MCID: DPH001
MIFTS: 54

Diphtheria malady

Infectious category

Summaries for Diphtheria

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Diphtheria is a serious bacterial infection. you can catch it from a person who has the infection and coughs or sneezes. you can also get infected by coming in contact with an object, such as a toy, that has bacteria on it. diphtheria usually affects the nose and throat. symptoms include sore throat swollen glands in the neck fever weakness your doctor will diagnose it based on your signs and symptoms and a lab test. getting treatment for diphtheria quickly is important. if your doctor suspects that you have it, you'll start treatment before the lab tests come back. treatment is with antibiotics. the diphtheria, pertussis, and tetanus (dpt) vaccine can prevent diphtheria, but its protection does not last forever. children need another dose, or booster, at about age 12. then, as adults, they should get a booster every 10 years. diphtheria is very rare in the united states because of the vaccine. centers for disease control and prevention

MalaCards: Diphtheria, also known as diphtheria, susceptibility to, is related to tetanus and cutaneous diphtheria. An important gene associated with Diphtheria is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are NAD metabolism and Resolution of Abasic Sites (AP sites). The drugs diphtheria antitoxin and equine diphtheria antitoxin and the compounds jw 55 and nu 1025 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain.

Disease Ontology:8 A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. a milder form of diphtheria can be restricted to the skin. it is caused by corynebacterium diphtheriae, an aerobic gram-positive bacterium. diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

CDC:3 The page you requested has moved.

Wikipedia:64 Diphtheria (Greek διφθέρα (diphthera) \"pair of leather scrolls\") is an upper respiratory tract... more...

Aliases & Classifications for Diphtheria

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

diphtheria 8 43 47 10 45 49 34 61
diphtheria, susceptibility to 9
corynebacterium infections 61
corynebacterium infection 8


External Ids:

Disease Ontology8 DOID:11405
MeSH35 D003354
MESH via Orphanet36 D004165
ICD10 via Orphanet26 A36
SNOMED-CT57 397434007
SNOMED-CT via Orphanet58 397428000
UMLS via Orphanet62 C0012546
ICD1025 A36, A36.9

Related Diseases for Diphtheria

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Diphtheria:



Diseases related to diphtheria

Clinical Features for Diphtheria

Drugs & Therapeutics for Diphtheria

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diphtheria

Drug clinical trials:

Search ClinicalTrials for Diphtheria

Search NIH Clinical Center for Diphtheria

Search CenterWatch for Diphtheria

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Diphtheria

Anatomical Context for Diphtheria

Sources:
33MalaCards
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MalaCards organs/tissues related to Diphtheria:

33
Bone marrow, Whole blood, Brain, Heart, Smooth muscle, Colon, Kidney, Liver, Lung, Breast, Skin, Prostate, Tonsil, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Diphtheria or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Diphtheria

Sources:
51PubMed
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Articles related to Diphtheria:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
Re: Diphtheria Toxin-Epidermal Growth Factor Fusion Protein DAB389EGF for the Treatment of Bladder Cancer. (24411908)
2014
2
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
3
Insights into diphthamide, key diphtheria toxin effector. (23645155)
2013
4
Psoriasis triggered by tetanus-diphtheria vaccination. (23050604)
2013
5
Calibration and commutability assessment of the 1st International Standard for Diphtheria Antitoxin Human. (24011675)
2013
6
Ablation of Breast Cancer Cells Using Trastuzumab-Functionalized Multi-Walled Carbon Nanotubes and Trastuzumab-Diphtheria Toxin Conjugate. (24118702)
2013
7
Comparison of membrane insertion pathways of the apoptotic regulator Bcl-xL and the diphtheria toxin translocation domain. (24134052)
2013
8
Use of Imaged Capillary Isoelectric Focusing (icIEF) Technique in Development of Diphtheria Toxin mutant CRM197. (24375281)
2013
9
ACOG Committee Opinion No. 566: Update on immunization and pregnancy: tetanus, diphtheria, and pertussis vaccination. (23812487)
2013
10
Importance of timing of maternal combined tetanus, diphtheria, and acellular pertussis (Tdap) immunization and protection of young infants. (23097585)
2013
11
Association of postpartum maternal tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine administration and timeliness of infant immunization. (23694833)
2013
12
How French physicians manage with a future change in the primary vaccination of infants against diphtheria, tetanus, pertussis and poliomyelitis? A qualitative study with focus groups. (23782853)
2013
13
Folding of diphtheria toxin T-domain in the presence of amphipols and fluorinated surfactants: Toward thermodynamic measurements of membrane protein folding. (21945883)
2012
14
Persistence of humoral immunity to tetanus and diphtheria in hematopoietic stem cell transplant recipients after post-transplant immunization. (22514148)
2012
15
Reduced-antigen, combined diphtheria, tetanus and acellular pertussis vaccine, adsorbed (BoostrixAr): a review of its properties and use as a single-dose booster immunization. (22931522)
2012
16
Safety and immunogenicity of a quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine in infants and toddlers: three multicenter phase III studies. (22814965)
2012
17
Accessibility changes within diphtheria toxin T domain upon membrane penetration probed by hydrogen exchange and mass spectrometry. (21986198)
2011
18
Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P3 and IGF2-P4 regulatory sequences. (21686134)
2011
19
Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum women. (21946190)
2011
20
Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted vaccine coadministered with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine and/or meningococcal conjugate vaccine to healthy girls 11 to 18 years of age: results from a randomized open trial. (21817954)
2011
21
Transcutaneous vaccination using a hydrogel patch induces effective immune responses to tetanus and diphtheria toxoid in hairless rat. (20493218)
2011
22
Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. (22098755)
2011
23
Decennial administration of a reduced antigen content diphtheria and tetanus toxoids and acellular pertussis vaccine in young adults. (20704493)
2010
24
Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations. (20559701)
2010
25
Sensitivity of cancer cells to truncated diphtheria toxin. (20463924)
2010
26
Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB). (19588375)
2009
27
Primary immunization with a triple diphtheria-tetanus-whole cell pertussis vaccine in Iranian infants: an analysis of antibody response. (19671937)
2009
28
Humoral immune response after post-chemotherapy booster diphtheria-tetanus-pertussis vaccine in pediatric oncology patients. (18937325)
2009
29
Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study. (19804643)
2009
30
The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms. (19780588)
2009
31
ACOG Committee Opinion No. 438: Update on immunization and pregnancy: tetanus, diphtheria, and pertussis vaccination. (19623004)
2009
32
In-migration and diphtheria mortality among children in the Sundsvall region during the epidemics of the 1880s. (17768143)
2008
33
Seroimmunity to diphtheria and tetanus among mother-infant pairs; the role of maternal immunity on infant immune response to diphtheria-tetanus vaccination. (18481231)
2008
34
Reducing anti-DT IgG concentrations to improve the efficacy of a diphtheria fusion protein. (18827566)
2008
35
Immunogenicity and safety of combined diphtheria tetanus whole cell pertussis hepatitis B/ Haemophilus influenzae type b vaccine in Indian infants. (17684303)
2007
36
Transgenic tomatoes express an antigenic polypeptide containing epitopes of the diphtheria, pertussis and tetanus exotoxins, encoded by a synthetic gene. (17619922)
2007
37
Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin. (16901746)
2006
38
Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity. (15003313)
2004
39
Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin. (14756556)
2004
40
Corynebacterium diphtheriae surface proteins as adhesins to human erythrocytes. (11313140)
2001
41
Characterization of the deoxyribonuclease and ADP-ribosyltransferase activities of CRM45, a truncated homologue of diphtheria toxin. (9783263)
1998
42
Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites. (7790364)
1995
43
Inhibition of HIV production in cells containing an integrated, HIV-regulated diphtheria toxin A chain gene. (1736939)
1992
44
Characterization of the deoxyribonuclease activity of diphtheria toxin. (2318891)
1990
45
An unusual case of cutaneous diphtheria. (79663)
1978
46
Diphtheria as a model. Introduction of serums and vaccines for scarlet fever and pneumococcal pneumonia. (4147662)
1973
47
Polyneuritis following cutaneous diphtheria. (14880919)
1951
48
Scarlet fever, diphtheria, measles, and whooping cough in Glasgow from 1916 to 1945. (18120885)
1949
49
A CASE OF CUTANEOUS DIPHTHERIA AS THE CAUSE OF AN OUTBREAK. (20774726)
1929
50
CURRENT IMMUNIZATION PRACTICE IN DIPHTHERIA, SCARLET FEVER AND MEASLES. (18011999)
1926

Genetic Variations for Diphtheria

Expression for genes affiliated with Diphtheria

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diphtheria

Search GEO for disease gene expression data for Diphtheria.

Pathways for genes affiliated with Diphtheria

Sources:
12EMD Millipore, 54Reactome, 30KEGG, 56SinoBiological, 52QIAGEN
See all sources

Pathways related to Diphtheria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NAD metabolism
Hide members
10.5PARP4, PARP2, PARP3, PARP1, TNKS2, TNKS
2
Hide members
10.5PARP1, PARP3, PARP2, PARP4
3
Hide members
10.5PARP3, PARP11, PARP1
410.5TNKS2, TNKS

Compounds for genes affiliated with Diphtheria

Sources:
60Tocris Bioscience, 29IUPHAR, 24HMDB, 45Novoseek, 11DrugBank
See all sources

Compounds related to Diphtheria according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1jw 556010.8PARP6, PARP1, TNKS2, TNKS, PARP12, PARP11
2nu 10256010.8PARP6, PARP4, PARP14, PARP10, PARP15, PARP2
3wiki46010.8PARP2, PARP8, PARP16, PARP3, PARP9, PARP11
4pj 34 hydrochloride6010.8TNKS, TNKS2, PARP15, PARP2, PARP8, PARP16
5nad29 2411.8PARP6, PARP1, TNKS2, TNKS, TIPARP, PARP12
6xav 9396010.7PARP6, PARP4, PARP14, PARP10, PARP15, PARP2
7adpribose4510.6TNKS, PARP1, PARP3, PARP2, PARP4
8nadh45 11 2412.6PARP4, PARP2, PARP3, PARP1, TNKS2, TNKS
9(2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium1110.5PARP1, PARP2
103-aminobenzamide4510.5PARP1, TNKS
11N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE1110.4PARP15, PARP3
12quinazolinone4510.2PARP2, PARP1

GO Terms for genes affiliated with Diphtheria

Sources:
16Gene Ontology
See all sources

Cellular components related to Diphtheria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.6DPH3, ZC3HAV1, PARP1, PARP12, PARP9, PARP3
2pericentriolar materialGO:00024210.4TNKS2, TNKS
3nuclear chromosome, telomeric regionGO:00078410.2TNKS2, TNKS

Biological processes related to Diphtheria according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein ADP-ribosylationGO:00647110.7PARP4, TIPARP, TNKS, TNKS2, PARP1, PARP3
2protein poly-ADP-ribosylationGO:07021210.6PARP10, PARP1, TNKS
3protein auto-ADP-ribosylationGO:07021310.6TNKS, TNKS2
4DNA repairGO:00628110.5PARP4, PARP2, PARP3, PARP1
5positive regulation of telomere maintenance via telomeraseGO:03221210.5TNKS2, TNKS
6protein localization to chromosome, telomeric regionGO:07019810.4TNKS2, TNKS
7peptidyl-diphthamide biosynthetic process from peptidyl-histidineGO:01718310.2DPH3, DPH2

Molecular functions related to Diphtheria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NAD+ ADP-ribosyltransferase activityGO:00395010.6PARP6, TNKS, TNKS2, ZC3HAV1, PARP1, PARP12

Products for genes affiliated with Diphtheria

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diphtheria

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet