Diffuse Scleroderma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Diffuse Scleroderma

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³²MalaCards
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MalaCards: Diffuse Scleroderma, also known as diffuse cutaneous systemic scleroderma, is related to systemic scleroderma and systemic lupus erythematosus, and has symptoms including dyspareunia/coital pain/vaginal dryness, autoimmunity/autoimmune reaction/autoantibodies and periarticular tissue anomaly/extraarticular calcifications. An important gene associated with Diffuse Scleroderma is HLA-DRB1 (major histocompatibility complex, class II, DR beta 1), and among its related pathways are Cytokines and Inflammatory Response and IL12 signaling mediated by STAT4. The compounds cyclosporin a and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Diffuse Scleroderma

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ⁶⁰UMLS, ⁴⁸Orphanet, ⁵⁶SNOMED-CT, ³⁴MeSH, ⁵⁷SNOMED-CT via Orphanet, ²⁶ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Respiratory diseases, Bone diseases, Skin diseases

ICD10: ²⁶

Diseases of the musculoskeletal system and connective tissue

Systemic connective tissue disorders

Systemic sclerosis

Progressive systemic sclerosis

Characteristics (Orphanet epidemiological data):

⁴⁸

diffuse cutaneous systemic scleroderma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult

Aliases & Descriptions:

diffuse scleroderma ⁸ ⁴² ⁶⁰

diffuse cutaneous systemic scleroderma ⁴² ⁴⁸

diffuse cutaneous systemic sclerosis ⁴² ⁴⁸

diffuse systemic sclerosis ⁸ ⁴²

progressive cutaneous systemic scleroderma ⁴⁸

progressive cutaneous systemic sclerosis ⁴⁸

systemic sclerosis, diffuse ⁸

sudden onset scleroderma ⁴²

dcssc ⁴²

External Ids:

Disease Ontology⁸ DOID:1580

MeSH³⁴ D045743, C536175

SNOMED-CT⁵⁶ 128460000, 444133002

SNOMED-CT via Orphanet⁵⁷ 128460000

ICD10 via Orphanet²⁶ M34.0

UMLS⁶⁰ C1258104

Related Diseases for Diffuse Scleroderma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Diffuse Scleroderma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 105)

id	Related Disease	Score	Top Affiliating Genes
1	systemic scleroderma	31.0	CTGF, IRF5
2	systemic lupus erythematosus	30.2	IRF5
3	interstitial lung disease	30.2	BMP6, TGFB1
4	hepatitis	30.0	CAV1
5	connective tissue disease	30.0	BMP6, CTGF, FBL
6	pulmonary fibrosis	30.0	FBL, CTGF, BMP6, TGFB1, CAV1
7	dermatomyositis	30.0	FBL
8	skin disease	29.9	HLA-DRB1, TGFB1
9	hypertension	29.9	TGFB1, KNG1, CAV1
10	arthritis	29.9	CTGF, TGFB1, KNG1, HLA-DRB1
11	rheumatoid arthritis	29.9	HLA-DRB1, BMP6, CCR6, CTGF, IRF5
12	scleroderma	10.9
13	lupus erythematosus	10.3
14	esophagitis	10.2
15	limited scleroderma	10.1
16	pulmonary systemic sclerosis	10.1
17	mixed connective tissue disease	10.0
18	diffuse pulmonary fibrosis	10.0
19	gastric antral vascular ectasia	10.0
20	steatorrhea	10.0
21	actinomycosis	10.0
22	autoimmune hepatitis	10.0
23	hepatitis a	10.0
24	crohn's disease	10.0
25	subcorneal pustular dermatosis	10.0
26	polyarteritis nodosa	10.0
27	thrombotic thrombocytopenic purpura	10.0
28	aplastic anemia	10.0
29	bilateral breast cancer	10.0
30	breast cancer	10.0
31	collagen disease	10.0
32	kidney disease	10.0
33	ovarian cancer	10.0
34	pneumothorax	10.0
35	purpura	10.0
36	squamous cell carcinoma	10.0
37	reynolds syndrome	10.0
38	marfan syndrome	10.0	BMP6
39	inflammatory bowel disease	10.0	TGFB1
40	thyroiditis	10.0	HLA-DRB1
41	pulmonary disease, chronic obstructive	10.0	TGFB1
42	essential hypertension	10.0	KNG1
43	lupus nephritis	10.0	TGFB1
44	urticaria	10.0	KNG1
45	diabetic retinopathy	10.0	CTGF
46	hemochromatosis	10.0	BMP6
47	nephritis	10.0	CTGF
48	insulin resistance	10.0	CTGF
49	myositis	10.0	FBL
50	glaucoma	10.0	CTGF

Graphical network of the top 20 diseases related to Diffuse Scleroderma:

Clinical Features for Diffuse Scleroderma

Sources:
⁴⁸Orphanet
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Symptoms:

⁴⁸ (show all 31)

dyspareunia/coital pain/vaginal dryness
autoimmunity/autoimmune reaction/autoantibodies
periarticular tissue anomaly/extraarticular calcifications
tendon rupture/tendinitis/bursitis/tenosynovitis
lung/pulmonary infiltrates
pulmonary hypertension
osteolysis/osteoclasia/bone destruction/erosions
intestinal transit disorder
acute arterial hypertension/hypertensive crisis
radiologic lung abnormalities/changes
mouth dryness/xerostomia
heart/cardiac failure
telangiectasiae of the skin
feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
respiratory distress/dyspnea/respiratory failure/lung volume reduction

muscle weakness/flaccidity
dermal/subcutaneous infiltration/induration
anomalies of skin, subcutaneous tissue and mucosae
arthritis/synovitis/synovial proliferation
multiple caries
malabsorption/chronic diarrhea/steatorrhea
gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
contractures/cramps/trismus/tetania/claudication/opisthotonos
renal failure
articular/joint pain/arthralgia
lung fibrosis
acrocyanosis/raynaud's phenomenon/vasomotor disorders
dry/squaly skin/exfoliation
chronic skin infection/ulcerations/ulcers/cancrum
nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Diffuse Scleroderma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Diffuse Scleroderma

Drug clinical trials:

Search ClinicalTrials for Diffuse Scleroderma

Search NIH Clinical Center for Diffuse Scleroderma

Search CenterWatch for Diffuse Scleroderma

Genetic Tests for Diffuse Scleroderma

Anatomical Context for Diffuse Scleroderma

Sources:
³²MalaCards
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MalaCards organs/tissues related to Diffuse Scleroderma:

³²

Skin, Lung, Bone, Heart, Small intestine, Kidney, Skeletal muscle, Breast

Animal Models for Diffuse Scleroderma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Diffuse Scleroderma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	7.2	TGFB1, KNG1, ARPC2, CTGF, IRF5, CAV1

Publications for Diffuse Scleroderma

Sources:
⁵⁰PubMed
See all sources

Articles related to Diffuse Scleroderma:

(show top 50) (show all 95)

id	Title	Authors	Year
1	Evidence-based management of hand and mouth disability in a woman living with diffuse systemic sclerosis (scleroderma). (24396157)	Poole J.L.... Deboer H.N.	2013
2	Subcutaneous calcifications in a patient with diffuse scleroderma. (23910621)	Markatseli T.E.... Voulgari P.V.	2013
3	Successful treatment of steroid and cyclophosphamide-resistant diffuse scleroderma-associated interstitial lung disease with rituximab. (20058013)	Yoo W.H.	2012
4	Patterns and predictors of change in outcome measures in clinical trials in scleroderma: an individual patient meta-analysis of 629 subjects with diffuse cutaneous systemic sclerosis. (22328195)	Merkel P.A.... Seibold J.R.	2012
5	MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma. (22307526)	Zhu H.... Zuo X.	2012
6	Skin thickness progression rate: a predictor of mortality and early internal organ involvement in diffuse scleroderma. (20679474)	Domsic R.T.... Medsger T.A.	2011
7	Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients. (21615510)	Arakawa H.... Ihn H.	2011
8	Hearing loss in diffuse cutaneous systemic scleroderma. (21916804)	Monteiro T.A.... Vasconcelos L.G.	2011
9	A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity. (19812599)	Sargent J.L.... Whitfield M.L.	2010
10	Squamous cell carcinomas in 2 patients with diffuse scleroderma treated with mycophenolate mofetil. (19208586)	Gulamhusein A.... Pope J.E.	2009
11	Subcorneal pustular dermatosis in a patient with rheumatoid arthritis and diffuse scleroderma. (19379649)	Brantley E.I.... Sheth P.	2009
12	Autologous stem cell transplantation in diffuse scleroderma: impact on hand structure and function. (18336540)	Englert H.... Manolios N.	2008
13	Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. (16871530)	Chan E.S.... Cronstein B.N.	2006
14	Kidney disease other than renal crisis in patients with diffuse scleroderma. (15801020)	Steen V.D.... Medsger T.A.	2005
15	The health assessment questionnaire (HAQ) is strongly predictive of good outcome in early diffuse scleroderma: results from an analysis of two randomized controlled trials in early diffuse scleroderma. (14679295)	Sultan N.... Clements P.J.	2004
16	Methotrexate for the treatment of early diffuse scleroderma: comment on the article by Pope et al. (11920427)	Lehman T.J.	2002
17	Unusual overlap of systemic lupus erythematosus and diffuse scleroderma. (11247318)	Mok C.C.... Szeto M.L.	2001
18	Minocycline in early diffuse scleroderma. (9848358)	Le C.H.... Trentham D.E.	1998
19	Thrombotic thrombocytopenic purpura in a patient with diffuse scleroderma. (9251403)	Badesha P.S.... Bhardwaj A.	1996
20	Interstitial Lung Disease Developing during Treatment with Cyclosporine in a patient with Diffuse Scleroderma, Aplastic Anemia and Crohn's Disease: Implications for Pathogenesis and Treatment. (19077999)	Davies J.M.... Dunn H.G.	1995
21	Autonomic dysfunction in diffuse scleroderma vs CREST: an assessment by computerized heart rate variability. (7837149)	Hermosillo A.G.... MartA-nez-LavA-n M.	1994
22	Clinical association of autoantibodies to fibrillarin with diffuse scleroderma and disseminated telangiectasia. (2254467)	Kurzhals G.... Reimer G.	1990
23	Progressive systemic sclerosis (diffuse scleroderma) and radiotherapy. (2242481)	Cooper S.G.... Denham J.W.	1990
24	Elevated serum levels of soluble interleukin 2 receptor, interleukin 2 and neopterin in diffuse and limited scleroderma: effects of chlorambucil. (2213757)	Clements P.J.... Furst D.E.	1990
25	Landmark article May 23, 1942: Diffuse collagen disease. Acute disseminated lupus erythematosus and diffuse scleroderma. By Paul Klemperer, Abou D. Pollack and George Baehr. (6366270)	Klemperer P.... Baehr G.	1984
26	Myocardial function and perfusion in the CREST syndrome variant of progressive systemic sclerosis. Exercise radionuclide evaluation and comparison with diffuse scleroderma. (6475990)	Follansbee W.P.... RODNAN G.P.	1984
27	Pulmonary function in progressive systemic sclerosis. Comparison of CREST syndrome variant with diffuse scleroderma. (6628005)	Owens G.R.... Rogers R.M.	1983
28	Acute diffuse scleroderma. (6165202)	Nunzi E.... Cormane R.H.	1981
29	Diffuse eosinophilic fasciitis. A new syndrome or variant of Scleroderma? (931403)	Torres V.M.... GEORGE W.M.	1977
30	Progressive systemic sclerosis (diffuse scleroderma). A follow-up report of treatment with potaba. (4576830)	Silber W.... Gitlin N.	1973
31	Epidemiology of fatal systemic sclerosis (diffuse scleroderma). A 15-year survey in Baltimore. (6025228)	Masi A.T.... D'Angelo W.A.	1967
32	PROGRESSIVE SYSTEMIC SCLEROSIS (DIFFUSE SCLERODERMA) TREATMENT WITH POTABA--A PRELIMINARY REPORT. (14297920)	Silber W.... Gitlin N.	1965
33	AN EARLY PULMONARY PHYSIOLOGIC ABNORMALITY IN PROGRESSIVE SYSTEMIC SCLEROSIS (DIFFUSE SCLERODERMA). (14131880)	Wilson R.J.... Robin E.D.	1964
34	THE NERVE NETWORK OF THE SKIN IN DIFFUSE SCLERODERMA AND CLINICALLY SIMILAR CONDITIONS. (14071463)	PAWLOWSKI A.	1963
35	The natural history of progressive systemic sclerosis (diffuse scleroderma). (13974644)	RODNAN G.P.	1963
36	Diffuse systemic scleroderma. A comparison with acrosclerosis. (13923026)	Tuffanelli D.L.... Winkelmann R.K.	1962
37	Arrested diffuse scleroderma. Report of a case. (13935465)	MICHANOWICZ A.E.	1962
38	Diffuse scleroderma and Raynaud's disease. (14450537)	Jablonska S.... Szczepanski A.	1962
39	Diffuse scleroderma. (14461917)	LANCELEY J.L.	1962
40	Roentgen manifestations in progressive systemic sclerosis (diffuse scleroderma). (13850944)	Gondos B.	1960
41	Acrosclerosis: a disease sui generis or a variety of diffuse scleroderma. (13638459)	Jablonska S.... Lukasiak B.	1959
42	Esophageal involvement in diffuse scleroderma. (13645796)	DONOGHUE F.E.	1959
43	Diffuse scleroderma; a clinical study of sixty-five cases. (13585869)	STAVA Z.	1958
44	Musculoskeletal manifestations of systemic lupus erythematosus, polyarteritis nodosa, dermatomyositis and diffuse scleroderma. (13539595)	MIKKELSEN W.M.... DUFF I.F.	1958
45	Progressive systemic sclerosis; diffuse scleroderma. (13416610)	SINHA G.B.	1957
46	Observations on the use of prednisone in patients with progressive systemic sclerosis (diffuse scleroderma). (13275847)	RODNAN G.P.... BUNIM J.J.	1956
47	Diffuse scleroderma, with report of a case showing multiple lesions. (14852204)	DUFFY D.G.... BARDSLEY A.	1951
48	Esophageal lesions in diffuse scleroderma. (18113050)	Lindsay J.R.	1949
49	Clinical study of visceral lesions and endocrine disturbances in eight cases with diffuse scleroderma. (18100851)	ROBLES GIL J.	1948
50	Diffuse scleroderma with involvement of the heart; report of a case. (20286355)	MATHISEN A.K.... PALMER J.D.	1947

Genes related to Diffuse Scleroderma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc., ⁴⁸Orphanet
See all sources

Genes related to Diffuse Scleroderma:

id	Symbol	Description	Score	Implication
1	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	20.95	Susceptibility factor ⁴⁸ GeneCards inferred : Disorders (show sections)
2	CTGF	connective tissue growth factor	18.00	Susceptibility factor ⁴⁸
3	IRF5	interferon regulatory factor 5	16.00	Susceptibility factor ⁴⁸
4	CAV1	caveolin 1, caveolae protein, 22kDa	14.00	Susceptibility factor ⁴⁸
5	CCR6	chemokine (C-C motif) receptor 6	12.00	Susceptibility factor ⁴⁸
6	KNG1	kininogen 1	10.95	GeneCards inferred : Publications, Disorders (show sections)
7	TGFB1	transforming growth factor, beta 1	8.95	GeneCards inferred : Publications, Disorders (show sections)
8	FBL	fibrillarin	6.95	GeneCards inferred : Publications, Disorders (show sections)
9	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	4.95	GeneCards inferred : Disorders (show sections)
10	BMP6	bone morphogenetic protein 6	2.95	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Diffuse Scleroderma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	10	10	10
2	LSBio	-	-	10

Genetic Variations for Diffuse Scleroderma

Expression for genes affiliated with Diffuse Scleroderma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Diffuse Scleroderma

Search GEO for disease gene expression data for Diffuse Scleroderma.

Pathways for genes affiliated with Diffuse Scleroderma

Sources:
³⁷NCBI BioSystems Database, ²⁹KEGG, ⁴⁹PharmGKB, ⁵¹QIAGEN
See all sources

Pathways related to Diffuse Scleroderma according to GeneCards/GeneDecks:

(show all 12)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Cytokines and Inflammatory Response³⁷	9.7	HLA-DRB1, TGFB1
2	IL12 signaling mediated by STAT4³⁷	9.7	HLA-DRB1, TGFB1
3	Hippo signaling pathway²⁹	9.6	CTGF, TGFB1
4	ALK1 signaling events³⁷	9.6	TGFB1, CAV1
5	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics⁴⁹ Hide members ACE Inhibitor Pathway, Pharmacodynamics⁴⁹ ACE Inhibitor Pathway³⁷	9.5	TGFB1, KNG1
6	Syndecan-2-mediated signaling events³⁷	9.5	TGFB1, KNG1
7	TGF-beta receptor signaling³⁷	9.3	TGFB1, CTGF, CAV1
8	NF-KappaB Family Pathway⁵¹ Hide members NF-KappaB (p50-p65) Pathway⁵¹	9.1	TGFB1, BMP6, CTGF
9	GPCR Pathway⁵¹ Hide members Pancreatic Adenocarcinoma⁵¹ Ras Pathway⁵¹ Paxillin Interactions⁵¹ Breast Cancer Regulation by Stathmin1⁵¹ NFAT in Immune Response⁵¹ Estrogen Pathway⁵¹	8.8	CTGF, BMP6, HLA-DRB1, TGFB1
10	Nanog in Mammalian ESC Pluripotency⁵¹ Hide members GSK3 Signaling⁵¹ eNOS Signaling⁵¹ 14-3-3 Induced Intracellular Signaling⁵¹	8.7	TGFB1, BMP6, CTGF, CAV1
11	Akt Signaling⁵¹ Hide members p38 Signaling⁵¹ Tec Kinases Signaling⁵¹	8.7	CCR6, CTGF, BMP6, TGFB1
12	PAK Pathway⁵¹ Hide members Epithelial Adherens Junctions⁵¹ Antioxidant Action of Vitamin-C⁵¹	8.7	CCR6, CTGF, BMP6, TGFB1

Compounds for genes affiliated with Diffuse Scleroderma

Sources:
⁴⁴Novoseek, ²⁸IUPHAR, ⁵⁹Tocris Bioscience, ²BitterDB, ¹¹DrugBank, ⁴⁹PharmGKB, ²⁴HMDB
See all sources

Compounds related to Diffuse Scleroderma according to GeneCards/GeneDecks:

(show all 41)

id	Compound	Score	Top Affiliating Genes
1	cyclosporin a⁴⁴ ²⁸ ⁵⁹	12.5	CTGF
2	cycloheximide⁴⁴	10.5	CAV1
3	procollagen⁴⁴	10.4	TGFB1
4	pge2⁴⁴	10.3	TGFB1
5	des-arg(10)-kallidin⁴⁴	10.1	KNG1, CTGF
6	kallidin⁴⁴ ²⁸	11.1	KNG1, CTGF
7	aristolochic acid⁴⁴ ²	10.9	CTGF, TGFB1
8	tranilast⁴⁴	9.8	TGFB1, BMP6
9	ramipril⁴⁴ ¹¹	10.8	TGFB1, KNG1
10	perindopril⁴⁴ ⁴⁹ ¹¹	11.8	TGFB1, KNG1
11	pirfenidone⁴⁴ ⁵⁹	10.7	BMP6, TGFB1
12	vitamin e succinate⁴⁴	9.7	BMP6, TGFB1
13	pmma⁴⁴	9.7	TGFB1, BMP6
14	candesartan⁴⁴ ²⁸ ¹¹	11.6	TGFB1, KNG1
15	cytochalasin d⁴⁴ ⁵⁹	10.6	TGFB1, CTGF, CAV1
16	ang ii⁴⁴	9.6	TGFB1, KNG1, CTGF
17	simvastatin⁴⁴ ⁴⁹ ⁵⁹ ²⁸ ¹¹ ²⁴	14.6	BMP6, CTGF, CAV1
18	enalapril⁴⁴ ⁴⁹ ¹¹	11.6	BMP6, KNG1
19	5-aza-2deoxycytidine⁴⁴	9.5	BMP6, CTGF, CAV1
20	hydroxyproline⁴⁴ ¹¹ ²⁴	11.5	CTGF, BMP6, TGFB1
21	verapamil⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	13.5	TGFB1, KNG1, CAV1
22	carbachol⁴⁴ ²⁸ ¹¹	11.5	CAV1, BMP6, KNG1
23	tgf beta1⁴⁴	9.4	TGFB1, BMP6, CTGF
24	agar⁴⁴	9.4	BMP6, CTGF, CAV1
25	sodium nitroprusside⁴⁴	9.3	TGFB1, KNG1, BMP6
26	methotrexate⁴⁴ ⁴⁹ ¹¹	11.3	BMP6, HLA-DRB1, TGFB1
27	prostacyclin⁴⁴	9.2	KNG1, BMP6, CTGF, CAV1
28	aspirin⁴⁴ ⁴⁹ ²⁸ ²⁴	12.2	TGFB1, KNG1, BMP6
29	bleomycin⁴⁴ ¹¹	10.2	CAV1, CTGF, BMP6, TGFB1
30	ly294002⁴⁴	9.1	CAV1, CTGF, BMP6, TGFB1
31	heparin⁴⁴ ²⁸ ¹¹ ²⁴	12.1	CAV1, CTGF, BMP6, KNG1
32	ribonucleic acid⁴⁴	9.1	TGFB1, BMP6, CTGF
33	losartan⁴⁴ ⁴⁹ ²⁸ ¹¹	12.1	TGFB1, KNG1, BMP6, CTGF
34	nifedipine⁴⁴ ⁴⁹ ²⁸ ¹¹	12.1	CTGF, BMP6, KNG1, TGFB1
35	rantes⁴⁴	9.0	TGFB1, BMP6, CCR6
36	oligonucleotide⁴⁴	8.8	TGFB1, HLA-DRB1, BMP6, CTGF, CAV1
37	matrigel⁴⁴	8.8	TGFB1, BMP6, CAV1
38	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	11.6	CAV1, CTGF, BMP6, TGFB1
39	serine⁴⁴	8.6	CAV1, CTGF, FBL, KNG1, TGFB1
40	tyrosine⁴⁴	8.5	IRF5, CTGF, BMP6, HLA-DRB1, KNG1, CAV1
41	vegf⁴⁴	8.4	CCR6, CAV1, IRF5, CTGF, BMP6, TGFB1

GO Terms for genes affiliated with Diffuse Scleroderma

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Diffuse Scleroderma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of collagen biosynthetic process	GO:032967	9.7	TGFB1, CTGF
2	response to progesterone stimulus	GO:032570	9.6	TGFB1, CAV1
3	positive regulation of protein secretion	GO:050714	9.5	TGFB1, BMP6
4	positive regulation of bone mineralization	GO:030501	9.4	TGFB1, BMP6
5	negative regulation of T cell proliferation	GO:042130	9.4	TGFB1, HLA-DRB1
6	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	9.3	BMP6, TGFB1