MCID: DHY011
MIFTS: 16

Dihydropyrimidinase Deficiency malady

Summaries for Dihydropyrimidinase Deficiency

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32MalaCards
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MalaCards: Dihydropyrimidinase Deficiency is related to dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. An important gene associated with Dihydropyrimidinase Deficiency is DPYS (dihydropyrimidinase), and among its related pathways are Purine metabolism and Glucuronidation. The compounds 5,6-dihydrothymine and dihydrouracil have been mentioned in the context of this disorder.

Aliases & Classifications for Dihydropyrimidinase Deficiency

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20GeneTests, 22GTR, 60UMLS
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Aliases & Descriptions:

dihydropyrimidinase deficiency 20 22 60


Related Diseases for Dihydropyrimidinase Deficiency

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dihydropyrimidinase Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1dihydropyrimidine dehydrogenase deficiency30.4DPYD, DPYS
25-fluorouracil toxicity10.0DPYD

Clinical Features for Dihydropyrimidinase Deficiency

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Drugs & Therapeutics for Dihydropyrimidinase Deficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dihydropyrimidinase Deficiency

Drug clinical trials:

Search ClinicalTrials for Dihydropyrimidinase Deficiency

Search NIH Clinical Center for Dihydropyrimidinase Deficiency

Search CenterWatch for Dihydropyrimidinase Deficiency

Genetic Tests for Dihydropyrimidinase Deficiency

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20GeneTests, 22GTR
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Genetic tests related to Dihydropyrimidinase Deficiency:

id Genetic test Affiliating Genes
1 Dihydropyrimidinase Deficiency20 22 DPYS

Anatomical Context for Dihydropyrimidinase Deficiency

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Animal Models for Dihydropyrimidinase Deficiency or affiliated genes

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Publications for Dihydropyrimidinase Deficiency

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Genetic Variations for Dihydropyrimidinase Deficiency

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Expression for genes affiliated with Dihydropyrimidinase Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dihydropyrimidinase Deficiency

Search GEO for disease gene expression data for Dihydropyrimidinase Deficiency.

Pathways for genes affiliated with Dihydropyrimidinase Deficiency

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 12EMD Millipore
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Pathways related to Dihydropyrimidinase Deficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1DPYD, DPYS
2
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9.1DPYD, DPYS
3
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9.1DPYD, DPYS
4
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9.1DPYS, DPYD
59.1DPYD, DPYS
6
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9.1DPYD, DPYS
7
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9.1DPYD, DPYS
89.1DPYD, DPYS

Compounds for genes affiliated with Dihydropyrimidinase Deficiency

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44Novoseek, 24HMDB
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Compounds related to Dihydropyrimidinase Deficiency according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15,6-dihydrothymine449.3DPYD, DPYS
2dihydrouracil44 2410.3DPYD, DPYS
3molybdenum44 2410.3DPYD, DPYS
4purine nucleoside449.2DPYD, DPYS
5thymine44 2410.2DPYS, DPYD
6pyrimidine44 2410.1DPYD, DPYS
7thymidine44 2410.1DPYD, DPYS
8purine44 2410.0DPYD, DPYS
95fluorouracil448.8DPYD, DPYS

GO Terms for genes affiliated with Dihydropyrimidinase Deficiency

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16Gene Ontology
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Biological processes related to Dihydropyrimidinase Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thymine catabolic processGO:0062109.2DPYD, DPYS
2uracil catabolic processGO:0062129.2DPYD, DPYS
3pyrimidine nucleobase catabolic processGO:0062089.1DPYD, DPYS
4nucleobase-containing small molecule metabolic processGO:0550869.1DPYD, DPYS
5pyrimidine nucleoside catabolic processGO:0461359.0DPYS, DPYD
6pyrimidine nucleobase metabolic processGO:0062068.8DPYD, DPYS

Products for genes affiliated with Dihydropyrimidinase Deficiency

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dihydropyrimidinase Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet