DMS
MCID: DFF021
MIFTS: 49

Diffuse Mesangial Sclerosis (DMS) malady

Genetic diseases, Rare diseases, Nephrological diseases categories
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Summaries for Diffuse Mesangial Sclerosis

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MalaCards based summary: Diffuse Mesangial Sclerosis, also known as mesangial sclerosis, diffuse, is related to nephrotic syndrome and pierson syndrome. An important gene associated with Diffuse Mesangial Sclerosis is WT1 (Wilms tumor 1), and among its related pathways are Regulation of Telomerase and S-1P Stimulated Signaling. The compounds tripeptide and tetracycline have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are vision/eye and muscle.

Aliases & Classifications for Diffuse Mesangial Sclerosis

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Sources:
42NIH Rare Diseases, 20GeneTests, 22GTR, 44Novoseek, 62UMLS
See all sources

Diffuse Mesangial Sclerosis, Aliases & Descriptions:

Name: Diffuse Mesangial Sclerosis 42 62
Mesangial Sclerosis, Diffuse 42 20 22 44
Isolated Diffuse Mesangial Sclerosis 42 20
Nephrotic Syndrome, Early Onset with Diffuse Mesangial Sclerosis 42
 
Diffuse Isolated Mesangial Sclerosis 42
Familial Mesangial Sclerosis 42
Dms 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Nephrological diseases


Related Diseases for Diffuse Mesangial Sclerosis

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Diseases related to Diffuse Mesangial Sclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1nephrotic syndrome31.1LAMB2, PAX2, PLCE1, WT1
2pierson syndrome31.0LAMB2
3denys-drash syndrome30.6WT1, PDGFA, PAX2
4muscular dystrophy30.0LAMB1, LAMB2
5wilms tumor30.0PAX2, PDGFA, KRBOX4, WT1
6myotonic dystrophy10.5
7diabetes mellitus10.5
8nephrosis10.4LAMB2
9microcephaly10.4
10nephrotic syndrome type 310.4
11sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis10.4
12familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis10.4
13arthritis10.2
14rheumatoid arthritis10.2
15cataract10.2
16kawasaki disease10.2
17nephrotic syndrome, type 410.2
18focal segmental glomerulosclerosis10.2WT1, PAX2
19nephroblastoma10.2PAX2, WT1
20diabetes insipidus10.2
21maturity-onset diabetes of the young10.2
22dermatomyositis10.2
23type 2 diabetes mellitus10.1
24myotonic dystrophy type 110.1
25vaccinia10.1
26dermatitis10.1
27interstitial lung disease10.1
28neuropathy10.1
29psoriasis10.1
30endotheliitis10.1
31proteinuria10.0TGFB1, PAX2, WT1
32primary hyperoxaluria10.0TGFB1, PAX2, WT1
33chronic kidney failure10.0TGFB1, PAX2, WT1
34ureteral obstruction10.0PDGFA, TGFB1
35acute lymphoblastic leukemia9.9
36celiac disease9.9
37childhood type dermatomyositis9.9
38diabetic nephropathy9.9
39diabetic retinopathy9.9
40facioscapulohumeral muscular dystrophy9.9
41hematopoietic stem cell transplantation9.9
42leukemia9.9
43multiple sclerosis9.9
44renal cell carcinoma9.9
45melancholia9.9
46neonatal diabetes mellitus9.9
47hypoglycemia9.9
48ulnar neuropathy9.9
49oculocutaneous albinism9.9
50myotonic dystrophy type 29.9

Graphical network of the top 20 diseases related to Diffuse Mesangial Sclerosis:



Diseases related to diffuse mesangial sclerosis

Symptoms for Diffuse Mesangial Sclerosis

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Drugs & Therapeutics for Diffuse Mesangial Sclerosis

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Drug clinical trials:

Search ClinicalTrials for Diffuse Mesangial Sclerosis

Search NIH Clinical Center for Diffuse Mesangial Sclerosis

Genetic Tests for Diffuse Mesangial Sclerosis

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Genetic tests related to Diffuse Mesangial Sclerosis:

id Genetic test Affiliating Genes
1 Diffuse Mesangial Sclerosis Syndromes (dms)20 WT1
2 Isolated Diffuse Mesangial Sclerosis20 WT1
3 Diffuse Mesangial Sclerosis22

Anatomical Context for Diffuse Mesangial Sclerosis

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MalaCards organs/tissues related to Diffuse Mesangial Sclerosis:

32
Brain

Animal Models for Diffuse Mesangial Sclerosis or affiliated genes

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MGI Mouse Phenotypes related to Diffuse Mesangial Sclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.8PAX2, TGFB1, LAMC1, LAMB2
2MP:00053698.5LAMC1, TGFB1, PLCE1, PDGFA, WT1
3MP:00053888.4LAMC1, TGFB1, PDGFA, WT1
4MP:00053898.3LAMC1, TGFB1, PAX2, PDGFA, WT1
5MP:00053678.2WT1, PDGFA, PAX2, TGFB1, LAMC1, LAMB2
6MP:00053858.1LAMC1, TGFB1, PAX2, PLCE1, PDGFA, WT1
7MP:00053808.1LAMC1, LAMB1, TGFB1, PAX2, PDGFA, WT1
8MP:00053767.9LAMB2, LAMC1, TGFB1, PLCE1, PDGFA, WT1
9MP:00107687.6LAMB2, LAMC1, LAMB1, TGFB1, PAX2, PDGFA

Publications for Diffuse Mesangial Sclerosis

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Articles related to Diffuse Mesangial Sclerosis:

(show all 36)
idTitleAuthorsYear
1
Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly increased urinary podocyte excretion. (24856573)
2014
2
Diffuse mesangial sclerosis - Report of two cases. (23087559)
2012
3
Respiratory-chain deficiency presenting as diffuse mesangial sclerosis with NPHS3 mutation. (21365190)
2011
4
Mutations in phospholipase C epsilon 1 are not sufficient to cause diffuse mesangial sclerosis. (19037252)
2009
5
Evolutive study of children with diffuse mesangial sclerosis. (19066977)
2009
6
Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). (18065803)
2008
7
Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis. (16523262)
2006
8
Two cases of isolated diffuse mesangial sclerosis with WT1 mutations. (16479084)
2006
9
Congenital nephrotic syndrome: report of an infant with diffuse mesangial sclerosis. (14964988)
2003
10
Isolated diffuse mesangial sclerosis and Wilms tumor suppressor gene. (11241056)
2001
11
Immunohistochemical analysis of molecular events in tubulo-interstitial fibrosis in a mouse model of diffuse mesangial sclerosis (ICGN strain). (11307931)
2001
12
Diffuse mesangial sclerosis presenting as infantile nephrotic syndrome. (11418734)
2001
13
Glomerular extracellular matrix and growth factors in diffuse mesangial sclerosis. (11405118)
2001
14
Absence of correlation between genotype and the severity of diffuse mesangial sclerosis in Denys-Drash syndrome. (10805477)
2000
15
Nephrotic mice (ICGN strain): a model of diffuse mesangial sclerosis in infantile nephrotic syndrome. (10085455)
1999
16
WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis. (9916932)
1999
17
Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database. (9529364)
1998
18
Isolated diffuse mesangial sclerosis in three siblings. (9546709)
1998
19
Diffuse mesangial sclerosis: association with unreported congenital anomalies and placental enlargement. (9894834)
1998
20
Diffuse mesangial sclerosis associated with Kawasaki disease: an analysis of alpha chains (alpha 1-alpha 6) of human type IV collagen in the renal basement membrane. (9230914)
1997
21
Congenital nephrotic syndrome, diffuse mesangial sclerosis, and bilateral cataract. (8971891)
1996
22
Hypoplastic tubules occurring in diffuse mesangial sclerosis. (8970202)
1996
23
Diffuse mesangial sclerosis: a unique type of congenital and infantile nephrotic syndrome. (8684541)
1996
24
Do children with diffuse mesangial sclerosis in association with mutations of the Wilm's tumour suppressor gene (WT1) require bilateral nephrectomy? (7794729)
1995
25
Microcephaly and congenital nephrotic syndrome owing to diffuse mesangial sclerosis: an autosomal recessive syndrome. (8182716)
1994
26
Diffuse mesangial sclerosis: a congenital glomerulopathy with nephrotic syndrome. (8381254)
1993
27
Should bilateral nephrectomy be carried out in all children with diffuse mesangial sclerosis prior to renal transplantation in view of the connection with Drash syndrome and therefore the risk of a Wilms' tumour developing? (1319726)
1992
28
Diffuse mesangial sclerosis in a fetus. (1889151)
1991
29
Clinical quiz. Congenital nephrotic syndrome, microcephaly, brain malformations and diaphragmatic abnormality associated with histological features of diffuse mesangial sclerosis. (1911117)
1991
30
Congenital/infantile nephrotic syndrome with diffuse mesangial sclerosis: relationship with Drash syndrome. (2762352)
1989
31
Clinicopathological quiz. Wilms' tumour with renal failure due to diffuse mesangial sclerosis. (2856390)
1987
32
Diffuse mesangial sclerosis--light, immunofluorescent and electronmicroscopy findings. (3897087)
1985
33
Nephrotic syndrome with diffuse mesangial sclerosis in identical twins. (6682143)
1983
34
Diffuse mesangial sclerosis and ocular abnormalities in two siblings. (6809680)
1982
35
Familial early-onset nephrotic syndrome: diffuse mesangial sclerosis. Clinico-pathological study of a kindred. (7180443)
1982
36
Infantile nephrotic syndrome with diffuse mesangial sclerosis: a disturbance of glomerular basement membrane development? (7379364)
1980

Variations for Diffuse Mesangial Sclerosis

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Expression for genes affiliated with Diffuse Mesangial Sclerosis

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Expression patterns in normal tissues for genes affiliated with Diffuse Mesangial Sclerosis

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Pathways for genes affiliated with Diffuse Mesangial Sclerosis

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Pathways related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TGFB1, WT1
29.6PDGFA, PLCE1
39.6LAMC1, LAMB1
49.6LAMC1, LAMB1
59.6TGFB1, PAX2
69.4PDGFA, TGFB1
7
Show member pathways
9.3LAMB1, LAMC1, LAMB2
8
Show member pathways
9.3LAMB1, LAMC1, LAMB2
99.3LAMB2, LAMC1, LAMB1
109.3LAMB2, LAMC1, LAMB1
119.1TGFB1, PDGFA, WT1
12
Show member pathways
9.1PDGFA, PLCE1, TGFB1
13
Show member pathways
9.1PDGFA, PLCE1, TGFB1
149.1LAMC1, LAMB1, TGFB1
15
Show member pathways
9.1TGFB1, LAMB1, LAMC1
168.7LAMB2, LAMC1, LAMB1, TGFB1
178.7TGFB1, LAMB1, LAMC1, LAMB2
18
Show member pathways
8.7TGFB1, LAMB1, LAMC1, LAMB2
19
Show member pathways
8.7TGFB1, LAMB1, LAMC1, LAMB2
208.7LAMB2, LAMC1, LAMB1, PDGFA
21
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.7LAMB2, LAMC1, LAMB1, PDGFA
22
Show member pathways
8.2PDGFA, TGFB1, LAMB1, LAMC1, LAMB2
238.2LAMB2, LAMC1, LAMB1, TGFB1, PDGFA
24
Show member pathways
Proteogylcan syndecan-mediated signaling events37
8.2PDGFA, TGFB1, LAMB1, LAMC1, LAMB2
25
Show member pathways
7.9LAMB2, LAMC1, LAMB1, TGFB1, PLCE1, PDGFA
26
Show member pathways
7.9LAMB2, LAMC1, LAMB1, TGFB1, PLCE1, PDGFA

Compounds for genes affiliated with Diffuse Mesangial Sclerosis

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Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1tripeptide449.9WT1, LAMB2
2tetracycline44 1110.7WT1, TGFB1
3procollagen449.4TGFB1, PDGFA
4ribonucleic acid449.4WT1, PDGFA, TGFB1
512-o-tetradecanoylphorbol 13-acetate449.4TGFB1, PDGFA, WT1
6vitamin d449.3WT1, PDGFA, TGFB1
7paraffin449.2WT1, PDGFA, TGFB1
8losartan44 50 28 1112.1PDGFA, TGFB1
9heparin44 28 24 1112.1PDGFA, LAMC1, LAMB2
10retinoic acid44 249.9LAMB1, TGFB1, PDGFA, WT1
11oligonucleotide448.6WT1, KRBOX4, PDGFA, TGFB1
12estrogen448.5TGFB1, PDGFA, KRBOX4, WT1

GO Terms for genes affiliated with Diffuse Mesangial Sclerosis

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Cellular components related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1laminin-11 complexGO:0432609.9LAMC1, LAMB2
2laminin-10 complexGO:0432599.8LAMB1, LAMC1
3laminin-1 complexGO:0056069.7LAMC1, LAMB1
4basement membraneGO:0056049.4LAMB1, LAMC1, LAMB2
5microvillusGO:0059029.3PDGFA, TGFB1
6extracellular matrixGO:0310129.3LAMB1, LAMC1, LAMB2
7platelet alpha granule lumenGO:0310939.1TGFB1, PDGFA
8extracellular spaceGO:0056158.6PDGFA, TGFB1, LAMB1, LAMC1
9extracellular regionGO:0055768.2LAMB2, LAMC1, LAMB1, TGFB1, PDGFA

Biological processes related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glomerulus developmentGO:03283510.2PLCE1, WT1
2metanephric epithelium developmentGO:07220710.2WT1, PAX2
3mesenchymal to epithelial transitionGO:06023110.2WT1, PAX2
4metanephric mesenchyme developmentGO:07207510.2WT1, PAX2
5camera-type eye developmentGO:04301010.1PAX2, WT1
6branching involved in ureteric bud morphogenesisGO:00165810.0WT1, PAX2
7ureteric bud developmentGO:0016579.9WT1, TGFB1
8substrate adhesion-dependent cell spreadingGO:0344469.9LAMB1, LAMC1
9positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.9PAX2, TGFB1
10protein kinase B signalingGO:0434919.9PAX2, TGFB1
11endoderm developmentGO:0074929.8TGFB1, LAMC1
12inner ear developmentGO:0488399.7PDGFA, TGFB1
13positive regulation of MAP kinase activityGO:0434069.7PDGFA, TGFB1
14positive regulation of cell divisionGO:0517819.6PDGFA, TGFB1
15response to woundingGO:0096119.6TGFB1, PDGFA
16axon guidanceGO:0074119.5LAMB2, LAMC1, LAMB1
17positive regulation of protein kinase B signalingGO:0518979.4TGFB1, PDGFA
18epidermal growth factor receptor signaling pathwayGO:0071739.4TGFB1, PLCE1, PDGFA
19cell adhesionGO:0071559.4LAMB1, LAMC1, LAMB2
20positive regulation of cell migrationGO:0303359.4PDGFA, TGFB1, LAMB1
21negative regulation of transcription, DNA-templatedGO:0458929.3WT1, PAX2, TGFB1
22response to estradiolGO:0323559.3PDGFA, TGFB1
23positive regulation of transcription, DNA-templatedGO:0458939.3WT1, PAX2, TGFB1
24platelet degranulationGO:0025769.1PDGFA, TGFB1
25positive regulation of epithelial cell proliferationGO:0506799.1PAX2, TGFB1, LAMB1, LAMC1
26extracellular matrix organizationGO:0301988.6LAMB2, LAMC1, LAMB1, TGFB1, PDGFA

Molecular functions related to Diffuse Mesangial Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C2H2 zinc finger domain bindingGO:0707429.8WT1, PAX2
2glycosphingolipid bindingGO:0432089.7LAMB1, LAMC1
3RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.6WT1, STK16
4extracellular matrix structural constituentGO:0052019.3LAMB1, LAMC1
5enzyme bindingGO:0198999.1LAMB1, TGFB1, PLCE1

Products for genes affiliated with Diffuse Mesangial Sclerosis

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Sources for Diffuse Mesangial Sclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet