DCM
MCID: DLT002
MIFTS: 74

Dilated Cardiomyopathy (DCM) malady

Cardiovascular category

Summaries for Dilated Cardiomyopathy

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Dilated cardiomyopathy is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. it is the most common type of cardiomyopathy and typically affects those aged 20 to 60. the left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. the heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. over time, the heart becomes weaker and heart failure can occur. while the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired or inherited. last updated: 9/29/2011

MalaCards: Dilated Cardiomyopathy, also known as primary dilated cardiomyopathy, is related to hypertrophic cardiomyopathy and dmd-associated dilated cardiomyopathy. An important gene associated with Dilated Cardiomyopathy is VCL (vinculin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoskeletal Signaling. The drugs inamrinone and inamrinone lactate and the compounds lipid and calcium have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and mortality/aging.

Disease Ontology:8 An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart.

Wikipedia:64 Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot... more...

Description from OMIM:47 604145, 613642, 613252, 609909, 613286 613881, 613172, 607487, 613122, 613697, 300069, 611407, 605362, 613426, 606685, 601493, 608569, 611615, 611878, 613740, 601154, 604765, 612877, 613424, 302045, 613694, 611880, 607482, 612158, 614672, 611879, 115200, 601494 more

GeneReviews summary for dcm-ov

Aliases & Classifications for Dilated Cardiomyopathy

Sources:
8Disease Ontology, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 39NCBI Bookshelf, 31LifeMap Discovery™, 61UMLS, 47OMIM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

dilated cardiomyopathy 8 19 43 20 10 45 31
primary dilated cardiomyopathy 8 22
dcm 43 39
cardiomyopathy, familial idiopathic 61
idiopathic dilated cardiomyopathy 43
cardiomyopathy, congestive 8
cardiomyopathy, dilated 61
diastrophic dysplasia 61
diastrophic dwarfism 19


Related Diseases for Dilated Cardiomyopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Dilated Cardiomyopathy family:

dilated cardiomyopathy with hypergonadotropic hypogonadism cardiomyopathy dilated with conduction defect type 1
cardiomyopathy dilated with conduction defect type 2 cardiomyopathy dilated with woolly hair and keratoderma
cardiomyopathy due to anthracyclines familial dilated cardiomyopathy
cardiomyopathy with or without skeletal myopathy dilated cardiomyopathy with quadriceps myopathy
des-related dilated cardiomyopathy cardiomyopathy, dilated, 1ll
cardiomyopathy, dilated, 1cc cardiomyopathy, dilated, 1a
cardiomyopathy, dilated, 1v cardiomyopathy, dilated, 1d
cardiomyopathy, dilated, 1aa cardiomyopathy, dilated, 1h
cardiomyopathy, dilated, 1g cardiomyopathy, dilated, 1i
cardiomyopathy, dilated, 1z cardiomyopathy, dilated, 1e
cardiomyopathy, dilated, 1gg cardiomyopathy, dilated, 1l
cardiomyopathy, dilated, 1k cardiomyopathy, dilated, 1jj
cardiomyopathy, dilated, 1p cardiomyopathy, dilated, 1j
cardiomyopathy, dilated, 2b cardiomyopathy, dilated, 1q
cardiomyopathy, dilated 1b cardiomyopathy, dilated, 1x
cardiomyopathy, dilated, 1kk cardiomyopathy, dilated, 1w
cardiomyopathy, dilated 1c cardiomyopathy, dilated, 1dd
cardiomyopathy, dilated, 1hh cardiomyopathy, dilated, 1m
cardiomyopathy, dilated, 1mm cardiomyopathy, dilated, 1ii
cardiomyopathy, dilated, 1o cardiomyopathy, dilated, 1t
cardiomyopathy, dilated, 1ee cardiomyopathy, dilated, 1s
cardiomyopathy, dilated, 1u cardiomyopathy, dilated, 1r
cardiomyopathy, dilated, 1n cardiomyopathy, dilated, 1bb
cardiomyopathy, dilated, 2a cardiomyopathy, dilated, 1ff

