Dilated Cardiomyopathy malady

Disease Ontology: An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently.⁶

MalaCards: Dilated Cardiomyopathy, also known as primary dilated cardiomyopathy (disorder), is related to dmd-associated dilated cardiomyopathy and familial hypertrophic cardiomyopathy. An important gene associated with Dilated Cardiomyopathy is LMNA (lamin A/C), and among its related pathways are Dilated cardiomyopathy and Hypertrophic cardiomyopathy (HCM). The drugs amrinone and amrinone lactate and the compounds ryanodine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are mortality/aging and muscle.

GeneReviews summary for dcm-ov

Aliases & Descriptions:

dilated cardiomyopathy 6 15 30 16 primary dilated cardiomyopathy (disorder) 6 idiopathic dilated cardiomyopathy 30 cardiomyopathy, congestive 6

cardiomyopathy, dilated 43 cardiomyopathies 43 dcm 30

Disease types for dilated cardiomyopathy family:

cardiomyopathy, dilated 1b	cardiomyopathy, dilated, 1f
cardiomyopathy, dilated, 1h	cardiomyopathy, dilated, 1k
cardiomyopathy, dilated, 1q	cardiomyopathy, dilated, 2a
cardiomyopathy, dilated, 1ff	cardiomyopathy, dilated, 1gg
cardiomyopathy, dilated, 1z	cardiomyopathy, dilated, 1g

Diseases related to dilated cardiomyopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1136)

id	Related Disease	Score	Top Affiliating Genes
1	dmd-associated dilated cardiomyopathy	41.5	PIK3C2A, PDE3A, REN, SGCA, SGCD, VWF
2	familial hypertrophic cardiomyopathy	40.3	VCL, MYBPC3, MYOZ2, MYBPC1, MYBPC2, JPH2
3	familial dilated cardiomyopathy	40.1	RBM20, LMNA, MYOZ2, MYOZ1, CMD1B, CMD1D
4	muscular dystrophy	36.9	PIK3C2A, SGCA, SGCD, LMNA, MYOT, UTRN
5	congestive heart failure	36.6	PIK3C2A, REN, CHRM2, CHKB, XDH, FN1
6	hypertrophic cardiomyopathy	35.3	PIK3C2A, REN, SGCA, SGCD, VWF, VCL
7	noonan syndrome	34.4	PIK3C2A, PDE3A, REN, SGCA, SGCD, VWF
8	myocarditis	34.2	PIK3C2A, SGCA, SGCD, MYBPC1, MYH7B, MYOCD
9	familial restrictive cardiomyopathy	34.2	MYBPC3, MYPN, MAPK8, TPM1, TNNC1, TNNI3
10	myopathy	33.0	PIK3C2A, SGCA, LMNA, MYOZ2, MYBPC1, MYOT
11	arrhythmogenic right ventricular dysplasia/cardiomyopathy multi-gene panels	32.7	PIK3C2A, REN, SGCD, RBM20, SERPINE1, VCL
12	ischemic heart disease	32.6	PIK3C2A, SERPINE1, VCL, CHKB, JAK2, FGA
13	hypertension	32.5	REN, CYP11B2, NOS2, NOS3, ACE, AGT
14	sudden cardiac death multi-gene panels	32.2	LMNA, MYBPC3, SCN5A, MMP3, MB, CAV3
15	left ventricular noncompaction	31.8	LMNA, MYBPC3, CMD1D, SCN5A, LDB3, TPM1
16	pulmonary hypertension	31.3	VCL, FGA, TNC, NOS2, NOS3, EDN1
17	endocardial fibroelastosis	31.2	ACTN2, TAZ, CSRP1, CSRP3, NPPA, NPPB
18	emery-dreifuss muscular dystrophy	31.1	LMNA, LAMA2, TMPO, DMD, SUN2, EMD
19	limb-girdle muscular dystrophy	30.7	SGCA, FKRP, DYSF, DMD, TCAP
20	acute myocarditis	30.5	CD70, FGA, FABP3, FAS, TNC, PLAT
21	pulmonary embolism	30.5	PIK3C2A, SERPINE1, INS, FGA, FABP3, F5
22	alcoholism	30.3	CHRM2, GSR, IL1RN, GHRL, CYP2E1, G6PD
23	myofibrillar myopathy	30.3	MYOT, LDB3, DYSF, TTN, DES
24	duchenne muscular dystrophy	30.1	PIK3C2A, SGCA, SGCD, VCL, MYOZ2, UTRN
25	becker muscular dystrophy	30.1	VCL, MYOZ2, UTRN, CHKB, FKRP, ALB
26	hypotonia	29.9	GCH1, LMNA, MT-CO1, LAMA2, QDPR, FKTN
27	hepatitis	29.8	SERPINA1, XDH, CDH5, GSR, IL2RB, FAS
28	ventricular fibrillation	29.8	SERPINE1, SCN5A, CHKB, MMP9, FGA, MB
29	obsessive-compulsive disorder	29.6	FOXD4, IL6, APOE, CAT, GHRL, TNF
30	hepatitis c	29.5	SERPINA1, CD40LG, MMP1, GSR, IL10, IL18
31	sensorineural hearing loss	29.3	SERPINE1, MT-ND5, MT-CO1, XPNPEP3, IL1A, APOE
32	atrial fibrillation	28.8	PIK3C2A, REN, VWF, PCNA, SERPINE1, LMNA
33	pericarditis	28.5	PIK3C2A, REN, IL2, IL6, ALB, TNF
34	congenital heart defect	28.5	LMNA, GJA1, GJA5, TNC, PTPN11, DSP
35	glycogen storage disease	28.4	VWF, CKM, CHKB, LAMP2, MPP2, INS
36	nemaline myopathy	28.4	MYPN, MYOT, TPM1, TNNT1, TNNT2, ACTC1
37	encephalomyopathy	28.3	MT-ND5, MT-CO1, MB, HSPD1, CAT, GH1
38	lipodystrophy	28.3	SERPINE1, LMNA, INS, IL18, IL6, APOE
39	hearing loss	28.1	SGCA, SERPINE1, MT-ND5, MT-CO1, XPNPEP3, XDH
40	hypertensive heart disease	27.9	CD36, MMP1, MMP9, TPM1, CYP11B2, CTF1
41	mitochondrial encephalomyopathy	27.8	CHKB, MT-CO1, HSPD1, COX5A, TFAM, POLG
42	hemochromatosis	27.8	REN, SERPINA1, B2M, INS, IL6, APOE
43	heart block	27.6	SERPINE1, LMNA, SCN5A, CKM, CALR, TNF
44	fabry disease	27.5	VWF, IL10, IL1A, IL6, F5, TNF
45	growth hormone deficiency	27.4	REN, SERPINE1, XDH, CD36, CD40LG, MMP2
46	spasticity	27.3	PDCD1, SGCD, GCH1, B2M, ITGAL, MMP9
47	parkinson's disease	27.1	GCH1, SERPINA3, CHKB, MT-ND5, GSR, APOE
48	aldosteronism	27.0	REN, GCH1, SERPINE1, MYBPC3, CHGA, B2M
49	chagas disease	26.6	SERPINE1, MYD88, CHRM2, XDH, CD40LG, FOS
50	autoimmune myocarditis	26.4	IL2, CCL2, TNF, SPP1, CTLA4, PPARG

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 amrinone, amrinone lactate

Cell-based therapeutics:

Genetic tests related to dilated cardiomyopathy:

id	Genetic test	Affiliating Genes
1	Dilated Cardiomyopathy clinical/research	SGCD, RBM20, VCL, LMNA, MYBPC3, SCN5A, LDB3, BAG3, FKTN, ANKRD1 (show all 29) EYA4, TPM1, TNNT2, TMPO, PLN, ABCC9, ACTN2, ACTC1, TTN, DSG2, TCAP, TAZ, DES, PSEN1, PSEN2, CSRP3, NEXN, MYH6, MYH7

MalaCards organs/tissues related to dilated cardiomyopathy:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Heart -> Left Ventricle -> Cardiomyocytes	Potential therapeutic candidate, affected by disease
2	Heart -> Myocardium -> Cardiomyocytes	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to dilated cardiomyopathy:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	12.7	PIK3C2A, PDCD1, REN, SGCD, VWF, SERPINE1
2	muscle phenotype	MP:0005369	12.2	PDCD1, REN, SGCA, SGCD, VCL, LMNA
3	respiratory system phenotype	MP:0005388	11.7	NAB2, UTRN, CHRM2, LDB3, MEF2C, MEF2A
4	hematopoietic system phenotype	MP:0005397	11.5	PDCD1, PCNA, MYD88, BIRC6, ZBTB17, BAG3
5	craniofacial phenotype	MP:0005382	11.5	LAMA2, LAMP2, CDH5, FKRP, MEF2C, IL17A
6	endocrine/exocrine gland phenotype	MP:0005379	11.3	PAFAH1B1, PAFAH1B2, LAMA2, XDH, CD40LG, IL2
7	embryogenesis phenotype	MP:0005380	11.2	VCL, MYOCD, LIMS1, USP7, BIRC6, PAFAH1B2
8	other phenotype	MP:0005395	10.1	SGCD, LAMA2, JAK2, CD40LG, FN1, FKTN
9	nervous system phenotype	MP:0003631	10.0	PDCD1, REN, VWF, NAB2, VCL, LMNA
10	normal phenotype	MP:0002873	9.9	PDE3A, REN, NAB2, LMNA, MYOCD, MYOT
11	cardiovascular system phenotype	MP:0005385	9.7	PDCD1, REN, SGCA, SGCD, VWF, SERPINE1
12	limbs/digits/tail phenotype	MP:0005371	9.6	VCL, LMNA, UTRN, CHKB, MMP9, FN1
13	digestive/alimentary phenotype	MP:0005381	9.5	VWF, VCL, LMNA, LDB3, B2M, CD36
14	integument phenotype	MP:0010771	9.4	NAB2, BIRC6, ZBTB17, CHRM2, BAG3, LAMP2
15	pigmentation phenotype	MP:0001186	9.1	LMNA, ZBTB17, ILK, APOE, FAS, CCL2
16	no phenotypic analysis	MP:0003012	9.0	PCNA, MYD88, MYOT, BAG3, INS, IL13
17	skeleton phenotype	MP:0005390	8.3	NAB2, LMNA, MYD88, LAMA2, LAMP2, QDPR
18	tumorigenesis	MP:0002006	6.1	SERPINE1, MYD88, B2M, JAK2, CD34, ITGAL
19	growth/size phenotype	MP:0005378	INF	PIK3C2A, REN, SERPINE1, NAB2, VCL, LMNA
20	renal/urinary system phenotype	MP:0005367	INF	PDCD1, REN, LMNA, MYD88, UTRN, CHRM2
21	behavior/neurological phenotype	MP:0005386	INF	REN, NAB2, LMNA, MYD88, MYOZ1, UTRN
22	vision/eye phenotype	MP:0005391	INF	PDCD1, LMNA, MYD88, CHRM2, CD36, MMP2
23	reproductive system phenotype	MP:0005389	INF	PDE3A, REN, NAB2, LMNA, UTRN, PAFAH1B1
24	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, REN, SGCA, SGCD, VWF, SERPINE1
25	cellular phenotype	MP:0005384	INF	PDCD1, VWF, PCNA, NAB2, VCL, LMNA
26	adipose tissue phenotype	MP:0005375	INF	PIK3C2A, SERPINE1, LMNA, MYD88, BAG3, XDH
27	hearing/vestibular/ear phenotype	MP:0005377	INF	LMNA, MYD88, LAMA2, FOS, IL13, APOE
28	immune system phenotype	MP:0005387	INF	REN, SGCA, VWF, LMNA, MYD88, BIRC6
29	liver/biliary system phenotype	MP:0005370	INF	UTRN, BIRC6, CHRM2, BAG3, CD36, INS

Articles related to dilated cardiomyopathy:

(show top 50)    (show all 553)

id	Title	Authors	Year	Affiliating Genes
1	The effect of the dilated cardiomyopathy-causing Glu4 0Lys TPM1 mutation on actin-myosin interactions during the ATPase cycle. (21741356)	Borovikov Y.S.... Redwood C.S.	2011	TPM1
2	Fcgamma-receptor IIa polymorphism and the role of imm unoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy. (20054293)	Staudt A.... Felix S.B.	2010	FCGR2A
3	Autoimmune mechanisms underlying dilated cardiomyopathy. (19246813)	Yoshikawa T.... Nagatomo Y.	2009	CHRM2, ADRB1
4	Changes in natriuretic peptides following passive containment surgery in heart failure patients with dilated cardiomyopathy. (19008326)	Bredin F.... Franco-Cereceda A.	2009	NPPB, NPPA, NPPC
5	Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death. (19028670)	Zheng M.... Chen J.	2009	MYOT
6	Atorvastatin improves endothelial function and cardia c performance in patients with dilated cardiomyopathy: the role of inflammation . (19636689)	Liu M.... Jin R.	2009	VWF, CRP
7	HLA-DQB1* polymorphism and associations with dilated cardiomyopathy, inflammatory dilated cardiomyopathy and myocarditis. (19127454)	Portig I.... Maisch B.	2009	HLA-DQB1
8	Stress-induced dilated cardiomyopathy in a knock-in m ouse model mimicking human titin-based disease. (19406126)	Gramlich M.... Gerull B.	2009	TTN
9	Novel mutations in beta-myosin heavy chain, actin and troponin-I genes associated with dilated cardiomyopathy in Indian population. (20086309)	Boda U.... Nallari P.	2009	MYH7
10	Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report (19169978)	Nowicka A.... Wierzchowiecki M.	2008	PLAT
11	Heart transplantation in a child with LGMD2I presenting as isolated dilated cardiomyopathy. (18060779)	D'Amico A.... Bertini E.	2008	FKRP
12	A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. (18451336)	Zhang L.... Shen Y.	2008	CHRM2
13	Potential role of antibodies against cardiac Kv channel-interacting protein 2 in dilated cardiomyopathy. (18585502)	Landsberger M.... Felix S.B.	2008	ADRB1, KCNIP2
14	Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. (16387818)	Komamura K.... Kitakaze M.	2006	FABP3
15	Immunopathogenesis of dilated cardiomyopathy. Evidence for the role of TH2-type CD4+T lymphocytes and association with myocardial HLA-DR expression. (16418801)	Kuethe F.... Figulla H.R.	2006	IL2, IL4, IL5
16	An isoform shift in the cardiac adenine nucleotide translocase expression alters the kinetic properties of the carrier in dilated cardiomyopathy. (16107323)	Dorner A.... Schultheiss H.P.	2006	SLC25A4, SLC25A5, SLC25A5P8
17	Familial dilated cardiomyopathy with troponin T K210del mutation. (16789403)	Martins E.... Rocha-Goncalves F.	2006	TNNT2
18	Variation in the plasma concentration of B-type natriuretic peptide in emergent paroxysmal atrial fibrillation, in acute pulmonary embolism, in acute coronary syndrome and in dilated cardiomyopathy (16250184)	Coppola A.... Aguglia F.	2005	NPPB
19	Letter regarding article by McNair et al, 'SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia'. (15998690)	Groenewegen W.A.... Wilde A.A.	2005	SCN5A
20	Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy. (15556047)	Karkkainen S.... Peuhkurinen K.	2004	MYH7
21	Toll-like receptor 4 is expressed with enteroviral replication in myocardium from patients with dilated cardiomyopathy. (14688801)	Satoh M.... Hiramori K.	2004	TLR4
22	Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice. (14718401)	Yang L.L.... Stewart D.J.	2004	EDNRB, EDN1
23	Pentoxifylline in ischemic, hypertensive and idiopathic-dilated cardiomyopathy: effects on left-ventricular function, inflammatory cytokines and symptoms. (14984727)	Bahrmann P.... Figulla H.R.	2004	IL6, NPPB
24	Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization. (14654368)	Lu Q.W.... Ohtsuki I.	2003	TNNT2
25	Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects. (12898247)	Verga L.... Arbustini E.	2003	LMNA
26	Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. (12610310)	Schmitt J.P.... Seidman C.E.	2003	PLN
27	Common pathways for primary hypertrophic and dilated cardiomyopathy. (12713689)	Kroumpouzou E.... Toutouzas P.	2003	FOS
28	Different functional properties of troponin T mutants that cause dilated cardiomyopathy. (12923187)	Venkatraman G.... Potter J.D.	2003	TNNT2
29	Novel mutations in sarcomeric protein genes in dilated cardiomyopathy. (12379228)	Daehmlow S.... Regitz-Zagrosek V.	2002	MYH7
30	Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia. (12380923)	Kitamura H.... Yokoyama M.	2002	GJA1
31	Beneficial effects of pentoxifylline in patients with idiopathic dilated cardiomyopathy treated with angiotensin-converting enzyme i nhibitors and carvedilol: results of a randomized study. (11222470)	Skudicky D.... Sareli P.	2001	ACE
32	A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy. (11601839)	Herrmann S.... Osterziel K.J.	2001	EDNRB, EDNRA, EDN1
33	Impaired ability to secrete atrial natriuretic peptide in response to isoproterenol infusion in patients with dilated cardiomyopathy. (11200651)	Nishi I.... Yamaguchi I.	2001	NPPA
34	Damaged myocytes as detected by the colocalization of DNA fragmentation and tissue transglutaminase and their prognostic significance in enterovirus-associated dilated cardiomyopathy. (11589716)	Lotze U.... Figull H.R.	2001	TGM2
35	Dilated cardiomyopathy and sensorineural hearing loss: a heritable syndrome that maps to 6q23-24. (10769282)	Schonberger J.... Seidman C.E.	2000	EYA4
36	Marked and prompt hemodynamic improvement by carperit ide in refractory congestive heart failure due to dilated cardiomyopathy. (11041104)	Kikuchi M.... Hiramori K.	2000	NPPA
37	Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy. (10974018)	Tsubata S.... Towbin J.A.	2000	PPARG, TAZ, SGCD
38	Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy. (10368118)	Heymes C.... Paulus W.J.	1999	NOS3, NOS2
39	Cardiac and skeletal actin gene mutations are not a common cause of dilated cardiomyopathy. (10528865)	Mayosi B.M.... Watkins H.	1999	ACTC1
40	Genomic characterization of the human peptidyl-prolyl-cis-trans-isomerase, mitochondrial precursor gene: assessment of its role in familial dilated cardiomyopathy. (10647893)	Bowles K.R.... Towbin J.A.	1999	PPIF
41	Point mutations in mitochondrial DNA of patients with dilated cardiomyopathy. (9344764)	Li Y.Y.... Hengstenberg C.	1997	MT-CO1, MT-ND5
42	Anti-M2 muscarinic receptor autoantibodies and idiopathic dilated cardiomyopathy. (8803676)	Fu M.L.	1996	CHRM2
43	Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. (8651123)	Munger M.A.... Gilbert E.M.	1996	TNF, IL2RA, IL6
44	Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. (7586307)	Schwinger R.H.... Erdmann E.	1995	PLN
45	Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease. (7488459)	de Belder A.J.... Martin J.F.	1995	NOS2
46	Dilated cardiomyopathy in acromegaly worsening under octreotide treatment. Apropos of a case (8498802)	Leclercq F.... Grolleau R.	1993	GH1
47	Dilating cardiomyopathy as the expression of Xp21 Becker type muscular dystrophy. (1431989)	Palmucci L.... Paolillo V.	1992	DMD
48	Myocardial catecholamine and neuropeptide Y depletion in failing ventricles of patients with idiopathic dilated cardiomyopathy. Correlation with beta-adrenergic receptor downregulation. (1309447)	Anderson F.L.... Bristow M.R.	1992	NPY, ADRB1
49	Effects of treatment of arrhythmias requiring therapy in dilated cardiomyopathy with amiodarone on alpha human atrial natriuretic peptide (1414168)	Zirm B.... Hartter E.	1992	ACE
50	Mapping of a functional autoimmune epitope on the bet a 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. (1700798)	Magnusson Y.... Hoebeke J.	1990	ADRB2

Genes related to dilated cardiomyopathy according to GeneCards:

(show top 50)    (show all 325)

id	Symbol	Description	Score	GeneCards Section Context
1	LMNA	lamin A/C	11.1	Summaries, Publications
2	TAZ	tafazzin	11.1	Publications, Summaries
3	TNNT2	troponin T type 2 (cardiac)	11.1	Publications, Summaries
4	LDB3	LIM domain binding 3	11.1	Publications, Summaries
5	PLN	phospholamban	11.1	Summaries, Publications
6	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	11.1	Publications, Summaries
7	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.1	Publications, Summaries
8	ACTC1	actin, alpha, cardiac muscle 1	11.1	Summaries, Publications
9	VCL	vinculin	11.1	Summaries, Publications
10	RBM20	RNA binding motif protein 20	11.1	Publications, Summaries
11	TMPO	thymopoietin	11.1	Summaries, Publications
12	DNAJC19	DnaJ (Hsp40) homolog, subfamily C, member 19	11.1	Summaries
13	FOXD4	forkhead box D4	11.1	Publications, Summaries
14	NEXN	nexilin (F actin binding protein)	11.1	Publications, Summaries
15	FKTN	fukutin	11.1	Publications, Summaries
16	EYA4	eyes absent homolog 4 (Drosophila)	11.1	Publications, Summaries
17	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	11.1	Summaries, Publications
18	GATAD1	GATA zinc finger domain containing 1	11.0	Summaries
19	PDCD1	programmed cell death 1	11.0	Summaries
20	SUN2	Sad1 and UNC84 domain containing 2	11.0	Publications
21	TTN	titin	11.0	Publications
22	CHRM2	cholinergic receptor, muscarinic 2	11.0	Publications
23	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
24	DMD	dystrophin	11.0	Publications
25	DSP	desmoplakin	11.0	Publications
26	MEF2A	myocyte enhancer factor 2A	11.0	Publications
27	CMD1F	cardiomyopathy, dilated 1F (autosomal dominant)	11.0	Publications
28	CMD1B	cardiomyopathy, dilated 1B (autosomal dominant)	11.0	Publications
29	CMD1D	cardiomyopathy, dilated 1D (autosomal dominant)	11.0	Publications
30	TNNC1	troponin C type 1 (slow)	11.0	Publications
31	TCAP	titin-cap (telethonin)	11.0	Publications
32	MURC	muscle-related coiled-coil protein	11.0	Publications
33	MYOZ1	myozenin 1	11.0	Publications
34	TNNI3	troponin I type 3 (cardiac)	11.0	Publications
35	ADRB1	adrenoceptor beta 1	11.0	Publications
36	TPM1	tropomyosin 1 (alpha)	11.0	Publications
37	MYBPC3	myosin binding protein C, cardiac	11.0	Publications
38	PPIF	peptidylprolyl isomerase F	11.0	Publications
39	CTF1	cardiotrophin 1	11.0	Functions, Publications
40	SGCA	sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)	11.0	Publications
41	EMD	emerin	11.0	Publications
42	FKRP	fukutin related protein	11.0	Publications
43	DES	desmin	11.0	Publications
44	GJA5	gap junction protein, alpha 5, 40kDa	11.0	Publications
45	MYOZ2	myozenin 2	11.0	Publications
46	LAMP2	lysosomal-associated membrane protein 2	11.0	Publications
47	NPPB	natriuretic peptide B	11.0	Publications
48	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	11.0	Publications
49	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	11.0	Publications
50	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	11.0	Publications

Pathways related to dilated cardiomyopathy according to GeneDecks:

(show top 50)    (show all 131)

id	Pathway	Score	Top Affiliating Genes
1	Dilated cardiomyopathy20	12.0	SGCA, SGCD, LMNA, MYBPC3, LAMA2, IGF1
2	Hypertrophic cardiomyopathy (HCM)20	11.8	SGCA, SGCD, LMNA, MYBPC3, LAMA2, IL6
3	Viral myocarditis20	11.8	SGCA, SGCD, MYH7B, LAMA2, CD40LG, ITGAL
4	Arrhythmogenic right ventricular cardiomyopathy (ARVC)20	11.4	SGCA, SGCD, LMNA, LAMA2, CDH2, GJA1
5	Striated Muscle Contraction38	11.2	MYBPC3, MYBPC1, MYBPC2, TPM1, TNNC1, TNNI1
6	Antiarrhythmic Pathway, Pharmacodynamics34	11.2	LMNA, KCNIP2, SCN5A, CHRM2, ATP1A1, GJA1
7	THC Differentiation Pathway36	10.5	IL10, IL18, IL18R1, IL2, IL2RA, IL4
8	Asthma20	10.5	CD40LG, IL10, IL13, IL4, IL5, HLA-DPA1
9	Rheumatoid arthritis20	10.4	ATP6V1G2, ITGAL, MMP1, MMP3, FOS, IL17A
10	PGC1Alpha Pathway36	10.4	MEF2C, MEF2A, IL13, IL18, IL1A, IL2
11	Type I diabetes mellitus20	10.4	INS, IL1A, IL2, FAS, HSPD1, HLA-DPA1
12	Allograft rejection20	10.4	CD40LG, IL10, IL2, IL4, IL5, FAS
13	Graft-versus-host disease20	10.3	IL1A, IL2, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DRB4
14	Toxoplasmosis20	10.2	MYD88, LAMA2, LAMB4, JAK2, CD40LG, IL10
15	Akt Signaling36	10.2	ITGAL, IL10, IL18, IL18R1, IL2, IL2RA
16	Autoimmune thyroid disease20	10.1	CD40LG, IL10, IL2, IL4, IL5, FAS
17	Leishmaniasis20	10.0	MYD88, JAK2, FOS, FCGR2A, IL10, IL1A
18	Th1 Differentiation37	10.0	JAK2, FOS, IL10, IL18, IL18R1, IL2
19	ILK Signaling36	10.0	MYH7B, LIMS1, PARVB, LAMA2, LAMB4, CDH2
20	IL-6 Pathway36	10.0	IL10, IL18, IL4, IL5, IL6R, IL6ST
21	Influenza A20	10.0	MYD88, JAK2, IL18, IL1A, IL6, FAS
22	Intestinal immune network for IgA production20	10.0	CD40LG, IL10, IL2, IL4, IL5, IL6
23	Malaria20	9.7	MYD88, CD36, CD40LG, ITGAL, IL10, IL18
24	Tuberculosis20	9.7	MYD88, LAMP2, JAK2, FCGR2A, IL10, IL18
25	Epithelial Adherens Junctions36	9.6	VCL, MYH7B, CDH2, IL2, GH1, ERBB2
26	Focal adhesion20	9.6	VWF, VCL, PARVB, LAMA2, LAMB4, FN1
27	Jak-STAT signaling pathway20	9.4	JAK2, IL10, IL13, IL2, IL23R, IL2RA
28	Cytokine Network36	9.4	IL10, IL13, IL18, IL1A, IL2, IL4
29	MIF Mediated Glucocorticoid Regulation36	9.3	IL10, IL13, IL18, IL1A, IL2, IL4
30	Chagas disease (American trypanosomiasis)20	9.3	SERPINE1, MYD88, FOS, IL10, IL2, IL6
31	MIF Regulation of Innate Immune Cells36	9.3	FOS, IL10, IL13, IL18, IL1A, IL2
32	PEDF Induced Signaling36	9.2	FOS, IL10, IL13, IL18, IL1A, IL2
33	STAT3 Pathway36	9.2	JAK2, IL10, IL13, IL18, IL18R1, IL1A
34	Glucocorticoid Receptor Signaling36	9.1	FOS, IL10, IL13, IL18, IL18R1, IL1A
35	Endothelin-1 Signaling Pathway36	8.9	IL10, IL13, IL18, IL1A, IL2, IL4
36	Rho Family GTPases36	8.9	LAMA2, LAMB4, CDH2, CDH5, ITGAL, FOS
37	Measles20	8.8	MYD88, JAK2, CD46, IL13, IL1A, IL2
38	PAK Pathway36	8.7	MYH7B, IL10, IL13, IL18, IL1A, IL2
39	Cytokine-cytokine receptor interaction20	8.7	CD70, CD40LG, IL10, IL13, IL17A, IL18
40	TGF-Beta Pathway36	8.3	FOS, IL10, IL13, IL18, IL18R1, IL1A
41	MAPK Family Pathway36	8.2	IL10, IL13, IL18, IL18R1, IL1A, IL2
42	Antioxidant Action of Vitamin-C36	8.2	MYH7B, JAK2, FOS, IL10, IL13, IL18
43	Activation of PKA through GPCR36	8.2	PDE3A, IL2, IL6, IGF1, GNAZ, GH1
44	ERK Signaling36	8.2	LAMA2, LAMB4, ITGAL, FN1, IL10, IL13
45	Molecular Mechanisms of Cancer36	8.1	LAMA2, LAMB4, ITGAL, FOS, FN1, IL13
46	cAMP Pathway36	8.0	PDE3A, SCN5A, IL2, IL2RA, IL6, MAPK7
47	MAPK Signaling36	7.8	VCL, LAMA2, LAMB4, ITGAL, FOS, FN1
48	JAK-STAT Pathway36	7.2	JAK2, FOS, IL10, IL13, IL18, IL18R1
49	Tec Kinases Signaling36	7.2	MYD88, JAK2, ITGAL, FOS, IL10, IL13
50	p38 Signaling36	7.1	MEF2C, MEF2A, IL10, IL13, IL18, IL18R1

Compounds related to dilated cardiomyopathy according to GeneDecks:

(show top 50)    (show all 504)

id	Compound	Score	Top Affiliating Genes
1	ryanodine32	11.8	CKM, QDPR, JPH2, CDH2, ANXA6, CALR
2	nitric oxide32 9 18 9	14.8	PDE3A, REN, GCH1, SERPINA1, VCL, MYD88
3	fatty acid32	11.5	PIK3C2A, MYD88, MT-CO1, INS, MEF2A, FABP3
4	isoproterenol32 9 9	13.3	PDE3A, MYBPC1, CHRM2, CHGA, CDH5, ITGAL
5	nadph32 18	12.0	GCH1, MYD88, QDPR, TXNRD2, CYP2E1
6	threonine32	11.0	SCN5A, CHRM2, MT-ND5, QDPR, MEF2C, IL2RB
7	steroid32	10.9	PIK3C2A, REN, SERPINA3, PAFAH1B1, CKB, CHGA
8	dopamine32 9 18 9	13.9	REN, GCH1, SERPINA3, CHKB, P2RX1, CD40LG
9	phenylephrine32 9 18 9	13.9	MEF2A, CAV3, DYT10, EDNRA, AGT, AGTR1
10	ionomycin32	10.9	SERPINA3, CD70, FOS, IL5, CCL3, CALR
11	atenolol32 9 18 9	13.7	SERPINE1, CYP11B2, ADRB2, ADRB1
12	progesterone32 42 9 18 9	14.6	PCNA, SERPINA3, VCL, CKB, CHGA, CDH2
13	lipid32	10.5	PIK3C2A, SERPINA1, SERPINE1, SERPINA3, VCL, LMNA
14	p00332	10.4	SERPINA1, SERPINE1, CHGA, IL13, IL1RN, IL2RB
15	agar32	10.3	JAK2, CD40LG, CD34, FN1, ILK, GJA1
16	superoxide32 18	11.3	PIK3C2A, GCH1, SERPINA3, CHKB, XDH, ITGAL
17	norepinephrine32 9 18 9	13.3	PIK3C2A, REN, VWF, GCH1, CHRM2, CHGA
18	estradiol32 9 18 9	13.3	REN, PCNA, SERPINE1, SERPINA3, CHKB, CDH5
19	malondialdehyde32	10.3	PIK3C2A, CKM, CHKB, XDH, GSR, FGA
20	ascorbic acid32 18	11.2	PCNA, GCH1, CHKB, JAK2, CD36, CD40LG
21	acth32	10.0	PIK3C2A, REN, SERPINA1, INS, IL1A, IL1RN
22	pge232	9.8	REN, MMP1, MMP3, FN1, GSR, IL13
23	iron32 18	10.8	PIK3C2A, SERPINA1, SERPINA3, MT-CO1, XDH, B2M
24	captopril32 42 9 9	12.8	REN, B2M, MMP2, IL1A, ALB, NR3C2
25	nifedipine32 9 9	11.7	REN, SERPINE1, CHGA, B2M, QDPR, MMP9
26	ifn-alpha32	9.4	IL10, IL13, IL17A, IL18, IL2, IL2RA
27	glutamine32	9.3	VWF, PCNA, VCL, SCN5A, CKB, CHKB
28	chloroquine32 34 9 9	12.3	B2M, ITGAL, GSR, IL10, IL18, IL1RN
29	formaldehyde32 18	10.3	VWF, PCNA, CHGA, SARDH, B2M, CD40LG
30	azathioprine32 34 9 9	12.1	PCNA, CHKB, XDH, ITGAL, MMP2, IL10
31	thalidomide32 42 9 9	12.0	B2M, CD36, CD40LG, IL10, IL18, IL18R1
32	prednisolone32 9 9	11.0	PIK3C2A, VWF, CHKB, ITGAL, MMP1, MMP2
33	gf 109203x32 42	10.0	VCL, JAK2, MMP1, FOS, FN1, MAPK8
34	vitamin b1232	9.0	VWF, PCNA, SERPINA3, B2M, CD40LG, APOE
35	retinoic acid32 42 18	10.8	VWF, SERPINE1, LMNA, MYOCD, CHGA, B2M
36	15-deoxy-delta-12,14-prostaglandin j232	8.7	SERPINE1, JAK2, CD36, FOS, IL10, IL4
37	rantes32	8.6	MYD88, CD70, CD40LG, CD46, ITGAL, MMP1
38	wortmannin32 42	9.5	PIK3C2A, VCL, JAK2, ITGAL, MMP2, MMP9
39	lactate32	8.3	PIK3C2A, VWF, PCNA, CKB, CKM, CHGA
40	alpha tocopherol32	8.1	CKM, CHKB, XDH, CD36, ITGAL, MMP1
41	paraffin32	8.1	VWF, PCNA, SERPINA1, SERPINA3, CHGA, CHKB
42	rosiglitazone32 9 18 9	11.0	SERPINE1, LMNA, JAK2, CD36, MMP1, MMP2
43	aspirin32 34 18	9.9	VWF, PCNA, SERPINE1, CHKB, P2RX1, JAK2
44	estrogen32	7.9	VWF, PCNA, GCH1, SERPINA1, SERPINE1, SERPINA3
45	tamoxifen32 34 9 9	10.6	PCNA, CKB, CHGA, CHKB, FOS, FHL2
46	losartan32 34 9 9	10.6	REN, VWF, PCNA, SERPINE1, XDH, CD36
47	indomethacin32 9 9	9.4	REN, PCNA, B2M, JAK2, CD40LG, MMP1
48	vitamin d32	7.3	SERPINE1, CKB, CHGA, CHKB, B2M, CD36
49	actinomycin d32	7.1	SERPINE1, JAK2, CD40LG, ITGAL, MMP9, FOS
50	genistein32 9 18 9	9.7	PCNA, SERPINE1, B2M, JAK2, CD36, CDH2

Cellular components related to dilated cardiomyopathy according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	Z disc	GO:030018	12.1	ACTN1, TTN, TCAP, DES, CSRP3, NEBL
2	integral to plasma membrane	GO:005887	12.0	SLC6A2, CXADR, PSEN2, PSEN1, TLR4, TLR3
3	sarcolemma	GO:042383	11.8	DAG1, CTSB, DES, SLC2A4, SLC27A6, ADRB2
4	sarcomere	GO:030017	11.6	MYL3, MYL2, MYH7, MYH6, ACTC1, ABCC9
5	I band	GO:031674	11.1	MYL3, NEBL, TTN, ACTC1, ANKRD23, ANKRD2
6	focal adhesion	GO:005925	11.0	MYH7, MYH6, ADAM17, TLN1, ACTN1, ACTN2
7	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	11.0	HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
8	dystrophin-associated glycoprotein complex	GO:016010	10.9	DMD, CAV3, FKRP, SGCD, SGCA, DAG1
9	fascia adherens	GO:005916	10.7	DES, DSP, CTNNA3, GJA1, CDH2, VCL
10	ER to Golgi transport vesicle membrane	GO:012507	10.7	HLA-G, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
11	external side of plasma membrane	GO:009897	10.6	CALR, HLA-DRB1, HLA-DRB4, TNF, PTPRC, CTLA4
12	membrane raft	GO:045121	10.4	PTPRC, DAG1, EDNRA, EGFR, TLR4, CXADR
13	plasma membrane	GO:005886	10.3	HLA-DPA1, DLG5, DAG1, SRC, CTNNAL1, CTLA4
14	cytoskeleton	GO:005856	10.3	NOS3, ACTN2, ACTN1, PRKCE, CSRP3, NEXN
15	protein complex	GO:043234	10.0	PTPN11, DMD, PLN, PSEN2, CXADR, SOD1
16	perinuclear region of cytoplasm	GO:048471	9.9	TLR4, HFE, EGFR, NOS2, CTSB, TF
17	platelet alpha granule lumen	GO:031093	8.9	ACTN2, ACTN1, TGFB1, TGFB2, KNG1, HGF
18	extracellular region	GO:005576	7.3	ALB, PLA2G7, PLAT, PF4, EDN1, ACTN2
19	extracellular space	GO:005615	6.4	REN, SERPINA1, SERPINE1, B2M, CD70, CTSB
20	cytosol	GO:005829	INF	STAT3, MYL3, MYL2, PSEN2, PRKCE, SOCS1

Biological processes related to dilated cardiomyopathy according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle contraction	GO:006936	12.4	UTRN, MYOT, VCL, SGCA, TAZ, TLN1
2	muscle organ development	GO:007517	11.8	IGF1, CAV3, DMD, CTF1, CRYAB, EMD
3	cardiac muscle contraction	GO:060048	11.7	MYL3, GAA, PSEN2, TAZ, TCAP, ACTC1
4	regulation of heart contraction	GO:008016	11.7	GJA1, TPM1, TNNT2, DES, MYH6, HOPX
5	muscle filament sliding	GO:030049	11.6	MYL3, MYL2, MYH7, MYH6, DES, TCAP
6	regulation of the force of heart contraction	GO:002026	11.1	MYL3, MYH6, GAA, CSRP3, PLN, ATP1A1
7	interferon-gamma-mediated signaling pathway	GO:060333	11.1	HLA-DRB1, HLA-DRB4, HLA-G, PTPN11, SOCS1, HLA-DQB1
8	heart development	GO:007507	10.9	PDLIM3, EDN1, EDNRA, TGFB2, TAZ, CXADR
9	regulation of blood pressure	GO:008217	10.9	MYH6, CHGA, GCH1, REN, P2RX1, ATP1A1
10	ventricular cardiac muscle tissue morphogenesis	GO:055010	10.9	MYL3, MYL2, MYH7, MYH6, GAA, TNNT2
11	response to cold	GO:009409	10.8	ADRB1, ADRB3, ADM, ADRB2, SLC27A1, TGFB2
12	response to lipopolysaccharide	GO:032496	10.7	EDN1, EDNRA, TLR4, SOCS1, ADM, ADAM17
13	cytokine-mediated signaling pathway	GO:019221	10.7	HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-G
14	positive regulation of chemokine production	GO:032722	10.7	ADAM17, IL18, IL6, IL6R, TNF, TLR3
15	positive regulation of interleukin-6 production	GO:032755	10.6	TLR4, TLR3, TNF, HSPD1, IL6R, IL6
16	cellular response to mechanical stimulus	GO:071260	10.6	EDNRA, AGT, TLR3, TLR4, TLR8, NFKB1
17	aging	GO:007568	10.6	TGFB2, RTN4, ADM, ADRB3, ADRB1, TGFB1
18	immune response	GO:006955	10.5	HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB4, TNFSF10, CTLA4
19	cell-cell signaling	GO:007267	10.5	CTF1, LTA, EDN1, AGT, TGFB2, ADAM10
20	positive regulation of cardiac muscle hypertrophy	GO:010613	10.5	MTPN, IL6ST, IGF1, CAMK2D, EDN1, AGT
21	positive regulation of inflammatory response	GO:050729	10.4	AGT, AGTR1, TLR3, TLR4, TGM2, EDNRA
22	positive regulation of tumor necrosis factor production	GO:032760	10.4	TLR3, PF4, CCL3, IL18, CD36, JAK2
23	regulation of sensory perception of pain	GO:051930	10.3	ADRB2, RTN4, TLR4, EDN1, CCL3, IL1A
24	positive regulation of interferon-gamma production	GO:032729	10.2	TLR4, LTA, TNF, HSPD1, IL23R, IL2
25	cell adhesion	GO:007155	10.2	CTNNAL1, SPP1, SRC, TNC, F5, CTNNB1
26	wound healing	GO:042060	10.1	ADRB1, ADRB2, TGFB2, DSP, PPARA, TPM1
27	cellular response to lipopolysaccharide	GO:071222	10.1	TLR4, NFKBIL1, NOS2, SERPINE1, CD36, MEF2C
28	response to hypoxia	GO:001666	10.1	ADIPOQ, PLAT, CRYAB, CRP, PPARA, TNF
29	response to ethanol	GO:045471	9.9	STAT3, SOD1, NPPC, SLC2A4, ADIPOQ, TLR4
30	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.9	IL2, IL23R, IL4, IGF1, GH1, CSF2
31	negative regulation of cell proliferation	GO:008285	9.8	DLG5, SST, CTNNB1, NOS3, AGT, TGFB1
32	positive regulation of apoptotic process	GO:043065	9.7	NOS3, AGT, TLR3, TLR4, TGFB2, SOD1
33	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	PRKCE, TGFB1, TLR4, NOS3, TNF, CCL3
34	inflammatory response	GO:006954	9.6	NFKB1, CRP, SPP1, TNFRSF1B, TNF, TLR3
35	nerve growth factor receptor signaling pathway	GO:048011	9.6	STAT3, PSEN1, PSEN2, PRKCE, RTN4, ADORA2A
36	acute-phase response	GO:006953	9.6	STAT3, CRP, F2, IL6R, IL6, IL1RN
37	induction of apoptosis	GO:006917	9.6	LTA, AGT, TGFB1, TGFB2, TGM2, DFFB
38	positive regulation of MAPK cascade	GO:043410	9.5	ADRB3, ADRB2, PRKCE, AGT, PTPRC, IGF1
39	response to estradiol stimulus	GO:032355	9.5	SOCS1, STAT3, TGFB2, TGFB1, NOS3, CRYAB
40	anti-apoptosis	GO:006916	9.4	HSPA1B, GHRL, TNF, CRYAB, NOS3, NFKB1
41	response to drug	GO:042493	9.4	CALR, PDE3A, REN, LOX, CCL2, FAS
42	positive regulation of cell proliferation	GO:008284	9.3	EDNRA, EGFR, TGFB1, TGFB2, CSF2, ADAM10
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	TP53, AGT, TLR4, ADIPOQ, HGF, GH1
44	platelet degranulation	GO:002576	9.1	PF4, ALB, F5, IGF1, FGA, FN1
45	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.1	HGF, TGFB2, AGT, GH1, CAT, F2
46	signal transduction	GO:007165	8.7	NR3C2, PPARG, SRC, DLG5, TNFSF10, TNFRSF11B
47	platelet activation	GO:030168	8.1	ACTN2, PF4, SRC, ALB, F2, F5
48	negative regulation of apoptotic process	GO:043066	7.9	GHRL, TP53, TNF, PF4, EDNRA, EGFR
49	blood coagulation	GO:007596	7.7	ADORA2A, ADRA2C, KNG1, SOD1, CXADR, PRKCE
50	apoptotic process	GO:006915	INF	ACTC1, NFKB1, CTNNB1, DIABLO, TNFSF10, TNFRSF1B

Molecular functions related to dilated cardiomyopathy according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of muscle	GO:008307	12.0	MYL3, MYOT, MYBPC2, MYBPC1, MYBPC3, ANKRD2
2	actin binding	GO:003779	11.3	TNNI3, TNNT2, DMD, DAG1, ACE, ACTN1
3	titin binding	GO:031432	11.1	TCAP, ACTN2, ANKRD23, ANKRD2, ANKRD1, MYBPC1
4	ion channel binding	GO:044325	10.5	ACTN1, ACTN2, ABCC9, CTNNB1, SRC, TRDN
5	NADP binding	GO:050661	10.2	G6PD, NOS3, NOS2, TXNRD2, CAT, ME1
6	protein homodimerization activity	GO:042803	10.2	SOD1, TGFB2, TGFB1, G6PD, NFKB1, NOS2
7	receptor binding	GO:005102	10.1	ADIPOQ, ADM, ADAM10, C3, KNG1, NPY
8	cytokine activity	GO:005125	9.8	TNFRSF11B, TNFSF10, SPP1, CTF1, LTA, EDN1
9	hormone activity	GO:005179	9.8	NPPA, NPPB, NPPC, ADM, ADIPOQ, AGT
10	protease binding	GO:002020	9.5	POLG, TTN, TNF, TP53, HSPA1B, INS
11	chaperone binding	GO:051087	9.0	CP, SOD1, TP53, CALR, HSPD1, ALB
12	protein binding	GO:005515	8.5	HADHA, NEBL, RTN4, SLC25A4, SLC25A5, SLC2A4