DCM
MCID: DLT002
MIFTS: 82

Dilated Cardiomyopathy (DCM) malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Muscle diseases, Ear diseases, Neuronal diseases categories
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Summaries for Dilated Cardiomyopathy

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Dilated cardiomyopathy is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. it is the most common type of cardiomyopathy and typically affects those aged 20 to 60. the left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. the heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. over time, the heart becomes weaker and heart failure can occur. while the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired or inherited. last updated: 9/29/2011

MalaCards: Dilated Cardiomyopathy, also known as primary dilated cardiomyopathy, is related to congestive heart failure and muscular dystrophy. An important gene associated with Dilated Cardiomyopathy is VCL (vinculin), and among its related pathways are Nuclear Envelope Reassembly and Striated Muscle Contraction. The drugs inamrinone and inamrinone lactate and the compounds actomyosin and creatinine have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and lung, and related mouse phenotypes are homeostasis/metabolism and growth/size/body.

Disease Ontology:8 An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart.

Wikipedia:65 Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot... more...

Description from OMIM:47 613694, 614672, 613881, 613642, 612158 612877, 300069, 611880, 601154, 607482, 302045, 608569, 611407, 613697, 611879, 601494, 609909, 605362, 604145, 606685, 601493, 613172, 613122, 613426, 604765, 611878, 613740, 613286, 613424, 115200, 613252, 607487, 611615 more

GeneReviews summary for dcm-ov

Aliases & Classifications for Dilated Cardiomyopathy

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Sources:
8Disease Ontology, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 39NCBI Bookshelf, 31LifeMap Discoveryâ„¢, 62UMLS, 47OMIM, 58SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

dilated cardiomyopathy 8 19 43 20 10 45 31
primary dilated cardiomyopathy 8 22
dcm 43 39
cardiomyopathy, familial idiopathic 62
idiopathic dilated cardiomyopathy 43
cardiomyopathy, congestive 8
cardiomyopathy, dilated 62
diastrophic dysplasia 62


Related Diseases for Dilated Cardiomyopathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Dilated Cardiomyopathy family:

Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines
Familial Dilated Cardiomyopathy Taz-Related Dilated Cardiomyopathy
Tnnt2-Related Dilated Cardiomyopathy Myh7-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Tpm1-Related Dilated Cardiomyopathy
Des-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Ldb3-Related Dilated Cardiomyopathy Pln-Related Dilated Cardiomyopathy
Scn5a-Related Dilated Cardiomyopathy Dmd-Related Dilated Cardiomyopathy
Ttn-Related Dilated Cardiomyopathy Csrp3-Related Dilated Cardiomyopathy
Tcap-Related Dilated Cardiomyopathy Abcc9-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy Actn2-Related Dilated Cardiomyopathy
Tnnc1-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Psen2-Related Dilated Cardiomyopathy Psen1-Related Dilated Cardiomyopathy
Eya4-Related Dilated Cardiomyopathy Tmpo-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Dsg2-Related Dilated Cardiomyopathy
Nexn-Related Dilated Cardiomyopathy Rbm20-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1ll Cardiomyopathy, Dilated, 1cc
Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1aa
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 1e Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1jj Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated 1b
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1kk
Cardiomyopathy, Dilated, 1w Cardiomyopathy, Dilated 1c
Cardiomyopathy, Dilated, 1dd Cardiomyopathy, Dilated, 1hh
Cardiomyopathy, Dilated, 1m Cardiomyopathy, Dilated, 1mm
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1o
Cardiomyopathy, Dilated, 1t Cardiomyopathy, Dilated, 1ee
Cardiomyopathy, Dilated, 1s Cardiomyopathy, Dilated, 1u
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1n
Cardiomyopathy, Dilated, 1bb Cardiomyopathy, Dilated, 2a
Cardiomyopathy, Dilated, 1ff

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.1TNNT2
2muscular dystrophy31.0FKTN, LMNA, SGCD
3hypertrophic cardiomyopathy30.9MYH7, ACTC1, TNNT2, CSRP3
4endocardial fibroelastosis30.9TAZ
5myopathy30.8LMNA, FKTN, LDB3, TAZ, TNNT2, MYH7
6becker muscular dystrophy30.6FKTN, VCL
7coronary artery disease30.5TNNT2, LMNA, LDB3
8atrioventricular block30.5LMNA, SCN5A
9emery-dreifuss muscular dystrophy30.5LMNA, TMPO
10duchenne muscular dystrophy30.4VCL, SGCD, TNNT2, FKTN
11long qt syndrome30.4MYH7, SCN5A
12barth syndrome30.3LDB3, TAZ, DNAJC19
13neuropathy30.3SGCD, LMNA, FKTN
14ischemia30.2MYH7, VCL, SCN5A, TNNT2
15familial hypertrophic cardiomyopathy30.0TNNT2, MYH7, ACTC1, CSRP3, PLN
16limb-girdle muscular dystrophy30.0FKTN, LMNA
17familial dilated cardiomyopathy11.0
18myocarditis10.9
19dmd-associated dilated cardiomyopathy10.6
20dilated cardiomyopathy with ataxia syndrome10.5
21acute myocarditis10.5
22hypertension10.5
23rickets10.4
24peripartum cardiomyopathy10.4
25wolff-parkinson-white syndrome10.4
26autoimmune myocarditis10.4
27cardiomyopathy dilated with woolly hair and keratoderma10.4
28cardiomyopathy, dilated, 1a10.4
29cushing's syndrome10.3
30chagas disease10.3
31epidermolysis bullosa10.3
32hepatitis10.3
33lmna-related dilated cardiomyopathy10.3
34conduct disorder10.3
35nemaline myopathy10.3
36artery disease10.3
37left ventricular noncompaction10.3
38keratoderma10.3
39cardiomyopathy, dilated, 1j10.3
40cardiomyopathy, dilated, 1w10.3
41endotheliitis10.3
42hepatitis c10.2
43celiac disease10.2
44cocaine abuse10.2
45sensorineural hearing loss10.2
46chorea-acanthocytosis10.2
47amyloidosis10.2
48myocardial infarction10.2
49obesity10.2
50pheochromocytoma10.2

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to dilated cardiomyopathy

Symptoms for Dilated Cardiomyopathy

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Sources:
47OMIM
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Drugs & Therapeutics for Dilated Cardiomyopathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discoveryâ„¢, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Dilated Cardiomyopathy

Search NIH Clinical Center for Dilated Cardiomyopathy

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.

Genetic Tests for Dilated Cardiomyopathy

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20GeneTests, 22GTR
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Genetic tests related to Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Dilated Cardiomyopathy20 VCL
2 Primary Dilated Cardiomyopathy22

Anatomical Context for Dilated Cardiomyopathy

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31LifeMap Discoveryâ„¢, 33MalaCards
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MalaCards organs/tissues related to Dilated Cardiomyopathy:

33
Heart, Bone, Lung, Liver, Monocytes, Testes, Brain, Skeletal muscle, T cells, Endothelial, Bone marrow, Kidney, Thyroid, Spleen, Whole blood, B cells, Eye, Cardiac myocytes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
id TissueAnatomical CompartmentCell Relevance
1 HeartMyocardiumCardiomyocytes Affected by disease
2 HeartLeft VentricleCardiomyocytes Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Dilated Cardiomyopathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.5SGCD, LMNA, FKTN, LDB3, ACTC1, PLN
2MP:00053787.4TNNT2, SCN5A, EYA4, LMNA, VCL, FKTN
3MP:00053857.2LMNA, SGCD, SCN5A, TNNT2, VCL, LDB3
4MP:00053696.9PDCD1, TNNT2, SCN5A, SGCD, LMNA, VCL
5MP:00107686.4LMNA, EYA4, SGCD, SCN5A, TNNT2, VCL

Publications for Dilated Cardiomyopathy

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52PubMed
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Articles related to Dilated Cardiomyopathy:

(show top 50)    (show all 1303)
idTitleAuthorsYear
1
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
2
Sphericity Index and E-Point-to-Septal-Separation (EPSS) to Diagnose Dilated Cardiomyopathy in Doberman Pinschers. (24428318)
2014
3
Cerebral infarction in both carotid and vertebrobasilar territories associated with a persistent primitive hypoglossal artery with severe dilated cardiomyopathy. (22959108)
2014
4
Anticoagulation in patients with dilated cardiomyopathy, low ejection fraction, and sinus rhythm: back to the drawing board. (23279759)
2013
5
Prediction of improvement in cardiac function by high dose dobutamine stress echocardiography in patients with recent onset idiopathic dilated cardiomyopathy. (23312406)
2013
6
Response to letters regarding article, "Myocardial fibrosis as a key determinant of left ventricular remodeling in idiopathic dilated cardiomyopathy: a contrast-enhanced cardiovascular magnetic study". (24254489)
2013
7
Follow-up of the patients after stem cell transplantation for pediatric dilated cardiomyopathy. (23458132)
2013
8
Fibrosis and mortality in patients with dilated cardiomyopathy. (23800925)
2013
9
A1180V of cardiac sodium channel gene (SCN5A): is it a risk factor for dilated cardiomyopathy or just a common variant in Han Chinese? (24227891)
2013
10
Prognostic value of left atrial volume in patients with dilated cardiomyopathy. (24119867)
2013
11
Prognostic value of late gadolinium enhancement in dilated cardiomyopathy patients. A meta-analysis. (23860892)
2013
12
QRS prolongation is strongly associated with life-threatening ventricular arrhythmias in children with dilated cardiomyopathy. (23932443)
2013
13
Autoimmunity against Ma88muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. (22328321)
2012
14
Human leukocyte antigen-DQ beta 1 chain (DQB1) gene polymorphisms are associated with dilated cardiomyopathy: a systematic review and meta-analysis. (22386792)
2012
15
Mitral valve surgery for severe mitral regurgitation and dilated cardiomyopathy--a bridge to transplant: case report and a review of literature. (22309207)
2012
16
Clinical and functional capacity of patients with dilated cardiomyopathy after four years of transplantation. (23515729)
2012
17
SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism. (21596231)
2011
18
Familial dilated cardiomyopathy. (21574539)
2011
19
A novel custom resequencing array for dilated cardiomyopathy. (20474083)
2010
20
Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy. (19480714)
2009
21
Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure. (19944367)
2009
22
Polymorphisms of the beta-1 and beta-2 adrenergic receptors in Polish patients with idiopathic dilated cardiomyopathy. (19378229)
2009
23
Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. (18940188)
2009
24
Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes. (19324307)
2009
25
ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy. (18165925)
2008
26
Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. (17987279)
2008
27
Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report]. (19169978)
2008
28
Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy. (17292982)
2008
29
Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. (17620508)
2007
30
Dilated cardiomyopathy and adipic aciduria in nutritional rickets. (16628102)
2006
31
Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies? (17204908)
2006
32
Content of myosin-activating protein kinases in myocardium of patients with dilated cardiomyopathy and in the animal heart]. (17131835)
2006
33
Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. (16387818)
2006
34
The influence of aetiology on inflammatory and neurohumoral activation in patients with severe heart failure: a prospective study comparing Chagas' heart disease and idiopathic dilated cardiomyopathy. (16043406)
2005
35
HLA-DQA1, -DQB1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy in Hans of northern China. (15996167)
2005
36
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. (15034580)
2004
37
Metavinculin mutations alter actin interaction in dilated cardiomyopathy. (11815424)
2002
38
Familial dilated cardiomyopathy. (12621922)
2002
39
Usefulness of cardiac transplantation in children with visceral heterotaxy (asplenic and polysplenic syndromes and single right-sided spleen with levocardia) and comparison of results with cardiac transplantation in children with dilated cardiomyopathy. (12031727)
2002
40
Mutations in the dystrophin gene are associated with sporadic dilated cardiomyopathy. (12359139)
2002
41
Case of AlstrAPm syndrome with late presentation dilated cardiomyopathy. (11767878)
2001
42
A case of chorea-acanthocytosis with dilated cardiomyopathy and myopathy]. (11218703)
2000
43
Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy. (11140941)
2000
44
Mitochondrial respiratory chain activity in idiopathic dilated cardiomyopathy. (10746819)
2000
45
Advances in molecular genetics of dilated cardiomyopathy. The Heart Muscle Disease Study Group. (9891591)
1998
46
Reduction of myocardial myoglobin in bovine dilated cardiomyopathy. (9140831)
1997
47
Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A. (9386183)
1997
48
Evidence that polymorphism of the angiotensin I converting enzyme gene may be related to idiopathic dilated cardiomyopathy in the Chinese population. (7492954)
1995
49
Dilated cardiomyopathy and the dystrophin gene: an illustrated review. (7833192)
1994
50
Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy. (8252591)
1993

Variations for Dilated Cardiomyopathy

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Dilated Cardiomyopathy:

1 (show all 36)
id Gene Name Type Significance SNP ID Assembly Location
1TNNT2NM_000364.3(TNNT2): c.421C> T (p.Arg141Trp)single nucleotide variantLikely pathogenic, Pathogenic, Uncertain significancers74315380GRCh37Chr 1, 201333494: 201333494
2LMNANM_005572.3(LMNA): c.16C> T (p.Gln6Ter)single nucleotide variantPathogenicrs61046466GRCh37Chr 1, 156084725: 156084725
3LMNANM_005572.3(LMNA): c.1445G> A (p.Arg482Gln)single nucleotide variantPathogenicrs11575937GRCh37Chr 1, 156106776: 156106776
4LMNANM_005572.3(LMNA): c.481G> A (p.Glu161Lys)single nucleotide variantPathogenicrs28933093GRCh37Chr 1, 156100532: 156100532
5RBM20NM_001134363.2(RBM20): c.1913C> T (p.Pro638Leu)single nucleotide variantPathogenicrs267607003GRCh37Chr 10, 112572068: 112572068
6RBM20NM_001134363.2(RBM20): c.1906C> A (p.Arg636Ser)single nucleotide variantLikely pathogenic, Pathogenicrs267607002GRCh37Chr 10, 112572061: 112572061
7RBM20NM_001134363.2(RBM20): c.1907G> A (p.Arg636His)single nucleotide variantLikely pathogenic, Pathogenicrs267607004GRCh37Chr 10, 112572062: 112572062
8BAG3NM_004281.3(BAG3): c.367C> T (p.Arg123Ter)single nucleotide variantLikely pathogenic, Pathogenicrs387906875GRCh37Chr 10, 121429549: 121429549
9TPM1NM_001018005.1(TPM1): c.688G> A (p.Asp230Asn)single nucleotide variantPathogenicrs199476317GRCh37Chr 15, 63354462: 63354462
10SCN5ANM_000335.4(SCN5A): c.665G> A (p.Arg222Gln)single nucleotide variantLikely pathogenic, Pathogenicrs45546039GRCh37Chr 3, 38655272: 38655272
11SLC26A2NM_000112.3(SLC26A2): c.835C> T (p.Arg279Trp)single nucleotide variantPathogenicrs104893915GRCh37Chr 5, 149359991: 149359991
12SLC26A2NM_000112.3(SLC26A2): c.532C> T (p.Arg178Ter)single nucleotide variantPathogenicrs104893919GRCh37Chr 5, 149357747: 149357747
13SLC26A2NM_000112.3(SLC26A2): c.1273A> G (p.Asn425Asp)single nucleotide variantPathogenicrs104893920GRCh37Chr 5, 149360429: 149360429
14SLC26A2NM_000112.3(SLC26A2): c.2033G> T (p.Gly678Val)single nucleotide variantPathogenicrs104893916GRCh37Chr 5, 149361189: 149361189
15SLC26A2NM_000112.3(SLC26A2): c.1361A> C (p.Gln454Pro)single nucleotide variantPathogenicrs104893921GRCh37Chr 5, 149360517: 149360517
16SLC26A2NM_000112.3(SLC26A2): c.1957T> A (p.Cys653Ser)single nucleotide variantPathogenicrs104893924GRCh37Chr 5, 149361113: 149361113
17SLC26A2NM_000112.3(SLC26A2): c.1535C> A (p.Thr512Lys)single nucleotide variantPathogenicrs121908078GRCh37Chr 5, 149360691: 149360691
18SLC26A2NM_000112.3(SLC26A2): c.398C> T (p.Ala133Val)single nucleotide variantPathogenicrs267607055GRCh37Chr 5, 149357613: 149357613
19TAZNM_000116.3(TAZ): c.718G> C (p.Gly240Arg)single nucleotide variantPathogenicrs387907218GRCh37Chr X, 153649015: 153649015
20MYH7NM_000257.3(MYH7): c.4522_4524delGAG (p.Glu1508del)deletionLikely pathogenic, Pathogenicrs397516220GRCh37Chr 14, 23886197: 23886199
21MYH7NM_000257.3(MYH7): c.5401G> A (p.Glu1801Lys)single nucleotide variantLikely pathogenic, Pathogenicrs397516248GRCh37Chr 14, 23884362: 23884362
22MYH7NM_000257.3(MYH7): c.5740G> A (p.Glu1914Lys)single nucleotide variantLikely pathogenic, Pathogenicrs397516254GRCh37Chr 14, 23883018: 23883018
23TNNT2NM_000364.3(TNNT2): c.650_652delAGA (p.Lys217del)deletionPathogenicrs45578238GRCh37Chr 1, 201331099: 201331101
24DESNM_001927.3(DES): c.38C> T (p.Ser13Phe)single nucleotide variantPathogenicrs62636495GRCh37Chr 2, 220283222: 220283222
25NM_002667.3(PLN): c.40_42delAGA (p.Arg14del)deletionPathogenicrs397516784GRCh37Chr 6, 118880124: 118880126
26LDB3NM_001080116.1(LDB3): c.494C> T (p.Ala165Val)single nucleotide variantPathogenicrs121908334GRCh37Chr 10, 88446975: 88446975
27LMNANM_005572.3(LMNA): c.348dupG (p.Lys117Glufs)duplicationPathogenicrs267607646GRCh37Chr 1, 156085057: 156085058
28LMNANM_005572.3(LMNA): c.607G> A (p.Glu203Lys)single nucleotide variantPathogenicrs61195471GRCh37Chr 1, 156104287: 156104287
29LMNANM_005572.3(LMNA): c.673C> T (p.Arg225Ter)single nucleotide variantPathogenicrs60682848GRCh37Chr 1, 156104629: 156104629
30LMNANM_005572.3(LMNA): c.799T> C (p.Tyr267His)single nucleotide variantPathogenicrs267607593GRCh37Chr 1, 156104755: 156104755
31LMNANM_005572.3(LMNA): c.958delC (p.Leu320Phefs)deletionPathogenicrs397517915GRCh37Chr 1, 156105713: 156105713
32LMNANM_005572.3(LMNA): c.961C> T (p.Arg321Ter)single nucleotide variantPathogenicrs267607554GRCh37Chr 1, 156105716: 156105716
33TCAPNM_003673.3(TCAP): c.157C> T (p.Gln53Ter)single nucleotide variantLikely pathogenic, Pathogenicrs104894655GRCh37Chr 17, 37822015: 37822015
34SLC26A2NM_000112.3(SLC26A2): c.-26+2T> Csingle nucleotide variantPathogenicrs386833492GRCh37Chr 5, 149340544: 149340544
35SLC26A2NM_000112.3(SLC26A2): c.1020_1022delTGT (p.Val341del)deletionPathogenicrs121908077GRCh37Chr 5, 149360176: 149360178
36SCN5ANM_000335.4(SCN5A): c.4780G> C (p.Asp1594His)single nucleotide variantPathogenicrs137854607GRCh37Chr 3, 38595800: 38595800

Expression for genes affiliated with Dilated Cardiomyopathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dilated Cardiomyopathy

Search GEO for disease gene expression data for Dilated Cardiomyopathy.

Pathways for genes affiliated with Dilated Cardiomyopathy

About this section
Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG, 5Cell Signaling Technology, 51PharmGKB
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Pathways related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0LMNA, TMPO
2
Show member pathways
9.8ACTC1, VCL, TNNT2
3
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.8ACTC1, MYH7, VCL
49.8TNNT2, MYH7, ACTC1
59.4ACTC1, VCL, LMNA, TMPO, TNNT2
69.2PLN, LMNA, SCN5A
79.2TNNT2, SCN5A, ACTC1
8
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.0PLN, ACTC1, MYH7, LMNA, SGCD, TNNT2
98.7TNNT2, SCN5A, MYH7, ACTC1, PLN

Compounds for genes affiliated with Dilated Cardiomyopathy

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45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank
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Compounds related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1actomyosin4510.0ACTC1, MYH7
2creatinine459.3ACTC1, MYH7, LMNA, TNNT2
3calcium45 51 24 1111.0PLN, TNNT2, SCN5A, TMPO, LMNA, VCL

GO Terms for genes affiliated with Dilated Cardiomyopathy

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16Gene Ontology
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Cellular components related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:0300179.8ACTC1, MYH7, TNNT2
2Z discGO:0300189.4CSRP3, LDB3, NEXN, MYH7
3cytoskeletonGO:0058568.9SGCD, VCL, NEXN, LDB3, CSRP3

Biological processes related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ATPase activityGO:03278010.3TNNT2, PLN
2cardiac myofibril assemblyGO:05500310.1CSRP3, ACTC1
3cardiac muscle tissue developmentGO:04873810.1TAZ, CSRP3, PLN
4sarcomere organizationGO:04521410.1TNNT2, LDB3
5regulation of heart contractionGO:00801610.1PLN, TNNT2
6regulation of the force of heart contractionGO:00202610.0MYH7, PLN, CSRP3
7muscle contractionGO:00693610.0VCL, MYH7, TAZ
8muscle filament slidingGO:03004910.0ACTC1, MYH7, TNNT2
9ATP catabolic processGO:0062009.8ACTC1, MYH7, TNNT2
10muscle organ developmentGO:0075179.8FKTN, LMNA, SGCD
11ventricular cardiac muscle tissue morphogenesisGO:0550109.7MYH7, TNNT2
12regulation of cardiac muscle cell contractionGO:0860049.6PLN, SCN5A
13regulation of heart rateGO:0020279.3MYH7, SCN5A
14cardiac muscle contractionGO:0600489.3TAZ, CSRP3, ACTC1, SCN5A

Molecular functions related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATPase activityGO:0168879.8ACTC1, MYH7, TNNT2

Products for genes affiliated with Dilated Cardiomyopathy

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Sources for Dilated Cardiomyopathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet