MCID: DPH001
MIFTS: 59

Diphtheria malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Diphtheria

Aliases & Descriptions for Diphtheria:

Name: Diphtheria 12 50 56 52 41 3 42 14 69
Corynebacterium Infections 42 69
Diphtheria, Susceptibility to 13
Corynebacterium Infection 12

Characteristics:

Orphanet epidemiological data:

56
diphtheria
Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11405
SNOMED-CT 64 397434007
Orphanet 56 ORPHA1679
ICD10 via Orphanet 34 A36.1 A36.2 A36.3 more
MESH via Orphanet 43 D004165
UMLS via Orphanet 70 C0012546
ICD10 33 A36 A36.9
UMLS 69 C0010153

Summaries for Diphtheria

MedlinePlus : 41 diphtheria is a serious bacterial infection. you can catch it from a person who has the infection and coughs or sneezes. you can also get infected by coming in contact with an object, such as a toy, that has bacteria on it. diphtheria usually affects the nose and throat. symptoms include sore throat swollen glands in the neck fever weakness your doctor will diagnose it based on your signs and symptoms and a lab test. getting treatment for diphtheria quickly is important. if your doctor suspects that you have it, you'll start treatment before the lab tests come back. treatment is with antibiotics. the diphtheria, pertussis, and tetanus vaccine can prevent diphtheria, but its protection does not last forever. children need another dose, or booster, at about age 12. then, as adults, they should get a booster every 10 years. diphtheria is very rare in the united states because of the vaccine. centers for disease control and prevention

MalaCards based summary : Diphtheria, also known as corynebacterium infections, is related to tracheitis and rheumatoid arthritis, and has symptoms including coughing, fever and pruritus. An important gene associated with Diphtheria is HBEGF (Heparin Binding EGF Like Growth Factor), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. The drugs Iron and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and kidney, and related phenotypes are Increased viability with SS1P at EC90 and growth/size/body region

Disease Ontology : 12 A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

CDC : 3 Diphtheria once was a major cause of illness and death among children. The United States recorded 206,000 cases of diphtheria in 1921, resulting in 15,520 deaths. Starting in the 1920s, diphtheria rates dropped quickly due to the widespread use of vaccines. Between 2004 and 2015, 2 cases of diphtheria were recorded in the United States. However, the disease continues to cause illness globally. In 2014, 7,321 cases of diphtheria were reported worldwide to the World Health Organization, but many more cases likely go unreported.

Wikipedia : 71 Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae. Signs and symptoms may... more...

Related Diseases for Diphtheria

Diseases related to Diphtheria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
id Related Disease Score Top Affiliating Genes
1 tracheitis 29.3 CD79A IL13 IL2 IL3
2 rheumatoid arthritis 28.7 CD40LG CD79A CSF2 IL2 IL2RA IL2RB
3 cutaneous diphtheria 12.4
4 granulomatous lobular mastitis 10.8
5 diphtheritic peritonitis 10.8
6 pseudomembranous conjunctivitis 10.8
7 tetanus 10.7
8 pertussis 10.7
9 influenza 10.4
10 haemophilus influenzae 10.3
11 hepatitis 10.3
12 hepatitis b 10.3
13 choledochal cyst 10.2 CSF2 IL3
14 non-amyloid monoclonal immunoglobulin deposition disease 10.2 IL2RA IL2RB
15 poliomyelitis 10.2
16 hyperaldosteronism, familial, type ii 10.2 IL2 IL2RA IL2RB
17 retinal ischemia 10.2 CSF2 IL2 IL2RA
18 scarlet fever 10.2
19 barbiturate dependence 10.1 CD79A IL2 IL2RA
20 alcoholic neuropathy 10.1 CD40LG CD79A
21 camptodactyly vertebral fusion 10.1 CD40LG CD79A
22 measles 10.1
23 myiasis 10.1 CD40LG IL2 IL2RA
24 heart conduction disease 10.1 CD40LG IL2 IL2RA
25 leukemia 10.1
26 spinal polio 10.1 CD40LG CD79A
27 rabies 10.1 CD40LG CD79A
28 unilateral retinoblastoma 10.1 CD40LG CD79A
29 mesangial proliferative glomerulonephritis 10.1 CD40LG CD79A
30 cerebral sarcoidosis 10.1 ALB IL2 IL2RA
31 delta chain disease 10.1 CD40LG CD79A
32 atopic dermatitis 6 10.1 ALB CD79A
33 chronic gonococcal salpingitis 10.1 ALB CSF2 IL2
34 discitis 10.1 CD40LG CD79A
35 labyrinthine bilateral reactive loss 10.1 ALB CSF2 IL2
36 spinal canal and spinal cord meningioma 10.1 CD40LG CD79A
37 trichostrongyloidiasis 10.1 CD40LG CD79A
38 liver inflammatory pseudotumor 10.1 ALB EEF2 IL2
39 childhood malignant mesenchymoma 10.1 CSF2 IL13 IL3
40 bile duct adenocarcinoma 10.1 ALB CD40LG
41 heart septal defect 10.1 CD40LG CD79A
42 cutaneous polyarteritis nodosa 10.1 CD40LG CD79A
43 hemangioma of orbit 10.0 CD40LG CD79A IL2
44 hemophagocytic lymphohistiocytosis 10.0 CSF2 IL2 IL2RA IL3
45 mild pre-eclampsia 10.0 CD40LG CD79A
46 tularemia 10.0 CD40LG CD79A IL2
47 retinal microaneurysm 10.0 CD40LG CD79A
48 schneiderian carcinoma 10.0 ALB CD79A
49 newcastle disease 10.0 CD40LG CD79A IL2
50 multinodular goiter 10.0 CD40LG CD79A IL2

Comorbidity relations with Diphtheria via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Diphtheria:



Diseases related to Diphtheria

Symptoms & Phenotypes for Diphtheria

UMLS symptoms related to Diphtheria:


coughing, fever, pruritus, snoring, sore throat, vertigo/dizziness, equilibration disorder

GenomeRNAi Phenotypes related to Diphtheria according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with SS1P at EC90 GR00376-A-1 9.02 DNAJC24 DPH1 DPH2 DPH3 FURIN

MGI Mouse Phenotypes related to Diphtheria:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.21 HBEGF IL13 IL2 IL2RA IL2RB PARP1
2 hematopoietic system MP:0005397 10.06 CD40LG CD79A CD9 CSF2 DPH1 FURIN
3 embryo MP:0005380 10.01 FURIN IL2RB PARP1 CSF2 DNAJC24 DPH1
4 immune system MP:0005387 10 CD40LG CD79A CD9 CSF2 EGF FURIN
5 digestive/alimentary MP:0005381 9.98 ALB DPH1 EGF FURIN IL13 IL2
6 mortality/aging MP:0010768 9.83 ALB CD40LG CSF2 DNAJC24 DPH1 DPH2
7 integument MP:0010771 9.81 PARP1 CD40LG CSF2 DPH1 EGF FURIN
8 respiratory system MP:0005388 9.17 CD9 CSF2 DPH1 HBEGF IL13 IL2

Drugs & Therapeutics for Diphtheria

Drugs for Diphtheria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
2
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Adalimumab Approved Phase 4 331731-18-1 16219006
5
Etanercept Approved, Investigational Phase 4 185243-69-0
6
Daclizumab Approved, Investigational Phase 4 152923-56-3
7
Natalizumab Approved, Investigational Phase 4 189261-10-7
8
Edetic Acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 60-00-4, 62-33-9 6049
9
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
10
Lopinavir Approved Phase 4 192725-17-0 92727
11
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
12
Tenofovir Approved, Investigational Phase 4 147127-20-6 464205
13
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
14 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
15 Aluminum phosphate Phase 4,Phase 3,Phase 1,Phase 2
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
18 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Protective Agents Phase 4,Phase 3,Phase 2
21
Lactitol Phase 4,Phase 3,Phase 2 585-86-4 3871
22 Chelating Agents Phase 4,Phase 3,Phase 2
23 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1
24 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Cyclooxygenase Inhibitors Phase 4
26 PENTA Phase 4,Phase 3,Phase 2
27 Diphtheria Antitoxin Phase 4,Phase 3
28 Pentetic Acid Phase 4,Phase 3,Phase 2
29 Antacids Phase 4,Phase 3,Phase 2,Phase 1
30 Immunoglobulin G Phase 4
31 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Anti-HIV Agents Phase 4,Phase 1
33 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Antibodies, Monoclonal Phase 4,Phase 2
35 Immunosuppressive Agents Phase 4,Phase 2
36 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
37 Anticoagulants Phase 4,Phase 3,Phase 2
38 Antidotes Phase 4,Phase 3,Phase 2
39 Anti-Inflammatory Agents Phase 4,Phase 3
40 Interleukin 1 Receptor Antagonist Protein Phase 4
41 Iron Chelating Agents Phase 4,Phase 3,Phase 2
42 Keyhole-limpet hemocyanin Phase 4,Phase 1
43 Anti-Inflammatory Agents, Non-Steroidal Phase 4
44 Anti-Retroviral Agents Phase 4,Phase 1
45 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2,Phase 1
46 MF59 oil emulsion Phase 4,Phase 2
47 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Antipyretics Phase 4,Phase 3
49 Antirheumatic Agents Phase 4,Phase 2
50 BCG Vaccine Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 523)
id Name Status NCT ID Phase
1 An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster Unknown status NCT00870350 Phase 4
2 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
3 Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine Unknown status NCT00877357 Phase 4
4 The Safety and Immunogenicity of Acellular Pertussis Vaccine in Bone Marrow Transplant Recipients Unknown status NCT00336115 Phase 4
5 Pneumococcal Vaccines Early and in Combination Unknown status NCT01174849 Phase 4
6 Immunogenicity and Safety of BoostrixTM Using a New Syringe in 10 to 15-year Old Adolescents Completed NCT01362322 Phase 4
7 Immunogenicity and Reactogenicity Study of BoostrixTM (dTpa) and Boostrix-IPV (dTpa-IPV) Completed NCT01294605 Phase 4
8 Evaluation of Boostrix™10 Years After Previous Booster Vaccination Completed NCT01147900 Phase 4
9 Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination Completed NCT00548171 Phase 4
10 Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines Completed NCT00254917 Phase 4
11 Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination Completed NCT00244673 Phase 4
12 Immunogenicity and Safety of Concomitant Administration of RotaTeq™ (V260) and the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Healthy Japanese Infants (V260-060) Completed NCT01926015 Phase 4
13 Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE Completed NCT01546909 Phase 4
14 Immunogenicity and Safety of Booster Dose of BoostrixTM Polio Vaccine in Previously Boosted Adults Completed NCT01323959 Phase 4
15 Assess the Safety & Reactogenicity of DTPa-IPV/Hib Vaccine Administered at 3, 4, 5 & 18 Mths of Age, in Healthy Infants Completed NCT00325156 Phase 4
16 Hepatitis B Vaccination in Infants Completed NCT01896596 Phase 4
17 Safety and Immunogenicity in Adults of Revaccination With Adacel® Vaccine 10 Years After a Previous Dose Completed NCT01439165 Phase 4
18 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
19 Retrospective Survey of Safety of Fourth Dose Pentacel® in Children Completed NCT00772369 Phase 4
20 Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand Completed NCT00255021 Phase 4
21 Study of DAPTACEL® Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™ Completed NCT00802867 Phase 4
22 Tdap Vaccine in Post-Partum Women Completed NCT01711645 Phase 4
23 Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination Completed NCT01357720 Phase 4
24 Regulatory Post-Marketing Surveillance Study for TETRAXIM™ Completed NCT01437423 Phase 4
25 Immunogenicity and Safety of TETRAXIM™ Given as a Booster Dose at 4 to 6 Years of Age Completed NCT01031303 Phase 4
26 Safety and Immunogenicity of a Booster Dose of GSK Biological's Boostrix-Polio Vaccine Completed NCT00635128 Phase 4
27 Immunogenicity and Safety Study of a Booster Dose (5th) of Diphteria-Tetanus-Pertussis-Polio Vaccine Completed NCT00514059 Phase 4
28 Post-marketing Evaluation of Reactions Following Receipt of Recommended Adolescent Pertussis Vaccine Completed NCT00304265 Phase 4
29 Immunology of Non-specific Effects of Vaccine Completed NCT00168545 Phase 4
30 Immunogenicity of Adacel® and BOOSTRIX® Vaccines in Adolescents Completed NCT01629589 Phase 4
31 Study of Adacel® Vaccine Administered to Persons 10 Years of Age Completed NCT01311557 Phase 4
32 Post Marketing Surveillance for ADACEL™ in South Korea Completed NCT01137435 Phase 4
33 Immune Responses in Adults to Revaccination With ADACEL® 10 Years After a Previous Dose Completed NCT00712959 Phase 4
34 Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination. Completed NCT00610168 Phase 4
35 A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older Completed NCT00457249 Phase 4
36 Descriptive, Open-label, Multicenter Study of the Safety of Redosing With ADACEL® Vaccine Completed NCT00347958 Phase 4
37 Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX® Completed NCT00319553 Phase 4
38 US-licensed Combined Vaccine Against Tetanus & Diphtheria, Given With US-licensed Vaccine Against Meningococcal Disease Completed NCT00282295 Phase 4
39 Safety of PENTAXIM® Given as a Three-Dose Primary Vaccination at 2, 3, and 4 Months of Age in Infants in China Completed NCT01491087 Phase 4
40 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
41 Safety and Immunogenicity Study of a Liquid Pentavalent Combination Vaccine Completed NCT00617812 Phase 4
42 Phase IV Interchangeability Study of a Liquid Pentavalent Combination Vaccine Completed NCT00674908 Phase 4
43 Comparison of Immunogenicity and Reactogenicity of INFANRIX™ HEXA and HEXAVAC™ Vaccines as a Primary Vaccination Course Completed NCT01457547 Phase 4
44 Study to Evaluate Antibody Persistence in Children Previously Vaccinated With Infanrix Hexa™ or Infanrix-IPV/Hib™ Completed NCT01358825 Phase 4
45 Immunogenicity and Safety of GSK Biologicals' Infanrix Hexa in Infants Completed NCT00753649 Phase 4
46 Study of a New Formulation of DTPa-HBV-IPV/Hib Vaccine Administered as a Booster Dose to 18-23 Months Old Children Completed NCT00611559 Phase 4
47 Canadian Manufactured Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine Compared With U.S. Manufactured Td Completed NCT00601835 Phase 4
48 Maternal Flu Vaccine Trial in Bamako, Mali Completed NCT01430689 Phase 4
49 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
50 A Trial Evaluating a 7-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants. Completed NCT01250756 Phase 4

Search NIH Clinical Center for Diphtheria

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: diphtheria

Genetic Tests for Diphtheria

Anatomical Context for Diphtheria

MalaCards organs/tissues related to Diphtheria:

39
Heart, Skin, Kidney, Testes, Eye, Lymph Node, Tonsil

Publications for Diphtheria

Articles related to Diphtheria:

(show top 50) (show all 868)
id Title Authors Year
1
Demand- and supply-side determinants of diphtheria-pertussis-tetanus nonvaccination and dropout in rural India. ( 28081971 )
2017
2
Augmentation of humoral and cellular immunity in response to Tetanus and Diphtheria toxoids by supercritical carbon dioxide extracts of Hippophae rhamnoides L. leaves. ( 28092864 )
2017
3
Receptor-Mediated Enhanced Cellular Delivery of Nanoparticles Using Recombinant Receptor-Binding Domain of Diphtheria Toxin. ( 27959571 )
2017
4
Life-saving diphtheria drug is running out. ( 28082541 )
2017
5
Impact and cost-effectiveness of a second tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine dose to prevent pertussis in the United States. ( 26899377 )
2016
6
Diphtheria outbreak in Lao People's Democratic Republic, 2012-2013. ( 27422343 )
2016
7
The 1925 Diphtheria Antitoxin Run to Nome - Alaska: A Public Health Illustration of Human-Animal Collaboration. ( 28032302 )
2016
8
Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues. ( 28035954 )
2016
9
Does vaccination ensure protection? Assessing diphtheria and tetanus antibody levels in a population of healthy children: A cross-sectional study. ( 27930568 )
2016
10
Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents. ( 26803328 )
2016
11
Public health action following an outbreak of toxigenic cutaneous diphtheria in an Auckland refugee resettlement centre. ( 28043222 )
2016
12
Safety and immunogenicity of a booster dose of meningococcal (groups A, C, W, and Y) polysaccharide diphtheria toxoid conjugate vaccine. ( 27642132 )
2016
13
Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model. ( 27070129 )
2016
14
Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults. ( 27602049 )
2016
15
Sex-differential effects on mortality of BCG and diphtheria-tetanus-pertussis vaccines in a rural area with high vaccination coverage: observational study from Senegal. ( 27738283 )
2016
16
Genome-Wide Association Mapping of the Antibody Response to Diphtheria-Tetanus-acellular Pertussis Vaccine in Mice. ( 28011915 )
2016
17
Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children. ( 27858500 )
2016
18
Tetanus, diphtheria, and acellular pertussis vaccination among women of childbearing age-United States, 2013. ( 27372388 )
2016
19
Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin. ( 27863545 )
2016
20
Vaccine effectiveness of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine during a pertussis outbreak in Maine. ( 27038131 )
2016
21
Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis. ( 27060790 )
2016
22
Primary cutaneous diphtheria: management, diagnostic workup, and treatment as exemplified by a rare case report. ( 27373251 )
2016
23
A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex. ( 27171114 )
2016
24
Immunogenicity of MenACWY-CRM in Korean Military Recruits: Influence of Tetanus-Diphtheria Toxoid Vaccination on the Vaccine Response to MenACWY-CRM. ( 27593883 )
2016
25
Effect of Tetanus-diphtheria Vaccine on Immune Response to Hepatitis B Vaccine in Low-responder Individuals. ( 27563430 )
2016
26
Immune Thrombocytopenia Following Diphtheria Pertussis- Tetanus and Oral Polio Vaccine. ( 27771689 )
2016
27
High level accumulation of soluble diphtheria toxin mutant (CRM197) with co-expression of chaperones in recombinant Escherichia coli. ( 27020286 )
2016
28
Enhanced surveillance of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines in pregnancy in the Vaccine Adverse Event Reporting System (VAERS), 2011-2015. ( 27013434 )
2016
29
Process optimization for an industrial-scale production of Diphtheria toxin by Corynebacterium diphtheriae PW8. ( 27640957 )
2016
30
Employers' Views on Influenza and Tetanus-Diphtheria-Pertussis Vaccination in the Workplace. ( 27058495 )
2016
31
The safety and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis (dTpa) booster vaccine in healthy Vietnamese children. ( 27435387 )
2016
32
Effect of introduction of pentavalent vaccine as replacement for Diphtheria-Tetanus-Pertussis and Hepatitis B vaccines on vaccination uptake in a health facility in Nigeria. ( 27108191 )
2016
33
Ablation of Pericyte-like Cells in Lungs by Oropharyngeal Aspiration of Diphtheria Toxin. ( 27779900 )
2016
34
Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India. ( 27630847 )
2016
35
Expression and purification of truncated diphtheria toxin, DT386, in Escherichia coli: An attempt for production of a new vaccine against diphtheria. ( 27920826 )
2016
36
Immunological characterization of diphtheria toxin recovered from Corynebacterium pseudotuberculosis. ( 26981011 )
2016
37
Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice. ( 27605621 )
2016
38
Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells Articlefrom Intoxication. ( 27428999 )
2016
39
Impact of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccinations on Reported Pertussis Cases Among Those 11 to 18 Years of Age in an Era of Waning Pertussis Immunity: A Follow-up Analysis. ( 27018748 )
2016
40
Identification and isolation of kidney-derived stem cells from transgenic rats with diphtheria toxin-induced kidney damage. ( 27588086 )
2016
41
Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination. ( 27436422 )
2016
42
Post-licensure safety surveillance study of routine use of tetanus toxoid, reduced diphtheria toxoid and 5-component acellular pertussis vaccine. ( 27388557 )
2016
43
Development of human monoclonal antibodies to diphtheria toxin: a solution for the increasing lack of equine DAT for therapeutic use? ( 27196732 )
2016
44
A Bordetella pertussis proteoliposome induces protection in mice without affecting the immunogenicity of diphtheria and tetanus toxoids in a trivalent formulation. ( 27489808 )
2016
45
Evaluation of the Immunogenicity of Diphtheria Toxoid Conjugated to Salmonella Typhimurium-Derived OPS in a Mouse Model: A Potential Vaccine Candidate Against Salmonellosis. ( 27660722 )
2016
46
Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis. ( 27161783 )
2016
47
Is diphtheria-tetanus-pertussis (DTP) associated with increased female mortality? A meta-analysis testing the hypotheses of sex-differential non-specific effects of DTP vaccine. ( 27856947 )
2016
48
Carrier priming effect of CRM197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM197 and diphtheria toxoid. ( 27015733 )
2016
49
A Phase 2, Randomized, Active-controlled, Observer-blinded Study to Assess the Immunogenicity, Tolerability and Safety of Bivalent rLP2086, a Meningococcal Serogroup B Vaccine, Coadministered With Tetanus, Diphtheria and Acellular Pertussis Vaccine and Serogroup A, C, Y and W-135 Meningococcal Conjugate Vaccine in Healthy US Adolescents. ( 26974889 )
2016
50
Quadracel: Vaccination Against Diphtheria, Tetanus, Pertussis, and Poliomyelitis in Children. ( 27069343 )
2016

Variations for Diphtheria

Expression for Diphtheria

Search GEO for disease gene expression data for Diphtheria.

Pathways for Diphtheria

Pathways related to Diphtheria according to GeneCards Suite gene sharing:

(show all 37)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CD40LG CD79A CSF2 EEF2 EGF HBEGF
2
Show member pathways
13.44 CSF2 EGF FURIN HBEGF IL2 IL2RA
3
Show member pathways
13.35 CD40LG CSF2 EGF IL13 IL2 IL2RA
4
Show member pathways
13.29 CD40LG CSF2 EGF HBEGF IL13 IL2
5
Show member pathways
13.26 ALB CD9 CSF2 EGF IL2 IL2RA
6
Show member pathways
13.19 CD40LG CSF2 EGF HBEGF IL13 IL2
7
Show member pathways
13.01 CD79A EGF HBEGF IL2 IL2RA IL3
8
Show member pathways
12.99 EEF2 EGF HBEGF IL2 IL2RA IL3
9
Show member pathways
12.79 CD40LG IL13 IL2 IL2RA IL3
10
Show member pathways
12.73 FURIN IL13 IL2 IL2RA IL2RB
11 12.52 EGF IL2 IL2RA IL2RB IL3
12 12.48 CD40LG CD79A IL2 IL2RA IL2RB IL3
13 12.37 CSF2 IL2 IL2RA IL2RB
14
Show member pathways
12.33 CD40LG IL2 IL2RA IL2RB
15
Show member pathways
12.08 CSF2 IL2 IL2RA IL2RB IL3
16
Show member pathways
12.04 CSF2 IL13 IL2 IL2RA IL2RB IL3
17 11.85 CD9 CSF2 IL2RA IL3
18 11.83 CD79A EGF HBEGF
19 11.79 EGF IL2RA IL2RB
20 11.76 IL13 IL2 IL2RA IL2RB
21
Show member pathways
11.75 CD9 EEF2 FURIN HBEGF
22 11.74 CSF2 IL13 IL2
23
Show member pathways
11.63 IL2 IL2RA IL2RB
24 11.59 CSF2 EGF IL13
25
Show member pathways
11.59 CD40LG CSF2 IL2
26
Show member pathways
11.57 IL2 IL2RA IL2RB
27
Show member pathways
11.54 CD40LG CSF2 IL2 IL2RA IL3
28 11.5 CD79A CSF2 IL2 IL2RA IL2RB IL3
29 11.43 IL13 IL2 IL2RA IL2RB
30 11.38 EGF IL2 IL2RA IL2RB IL3
31
Show member pathways
11.34 CSF2 IL2 IL2RA IL2RB
32 11.22 CD40LG IL2 IL2RA IL2RB
33 11.2 IL13 IL2 IL2RA
34
Show member pathways
11.16 IL2 IL2RA IL2RB
35 11.16 CD40LG CSF2 IL13 IL2 IL3
36 11.15 CSF2 IL13 IL2 IL3
37
Show member pathways
11.13 DNAJC24 DPH1 DPH2 DPH3 EEF2 FURIN

GO Terms for Diphtheria

Cellular components related to Diphtheria according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ALB CD40LG CSF2 EEF2 EGF FURIN
2 cell surface GO:0009986 9.65 CD40LG CD9 FURIN HBEGF IL2RA
3 extracellular space GO:0005615 9.65 ALB CD40LG CD9 CSF2 EGF FURIN
4 external side of plasma membrane GO:0009897 9.1 CD40LG CD79A CD9 IL13 IL2RA IL2RB

Biological processes related to Diphtheria according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 CSF2 EGF HBEGF IL2 IL3
2 immune response GO:0006955 9.8 CD40LG CSF2 IL13 IL2 IL2RA IL3
3 peptidyl-tyrosine phosphorylation GO:0018108 9.76 CSF2 EGF HBEGF IL3
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.7 EGF HBEGF IL3
5 positive regulation of GTPase activity GO:0043547 9.7 CSF2 EGF HBEGF IL2 IL2RA IL2RB
6 positive regulation of T cell proliferation GO:0042102 9.67 CD40LG IL2 IL2RA
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CSF2 IL2 IL3
8 negative regulation of ERBB signaling pathway GO:1901185 9.54 EGF HBEGF
9 MAPK cascade GO:0000165 9.5 CSF2 EGF HBEGF IL2 IL2RA IL2RB
10 negative regulation of lymphocyte proliferation GO:0050672 9.48 IL2 IL2RA
11 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.43 CSF2 IL2 IL3
12 interleukin-2-mediated signaling pathway GO:0038110 9.4 IL2RA IL2RB
13 regulation of T cell homeostatic proliferation GO:0046013 9.37 IL2 IL2RA
14 peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0017183 9.02 DNAJC24 DPH1 DPH2 DPH3 EEF2

Molecular functions related to Diphtheria according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.67 CSF2 EGF HBEGF IL3
2 cytokine activity GO:0005125 9.55 CD40LG CSF2 IL13 IL2 IL3
3 growth factor activity GO:0008083 9.35 CSF2 EGF HBEGF IL2 IL3
4 interleukin-2 receptor activity GO:0004911 9.32 IL2RA IL2RB
5 interleukin-2 binding GO:0019976 9.26 IL2RA IL2RB
6 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.17 CSF2 EGF HBEGF IL2 IL2RA IL2RB

Sources for Diphtheria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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