2M, JAK2, CD44
30	positive regulation of apoptotic process	GO:043065	10.2	BCL6, BAD, BAK1, BAX, ATM, JAK2
31	B cell proliferation	GO:042100	10.2	BCL2, CD79A, CD40LG, CD40, IL10, IFNB1
32	positive regulation of MHC class II biosynthetic process	GO:045348	10.1	CIITA, CD40LG, IL10, IL4, IFNG, TLR4
33	response to drug	GO:042493	10.1	PDE4A, NBN, VEGFC, MYC, BCL2, LGALS1
34	apoptotic process	GO:006915	10.0	PIM1, NBN, BRCA1, LMNA, BNIP3, VAV1
35	toll-like receptor 3 signaling pathway	GO:034138	10.0	RELA, CHUK, CD14, CDK1, MAPK3, TNIP2
36	positive regulation of B cell proliferation	GO:030890	10.0	BCL2, BCL6, CDKN1A, CD40LG, CD40, IL13
37	positive regulation of cell proliferation	GO:008284	9.9	KIT, NBN, VEGFA, VEGFC, MYC, BIRC5
38	cellular response to lipopolysaccharide	GO:071222	9.8	CD14, GSTP1, IL10, IL12B, IL8, CCR5
39	anti-apoptosis	GO:006916	9.8	PIK3CA, RELA, SERPINB9, BNIP3, BIRC3, BIRC5
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.7	RELA, BCL10, CHUK, CD40, IL1B, IL6
41	humoral immune response	GO:006959	9.6	BLNK, PAX5, BCL2, IL6, IFNB1, IFNG
42	positive regulation of T cell proliferation	GO:042102	9.5	VCAM1, IL12A, IL12B, IL15, IL1B, IL21
43	positive regulation of transcription, DNA-dependent	GO:045893	9.3	REL, RELA, RB1, BRCA1, BRCA2, MYC
44	cytokine-mediated signaling pathway	GO:019221	9.3	NCAM1, RELA, KIT, VCAM1, CIITA, BAD
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	VEGFA, MTOR, JAK2, CD44, IL3, IL5
46	response to hypoxia	GO:001666	9.0	VEGFA, VCAM1, BNIP3, BCL2, XRCC1, ATM
47	inflammatory response	GO:006954	9.0	PIK3CG, RELA, CNR2, KIT, SELE, BLNK
48	negative regulation of apoptotic process	GO:043066	8.9	PIK3CG, PIM1, RELA, VEGFA, MYC, KDR
49	negative regulation of cell proliferation	GO:008285	8.8	BCL6, BAK1, JAK2, CDKN1A, CDKN1B, CDKN2A
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.8	RELA, RB1, BRCA1, VEGFA, LMO2, MYC

Molecular functions related to diffuse large b-cell lymphoma according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	12.1	SKP2, SPARC, CUL1, CYBA, DAPK1, TBRG1
2	protein kinase binding	GO:019901	11.2	CCND3, CCND1, TP53, TNIP2, PTEN, PTPRC
3	ATP binding	GO:005524	11.2	ERCC2, TP53, DAPK1, PLK1, NOD2, AKT1
4	single-stranded DNA binding	GO:003697	10.7	ERCC1, ERCC5, MCM7, MLH1, MSH2, XPC
5	identical protein binding	GO:042802	10.5	PTS, TNF, TP63, TP53, NFKBIA, SKP2
6	protein homodimerization activity	GO:042803	10.2	CBS, CAT, ERCC5, PTS, PTPRO, CR2
7	enzyme binding	GO:019899	10.2	TP53, PTEN, NOD2, NOTCH1, NFKBIA, H2AFX
8	tumor necrosis factor receptor binding	GO:005164	10.2	TNFSF13B, TNFSF14, LTA, STAT1, TNFSF10, TNF
9	growth factor activity	GO:008083	8.3	IL5, IL6, IL9, CXCL12, CSF3, HGF
10	cytokine activity	GO:005125	7.4	CSF3, IL2, IL1B, IL1A, IL16, IL15