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 289)
idRelated DiseaseScoreTop Affiliating Genes
1hypertrophic cardiomyopathy31.1ACTC1, MYH7, TNNT2, CSRP3
2dmd-associated dilated cardiomyopathy30.8DMD, TAZ
3endocardial fibroelastosis30.6TAZ
4becker muscular dystrophy30.6DMD
5duchenne muscular dystrophy30.4DMD
6nemaline myopathy30.4ACTC1
7emery-dreifuss muscular dystrophy30.3TMPO, LMNA, DMD
8familial hypertrophic cardiomyopathy30.2CSRP3, TNNT2, MYH7, PLN, ACTC1
9barth syndrome30.2DNAJC19, TAZ, LDB3
10limb-girdle muscular dystrophy29.9LMNA, FKTN, DMD
11sudden cardiac death multi-gene panels29.9LMNA, MYH7, TNNT2
12fukuyama type muscular dystrophy29.9DMD, FKTN
13myopathy congenital29.9DMD, MYH7
14familial dilated cardiomyopathy11.1
15mitochondrial cardiomyopathy10.6
16stress cardiomyopathy10.6
17dwarfism10.5
18acute myocarditis10.5
19atelosteogenesis10.5
20chondrodysplasia10.5
21diastrophic dysplasia10.4
22wolff-parkinson-white syndrome10.4
23rickets10.4
24peripartum cardiomyopathy10.4
25autoimmune myocarditis10.4
26cardiomyopathy, dilated, 1a10.4
27chagas disease10.4
28n syndrome10.4
29cardiomyopathy dilated with woolly hair and keratoderma10.4
30diastrophic dysplasia, broad bone-platyspondylic variant10.4
31atrioventricular block10.3
32cushing's syndrome10.3
33lmna-related dilated cardiomyopathy10.3
34coronary artery disease,10.3
35conduct disorder10.3
36doxorubicin induced cardiomyopathy10.3
37left ventricular noncompaction10.3
38keratoderma10.3
39cardiomyopathy, dilated, 1j10.3
40multiple epiphyseal dysplasia10.3
41otosclerosis10.3
42pseudoachondroplasia10.3
43achondrogenesis10.3
44multiple epiphyseal dysplasia, recessive10.3
45hepatitis c10.2
46sensorineural hearing loss10.2
47cardiac sarcoidosis10.2
48hypoparathyroidism10.2
49celiac disease10.2
50hepatitis d10.2

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to dilated cardiomyopathy

Clinical Features for Dilated Cardiomyopathy

Sources:
47OMIM
See all sources

Drugs & Therapeutics for Dilated Cardiomyopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dilated Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Dilated Cardiomyopathy

Search NIH Clinical Center for Dilated Cardiomyopathy

Search CenterWatch for Dilated Cardiomyopathy

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.

Genetic Tests for Dilated Cardiomyopathy

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Dilated Cardiomyopathy20 VCL
2 Primary Dilated Cardiomyopathy22

Anatomical Context for Dilated Cardiomyopathy

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
id TissueAnatomical CompartmentCell Relevance
1 HeartMyocardiumCardiomyocytes Affected by disease
2 HeartLeft VentricleCardiomyocytes Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Dilated Cardiomyopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536911.9LDB3, PDCD1, CSRP3, TNNT2, DMD, FKTN
2MP:001076811.8DMD, TNNT2, CSRP3, PDCD1, EYA4, FKTN
3MP:000538511.7DMD, TNNT2, CSRP3, PDCD1, PLN, LMNA
4MP:000537811.6CSRP3, TNNT2, DMD, FKTN, LMNA, ACTC1
5MP:000538110.9EYA4, DMD, LMNA, VCL, TMPO, LDB3

Publications for Dilated Cardiomyopathy

Sources:
51PubMed
See all sources

Articles related to Dilated Cardiomyopathy:

(show top 50)    (show all 1331)
idTitleAuthorsYear
1
A novel GATA4 loss-of-function mutation responsible for familial dilated cardiomyopathy. (24366163)
2014
2
Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy. (24119082)
2013
3
Immunoadsorption therapy for dilated cardiomyopathy and pulmonary arterial hypertension. (23357166)
2013
4
Ischemic versus nonischemic dilated cardiomyopathy: the implications of heart failure etiology on left ventricular assist device outcomes. (23438774)
2013
5
Myocardial 123I-MIBG scintigraphy predicts an impairment in myocardial functional reserve during dobutamine stress in patients with idiopathic dilated cardiomyopathy. (23096078)
2013
6
Structural alterations of Lamin A protein in dilated cardiomyopathy. (23701190)
2013
7
Monocyte chemotactic protein-1 promotes the myocardial homing of mesenchymal stem cells in dilated cardiomyopathy. (23591836)
2013
8
Simulation of left ventricle flow dynamics with dilated cardiomyopathy during the filling phase. (23367367)
2012
9
Combined spinal-epidural anesthesia for cesarean section in a patient with dilated cardiomyopathy. (22557770)
2012
10
Idiopathic dilated cardiomyopathy: possible triggers and treatment strategies. (22618228)
2012
11
Serum carbohydrate antigen 125 levels in nonischemic dilated cardiomyopathy: a useful biomarker for prognosis and functional mitral regurgitation. (22587744)
2012
12
Abnormal p38I+ mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation. (22773734)
2012
13
Idiopathic dilated cardiomyopathy and persistent viral infection: lack of association in a controlled study using a quantitative assay. (22901461)
2012
14
Preserved cardiomyocyte function and altered desmin pattern in transgenic mouse model of dilated cardiomyopathy. (22285482)
2012
15
Familial dilated cardiomyopathy. (21574539)
2011
16
Cellular proliferative response to cardiac troponin-I in patients with idiopathic dilated cardiomyopathy. (22029801)
2011
17
Images in cardiology. Chloroquine-induced transition from dilated to restrictive cardiomyopathy. (21251591)
2011
18
Dilated alcoholic cardiomyopathy and incidental lymphoma occuring in a 56 year old man who was being managed for hypertensive heart disease in Enugu Nigeria--a rare finding. (22288332)
2011
19
RE: Sheehan syndrome with reversible dilated cardiomyopathy. (21060164)
2010
20
Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy. (20117437)
2010
21
Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. (20951326)
2010
22
Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy. (20488170)
2010
23
Sheehan syndrome with reversible dilated cardiomyopathy. (20622352)
2010
24
Fcgamma-receptor IIa polymorphism and the role of immunoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy. (20054293)
2010
25
Endocardial fibroelastosis in dilated cardiomyopathy in a 28-year-old transplant recipient. (18826986)
2009
26
Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report]. (19169978)
2008
27
Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data. (18796670)
2008
28
Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: a preliminary study. (17400681)
2007
29
Comparison of regional systolic myocardial velocities in patients with isolated left ventricular noncompaction and patients with idiopathic dilated cardiomyopathy. (17543758)
2007
30
Cardiac PPARalpha expression in patients with dilated cardiomyopathy. (16307905)
2006
31
Is the ApoE polymorphism associated with dilated cardiomyopathy? (16714771)
2006
32
Endotoxin-independent white cell cytokine production in haemodynamically stable patients with idiopathic dilated cardiomyopathy. (16307158)
2005
33
TNF-related apoptosis-inducing ligand and its decoy receptor osteoprotegerin in nonischemic dilated cardiomyopathy. (16288714)
2005
34
Gene symbol: LMNA. Disease: cardiomyopathy, dilated, with conduction defect 1. (16156025)
2005
35
Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene. (15769782)
2005
36
Predictors of left ventricular thrombus formation in patients with dilated cardiomyopathy: role of activated protein C resistance. (15024298)
2004
37
Relationship between HLA-DQA1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy. (15498363)
2004
38
Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy. (12485814)
2003
39
Familial dilated cardiomyopathy. (12621922)
2002
40
Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia. (12380923)
2002
41
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
42
The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review. (11302994)
2001
43
Effects of growth hormone on cardiac dysfunction and gene expression in genetic murine dilated cardiomyopathy. (11192363)
2000
44
Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: the CARDIGENE study. (10636255)
2000
45
Does angiotensin-converting enzyme polymorphism influence the clinical manifestation and progression of heart failure in patients with dilated cardiomyopathy? (10072245)
1999
46
Familial dilated cardiomyopathy. (10534480)
1999
47
Quantitative evaluation of left ventricular function in a TransgenicMouse model of dilated cardiomyopathy with 2-dimensional contrast echocardiography. (10070185)
1999
48
Comparison of changes in respiratory function and exercise oxygen uptake with losartan versus enalapril in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. (9416938)
1997
49
Protein-energy malnutrition in patients with ischemic and nonischemic dilated cardiomyopathy and congestive heart failure. (8184823)
1994
50
A familial dilated cardiomyopathy associated with cataracts and hip-spine disease. (3965265)
1985

Genetic Variations for Dilated Cardiomyopathy

Expression for genes affiliated with Dilated Cardiomyopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dilated Cardiomyopathy

Search GEO for disease gene expression data for Dilated Cardiomyopathy.

Pathways for genes affiliated with Dilated Cardiomyopathy

Sources:
30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 54Reactome
See all sources

Compounds for genes affiliated with Dilated Cardiomyopathy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipid4511.2MYH7, TAZ, PLN, LMNA, VCL, DMD
2calcium45 50 11 2414.1TNNT2, DMD, MYH7, PLN, LMNA, ACTC1
3creatinine4511.1ACTC1, LMNA, MYH7, DMD, TNNT2
4alpha-bungarotoxin45 6011.6DMD, TMPO

GO Terms for genes affiliated with Dilated Cardiomyopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Z discGO:03001811.3LDB3, VCL, MYH7, NEXN, DMD, CSRP3
2cytoskeletonGO:00585611.2CSRP3, NEXN, SGCD, VCL, LDB3
3sarcomereGO:03001710.8ACTC1, MYH7, TNNT2
4cell-substrate junctionGO:03005510.8DMD, VCL
5sarcolemmaGO:04238310.7DMD, SGCD, VCL
6costamereGO:04303410.7VCL, DMD
7dystrophin-associated glycoprotein complexGO:01601010.4SGCD, DMD

Biological processes related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004911.2ACTC1, MYH7, DMD, TNNT2
2cardiac muscle contractionGO:06004811.2ACTC1, TAZ, DMD, CSRP3
3muscle organ developmentGO:00751711.2SGCD, LMNA, FKTN, DMD
4cardiac muscle tissue developmentGO:04873811.1CSRP3, TAZ, PLN
5ATP catabolic processGO:00620011.0TNNT2, MYH7, ACTC1
6muscle contractionGO:00693611.0VCL, TAZ, MYH7
7negative regulation of ATPase activityGO:03278010.9PLN, TNNT2
8cardiac myofibril assemblyGO:05500310.9ACTC1, CSRP3
9regulation of ryanodine-sensitive calcium-release channel activityGO:06031410.8PLN, DMD
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:01088110.7DMD, PLN
11regulation of heart rateGO:00202710.7MYH7, DMD
12regulation of the force of heart contractionGO:00202610.6PLN, CSRP3
13sarcomere organizationGO:04521410.4LDB3, TNNT2

Molecular functions related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:00830711.0MYH7, NEXN, DMD, CSRP3
2actin bindingGO:00377910.9TNNT2, DMD, MYH7, VCL
3dystroglycan bindingGO:00216210.7VCL, DMD
4myosin bindingGO:01702210.7ACTC1, DMD
5ATPase activityGO:01688710.5ACTC1, MYH7, TNNT2

Products for genes affiliated with Dilated Cardiomyopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dilated Cardiomyopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet