DCM
MCID: DLT002
MIFTS: 87

Dilated Cardiomyopathy (DCM) malady

Genetic diseases, Rare diseases, Cardiovascular diseases, Muscle diseases, Ear diseases, Neuronal diseases categories

Summaries for Dilated Cardiomyopathy

About this section


NIH Rare Diseases:42 Dilated cardiomyopathy is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. it is the most common type of cardiomyopathy and typically affects those aged 20 to 60. the left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. the heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. over time, the heart becomes weaker and heart failure can occur. while the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired or inherited. last updated: 9/29/2011

MalaCards based summary: Dilated Cardiomyopathy, also known as primary dilated cardiomyopathy, is related to congestive heart failure and muscular dystrophy. An important gene associated with Dilated Cardiomyopathy is LMNA (lamin A/C), and among its related pathways are Nuclear Envelope Reassembly and Antiarrhythmic Pathway, Pharmacodynamics. The drugs inamrinone and inamrinone lactate and the compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and lung, and related mouse phenotypes are behavior/neurological and muscle.

Disease Ontology:9 An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart.

Wikipedia:64 Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot... more...

Descriptions from OMIM:46 115200, 613881, 613286, 611880, 300069 601493, 611879, 613697, 608569, 607482, 607487, 612158, 613426, 601494, 613642, 611615, 609909, 613252, 613424, 612877, 601154, 613172, 613122, 614672, 604765, 613694, 606685, 604145, 611407, 611878, 302045, 605362, 613740 more

GeneReviews summary for dcm-ov

Aliases & Classifications for Dilated Cardiomyopathy

About this section

Dilated Cardiomyopathy, Aliases & Descriptions:

Name: Dilated Cardiomyopathy 31 9 20 42 21 11 44
Primary Dilated Cardiomyopathy 9 23 61
Dcm 42 38
Cardiomyopathy, Familial Idiopathic 61
 
Idiopathic Dilated Cardiomyopathy 42
Cardiomyopathy, Congestive 9
Cardiomyopathy, Dilated 61


Classifications:



Related Diseases for Dilated Cardiomyopathy

About this section

Diseases in the Dilated Cardiomyopathy family:

Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines
Familial Dilated Cardiomyopathy Taz-Related Dilated Cardiomyopathy
Tnnt2-Related Dilated Cardiomyopathy Myh7-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Tpm1-Related Dilated Cardiomyopathy
Des-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Ldb3-Related Dilated Cardiomyopathy Pln-Related Dilated Cardiomyopathy
Scn5a-Related Dilated Cardiomyopathy Dmd-Related Dilated Cardiomyopathy
Ttn-Related Dilated Cardiomyopathy Csrp3-Related Dilated Cardiomyopathy
Tcap-Related Dilated Cardiomyopathy Abcc9-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy Actn2-Related Dilated Cardiomyopathy
Tnnc1-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Psen2-Related Dilated Cardiomyopathy Psen1-Related Dilated Cardiomyopathy
Eya4-Related Dilated Cardiomyopathy Tmpo-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Dsg2-Related Dilated Cardiomyopathy
Nexn-Related Dilated Cardiomyopathy Rbm20-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1ll Cardiomyopathy, Dilated, 1cc
Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1aa
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 1z Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1gg Cardiomyopathy, Dilated, 1l
Cardiomyopathy, Dilated, 1k Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1p Cardiomyopathy, Dilated, 1j
Cardiomyopathy, Dilated, 2b Cardiomyopathy, Dilated, 1q
Cardiomyopathy, Dilated 1b Cardiomyopathy, Dilated, 1x
Cardiomyopathy, Dilated, 1kk Cardiomyopathy, Dilated, 1w
Cardiomyopathy, Dilated 1c Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1mm Cardiomyopathy, Dilated, 1ii
Cardiomyopathy, Dilated, 1o Cardiomyopathy, Dilated, 1t
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1u
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1n
Cardiomyopathy, Dilated, 1bb Cardiomyopathy, Dilated, 2a
Cardiomyopathy, Dilated, 1ff Severe Dilated Cardiomyopathy Due to Lamin a/c Mutation

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 283)
idRelated DiseaseScoreTop Affiliating Genes
1congestive heart failure31.9TNNT2
2muscular dystrophy31.8DES, SGCD, LMNA, FKTN, TCAP
3hypertrophic cardiomyopathy31.7CSRP3, ACTC1, MYH7, TPM1, TNNT2
4endocardial fibroelastosis31.7TAZ
5myopathy31.6MYH7, FKTN, TCAP, LDB3, TAZ, LMNA
6becker muscular dystrophy31.5VCL, FKTN
7atrioventricular block31.4LMNA, SCN5A
8emery-dreifuss muscular dystrophy31.4LMNA, TMPO
9nemaline myopathy31.3DES, TPM1
10duchenne muscular dystrophy31.2DES, TNNT2, SGCD, VCL, FKTN, TCAP
11barth syndrome31.1LDB3, TAZ
12neuropathy31.1SGCD, LMNA, FKTN
13long qt syndrome30.9MYH7, SCN5A
14limb-girdle muscular dystrophy30.9TCAP
15ischemia30.8TNNT2, SCN5A, VCL, MYH7
16familial hypertrophic cardiomyopathy30.8TNNT2, TPM1, MYH7, TCAP, ACTC1, PLN
17familial dilated cardiomyopathy11.1
18myocarditis10.9
19fasciitis10.6ACTC1
20dmd-associated dilated cardiomyopathy10.6
21infantile myofibromatosis10.6DES
22epithelioid leiomyosarcoma10.6ACTC1, DES
23familial restrictive cardiomyopathy10.6DES, MYH7
24pseudosarcomatous fibromatosis10.6DES, ACTC1
25spindle cell carcinoma10.6DES, ACTC1
26spindle cell sarcoma10.6ACTC1, DES
27desmoid tumor10.6DES, ACTC1
28cutaneous fibrous histiocytoma10.6DES, ACTC1
29congenital heart disease10.6TNNT2, SCN5A, LMNA, MYH7
30distal muscular dystrophy10.6DES, MYH7
31leiomyosarcoma10.6DES, VCL, ACTC1
32adenosarcoma10.6DES, ACTC1
33congenital heart block10.6SCN5A, LMNA
34dermatofibrosarcoma protuberans10.6DES, ACTC1
35calpainopathy10.6TCAP, LMNA
36fibrous histiocytoma10.6DES, ACTC1
37endometrial stromal sarcoma10.6DES, ACTC1
38familial atrial fibrillation10.6SCN5A
39sudden cardiac death multi-gene panels10.6TNNT2, SCN5A, TPM1, LMNA, MYH7
40rhabdoid tumor10.6ACTC1, DES
41acute myocarditis10.5
42dilated cardiomyopathy with ataxia syndrome10.5
43myofibrillar myopathy10.5DES, LDB3, BAG3
44neuromuscular disease10.5DES, TMPO, LMNA, VCL, TCAP
45hemangiopericytoma10.5DES, ACTC1
46angiomyolipoma10.5DES, ACTC1
47rhabdomyosarcoma10.5ACTC1, VCL, DES
48paraganglioma10.5DES, ACTC1
49fibroma10.5DES, ACTC1
50embryonal rhabdomyosarcoma10.5DES, ACTC1

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to dilated cardiomyopathy

Symptoms for Dilated Cardiomyopathy

About this section

Drugs & Therapeutics for Dilated Cardiomyopathy

About this section

Drug clinical trials:

Search ClinicalTrials for Dilated Cardiomyopathy

Search NIH Clinical Center for Dilated Cardiomyopathy

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.

Genetic Tests for Dilated Cardiomyopathy

About this section

Genetic tests related to Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Dilated Cardiomyopathy21 VCL
2 Primary Dilated Cardiomyopathy23

Anatomical Context for Dilated Cardiomyopathy

About this section

MalaCards organs/tissues related to Dilated Cardiomyopathy:

32
Heart, Bone, Lung, Liver, Monocytes, Testes, Brain, Bone marrow, T cells, Skeletal muscle, Endothelial, Kidney, Eye, Whole blood, Spleen, Thyroid, B cells, Cardiac myocytes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
id TissueAnatomical CompartmentCell Relevance
1 HeartMyocardiumCardiomyocytes Affected by disease
2 HeartLeft VentricleCardiomyocytes Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Dilated Cardiomyopathy or affiliated genes

About this section

MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.2SCN5A, LMNA, FKTN, TCAP, LDB3, PLN
2MP:000536910.0BAG3, DES, TNNT2, SCN5A, SGCD, LMNA
3MP:000538510.0TPM1, SGCD, SCN5A, TNNT2, DES, LMNA
4MP:000537810.0TNNT2, SCN5A, TPM1, EYA4, LMNA, VCL
5MP:00107689.9EYA4, TPM1, SGCD, SCN5A, TNNT2, DES
6MP:00053769.9LMNA, SGCD, TNNT2, DES, FKTN, TCAP
7MP:00053849.8SCN5A, TMPO, LMNA, VCL, FKTN, TCAP

Publications for Dilated Cardiomyopathy

About this section

Articles related to Dilated Cardiomyopathy:

(show top 50)    (show all 1338)
idTitleAuthorsYear
1
Effects of PPARI+/PGC-1I+ on the myocardial energy metabolism during heart failure in the doxorubicin induced dilated cardiomyopathy in mice. (25356095)
2014
2
Heart Mitochondrial Proteome Study Elucidates Changes in Cardiac Energy Metabolism and Antioxidant PRDX3 in Human Dilated Cardiomyopathy. (25397948)
2014
3
Eosinophilic myocarditis due to Churg-Strauss syndrome mimicking reversible dilated cardiomyopathy. (24157381)
2014
4
Sphericity Index and E-Point-to-Septal-Separation (EPSS) to Diagnose Dilated Cardiomyopathy in Doberman Pinschers. (24428318)
2014
5
Cerebral infarction in both carotid and vertebrobasilar territories associated with a persistent primitive hypoglossal artery with severe dilated cardiomyopathy. (22959108)
2014
6
Anticoagulation in patients with dilated cardiomyopathy, low ejection fraction, and sinus rhythm: back to the drawing board. (23279759)
2013
7
Prediction of improvement in cardiac function by high dose dobutamine stress echocardiography in patients with recent onset idiopathic dilated cardiomyopathy. (23312406)
2013
8
Response to letters regarding article, "Myocardial fibrosis as a key determinant of left ventricular remodeling in idiopathic dilated cardiomyopathy: a contrast-enhanced cardiovascular magnetic study". (24254489)
2013
9
Follow-up of the patients after stem cell transplantation for pediatric dilated cardiomyopathy. (23458132)
2013
10
Fibrosis and mortality in patients with dilated cardiomyopathy. (23800925)
2013
11
A1180V of cardiac sodium channel gene (SCN5A): is it a risk factor for dilated cardiomyopathy or just a common variant in Han Chinese? (24227891)
2013
12
Prognostic value of left atrial volume in patients with dilated cardiomyopathy. (24119867)
2013
13
Prognostic value of late gadolinium enhancement in dilated cardiomyopathy patients. A meta-analysis. (23860892)
2013
14
Autoimmunity against Ma88muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype. (22328321)
2012
15
Human leukocyte antigen-DQ beta 1 chain (DQB1) gene polymorphisms are associated with dilated cardiomyopathy: a systematic review and meta-analysis. (22386792)
2012
16
Mitral valve surgery for severe mitral regurgitation and dilated cardiomyopathy--a bridge to transplant: case report and a review of literature. (22309207)
2012
17
Clinical and functional capacity of patients with dilated cardiomyopathy after four years of transplantation. (23515729)
2012
18
SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism. (21596231)
2011
19
Familial dilated cardiomyopathy. (21574539)
2011
20
A novel custom resequencing array for dilated cardiomyopathy. (20474083)
2010
21
Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy. (19480714)
2009
22
Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure. (19944367)
2009
23
Polymorphisms of the beta-1 and beta-2 adrenergic receptors in Polish patients with idiopathic dilated cardiomyopathy. (19378229)
2009
24
Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy. (18940188)
2009
25
Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes. (19324307)
2009
26
ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy. (18165925)
2008
27
Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. (17987279)
2008
28
Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report]. (19169978)
2008
29
Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy. (17292982)
2008
30
Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. (17620508)
2007
31
Dilated cardiomyopathy and adipic aciduria in nutritional rickets. (16628102)
2006
32
Does the C-type natriuretic peptide have prognostic value in chagas disease and other dilated cardiomyopathies? (17204908)
2006
33
Content of myosin-activating protein kinases in myocardium of patients with dilated cardiomyopathy and in the animal heart]. (17131835)
2006
34
Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. (16387818)
2006
35
The influence of aetiology on inflammatory and neurohumoral activation in patients with severe heart failure: a prospective study comparing Chagas' heart disease and idiopathic dilated cardiomyopathy. (16043406)
2005
36
HLA-DQA1, -DQB1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy in Hans of northern China. (15996167)
2005
37
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. (15034580)
2004
38
Metavinculin mutations alter actin interaction in dilated cardiomyopathy. (11815424)
2002
39
Usefulness of cardiac transplantation in children with visceral heterotaxy (asplenic and polysplenic syndromes and single right-sided spleen with levocardia) and comparison of results with cardiac transplantation in children with dilated cardiomyopathy. (12031727)
2002
40
Mutations in the dystrophin gene are associated with sporadic dilated cardiomyopathy. (12359139)
2002
41
Case of AlstrAPm syndrome with late presentation dilated cardiomyopathy. (11767878)
2001
42
A case of chorea-acanthocytosis with dilated cardiomyopathy and myopathy]. (11218703)
2000
43
Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy. (11140941)
2000
44
Mitochondrial respiratory chain activity in idiopathic dilated cardiomyopathy. (10746819)
2000
45
Advances in molecular genetics of dilated cardiomyopathy. The Heart Muscle Disease Study Group. (9891591)
1998
46
Reduction of myocardial myoglobin in bovine dilated cardiomyopathy. (9140831)
1997
47
Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A. (9386183)
1997
48
Evidence that polymorphism of the angiotensin I converting enzyme gene may be related to idiopathic dilated cardiomyopathy in the Chinese population. (7492954)
1995
49
Dilated cardiomyopathy and the dystrophin gene: an illustrated review. (7833192)
1994
50
Ventricular adenine nucleotide translocator mRNA is upregulated in dilated cardiomyopathy. (8252591)
1993

Variations for Dilated Cardiomyopathy

About this section

Clinvar genetic disease variations for Dilated Cardiomyopathy:

7 (show all 26)
id Gene Name Type Significance SNP ID Assembly Location
1TNNT2NM_000364.3(TNNT2): c.421C> T (p.Arg141Trp)single nucleotide variantLikely pathogenic, Pathogenicrs74315380GRCh37Chr 1, 201333494: 201333494
2LMNANM_005572.3(LMNA): c.16C> T (p.Gln6Ter)single nucleotide variantPathogenicrs61046466GRCh37Chr 1, 156084725: 156084725
3LMNANM_005572.3(LMNA): c.1445G> A (p.Arg482Gln)single nucleotide variantPathogenicrs11575937GRCh37Chr 1, 156106776: 156106776
4LMNANM_005572.3(LMNA): c.481G> A (p.Glu161Lys)single nucleotide variantPathogenicrs28933093GRCh37Chr 1, 156100532: 156100532
5RBM20NM_001134363.2(RBM20): c.1913C> T (p.Pro638Leu)single nucleotide variantPathogenicrs267607003GRCh37Chr 10, 112572068: 112572068
6RBM20NM_001134363.2(RBM20): c.1906C> A (p.Arg636Ser)single nucleotide variantLikely pathogenic, Pathogenicrs267607002GRCh37Chr 10, 112572061: 112572061
7RBM20NM_001134363.2(RBM20): c.1907G> A (p.Arg636His)single nucleotide variantLikely pathogenic, Pathogenicrs267607004GRCh37Chr 10, 112572062: 112572062
8BAG3NM_004281.3(BAG3): c.367C> T (p.Arg123Ter)single nucleotide variantLikely pathogenic, Pathogenicrs387906875GRCh37Chr 10, 121429549: 121429549
9TPM1NM_001018005.1(TPM1): c.688G> A (p.Asp230Asn)single nucleotide variantPathogenicrs199476317GRCh37Chr 15, 63354462: 63354462
10SCN5ANM_000335.4(SCN5A): c.665G> A (p.Arg222Gln)single nucleotide variantLikely pathogenic, Pathogenicrs45546039GRCh37Chr 3, 38655272: 38655272
11TAZNM_000116.3(TAZ): c.718G> C (p.Gly240Arg)single nucleotide variantPathogenicrs387907218GRCh37Chr X, 153649015: 153649015
12MYH7NM_000257.3(MYH7): c.4522_4524delGAG (p.Glu1508del)deletionLikely pathogenic, Pathogenicrs397516220GRCh37Chr 14, 23886197: 23886199
13MYH7NM_000257.3(MYH7): c.5401G> A (p.Glu1801Lys)single nucleotide variantLikely pathogenic, Pathogenicrs397516248GRCh37Chr 14, 23884362: 23884362
14MYH7NM_000257.3(MYH7): c.5740G> A (p.Glu1914Lys)single nucleotide variantLikely pathogenic, Pathogenicrs397516254GRCh37Chr 14, 23883018: 23883018
15TNNT2NM_000364.3(TNNT2): c.650_652delAGA (p.Lys217del)deletionPathogenicrs45578238GRCh37Chr 1, 201331099: 201331101
16DESNM_001927.3(DES): c.38C> T (p.Ser13Phe)single nucleotide variantPathogenicrs62636495GRCh37Chr 2, 220283222: 220283222
17NM_002667.3(PLN): c.40_42delAGA (p.Arg14del)deletionPathogenicrs397516784GRCh37Chr 6, 118880124: 118880126
18LDB3NM_001080116.1(LDB3): c.494C> T (p.Ala165Val)single nucleotide variantPathogenicrs121908334GRCh37Chr 10, 88446975: 88446975
19LMNANM_005572.3(LMNA): c.348dupG (p.Lys117Glufs)duplicationPathogenicrs267607646GRCh37Chr 1, 156085057: 156085058
20LMNANM_005572.3(LMNA): c.607G> A (p.Glu203Lys)single nucleotide variantPathogenicrs61195471GRCh37Chr 1, 156104287: 156104287
21LMNANM_005572.3(LMNA): c.673C> T (p.Arg225Ter)single nucleotide variantPathogenicrs60682848GRCh37Chr 1, 156104629: 156104629
22LMNANM_005572.3(LMNA): c.799T> C (p.Tyr267His)single nucleotide variantPathogenicrs267607593GRCh37Chr 1, 156104755: 156104755
23LMNANM_005572.3(LMNA): c.958delC (p.Leu320Phefs)deletionPathogenicrs397517915GRCh37Chr 1, 156105713: 156105713
24LMNANM_005572.3(LMNA): c.961C> T (p.Arg321Ter)single nucleotide variantPathogenicrs267607554GRCh37Chr 1, 156105716: 156105716
25TCAPNM_003673.3(TCAP): c.157C> T (p.Gln53Ter)single nucleotide variantLikely pathogenic, Pathogenicrs104894655GRCh37Chr 17, 37822015: 37822015
26SCN5ANM_000335.4(SCN5A): c.4780G> C (p.Asp1594His)single nucleotide variantPathogenicrs137854607GRCh37Chr 3, 38595800: 38595800

Expression for genes affiliated with Dilated Cardiomyopathy

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Dilated Cardiomyopathy patients vs. healthy controls: 31 (show all 2)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1SELEselectin EHeart-1.930.017
2CCL2chemokine (C-C motif) ligand 2Heart-1.860.045

Expression patterns in normal tissues for genes affiliated with Dilated Cardiomyopathy

Search GEO for disease gene expression data for Dilated Cardiomyopathy.

Pathways for genes affiliated with Dilated Cardiomyopathy

About this section

Pathways related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.4LMNA, TMPO
210.4LMNA, PLN, SCN5A
310.4TNNT2, SCN5A, ACTC1
4
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility59
Cytoskeleton remodeling Integrin outside in signaling59
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases59
Cell adhesion Tight junctions59
Development MAG dependent inhibition of neurite outgrowth59
10.3ACTC1, MYH7, VCL
510.3TNNT2, ACTC1, MYH7, TPM1
6
Show member pathways
10.2DES, TNNT2, VCL, TCAP, TPM1, ACTC1
710.2SCN5A, MYH7, PLN, ACTC1, TPM1, TNNT2
810.2TMPO, DES, TNNT2, ACTC1, VCL, TPM1
9
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
10.1SGCD, TPM1, LMNA, MYH7, ACTC1, TNNT2

Compounds for genes affiliated with Dilated Cardiomyopathy

About this section

Compounds related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1orcein4410.6ACTC1, DES
2s 1004410.6ACTC1, DES
3alpha-bungarotoxin44 29 6012.5DES, TMPO
4creatinine4410.5DES, TNNT2, LMNA, MYH7, ACTC1
5reticulin4410.4ACTC1, DES
6mucicarmine4410.4DES, ACTC1
7b 7234410.4ACTC1, DES
8arginine4410.4MYH7, LMNA, TMPO, SCN5A, DES
9calcium44 50 25 1213.3PLN, DES, TNNT2, SCN5A, TPM1, TMPO
10glucose4410.2DES, TMPO, LMNA, VCL, ACTC1
11phalloidin4410.1VCL, DES

GO Terms for genes affiliated with Dilated Cardiomyopathy

About this section

Cellular components related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcomereGO:03001710.4TNNT2, TPM1, MYH7, ACTC1
2I bandGO:03167410.4ACTC1, TCAP
3sarcolemmaGO:04238310.3DES, SCN5A, SGCD
4Z discGO:03001810.3BAG3, CSRP3, LDB3, TCAP, NEXN, MYH7
5cytoskeletonGO:00585610.3SGCD, TPM1, VCL, NEXN, LDB3, CSRP3
6fascia adherensGO:00591610.1VCL, DES
7cytosolGO:00582910.0DES, TNNT2, TPM1, LMNA, VCL, TCAP

Biological processes related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1sarcomere organizationGO:04521410.7TNNT2, TPM1, TCAP, LDB3
2detection of muscle stretchGO:03599510.6CSRP3, TCAP
3cardiac muscle tissue developmentGO:04873810.6TAZ, CSRP3, PLN
4ventricular cardiac muscle tissue morphogenesisGO:05501010.6MYH7, TPM1, TNNT2
5cardiac myofibril assemblyGO:05500310.6TCAP, ACTC1, CSRP3
6regulation of heart contractionGO:00801610.6PLN, TPM1, TNNT2, DES
7skeletal muscle thin filament assemblyGO:03024010.6TCAP, ACTC1
8regulation of the force of heart contractionGO:00202610.6MYH7, PLN, CSRP3
9cardiac muscle hypertrophyGO:00330010.6TCAP, CSRP3
10negative regulation of ATPase activityGO:03278010.6PLN, TNNT2
11muscle contractionGO:00693610.6DES, TPM1, VCL, MYH7, TAZ
12cardiac muscle fiber developmentGO:04873910.6TCAP, NEXN
13muscle filament slidingGO:03004910.6ACTC1, DES, TNNT2, TPM1, MYH7, TCAP
14cardiac muscle contractionGO:06004810.6SCN5A, TPM1, TCAP, ACTC1, CSRP3, TAZ
15regulation of cardiac muscle cell contractionGO:08600410.5PLN, SCN5A
16muscle organ developmentGO:00751710.5SGCD, LMNA, FKTN
17cardiac muscle tissue morphogenesisGO:05500810.5ACTC1, TCAP
18regulation of muscle contractionGO:00693710.5TPM1, TNNT2
19regulation of heart rateGO:00202710.4MYH7, SCN5A
20adult heart developmentGO:00751210.4MYH7, TCAP
21positive regulation of ATPase activityGO:03278110.3TPM1, TNNT2
22ATP catabolic processGO:00620010.0ACTC1, MYH7, TNNT2

Molecular functions related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoskeletal protein bindingGO:00809210.4LDB3, TPM1, DES
2structural constituent of muscleGO:00830710.4CSRP3, TCAP, NEXN, TPM1
3ATPase activityGO:01688710.3ACTC1, MYH7, TNNT2
4actin bindingGO:00377910.3TNNT2, TPM1, VCL, MYH7
5structural constituent of cytoskeletonGO:00520010.3TPM1, TNNT2, DES
6protein bindingGO:0055159.7LMNA, TMPO, SCN5A, DES, VCL, MYH7

Products for genes affiliated with Dilated Cardiomyopathy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Dilated Cardiomyopathy

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet