DLBCL
MCID: DFF005
MIFTS: 63

Diffuse Large B-Cell Lymphoma (DLBCL) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Diffuse Large B-Cell Lymphoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A b-cell lymphocytic neoplasm that is a cancer of b cells presenting as an aggressive tumour which can arise in virtually any part of the body.

MalaCards: Diffuse Large B-Cell Lymphoma, also known as large b cell diffuse lymphoma, is related to gastric lymphoma and central nervous system lymphoma. An important gene associated with Diffuse Large B-Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are MicroRNAs in cancer and Lymphocyte Signaling. The compounds paraffin and cytidine have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Diffuse Large B-Cell Lymphoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
diffuse large b-cell lymphoma:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

diffuse large b-cell lymphoma 8 10 48 30 60
large b cell diffuse lymphoma 42
dlbcl 48


External Ids:

Disease Ontology8 DOID:0050745
MESH via Orphanet35 D016403
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet57 109969005, 46732000
UMLS via Orphanet61 C0079744

Related Diseases for Diffuse Large B-Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases in the Diffuse Large B-Cell Lymphoma family:

Lymphoma, Diffuse Large Cell

Diseases related to Diffuse Large B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1gastric lymphoma31.5MALT1, BCL6
2central nervous system lymphoma31.5BCL6
3leukemia31.2PAX5, CDKN2A, CASP3, IRF4, GAPDH, PIM1
4anaplastic large cell lymphoma31.1BCL6, PAX5
5burkitt's lymphoma31.0BCL6, PAX5, MYC, CASP3
6chronic lymphocytic leukemia31.0CASP3, CD5, PAX5, BCL6
7hodgkin's lymphoma30.9PRDM1, BCL6, PAX5, IRF4
8macroglobulinemia30.9CD5, PAX5
9rheumatoid arthritis30.9CD5
10hepatitis c30.8PAX5
11t-cell leukemia30.7IRF4, MYC, LMO2, CASP3
12sarcoma30.7GAPDH
13myeloid leukemia30.6CASP3, PIM1, MYC
14prolymphocytic leukemia30.6MYC, CD5
15myeloma30.4MYC, PRDM1, IRF4, PAX5, CASP3, BCL6
16non-hodgkin lymphoma30.4MALT1, MYC, PAX5, IRF4, CD5, BCL6
17lymphoma, diffuse large cell30.4BCL6, MYC, PRDM1, PAX5
18reticulosarcoma30.4PAX5, CASP3, BCL6
19multiple myeloma30.4IRF4, CDKN2A
20acute leukemia30.4PAX5, LMO2
21bone lymphoma11.0
22mediastinitis10.8
23composite lymphoma10.8
24testicular lymphoma10.7
25hepatitis b10.7
26adult lymphoma10.7
27mantle cell lymphoma10.7
28hepatitis10.7
29breast lymphoma10.7
30gastrointestinal lymphoma10.6
31lymphoplasmacytic lymphoma10.6
32marginal zone b-cell lymphoma10.6
33lung lymphoma10.6
34orbit lymphoma10.6
35pediatric lymphoma10.6
36hepatitis a10.6
37arthritis10.6
38hemolytic anemia10.6
39autoimmune hemolytic anemia10.6
40neutropenia10.6
41diffuse large b-cell lymphoma of the central nervous system10.6
42diffuse large b-cell lymphoma with chronic inflammation10.6
43pure red-cell aplasia10.5
44colon lymphoma10.5
45richter's syndrome10.5
46thyroid lymphoma10.5
47hypercalcemia10.5
48retroperitoneal lymphoma10.5
49b cell deficiency10.5
50cutaneous t cell lymphoma10.5

Graphical network of the top 20 diseases related to Diffuse Large B-Cell Lymphoma:



Diseases related to diffuse large b-cell lymphoma

Clinical Features for Diffuse Large B-Cell Lymphoma

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Drugs & Therapeutics for Diffuse Large B-Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Diffuse Large B-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Diffuse Large B-Cell Lymphoma

Search NIH Clinical Center for Diffuse Large B-Cell Lymphoma

Search CenterWatch for Diffuse Large B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diffuse Large B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Diffuse Large B-Cell Lymphoma

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Anatomical Context for Diffuse Large B-Cell Lymphoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Diffuse Large B-Cell Lymphoma:

32
B cells, T cells, Bone, Bone marrow, Endothelial, Breast, Lung, Monocytes, Testis, Spleen, Skin, Thyroid, Liver, Colon, Pituitary, B lymphoblasts, Myeloid, Lymph node, Prostate, Spinal cord, Smooth muscle, Occipital lobe, Heart, Small intestine, Thymus, Nk cells, Kidney, Brain, Tonsil, Uterus

Animal Models for Diffuse Large B-Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diffuse Large B-Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.0BCL6, CASP3, IRF4, GAPDH, PIM1, PRDM1
2MP:000538711.8MALT1, PRDM1, PIM1, IRF4, CASP3, MYC
3MP:000538411.7MALT1, PRDM1, PIM1, IRF4, CASP3, MYC
4MP:000537811.6GAPDH, PIM1, PRDM1, MYC, MYD88, CDKN2A
5MP:000301211.0PIM1, PRDM1, MYC, MYD88, CD5, CDKN2A

Publications for Diffuse Large B-Cell Lymphoma

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Sources:
50PubMed
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Articles related to Diffuse Large B-Cell Lymphoma:

(show top 50)    (show all 1400)
idTitleAuthorsYear
1
Frequent copy number variations of PI3K/AKT pathway and aberrant protein expressions of PI3K subunits are associated with inferior survival in diffuse large B cell lymphoma. (24418330)
2014
2
Limited role for surveillance PET-CT scanning in patients with diffuse large B-cell lymphoma in complete metabolic remission following primary therapy. (23807169)
2013
3
Predictive value of interim A^a8,F-FDG-PET/CT for event-free survival in patients with diffuse large B-cell lymphoma homogenously treated in a phase II trial with six cycles of R-CHOP-14 plus pegfilgrastim as first-line treatment. (23880897)
2013
4
Could treatment with R-HCVAD/R-MA as compared to R- CHOP truly result in improved outcomes for patients with high-risk diffuse large B cell lymphoma? - Response to Landsburg etA al. (24329994)
2013
5
A multicentre, phase II trial of ofatumumab monotherapy in relapsed/progressive diffuse large B-cell lymphoma. (24032456)
2013
6
At diagnosis, diffuse large B-cell lymphoma patients show impaired rituximab-mediated NK-cell cytotoxicity. (23400905)
2013
7
Epigenetic approaches for chemosensitization of refractory diffuse large B-cell lymphomas. (24019329)
2013
8
Rituximab use and survival after diffuse large B-cell or follicular lymphoma: a population-based study. (22957852)
2013
9
Peripheral blood lymphocyte/monocyte ratio predicts outcome for patients with diffuse large B cell lymphoma after standard first-line regimens. (24141331)
2013
10
Inhibition of pan-class I phosphatidyl-inositol-3-kinase by NVP-BKM120 effectively blocks proliferation and induces cell death in diffuse large B-cell lymphoma. (23721513)
2013
11
Quality of life more impaired in younger than in older diffuse large B cell lymphoma survivors compared to a normative population: a study from the population-based PROFILES registry. (24318593)
2013
12
The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies. (23869078)
2013
13
Clinical significance of cytogenetic aberrations in bone marrow of patients with diffuse large B-cell lymphoma: prognostic significance and relevance to histologic involvement. (24220305)
2013
14
Features and outcomes of diffuse large B-cell lymphoma of the thyroid in a large contemporary cohort. (23647064)
2013
15
Immunohistochemical analysis of the expression of MAGE-A and NY-ESO-1 cancer/testis antigens in diffuse large B-cell testicular lymphoma. (23680437)
2013
16
The sequence of events in diffuse large B-cell lymphoma. (23950172)
2013
17
Successful treatment of diffuse large B-cell lymphoma with clarithromycin and prednisolone. (23320009)
2012
18
Gene expression-based risk score in diffuse large B-cell lymphoma. (23482333)
2012
19
Paramount prognostic factors that guide therapeutic strategies in diffuse large B-cell lymphoma. (23233611)
2012
20
Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (22997459)
2012
21
Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas. (21638516)
2011
22
Diffuse large B-cell lymphoma with germinal center B-cell phenotype mimicking primary effusion lymphoma. (21220599)
2011
23
Correlation between the expressions of CARMA1 gene and MUM1 and its significance in diffuse large B cell lymphoma]. (21569705)
2011
24
Granulocyte-macrophage colony stimulating factor-induced immune priming of cyclophosphamide, doxorubicin, vincristine, and prednisone with rituximab chemoimmunotherapy in previously untreated patients with diffuse large B-cell lymphoma and mantle cell lymphoma. (21702643)
2011
25
Human leukocyte antigen class I and II alleles and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. (22125456)
2011
26
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. (20395518)
2010
27
Vav-1 expression correlates with NFI_B activation and CD40-mediated cell death in diffuse large B-cell lymphoma cell lines. (20155735)
2010
28
Multiple bone lesions and hypercalcemia presented in diffuse large B cell lymphoma: mimicking multiple myeloma? (20379806)
2010
29
Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. (19903857)
2009
30
ABF-1 is frequently silenced by promoter methylation in follicular lymphoma, diffuse large B-cell lymphoma and Burkitt's lymphoma. (18368067)
2008
31
Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome. (19019774)
2008
32
Recent prognostic factors in diffuse large B-cell lymphoma indicate NF-kappaB pathway as a target for new therapeutic strategies. (19021048)
2008
33
Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. (17360630)
2007
34
Persistent anemia in a patient with diffuse large B cell lymphoma: pure red cell aplasia associated with latent Epstein-Barr virus infection in bone marrow. (17923747)
2007
35
Expression of c-FLIP is primarily detected in diffuse large B-cell lymphoma and Hodgkin's lymphoma and correlates with lack of caspase 8 activation. (18042067)
2007
36
Common variable immunodeficiency patient with large granular lymphocytosis developing extranodal diffuse large B-cell lymphoma: a case report. (17194667)
2006
37
Fas and Fas ligand expression on germinal center type-diffuse large B-cell lymphoma is associated with the clinical outcome. (16494623)
2006
38
A 65-year-old woman with a left occipital lobe tumor. Diffuse large B-Cell, primary central nervous system lymphoma. (16740056)
2006
39
Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. (15709173)
2005
40
A case of pure red cell aplasia complicated with diffuse large B cell lymphoma, T-cell-rich/histiocyte-rich variant: effectiveness of rituximab and implications for a common immunopathogenic role of B lymphocytes. (15870490)
2005
41
Diffuse large B-cell primary gastric lymphoma treated successfully with the CD20 monoclonal antibody (rituximab): a case with severe liver dysfunction due to liver cirrhosis and hepatocellular carcinoma. (15870922)
2005
42
Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. (15576477)
2005
43
The interplay between c-Myc oncogene expression and circulating vascular endothelial growth factor (sVEGF), its antagonist receptor, soluble Flt-1 in diffuse large B cell lymphoma (DLBCL): relationship to patient outcome. (15160911)
2004
44
Cluster analysis of apoptosis-associated bcl2 family proteins in diffuse large B-cell lymphomas. Relations with the apoptotic index, the proliferation profile and the B-cell differentiation immunophenotypes. (15517919)
2004
45
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. (12933571)
2003
46
Analysis of immunoglobulin VH genes in CD10-positive diffuse large B-cell lymphoma. (12406188)
2002
47
Analysis of the immunoglobulin heavy chain gene variable region of CD5-positive and -negative diffuse large B cell lymphoma. (11237070)
2001
48
CD10 antigen expression correlates with the t(14;18)(q32;q21) major breakpoint region in diffuse large B-cell lymphoma. (10102615)
1999
49
Diffuse large B-cell lymphoma mainly involving the heart and showing t(8;14) (q24;q32) with c-myc rearrangement]. (9364867)
1997
50
Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study. (8683246)
1996

Genetic Variations for Diffuse Large B-Cell Lymphoma

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Expression for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diffuse Large B-Cell Lymphoma

Search GEO for disease gene expression data for Diffuse Large B-Cell Lymphoma.

Pathways for genes affiliated with Diffuse Large B-Cell Lymphoma

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29KEGG, 4Cell Signaling Technology, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1paraffin4411.5MALT1, MYC, CD5, CDKN2A, PAX5, BCL6
2cytidine44 11 2413.3BCL6, PAX5, MYC, PRDM1
3cytarabine44 49 1113.3CASP3, GAPDH, MYC, CDKN2A
4mg 13244 5912.3CDKN2A, MYC, GAPDH, CASP3
5agarose4411.3CASP3, GAPDH, MYC, CDKN2A
6imatinib44 49 1113.3BCL6, MYC, GAPDH, CASP3
7arsenite44 2412.2CASP3, GAPDH, MYC, CDKN2A
8n acetylcysteine4411.1CASP3, GAPDH, MYC, CDKN2A
9depsipeptide4411.1CASP3, MYC, CDKN2A
106-hydroxydopamine4411.1MYC, GAPDH, CASP3
11roscovitine4411.1CASP3, MYC, CDKN2A
12daunorubicin44 49 1113.1CDKN2A, MYC, CASP3
13oligonucleotide4411.0MYC, MYD88, CDKN2A, PAX5, GAPDH
14rapamycin4411.0CASP3, GAPDH, PIM1, MYC
15tachyplesin i4411.0CDKN2A, MYC
164-hydroxynonenal44 2412.0MYC, GAPDH, CASP3
17gemcitabine44 49 1113.0CASP3, GAPDH, MYC
18ly2940024410.9CASP3, GAPDH, MYC, MYD88
19trapoxin4410.9MYC, GAPDH
20vincristine44 49 1112.9BCL6, CDKN2A, MYC
21serine4410.9PIM1
22doxorubicin44 49 1112.6BCL6, CDKN2A, MYC, CASP3
23rasagiline44 1111.6CASP3, GAPDH

GO Terms for genes affiliated with Diffuse Large B-Cell Lymphoma

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16Gene Ontology
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Cellular components related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.8BCL6, IRF4, GAPDH, PIM1, PRDM1, MALT1

Biological processes related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306610.7CASP3, PIM1, MALT1, MYC, MYD88
2negative regulation of B cell proliferationGO:03088910.7CDKN2A, PRDM1, CASP3
3negative regulation of cell-matrix adhesionGO:00195310.7BCL6, CDKN2A

Molecular functions related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.8IRF4, GAPDH, PIM1, PRDM1, MALT1, MYC
2transcription factor bindingGO:00813410.8CDKN2A, MYC, PIM1, IRF4
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.4CASP3, CDKN2A

Products for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources for Diffuse Large B-Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet