MCID: DFF021
MIFTS: 38

Diffuse Mesangial Sclerosis malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Diffuse Mesangial Sclerosis

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Aliases & Descriptions for Diffuse Mesangial Sclerosis:

Name: Diffuse Mesangial Sclerosis 45 65
Diffuse Mesangial Sclerosis Syndromes 22 24
Isolated Diffuse Mesangial Sclerosis 45 22
Familial Mesangial Sclerosis 45 65
Mesangial Sclerosis, Diffuse 45 47
 
Nephrotic Syndrome, Early Onset with Diffuse Mesangial Sclerosis 45
Diffuse Isolated Mesangial Sclerosis 45
Idms 22
Dms 45

Classifications:



External Ids:

UMLS65 C0268747, C3489732

Summaries for Diffuse Mesangial Sclerosis

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MalaCards based summary: Diffuse Mesangial Sclerosis, also known as diffuse mesangial sclerosis syndromes, is related to nephrotic syndrome, type 4 and pierson syndrome. An important gene associated with Diffuse Mesangial Sclerosis is WT1 (Wilms Tumor 1), and among its related pathways are G-protein signaling_RhoB regulation pathway and Nephrin/Neph1 signaling in the kidney podocyte. Affiliated tissues include bone, brain and endothelial, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Related Diseases for Diffuse Mesangial Sclerosis

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Diseases related to Diffuse Mesangial Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome, type 432.9NPHS1, PAX2, WT1
2pierson syndrome31.4LAMB1, LAMB2
3sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis12.6
4familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis12.6
5dermatomyositis11.6
6myotonic dystrophy 111.6
7epidermolysis bullosa simplex, dowling-meara type11.6
8diaphyseal medullary stenosis with malignant fibrous histiocytoma11.3
9childhood type dermatomyositis11.3
10neonatal dermatomyositis11.3
11rheumatoid arthritis10.8
12nephrotic syndrome, type 310.8
13denys-drash syndrome10.7
14osteoarthritis10.7
15nephrotic syndrome, type 810.6
16hepatitis c virus10.4
17ductal carcinoma in situ10.4
18maturity-onset diabetes of the young10.4
19diabetes insipidus10.4
20lymphoma10.3
21nephrogenic adenofibroma10.2PAX2, WT1
22h. pylori infection10.2
23duchenne muscular dystrophy10.2
24influenza10.2
25gastroesophageal junction adenocarcinoma10.2PAX2, WT1
26liver sarcoma10.2PAX2, WT1
27familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.2ARHGDIA, PLCE1, WT1
28breast pericanalicular fibroadenoma10.2PAX2, WT1
29schizophrenia10.0
30bronchiolitis obliterans10.0
31cataract10.0
32dilated cardiomyopathy10.0
33muscle disorders10.0
34myasthenia gravis10.0
35pulmonary emphysema10.0
36atrial fibrillation10.0
37microphthalmia10.0
38gastrojejunal ulcer10.0
39hemiplegia10.0
40acute salpingitis10.0
41chlamydia10.0
42diabetic cataract10.0
43dyspepsia10.0
44ovarian cancer10.0
45pyelitis10.0
46bronchiolitis10.0
47cockayne syndrome10.0
48astrocytoma10.0
49tuberculosis10.0
50pilomyxoid astrocytoma10.0

Graphical network of the top 20 diseases related to Diffuse Mesangial Sclerosis:



Diseases related to diffuse mesangial sclerosis

Symptoms for Diffuse Mesangial Sclerosis

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Drugs & Therapeutics for Diffuse Mesangial Sclerosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Diffuse Mesangial Sclerosis

Genetic Tests for Diffuse Mesangial Sclerosis

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Genetic tests related to Diffuse Mesangial Sclerosis:

id Genetic test Affiliating Genes
1 Diffuse Mesangial Sclerosis Syndromes (dms)22 WT1
2 Isolated Diffuse Mesangial Sclerosis22 WT1

Anatomical Context for Diffuse Mesangial Sclerosis

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MalaCards organs/tissues related to Diffuse Mesangial Sclerosis:

33
Bone, Brain, Endothelial, Neutrophil

Animal Models for Diffuse Mesangial Sclerosis or affiliated genes

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MGI Mouse Phenotypes related to Diffuse Mesangial Sclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.9ARHGDIA, LAMB2, LAMC1, NPHS1, NPHS2, PAX2
2MP:00053857.9ARHGDIA, LAMC1, NPHS2, PAX2, PLCE1, WT1
3MP:00107687.1ARHGDIA, LAMB1, LAMB2, LAMC1, NPHS1, NPHS2

Publications for Diffuse Mesangial Sclerosis

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Articles related to Diffuse Mesangial Sclerosis:

(show all 37)
idTitleAuthorsYear
1
Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction. (25692331)
2015
2
Activation of IGF-1 and insulin signaling pathways ameliorate mitochondrial function and energy metabolism in Huntington's Disease human lymphoblasts. (24841383)
2015
3
Clinical differences in Clostridium difficile infection based on age: A multicenter study. (24106984)
2014
4
Oral manifestation of autosomal recessive congenital ichthyosis in a 2-year-old patient. (24995134)
2014
5
High Calorie Intake Is Associated With Worsening Insulin Resistance and I^-Cell Function in Hispanic Women After Gestational Diabetes Mellitus. (25404660)
2014
6
Decreased mortality associated with statin treatment in patients with acute myocardial infarction and lymphotoxin-alpha C804A polymorphism. (23398946)
2013
7
Optimal treatment for intracranial germinoma: can we lower radiation dose without chemotherapy? (19864081)
2010
8
Ruptured ectopic pregnancy. (20548215)
2010
9
The role of phospholipase D in osteoblast response to titanium surface microstructure. (19705469)
2010
10
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. (18836486)
2009
11
Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort. (18413218)
2008
12
ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines. (18194454)
2008
13
Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis. (18802018)
2008
14
Refractive hypotension in a patient with disulfiram-ethanol reaction. (17220694)
2007
15
The C2A-C2B linker defines the high affinity Ca(2+) binding mode of rabphilin-3A. (17166855)
2007
16
S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase. (17550782)
2007
17
Protein phosphatases types 2Calpha and 2Cbeta in apoptosis. (17073821)
2006
18
Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China. (15643524)
2005
19
Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor. (16009468)
2005
20
Cutaneous paraneoplastic syndromes: uncommon presentations. (16325068)
2005
21
Differential effects of transforming growth factor-beta1, a fibrogenic factor, on macrophage-like cells (HS-P) and myofibroblastic cells (MT-9) in vitro. (11560254)
2001
22
A novel mis-sense mutation (G1381A) in the G6PD gene identified in a Chinese man. (11780463)
2001
23
Primary spinal epidural extraosseous Ewing's sarcoma: report of five cases and literature review. (11531770)
2001
24
Unclassified or undifferentiated connective tissue disease. (10882218)
2000
25
The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense. (9665269)
1998
26
Lose salt and gain a friend! A tribute to Gerhard Giebisch. (9261995)
1997
27
Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation. (8798782)
1996
28
A critical role for nitric oxide in intestinal barrier function and dysfunction. (8779963)
1996
29
Reflex sympathetic dystrophy in children. Dystrophic changes are less likely. (8520356)
1995
30
Cephalic tetanus presenting with incomplete Bell's palsy. (8056552)
1994
31
Effect of modification of carbohydrate component on properties of glucoamylase. (8420800)
1993
32
Accessory navicular bone. (8370227)
1993
33
Aneurysms of the extracranial internal carotid artery due to fibromuscular dysplasia: results of surgical management. (1610650)
1992
34
Porphyromonas gingivalis fimbriae induce expression of the neutrophil chemotactic factor KC gene of mouse peritoneal macrophages: role of protein kinase C. (1372296)
1992
35
Establishment of clonal cell lines, with or without cartilage phenotypes, from a hamster mesenchymal chondrosarcoma. (1667204)
1991
36
Ovine brain areas sensitive to naloxone-induced stimulation of luteinizing hormone release. (2175851)
1990
37
A distinct variant of intermediate maple syrup urine disease. (3978850)
1985

Variations for Diffuse Mesangial Sclerosis

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Expression for genes affiliated with Diffuse Mesangial Sclerosis

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Search GEO for disease gene expression data for Diffuse Mesangial Sclerosis.

Pathways for genes affiliated with Diffuse Mesangial Sclerosis

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GO Terms for genes affiliated with Diffuse Mesangial Sclerosis

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Cellular components related to Diffuse Mesangial Sclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1laminin-1 complexGO:00056069.7LAMB1, LAMC1
2basement membraneGO:00056049.0LAMB1, LAMB2, LAMC1

Biological processes related to Diffuse Mesangial Sclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular visceral epithelial cell developmentGO:007224910.2LAMB2, NPHS2
2glomerulus developmentGO:003283510.1PLCE1, WT1
3metanephric mesenchyme developmentGO:00720759.8PAX2, WT1
4metanephric epithelium developmentGO:00722079.7PAX2, WT1
5camera-type eye developmentGO:00430109.5PAX2, WT1
6substrate adhesion-dependent cell spreadingGO:00344469.3LAMB1, LAMC1

Sources for Diffuse Mesangial Sclerosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet