MCID: DFF021
MIFTS: 40

Diffuse Mesangial Sclerosis malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Diffuse Mesangial Sclerosis

About this section

Aliases & Descriptions for Diffuse Mesangial Sclerosis:

Name: Diffuse Mesangial Sclerosis 45 65
Diffuse Mesangial Sclerosis Syndromes 22 24
Isolated Diffuse Mesangial Sclerosis 45 22
Familial Mesangial Sclerosis 45 65
Mesangial Sclerosis, Diffuse 45 47
 
Nephrotic Syndrome, Early Onset with Diffuse Mesangial Sclerosis 45
Diffuse Isolated Mesangial Sclerosis 45
Idms 22
Dms 45

Classifications:



External Ids:

UMLS65 C0268747, C3489732

Summaries for Diffuse Mesangial Sclerosis

About this section
MalaCards based summary: Diffuse Mesangial Sclerosis, also known as diffuse mesangial sclerosis syndromes, is related to nephrotic syndrome, type 4 and pierson syndrome. An important gene associated with Diffuse Mesangial Sclerosis is WT1 (Wilms Tumor 1), and among its related pathways are G-protein signaling_RhoB regulation pathway and Nephrin/Neph1 signaling in the kidney podocyte. Affiliated tissues include endothelial, brain and breast, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Related Diseases for Diffuse Mesangial Sclerosis

About this section

Diseases related to Diffuse Mesangial Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome, type 432.3NPHS1, PAX2, WT1
2pierson syndrome30.9LAMB1, LAMB2
3sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis12.2
4familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis12.2
5dermatomyositis11.2
6myotonic dystrophy 111.2
7epidermolysis bullosa simplex, dowling-meara type11.2
8diaphyseal medullary stenosis with malignant fibrous histiocytoma10.9
9childhood type dermatomyositis10.9
10neonatal dermatomyositis10.9
11denys-drash syndrome10.8
12rheumatoid arthritis10.6
13maturity-onset diabetes of the young10.5
14diabetes insipidus10.5
15nephrotic syndrome10.4
16nephrotic syndrome, type 310.4
17nephrogenic adenofibroma10.4PAX2, WT1
18gastroesophageal junction adenocarcinoma10.3PAX2, WT1
19liver sarcoma10.3PAX2, WT1
20myotonic dystrophy10.3
21familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation10.3ARHGDIA, PLCE1, WT1
22breast pericanalicular fibroadenoma10.2PAX2, WT1
23nephrotic syndrome, type 810.2
24microcephaly10.0
25arthritis10.0
26hepatitis c virus10.0
27neuropathy9.9
28breast cancer9.9
29multiple myeloma9.9
30myeloma9.9
31kawasaki disease9.9
32cataract9.9
33autonomic neuropathy9.9
34dermatitis9.9
35interstitial lung disease9.9
36vaccinia9.9
37lung disease9.9
38psoriasis9.9
39endotheliitis9.9
40h. pylori infection9.8
41muscular dystrophy-dystroglycanopathy , type c, 59.8
42duchenne muscular dystrophy9.8
43calpainopathy9.8
44osteoarthritis9.8
45pulmonary emphysema9.8
46influenza9.8
47wolfram syndrome9.8
48fetal erythroblastosis9.8LAMB1, NPHS1
49pfeiffer syndrome type 39.8NPHS1, NPHS2
50spastic hemiplegia9.7NPHS1, NPHS2

Graphical network of the top 20 diseases related to Diffuse Mesangial Sclerosis:



Diseases related to diffuse mesangial sclerosis

Symptoms for Diffuse Mesangial Sclerosis

About this section

Drugs & Therapeutics for Diffuse Mesangial Sclerosis

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Diffuse Mesangial Sclerosis

Genetic Tests for Diffuse Mesangial Sclerosis

About this section

Genetic tests related to Diffuse Mesangial Sclerosis:

id Genetic test Affiliating Genes
1 Diffuse Mesangial Sclerosis Syndromes (dms)22 WT1
2 Isolated Diffuse Mesangial Sclerosis22 WT1

Anatomical Context for Diffuse Mesangial Sclerosis

About this section

MalaCards organs/tissues related to Diffuse Mesangial Sclerosis:

33
Endothelial, Brain, Breast, Bone, Liver, Neutrophil

Animal Models for Diffuse Mesangial Sclerosis or affiliated genes

About this section

MGI Mouse Phenotypes related to Diffuse Mesangial Sclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.9ARHGDIA, LAMB2, LAMC1, NPHS1, NPHS2, PAX2
2MP:00053857.9ARHGDIA, LAMC1, NPHS2, PAX2, PLCE1, WT1
3MP:00107687.1ARHGDIA, LAMB1, LAMB2, LAMC1, NPHS1, NPHS2

Publications for Diffuse Mesangial Sclerosis

About this section

Articles related to Diffuse Mesangial Sclerosis:

(show all 37)
idTitleAuthorsYear
1
AJKD Atlas of Renal Pathology: Diffuse Mesangial Sclerosis. (26408240)
2015
2
Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly increased urinary podocyte excretion. (24856573)
2014
3
Diffuse mesangial sclerosis - Report of two cases. (23087559)
2012
4
Respiratory-chain deficiency presenting as diffuse mesangial sclerosis with NPHS3 mutation. (21365190)
2011
5
Mutations in phospholipase C epsilon 1 are not sufficient to cause diffuse mesangial sclerosis. (19037252)
2009
6
Evolutive study of children with diffuse mesangial sclerosis. (19066977)
2009
7
Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). (18065803)
2008
8
Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis. (16523262)
2006
9
Two cases of isolated diffuse mesangial sclerosis with WT1 mutations. (16479084)
2006
10
Congenital nephrotic syndrome: report of an infant with diffuse mesangial sclerosis. (14964988)
2003
11
Isolated diffuse mesangial sclerosis and Wilms tumor suppressor gene. (11241056)
2001
12
Immunohistochemical analysis of molecular events in tubulo-interstitial fibrosis in a mouse model of diffuse mesangial sclerosis (ICGN strain). (11307931)
2001
13
Diffuse mesangial sclerosis presenting as infantile nephrotic syndrome. (11418734)
2001
14
Glomerular extracellular matrix and growth factors in diffuse mesangial sclerosis. (11405118)
2001
15
Absence of correlation between genotype and the severity of diffuse mesangial sclerosis in Denys-Drash syndrome. (10805477)
2000
16
Nephrotic mice (ICGN strain): a model of diffuse mesangial sclerosis in infantile nephrotic syndrome. (10085455)
1999
17
WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis. (9916932)
1999
18
Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database. (9529364)
1998
19
Isolated diffuse mesangial sclerosis in three siblings. (9546709)
1998
20
Diffuse mesangial sclerosis: association with unreported congenital anomalies and placental enlargement. (9894834)
1998
21
Diffuse mesangial sclerosis associated with Kawasaki disease: an analysis of alpha chains (alpha 1-alpha 6) of human type IV collagen in the renal basement membrane. (9230914)
1997
22
Congenital nephrotic syndrome, diffuse mesangial sclerosis, and bilateral cataract. (8971891)
1996
23
Hypoplastic tubules occurring in diffuse mesangial sclerosis. (8970202)
1996
24
Diffuse mesangial sclerosis: a unique type of congenital and infantile nephrotic syndrome. (8684541)
1996
25
Do children with diffuse mesangial sclerosis in association with mutations of the Wilm's tumour suppressor gene (WT1) require bilateral nephrectomy? (7794729)
1995
26
Microcephaly and congenital nephrotic syndrome owing to diffuse mesangial sclerosis: an autosomal recessive syndrome. (8182716)
1994
27
Diffuse mesangial sclerosis: a congenital glomerulopathy with nephrotic syndrome. (8381254)
1993
28
Should bilateral nephrectomy be carried out in all children with diffuse mesangial sclerosis prior to renal transplantation in view of the connection with Drash syndrome and therefore the risk of a Wilms' tumour developing? (1319726)
1992
29
Diffuse mesangial sclerosis in a fetus. (1889151)
1991
30
Clinical quiz. Congenital nephrotic syndrome, microcephaly, brain malformations and diaphragmatic abnormality associated with histological features of diffuse mesangial sclerosis. (1911117)
1991
31
Congenital/infantile nephrotic syndrome with diffuse mesangial sclerosis: relationship with Drash syndrome. (2762352)
1989
32
Clinicopathological quiz. Wilms' tumour with renal failure due to diffuse mesangial sclerosis. (2856390)
1987
33
Diffuse mesangial sclerosis--light, immunofluorescent and electronmicroscopy findings. (3897087)
1985
34
Nephrotic syndrome with diffuse mesangial sclerosis in identical twins. (6682143)
1983
35
Diffuse mesangial sclerosis and ocular abnormalities in two siblings. (6809680)
1982
36
Familial early-onset nephrotic syndrome: diffuse mesangial sclerosis. Clinico-pathological study of a kindred. (7180443)
1982
37
Infantile nephrotic syndrome with diffuse mesangial sclerosis: a disturbance of glomerular basement membrane development? (7379364)
1980

Variations for Diffuse Mesangial Sclerosis

About this section

Expression for genes affiliated with Diffuse Mesangial Sclerosis

About this section
Search GEO for disease gene expression data for Diffuse Mesangial Sclerosis.

Pathways for genes affiliated with Diffuse Mesangial Sclerosis

About this section

GO Terms for genes affiliated with Diffuse Mesangial Sclerosis

About this section

Cellular components related to Diffuse Mesangial Sclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1laminin-1 complexGO:00056069.7LAMB1, LAMC1
2basement membraneGO:00056049.0LAMB1, LAMB2, LAMC1

Biological processes related to Diffuse Mesangial Sclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular visceral epithelial cell developmentGO:007224910.2LAMB2, NPHS2
2glomerulus developmentGO:003283510.1PLCE1, WT1
3metanephric mesenchyme developmentGO:00720759.8PAX2, WT1
4metanephric epithelium developmentGO:00722079.7PAX2, WT1
5camera-type eye developmentGO:00430109.5PAX2, WT1
6substrate adhesion-dependent cell spreadingGO:00344469.3LAMB1, LAMC1

Sources for Diffuse Mesangial Sclerosis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet