MCID: DPH001
MIFTS: 57

Diphtheria

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Diphtheria

MalaCards integrated aliases for Diphtheria:

Name: Diphtheria 12 50 56 52 41 3 42 14 69
Corynebacterium Infections 42 69
Diphtheria, Susceptibility to 13
Corynebacterium Infection 12

Characteristics:

Orphanet epidemiological data:

56
diphtheria
Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11405
SNOMED-CT 64 397434007
Orphanet 56 ORPHA1679
MESH via Orphanet 43 D004165
UMLS via Orphanet 70 C0012546
ICD10 via Orphanet 34 A36.0 A36.1 A36.2 more
ICD10 33 A36 A36.9
UMLS 69 C0010153

Summaries for Diphtheria

MedlinePlus : 41 diphtheria is a serious bacterial infection. you can catch it from a person who has the infection and coughs or sneezes. you can also get infected by coming in contact with an object, such as a toy, that has bacteria on it. diphtheria usually affects the nose and throat. symptoms include sore throat swollen glands in the neck fever weakness your doctor will diagnose it based on your signs and symptoms and a lab test. getting treatment for diphtheria quickly is important. if your doctor suspects that you have it, you'll start treatment before the lab tests come back. treatment is with antibiotics. the diphtheria, pertussis, and tetanus vaccine can prevent diphtheria, but its protection does not last forever. children need another dose, or booster, at about age 12. then, as adults, they should get a booster every 10 years. diphtheria is very rare in the united states because of the vaccine. centers for disease control and prevention

MalaCards based summary : Diphtheria, also known as corynebacterium infections, is related to hemolytic anemia and malaria, and has symptoms including coughing, fever and pruritus. An important gene associated with Diphtheria is HBEGF (Heparin Binding EGF Like Growth Factor), and among its related pathways/superpathways are Metabolism of proteins and Developmental Biology. The drugs Natalizumab and Edetic Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related phenotypes are Increased viability with SS1P at EC90 and growth/size/body region

Disease Ontology : 12 A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

CDC : 3 Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae. Diphtheria causes a thick covering in the back of the throat. It can lead to difficulty breathing, heart failure, paralysis, and even death. Vaccines are recommended for infants, children, teens and adults to prevent diphtheria.

Wikipedia : 72 Diphtheria is an infection caused by the bacterium Corynebacterium diphtheriae. Signs and symptoms may... more...

Related Diseases for Diphtheria

Diseases related to Diphtheria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
id Related Disease Score Top Affiliating Genes
1 hemolytic anemia 28.4 CSF2 IL2 IL2RA IL3
2 malaria 27.3 CSF2 IL13 IL2 IL2RB PLAUR
3 cutaneous diphtheria 12.4
4 granulomatous lobular mastitis 10.8
5 pseudomembranous conjunctivitis 10.8
6 specific antibody deficiency 10.8
7 diphtheritic peritonitis 10.8
8 tetanus 10.7
9 pertussis 10.7
10 opportunistic bacterial infectious disease 10.5 EEF2 HBEGF IL2
11 visual snow syndrome 10.5 IL2 IL2RB
12 graft-versus-host disease, protection against 10.4 IL2 IL2RA
13 influenza 10.4
14 laryngeal papillomatosis 10.4 CSF2 IL2RA
15 alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome 10.3 IL2RA IL2RB
16 haemophilus influenzae 10.3
17 hepatitis 10.3
18 hepatitis b 10.3
19 chronic gonococcal salpingitis 10.2 CSF2 IL2
20 poliomyelitis 10.2
21 scarlet fever 10.2
22 immunodeficiency 11a 10.1 IL2 IL2RA IL2RB
23 measles 10.1
24 sideroblastic anemia 10.1 CSF2 IL3
25 leukemia 10.1
26 renal tubular acidosis 10.1 CSF2 IL2 IL2RA
27 dioctophymiasis 10.0 IL13 IL2
28 cystic adventitial disease 10.0 CSF2 IL3
29 acral lentiginous melanoma 10.0 CSF2 IL2 IL2RA
30 x-linked intellectual disability, van esch type 10.0 IL2 IL3
31 uterine corpus epithelioid leiomyosarcoma 10.0 IL2 IL2RA IL2RB
32 atypical lichen myxedematosus 10.0 IL2RA IL2RB
33 myeloid leukemia 10.0
34 neutropenia, severe congenital 3, autosomal recessive 10.0 CSF2 IL3
35 scleral disease 10.0 IL13 IL2 IL2RA
36 zika virus congenital syndrome 9.9 CSF2 EGF IL2
37 neutropenia, severe congenital 1, autosomal dominant 9.9 CSF2 IL3
38 hemoglobin c disease 9.9 IL2 IL2RA IL3
39 mumps 9.9
40 rubella 9.9
41 endocarditis 9.8
42 myocarditis 9.8
43 glioblastoma 9.8
44 lymphangiectasia, intestinal 9.8 CSF2 IL3
45 neuronitis 9.7
46 pancreatic cancer 9.7
47 melanoma 9.7
48 hepatitis a 9.7
49 mucositis 9.7
50 pancreatitis 9.7

Comorbidity relations with Diphtheria via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Diphtheria:



Diseases related to Diphtheria

Symptoms & Phenotypes for Diphtheria

UMLS symptoms related to Diphtheria:


coughing, fever, pruritus, snoring, sore throat, vertigo/dizziness, equilibration disorder

GenomeRNAi Phenotypes related to Diphtheria according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with SS1P at EC90 GR00376-A-1 9.02 DNAJC24 DPH1 DPH2 DPH3 FURIN

MGI Mouse Phenotypes related to Diphtheria:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.27 CD9 CSF2 DNAJC24 DPH1 DPH3 EEF2
2 embryo MP:0005380 10.06 CSF2 DNAJC24 DPH1 DPH3 EEF2 FURIN
3 hematopoietic system MP:0005397 10.02 CD9 CSF2 DPH1 FURIN IL13 IL2
4 immune system MP:0005387 9.96 EGF FURIN IL13 IL2 IL2RA IL2RB
5 mortality/aging MP:0010768 9.8 DNAJC24 DPH1 DPH2 DPH3 EEF2 FURIN
6 integument MP:0010771 9.76 CSF2 DPH1 EGF FURIN HBEGF IL13
7 respiratory system MP:0005388 9.23 IL2RA PLAUR CD9 CSF2 DPH1 HBEGF

Drugs & Therapeutics for Diphtheria

Drugs for Diphtheria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 165)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Natalizumab Approved, Investigational Phase 4 189261-10-7
2
Edetic Acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 60-00-4, 62-33-9 6049
3
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
4
Adalimumab Approved Phase 4 331731-18-1 16219006
5
Etanercept Approved, Investigational Phase 4 185243-69-0
6
Daclizumab Approved, Investigational Phase 4 152923-56-3
7
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
8
Ibuprofen Approved Phase 4 15687-27-1 3672
9
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
10
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
11
Lopinavir Approved Phase 4 192725-17-0 92727
12
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
13
Lactitol Investigational Phase 4,Phase 3,Phase 2 585-86-4 3871
14
BCG vaccine Investigational Phase 4,Phase 2
15 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Aluminum phosphate Phase 4,Phase 3,Phase 1,Phase 2
17 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Protective Agents Phase 4,Phase 3,Phase 2
19 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
20 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Phase 1
25 Antacids Phase 4,Phase 3,Phase 2,Phase 1
26 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Antidotes Phase 4,Phase 3,Phase 2
29 Antitoxins Phase 4,Phase 3
30 Diphtheria Antitoxin Phase 4,Phase 3
31 Tetanus Antitoxin Phase 4,Phase 3
32 Keyhole-limpet hemocyanin Phase 4,Phase 1
33 Anticoagulants Phase 4,Phase 3,Phase 2
34 Calcium, Dietary Phase 4,Phase 3,Phase 2
35 Chelating Agents Phase 4,Phase 3,Phase 2
36 Iron Chelating Agents Phase 4,Phase 3,Phase 2
37 Pentetic Acid Phase 4,Phase 3,Phase 2
38 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
39 PENTA Phase 4,Phase 3,Phase 2
40 Antirheumatic Agents Phase 4,Phase 2
41 Interleukin 1 Receptor Antagonist Protein Phase 4
42 MF59 oil emulsion Phase 4,Phase 2
43 Anti-Inflammatory Agents Phase 4,Phase 3
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4
45 Immunosuppressive Agents Phase 4,Phase 2
46 Antibodies, Monoclonal Phase 4,Phase 2
47 Antipyretics Phase 4,Phase 3
48 Cyclooxygenase Inhibitors Phase 4
49 Anti-HIV Agents Phase 4,Phase 1
50 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 528)

id Name Status NCT ID Phase Drugs
1 An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster Unknown status NCT00870350 Phase 4
2 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
3 The Safety and Immunogenicity of Acellular Pertussis Vaccine in Bone Marrow Transplant Recipients Unknown status NCT00336115 Phase 4
4 Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine Unknown status NCT00877357 Phase 4
5 Diphtheria, Tetanus, Poliomyelitis -Pertussis-Hib Immunisation in Preterm-born Neonates Unknown status NCT02179996 Phase 4
6 Pneumococcal Vaccines Early and in Combination Unknown status NCT01174849 Phase 4 Synflorix;Prevenar13;COMBO
7 Canadian Manufactured Tetanus and Diphtheria Toxoids Adsorbed (Td) Vaccine Compared With U.S. Manufactured Td Completed NCT00601835 Phase 4
8 Immunogenicity and Safety Study of a Booster Dose (5th) of Diphteria-Tetanus-Pertussis-Polio Vaccine Completed NCT00514059 Phase 4 Boostrix polio
9 Immune Responses in Adults to Revaccination With ADACEL® 10 Years After a Previous Dose Completed NCT00712959 Phase 4
10 Immunogenicity and Safety of Concomitant Administration of RotaTeq™ (V260) and the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Healthy Japanese Infants (V260-060) Completed NCT01926015 Phase 4
11 Descriptive, Open-label, Multicenter Study of the Safety of Redosing With ADACEL® Vaccine Completed NCT00347958 Phase 4
12 Phase IV Interchangeability Study of a Liquid Pentavalent Combination Vaccine Completed NCT00674908 Phase 4
13 A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older Completed NCT00457249 Phase 4
14 US-licensed Combined Vaccine Against Tetanus & Diphtheria, Given With US-licensed Vaccine Against Meningococcal Disease Completed NCT00282295 Phase 4
15 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
16 Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX® Completed NCT00319553 Phase 4
17 Safety and Immunogenicity in Adults of Revaccination With Adacel® Vaccine 10 Years After a Previous Dose Completed NCT01439165 Phase 4
18 Study of Adacel® Vaccine Administered to Persons 10 Years of Age Completed NCT01311557 Phase 4
19 Immunogenicity of Adacel® and BOOSTRIX® Vaccines in Adolescents Completed NCT01629589 Phase 4
20 Post-marketing Evaluation of Reactions Following Receipt of Recommended Adolescent Pertussis Vaccine Completed NCT00304265 Phase 4
21 Maternal Flu Vaccine Trial in Bamako, Mali Completed NCT01430689 Phase 4
22 Post Marketing Surveillance for ADACEL™ in South Korea Completed NCT01137435 Phase 4
23 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
24 Evaluation of Immunogenicity and Safety of the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus (DPT-IPV) Vaccine Squarekids™ Co-administered With GSK Biologicals' Human Rotavirus (HRV) Vaccine Rotarix™ (GSK444563) in Healthy Infants Completed NCT02907216 Phase 4
25 Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE Completed NCT01546909 Phase 4
26 Tdap Vaccine in Post-Partum Women Completed NCT01711645 Phase 4
27 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
28 A Trial Evaluating a 7-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants. Completed NCT01250756 Phase 4
29 Regulatory Post-Marketing Surveillance Study for TETRAXIM™ Completed NCT01437423 Phase 4
30 Study of DAPTACEL® Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™ Completed NCT00802867 Phase 4
31 Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination Completed NCT00244673 Phase 4
32 Safety and Immunogenicity Study of a Liquid Pentavalent Combination Vaccine Completed NCT00617812 Phase 4
33 Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines Completed NCT00254917 Phase 4
34 Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination. Completed NCT00610168 Phase 4
35 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
36 Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination Completed NCT01357720 Phase 4
37 Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068) Completed NCT00289913 Phase 4
38 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
39 Immunogenicity and Safety of Booster Dose of BoostrixTM Polio Vaccine in Previously Boosted Adults Completed NCT01323959 Phase 4
40 Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose Completed NCT01823536 Phase 4
41 Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination Completed NCT00548171 Phase 4
42 Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand Completed NCT00255021 Phase 4
43 Evaluation of Boostrix™10 Years After Previous Booster Vaccination Completed NCT01147900 Phase 4
44 Immunogenicity and Safety of TETRAXIM™ Given as a Booster Dose at 4 to 6 Years of Age Completed NCT01031303 Phase 4
45 The Effects of Tysabri Treatment on Vaccination Response and Lymphocyte Subsets in Subjects With Relapsing Forms of Multiple Sclerosis Completed NCT00536120 Phase 4
46 Immunogenicity and Reactogenicity Study of BoostrixTM (dTpa) and Boostrix-IPV (dTpa-IPV) Completed NCT01294605 Phase 4
47 Descriptive, Post-marketing, Surveillance Safety Study of Menactra Vaccine Completed NCT00254995 Phase 4
48 Immunology of Non-specific Effects of Vaccine Completed NCT00168545 Phase 4
49 Immunogenicity and Safety of BoostrixTM Using a New Syringe in 10 to 15-year Old Adolescents Completed NCT01362322 Phase 4
50 Study Evaluating Prevenar Vaccine in Healthy Infants Completed NCT00276107 Phase 4

Search NIH Clinical Center for Diphtheria

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: diphtheria

Genetic Tests for Diphtheria

Anatomical Context for Diphtheria

MalaCards organs/tissues related to Diphtheria:

39
Heart, Kidney, Testes, Skin, Tonsil, Lymph Node, Eye

Publications for Diphtheria

Articles related to Diphtheria:

(show top 50) (show all 889)
id Title Authors Year
1
Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors. ( 28743950 )
2017
2
Co-administration of BCG and Diphtheria-tetanus-pertussis (DTP) Vaccinations May Reduce Infant Mortality More Than the WHO-schedule of BCG First and Then DTP. A Re-analysis of Demographic Surveillance Data From Rural Bangladesh. ( 28784413 )
2017
3
A new mouse line for cell ablation by diphtheria toxin subunit A controlled by a Cre-dependent FLEx switch. ( 28875587 )
2017
4
Tetanus, diphtheria, and acellular pertussis vaccination during pregnancy and reduced risk of infant acute respiratory infections. ( 28916245 )
2017
5
Diphtheria vaccine: WHO position paper, August 2017 - Recommendations. ( 28822645 )
2017
6
Resurgence of Diphtheria in North Kerala, India, 2016: Laboratory Supported Case-Based Surveillance Outcomes. ( 28913330 )
2017
7
Negative Correlation between Circulating CD4(+)FOXP3(+)CD127(-) Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria-Tetanus-Pertussis Vaccine Implies a Regulatory Role. ( 28855899 )
2017
8
Augmentation of humoral and cellular immunity in response to Tetanus and Diphtheria toxoids by supercritical carbon dioxide extracts of Hippophae rhamnoides L. leaves. ( 28092864 )
2017
9
Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain. ( 28937631 )
2017
10
Post-licensure safety surveillance study of routine use of quadrivalent meningococcal diphtheria toxoid conjugate vaccine. ( 28941623 )
2017
11
Committee Opinion No. 718: Update on Immunization and Pregnancy: Tetanus, Diphtheria, and Pertussis Vaccination. ( 28832489 )
2017
12
Life-saving diphtheria drug is running out. ( 28082541 )
2017
13
Using the 4 Pillarsa8c Practice Transformation Program to increase adolescent human papillomavirus, meningococcal, tetanus-diphtheria-pertussis and influenza vaccination. ( 28947346 )
2017
14
Committee Opinion No. 718 Summary: Update on Immunization and Pregnancy: Tetanus, Diphtheria, and Pertussis Vaccination. ( 28832480 )
2017
15
Diphtheria, pertussis, and tetanus: evidence-based management of pediatric patients in the emergency department ( 28749121 )
2017
16
Receptor-Mediated Enhanced Cellular Delivery of Nanoparticles Using Recombinant Receptor-Binding Domain of Diphtheria Toxin. ( 27959571 )
2017
17
Human liver chimeric mouse model based on diphtheria toxin-induced liver injury. ( 28785147 )
2017
18
Diphtheria, pertussis, and tetanus: evidence-based management of pediatric patients in the emergency department [digest]. ( 28749625 )
2017
19
Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria. ( 28933665 )
2017
20
Respiratory diphtheria due to Corynebacterium ulcerans transmitted by a companion dog, Italy 2014. ( 28647898 )
2017
21
Demand- and supply-side determinants of diphtheria-pertussis-tetanus nonvaccination and dropout in rural India. ( 28081971 )
2017
22
Diphtheria vaccine: WHO position paper a89 August 2017. ( 28776357 )
2017
23
Subcutaneous diphtheria and tetanus vaccines in children with haemophilia: A pilot study and review of the literature. ( 28780770 )
2017
24
Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues. ( 28035954 )
2016
25
Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination. ( 27436422 )
2016
26
Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice. ( 27605621 )
2016
27
Potency of a human monoclonal antibody to diphtheria toxin relative to equine diphtheria anti-toxin in a guinea pig intoxication model. ( 27070129 )
2016
28
State of inequality in diphtheria-tetanus-pertussis immunisation coverage in low-income and middle-income countries: a multicountry study of household health surveys. ( 27497954 )
2016
29
Safety and immunogenicity of a booster dose of meningococcal (groups A, C, W, and Y) polysaccharide diphtheria toxoid conjugate vaccine. ( 27642132 )
2016
30
Employers' Views on Influenza and Tetanus-Diphtheria-Pertussis Vaccination in the Workplace. ( 27058495 )
2016
31
Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children. ( 27858500 )
2016
32
A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex. ( 27171114 )
2016
33
Primary cutaneous diphtheria: management, diagnostic workup, and treatment as exemplified by a rare case report. ( 27373251 )
2016
34
Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells Articlefrom Intoxication. ( 27428999 )
2016
35
Impact and cost-effectiveness of a second tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine dose to prevent pertussis in the United States. ( 26899377 )
2016
36
Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis. ( 27060790 )
2016
37
Genome-Wide Association Mapping of the Antibody Response to Diphtheria-Tetanus-acellular Pertussis Vaccine in Mice. ( 28011915 )
2016
38
Identification and isolation of kidney-derived stem cells from transgenic rats with diphtheria toxin-induced kidney damage. ( 27588086 )
2016
39
Recent Outbreaks of Diphtheria in Dibrugarh District, Assam, India. ( 27630847 )
2016
40
The pH-Dependent Trigger in Diphtheria Toxin T Domain Comes with a Safety Latch. ( 27806276 )
2016
41
A Bordetella pertussis proteoliposome induces protection in mice without affecting the immunogenicity of diphtheria and tetanus toxoids in a trivalent formulation. ( 27489808 )
2016
42
Enhanced surveillance of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines in pregnancy in the Vaccine Adverse Event Reporting System (VAERS), 2011-2015. ( 27013434 )
2016
43
The 1925 Diphtheria Antitoxin Run to Nome - Alaska: A Public Health Illustration of Human-Animal Collaboration. ( 28032302 )
2016
44
Immune Thrombocytopenia Following Diphtheria Pertussis- Tetanus and Oral Polio Vaccine. ( 27771689 )
2016
45
Carrier priming effect of CRM197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM197 and diphtheria toxoid. ( 27015733 )
2016
46
Effect of introduction of pentavalent vaccine as replacement for Diphtheria-Tetanus-Pertussis and Hepatitis B vaccines on vaccination uptake in a health facility in Nigeria. ( 27108191 )
2016
47
The safety and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis (dTpa) booster vaccine in healthy Vietnamese children. ( 27435387 )
2016
48
Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents. ( 26803328 )
2016
49
Quadracel: Vaccination Against Diphtheria, Tetanus, Pertussis, and Poliomyelitis in Children. ( 27069343 )
2016
50
Cost-effectiveness analysis of universal maternal immunization with tetanus-diphtheria-acellular pertussis (Tdap) vaccine in Brazil. ( 26899375 )
2016

Variations for Diphtheria

Expression for Diphtheria

Search GEO for disease gene expression data for Diphtheria.

Pathways for Diphtheria

Pathways related to Diphtheria according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 DNAJC24 DPH1 DPH2 DPH3 DPH7 EEF2
2
Show member pathways
13.42 CSF2 EGF FURIN HBEGF IL2 IL2RA
3
Show member pathways
13.33 CSF2 EGF IL13 IL2 IL2RA IL2RB
4
Show member pathways
13.29 CSF2 EGF HBEGF IL13 IL2 IL2RA
5
Show member pathways
13.23 CD9 CSF2 EGF IL2 IL2RA IL2RB
6
Show member pathways
13.17 CSF2 EGF HBEGF IL13 IL2 IL2RA
7
Show member pathways
12.97 EEF2 EGF HBEGF IL2 IL2RA IL3
8
Show member pathways
12.71 FURIN IL13 IL2 IL2RA IL2RB
9 12.45 IL2 IL2RA IL2RB IL3
10 12.34 CSF2 IL2 IL2RA IL2RB
11
Show member pathways
12.06 CSF2 IL2 IL2RA IL2RB IL3
12
Show member pathways
11.89 IL2 IL2RA IL2RB IL3
13
Show member pathways
11.88 IL2 IL2RA IL2RB
14 11.83 CSF2 IL2 IL2RA IL2RB IL3
15 11.81 CD9 CSF2 IL2RA IL3
16 11.78 EGF IL2 IL2RA IL2RB IL3
17 11.72 CSF2 IL13 IL2
18 11.71 IL13 IL2 IL2RA IL2RB
19
Show member pathways
11.68 CSF2 IL2 IL2RA IL3
20
Show member pathways
11.67 CSF2 IL13 IL2 IL2RA IL2RB IL3
21
Show member pathways
11.62 IL2 IL2RA IL2RB
22 11.57 CSF2 EGF IL13
23
Show member pathways
11.55 IL2 IL2RA IL2RB
24
Show member pathways
11.45 CD9 EEF2 FURIN HBEGF TXNRD1
25 11.38 IL13 IL2 IL2RA IL2RB
26 11.25 IL2 IL2RA IL2RB
27
Show member pathways
11.22 CSF2 IL2 IL2RA IL2RB
28
Show member pathways
11.2 DNAJC24 DPH1 DPH2 DPH3 DPH7 EEF2
29 11.16 IL13 IL2 IL2RA
30 11.12 CSF2 IL13 IL2 IL3
31 11.03 CSF2 IL13 IL2 IL3

GO Terms for Diphtheria

Cellular components related to Diphtheria according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 CD9 FURIN HBEGF IL2RA PLAUR
2 extracellular region GO:0005576 9.61 CSF2 EEF2 EGF FURIN HBEGF IL13
3 external side of plasma membrane GO:0009897 9.46 CD9 IL13 IL2RA IL2RB
4 extracellular space GO:0005615 9.23 CD9 CSF2 EGF FURIN HBEGF IL13

Biological processes related to Diphtheria according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 CSF2 EGF HBEGF IL2 IL3
2 immune response GO:0006955 9.88 CSF2 IL13 IL2 IL2RA IL3
3 positive regulation of GTPase activity GO:0043547 9.8 CSF2 EGF HBEGF IL2 IL2RA IL2RB
4 response to ethanol GO:0045471 9.72 EEF2 IL13 IL2
5 peptidyl-tyrosine phosphorylation GO:0018108 9.71 CSF2 EGF HBEGF IL3
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 EGF HBEGF IL3
7 movement of cell or subcellular component GO:0006928 9.63 CD9 IL13 PLAUR
8 positive regulation of T cell differentiation GO:0045582 9.54 IL2 IL2RA
9 negative regulation of ERBB signaling pathway GO:1901185 9.52 EGF HBEGF
10 MAPK cascade GO:0000165 9.5 CSF2 EGF HBEGF IL2 IL2RA IL2RB
11 negative regulation of lymphocyte proliferation GO:0050672 9.43 IL2 IL2RA
12 interleukin-2-mediated signaling pathway GO:0038110 9.37 IL2RA IL2RB
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 CSF2 IL2 IL3
14 regulation of T cell homeostatic proliferation GO:0046013 9.32 IL2 IL2RA
15 peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0017183 9.1 DNAJC24 DPH1 DPH2 DPH3 DPH7 EEF2

Molecular functions related to Diphtheria according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 CSF2 IL13 IL2 IL3
2 protein tyrosine kinase activity GO:0004713 9.62 CSF2 EGF HBEGF IL3
3 growth factor activity GO:0008083 9.35 CSF2 EGF HBEGF IL2 IL3
4 interleukin-2 binding GO:0019976 9.26 IL2RA IL2RB
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.17 CSF2 EGF HBEGF IL2 IL2RA IL2RB
6 interleukin-2 receptor activity GO:0004911 9.16 IL2RA IL2RB

Sources for Diphtheria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
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52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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