MCID: DRF001
MIFTS: 29

Dirofilariasis malady

Infectious category

Summaries for Dirofilariasis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

MalaCards: Dirofilariasis, also known as dirofilaria infectious disease, is related to pulmonary coin lesion and thromboembolism. An important gene associated with Dirofilariasis is NSUN2 (NOP2/Sun RNA methyltransferase family, member 2). Affiliated tissues include skin, lung and heart, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A filariasis that is a zoonotic infection caused by nematodes dirofilaria immitis or dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. the disease manifests as either subcutaneous nodules or pulmonary lesions.

Wikipedia:64 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Aliases & Classifications for Dirofilariasis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
dirofilariasis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

dirofilariasis 8 43 10 49 61
dirofilaria infectious disease 8
infection by dirofilaria 8


External Ids:

Disease Ontology8 DOID:1082
MeSH35 D004184
MESH via Orphanet36 D004184
SNOMED-CT57 73328005
ICD10 via Orphanet26 B74.8
SNOMED-CT via Orphanet58 73328005
UMLS via Orphanet62 C0012602

Related Diseases for Dirofilariasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1pulmonary coin lesion10.4
2thromboembolism10.1
3onchocerciasis10.0
4reactive arthritis10.0
5eosinophilic meningitis10.0
6fascioliasis10.0
7toxocariasis10.0
8arteriosclerosis10.0
9arthritis10.0
10transitional cell carcinoma10.0

Graphical network of diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Clinical Features for Dirofilariasis

Drugs & Therapeutics for Dirofilariasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Dirofilariasis

Drug clinical trials:

Search ClinicalTrials for Dirofilariasis

Search NIH Clinical Center for Dirofilariasis

Search CenterWatch for Dirofilariasis

Genetic Tests for Dirofilariasis

Anatomical Context for Dirofilariasis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Dirofilariasis:

33
Skin, Lung, Heart, Salivary gland, Breast, B cells

Animal Models for Dirofilariasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Dirofilariasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.1UBASH3A, NSUN2

Publications for Dirofilariasis

Sources:
51PubMed
See all sources

Articles related to Dirofilariasis:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
Human dirofilariasis due to Dirofilaria repens in Ukraine, an emergent zoonosis: epidemiological report of 1465 cases. (24338324)
2013
2
Human pulmonary dirofilariasis coexisting with intercostal neurilemmoma: a case report and literature review. (24080016)
2013
3
Ocular and subcutaneous dirofilariasis in a Sri Lankan infant: an environmental hazard caused by dogs and mosquitoes. (23925286)
2013
4
Subcutaneous dirofilariasis. (23023910)
2012
5
Pulmonary dirofilariasis in a Caucasian patient with metastasised osteosarcoma in a non-endemic European region. (21081486)
2011
6
Human pulmonary Dirofilariasis: one more case in Greece suggests that Dirofilaria is a rather common cause of coin lesions in the lungs in endemic areas of Europe. (20378021)
2010
7
Cutaneous dirofilariasis presenting as an eyelid swelling. (19535767)
2009
8
Distribution and ecology of mosquitoes in a focus of dirofilariasis in northwestern Iran, with the first finding of filarial larvae in naturally infected local mosquitoes. (19493192)
2009
9
Wolbachia in Dirofilaria repens, an agent causing human subcutaneous dirofilariasis. (19127968)
2008
10
Ectopic migration of an adult heartworm in a dog with dirofilariasis (case report). (18830057)
2008
11
A case of lacrimal gland dirofilariasis. (17440285)
2007
12
Allergic inflammatory reaction is involved in necrosis of human pulmonary dirofilariasis. (17880530)
2007
13
Human dirofilariasis: raccoon heartworm causing a leg nodule. (17944170)
2007
14
Natural vectors of dirofilariasis in rural and urban areas of the Tuscan region, central Italy. (16739418)
2006
15
A case of subcutaneous dirofilariasis of the eyelid in the South Indian state of Kerala. (15510465)
2004
16
Pulmonary dirofilariasis with serologic study on familial infection with Dirofilaria immitis. (15168778)
2004
17
Human dirofilariasis of the buccal mucosa: a case report. (12653245)
2003
18
Immunoglobulin G antibodies against the endosymbionts of filarial nematodes (Wolbachia) in patients with pulmonary dirofilariasis. (12522059)
2003
19
Human dirofilariasis. (17642982)
2003
20
Pulmonary dirofilariasis--clinicopathological study. (12502905)
2002
21
A case report of human dirofilariasis in Egypt. (12049268)
2002
22
The first Korean case of human pulmonary dirofilariasis. (10817033)
2000
23
Human ocular dirofilariasis in Kerala Southern India. (12583426)
2000
24
Feline dirofilariasis. (9753799)
1998
25
Human pulmonary dirofilariasis: a review. (8731266)
1995
26
Pulmonary dirofilariasis in California. (8470398)
1993
27
Efficacy of milbemycin oxime in chemoprophylaxis of dirofilariasis in cats. (1476307)
1992
28
Pulmonary dirofilariasis. The largest single-hospital experience. (1516414)
1992
29
The optimal condition for peroxidase-anti-peroxidase staining of lung tissues in canine dirofilariasis. (2190034)
1990
30
Fine needle aspiration of retroperitoneal human dirofilariasis with a pseudotumoral presentation. (1967124)
1990
31
Seroepidemiological studies on human pulmonary dirofilariasis in Spain. (2222022)
1990
32
Pulmonary dirofilariasis. The largest single-institution experience. (2915565)
1989
33
Canine spirocercosis and dirofilariasis infection in Papua New Guinea. (3729844)
1986
34
Dirofilariasis in a ferret. (3710876)
1986
35
Pulmonary dirofilariasis in humans--pneumonitis that evolved to a lung nodule. (2878537)
1986
36
Human pulmonary dirofilariasis. Two case reports. (6697724)
1984
37
Dirofilariasis presenting as a breast lump. (6733631)
1984
38
Treatment of canine dirofilariasis: pulmonary thromboembolism caused by thiacetarsamide--microscopic changes. (6881665)
1983
39
Dirofilariasis in a ferret. (7085481)
1982
40
Human subcutaneous dirofilariasis. 1. Two new cases in Venice. Identification of the causal agent as Dirofilaria repens Raillet and Henry, 1911. (6926932)
1982
41
Case report. Pulmonary dirofilariasis in man. (7064993)
1982
42
Blood cellular and biochemical studies in canine dirofilariasis. (7112916)
1982
43
Epidural dirofilariasis causing paraparesis in a dog. (7096178)
1982
44
Dirofilariasis. IV. Glomerulonephropathy induced by Dirofilaria immitis infection. (6452068)
1981
45
Radiographic changes associated with developing dirofilariasis in experimentally infected dogs. (7362127)
1980
46
Early stages of disease of the peripheral pulmonary arteries in canine dirofilariasis. (7436914)
1980
47
Subcutaneous dirofilariasis in Okinawa, Japan. (434315)
1979
48
Experimental occult dirofilariasis in dogs with reference to immunological responses and its relationship to tropical eosinophilia in man. (4617308)
1974
49
Ruptured pulmonary artery in a dog with dirofilariasis. (4721753)
1973
50
Human dirofilariasis. (5241687)
1968

Genetic Variations for Dirofilariasis

Expression for genes affiliated with Dirofilariasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dirofilariasis

Search GEO for disease gene expression data for Dirofilariasis.

Pathways for genes affiliated with Dirofilariasis

Compounds for genes affiliated with Dirofilariasis

GO Terms for genes affiliated with Dirofilariasis

Products for genes affiliated with Dirofilariasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dirofilariasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet