DLBCL
MCID: DFF005
MIFTS: 60

Diffuse Large B-Cell Lymphoma (DLBCL) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Diffuse Large B-Cell Lymphoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A b-cell lymphocytic neoplasm that is a cancer of b cells presenting as an aggressive tumour which can arise in virtually any part of the body.

MalaCards: Diffuse Large B-Cell Lymphoma, also known as large b cell diffuse lymphoma, is related to b-cell lymphomas and follicular lymphoma. An important gene associated with Diffuse Large B-Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are TP53 network and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds tachyplesin i and trapoxin have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are no phenotypic analysis and growth/size/body.

Aliases & Classifications for Diffuse Large B-Cell Lymphoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 31LifeMap Discovery™, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
diffuse large b-cell lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

diffuse large b-cell lymphoma 8 10 49 31 62
large b cell diffuse lymphoma 43
dlbcl 49


External Ids:

Disease Ontology8 DOID:0050745
MESH via Orphanet36 D016403
ICD10 via Orphanet26 C83.3
SNOMED-CT via Orphanet59 109969005, 46732000
UMLS via Orphanet63 C0079744

Related Diseases for Diffuse Large B-Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases in the Diffuse Large B-Cell Lymphoma family:

Lymphoma, Diffuse Large Cell

Diseases related to Diffuse Large B-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas32.7PIM1, CASP3, BCL6, MALT1, IRF4, MYC
2follicular lymphoma31.6MYC, IRF4, PAX5, IGH, BCL6
3malt lymphoma31.5IRF4, MALT1, IGH, BCL6
4peripheral t-cell lymphoma31.3BCL6, PAX5
5macroglobulinemia31.2PAX5
6burkitt's lymphoma31.2BCL6, PAX5
7leukemia31.2PIM1, GAPDH, CASP3, BCL6, IRF4, MYC
8chronic lymphocytic leukemia31.1IGH, PAX5, BCL6, CASP3
9hodgkin's lymphoma31.0PAX5, BCL6, IRF4, IGH
10central nervous system lymphoma30.8BCL6
11b-cell chronic lymphocytic leukemia30.8PAX5, IGH
12lymphoblastic lymphoma30.8PAX5, BCL6
13gastric lymphoma30.6BCL6, MALT1, IGH
14lymphoma, diffuse large cell30.5PAX5, BCL6, MYC
15reticulosarcoma30.5PAX5, CASP3, BCL6, IGH
16t-cell leukemia30.5CASP3, IRF4, MYC, IGH
17myeloma30.4PAX5, CASP3, BCL6, IRF4, IGH, MYC
18primary cutaneous diffuse large b-cell lymphoma, leg type10.9
19epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly10.9
20mediastinitis10.8
21mantle cell lymphoma10.8
22diffuse large b-cell lymphoma of the central nervous system10.8
23hepatitis10.7
24endotheliitis10.7
25lymphoplasmacytic lymphoma10.7
26primary mediastinal large b-cell lymphoma10.7
27arthritis10.6
28hemolytic anemia10.6
29marginal zone b-cell lymphoma10.6
30rheumatoid arthritis10.6
31angioimmunoblastic t-cell lymphoma10.6
32hematopoietic stem cell transplantation10.6
33autoimmune hemolytic anemia10.6
34anaplastic large cell lymphoma10.6
35neutropenia10.6
36plasmablastic lymphoma10.6
37hypoxia10.6
38diffuse large b-cell lymphoma with chronic inflammation10.6
39nodular lymphocyte predominant hodgkin lymphoma10.6
40intravascular large b-cell lymphoma10.6
41hepatitis c10.5
42richter's syndrome10.5
43pure red-cell aplasia10.5
44hypercalcemia10.5
45composite lymphoma10.5
46ophthalmoplegia10.5
47sarcoma10.5
48thyroiditis10.5
49cold agglutinin disease10.5
50t-cell/histiocyte rich large b cell lymphoma10.5

Graphical network of the top 20 diseases related to Diffuse Large B-Cell Lymphoma:



Diseases related to diffuse large b-cell lymphoma

Symptoms for Diffuse Large B-Cell Lymphoma

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Drugs & Therapeutics for Diffuse Large B-Cell Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
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Drug clinical trials:

Search ClinicalTrials for Diffuse Large B-Cell Lymphoma

Search NIH Clinical Center for Diffuse Large B-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Diffuse Large B-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Diffuse Large B-Cell Lymphoma

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Anatomical Context for Diffuse Large B-Cell Lymphoma

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33MalaCards
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MalaCards organs/tissues related to Diffuse Large B-Cell Lymphoma:

33
B cells, T cells, Bone, Bone marrow, Endothelial, Breast, Monocytes, Spleen, Lung, Testis, Skin, Thyroid, Colon, Liver, Myeloid, Prostate, B lymphoblasts, Smooth muscle, Lymph node, Spinal cord, Thymus, Brain, Nk cells, Tonsil, Heart, Uterus, Small intestine, Kidney, Pituitary

Animal Models for Diffuse Large B-Cell Lymphoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Diffuse Large B-Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6PIM1, MYC, MYD88, BCL6, CASP3, CDKN2A
2MP:00053788.3PAX5, MYC, MYD88, BCL6, CASP3, GAPDH
3MP:00053977.9CDKN2A, PIM1, PAX5, MYC, MYD88, IRF4
4MP:00053877.7PIM1, PAX5, MYC, MYD88, IRF4, MALT1

Publications for Diffuse Large B-Cell Lymphoma

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Sources:
52PubMed
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Articles related to Diffuse Large B-Cell Lymphoma:

(show top 50)    (show all 1319)
idTitleAuthorsYear
1
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome. (23859481)
2013
2
Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP. (24220563)
2013
3
Paradoxical Regulation of Hypoxia Inducible Factor-1I+ (HIF-1I+) by Histone Deacetylase Inhibitor in Diffuse Large B-Cell Lymphoma. (24312289)
2013
4
An international confirmatory study of the prognostic value of early PET/CT in diffuse large B-cell lymphoma: comparison between Deauville criteria and I9SUVmax. (23649463)
2013
5
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
6
Massive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas. (24223701)
2013
7
Expression and significance of leptin receptor, p-STAT3 and p-AKT in diffuse large B-cell lymphoma. (24054064)
2013
8
Combination of YM155, a survivin suppressant with a STAT3 inhibitor: a new strategy to treat diffuse large B-cell lymphoma. (23746965)
2013
9
The derived neutrophil to lymphocyte ratio is an independent prognostic factor in patients with diffuse large B-cell lymphoma. (24357794)
2013
10
Limited role for surveillance PET-CT scanning in patients with diffuse large B-cell lymphoma in complete metabolic remission following primary therapy. (23807169)
2013
11
Cell cycle regulation score predicts relapse-free survival in non-germinal centre diffuse large B-cell lymphoma patients treated by means of immunochemotherapy. (23560495)
2013
12
Composite lymphoma after chemotherapy with regressed diffuse large B-cell lymphoma and transformed cytotoxic T-cell lymphoma. (23009219)
2013
13
CD56 positive diffuse large B-cell lymphoma: a case report and literature review. (24294395)
2013
14
Lenalidomide in diffuse large B-cell lymphomas. (22792112)
2012
15
Expression of microRNA-223 and its clinicopathologic correlation in diffuse large B-cell lymphoma]. (22932402)
2012
16
Treatment of patients with refractory diffuse large B-cell lymphoma or mantle cell lymphoma with alemtuzumab, alone or in combination with cytotoxic chemotherapy. (21067447)
2011
17
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
18
Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. (21173233)
2011
19
Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas. (21638516)
2011
20
Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency. (21094993)
2011
21
Genotypic and phenotypic differences between nodal and extranodal diffuse large B-Cell lymphomas. (21832150)
2011
22
Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. (20651244)
2010
23
A rare reason of foot drop caused by primary diffuse large b-cell lymphoma of the sciatic nerve: case report. (19415174)
2010
24
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. (20395518)
2010
25
Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases. (19935644)
2010
26
Caspase 3a: new prognostic marker for diffuse large B-cell lymphoma in the rituximab era. (20919853)
2010
27
Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP. (19629486)
2010
28
Blimp-1 protein and Hans classification on prognosis of diffuse large B-cell lymphoma and their interrelation. (20800019)
2010
29
Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. (20200556)
2010
30
Nuclear expression of YB-1 in diffuse large B-cell lymphoma: correlation with disease activity and patient outcome. (19500133)
2009
31
BCL2 expression in de novo diffuse large B-cell lymphoma partly reflects normal differences in age distribution. (19508293)
2009
32
Identification of biological markers of sensitivity to high-clinical-risk-adapted therapy for patients with diffuse large B-cell lymphoma. (19373655)
2009
33
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. (17916749)
2008
34
Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. (18539616)
2008
35
Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas. (18312353)
2008
36
Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphoma: single center experience. (18925695)
2008
37
Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin. (17516749)
2007
38
ERCC1 Expression in Diffuse Large B-Cell Lymphoma Patients Treated with a Cisplatin-Based Regimen : A Brief Communication. (19190690)
2007
39
Distribution patterns of dendritic cells and T cells in diffuse large B-cell lymphomas correlate with prognoses. (18006767)
2007
40
Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. (16424392)
2006
41
CD5-positive diffuse large B-cell lymphoma with an unusual phenotype: Cytoplasmic CD20 (+), surface CD20 (-). (16923582)
2006
42
Diffuse large B-cell lymphoma with expression of anaplastic lymphoma kinase protein: clinicopathologic and immunohistochemical study of 5 cases]. (17134546)
2006
43
Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma. (14979479)
2004
44
A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. (15162151)
2004
45
Alpha-2,6-sialylation of L-PHA reactive oligosaccharides and expression of N-acetylglucosaminyltransferase V in human diffuse large B cell lymphoma. (14534692)
2003
46
T(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients. (14502259)
2003
47
Plasma exchange and continuous hemodiafiltration as an initial treatment for diffuse large B-cell lymphoma-associated hemophagocytic syndrome]. (11868363)
2002
48
Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. (12407182)
2002
49
A reassessment of primary thyroid lymphoma: high-grade MALT-type lymphoma as a distinct subtype of diffuse large B-cell lymphoma. (10931213)
2000
50
De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct. (7541611)
1995

Variations for Diffuse Large B-Cell Lymphoma

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Expression for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diffuse Large B-Cell Lymphoma

Search GEO for disease gene expression data for Diffuse Large B-Cell Lymphoma.

Pathways for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 5Cell Signaling Technology, 30KEGG, 60Thomson Reuters
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Pathways related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1CDKN2A, MYC
210.1CDKN2A, MYC
39.9MALT1, IRF4, MYD88
49.8MALT1, CASP3, MYD88
5
Show member pathways
DNA damage response38
9.8MYC, CASP3, CDKN2A
6
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.7CDKN2A, MYC, BCL6
79.7PAX5, MYC, BCL6
89.7PAX5, MYC, PIM1
9
Show member pathways
Signal transduction PTEN pathway60
9.7MYC, PIM1, CASP3
10
Show member pathways
Type III interferon signaling38
9.6MYC, IL9R, PIM1
119.5MYC, PIM1, GAPDH
129.5MYC, PIM1, MALT1, CASP3
13
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.4MYD88, MYC, IRF4, CASP3, CDKN2A
149.1PIM1, BCL6, MALT1, MYD88, PAX5
159.1MIR17, MIR24-1, MYC, MIR223
168.5MIR17, CASP3, CDKN2A, MIR223, PIM1, MYC

Compounds for genes affiliated with Diffuse Large B-Cell Lymphoma

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45Novoseek, 3BitterDB, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience
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Compounds related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1tachyplesin i4510.4CDKN2A, MYC
2trapoxin4510.2GAPDH, MYC
3depsipeptide4510.2CDKN2A, CASP3, MYC
4roscovitine4510.2CDKN2A, CASP3, MYC
5phenethyl isothiocyanate3 4511.2CASP3, MYC
6daunorubicin45 51 1112.1CDKN2A, CASP3, MYC
7cytidine45 24 1112.1BCL6, MYC, PAX5
8hmba4510.1CDKN2A, MYC
9vitamin e succinate4510.0CASP3, MYC
10adriamycin4510.0CDKN2A, CASP3, MYC
11rasagiline45 1111.0GAPDH, CASP3
12camptothecin45 61 1112.0MYC, CASP3, CDKN2A
136-hydroxydopamine4510.0MYC, CASP3, GAPDH
14vincristine45 51 1112.0MYC, BCL6, CDKN2A
15docetaxel45 51 61 1113.0CDKN2A, CASP3, MYC
164-hydroxynonenal45 2410.9MYC, CASP3, GAPDH
17gemcitabine45 51 1111.9MYC, CASP3, GAPDH
18ethidium bromide459.9IGH, CASP3, GAPDH
19cytarabine45 51 1111.8MYC, CASP3, GAPDH, CDKN2A
20mg 13245 6110.8MYC, CASP3, GAPDH, CDKN2A
21arsenite45 2410.8MYC, CASP3, GAPDH, CDKN2A
22doxorubicin45 51 1111.8MYC, BCL6, CASP3, CDKN2A
23[alcl]459.8MYC, PAX5
24n acetylcysteine459.7MYC, CASP3, GAPDH, CDKN2A
25ly294002459.7GAPDH, CASP3, MYD88, MYC
26paraffin459.7CDKN2A, BCL6, MALT1, MYC, PAX5
27imatinib45 51 1111.7GAPDH, CASP3, BCL6, MYC
28actinomycin d459.7CDKN2A, GAPDH, CASP3, MYC
29rapamycin459.6GAPDH, CASP3, MYC, PIM1
30cisplatin45 51 61 1112.5MYC, CASP3, GAPDH, CDKN2A
31agarose459.5CDKN2A, GAPDH, CASP3, MYC, IGH
32cycloheximide459.4MYC, BCL6, CASP3, GAPDH, CDKN2A
33oligonucleotide459.3IGH, PAX5, MYC, MYD88, GAPDH, CDKN2A
34retinoic acid45 2410.0MYC, BCL6, CASP3, GAPDH, CDKN2A
35serine458.7PIM1, PAX5, MYC, MYD88, BCL6, CASP3

GO Terms for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources:
16Gene Ontology
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Cellular components related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.8CDKN2A, PASD1, PAX5, MYC, IRF4, MALT1

Biological processes related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.9CDKN2A, BCL6
2negative regulation of B cell proliferationGO:0308899.9CASP3, CDKN2A
3cellular response to DNA damage stimulusGO:0069749.7CASP3, BCL6, MYC
4negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.7CDKN2A, CASP3
5negative regulation of apoptotic processGO:0430669.3CASP3, MALT1, MYD88, MYC, PIM1

Molecular functions related to Diffuse Large B-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.0CDKN2A, CASP3
2transcription factor bindingGO:0081349.2CDKN2A, IRF4, MYC, PIM1

Products for genes affiliated with Diffuse Large B-Cell Lymphoma

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Sources for Diffuse Large B-Cell Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet