DCM
MCID: DLT002
MIFTS: 82

Dilated Cardiomyopathy (DCM) malady

Cardiovascular diseases, Genetic diseases categories

Summaries for Dilated Cardiomyopathy

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Dilated cardiomyopathy is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. it is the most common type of cardiomyopathy and typically affects those aged 20 to 60. the left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. the heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. over time, the heart becomes weaker and heart failure can occur. while the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired or inherited. last updated: 9/29/2011

MalaCards: Dilated Cardiomyopathy, also known as primary dilated cardiomyopathy, is related to myocarditis and hypertrophic cardiomyopathy. An important gene associated with Dilated Cardiomyopathy is VCL (vinculin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoskeletal Signaling. The drugs inamrinone and inamrinone lactate and the compounds lipid and calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and liver, and related mouse phenotypes are muscle and mortality/aging.

Disease Ontology:8 An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart.

Wikipedia:63 Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot... more...

Description from OMIM:46 604145, 613642, 613252, 609909, 613286 613881, 613172, 607487, 613122, 613697, 300069, 611407, 605362, 613426, 606685, 601493, 608569, 611615, 611878, 613740, 601154, 604765, 612877, 613424, 302045, 613694, 611880, 607482, 612158, 614672, 611879, 115200, 601494 more

GeneReviews summary for dcm-ov

Aliases & Classifications for Dilated Cardiomyopathy

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Sources:
8Disease Ontology, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 38NCBI Bookshelf, 30LifeMap Discovery™, 60UMLS, 46OMIM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

dilated cardiomyopathy 8 19 42 20 10 44 30
primary dilated cardiomyopathy 8 22
dcm 42 38
cardiomyopathy, familial idiopathic 60
idiopathic dilated cardiomyopathy 42
cardiomyopathy, congestive 8
cardiomyopathy, dilated 60
diastrophic dysplasia 60


Related Diseases for Dilated Cardiomyopathy

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17GeneCards, 18GeneDecks
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Diseases in the Dilated Cardiomyopathy family:

Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines
Familial Dilated Cardiomyopathy Taz-Related Dilated Cardiomyopathy
Tnnt2-Related Dilated Cardiomyopathy Myh7-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Tpm1-Related Dilated Cardiomyopathy
Des-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Ldb3-Related Dilated Cardiomyopathy Pln-Related Dilated Cardiomyopathy
Scn5a-Related Dilated Cardiomyopathy Dmd-Related Dilated Cardiomyopathy
Ttn-Related Dilated Cardiomyopathy Csrp3-Related Dilated Cardiomyopathy
Tcap-Related Dilated Cardiomyopathy Abcc9-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy Actn2-Related Dilated Cardiomyopathy
Tnnc1-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Psen2-Related Dilated Cardiomyopathy Psen1-Related Dilated Cardiomyopathy
Eya4-Related Dilated Cardiomyopathy Tmpo-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Dsg2-Related Dilated Cardiomyopathy
Nexn-Related Dilated Cardiomyopathy Rbm20-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1ll Cardiomyopathy, Dilated, 1cc
Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1aa
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 1e Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1jj Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated 1b
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1kk
Cardiomyopathy, Dilated, 1w Cardiomyopathy, Dilated 1c
Cardiomyopathy, Dilated, 1dd Cardiomyopathy, Dilated, 1hh
Cardiomyopathy, Dilated, 1m Cardiomyopathy, Dilated, 1mm
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1o
Cardiomyopathy, Dilated, 1t Cardiomyopathy, Dilated, 1ee
Cardiomyopathy, Dilated, 1s Cardiomyopathy, Dilated, 1u
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1n
Cardiomyopathy, Dilated, 1bb Cardiomyopathy, Dilated, 2a
Cardiomyopathy, Dilated, 1ff

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis31.2DMD, TNNT2
2hypertrophic cardiomyopathy31.1CSRP3, TNNT2, MYH7, ACTC1
3congestive heart failure30.9TNNT2
4muscular dystrophy30.8SGCD, LMNA, FKTN, DMD
5dmd-associated dilated cardiomyopathy30.8TAZ, DMD
6myopathy30.8FKTN, TNNT2, DMD, LDB3, MYH7, TAZ
7endocardial fibroelastosis30.6TAZ
8becker muscular dystrophy30.5DMD
9familial hypertrophic cardiomyopathy30.5CSRP3, ACTC1, TNNT2, MYH7, PLN
10duchenne muscular dystrophy30.4DMD
11nemaline myopathy30.4ACTC1
12emery-dreifuss muscular dystrophy30.3LMNA, DMD, TMPO
13myocardial infarction30.3TNNT2, LDB3, VCL
14barth syndrome30.1LDB3, TAZ, DNAJC19
15neuropathy30.1LMNA, DMD, SGCD, FKTN
16limb-girdle muscular dystrophy29.9LMNA, DMD, FKTN
17sudden cardiac death multi-gene panels29.9LMNA, TNNT2, MYH7
18myotonic dystrophy29.9DMD, MYH7
19diastrophic dysplasia11.1
20familial dilated cardiomyopathy10.6
21acute myocarditis10.5
22atelosteogenesis10.4
23hypertension10.4
24restrictive cardiomyopathy10.4
25wolff-parkinson-white syndrome10.4
26rickets10.4
27peripartum cardiomyopathy10.4
28chagas disease10.3
29cardiomyopathy dilated with woolly hair and keratoderma10.3
30cardiomyopathy, dilated, 1a10.3
31atrioventricular block10.3
32cushing's syndrome10.3
33epidermolysis bullosa10.3
34hepatitis10.3
35lmna-related dilated cardiomyopathy10.3
36coronary artery disease10.3
37conduct disorder10.3
38respiratory failure10.3
39cardiomyopathy, dilated, 1j10.3
40cardiomyopathy, dilated, 1w10.3
41multiple epiphyseal dysplasia10.2
42otosclerosis10.2
43pseudoachondroplasia10.2
44achondrogenesis10.2
45multiple epiphyseal dysplasia, recessive10.2
46diastrophic dysplasia, broad bone-platyspondylic variant10.2
47hepatitis c10.2
48sensorineural hearing loss10.2
49cardiac sarcoidosis10.2
50hypoparathyroidism10.2

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to dilated cardiomyopathy

Clinical Features for Dilated Cardiomyopathy

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Sources:
46OMIM
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Drugs & Therapeutics for Dilated Cardiomyopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dilated Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Dilated Cardiomyopathy

Search NIH Clinical Center for Dilated Cardiomyopathy

Search CenterWatch for Dilated Cardiomyopathy

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.

Genetic Tests for Dilated Cardiomyopathy

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Dilated Cardiomyopathy20 VCL
2 Primary Dilated Cardiomyopathy22

Anatomical Context for Dilated Cardiomyopathy

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Dilated Cardiomyopathy:

32
Heart, Bone, Liver, Lung, Monocytes, Testes, Brain, Skeletal muscle, T cells, Endothelial, Bone marrow, Kidney, Thyroid, Spleen, Whole blood, B cells, Eye, Cardiac myocytes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
id TissueAnatomical CompartmentCell Relevance
1 HeartMyocardiumCardiomyocytes Affected by disease
2 HeartLeft VentricleCardiomyocytes Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Dilated Cardiomyopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536911.9LDB3, PDCD1, CSRP3, TNNT2, DMD, FKTN
2MP:001076811.8DMD, TNNT2, CSRP3, PDCD1, EYA4, FKTN
3MP:000538511.7DMD, TNNT2, CSRP3, PDCD1, PLN, LMNA
4MP:000537811.6CSRP3, TNNT2, DMD, FKTN, LMNA, ACTC1
5MP:000538110.9EYA4, DMD, LMNA, VCL, TMPO, LDB3

Publications for Dilated Cardiomyopathy

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50PubMed
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Articles related to Dilated Cardiomyopathy:

(show top 50)    (show all 1356)
idTitleAuthorsYear
1
Sphericity Index and E-Point-to-Septal-Separation (EPSS) to Diagnose Dilated Cardiomyopathy in Doberman Pinschers. (24428318)
2014
2
Intraventricular vortex properties in non-ischemic dilated cardiomyopathy. (24414062)
2014
3
Prediction of improvement in cardiac function by high dose dobutamine stress echocardiography in patients with recent onset idiopathic dilated cardiomyopathy. (23312406)
2013
4
A1180V of cardiac sodium channel gene (SCN5A): is it a risk factor for dilated cardiomyopathy or just a common variant in Han Chinese? (24227891)
2013
5
The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy -- 5-year follow-up. (23566246)
2013
6
Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation I9K210. (23863340)
2013
7
The prevalence and prognostic significance of right ventricular systolic dysfunction in nonischemic dilated cardiomyopathy. (23965488)
2013
8
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy. (23313350)
2013
9
Clinical characteristics, morbidity, and prognostic value of concomitant coronary artery disease in idiopathic dilated cardiomyopathy. (23800786)
2013
10
Five-week use of a monopivot centrifugal blood pump as a right ventricular assist device in severe dilated cardiomyopathy. (24288020)
2013
11
Prognostic implications of fragmented QRS and its relationship with delayed contrast-enhanced cardiovascular magnetic resonance imaging in patients with non-ischemic dilated cardiomyopathy. (22552168)
2013
12
LMNA mutations in Polish patients with dilated cardiomyopathy: prevalence, clinical characteristics, and in vitro studies. (23702046)
2013
13
Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy. (22892539)
2013
14
Circulating microRNAs levels in Chinese heart failure patients caused by dilated cardiomyopathy. (23438607)
2013
15
Postconditioning protects against reperfusion injury in hypertensive dilated cardiomyopathy by activating MEK/ERK1/2 signaling. (23384639)
2013
16
Exercise-induced ST elevation in patients with non-ischemic dilated cardiomyopathy and narrow QRS complexes: novel predictor of long-term prognosis from exercise testing. (23291994)
2013
17
Case scenario about TEE: Patient with dilated cardiomyopathy undergoing laparoscopic cholecystectomy. (24353604)
2013
18
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy. (23853074)
2013
19
Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy. (23357302)
2013
20
TNNT2 gene polymorphisms are associated with susceptibility to idiopathic dilated cardiomyopathy in the Han Chinese population. (23586019)
2013
21
Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. (23631840)
2013
22
Loss of I+T-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. (22421363)
2012
23
Mean platelet volume in patients with dilated cardiomyopathy and left ventricular thrombus. (22977261)
2012
24
Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy. (21689390)
2011
25
Familial dilated cardiomyopathy associated with congenital defects in the setting of a novel VCL mutation (Lys815Arg) in conjunction with a known MYPBC3 variant. (24062880)
2011
26
Homozygosity mapping and exome sequencing reveal GATAD1 mutation in autosomal recessive dilated cardiomyopathy. (21965549)
2011
27
Relationship between biological variation in B-type natriuretic peptide and plasma renin concentration in stable outpatients with dilated cardiomyopathy. (21697610)
2011
28
Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy. (21768101)
2011
29
Dilated cardiomyopathy caused by a novel TNNT2 mutation-added value of genetic testing in the correct identification of affected subjects. (19324435)
2010
30
Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. (19001090)
2009
31
Structural kinetics of cardiac troponin C mutants linked to familial hypertrophic and dilated cardiomyopathy in troponin complexes. (18063575)
2008
32
Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. (18585512)
2008
33
Cardiac sarcoidosis underlies idiopathic dilated cardiomyopathy: importance of mediastinal lymphadenopathy in differential diagnosis. (18037750)
2007
34
Mutations in the cardiac Troponin C gene are a cause of idiopathic dilated cardiomyopathy in childhood. (17977476)
2007
35
Relation of B-type natriuretic peptide levels before and after exercise and functional capacity in patients with idiopathic dilated cardiomyopathy. (17478157)
2007
36
Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy. (15093997)
2004
37
Quantitative analysis of peroxisome proliferator-activated receptor gamma (PPARgamma) expression in arteries and hearts of patients with ischaemic or dilated cardiomyopathy. (14675851)
2003
38
Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents. (11986409)
2002
39
Sudden cardiac death in dilated cardiomyopathy -- therapeutic options. (12574892)
2002
40
Beneficial effects of pentoxifylline in patients with idiopathic dilated cardiomyopathy treated with angiotensin-converting enzyme inhibitors and carvedilol: results of a randomized study. (11222470)
2001
41
Borjeson-Forssman-Lehmann syndrome and dilated cardiomyopathy: a previously unreported association. (11173318)
2001
42
Antioxidative enzymes in human hearts with idiopathic dilated cardiomyopathy. (10652196)
2000
43
The somatotrophic system in patients with dilated cardiomyopathy: relation of insulin-like growth factor-1 and its alterations during growth hormone therapy to cardiac function. (10931081)
2000
44
Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese. (10425186)
1999
45
Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. (10072227)
1999
46
Point mutations in mitochondrial DNA of patients with dilated cardiomyopathy. (9344764)
1997
47
Iatrogenically induced intractable atrioventricular reentrant tachycardia after verapamil and catheter ablation in a patient with Wolff-Parkinson-White syndrome and idiopathic dilated cardiomyopathy. (9249847)
1997
48
Combined 3-methylglutaconic and 3-hydroxy-3-methylglutaric aciduria with endocardial fibroelastosis and dilatative cardiomyopathy in male and female siblings with partial deficiency of complex II/III in fibroblasts. (9252790)
1996
49
Dilating cardiomyopathy as the expression of Xp21 Becker type muscular dystrophy. (1431989)
1992
50
Familial dilated cardiomyopathy and human leucocyte antigen. A report of two family cases. (3444043)
1987

Genetic Variations for Dilated Cardiomyopathy

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Expression for genes affiliated with Dilated Cardiomyopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dilated Cardiomyopathy

Search GEO for disease gene expression data for Dilated Cardiomyopathy.

Pathways for genes affiliated with Dilated Cardiomyopathy

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Sources:
29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
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Compounds for genes affiliated with Dilated Cardiomyopathy

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipid4411.2MYH7, TAZ, PLN, LMNA, VCL, DMD
2calcium44 49 11 2414.1TNNT2, DMD, MYH7, PLN, LMNA, ACTC1
3creatinine4411.1ACTC1, LMNA, MYH7, DMD, TNNT2
4alpha-bungarotoxin44 5911.6DMD, TMPO

GO Terms for genes affiliated with Dilated Cardiomyopathy

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16Gene Ontology
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Cellular components related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Z discGO:03001811.3LDB3, VCL, MYH7, NEXN, DMD, CSRP3
2cytoskeletonGO:00585611.2CSRP3, NEXN, SGCD, VCL, LDB3
3sarcomereGO:03001710.8ACTC1, MYH7, TNNT2
4cell-substrate junctionGO:03005510.8DMD, VCL
5sarcolemmaGO:04238310.7DMD, SGCD, VCL
6costamereGO:04303410.7VCL, DMD
7dystrophin-associated glycoprotein complexGO:01601010.4SGCD, DMD

Biological processes related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004911.2ACTC1, MYH7, DMD, TNNT2
2cardiac muscle contractionGO:06004811.2ACTC1, TAZ, DMD, CSRP3
3muscle organ developmentGO:00751711.2SGCD, LMNA, FKTN, DMD
4cardiac muscle tissue developmentGO:04873811.1CSRP3, TAZ, PLN
5ATP catabolic processGO:00620011.0TNNT2, MYH7, ACTC1
6muscle contractionGO:00693611.0VCL, TAZ, MYH7
7negative regulation of ATPase activityGO:03278010.9PLN, TNNT2
8cardiac myofibril assemblyGO:05500310.9ACTC1, CSRP3
9regulation of ryanodine-sensitive calcium-release channel activityGO:06031410.8PLN, DMD
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:01088110.7DMD, PLN
11regulation of heart rateGO:00202710.7MYH7, DMD
12regulation of the force of heart contractionGO:00202610.6PLN, CSRP3
13sarcomere organizationGO:04521410.4LDB3, TNNT2

Molecular functions related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:00830711.0MYH7, NEXN, DMD, CSRP3
2actin bindingGO:00377910.9TNNT2, DMD, MYH7, VCL
3dystroglycan bindingGO:00216210.7VCL, DMD
4myosin bindingGO:01702210.7ACTC1, DMD
5ATPase activityGO:01688710.5ACTC1, MYH7, TNNT2

Products for genes affiliated with Dilated Cardiomyopathy

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  • Antibodies
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Sources for Dilated Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet