MCID: DRF001
MIFTS: 37

Dirofilariasis malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Dirofilariasis

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 48NIH Rare Diseases, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Dirofilariasis:

Name: Dirofilariasis 11 48 54 2 39 13 68
Dirofilaria Infectious Disease 11
 
Infection by Dirofilaria 11

Characteristics:

Orphanet epidemiological data:

54
dirofilariasis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:1082
ICD1030 B74.8
MeSH39 D004184
Orphanet54 ORPHA166291
SNOMED-CT62 73328005
MESH via Orphanet40 D004184
UMLS via Orphanet69 C0012602
ICD10 via Orphanet31 B74.8

Summaries for Dirofilariasis

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NIH Rare Diseases:48 Dirofilariasis refers to infections caused by dirofilaria roundworms. although the natural hosts of these roundworms are dogs, wild canids (such as wolves and foxes) and raccoons, humans can be infected with dirofilaria larvae through mosquito bites. signs and symptoms of dirofilariasis generally include nodules under the skin or lung granulomas (small nodules formed by an inflammatory reaction) which may be asymptomatic. some people with dirofilariasis of the lungs may also experience cough, chest pain, fever, wheezing, chills, and pleural effusion (excess fluid between the tissues that line the lungs and the chest cavity). dirofilariasis is treated with surgical removal of lung granulomas and skin nodules. last updated: 4/27/2016

MalaCards based summary: Dirofilariasis, also known as dirofilaria infectious disease, is related to mumps and relapsing-remitting multiple sclerosis. An important gene associated with Dirofilariasis is UBASH3A (Ubiquitin Associated And SH3 Domain Containing A), and among its related pathways are Effects of Nitric Oxide and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include lung, skin and breast, and related mouse phenotypes are cardiovascular system and cellular.

Disease Ontology:11 A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

CDC:2 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

Wikipedia:71 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Related Diseases for Dirofilariasis

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Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1mumps10.3CD40LG, STAB2
2relapsing-remitting multiple sclerosis10.3CD40LG, STAB2
3cutaneous polyarteritis nodosa10.3CD40LG, HP
4intracranial abscess10.2CTSL, MT-CO1
5dermatophytosis10.2CD40LG, CTSL
6adrenal gland ganglioneuroblastoma10.2CD40LG, MB
7abdominal tuberculosis10.2CD40LG, CTSL, MT-CO1
8nonspecific interstitial pneumonia10.2CD40LG, HP, MT-CO1
9actinic keratosis10.2CD40LG, CTSL, MT-CO1
10mesenteric lymphadenitis10.2CTSL, CUX1
11linear scleroderma10.1PLAT, PLG
12homocystinuria10.1CD40LG, HP
13tonsillar fossa cancer10.1CD40LG, HP
14oculoauricular syndrome10.1CD40LG, MT-CO1
15mucolipidoses10.1CD40LG, PLAT
16central retinal artery occlusion10.0CD40LG, PLG, TPT1
17invasive aspergillosis10.0PLG, UBASH3A
18microscopic breast papilloma10.0CD40LG, MB, TNNI3
19partial sensory epilepsy10.0BRD4, CD40LG
20serous labyrinthitis10.0BRD4, PLG
21lupus erythematosus10.0MB, PLAT, TNNI3
22silent myocardial infarction9.9MB, PLAT, TPT1
23pyrimidine metabolic disorder9.9HP, PLAT, PON1, TNNI3
24adult t-cell leukemia9.9MB, PLAT, TNNI3
25lung cancer9.8
26hepatitis9.8
27filariasis9.8
28histiocytosis9.8
29meningitis9.8
30immunodeficiency due to defect in mapbp-interacting protein9.7CD40LG, HP, MB, MT-CO1, TPT1
31myocardial infarction9.6MB, PLAT, PLG, PON1, TNNI3
32breast cancer9.6
33pulmonary hypertension9.6
34arthritis9.6
35congestive heart failure9.6
36eosinophilic meningitis9.6
37onchocerciasis9.6
38scleritis9.6
39chronic cervicitis9.6
40pneumothorax9.6
41arteriosclerosis9.6
42cervicitis9.6
43transitional cell carcinoma9.6
44dermatitis9.6
45neurilemmoma9.6
46granulomatous dermatitis9.6
47pulmonary coin lesion9.6
48reactive arthritis9.6
49mediastinitis9.6
50fascioliasis9.6

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Symptoms & Phenotypes for Dirofilariasis

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MGI Mouse Phenotypes related to Dirofilariasis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.2CD40LG, HP, MB, MT-CO1, PLAT, PLG
2MP:00053846.6CD40LG, HP, MB, MT-CO1, NSUN2, PLAT

Drugs & Therapeutics for Dirofilariasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Dirofilariasis


Cochrane evidence based reviews: dirofilariasis

Genetic Tests for Dirofilariasis

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Anatomical Context for Dirofilariasis

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MalaCards organs/tissues related to Dirofilariasis:

36
Lung, Skin, Breast, Testes, B cells, Heart, Eye

Publications for Dirofilariasis

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Articles related to Dirofilariasis:

(show top 50)    (show all 403)
idTitleAuthorsYear
1
Ocular dirofilariasis by Dirofilaria immitis in a child in Iran: A case report and review of the literature. (27815230)
2017
2
Intradural Dirofilariasis in a Dog with Chronic Cervical Pain. (27841685)
2017
3
Human pulmonary dirofilariasis masquerading as a mass. (27432058)
2016
4
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. (28000235)
2016
5
Human dirofilariasis in the eyelid caused by Dirofilaria repens: An imported case. (27544021)
2016
6
Subcutaneous and Pulmonary Dirofilariasis with Evidence of Splenic Involvement. (27579206)
2016
7
Periorbital Dirofilariasis: A Rare Case from Western India. (27134918)
2016
8
Periocular dirofilariasis: A case series. (26819190)
2016
9
A rare case of human pulmonary dirofilariasis with a growing pulmonary nodule after migrating infiltration shadows, mimicking primary lung carcinoma. (27015012)
2016
10
Subcutaneous filariasis in India- Possible indication of human Dirofilariasis. (27004586)
2016
11
Human Ocular Dirofilariasis in Hong Kong. (26636400)
2016
12
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space. (27305941)
2016
13
Ocular dirofilariasis: Series of three cases and review of literature. (27080800)
2016
14
Rare case of epididymal dirofilariasis. (26976948)
2016
15
Subcutaneous human Dirofilariasis in Vidarbha. (26275274)
2015
16
Subcutaneous human dirofilariasis. (25566903)
2015
17
Human dirofilariasis: an emerging zoonosis in India. (26064035)
2015
18
Risk factors for human heartworm infections (dirofilariasis) in the South. (25978057)
2015
19
Description of five dirofilariasis cases in South Hungary and review epidemiology of this disease for the country. (26178869)
2015
20
Subconjunctival dirofilariasis caused by Dirofilaria repens: A case report with short review. (26275256)
2015
21
Cutaneous and pulmonary dirofilariasis due to Dirofilaria repens. (25918821)
2015
22
HUMAN SUBCUTANEOUS DIROFILARIASIS - CASE REPORT. (26591641)
2015
23
Dirofilariasis of the breast: Two new cases in Tunisia. (26446746)
2015
24
A Case Report on Oral Subcutaneous Dirofilariasis. (26858848)
2015
25
18-FDG Uptake in Pulmonary Dirofilariasis. (26622926)
2015
26
Subcutaneous Infraorbital Dirofilariasis. (26288429)
2015
27
Subcutaneous dirofilariasis of the eyelid in a 7-month-old infant. (25871532)
2015
28
Human ocular dirofilariasis due to Dirofilaria repens in Sri Lanka. (26706673)
2015
29
Human subcutaneous/ocular dirofilariasis in the Russian Federation and Belarus, 1997-2013. (25722281)
2015
30
Pulmonary dirofilariasis: A diagnostic pitfall in clinical practice. (26526293)
2015
31
Dirofilariasis - an emergent human parasitosis in Romania. (26204187)
2015
32
Human subcutaneous dirofilariasis of forearm an unusual presentation. (25657423)
2015
33
Oral dirofilariasis. (26470974)
2015
34
A rare case of anterior chamber dirofilariasis. (25709276)
2015
35
Dirofilariasis involving the oral cavity: report of the first case from South America. (26108021)
2015
36
Human subcutaneous dirofilariasis caused by Dirofilaria immitis in a Greek adult. (26166816)
2015
37
First detection of human dirofilariasis in South Africa. (25874068)
2015
38
Assessing the Susceptibility Status of Mosquitoes (Diptera: Culicidae) in a Dirofilariasis Focus, Northwestern Iran. (26114140)
2015
39
Human dirofilariasis: A fast emerging zoonosis in India. (26470975)
2015
40
Dirofilariasis by Dirofilaria repens: an imported case and a brief review. (25769814)
2015
41
Dirofilariasis Mimicking an Acute Scrotum. (25626639)
2015
42
Orbital dirofilariasis. (25435754)
2014
43
Microfilaria in human subcutaneous dirofilariasis: a case report. (24783097)
2014
44
Comments in response to the authors of "Human dirofilariasis due to Dirofilaria repens in the Russian Federation-remarks concerning epidemiology". (24923661)
2014
45
Human dirofilariasis due to Dirofilaria repens in the Russian Federation-remarks concerning epidemiology. (24984163)
2014
46
Sac over the sac - a rare case of subcutaneous dirofilariasis over the lacrimal sac area. (25680253)
2014
47
A case of subcutaneous dirofilariasis presenting in the UK: an unexpected finding. (25477048)
2014
48
Subconjunctival dirofilariasis: Case studies with review of literature. (25250234)
2014
49
Thirty cases of human subcutaneous dirofilariasis reported in Rostov-on-Don (Southwestern Russian Federation). (24948573)
2014
50
Pulmonary dirofilariasis in a 59-year-old man. (25168854)
2014

Variations for Dirofilariasis

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Expression for genes affiliated with Dirofilariasis

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Search GEO for disease gene expression data for Dirofilariasis.

Pathways for genes affiliated with Dirofilariasis

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Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8MB, MT-CO1
29.6PLAT, PLG
39.6PLAT, PLG
49.3HP, PLAT, PLG

GO Terms for genes affiliated with Dirofilariasis

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Cellular components related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular exosomeGO:00700627.9CTSL, HP, MB, PLAT, PLG, PON1
2extracellular spaceGO:00056157.8CD40LG, CTSL, HP, PLAT, PLG, PON1

Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:00427309.6PLAT, PLG

Molecular functions related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042529.0CTSL, HP, PLAT, PLG

Sources for Dirofilariasis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet