MCID: DRF001
MIFTS: 34

Dirofilariasis malady

Infectious diseases category

Summaries for Dirofilariasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

MalaCards: Dirofilariasis, also known as dirofilaria infectious disease, is related to pulmonary coin lesion and eosinophilia. An important gene associated with Dirofilariasis is NSUN2 (NOP2/Sun RNA methyltransferase family, member 2). Affiliated tissues include lung, skin and breast, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A filariasis that is a zoonotic infection caused by nematodes dirofilaria immitis or dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. the disease manifests as either subcutaneous nodules or pulmonary lesions.

Wikipedia:63 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Aliases & Classifications for Dirofilariasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
dirofilariasis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

dirofilariasis 8 42 10 48 60
dirofilaria infectious disease 8
infection by dirofilaria 8


External Ids:

Disease Ontology8 DOID:1082
MeSH34 D004184
MESH via Orphanet35 D004184
SNOMED-CT56 73328005
ICD10 via Orphanet26 B74.8
SNOMED-CT via Orphanet57 73328005
UMLS via Orphanet61 C0012602

Related Diseases for Dirofilariasis

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17GeneCards, 18GeneDecks
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Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary coin lesion10.2
2eosinophilia10.1
3hepatitis10.1
4histiocytosis10.1
5langerhans-cell histiocytosis10.1
6lung cancer10.1
7meningitis10.1
8onchocerciasis9.9
9reactive arthritis9.9
10eosinophilic meningitis9.9
11fascioliasis9.9
12toxocariasis9.9
13arteriosclerosis9.9
14arthritis9.9
15breast cancer9.9
16congestive heart failure9.9
17filariasis9.9
18hypertension9.9
19lung benign neoplasm9.9
20mediastinitis9.9
21neurilemmoma9.9
22orbital cancer9.9
23osteosarcoma9.9
24pneumothorax9.9
25proteinuria9.9
26scleritis9.9
27transitional cell carcinoma9.9

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Clinical Features for Dirofilariasis

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Drugs & Therapeutics for Dirofilariasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dirofilariasis

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Anatomical Context for Dirofilariasis

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32MalaCards
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MalaCards organs/tissues related to Dirofilariasis:

32
Lung, Skin, Breast, Testes, Eye, Heart, B cells

Animal Models for Dirofilariasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dirofilariasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.1UBASH3A, NSUN2

Publications for Dirofilariasis

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50PubMed
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Articles related to Dirofilariasis:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
Cutaneous dirofilariasis resulting in orchiectomy. (22121881)
2012
2
Human and animal dirofilariasis: the emergence of a zoonotic mosaic. (22763636)
2012
3
A case of subconjunctival dirofilariasis in South India. (22576665)
2012
4
Subcutaneous human dirofilariasis. (23024495)
2011
5
Human ocular infection with Dirofilaria repens (Railliet and Henry, 1911) in an area endemic for canine dirofilariasis. (21633041)
2011
6
Epidemiological aspects of canine dirofilariasis in the north of iran. (22347277)
2011
7
Dirofilariasis: a rare case report. (20061774)
2010
8
Canine and feline dirofilariasis. (19086252)
2008
9
Dirofilariasis in Argentina: historical review and first report of Dirofilaria immitis in a natural mosquito population. (16310953)
2006
10
Human pulmonary dirofilariasis: a case report and review of the recent Japanese literature. (16635097)
2006
11
Pulmonary dirofilariasis mimicking lung tumor with chest wall and mediastinal invasion. (15926098)
2005
12
First two cases of human dirofilariasis recorded in Croatia. (14710638)
2003
13
The first human case of hepatic dirofilariasis. (12378024)
2002
14
Human pulmonary dirofilariasis: report of six cases. (10739166)
1999
15
Human and canine dirofilariasis in Greece. (9802098)
1997
16
Subcutaneous dirofilariasis: single inoculum, multiple worms. (9158057)
1997
17
Human dirofilariasis in Greece: a review of reported cases and a description of a new, subcutaneous case. (8758146)
1996
18
Elusive migratory subcutaneous dirofilariasis. (8708031)
1996
19
Subcutaneous dirofilariasis in Collier County, Florida, USA. (7611540)
1995
20
Myocardial edema and compromised left ventricular function attributable to dirofilariasis and cardiopulmonary bypass in dogs. (7717590)
1995
21
Pulmonary dirofilariasis in man: a new Italian case. Review of the European literature. (9140502)
1994
22
Human subcutaneous dirofilariasis caused by Dirofilaria repens in Ibiza, Spain. (7943564)
1994
23
Pulmonary arterial changes in feline dirofilariasis. (8442329)
1993
24
Salivary mucocele associated with dirofilariasis in a dog. (1639703)
1992
25
Immunodiagnosis of human dirofilariasis by enzyme-linked immunosorbent assay using recombinant DNA-derived fusion protein. (1280663)
1992
26
Pulmonary dirofilariasis causing a solitary lung mass and pleural effusion. (1926037)
1991
27
Chylothorax associated with dirofilariasis in a cat. (2211298)
1990
28
Ophthalmic dirofilariasis. (2393227)
1990
29
Dirofilariasis in Australia: unusual cause of a breast lump. (2764832)
1989
30
Lipids in serum, lipoproteins and erythrocyte membranes in canine dirofilariasis by TLC-FID method. (3586455)
1987
31
Human dirofilariasis of the bladder. (3981722)
1985
32
Dirofilariasis of human. (6672146)
1983
33
Clinical presentations of canine dirofilariasis with relation to their haematological and microfilarial status. (6665321)
1983
34
Central blood volume and lung extravascular thermal volume in dogs with dirofilariasis. (7103171)
1982
35
Human pulmonary dirofilariasis mimicking metastatic disease. (7326843)
1981
36
Intimal lesions of the pulmonary artery in dogs with experimental dirofilariasis. (7436106)
1980
37
Human dirofilariasis in Japan. Case report and review of literature. (7251254)
1980
38
Dirofilariasis in a cat. (7366578)
1980
39
The use of alpha blockade in the treatment of congestive heart failure associated with dirofilariasis and mitral valvular incompetence. (452344)
1979
40
Canine dirofilariasis in the metropolitan area of Brisbane. (533494)
1979
41
Dirofilariasis in Iowa coyotes. (933306)
1976
42
Human ocular dirofilariasis in Israel. (931717)
1976
43
Experimental dirofilariasis in macaques. II. Susceptibility and host responses to Dirofilaria repens of dogs and cats. (816215)
1976
44
Levamisole as a microfilaricidal agent in the control of canine dirofilariasis. (1167138)
1975
45
Human pulmonary dirofilariasis. A case report and review of the literature. (1163896)
1975
46
Canine dirofilariasis in Iowa. (4412299)
1974
47
Pulmonary dirofilariasis--a case in Western Australia. (4400158)
1971
48
Human pulmonary dirofilariasis in Queensland. (5167525)
1971
49
Pulmonary collateral circulation in canine dirofilariasis. (5824901)
1969
50
Canine dirofilariasis. II. Utilization of a rapid film change technique. (14398841)
1960

Genetic Variations for Dirofilariasis

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Expression for genes affiliated with Dirofilariasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dirofilariasis

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Pathways for genes affiliated with Dirofilariasis

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Compounds for genes affiliated with Dirofilariasis

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GO Terms for genes affiliated with Dirofilariasis

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Products for genes affiliated with Dirofilariasis

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Sources for Dirofilariasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet