Digital Clubbing, Isolated Congenital malady
Genetic diseases, Bone diseases, Skin diseases, Fetal diseases, Rare diseases categories
Aliases & Descriptions for Digital Clubbing, Isolated Congenital:
MalaCards categories: See all MalaCards categories (disease lists)
Global: Genetic diseases, Fetal diseases, Rare diseases
Anatomical: Bone diseases, Skin diseases
Characteristics (Orphanet epidemiological data):51
isolated congenital digital clubbing:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Infancy,Neonatal
UniProtKB/Swiss-Prot:67 Isolated congenital nail clubbing: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
MalaCards based summary: Digital Clubbing, Isolated Congenital, is also known as isolated congenital digital clubbing, and has symptoms including autosomal dominant inheritanceand clubbing. An important gene associated with Digital Clubbing, Isolated Congenital is HPGD (Hydroxyprostaglandin Dehydrogenase 15-(NAD)). Affiliated tissues include skin and bone.
OMIM:49 Digital clubbing is characterized by enlargement of the nail plate and terminal segments of the fingers and toes,... (119900) more...
Drugs for Digital Clubbing, Isolated Congenital (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
Interventional clinical trials:
Search NIH Clinical Center for Digital Clubbing, Isolated Congenital
MalaCards organs/tissues related to Digital Clubbing, Isolated Congenital:33
UniProtKB/Swiss-Prot genetic disease variations for Digital Clubbing, Isolated Congenital:67
Clinvar genetic disease variations for Digital Clubbing, Isolated Congenital:5
Search GEO for disease gene expression data for Digital Clubbing, Isolated Congenital.
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet