DMS
MCID: DFF021
MIFTS: 35

Diffuse Mesangial Sclerosis (DMS) malady

Genetic diseases category

Summaries for Diffuse Mesangial Sclerosis

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32MalaCards
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MalaCards: Diffuse Mesangial Sclerosis, also known as mesangial sclerosis, diffuse, is related to nephrotic syndrome and denys-drash syndrome. An important gene associated with Diffuse Mesangial Sclerosis is WT1 (Wilms tumor 1), and among its related pathways are Axon guidance and Cell adhesion Endothelial cell contacts by non-junctional mechanisms. The compounds vitamin d and ribonucleic acid have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Diffuse Mesangial Sclerosis

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42NIH Rare Diseases, 60UMLS, 20GeneTests, 22GTR, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

diffuse mesangial sclerosis 42 60
mesangial sclerosis, diffuse 42 20 22 44
isolated diffuse mesangial sclerosis 42 20
diffuse isolated mesangial sclerosis 42
familial mesangial sclerosis 42
dms 42


Related Diseases for Diffuse Mesangial Sclerosis

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17GeneCards, 18GeneDecks
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Diseases related to Diffuse Mesangial Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome31.1PAX2, LAMB2, PLCE1, WT1
2denys-drash syndrome30.6PDGFA, PAX2, WT1
3breast cancer29.8KRBOX4, PDGFA, PAX2, TGFB1
4myotonic dystrophy10.4
5diabetes mellitus10.4
6microcephaly10.3
7nephrotic syndrome type 310.3
8nephrotic syndrome, type 410.3
9sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis10.3
10familial nephrotic syndrome10.2
11alpha chain disease10.2
12kawasaki disease10.2
13cataract10.2
14collagen disease10.2
15pierson syndrome10.2
16maturity-onset diabetes of the young10.2
17arthritis10.2
18rheumatoid arthritis10.2
19diabetes insipidus10.1
20dermatomyositis10.1
21vaccinia10.0
22dermatitis10.0
23interstitial lung disease10.0
24neuropathy10.0
25psoriasis10.0
26type 2 diabetes mellitus10.0
27myotonic dystrophy type 110.0
28epidermolysis bullosa10.0LAMB2
29nephrosis10.0LAMB2
30thymoma10.0STK16
31renal dysplasia10.0PAX2
32kidney cancer10.0PAX2
33aniridia10.0WT1
34renal agenesis10.0PAX2
35nephroblastoma10.0PAX2, WT1
36focal segmental glomerulosclerosis10.0WT1, PAX2
37prostate cancer10.0PAX2, TGFB1
38malignant mesothelioma10.0PDGFA, WT1
39glioblastoma multiforme10.0TGFB1, PDGFA
40proteinuria10.0TGFB1, PAX2, WT1
41chronic kidney failure10.0WT1, TGFB1, PAX2
42ureteral obstruction10.0TGFB1, PDGFA
43wilms tumor10.0WT1, PDGFA, PAX2, KRBOX4
44primary hyperoxaluria10.0PDGFA, PAX2, TGFB1, WT1
45lung cancer10.0PDGFA, TGFB1, LAMB1
46melanoma10.0TGFB1, LAMC1, PDGFA
47adenocarcinoma10.0PAX2, LAMB1, PDGFA, WT1, TGFB1
48diabetic nephropathy9.9
49melancholia9.9
50laryngeal small cell carcinoma9.9

Graphical network of the top 20 diseases related to Diffuse Mesangial Sclerosis:



Diseases related to diffuse mesangial sclerosis

Clinical Features for Diffuse Mesangial Sclerosis

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Drugs & Therapeutics for Diffuse Mesangial Sclerosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Diffuse Mesangial Sclerosis

Search CenterWatch for Diffuse Mesangial Sclerosis

Genetic Tests for Diffuse Mesangial Sclerosis

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20GeneTests, 22GTR
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Genetic tests related to Diffuse Mesangial Sclerosis:

id Genetic test Affiliating Genes
1 Diffuse Mesangial Sclerosis Syndromes (dms)20 WT1
2 Isolated Diffuse Mesangial Sclerosis20 WT1
3 Diffuse Mesangial Sclerosis22

Anatomical Context for Diffuse Mesangial Sclerosis

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Animal Models for Diffuse Mesangial Sclerosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Diffuse Mesangial Sclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1WT1, PLCE1, LAMC1, TGFB1, PDGFA
2MP:00053678.0TGFB1, PDGFA, WT1, PAX2, LAMC1, LAMB2
3MP:00053807.9LAMC1, PAX2, WT1, PDGFA, LAMB1, TGFB1
4MP:00053857.8TGFB1, WT1, LAMC1, PAX2, PDGFA, PLCE1
5MP:00107687.5TGFB1, LAMB2, LAMC1, LAMB1, PAX2, WT1

Publications for Diffuse Mesangial Sclerosis

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Genetic Variations for Diffuse Mesangial Sclerosis

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Expression for genes affiliated with Diffuse Mesangial Sclerosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diffuse Mesangial Sclerosis

Search GEO for disease gene expression data for Diffuse Mesangial Sclerosis.

Pathways for genes affiliated with Diffuse Mesangial Sclerosis

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53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.6LAMB1, LAMC1
2
Cell adhesion Endothelial cell contacts by non-junctional mechanisms
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9.6LAMB1, LAMC1
3
Cell adhesion Cell-matrix glycoconjugates
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9.6LAMB1, LAMC1
49.5TGFB1, PAX2
59.4PDGFA, TGFB1
69.3LAMB2, LAMB1, LAMC1
79.3LAMB1, LAMB2, LAMC1
89.3LAMB1, LAMC1, LAMB2
9
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9.3LAMB1, LAMC1, LAMB2
109.1TGFB1, WT1, PDGFA
119.1TGFB1, LAMC1, LAMB1
128.8TGFB1, LAMB2, LAMC1, LAMB1
13
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8.8LAMB1, TGFB1, LAMC1, LAMB2
14
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8.8PDGFA, LAMB2, LAMC1, LAMB1
15
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8.8PDGFA, LAMB1, LAMC1, LAMB2
168.8LAMC1, LAMB1, PDGFA, LAMB2
17
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8.8PDGFA, LAMC1, LAMB2, LAMB1
188.3LAMB2, LAMC1, LAMB1, PDGFA, TGFB1
19
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7.9PLCE1, TGFB1, LAMB2, LAMC1, LAMB1, PDGFA
20
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7.9TGFB1, PLCE1, LAMB2, LAMC1, LAMB1, PDGFA

Compounds for genes affiliated with Diffuse Mesangial Sclerosis

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44Novoseek
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Compounds related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vitamin d449.1TGFB1, WT1, PDGFA
2ribonucleic acid449.0TGFB1, PDGFA, WT1
312-o-tetradecanoylphorbol 13-acetate448.8TGFB1, WT1, PDGFA
4oligonucleotide448.5PDGFA, WT1, TGFB1, KRBOX4

GO Terms for genes affiliated with Diffuse Mesangial Sclerosis

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16Gene Ontology
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Cellular components related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1laminin-11 complexGO:0432609.9LAMC1, LAMB2
2laminin-10 complexGO:0432599.8LAMB1, LAMC1
3laminin-1 complexGO:0056069.7LAMC1, LAMB1
4platelet alpha granule lumenGO:0310939.4TGFB1, PDGFA
5basement membraneGO:0056049.4LAMB2, LAMC1, LAMB1
6microvillusGO:0059029.3PDGFA, TGFB1
7extracellular matrixGO:0310129.3LAMC1, LAMB1, LAMB2
8extracellular spaceGO:0056158.3PDGFA, LAMB1, LAMC1, TGFB1

Biological processes related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glomerulus developmentGO:03283510.1WT1, PLCE1
2metanephric epithelium developmentGO:07220710.1WT1, PAX2
3mesenchymal to epithelial transitionGO:06023110.1WT1, PAX2
4metanephric mesenchyme developmentGO:07207510.0WT1, PAX2
5camera-type eye developmentGO:0430109.8PAX2, WT1
6substrate adhesion-dependent cell spreadingGO:0344469.8LAMB1, LAMC1
7positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.8TGFB1, PAX2
8branching involved in ureteric bud morphogenesisGO:0016589.8WT1, PAX2
9endoderm developmentGO:0074929.7TGFB1, LAMC1
10protein kinase B signaling cascadeGO:0434919.7PAX2, TGFB1
11ureteric bud developmentGO:0016579.7WT1, TGFB1
12inner ear developmentGO:0488399.5PDGFA, TGFB1
13positive regulation of MAP kinase activityGO:0434069.3PDGFA, TGFB1
14positive regulation of cell migrationGO:0303359.3PDGFA, LAMB1, TGFB1
15epidermal growth factor receptor signaling pathwayGO:0071739.3TGFB1, PDGFA, PLCE1
16positive regulation of cell divisionGO:0517819.1PDGFA, TGFB1
17positive regulation of epithelial cell proliferationGO:0506799.0TGFB1, LAMC1, LAMB1, PAX2
18extracellular matrix organizationGO:0301988.6PDGFA, LAMB1, LAMC1, TGFB1, LAMB2

Molecular functions related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycosphingolipid bindingGO:0432089.5LAMC1, LAMB1
2C2H2 zinc finger domain bindingGO:0707429.5PAX2, WT1
3enzyme bindingGO:0198999.3TGFB1, LAMB1, PLCE1

Products for genes affiliated with Diffuse Mesangial Sclerosis

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  • Antibodies
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Sources for Diffuse Mesangial Sclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet