DCM
MCID: DLT002
MIFTS: 82

Dilated Cardiomyopathy (DCM) malady

Cardiovascular diseases, Genetic diseases categories

Summaries for Dilated Cardiomyopathy

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Dilated cardiomyopathy is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. it is the most common type of cardiomyopathy and typically affects those aged 20 to 60. the left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. the heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. over time, the heart becomes weaker and heart failure can occur. while the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired or inherited. last updated: 9/29/2011

MalaCards: Dilated Cardiomyopathy, also known as primary dilated cardiomyopathy, is related to myocarditis and hypertrophic cardiomyopathy. An important gene associated with Dilated Cardiomyopathy is VCL (vinculin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Cytoskeletal Signaling. The drugs inamrinone and inamrinone lactate and the compounds lipid and calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and lung, and related mouse phenotypes are muscle and mortality/aging.

Disease Ontology:8 An intrinsic cardiomyopathy that results in damage to the myocardium causing the heart to pump blood inefficiently and characterized by an enlarged heart.

Wikipedia:63 Dilated cardiomyopathy or DCM is a condition in which the heart becomes weakened and enlarged and cannot... more...

Description from OMIM:46 604145, 613642, 613252, 609909, 613286 613881, 613172, 607487, 613122, 613697, 300069, 611407, 605362, 613426, 606685, 601493, 608569, 611615, 611878, 613740, 601154, 604765, 612877, 613424, 302045, 613694, 611880, 607482, 612158, 614672, 611879, 115200, 601494 more

GeneReviews summary for dcm-ov

Aliases & Classifications for Dilated Cardiomyopathy

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Sources:
60UMLS, 8Disease Ontology, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 22GTR, 38NCBI Bookshelf, 46OMIM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

dilated cardiomyopathy 8 19 42 20 10 44 30
primary dilated cardiomyopathy 8 22
dcm 42 38
cardiomyopathy, familial idiopathic 60
idiopathic dilated cardiomyopathy 42
cardiomyopathy, congestive 8
cardiomyopathy, dilated 60
diastrophic dysplasia 60


Related Diseases for Dilated Cardiomyopathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Dilated Cardiomyopathy family:

Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines
Familial Dilated Cardiomyopathy Taz-Related Dilated Cardiomyopathy
Tnnt2-Related Dilated Cardiomyopathy Myh7-Related Dilated Cardiomyopathy
Mybpc3-Related Dilated Cardiomyopathy Tpm1-Related Dilated Cardiomyopathy
Des-Related Dilated Cardiomyopathy Sgcd-Related Dilated Cardiomyopathy
Tnni3-Related Dilated Cardiomyopathy Actc1-Related Dilated Cardiomyopathy
Ldb3-Related Dilated Cardiomyopathy Pln-Related Dilated Cardiomyopathy
Scn5a-Related Dilated Cardiomyopathy Dmd-Related Dilated Cardiomyopathy
Ttn-Related Dilated Cardiomyopathy Csrp3-Related Dilated Cardiomyopathy
Tcap-Related Dilated Cardiomyopathy Abcc9-Related Dilated Cardiomyopathy
Vcl-Related Dilated Cardiomyopathy Actn2-Related Dilated Cardiomyopathy
Tnnc1-Related Dilated Cardiomyopathy Ankrd1-Related Dilated Cardiomyopathy
Psen2-Related Dilated Cardiomyopathy Psen1-Related Dilated Cardiomyopathy
Eya4-Related Dilated Cardiomyopathy Tmpo-Related Dilated Cardiomyopathy
Fktn-Related Dilated Cardiomyopathy Dsg2-Related Dilated Cardiomyopathy
Nexn-Related Dilated Cardiomyopathy Rbm20-Related Dilated Cardiomyopathy
Bag3-Related Dilated Cardiomyopathy Myh6-Related Dilated Cardiomyopathy
Cardiomyopathy, Dilated, 1ll Cardiomyopathy, Dilated, 1cc
Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1aa
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1i Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 1e Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1jj Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated 1b
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1kk
Cardiomyopathy, Dilated, 1w Cardiomyopathy, Dilated 1c
Cardiomyopathy, Dilated, 1dd Cardiomyopathy, Dilated, 1hh
Cardiomyopathy, Dilated, 1m Cardiomyopathy, Dilated, 1mm
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1o
Cardiomyopathy, Dilated, 1t Cardiomyopathy, Dilated, 1ee
Cardiomyopathy, Dilated, 1s Cardiomyopathy, Dilated, 1u
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1n
Cardiomyopathy, Dilated, 1bb Cardiomyopathy, Dilated, 2a
Cardiomyopathy, Dilated, 1ff

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis31.2DMD, TNNT2
2hypertrophic cardiomyopathy31.1CSRP3, TNNT2, MYH7, ACTC1
3congestive heart failure30.9TNNT2
4muscular dystrophy30.8SGCD, LMNA, FKTN, DMD
5dmd-associated dilated cardiomyopathy30.8TAZ, DMD
6myopathy30.8FKTN, TNNT2, DMD, LDB3, MYH7, TAZ
7endocardial fibroelastosis30.6TAZ
8becker muscular dystrophy30.5DMD
9familial hypertrophic cardiomyopathy30.5CSRP3, ACTC1, TNNT2, MYH7, PLN
10duchenne muscular dystrophy30.4DMD
11nemaline myopathy30.4ACTC1
12emery-dreifuss muscular dystrophy30.3LMNA, DMD, TMPO
13myocardial infarction30.3TNNT2, LDB3, VCL
14barth syndrome30.1LDB3, TAZ, DNAJC19
15neuropathy30.1LMNA, DMD, SGCD, FKTN
16limb-girdle muscular dystrophy29.9LMNA, DMD, FKTN
17sudden cardiac death multi-gene panels29.9LMNA, TNNT2, MYH7
18myotonic dystrophy29.9DMD, MYH7
19diastrophic dysplasia11.1
20familial dilated cardiomyopathy10.6
21acute myocarditis10.5
22atelosteogenesis10.4
23hypertension10.4
24restrictive cardiomyopathy10.4
25wolff-parkinson-white syndrome10.4
26rickets10.4
27peripartum cardiomyopathy10.4
28chagas disease10.3
29cardiomyopathy dilated with woolly hair and keratoderma10.3
30cardiomyopathy, dilated, 1a10.3
31atrioventricular block10.3
32cushing's syndrome10.3
33epidermolysis bullosa10.3
34hepatitis10.3
35lmna-related dilated cardiomyopathy10.3
36coronary artery disease10.3
37conduct disorder10.3
38respiratory failure10.3
39cardiomyopathy, dilated, 1j10.3
40cardiomyopathy, dilated, 1w10.3
41multiple epiphyseal dysplasia10.2
42otosclerosis10.2
43pseudoachondroplasia10.2
44achondrogenesis10.2
45multiple epiphyseal dysplasia, recessive10.2
46diastrophic dysplasia, broad bone-platyspondylic variant10.2
47hepatitis c10.2
48sensorineural hearing loss10.2
49cardiac sarcoidosis10.2
50hypoparathyroidism10.2

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to dilated cardiomyopathy

Clinical Features for Dilated Cardiomyopathy

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Sources:
46OMIM
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Drugs & Therapeutics for Dilated Cardiomyopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dilated Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Dilated Cardiomyopathy

Search NIH Clinical Center for Dilated Cardiomyopathy

Search CenterWatch for Dilated Cardiomyopathy

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.

Genetic Tests for Dilated Cardiomyopathy

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Dilated Cardiomyopathy20 VCL
2 Primary Dilated Cardiomyopathy22

Anatomical Context for Dilated Cardiomyopathy

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Dilated Cardiomyopathy:

32
Heart, Bone, Lung, Liver, Monocytes, Testes, Brain, Skeletal muscle, T cells, Endothelial, Bone marrow, Kidney, B cells, Thyroid, Whole blood, Spleen, Eye, Cardiac myocytes

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
id TissueAnatomical CompartmentCell Relevance
1 HeartMyocardiumCardiomyocytes Affected by disease
2 HeartLeft VentricleCardiomyocytes Potential therapeutic candidate, affected by disease
3 BloodCord BloodMesenchymal Stem Cells Potential therapeutic candidate
4 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Dilated Cardiomyopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536911.9LDB3, PDCD1, CSRP3, TNNT2, DMD, FKTN
2MP:001076811.8DMD, TNNT2, CSRP3, PDCD1, EYA4, FKTN
3MP:000538511.7DMD, TNNT2, CSRP3, PDCD1, PLN, LMNA
4MP:000537811.6CSRP3, TNNT2, DMD, FKTN, LMNA, ACTC1
5MP:000538110.9EYA4, DMD, LMNA, VCL, TMPO, LDB3

Publications for Dilated Cardiomyopathy

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Sources:
50PubMed
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Articles related to Dilated Cardiomyopathy:

(show top 50)    (show all 1356)
idTitleAuthorsYear
1
Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. (23418287)
2013
2
Segmental myocardial velocities in dilated cardiomyopathy with and without left bundle branch block. (22987362)
2013
3
Relationship between the elevated mean platelet volume and coronary microvascular function in patients with idiopathic dilated cardiomyopathy. (22463126)
2013
4
Successful cardiac resynchronization therapy in a 1.5-year-old girl with dilated cardiomyopathy and functional mitral regurgitation. (23651819)
2013
5
Endomyocardial biopsy in new onset dilated cardiomyopathy: prevalence and prognostic role of infectious agents. (23992928)
2013
6
Family history of dilated cardiomyopathy among patients with heart failure from the HF-ACTION genetic ancillary study. (23751021)
2013
7
Pregnancy with dilated and peripartum cardiomyopathy: maternal and fetal outcome. (22955293)
2013
8
Preliminary clinical study of left ventricular myocardial strain in patients with non-ischemic dilated cardiomyopathy by three-dimensional speckle tracking imaging. (22397470)
2012
9
Identification of novel mutations in LMNA associated with familial forms of dilated cardiomyopathy. (22224630)
2012
10
Combined spinal-epidural anesthesia for cesarean section in a patient with dilated cardiomyopathy. (22557770)
2012
11
Idiopathic dilated cardiomyopathy: possible triggers and treatment strategies. (22618228)
2012
12
Prognostic relevance of heart rate at rest for survival and the quality of life in patients with dilated cardiomyopathy. (22454138)
2012
13
Kidney infarction in Friedreich's ataxia with dilated cardiomyopathy. (23035161)
2012
14
Dilated cardiomyopathy associated with celiac disease: case report and literature review. (23289283)
2012
15
Increased expression of integrin-linked kinase improves cardiac function and decreases mortality in dilated cardiomyopathy model of rats. (22348065)
2012
16
Reading between the Lyme: is Borrelia burgdorferi a cause of dilated cardiomyopathy? The debate continues. (22499544)
2012
17
Effects of treatment on respiratory rate, serum natriuretic peptide concentration, and Doppler echocardiographic indices of left ventricular filling pressure in dogs with congestive heart failure secondary to degenerative mitral valve disease and dilated cardiomyopathy. (21838584)
2011
18
Guidelines for the diagnosis and management of familial dilated cardiomyopathy. (21885340)
2011
19
Identification of mutational hot spots in LMNA encoding lamin A/C in patients with familial dilated cardiomyopathy. (18795223)
2009
20
Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy. (19590045)
2009
21
Pathogenesis and therapy of autoimmunity-induced dilated cardiomyopathy. (19273156)
2009
22
Cardiac magnetic resonance in acute myocarditis and dilated cardiomyopathy. (19396051)
2009
23
Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. (17987279)
2008
24
Sudden infant death from dilated cardiomyopathy with endocardial fibroelastosis. (18442941)
2008
25
A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy. (18678517)
2008
26
Potential role of N-cadherin in hepatocyte growth factor (HGF) mediated improvement of the cardiac function of dilated cardiomyopathy mice. (18495274)
2008
27
Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: a preliminary study. (17400681)
2007
28
Increases in circulating T lymphocytes expressing HLA-DR and CD40 ligand in patients with dilated cardiomyopathy. (17879023)
2007
29
Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. (16387818)
2006
30
An isoform shift in the cardiac adenine nucleotide translocase expression alters the kinetic properties of the carrier in dilated cardiomyopathy. (16107323)
2006
31
Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy. (16153393)
2005
32
Comparative study of the roles of cytokines and apoptosis in dilated and hypertrophic cardiomyopathies. (15217753)
2004
33
Sarcolemmal fragility secondary to the degradation of dystrophin in dilated cardiomyopathy, as estimated by electron microscopy. (19641652)
2003
34
Primary systemic carnitine deficiency presenting as recurrent Reye-like syndrome and dilated cardiomyopathy. (12635840)
2002
35
Association between aldosterone synthase (CYP11B2) gene polymorphism and left ventricular volume in patients with dilated cardiomyopathy. (12433910)
2002
36
Cardiac troponin T: its role in the diagnosis of clinically suspected acute myocarditis and chronic dilated cardiomyopathy in children. (12211203)
2002
37
Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy. (11214703)
2001
38
Current perspective new insights into the molecular basis of familial dilated cardiomyopathy. (11374497)
2001
39
Nuclear membrane proteins in failing human dilated cardiomyopathy. (11747209)
2001
40
Mitochondrial respiratory chain activity in idiopathic dilated cardiomyopathy. (10746819)
2000
41
Familial dilated cardiomyopathy. (10534480)
1999
42
A novel Alu-like element rearranged in the dystrophin gene causes a splicing mutation in a family with X-linked dilated cardiomyopathy. (9683584)
1998
43
Use of serum creatine kinase MM isoforms for predicting the progression of left ventricular dilation in patients with hypertrophic cardiomyopathy. (9152783)
1997
44
The natural history and spectrum of idiopathic dilated cardiomyopathy, including HIV and peripartum cardiomyopathy. (7612985)
1995
45
Unchanged protein levels of SERCA II and phospholamban but reduced Ca2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. (7586307)
1995
46
Maintenance of forearm vasodilator action of atrial natriuretic factor in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. (1533988)
1992
47
Failure of atrial natriuretic factor to increase with saline load in patients with dilated cardiomyopathy and mild heart failure. (1834698)
1991
48
Sympathetic activation in dogs with congestive heart failure caused by chronic mitral valve disease and dilated cardiomyopathy. (2272879)
1990
49
A familial dilated cardiomyopathy associated with cataracts and hip-spine disease. (3965265)
1985
50
Diagnosis of endocardial fibroelastosis by endomyocardial biopsy in an adult with dilated cardiomyopathy. (3984849)
1985

Genetic Variations for Dilated Cardiomyopathy

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Expression for genes affiliated with Dilated Cardiomyopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dilated Cardiomyopathy

Search GEO for disease gene expression data for Dilated Cardiomyopathy.

Pathways for genes affiliated with Dilated Cardiomyopathy

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Sources:
29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
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Compounds for genes affiliated with Dilated Cardiomyopathy

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipid4411.2MYH7, TAZ, PLN, LMNA, VCL, DMD
2calcium44 49 11 2414.1TNNT2, DMD, MYH7, PLN, LMNA, ACTC1
3creatinine4411.1ACTC1, LMNA, MYH7, DMD, TNNT2
4alpha-bungarotoxin44 5911.6DMD, TMPO

GO Terms for genes affiliated with Dilated Cardiomyopathy

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16Gene Ontology
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Cellular components related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Z discGO:03001811.3VCL, CSRP3, DMD, NEXN, MYH7, LDB3
2cytoskeletonGO:00585611.2LDB3, VCL, SGCD, CSRP3, NEXN
3sarcomereGO:03001710.8ACTC1, TNNT2, MYH7
4cell-substrate junctionGO:03005510.8DMD, VCL
5sarcolemmaGO:04238310.7VCL, SGCD, DMD
6costamereGO:04303410.7VCL, DMD
7dystrophin-associated glycoprotein complexGO:01601010.4SGCD, DMD

Biological processes related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004911.2ACTC1, MYH7, DMD, TNNT2
2cardiac muscle contractionGO:06004811.2ACTC1, TAZ, DMD, CSRP3
3muscle organ developmentGO:00751711.2SGCD, LMNA, FKTN, DMD
4cardiac muscle tissue developmentGO:04873811.1CSRP3, TAZ, PLN
5ATP catabolic processGO:00620011.0TNNT2, MYH7, ACTC1
6muscle contractionGO:00693611.0VCL, TAZ, MYH7
7negative regulation of ATPase activityGO:03278010.9PLN, TNNT2
8cardiac myofibril assemblyGO:05500310.9ACTC1, CSRP3
9regulation of ryanodine-sensitive calcium-release channel activityGO:06031410.8PLN, DMD
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:01088110.7DMD, PLN
11regulation of heart rateGO:00202710.7MYH7, DMD
12regulation of the force of heart contractionGO:00202610.6PLN, CSRP3
13sarcomere organizationGO:04521410.4LDB3, TNNT2

Molecular functions related to Dilated Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:00830711.0MYH7, NEXN, DMD, CSRP3
2actin bindingGO:00377910.9TNNT2, DMD, MYH7, VCL
3dystroglycan bindingGO:00216210.7VCL, DMD
4myosin bindingGO:01702210.7ACTC1, DMD
5ATPase activityGO:01688710.5ACTC1, MYH7, TNNT2

Products for genes affiliated with Dilated Cardiomyopathy

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Sources for Dilated Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet