Diffuse Scleroderma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Diffuse Scleroderma

MalaCards based summary: Diffuse Scleroderma, also known as diffuse cutaneous systemic sclerosis, is related to interstitial lung disease and systemic scleroderma, and has symptoms including dry skin, acrocyanosis and respiratory insufficiency. An important gene associated with Diffuse Scleroderma is CTGF (connective tissue growth factor), and among its related pathways are amb2 Integrin signaling and Development TGF beta receptor signaling. The compounds des-arg(10)-kallidin and kallidin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Diffuse Scleroderma

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ⁶¹UMLS, ⁴⁸Orphanet, ⁵⁶SNOMED-CT, ³⁴MeSH, ²⁷ICD10 via Orphanet
See all sources

Diffuse Scleroderma, Aliases & Descriptions:

Name: Diffuse Scleroderma ⁹ ⁴² ⁶¹

Diffuse Cutaneous Systemic Sclerosis ⁴² ⁴⁸ ⁶¹

Diffuse Systemic Sclerosis ⁹ ⁴² ⁶¹

Diffuse Cutaneous Systemic Scleroderma ⁴² ⁴⁸

Sudden Onset Scleroderma ⁴² ⁶¹

Progressive Cutaneous Systemic Scleroderma ⁴⁸

Progressive Cutaneous Systemic Sclerosis ⁴⁸

Systemic Sclerosis, Diffuse ⁹

Dcssc ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases, Respiratory diseases, Bone diseases, Skin diseases, Immune diseases

ICD10: ²⁷

Diseases of the musculoskeletal system and connective tissue

Systemic connective tissue disorders

Systemic sclerosis

Progressive systemic sclerosis

Orphanet: ⁴⁸

Rare renal diseases

Rare respiratory diseases

Rare systemic and rhumatological diseases

Rare skin diseases

Characteristics (Orphanet epidemiological data):

⁴⁸

diffuse cutaneous systemic sclerosis:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult

External Ids:

Disease Ontology⁹ DOID:1580

MeSH³⁴ C536175, D045743

SNOMED-CT⁵⁶ 444133002, 128460000

ICD10 via Orphanet²⁷ M34.0

UMLS⁶¹ C1258104

Related Diseases for Diffuse Scleroderma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Diffuse Scleroderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 95)

id	Related Disease	Score	Top Affiliating Genes
1	interstitial lung disease	30.7	BMP6, TGFB1
2	systemic scleroderma	30.5	CTGF, IRF5
3	skin disease	30.3	HLA-DRB1, TGFB1
4	connective tissue disease	30.2	TGFB1, HLA-DRB1
5	hypertension	30.2	KNG1, CAV1, TGFB1
6	hepatitis	30.1	TGFB1, HLA-DRB1
7	systemic lupus erythematosus	30.1	HLA-DRB1, FBL, IRF5
8	pulmonary fibrosis	30.0	TGFB1, BMP6, CAV1, FBL, CTGF
9	arthritis	29.9	KNG1, TGFB1, CTGF, HLA-DRB1
10	ovarian cancer	29.8	CAV1, CTGF, BMP6, TGFB1
11	breast cancer	29.4	BMP6, TGFB1, CCR6, CAV1, CTGF
12	rheumatoid arthritis	29.2	CTGF, IRF5, CCR6, BMP6, HLA-DRB1
13	scleroderma	11.0
14	lupus erythematosus	10.3
15	telangiectasis	10.3	FBL, BMP6
16	telangiectasia, hereditary hemorrhagic, type 5	10.3	TGFB1, BMP6
17	crest syndrome	10.3
18	esophagitis	10.3
19	ureteral disease	10.3	TGFB1, CTGF
20	myelofibrosis	10.3	TGFB1, BMP6
21	gingival overgrowth	10.2	CTGF, TGFB1
22	biliary atresia	10.2	CTGF, TGFB1
23	malaria	10.2	HLA-DRB1, KNG1
24	microscopic polyangiitis	10.2
25	bone cancer	10.2	BMP6, CAV1
26	hepatitis b	10.1	HLA-DRB1, TGFB1
27	malignant glioma	10.1	TGFB1, BMP6, KNG1
28	hypertrophic scars	10.1	TGFB1, CTGF, BMP6
29	proliferative vitreoretinopathy	10.1	TGFB1, CTGF, BMP6
30	keloids	10.1	BMP6, TGFB1, CTGF
31	glomerulosclerosis	10.1	CTGF, BMP6, TGFB1
32	primary hyperoxaluria	10.1	CTGF, KNG1, TGFB1
33	idiopathic pulmonary fibrosis	10.1	CTGF, BMP6, TGFB1
34	viral hepatitis	10.1	HLA-DRB1, CTGF
35	cork-handlers' disease	10.1	BMP6, CTGF, TGFB1
36	autoimmune hepatitis	10.1
37	gastric antral vascular ectasia	10.1
38	hepatitis a	10.1
39	steatorrhea	10.1
40	actinomycosis	10.1
41	mixed connective tissue disease	10.1
42	vasculitis	10.1
43	papular mucinosis	10.1
44	cytomegalovirus infection	10.1
45	headache	10.1
46	endotheliitis	10.1
47	cryoglobulinemic vasculitis	10.1
48	atlantoaxial subluxation	10.1
49	aplastic anemia	10.0
50	crohn's disease	10.0

Graphical network of the top 20 diseases related to Diffuse Scleroderma:

Symptoms for Diffuse Scleroderma

Sources:
⁵⁸The Human Phenotype Ontology, ⁴⁸Orphanet
See all sources

Symptoms:

⁴⁸ (show all 31)

anomalies of skin, subcutaneous tissue and mucosae
dry/squaly skin/exfoliation
dermal/subcutaneous infiltration/induration
gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
radiologic lung abnormalities/changes
lung/pulmonary infiltrates
respiratory distress/dyspnea/respiratory failure/lung volume reduction
acrocyanosis/raynaud's phenomenon/vasomotor disorders
pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
autoimmunity/autoimmune reaction/autoantibodies
mouth dryness/xerostomia
multiple caries
chronic skin infection/ulcerations/ulcers/cancrum
telangiectasiae of the skin
feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
malabsorption/chronic diarrhea/steatorrhea

lung fibrosis
dyspareunia/coital pain/vaginal dryness
muscle weakness/flaccidity
contractures/cramps/trismus/tetania/claudication/opisthotonos
osteolysis/osteoclasia/bone destruction/erosions
articular/joint pain/arthralgia
arthritis/synovitis/synovial proliferation
tendon rupture/tendinitis/bursitis/tenosynovitis
nausea/vomiting/regurgitation/merycism/hyperemesis
intestinal transit disorder
pulmonary hypertension
heart/cardiac failure
acute arterial hypertension/hypertensive crisis
renal failure
periarticular tissue anomaly/extraarticular calcifications

HPO human phenotypes related to Diffuse Scleroderma:

(show all 23)

id	Description	Frequency	HPO Source Accession
1	dry skin	hallmark (90%)	HP:0000958
2	acrocyanosis	hallmark (90%)	HP:0001063
3	respiratory insufficiency	hallmark (90%)	HP:0002093
4	pulmonary infiltrates	hallmark (90%)	HP:0002113
5	autoimmunity	hallmark (90%)	HP:0002960
6	xerostomia	typical (50%)	HP:0000217
7	carious teeth	typical (50%)	HP:0000670
8	muscle weakness	typical (50%)	HP:0001324
9	arthritis	typical (50%)	HP:0001369
10	flexion contracture	typical (50%)	HP:0001371
11	malabsorption	typical (50%)	HP:0002024
12	pulmonary fibrosis	typical (50%)	HP:0002206
13	osteolysis	typical (50%)	HP:0002797
14	arthralgia	typical (50%)	HP:0002829
15	feeding difficulties in infancy	typical (50%)	HP:0008872
16	teleangiectasia of the skin	typical (50%)	HP:0100585
17	skin ulcer	typical (50%)	HP:0200042
18	renal insufficiency	occasional (7.5%)	HP:0000083
19	chondrocalcinosis	occasional (7.5%)	HP:0000934
20	congestive heart failure	occasional (7.5%)	HP:0001635
21	nausea and vomiting	occasional (7.5%)	HP:0002017
22	pulmonary hypertension	occasional (7.5%)	HP:0002092
23	hypertensive crisis	occasional (7.5%)	HP:0100735

Drugs & Therapeutics for Diffuse Scleroderma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Diffuse Scleroderma

Search NIH Clinical Center for Diffuse Scleroderma

Genetic Tests for Diffuse Scleroderma

Anatomical Context for Diffuse Scleroderma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Diffuse Scleroderma:

³²

Skin, Lung, Bone, Heart, Skeletal muscle, Kidney, Breast

Animal Models for Diffuse Scleroderma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Diffuse Scleroderma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	7.9	CTGF, KNG1, CAV1, CCR6, IRF5, TGFB1

Publications for Diffuse Scleroderma

Sources:
⁵¹PubMed
See all sources

Articles related to Diffuse Scleroderma:

(show top 50) (show all 77)

id	Title	Authors	Year
1	Successful treatment of steroid and cyclophosphamide-resistant diffuse scleroderma-associated interstitial lung disease with rituximab. (20058013)	Yoo W.H.	2012
2	Skin thickness progression rate: a predictor of mortality and early internal organ involvement in diffuse scleroderma. (20679474)	Domsic R.T.... Medsger T.A.	2011
3	A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity. (19812599)	Sargent J.L.... Whitfield M.L.	2010
4	Squamous cell carcinomas in 2 patients with diffuse scleroderma treated with mycophenolate mofetil. (19208586)	Gulamhusein A.... Pope J.E.	2009
5	Autologous stem cell transplantation in diffuse scleroderma: impact on hand structure and function. (18336540)	Englert H.... Manolios N.	2008
6	High-dose intravenous immunoglobulin infusion as treatment for diffuse scleroderma. (17381465)	Ihn H.... Tamaki K.	2007
7	The health assessment questionnaire (HAQ) is strongly predictive of good outcome in early diffuse scleroderma: results from an analysis of two randomized controlled trials in early diffuse scleroderma. (14679295)	Sultan N.... Clements P.J.	2004
8	Bilateral breast cancer associated with diffuse scleroderma. (14659331)	Pineda V.... Soriano J.	2003
9	Diffuse scleroderma occurring after the use of paclitaxel for ovarian cancer. (12605319)	De Angelis R.... Filosa G.	2003
10	Methotrexate for the treatment of early diffuse scleroderma: comment on the article by Pope et al. (11920427)	Lehman T.J.	2002
11	Unusual overlap of systemic lupus erythematosus and diffuse scleroderma. (11247318)	Mok C.C.... Szeto M.L.	2001
12	Pseudohypertension in a patient with diffuse scleroderma. (11273902)	Rosner M.H.... Okusa M.D.	2001
13	Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma. (10943881)	Flavahan N.A.... Wigley F.M.	2000
14	Severe organ involvement in systemic sclerosis with diffuse scleroderma. (11083266)	Steen V.D.... Medsger T.A.	2000
15	Minocycline in early diffuse scleroderma. (9848358)	Le C.H.... Trentham D.E.	1998
16	Prevalence of pulmonary hypertension in limited and diffuse scleroderma. (8989070)	Battle R.W.... Tischler M.D.	1996
17	Thrombotic thrombocytopenic purpura in a patient with diffuse scleroderma. (9251403)	Badesha P.S.... Bhardwaj A.	1996
18	Seizures in a patient with diffuse scleroderma. (7494776)	Bhardwaj A.... Badesha P.S.	1995
19	Ketotifen-induced remission in progressive early diffuse scleroderma: evidence for the role of mast cells in disease pathogenesis. (2393046)	Gruber B.L.... Kaufman L.D.	1990
20	Clinical association of autoantibodies to fibrillarin with diffuse scleroderma and disseminated telangiectasia. (2254467)	Kurzhals G.... Reimer G.	1990
21	Progressive systemic sclerosis (diffuse scleroderma) and radiotherapy. (2242481)	Cooper S.G.... Denham J.W.	1990
22	Organ manifestations in 100 patients with progressive systemic sclerosis: a comparison between the CREST syndrome and diffuse scleroderma. (2787182)	Akesson A.... Wollheim F.A.	1989
23	Mast cell numbers in diffuse scleroderma. (3813593)	Nishioka K.... Takijiri C.	1987
24	Scl-86, a marker antigen for diffuse scleroderma. (3980727)	Van Venrooij W.J.... van de Putte L.B.	1985
25	Landmark article May 23, 1942: Diffuse collagen disease. Acute disseminated lupus erythematosus and diffuse scleroderma. By Paul Klemperer, Abou D. Pollack and George Baehr. (6366270)	Klemperer P.... Baehr G.	1984
26	Myocardial function and perfusion in the CREST syndrome variant of progressive systemic sclerosis. Exercise radionuclide evaluation and comparison with diffuse scleroderma. (6475990)	Follansbee W.P.... RODNAN G.P.	1984
27	Pulmonary function in progressive systemic sclerosis. Comparison of CREST syndrome variant with diffuse scleroderma. (6628005)	Owens G.R.... Rogers R.M.	1983
28	Reversible acute renal faiure in diffuse scleroderma. (7408249)	Ponticelli C.... Rossi E.	1980
29	Progressive systemic sclerosis (diffuse scleroderma). A follow-up report of treatment with potaba. (4576830)	Silber W.... Gitlin N.	1973
30	Esophageal reconstruction for stenosis due to diffuse scleroderma. Utilizing blunt dissection of esophagus. (4783042)	Akiyama H.... Itai Y.	1973
31	Recurrent spontaneous pneumothorax in diffuse scleroderma. Report of a case. (5907810)	Edwards W.G.... Dines D.E.	1966
32	Electron microscopic observations on skeletal muscle in diffuse scleroderma. (5944482)	Michalowski R.... Kudejko J.	1966
33	PROGRESSIVE SYSTEMIC SCLEROSIS (DIFFUSE SCLERODERMA) TREATMENT WITH POTABA--A PRELIMINARY REPORT. (14297920)	Silber W.... Gitlin N.	1965
34	THE NERVE NETWORK OF THE SKIN IN DIFFUSE SCLERODERMA AND CLINICALLY SIMILAR CONDITIONS. (14071463)	PAWLOWSKI A.	1963
35	A REVIEW OF RECENT OBSERVATIONS AND CURRENT THEORIES ON THE ETIOLOGY AND PATHOGENESIS OF PROGRESSIVE SYSTEMIC SCLEROSIS (DIFFUSE SCLERODERMA). (14058399)	RODNAN G.P.	1963
36	The natural history of progressive systemic sclerosis (diffuse scleroderma). (13974644)	RODNAN G.P.	1963
37	Immunoelectrophoresis of serum in progressive systemic sclerosis (diffuse scleroderma). (13788679)	Zlotnick A.... RODNAN G.P.	1961
38	Acrosclerosis: a disease sui generis or a variety of diffuse scleroderma. (13638459)	Jablonska S.... Lukasiak B.	1959
39	Esophageal involvement in diffuse scleroderma. (13645796)	DONOGHUE F.E.	1959
40	Diffuse scleroderma; a clinical study of sixty-five cases. (13585869)	STAVA Z.	1958
41	Musculoskeletal manifestations of systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis and diffuse scleroderma. (13539595)	MIKKELSEN W.M.... DUFF I.F.	1958
42	Dental characteristics associated with acrosclerosis and diffuse scleroderma. (13428493)	GORES R.J.	1957
43	Progressive systemic sclerosis; diffuse scleroderma. (13416610)	SINHA G.B.	1957
44	Observations on the use of prednisone in patients with progressive systemic sclerosis (diffuse scleroderma). (13275847)	RODNAN G.P.... BUNIM J.J.	1956
45	Diffuse scleroderma in an African male. (13097594)	GELFAND M.	1953
46	Clinical study of visceral lesions and endocrine disturbances in eight cases of diffuse scleroderma. (14830069)	GIL J.R.	1951
47	Diffuse scleroderma, with report of a case showing multiple lesions. (14852204)	DUFFY D.G.... BARDSLEY A.	1951
48	Esophageal lesions in diffuse scleroderma. (18113050)	Lindsay J.R.	1949
49	Clinical study of visceral lesions and endocrine disturbances in eight cases with diffuse scleroderma. (18100851)	ROBLES GIL J.	1948
50	Diffuse scleroderma with involvement of the heart; report of a case. (20286355)	MATHISEN A.K.... PALMER J.D.	1947

Genes related to Diffuse Scleroderma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals, ⁴⁸Orphanet
See all sources

Genes related to Diffuse Scleroderma:

- Elite gene

id	Symbol	Description	Score	Implication
1	CTGF	connective tissue growth factor	20.00	Susceptibility factor ⁴⁸
2	CAV1	caveolin 1, caveolae protein, 22kDa	17.78	Susceptibility factor ⁴⁸
3	CCR6	chemokine (C-C motif) receptor 6	15.56	Susceptibility factor ⁴⁸
4	IRF5	interferon regulatory factor 5	13.33	Susceptibility factor ⁴⁸
5	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.11	Susceptibility factor ⁴⁸
6	KNG1	kininogen 1	9.95	GeneCards inferred via : Publications (show sections)
7	TGFB1	transforming growth factor, beta 1	7.73	GeneCards inferred via : Publications (show sections)
8	FBL	fibrillarin	5.51	GeneCards inferred via : Publications (show sections)
9	BMP6	bone morphogenetic protein 6	3.28	GeneCards inferred via : Publications (show sections)

Products for genes related to Diffuse Scleroderma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	9	-	9	9
2	Novus Biologicals	7	9	9	-

Variations for Diffuse Scleroderma

Expression for genes affiliated with Diffuse Scleroderma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Diffuse Scleroderma

Search GEO for disease gene expression data for Diffuse Scleroderma.

Pathways for genes affiliated with Diffuse Scleroderma

Sources:
⁴⁹PathCards, ³⁷NCBI BioSystems Database, ⁵⁹Thomson Reuters, ⁵⁰PharmGKB, ³⁰KEGG, ⁵²QIAGEN
See all sources

Pathways related to Diffuse Scleroderma according to GeneCards/GeneDecks:

(show all 19)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	amb2 Integrin signaling³⁷	9.6	CTGF, KNG1
2	Development TGF beta receptor signaling⁵⁹	9.5	CAV1, TGFB1
3	ALK1 signaling events³⁷ Show member pathways ALK1 pathway³⁷	9.5	CAV1, TGFB1
4	IL12 signaling mediated by STAT4³⁷	9.4	TGFB1, HLA-DRB1
5	Cytokines and Inflammatory Response³⁷	9.4	TGFB1, HLA-DRB1
6	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics⁵⁰ Show member pathways ACE Inhibitor Pathway, Pharmacodynamics⁵⁰ Renin-angiotensin system³⁰ ACE Inhibitor Pathway³⁷	9.3	TGFB1, KNG1
7	Syndecan-2-mediated signaling events³⁷	9.3	KNG1, TGFB1
8	Endochondral Ossification³⁷	9.3	TGFB1, BMP6
9	TGF-beta receptor signaling³⁷	9.2	CTGF, CAV1, TGFB1
10	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	9.1	CAV1, TGFB1, HLA-DRB1
11	NF-KappaB Family Pathway⁵² Show member pathways NF-KappaB (p50-p65) Pathway⁵²	9.0	TGFB1, BMP6, CTGF
12	Hippo signaling pathway³⁰	9.0	TGFB1, BMP6, CTGF
13	Phospholipase-C Pathway⁵² Show member pathways PTEN Pathway⁵²	9.0	CTGF, BMP6, TGFB1
14	p70S6K Signaling⁵² Show member pathways Renin-Angiotensin Pathway⁵² mTOR Pathway⁵²	9.0	CTGF, BMP6, TGFB1
15	Nanog in Mammalian ESC Pluripotency⁵² Show member pathways GSK3 Signaling⁵² eNOS Signaling⁵² 14-3-3 Induced Intracellular Signaling⁵²	8.7	CTGF, CAV1, BMP6, TGFB1
16	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.6	TGFB1, CCR6, BMP6, CTGF
17	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.6	TGFB1, CCR6, BMP6, CTGF
18	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	8.6	TGFB1, CCR6, BMP6, CTGF
19	GPCR Pathway⁵² Show member pathways Breast Cancer Regulation by Stathmin1⁵² Pancreatic Adenocarcinoma⁵² P2Y Receptor Signaling⁵² Ras Pathway⁵² Paxillin Interactions⁵² NFAT in Immune Response⁵² Estrogen Pathway⁵²	8.6	HLA-DRB1, TGFB1, BMP6, CTGF

Compounds for genes affiliated with Diffuse Scleroderma

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ³BitterDB, ¹²DrugBank, ⁶⁰Tocris Bioscience, ⁵⁰PharmGKB, ²⁵HMDB
See all sources

Compounds related to Diffuse Scleroderma according to GeneCards/GeneDecks:

(show top 50) (show all 71)

id	Compound	Score	Top Affiliating Genes
1	des-arg(10)-kallidin⁴⁴	10.1	CTGF, KNG1
2	kallidin⁴⁴ ²⁹	11.0	KNG1, CTGF
3	aristolochic acid⁴⁴ ³	10.9	CTGF, TGFB1
4	tranilast⁴⁴	9.7	TGFB1, BMP6
5	ramipril⁴⁴ ¹²	10.7	KNG1, TGFB1
6	pirfenidone⁴⁴ ⁶⁰	10.7	BMP6, TGFB1
7	simvastatin⁴⁴ ⁵⁰ ⁶⁰ ²⁹ ²⁵ ¹²	14.7	CTGF, CAV1, BMP6
8	5-aza-2deoxycytidine⁴⁴	9.7	CAV1, BMP6, CTGF
9	perindopril⁴⁴ ⁵⁰ ¹²	11.7	TGFB1, KNG1
10	vitamin e succinate⁴⁴	9.6	BMP6, TGFB1
11	pmma⁴⁴	9.6	TGFB1, BMP6
12	agar⁴⁴	9.6	BMP6, CAV1, CTGF
13	cytochalasin d⁴⁴ ⁶⁰	10.6	TGFB1, CAV1, CTGF
14	hmba⁴⁴	9.5	BMP6, TGFB1
15	carbachol⁴⁴ ²⁹ ¹²	11.5	KNG1, CAV1, BMP6
16	ang ii⁴⁴	9.4	TGFB1, CTGF, KNG1
17	hydroxyproline⁴⁴ ²⁵ ¹²	11.4	BMP6, TGFB1, CTGF
18	enalapril⁴⁴ ⁵⁰ ¹²	11.4	KNG1, BMP6
19	procollagen⁴⁴	9.4	TGFB1, BMP6, CTGF
20	tgf beta1⁴⁴	9.4	CTGF, BMP6, TGFB1
21	verapamil⁴⁴ ²⁹ ⁵⁰ ²⁵ ¹²	13.4	KNG1, CAV1, TGFB1
22	candesartan⁴⁴ ⁵⁰ ²⁹ ¹²	12.3	KNG1, TGFB1
23	rantes⁴⁴	9.2	CCR6, BMP6, TGFB1
24	sodium nitroprusside⁴⁴	9.2	BMP6, KNG1, TGFB1
25	prostacyclin⁴⁴	9.2	BMP6, KNG1, CTGF, CAV1
26	methotrexate⁵⁰ ⁴⁴ ¹²	11.2	HLA-DRB1, TGFB1, BMP6
27	matrigel⁴⁴	9.2	CAV1, BMP6, TGFB1
28	heparin⁴⁴ ²⁹ ²⁵ ¹²	12.2	CTGF, BMP6, CAV1, KNG1
29	aspirin⁴⁴ ⁵⁰ ²⁹ ²⁵	12.1	TGFB1, KNG1, BMP6
30	ribonucleic acid⁴⁴	9.1	CTGF, BMP6, TGFB1
31	bleomycin⁴⁴ ¹²	10.1	BMP6, TGFB1, CTGF, CAV1
32	ly294002⁴⁴	9.1	BMP6, CTGF, CAV1, TGFB1
33	cyclosporin a⁴⁴ ²⁹ ⁶⁰	11.1	TGFB1, BMP6, CAV1, CTGF
34	phosphatidylinositol⁴⁴	9.0	CAV1, KNG1, CTGF, BMP6
35	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	12.0	CAV1, CTGF, TGFB1, BMP6
36	nitric oxide⁴⁴ ²⁵ ¹²	11.0	KNG1, CTGF, CAV1, BMP6
37	losartan⁴⁴ ⁵⁰ ²⁹ ¹²	11.9	TGFB1, KNG1, BMP6, CTGF
38	nifedipine⁴⁴ ²⁹ ⁵⁰ ¹²	11.9	CTGF, KNG1, TGFB1, BMP6
39	sb 203580⁴⁴ ⁶⁰	9.9	BMP6, CTGF, TGFB1
40	pge2⁴⁴	8.9	TGFB1, KNG1, BMP6, CTGF
41	threonine⁴⁴	8.9	TGFB1, CAV1, CTGF, BMP6
42	indomethacin⁴⁴ ²⁹ ⁶⁰ ¹²	11.9	KNG1, TGFB1, BMP6
43	tamoxifen⁴⁴ ⁵⁰ ²⁹ ¹²	11.7	CAV1, BMP6, TGFB1
44	alanine⁴⁴	8.7	HLA-DRB1, CAV1, TGFB1, BMP6
45	oligonucleotide⁴⁴	8.6	CAV1, HLA-DRB1, CTGF, TGFB1, BMP6
46	arginine⁴⁴	8.6	KNG1, FBL, HLA-DRB1, CAV1
47	cycloheximide⁴⁴	8.6	CAV1, BMP6, KNG1, CTGF, TGFB1
48	vegf⁴⁴	8.3	TGFB1, IRF5, BMP6, CAV1, CTGF, CCR6
49	tyrosine⁴⁴	8.3	IRF5, CAV1, BMP6, KNG1, CTGF, HLA-DRB1
50	serine⁴⁴	7.8	FBL, TGFB1, CAV1, KNG1, CTGF, BMP6

GO Terms for genes affiliated with Diffuse Scleroderma

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Diffuse Scleroderma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle membrane	GO:030666	9.7	CAV1, HLA-DRB1
2	platelet alpha granule lumen	GO:031093	9.0	KNG1, TGFB1
3	plasma membrane	GO:005886	7.7	CTGF, HLA-DRB1, TGFB1, CCR6, CAV1, KNG1

Biological processes related to Diffuse Scleroderma according to GeneCards/GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of collagen biosynthetic process	GO:032967	9.8	CTGF, TGFB1
2	response to progesterone	GO:032570	9.8	TGFB1, CAV1
3	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.7	CAV1, TGFB1
4	response to wounding	GO:009611	9.7	CTGF, TGFB1
5	negative regulation of T cell proliferation	GO:042130	9.7	TGFB1, HLA-DRB1
6	positive regulation of protein secretion	GO:050714	9.6	BMP6, TGFB1
7	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.6	TGFB1, BMP6
8	interferon-gamma-mediated signaling pathway	GO:060333	9.6	HLA-DRB1, IRF5
9	response to glucose	GO:009749	9.6	CTGF, TGFB1
10	positive regulation of bone mineralization	GO:030501	9.6	TGFB1, BMP6
11	T cell costimulation	GO:031295	9.6	CAV1, HLA-DRB1
12	positive regulation of epithelial cell proliferation	GO:050679	9.4	TGFB1, BMP6
13	immune response	GO:006955	9.3	HLA-DRB1, CCR6, BMP6
14	MAPK cascade	GO:000165	9.2	CAV1, TGFB1
15	positive regulation of apoptotic process	GO:043065	9.2	KNG1, IRF5, TGFB1
16	inflammatory response	GO:006954	9.0	KNG1, BMP6, TGFB1
17	blood coagulation	GO:007596	9.0	KNG1, CAV1, TGFB1