MCID: DPH001
MIFTS: 59

Diphtheria malady

Infectious diseases category

Summaries for Diphtheria

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Diphtheria is a serious bacterial infection. you can catch it from a person who has the infection and coughs or sneezes. you can also get infected by coming in contact with an object, such as a toy, that has bacteria on it. diphtheria usually affects the nose and throat. symptoms include sore throat swollen glands in the neck fever weakness your doctor will diagnose it based on your signs and symptoms and a lab test. getting treatment for diphtheria quickly is important. if your doctor suspects that you have it, you'll start treatment before the lab tests come back. treatment is with antibiotics. the diphtheria, pertussis, and tetanus (dpt) vaccine can prevent diphtheria, but its protection does not last forever. children need another dose, or booster, at about age 12. then, as adults, they should get a booster every 10 years. diphtheria is very rare in the united states because of the vaccine. centers for disease control and prevention

MalaCards: Diphtheria, also known as diphtheria, susceptibility to, is related to tetanus and pertussis. An important gene associated with Diphtheria is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are NAD metabolism and Resolution of Abasic Sites (AP sites). The drugs diphtheria antitoxin and equine diphtheria antitoxin and the compounds jw 55 and nu 1025 have been mentioned in the context of this disorder. Affiliated tissues include skin, tonsil and testes.

Disease Ontology:8 A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. a milder form of diphtheria can be restricted to the skin. it is caused by corynebacterium diphtheriae, an aerobic gram-positive bacterium. diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

CDC:3 The page you requested has moved.

Wikipedia:63 Diphtheria (Greek διφθέρα (diphthera) \"pair of leather scrolls\") is an upper respiratory tract... more...

Aliases & Classifications for Diphtheria

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

diphtheria 8 42 46 10 44 48 33 60
diphtheria, susceptibility to 9
corynebacterium infections 60
corynebacterium infection 8


External Ids:

Disease Ontology8 DOID:11405
MeSH34 D003354
MESH via Orphanet35 D004165
ICD10 via Orphanet26 A36.0, A36.1, A36.2 A36.3, A36.8, A36.9, more
SNOMED-CT56 397434007
SNOMED-CT via Orphanet57 397428000
UMLS via Orphanet61 C0012546
ICD1025 A36, A36.9

Related Diseases for Diphtheria

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Diphtheria:



Diseases related to diphtheria

Clinical Features for Diphtheria

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Drugs & Therapeutics for Diphtheria

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diphtheria

Drug clinical trials:

Search ClinicalTrials for Diphtheria

Search NIH Clinical Center for Diphtheria

Search CenterWatch for Diphtheria

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Diphtheria

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Anatomical Context for Diphtheria

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32MalaCards
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MalaCards organs/tissues related to Diphtheria:

32
Skin, Tonsil, Testes, Heart, Kidney, Myeloid, T cells, Breast, B cells, Prostate, Endothelial, Brain, Bone, Lung, Liver, Colon, Smooth muscle, Monocytes, Bone marrow

Animal Models for Diphtheria or affiliated genes

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Publications for Diphtheria

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50PubMed
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Articles related to Diphtheria:

(show top 50)    (show all 739)
idTitleAuthorsYear
1
Diphtheria in a 7-year-old child in north-eastern Nigeria - management in a resource-poor setting. (24249028)
2014
2
Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. (23668887)
2013
3
Postvaccination Miller Fisher syndrome after combined pertussis, diphtheria and tetanus toxoid vaccine. (23219950)
2013
4
Commentary: The evolution of methods to assess the effects of treatments, illustrated by the development of treatments for diphtheria, 1825-1918. (22253300)
2013
5
A truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin. (23470981)
2013
6
Clinical experience of treatment of metastatic melanoma and solid tumours adopting a derivative of diphtheria toxin: cross-reacting material 197. (23422478)
2013
7
Assessment of serologic immunity to diphtheria-tetanus-pertussis after treatment of Korean pediatric hematology and oncology patients. (22219618)
2012
8
Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB). (22513932)
2012
9
The cytotoxic effect of diphtheria toxin on the actin cytoskeleton. (22139586)
2012
10
Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type B. (22357833)
2012
11
A phase III, randomized controlled study to assess the safety and immunogenicity of a semi-synthetic diphtheria, tetanus and whole-cell pertussis vaccine in Indian infants. (22874850)
2012
12
Antibody persistence after primary and booster doses of a pentavalent vaccine against diphtheria, tetanus, acellular pertussis, inactivated poliovirus, haemophilus influenzae type B vaccine among Thai children at 18-19 months of age. (23082595)
2012
13
Diphtheria, tetanus, and pertussis immunity in Indian adults and immunogenicity of td vaccine. (23724309)
2011
14
Spotlight on Tdapa88 vaccine (CovaxisAr) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged a8Y4 years), adolescents, and adults. (21351814)
2011
15
Immunogenicity and reactogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus and Haemophilus influenzae type B. (21621155)
2011
16
Danish contributions to the evaluation of serum therapy for diphtheria in the 1890s. (21558100)
2011
17
The diphtheria vaccine debacle of 1940 that ushered in comprehensive childhood immunization in the United Kingdom. (21226983)
2011
18
Investigation of an outbreak of diphtheria in borborooah block of dibrugarh district, assam. (21031115)
2010
19
Matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry as a tool for rapid diagnosis of potentially toxigenic Corynebacterium species in the laboratory management of diphtheria-associated bacteria. (21087580)
2010
20
Tdap5 vaccine (Covaxis): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged 4 years), adolescents, and adults. (21043546)
2010
21
Determinants of the uptake of the full dose of diphtheria-pertussis-tetanus vaccines (DPT3) in Northern Nigeria: a multilevel analysis. (18607704)
2009
22
The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape during gene transfection. (18930314)
2009
23
Pertussis immunity and response to tetanus-reduced diphtheria-reduced pertussis vaccine (Tdap) after autologous peripheral blood stem cell transplantation. (19896077)
2009
24
High tetanus and diphtheria antitoxin concentrations in Finnish adults--time for new booster recommendations? (19596410)
2009
25
Kinetic intermediate reveals staggered pH-dependent transitions along the membrane insertion pathway of the diphtheria toxin T-domain. (19588969)
2009
26
A population-based, postlicensure evaluation of the safety of a combination diphtheria, tetanus, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine in a large managed care organization. (19047220)
2008
27
Licensure of a diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine and guidance for use as a booster dose. (18830212)
2008
28
Investigation of immunity level against diphtheria and reinforcement of immunity by booster vaccination for infection control staff in Okayama prefecture. (18362396)
2008
29
Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines. (18086218)
2008
30
Safety of the 11-valent pneumococcal vaccine conjugated to non-typeable Haemophilus influenzae-derived protein D in the first 2 years of life and immunogenicity of the co-administered hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio virus, Haemophilus influenzae type b and control hepatitis A vaccines. (18602724)
2008
31
A study on determinants of occurrence of complications and fatality among diphtheria cases admitted to ID & BG Hospital of Kolkata. (19127670)
2008
32
The social production of novelty: the diphtheria serotherapy, "herald of the new medicine"]. (18351157)
2007
33
Humoral immunity 5 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine. (17945400)
2007
34
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in SALo Paulo, Brazil. (17906776)
2007
35
How long can we expect pertussis protection to last after the adolescent booster dose of tetanus-diphtheria-pertussis (Tdap) vaccines? (19043506)
2007
36
A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin. (17693455)
2007
37
Levels of diphtheria and tetanus specific IgG of Portuguese adult women, before and after vaccination with adult type Td. Duration of immunity following vaccination. (17565697)
2007
38
No influence of atopic diseases on antibody titres following tetanus, diphtheria and hepatitis B immunisation among adults. (17891427)
2007
39
Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. (16107576)
2005
40
The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. (12668662)
2003
41
The diphtheria toxin transmembrane domain as a pH sensitive membrane anchor for human interleukin-2 and murine interleukin-3. (9876934)
1998
42
Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva. (7752003)
1995
43
Cutaneous diphtheria in a homeless man. (7651047)
1995
44
Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. (7836353)
1995
45
Brown-SAcquard syndrome following diphtheria and tetanus vaccines. (8009620)
1994
46
A case of cutaneous diphtheria. (1285171)
1992
47
Transverse myelitis after diphtheria, tetanus, and polio immunisation. (861686)
1977
48
The role of cutaneous diphtheria infections in a diphtheria epidemic. (805182)
1975
49
CUTANEOUS diphtheria. (18132812)
1949
50
THE PRESENCE OF DIPHTHERIA BACILLI IN ATROPHIC RHINITIS: [A Preliminary Communication.]. (20760736)
1903

Genetic Variations for Diphtheria

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Expression for genes affiliated with Diphtheria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diphtheria

Search GEO for disease gene expression data for Diphtheria.

Pathways for genes affiliated with Diphtheria

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12EMD Millipore, 53Reactome, 29KEGG, 55SinoBiological, 51QIAGEN
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Pathways related to Diphtheria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
NAD metabolism
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10.5TNKS2, TNKS, PARP1, PARP3, PARP2, PARP4
2
Hide members
10.5PARP1, PARP3, PARP4, PARP2
3
Hide members
10.5PARP1, PARP11, PARP3
410.5TNKS2, TNKS

Compounds for genes affiliated with Diphtheria

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59Tocris Bioscience, 28IUPHAR, 24HMDB, 44Novoseek, 11DrugBank
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Compounds related to Diphtheria according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1jw 555910.8PARP9, PARP11, PARP12, PARP1, TNKS2, TNKS
2nu 10255910.8PARP3, PARP9, PARP11, PARP12, PARP1, TNKS2
3wiki45910.8PARP6, PARP4, PARP14, PARP10, PARP15, PARP2
4nad28 2411.8PARP15, PARP2, PARP8, PARP16, PARP3, PARP9
5xav 9395910.8TNKS2, TNKS, PARP1, PARP12, PARP11, PARP9
6pj 34 hydrochloride5910.7PARP14, PARP4, PARP6, PARP10, PARP15, PARP2
7adpribose4410.6PARP4, TNKS, PARP1, PARP3, PARP2
8nadh44 11 2412.6TNKS, PARP4, PARP2, PARP3, PARP1, TNKS2
9(2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium1110.5PARP2, PARP1
103-aminobenzamide4410.5PARP1, TNKS
11N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE1110.4PARP15, PARP3
12quinazolinone4410.2PARP1, PARP2

GO Terms for genes affiliated with Diphtheria

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16Gene Ontology
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Cellular components related to Diphtheria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.6DPH3, ZC3HAV1, PARP1, PARP12, PARP9, PARP3
2pericentriolar materialGO:00024210.4TNKS2, TNKS
3nuclear chromosome, telomeric regionGO:00078410.2TNKS2, TNKS

Biological processes related to Diphtheria according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1protein ADP-ribosylationGO:00647110.7TNKS2, TIPARP, PARP1, PARP3, PARP2, PARP4
2protein poly-ADP-ribosylationGO:07021210.6PARP1, TNKS, PARP10
3protein auto-ADP-ribosylationGO:07021310.6TNKS, TNKS2
4DNA repairGO:00628110.5PARP1, PARP3, PARP2, PARP4
5positive regulation of telomere maintenance via telomeraseGO:03221210.5TNKS2, TNKS
6protein localization to chromosome, telomeric regionGO:07019810.4TNKS, TNKS2
7peptidyl-diphthamide biosynthetic process from peptidyl-histidineGO:01718310.2DPH3, DPH2

Molecular functions related to Diphtheria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NAD+ ADP-ribosyltransferase activityGO:00395010.6PARP6, TNKS, TNKS2, ZC3HAV1, PARP1, PARP12

Products for genes affiliated with Diphtheria

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diphtheria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet