MCID: DRF001
MIFTS: 38

Dirofilariasis malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Dirofilariasis

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 2CDC, 37MeSH, 66UMLS, 28ICD10, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
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Aliases & Descriptions for Dirofilariasis:

Name: Dirofilariasis 11 46 13 52 2 37 66
Dirofilaria Infectious Disease 11
 
Infection by Dirofilaria 11

Characteristics:

Orphanet epidemiological data:

52
dirofilariasis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:1082
ICD1028 B74.8
MeSH37 D004184
Orphanet52 ORPHA166291
SNOMED-CT60 73328005
ICD10 via Orphanet29 B74.8
MESH via Orphanet38 D004184
UMLS via Orphanet67 C0012602

Summaries for Dirofilariasis

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NIH Rare Diseases:46 Dirofilariasis refers to infections caused by dirofilaria roundworms. although the natural hosts of these roundworms are dogs, wild canids (such as wolves and foxes) and raccoons, humans can be infected with dirofilaria larvae through mosquito bites. signs and symptoms of dirofilariasis generally include nodules under the skin or lung granulomas (small nodules formed by an inflammatory reaction) which may be asymptomatic. some people with dirofilariasis of the lungs may also experience cough, chest pain, fever, wheezing, chills, and pleural effusion (excess fluid between the tissues that line the lungs and the chest cavity). dirofilariasis is treated with surgical removal of lung granulomas and skin nodules. last updated: 4/27/2016

MalaCards based summary: Dirofilariasis, also known as dirofilaria infectious disease, is related to toxocariasis and discharging ear. An important gene associated with Dirofilariasis is UBASH3A (Ubiquitin Associated And SH3 Domain Containing A), and among its related pathways are Effects of nitric oxide and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include lung, skin and breast, and related mouse phenotypes are cellular and cardiovascular system.

Disease Ontology:11 A filariasis that is a zoonotic infection caused by nematodes dirofilaria immitis or dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. the disease manifests as either subcutaneous nodules or pulmonary lesions.

CDC:2 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

Wikipedia:69 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Related Diseases for Dirofilariasis

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Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1toxocariasis29.8BRD4, MB
2discharging ear10.7CD40LG, STAB2
3gangliosidosis10.7CD40LG, STAB2
4eye degenerative disease10.7CD40LG, UBASH3A
5van benthem-driessen-hanveld syndrome10.7CD40LG, HP
6gastric leiomyoma10.7CTSL, MT-CO1
7chorea gravidarum10.7CD40LG, UBASH3A
8lower lip cancer10.7CD40LG, CTSL
9pompholyx10.6CD40LG, HP
10congenital nystagmus10.6CD40LG, MT-CO1
11waldeyer's ring cancer10.6CD40LG, HP
12anal canal paget's disease10.6CD40LG, MB
13partial motor epilepsy10.6BRD4, CD40LG
14corneal neovascularization10.5CTSL, MT-CO1
15substance-induced psychosis10.5CD40LG, PLG
16idiopathic interstitial pneumonia10.5CD40LG, HP, MT-CO1
17extrapulmonary tuberculosis10.5CD40LG, CTSL, MT-CO1
18metagonimiasis10.5CD40LG, CTSL, MT-CO1
19acute frontal sinusitis10.5AMD1, BRD4
20beach ear10.4CD40LG, PLAT
21japanese encephalitis10.4CD40LG, STAB2
22cervical non-keratinizing squamous cell carcinoma10.4BRD4, CTSL
23central cloudy dystrophy of francois10.4MB, TNNI3
24vestibular nystagmus10.4CD40LG, HP, MB
25connective tissue dysplasia spellacy type10.4PLAT, PLG
26lung abscess10.3CD40LG, RET
27complex partial epilepsy10.3CD40LG, HP
28lateral cystocele10.3BRD4, PLG
29pyrimidine metabolic disorder10.3BRD4, CD40LG, TNNI3
30gingival recession10.3MB, TNNI3
31colon carcinoma in situ10.1MB, PLAT, TNNI3
32gemistocytic astrocytoma10.1CD40LG, PLAT, TNNI3
33primary polycythemia10.1CTSL, CUX1
34lujo hemorrhagic fever10.1CD40LG, PLG
35syphilitic encephalitis10.1CD40LG, MT-CO1
36intracranial arteriosclerosis10.1CD40LG, PLG, TPT1
37phagocyte bactericidal dysfunction10.1CTSL, MB, PON1
38subendocardial myocardial infarction10.0MB, PLAT, TPT1
39peripheral artery disease9.9HP, PLAT, PON1, TNNI3
40lung cancer9.9
41hepatitis9.9
42filariasis9.9
43langerhans-cell histiocytosis9.9
44histiocytosis9.9
45meningitis9.9
46eosinophilia9.9
47adrenal rest tumor9.8CD40LG, PLAT, PLG, PON1
48adult respiratory distress syndrome9.8MB, PLAT, PLG, TNNI3
49breast cancer9.7
50pulmonary hypertension9.7

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Symptoms for Dirofilariasis

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Drugs & Therapeutics for Dirofilariasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Dirofilariasis


Cochrane evidence based reviews: dirofilariasis

Genetic Tests for Dirofilariasis

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Anatomical Context for Dirofilariasis

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MalaCards organs/tissues related to Dirofilariasis:

34
Lung, Skin, Breast, Testes, B cells, Heart, Eye

Animal Models for Dirofilariasis or affiliated genes

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MGI Mouse Phenotypes related to Dirofilariasis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053846.6CD40LG, HP, MB, MT-CO1, PLAT, PLG
2MP:00053856.3CD40LG, HP, MB, MT-CO1, PLAT, PLG

Publications for Dirofilariasis

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Articles related to Dirofilariasis:

(show top 50)    (show all 400)
idTitleAuthorsYear
1
Human dirofilariasis in the eyelid caused by Dirofilaria repens: An imported case. (27544021)
2016
2
Human ocular dirofilariasis due to Dirofilaria repens in Sri Lanka. (26706673)
2015
3
Dirofilariasis Mimicking an Acute Scrotum. (25626639)
2015
4
Dirofilariasis - an emergent human parasitosis in Romania. (26204187)
2015
5
Subconjunctival dirofilariasis: Case studies with review of literature. (25250234)
2014
6
Periocular dirofilariasis mimicking lacrimal sac mucocoele. (23895409)
2013
7
Human dirofilariasis due to Dirofilaria repens in Ukraine, an emergent zoonosis: epidemiological report of 1465 cases. (24338324)
2013
8
Periorbital dirofilariasis-clinical and imaging findings: live worm on ultrasound. (23803483)
2013
9
Subcutaneous dirofilariasis. (23023910)
2012
10
Intramuscular dirofilariasis mimicking an orbital metastasis in a patient with breast cancer. (23008795)
2012
11
Pulmonary dirofilariasis in a Caucasian patient with metastasised osteosarcoma in a non-endemic European region. (21081486)
2011
12
Computed tomographic changes associated with the prepatent and early patent phase of dirofilariasis in an experimentally infected dog. (20402396)
2010
13
Canine and feline dirofilariasis. (19086252)
2008
14
Ocular dirofilariasis in Dubai, UAE. (18579995)
2008
15
Dirofilariasis in Argentina: historical review and first report of Dirofilaria immitis in a natural mosquito population. (16310953)
2006
16
Subcutaneous dirofilariasis caused by Dirofilaria immitis mimicking a large epidermal cyst. (16643162)
2006
17
Unusual finding in a nipple discharge of a female dog: dirofilariasis of the breast. (15637669)
2005
18
Human dirofilariasis of the buccal mucosa: a case report. (12653245)
2003
19
Prevalence of canine dirofilariasis in Taiwan. (12590670)
2003
20
Human dirofilariasis in Costa Rica: Dirofilaria immitis in periorbital tissues. (12669355)
2003
21
Human pulmonary dirofilariasis: uncommon cause of pulmonary coin-lesion. (12103396)
2002
22
Human dirofilariasis in Italy: a new case in the spermatic cord. (12404815)
2002
23
Subconjunctival dirofilariasis in India. (11556571)
2001
24
Feline dirofilariasis. (9753799)
1998
25
Description of the occurrence of canine dirofilariasis in the State of Rio de Janeiro, Brazil. (9302414)
1997
26
Human dirofilariasis due to Dirofilaria (Nochtiella) repens: a review of world literature. (8778658)
1995
27
Pulmonary dirofilariasis in man: a new Italian case. Review of the European literature. (9140502)
1994
28
Conjunctival dirofilariasis in British Columbia. (8313223)
1993
29
Feline dirofilariasis. (8421884)
1993
30
Salivary mucocele associated with dirofilariasis in a dog. (1639703)
1992
31
Chylothorax associated with dirofilariasis in a cat. (2211298)
1990
32
Dirofilariasis of the breast. (2566753)
1989
33
Pulmonary dirofilariasis. The largest single-institution experience. (2915565)
1989
34
Human pulmonary dirofilariasis: does diagnosis require thoracotomy? (3355289)
1988
35
Human pulmonary dirofilariasis. (3384627)
1988
36
Clinical effects after heartworm removal from pulmonary arteries using flexible alligator forceps in dogs with common dirofilariasis. (3210484)
1988
37
Lipids in serum, lipoproteins and erythrocyte membranes in canine dirofilariasis by TLC-FID method. (3586455)
1987
38
Human subcutaneous dirofilariasis: a report of 4 new autochthonous cases in Italy and a review of the literature. (4085101)
1985
39
Dirofilariasis presenting as a breast lump (correction) (6498666)
1984
40
Serum total bile acid levels in canine dirofilariasis. (7182632)
1982
41
Central blood volume and lung extravascular thermal volume in dogs with dirofilariasis. (7103171)
1982
42
Intimal lesions of the pulmonary artery in dogs with experimental dirofilariasis. (7436106)
1980
43
Human subcutaneous dirofilariasis in Illinois. (660850)
1978
44
Experimental dirofilariasis in macaques. III. Susceptibility and host responses to Dirofilaria tenuis of raccoons. (816216)
1976
45
Letter: Human pulmonary dirofilariasis: entry method of infective larvae. (238798)
1975
46
Human pulmonary dirofilariasis. (5110572)
1971
47
Dirofilariasis-- an emerging zoonosis? (5389194)
1969
48
Human pulmonary dirofilariasis manifesting as a "coin" lesion. A case report. (6071128)
1967
49
Feline dirofilariasis in Papula. (6007745)
1966
50
Canine dirofilariasis. II. Utilization of a rapid film change technique. (14398841)
1960

Variations for Dirofilariasis

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Expression for genes affiliated with Dirofilariasis

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Search GEO for disease gene expression data for Dirofilariasis.

Pathways for genes affiliated with Dirofilariasis

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Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.9MB, MT-CO1
29.6PLAT, PLG
39.6PLAT, PLG
49.4HP, PLAT, PLG

GO Terms for genes affiliated with Dirofilariasis

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Cellular components related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.7HP, PLG, PON1
2extracellular spaceGO:00056157.7CD40LG, CTSL, HP, PLAT, PLG, PON1
3extracellular exosomeGO:00700627.5CTSL, HP, MB, PLAT, PLG, PON1

Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibrinolysisGO:00427309.6PLAT, PLG

Sources for Dirofilariasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet