MCID: DPH001
MIFTS: 58

Diphtheria malady

Rare diseases, Infectious diseases categories

Summaries for Diphtheria

About this section
Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Diphtheria is a serious bacterial infection. you can catch it from a person who has the infection and coughs or sneezes. you can also get infected by coming in contact with an object, such as a toy, that has bacteria on it. diphtheria usually affects the nose and throat. symptoms include sore throat swollen glands in the neck fever weakness your doctor will diagnose it based on your signs and symptoms and a lab test. getting treatment for diphtheria quickly is important. if your doctor suspects that you have it, you'll start treatment before the lab tests come back. treatment is with antibiotics. the diphtheria, pertussis, and tetanus (dpt) vaccine can prevent diphtheria, but its protection does not last forever. children need another dose, or booster, at about age 12. then, as adults, they should get a booster every 10 years. diphtheria is very rare in the united states because of the vaccine. centers for disease control and prevention

MalaCards: Diphtheria, also known as diphtheria, susceptibility to, is related to tetanus and pertussis. An important gene associated with Diphtheria is HBEGF (heparin-binding EGF-like growth factor), and among its related pathways are Regulation of Telomerase and Resolution of Abasic Sites (AP sites). The drugs diphtheria antitoxin and equine diphtheria antitoxin and the compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and quinazolinone have been mentioned in the context of this disorder. Affiliated tissues include skin, tonsil and testes, and related mouse phenotype mortality/aging.

Disease Ontology:9 A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. a milder form of diphtheria can be restricted to the skin. it is caused by corynebacterium diphtheriae, an aerobic gram-positive bacterium. diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

CDC:4 Diphtheria once was a major cause of illness and death among children. The U.S. recorded 206,000 cases of diphtheria in 1921, resulting in 15,520 deaths. Starting in the 1920s, diphtheria rates dropped quickly in the U.S. and other countries that began widely vaccinating. Between 2004 and 2008, no cases of diphtheria were recorded in the U.S. However, the disease continues to play a role globally. In 2011, 4,887 cases of diphtheria were reported worldwide to the World Health Organization (WHO), but many more cases likely go unreported.

Wikipedia:66 Diphtheria (from Greek: ??????? diphthera, \"pair of leather scrolls\") is an upper respiratory tract... more...

Aliases & Classifications for Diphtheria

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 10diseasecard, 36MeSH, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

diphtheria 9 44 48 11 46 50 35 63
diphtheria, susceptibility to 10
corynebacterium infections 63
corynebacterium infection 9


External Ids:

Disease Ontology9 DOID:11405
MeSH36 D003354
MESH via Orphanet37 D004165
ICD10 via Orphanet27 A36.0, A36.1, A36.2 A36.3, A36.8, A36.9, more
SNOMED-CT59 397434007
SNOMED-CT via Orphanet60 397428000
UMLS via Orphanet64 C0012546
ICD1026 A36, A36.9

Related Diseases for Diphtheria

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Diphtheria:



Diseases related to diphtheria

Symptoms for Diphtheria

About this section

Drugs & Therapeutics for Diphtheria

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Diphtheria

Drug clinical trials:

Search ClinicalTrials for Diphtheria

Search NIH Clinical Center for Diphtheria

Search CenterWatch for Diphtheria

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Diphtheria

About this section

Anatomical Context for Diphtheria

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Diphtheria:

34
Skin, Tonsil, Testes, Heart, Kidney, Myeloid, T cells, Breast, B cells, Prostate, Endothelial, Brain, Bone, Lung, Liver, Colon, Smooth muscle, Monocytes, Bone marrow

Animal Models for Diphtheria or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Diphtheria:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.8DPH3, PARP3, PARP1, PARP2, TIPARP, HBEGF

Publications for Diphtheria

About this section
Sources:
53PubMed
See all sources

Articles related to Diphtheria:

(show top 50)    (show all 734)
idTitleAuthorsYear
1
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
2
The Terminator mouse is a diphtheria toxin-receptor knock-in mouse strain for rapid and efficient enrichment of desired cell lineages. (23739236)
2013
3
Insights into diphthamide, key diphtheria toxin effector. (23645155)
2013
4
Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age. (23966556)
2013
5
Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. (23668887)
2013
6
Comparison of seven commercial enzyme-linked immunosorbent assays for the detection of anti-diphtheria toxin antibodies. (23354678)
2013
7
Development of a diphtheria toxin-based recombinant porcine IL-2 fusion toxin for depleting porcine CD25+ cells. (24055128)
2013
8
Transcriptional targeting of glioblastoma by diphtheria toxin-A driven by both H19 and IGF2-P4 promoters. (22567173)
2012
9
Influenza and tetanus, diphtheria, and acellular pertussis vaccinations during pregnancy. (22495061)
2012
10
Folding of diphtheria toxin T-domain in the presence of amphipols and fluorinated surfactants: Toward thermodynamic measurements of membrane protein folding. (21945883)
2012
11
Assessment of serologic immunity to diphtheria-tetanus-pertussis after treatment of Korean pediatric hematology and oncology patients. (22219618)
2012
12
Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant. (23000120)
2012
13
Pyopericardium followed by constrictive pericarditis due to Corynebacterium diphtheriae. (22402499)
2012
14
Clinician awareness of tetanus-diphtheria vaccination in trauma patients: a questionnaire study. (22587533)
2012
15
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged <12 months --- Advisory Committee on Immunization Practices (ACIP), 2011. (22012116)
2011
16
Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age. (21134456)
2011
17
The effect of vitamin A supplementation and diphtheria-tetanus-pertussis vaccination on parasitaemia in an experimental murine malaria model. (21105844)
2011
18
Targeting head and neck squamous cell carcinoma using a novel fusion toxin-diphtheria toxin/HN-1. (20814829)
2011
19
Enhanced internalization and endosomal escape of dual-functionalized poly(ethyleneimine)s polyplex with diphtheria toxin T and R domains. (20347568)
2010
20
Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa-HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic. (19467896)
2010
21
Severe neuropathy after diphtheria-tetanus-pertussis vaccination in a child carrying a novel frame-shift mutation in the small heat-shock protein 27 gene. (19435728)
2010
22
Endemic diphtheria in Ho Chi Minh City; Viet Nam: a matched case-control study to identify risk factors of incidence. (20937324)
2010
23
Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy. (19609296)
2010
24
Determinants of the uptake of the full dose of diphtheria-pertussis-tetanus vaccines (DPT3) in Northern Nigeria: a multilevel analysis. (18607704)
2009
25
Combined, reduced-antigen content tetanus, diphtheria, and acellular pertussis vaccine (Boostrix): a review of its use as a single-dose booster immunization in individuals aged 10-64 years in the US. (19697967)
2009
26
A study on the protection of hemodialysis patients against diphtheria and tetanus. (20030525)
2009
27
A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. (19528348)
2009
28
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. (17728142)
2008
29
Investigations of 2 cases of diphtheria-like illness due to toxigenic Corynebacterium ulcerans. (18181738)
2008
30
Enacting cultural boundaries in French and German diphtheria serum research. (18831135)
2008
31
Murine monoclonal antibodies neutralizing the cytotoxic activity of diphtheria toxin. (18595529)
2008
32
NMR assignments of cd-HO, a 24 kDa heme oxygenase from Corynebacterium diphtheria. (19636825)
2007
33
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. (17045366)
2007
34
The immunological response of Thai infants to haemophilus influenzae type B polysaccharide-tetanus conjugate vaccine co-administered in the same syringe with locally produced diphtheria-tetanus-pertussis vaccine. (17710973)
2007
35
Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children. (17931753)
2007
36
The social production of novelty: the diphtheria serotherapy, "herald of the new medicine"]. (18351157)
2007
37
Acute myeloid leukemia cells in G0 phase of the cell cycle that are unresponsive to conventional chemotherapy are sensitive to treatment with granulocyte-macrophage colony-stimulating factor/diphtheria toxin fusion proteins. (15102480)
2004
38
The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. (12668662)
2003
39
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. (12006512)
2002
40
Toxicology and pharmacokinetics of DT388-GM-CSF, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony-stimulating factor (GM-CSF) in C57BL/6 mice. (9630457)
1998
41
Localization of a critical diphtheria toxin-binding domain to the C-terminus of the mature heparin-binding EGF-like growth factor region of the diphtheria toxin receptor. (7826391)
1995
42
A case of cutaneous diphtheria. (1285171)
1992
43
Cutaneous diphtheria. (1816125)
1991
44
Crystallization of diphtheria toxin. (1762153)
1991
45
Characterization of the deoxyribonuclease activity of diphtheria toxin. (2318891)
1990
46
Incidence of cutaneous diphtheria in Bangladesh. (6426456)
1983
47
An unusual case of cutaneous diphtheria. (79663)
1978
48
Polyneuritis following cutaneous diphtheria. (14880919)
1951
49
Scarlet fever, diphtheria, measles, and whooping cough in Glasgow from 1916 to 1945. (18120885)
1949
50
Late neuronitis following proved and suspected cutaneous, faucial and wound diphtheria. (20273904)
1946

Variations for Diphtheria

About this section

Expression for genes affiliated with Diphtheria

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Diphtheria

Search GEO for disease gene expression data for Diphtheria.

Pathways for genes affiliated with Diphtheria

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters
See all sources

Compounds for genes affiliated with Diphtheria

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR
See all sources

Compounds related to Diphtheria according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.9PARP1, HBEGF
2quinazolinone469.8PARP2, PARP1
33-aminobenzamide469.5PARP1, TNKS
4Niacinamide259.1TNKS, PARP2, PARP1, PARP3
5adpribose469.1TNKS, PARP2, PARP1, PARP3
6nadh46 25 1211.0PARP3, PARP1, PARP2, TNKS
7wiki4627.3TNKS, PARP3, PARP1, PARP10, PARP16, PARP2
8jw 55627.3PARP6, TNKS, PARP2, PARP16, PARP10, PARP1
9nu 1025627.3PARP3, PARP1, PARP10, PARP16, PARP2, PARP6
10xav 939627.3PARP3, PARP1, PARP10, PARP16, PARP2, PARP6
11pj 34 hydrochloride627.2PARP3, PARP1, TNKS, PARP6, PARP2, PARP16
12nad30 257.7TNKS, TIPARP, PARP6, PARP2, PARP16, PARP10

GO Terms for genes affiliated with Diphtheria

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Diphtheria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057307.9TNKS, PARP2, PARP10, PARP1, DPH3
2nucleusGO:0056347.4TNKS, PARP2, PARP10, PARP1, PARP3, DPH3

Biological processes related to Diphtheria according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1base-excision repairGO:0062849.9PARP1, PARP2
2double-strand break repairGO:0063029.7PARP3, PARP1
3telomere maintenanceGO:0007239.4PARP3, PARP1
4negative regulation of viral genome replicationGO:0450719.3ZC3HAV1, PARP10
5DNA repairGO:0062819.3PARP2, PARP1, PARP3
6protein poly-ADP-ribosylationGO:0702129.1PARP1, PARP10, TNKS
7protein auto-ADP-ribosylationGO:0702138.8TNKS, PARP16, PARP10
8protein ADP-ribosylationGO:0064717.2PARP3, TNKS, TIPARP, PARP2, PARP16, PARP10

Molecular functions related to Diphtheria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.3PARP2, PARP16, PARP10, PARP1, DPH3, ZC3HAV1
2NAD+ ADP-ribosyltransferase activityGO:0039505.9ZC3HAV1, TNKS, TIPARP, PARP6, PARP2, PARP16

Products for genes affiliated with Diphtheria

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diphtheria

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet