MCID: DFF005
MIFTS: 50

Diffuse Large B-Cell Lymphoma malady

Rare diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Diffuse Large B-Cell Lymphoma

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Diffuse Large B-Cell Lymphoma, Aliases & Descriptions:

Name: Diffuse Large B-Cell Lymphoma 30 9 11 60
Diffuse Large B-Cell Lymphoma, Not Otherwise Specified 60
 
Large B Cell Diffuse Lymphoma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:0050745
ICD1025 C83.3

Summaries for Diffuse Large B-Cell Lymphoma

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Disease Ontology:9 A b-cell lymphoma that is a cancer of b cells presenting as an aggressive tumour which can arise in virtually any part of the body.

MalaCards based summary: Diffuse Large B-Cell Lymphoma, also known as diffuse large b-cell lymphoma, not otherwise specified, is related to b-cell lymphomas and malt lymphoma. An important gene associated with Diffuse Large B-Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and TP53 network. The compounds tachyplesin i and trapoxin have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and t cells, and related mouse phenotypes are no phenotypic analysis and growth/size/body.

Related Diseases for Diffuse Large B-Cell Lymphoma

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Diseases related to Diffuse Large B-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas32.4PIM1, IGH, PAX5, MYC, IRF4, MALT1
2malt lymphoma31.8IGH, IRF4, MALT1, BCL6
3burkitt lymphoma31.8BCL6, PAX5
4macroglobulinemia31.8PAX5
5follicular lymphoma31.8IGH, PAX5, MYC, IRF4, BCL6
6hodgkin lymphoma31.7IGH, PAX5, IRF4, BCL6
7peripheral t-cell lymphoma31.4BCL6, PAX5
8central nervous system lymphoma31.4BCL6
9chronic lymphocytic leukemia31.4CASP3, BCL6, PAX5, IGH
10primary effusion lymphoma31.3BCL6, MYC
11lymphoblastic lymphoma31.1BCL6, PAX5
12gastric lymphoma31.0IGH, MALT1, BCL6
13waldenstrom macroglobulinemia30.9IGH, PAX5, IRF4
14ewing sarcoma30.9MYC, CASP3
15leukemia30.8PIM1, IGH, PAX5, MYC, IRF4, BCL6
16reticulosarcoma30.8CASP3, BCL6, PAX5, IGH
17t-cell leukemia30.8IGH, MYC, IRF4, CASP3
18myeloma30.5IGH, PAX5, MYC, IRF4, BCL6, CASP3
19primary cutaneous diffuse large b-cell lymphoma, leg type11.1
20epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly11.0
21mediastinitis10.8
22hepatitis10.8
23diffuse large b-cell lymphoma of the central nervous system10.8
24mantle cell lymphoma10.8
25endotheliitis10.8
26arthritis10.7
27angioimmunoblastic t-cell lymphoma10.7
28rheumatoid arthritis10.7
29hepatitis c10.7
30composite lymphoma10.7
31lymphoplasmacytic lymphoma10.7
32hepatitis c virus10.6
33hematopoietic stem cell transplantation10.6
34hemolytic anemia10.6
35marginal zone b-cell lymphoma10.6
36neutropenia10.6
37plasmablastic lymphoma10.6
38primary mediastinal large b-cell lymphoma10.6
39anaplastic large cell lymphoma10.6
40autoimmune hemolytic anemia10.6
41thyroiditis10.6
42hypoxia10.6
43diffuse large b-cell lymphoma with chronic inflammation10.6
44nodular lymphocyte predominant hodgkin lymphoma10.6
45intravascular large b-cell lymphoma10.6
46richter's syndrome10.5
47pure red-cell aplasia10.5
48hypercalcemia10.5
49adenocarcinoma10.5
50lactic acidosis10.5

Graphical network of the top 20 diseases related to Diffuse Large B-Cell Lymphoma:



Diseases related to diffuse large b-cell lymphoma

Symptoms for Diffuse Large B-Cell Lymphoma

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Drugs & Therapeutics for Diffuse Large B-Cell Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Diffuse Large B-Cell Lymphoma

Search NIH Clinical Center for Diffuse Large B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Diffuse Large B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Diffuse Large B-Cell Lymphoma

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Anatomical Context for Diffuse Large B-Cell Lymphoma

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MalaCards organs/tissues related to Diffuse Large B-Cell Lymphoma:

31
B cells, Bone, T cells, Bone marrow, Breast, Endothelial, Monocytes, Spleen, Lung, Thyroid, Testis, Colon, Liver, Skin, Lymph node, Spinal cord, Smooth muscle, Prostate, Myeloid, B lymphoblasts, Pituitary, Neutrophil, Thymus, Brain, Heart, Small intestine, Kidney, Ovary, Uterus, Tonsil, Nk cells

Animal Models for Diffuse Large B-Cell Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Diffuse Large B-Cell Lymphoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6PIM1, MYC, MYD88, BCL6, CASP3, CDKN2A
2MP:00053788.3PAX5, MYC, MYD88, BCL6, CASP3, GAPDH
3MP:00053977.9CDKN2A, PIM1, PAX5, MYC, MYD88, IRF4
4MP:00053877.7PIM1, PAX5, MYC, MYD88, IRF4, MALT1

Publications for Diffuse Large B-Cell Lymphoma

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Articles related to Diffuse Large B-Cell Lymphoma:

(show top 50)    (show all 1422)
idTitleAuthorsYear
1
Upregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity. (25864113)
2015
2
Epstein-Barr virus-positive diffuse large B-cell lymphoma in children: a disease reminiscent of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly. (25704629)
2015
3
Independent growth of diffuse large B cell lymphoma and angioimmunoblastic T cell lymphoma originating from composite lymphoma. (24488225)
2014
4
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome. (23859481)
2013
5
Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP. (24220563)
2013
6
Paradoxical Regulation of Hypoxia Inducible Factor-1I+ (HIF-1I+) by Histone Deacetylase Inhibitor in Diffuse Large B-Cell Lymphoma. (24312289)
2013
7
An international confirmatory study of the prognostic value of early PET/CT in diffuse large B-cell lymphoma: comparison between Deauville criteria and I9SUVmax. (23649463)
2013
8
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
9
Massive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas. (24223701)
2013
10
Expression and significance of leptin receptor, p-STAT3 and p-AKT in diffuse large B-cell lymphoma. (24054064)
2013
11
Combination of YM155, a survivin suppressant with a STAT3 inhibitor: a new strategy to treat diffuse large B-cell lymphoma. (23746965)
2013
12
The derived neutrophil to lymphocyte ratio is an independent prognostic factor in patients with diffuse large B-cell lymphoma. (24357794)
2013
13
Limited role for surveillance PET-CT scanning in patients with diffuse large B-cell lymphoma in complete metabolic remission following primary therapy. (23807169)
2013
14
Case report and review of primary bone diffuse large B-cell lymphoma involving the calcaneus. (23628193)
2013
15
Cell cycle regulation score predicts relapse-free survival in non-germinal centre diffuse large B-cell lymphoma patients treated by means of immunochemotherapy. (23560495)
2013
16
Lenalidomide in diffuse large B-cell lymphomas. (22792112)
2012
17
Treatment of patients with refractory diffuse large B-cell lymphoma or mantle cell lymphoma with alemtuzumab, alone or in combination with cytotoxic chemotherapy. (21067447)
2011
18
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
19
Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. (21173233)
2011
20
Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas. (21638516)
2011
21
Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency. (21094993)
2011
22
Genotypic and phenotypic differences between nodal and extranodal diffuse large B-Cell lymphomas. (21832150)
2011
23
Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. (20651244)
2010
24
A rare reason of foot drop caused by primary diffuse large b-cell lymphoma of the sciatic nerve: case report. (19415174)
2010
25
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. (20395518)
2010
26
Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases. (19935644)
2010
27
Caspase 3a: new prognostic marker for diffuse large B-cell lymphoma in the rituximab era. (20919853)
2010
28
Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP. (19629486)
2010
29
Blimp-1 protein and Hans classification on prognosis of diffuse large B-cell lymphoma and their interrelation. (20800019)
2010
30
Nuclear expression of YB-1 in diffuse large B-cell lymphoma: correlation with disease activity and patient outcome. (19500133)
2009
31
BCL2 expression in de novo diffuse large B-cell lymphoma partly reflects normal differences in age distribution. (19508293)
2009
32
Identification of biological markers of sensitivity to high-clinical-risk-adapted therapy for patients with diffuse large B-cell lymphoma. (19373655)
2009
33
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. (17916749)
2008
34
Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. (18539616)
2008
35
Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas. (18312353)
2008
36
Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience. (18925695)
2008
37
Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin. (17516749)
2007
38
ERCC1 Expression in Diffuse Large B-Cell Lymphoma Patients Treated with a Cisplatin-Based Regimen : A Brief Communication. (19190690)
2007
39
Distribution patterns of dendritic cells and T cells in diffuse large B-cell lymphomas correlate with prognoses. (18006767)
2007
40
Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. (16424392)
2006
41
CD5-positive diffuse large B-cell lymphoma with an unusual phenotype: Cytoplasmic CD20 (+), surface CD20 (-). (16923582)
2006
42
Diffuse large B-cell lymphoma with expression of anaplastic lymphoma kinase protein: clinicopathologic and immunohistochemical study of 5 cases]. (17134546)
2006
43
Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma. (14979479)
2004
44
A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. (15162151)
2004
45
Alpha-2,6-sialylation of L-PHA reactive oligosaccharides and expression of N-acetylglucosaminyltransferase V in human diffuse large B cell lymphoma. (14534692)
2003
46
T(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients. (14502259)
2003
47
Plasma exchange and continuous hemodiafiltration as an initial treatment for diffuse large B-cell lymphoma-associated hemophagocytic syndrome]. (11868363)
2002
48
Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. (12407182)
2002
49
A reassessment of primary thyroid lymphoma: high-grade MALT-type lymphoma as a distinct subtype of diffuse large B-cell lymphoma. (10931213)
2000
50
De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct. (7541611)
1995

Variations for Diffuse Large B-Cell Lymphoma

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Expression for genes affiliated with Diffuse Large B-Cell Lymphoma

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Search GEO for disease gene expression data for Diffuse Large B-Cell Lymphoma.

Pathways for genes affiliated with Diffuse Large B-Cell Lymphoma

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Pathways related to Diffuse Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MYC, CDKN2A
2
Show member pathways
10.1MYC, CDKN2A
39.9MYD88, IRF4, MALT1
49.8CASP3, MALT1, MYD88
5
Show member pathways
DNA damage response36
9.8CDKN2A, CASP3, MYC
6
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.7MYC, BCL6, CDKN2A
79.7BCL6, MYC, PAX5
89.7MYC, PAX5, PIM1
9
Show member pathways
Signal transduction PTEN pathway58
9.7CASP3, MYC, PIM1
10
Show member pathways
Type III interferon signaling36
9.6PIM1, MYC, IL9R
119.5PIM1, MYC, GAPDH
129.5PIM1, MYC, MALT1, CASP3
13
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.4CDKN2A, CASP3, IRF4, MYD88, MYC
149.1PIM1, PAX5, MYD88, MALT1, BCL6
159.1MIR223, MIR24-1, MIR17, MYC
168.5PIM1, MYC, MIR17, MIR223, CASP3, CDKN2A

Compounds for genes affiliated with Diffuse Large B-Cell Lymphoma

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Compounds related to Diffuse Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1tachyplesin i4310.4CDKN2A, MYC
2trapoxin4310.2GAPDH, MYC
3depsipeptide4310.2CDKN2A, CASP3, MYC
4roscovitine4310.2CDKN2A, CASP3, MYC
5phenethyl isothiocyanate2 4311.2CASP3, MYC
6daunorubicin43 49 1212.1CDKN2A, CASP3, MYC
7cytidine43 24 1212.1BCL6, MYC, PAX5
8hmba4310.1CDKN2A, MYC
9vitamin e succinate4310.0CASP3, MYC
10adriamycin4310.0CDKN2A, CASP3, MYC
11rasagiline43 1211.0GAPDH, CASP3
12camptothecin43 59 1212.0MYC, CASP3, CDKN2A
136-hydroxydopamine4310.0MYC, CASP3, GAPDH
14vincristine43 49 1212.0MYC, BCL6, CDKN2A
15docetaxel43 49 59 1213.0CDKN2A, CASP3, MYC
164-hydroxynonenal43 2410.9MYC, CASP3, GAPDH
17gemcitabine43 49 1211.9MYC, CASP3, GAPDH
18ethidium bromide439.9IGH, CASP3, GAPDH
19cytarabine43 49 1211.8MYC, CASP3, GAPDH, CDKN2A
20mg 13243 5910.8MYC, CASP3, GAPDH, CDKN2A
21arsenite43 2410.8MYC, CASP3, GAPDH, CDKN2A
22doxorubicin43 49 1211.8MYC, BCL6, CASP3, CDKN2A
23[alcl]439.8MYC, PAX5
24n acetylcysteine439.7MYC, CASP3, GAPDH, CDKN2A
25ly294002439.7GAPDH, CASP3, MYD88, MYC
26paraffin439.7CDKN2A, BCL6, MALT1, MYC, PAX5
27imatinib43 49 1211.7GAPDH, CASP3, BCL6, MYC
28actinomycin d439.7CDKN2A, GAPDH, CASP3, MYC
29rapamycin439.6GAPDH, CASP3, MYC, PIM1
30cisplatin43 49 59 1212.5MYC, CASP3, GAPDH, CDKN2A
31agarose439.5CDKN2A, GAPDH, CASP3, MYC, IGH
32cycloheximide439.4MYC, BCL6, CASP3, GAPDH, CDKN2A
33oligonucleotide439.3IGH, PAX5, MYC, MYD88, GAPDH, CDKN2A
34retinoic acid43 2410.0MYC, BCL6, CASP3, GAPDH, CDKN2A
35serine438.7PIM1, PAX5, MYC, MYD88, BCL6, CASP3

GO Terms for genes affiliated with Diffuse Large B-Cell Lymphoma

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Cellular components related to Diffuse Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056347.8CDKN2A, PASD1, PAX5, MYC, IRF4, MALT1

Biological processes related to Diffuse Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:00019539.9CDKN2A, BCL6
2negative regulation of B cell proliferationGO:00308899.9CASP3, CDKN2A
3cellular response to DNA damage stimulusGO:00069749.7CASP3, BCL6, MYC
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.7CDKN2A, CASP3
5negative regulation of apoptotic processGO:00430669.3CASP3, MALT1, MYD88, MYC, PIM1

Molecular functions related to Diffuse Large B-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:000486110.0CDKN2A, CASP3
2transcription factor bindingGO:00081349.2CDKN2A, IRF4, MYC, PIM1

Products for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources for Diffuse Large B-Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet