DLBCL
MCID: DFF005
MIFTS: 56

Diffuse Large B-Cell Lymphoma (DLBCL) malady

Blood, Cancer, Immune categories

Summaries for Diffuse Large B-Cell Lymphoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A b-cell lymphocytic neoplasm that is a cancer of b cells presenting as an aggressive tumour which can arise in virtually any part of the body.

MalaCards: Diffuse Large B-Cell Lymphoma, also known as large b cell diffuse lymphoma, is related to lymphoma, diffuse large cell and b-cell lymphomas. An important gene associated with Diffuse Large B-Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are MicroRNAs in cancer and Lymphocyte Signaling. The compounds paraffin and cytidine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and lung, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Diffuse Large B-Cell Lymphoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
diffuse large b-cell lymphoma:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

diffuse large b-cell lymphoma 8 10 49 31 61
large b cell diffuse lymphoma 43
dlbcl 49


External Ids:

Disease Ontology8 DOID:0050745
MESH via Orphanet36 D016403
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet58 109969005, 46732000
UMLS via Orphanet62 C0079744

Related Diseases for Diffuse Large B-Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Diffuse Large B-Cell Lymphoma family:

lymphoma, diffuse large cell diffuse large b-cell lymphoma with chronic inflammation

Diseases related to Diffuse Large B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 190)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell32.7BCL6, MYC, PRDM1, PAX5
2b-cell lymphomas31.6CD5, CDKN2A, CASP3, IRF4, PIM1, PRDM1
3follicular lymphoma31.6MYC, CD5, BCL6, PAX5, IRF4
4gastric lymphoma31.5MALT1, BCL6
5central nervous system lymphoma31.5BCL6
6central nervous system lymphoma, primary31.3PAX5, PIM1, BCL6
7anaplastic large cell lymphoma31.1BCL6, PAX5
8t-cell leukemia31.0IRF4, MYC, LMO2, CASP3
9peripheral t-cell lymphoma31.0PAX5, CD5, BCL6
10hepatitis c31.0PAX5
11macroglobulinemia31.0CD5, PAX5
12burkitt's lymphoma30.9BCL6, PAX5, MYC, CASP3
13lymphoblastic lymphoma30.6PAX5, LMO2, BCL6
14lymphoma, malt, somatic30.4BCL6, IRF4, CD5, MALT1
15reticulosarcoma30.4PAX5, CASP3, BCL6
16acute leukemia30.4PAX5, LMO2
17bone lymphoma11.0
18composite lymphoma10.8
19primary bone lymphoma10.8
20testicular lymphoma10.7
21adult lymphoma10.7
22mantle cell lymphoma10.7
23lymphoma, somatic10.7
24richter's syndrome10.7
25breast lymphoma10.7
26hepatitis d10.7
27n syndrome10.7
28leukemia/lymphoma, t-cell10.7
29hepatitis c virus10.7
30gastrointestinal lymphoma10.7
31lymphoplasmacytic lymphoma10.7
32lung lymphoma10.6
33orbit lymphoma10.6
34pediatric lymphoma10.6
35arthritis10.6
36plasmablastic lymphoma10.6
37hematopoietic stem cell transplantation10.6
38colon lymphoma10.6
39autoimmune hemolytic anemia10.6
40hypoxia10.6
41nodular lymphocyte predominant hodgkin lymphoma10.6
42thyroid lymphoma10.5
43hypercalcemia10.5
44retroperitoneal lymphoma10.5
45hepatitis a10.5
46cold agglutinin disease10.5
47diffuse large b-cell lymphoma of the central nervous system10.5
48hepatitis e10.4
49ataxia telangiectasia10.4
50common variable immunodeficiency10.4

Graphical network of the top 20 diseases related to Diffuse Large B-Cell Lymphoma:



Diseases related to diffuse large b-cell lymphoma

Clinical Features for Diffuse Large B-Cell Lymphoma

Drugs & Therapeutics for Diffuse Large B-Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Diffuse Large B-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Diffuse Large B-Cell Lymphoma

Search NIH Clinical Center for Diffuse Large B-Cell Lymphoma

Search CenterWatch for Diffuse Large B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diffuse Large B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Diffuse Large B-Cell Lymphoma

Anatomical Context for Diffuse Large B-Cell Lymphoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Diffuse Large B-Cell Lymphoma:

33
Spinal cord, Brain, Lung, Bone marrow, Whole blood, Smooth muscle, Colon, Breast, Testis, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Pituitary

Animal Models for Diffuse Large B-Cell Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Diffuse Large B-Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.0PRDM1, GAPDH, BCL6, IRF4, CASP3, PAX5
2MP:000538711.8PAX5, LMO2, CDKN2A, MYC, MALT1, PRDM1
3MP:000538411.7BCL6, CASP3, PAX5, CDKN2A, CD5, MYD88
4MP:000537811.6LMO2, CDKN2A, MYD88, MYC, PIM1, PRDM1
5MP:000301211.0CD5, CDKN2A, MYD88, MYC, PRDM1, PIM1

Publications for Diffuse Large B-Cell Lymphoma

Sources:
51PubMed
See all sources

Articles related to Diffuse Large B-Cell Lymphoma:

(show top 50)    (show all 316)
idTitleAuthorsYear
1
The clinical features, management and prognostic effects of pathological fractures in a multicenter series of 373 patients with diffuse large B-cell lymphoma of the bone. (24287938)
2014
2
Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma. (24299961)
2014
3
A new diagnostic algorithm for Burkitt and diffuse large B-cell lymphomas based on the expression of CSE1L and STAT3 and on MYC rearrangement predicts outcome. (22967991)
2013
4
Improvement in survival of diffuse large B-cell lymphoma in relation to age, gender, IPI and extranodal presentation: a population based Swedish Lymphoma Registry study. (24138330)
2013
5
Treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone is beneficial but toxic in very elderly patients with diffuse large B-cell lymphoma: a population-based cohort study on treatment, toxicity and outcome. (23734653)
2013
6
Primary breast diffuse large B cell lymphoma - report of 6 cases from South India with review of literature. (24426760)
2013
7
Amplified RPS6KB1 and CDC2 genes are potential biomarkers for aggressive HIV+/EBV+ diffuse large B-cell lymphomas. (23330000)
2013
8
Prognostic significance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B cell lymphoma patients. (24117687)
2013
9
Diffuse large B-cell lymphoma arising in a composite lymphoma with biclonality by flow cytometry and one monoclonal band by PCR. (24427364)
2013
10
ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type. (22938940)
2013
11
Development of IgG4-related disease 10 years after chemotherapy for diffuse large B cell lymphoma and longstanding bronchial asthma. (23666666)
2013
12
FDG PET/CT for the detection of bone marrow involvement in diffuse large B-cell lymphoma: systematic review and meta-analysis. (24281821)
2013
13
Interim PET/CT-based prognostic model for the treatment of diffuse large B cell lymphoma in the post-rituximab era. (23238895)
2013
14
Epstein-Barr virus-negative, CD5-positive diffuse large B-cell lymphoma developing after treatment with oral tacrolimus for mixed connective tissue disease : a case report and review of the literature. (23269082)
2012
15
Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death. (23065155)
2012
16
Leukocytoclastic vasculitis as early manifestation of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly. (22197862)
2012
17
Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: a clinic-based case-control study. (23010502)
2012
18
Epstein-Barr Virus-Associated Adrenal Smooth Muscle Tumors and Disseminated Diffuse Large B-Cell Lymphoma in a Child With Common Variable Immunodeficiency: A Case Report and Review of the Literature. (21454372)
2011
19
Bone involvement in two cases of thoracic primary cutaneous diffuse large B-cell lymphoma, leg type. (21700538)
2011
20
Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. (21670469)
2011
21
Composite diffuse large B-cell lymphoma and precursor B lymphoblastic lymphoma presenting as a double-hit lymphoma with MYC and BCL2 translocation. (21778297)
2011
22
Epstein-Barr virus-positive diffuse large B-cell lymphomas of the elderly. (21841405)
2011
23
Epstein-barr virus-positive diffuse large B-cell lymphoma of the elderly: what we know so far. (21212426)
2011
24
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. (20395518)
2010
25
Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases. (19935644)
2010
26
Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach. (19844983)
2010
27
Plasma TNF-alpha and IL-10 level-based prognostic model predicts outcome of patients with diffuse large B-Cell lymphoma in different risk groups defined by the International Prognostic Index. (20191326)
2010
28
T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. (20382409)
2010
29
Prognostic impact of protein kinase C beta II expression in R-CHOP-treated diffuse large B-cell lymphoma patients. (20190733)
2010
30
Novel lymphoid neoplasms--the borderland between diffuse large B-cell lymphoma and Burkitt's lymphoma. (19570750)
2009
31
Interaction between BCL2 and interleukin-10 gene polymorphisms alter outcomes of diffuse large B-cell lymphoma following rituximab plus CHOP chemotherapy. (19276283)
2009
32
Diffuse large B-cell lymphomas and burkitt lymphoma. (19577170)
2009
33
Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach. (19670467)
2009
34
BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. (19549844)
2009
35
Tyrosine kinase inhibition in diffuse large B-cell lymphoma: molecular basis for antitumor activity and drug resistance of dasatinib. (18596745)
2008
36
The expression of anamorsin in diffuse large B cell lymphoma: possible prognostic biomarker for low IPI patients. (18203020)
2008
37
Durable remission after the administration of rituximab for EBV-negative, diffuse large B-cell lymphoma following autologous peripheral blood stem cell transplantation for angioimmunoblastic T-cell lymphoma. (17325908)
2007
38
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. (17389337)
2007
39
Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma. (16400625)
2006
40
ESHAP + fixed dose G-CSF as autologous peripheral blood stem cell mobilization regimen in patients with relapsed or refractory diffuse large cell and Hodgkin's lymphoma: a single institution result of 127 patients. (16400345)
2006
41
Interferon (IFN)-beta induces apoptotic cell death in DHL-4 diffuse large B cell lymphoma cells through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (15922860)
2005
42
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
43
Homogeneous immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt's lymphoma and diffuse large B-cell lymphoma with MYC rearrangement. (15258997)
2004
44
Assessment of biological prognostic factors provides clinically relevant information in patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study. (15085385)
2004
45
Discordant bone marrow involvement in diffuse large B-cell lymphoma: comparative molecular analysis reveals a heterogeneous group of disorders. (12533691)
2003
46
Rearrangement of the BCL6 locus at 3q27 is an independent poor prognostic factor in nodal diffuse large B-cell lymphoma. (11972514)
2002
47
The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model. (11156256)
2000
48
Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene. (10653866)
2000
49
CD10 antigen expression correlates with the t(14;18)(q32;q21) major breakpoint region in diffuse large B-cell lymphoma. (10102615)
1999
50
Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma. (8142643)
1994

Genetic Variations for Diffuse Large B-Cell Lymphoma

Expression for genes affiliated with Diffuse Large B-Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diffuse Large B-Cell Lymphoma

Search GEO for disease gene expression data for Diffuse Large B-Cell Lymphoma.

Pathways for genes affiliated with Diffuse Large B-Cell Lymphoma

Sources:
30KEGG, 4Cell Signaling Technology, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Diffuse Large B-Cell Lymphoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1paraffin4511.5MALT1, MYC, CDKN2A, PAX5, BCL6, CD5
2cytidine45 11 2413.3PRDM1, MYC, BCL6, PAX5
3cytarabine45 50 1113.3CASP3, MYC, GAPDH, CDKN2A
4mg 13245 6012.3CASP3, GAPDH, CDKN2A, MYC
5agarose4511.3CASP3, CDKN2A, MYC, GAPDH
6imatinib45 50 1113.3BCL6, CASP3, MYC, GAPDH
7arsenite45 2412.2CDKN2A, CASP3, GAPDH, MYC
8n acetylcysteine4511.1GAPDH, MYC, CASP3, CDKN2A
9depsipeptide4511.1CDKN2A, CASP3, MYC
106-hydroxydopamine4511.1GAPDH, CASP3, MYC
11roscovitine4511.1CDKN2A, CASP3, MYC
12daunorubicin45 50 1113.1MYC, CDKN2A, CASP3
13oligonucleotide4511.0PAX5, GAPDH, MYC, MYD88, CDKN2A
14rapamycin4511.0PIM1, MYC, CASP3, GAPDH
15tachyplesin i4511.0MYC, CDKN2A
164-hydroxynonenal45 2412.0MYC, GAPDH, CASP3
17gemcitabine45 50 1113.0CASP3, MYC, GAPDH
18ly2940024510.9MYD88, MYC, GAPDH, CASP3
19trapoxin4510.9GAPDH, MYC
20vincristine45 50 1112.9MYC, BCL6, CDKN2A
21serine4510.9PIM1
22doxorubicin45 50 1112.6BCL6, CASP3, MYC, CDKN2A
23rasagiline45 1111.6GAPDH, CASP3

GO Terms for genes affiliated with Diffuse Large B-Cell Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.8BCL6, IRF4, GAPDH, PIM1, PRDM1, MALT1

Biological processes related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306610.7CASP3, PIM1, MALT1, MYC, MYD88
2negative regulation of B cell proliferationGO:03088910.7CDKN2A, PRDM1, CASP3
3negative regulation of cell-matrix adhesionGO:00195310.7CDKN2A, BCL6

Molecular functions related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.8CD5, BCL6, LMO2, CASP3, IRF4, GAPDH
2transcription factor bindingGO:00813410.8IRF4, PIM1, MYC, CDKN2A
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.4CDKN2A, CASP3

Products for genes affiliated with Diffuse Large B-Cell Lymphoma

  • Antibodies
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  • Lysates
  • Antibodies

Sources for Diffuse Large B-Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet