MCID: DRF001
MIFTS: 39

Dirofilariasis malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Dirofilariasis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 2CDC, 65UMLS, 27ICD10, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Dirofilariasis:

Name: Dirofilariasis 10 45 12 51 36 2 65
Dirofilaria Infectious Disease 10
 
Infection by Dirofilaria 10

Characteristics:

Orphanet epidemiological data:

51
dirofilariasis:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Disease Ontology10 DOID:1082
ICD1027 B74.8
MeSH36 D004184
Orphanet51 166291
SNOMED-CT59 73328005
ICD10 via Orphanet28 B74.8
MESH via Orphanet37 D004184
UMLS via Orphanet66 C0012602
UMLS65 C0012602

Summaries for Dirofilariasis

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NIH Rare Diseases:45 Dirofilariasis refers to infections caused by dirofilaria roundworms. although the natural hosts of these roundworms are dogs, wild canids (such as wolves and foxes) and raccoons, humans can be infected with dirofilaria larvae through mosquito bites. signs and symptoms of dirofilariasis generally include nodules under the skin or lung granulomas (small nodules formed by an inflammatory reaction) which may be asymptomatic. some people with dirofilariasis of the lungs may also experience cough, chest pain, fever, wheezing, chills, and pleural effusion (excess fluid between the tissues that line the lungs and the chest cavity). dirofilariasis is treated with surgical removal of lung granulomas and skin nodules. last updated: 4/27/2016

MalaCards based summary: Dirofilariasis, also known as dirofilaria infectious disease, is related to breast cancer and hepatitis. An important gene associated with Dirofilariasis is NSUN2 (NOP2/Sun RNA Methyltransferase Family Member 2), and among its related pathways are Fructose metabolism and Citrate cycle (TCA cycle). Affiliated tissues include skin, lung and liver.

Disease Ontology:10 A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

CDC:2 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

Wikipedia:68 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Related Diseases for Dirofilariasis

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Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Symptoms for Dirofilariasis

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Drugs & Therapeutics for Dirofilariasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Dirofilariasis


Cochrane evidence based reviews: dirofilariasis

Genetic Tests for Dirofilariasis

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Anatomical Context for Dirofilariasis

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MalaCards organs/tissues related to Dirofilariasis:

33
Skin, Lung, Liver, Breast, Thyroid, Monocytes, T cells

Animal Models for Dirofilariasis or affiliated genes

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MGI Mouse Phenotypes related to Dirofilariasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Dirofilariasis

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Articles related to Dirofilariasis:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Autoimmune Hemolytic Anemia and Hodgkin's Disease: An Unusual Pediatric Association. (26904342)
2016
2
RISK OF RETINAL VEIN OCCLUSION IN PATIENTS WITH PSORIASIS: A Population-Based Cohort Study. (25856017)
2015
3
Response to: 'Risk of vascular disease with gout: overadjustment of the statistical analyses?' by van Durme et al. (25351520)
2014
4
Efficacy of acotiamide in combination with esomeprazole for functional dyspepsia refractory to proton-pump inhibitor monotherapy. (25382232)
2014
5
HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic fibrosis mutant F508del-CFTR. (23148778)
2013
6
Video-assisted thoracoscopic right lower lobectomy for lung cancer using the Harmonic scalpel. (24409368)
2013
7
Suicide, alcoholism, and psychiatric illness among union forces during the U.S. Civil War. (22853869)
2012
8
Psychoeducational characteristics of children with hypohidrotic ectodermal dysplasia. (22536143)
2012
9
Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements. (20817676)
2011
10
1H-MRS for the diagnosis of acute disseminated encephalomyelitis: insight into the acute-disease stage. (19847418)
2010
11
Reasons for and management of postvitrectomy vitreous hemorrhage in proliferative diabetic retinopathy. (20373898)
2010
12
Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination. (19297308)
2009
13
Long-term outcomes of surgery for malignant sacrococcygeal teratoma: 20-year experience of a regional UK centre. (19184053)
2009
14
Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice. (19656388)
2009
15
Chronic sequelae of herpes simplex encephalitis demonstrated on interictal F-18 FDG PET/CT. (18496462)
2008
16
Claudin-7 expression in human epithelial ovarian cancer. (18298564)
2008
17
Protein kinases and addiction. (18991950)
2008
18
Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. (17855623)
2008
19
Mechanisms of homomeric alpha1 glycine receptor endocytosis. (17887775)
2007
20
Methoxypolyethylene glycol-block-polycaprolactone diblock copolymers reduce P-glycoprotein efflux in the absence of a membrane fluidization effect while stimulating P-glycoprotein ATPase activity. (17094135)
2007
21
Oral methylphenidate fails to elicit significant changes in extracellular putaminal dopamine levels in Parkinson's disease patients: positron emission tomographic studies. (16570297)
2006
22
Understanding and treating kleptomania: new models and new treatments. (16910369)
2006
23
Heterogeneous basis of the type VIB form of Ehlers-Danlos syndrome (EDS VIB) that is unrelated to decreased collagen lysyl hydroxylation. (15523625)
2004
24
Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. (15057744)
2004
25
Clinical outcome of lymphoma patients after idiotype vaccination is correlated with humoral immune response and immunoglobulin G Fc receptor genotype. (15483014)
2004
26
Crystal structure of family GH-8 chitosanase with subclass II specificity from Bacillus sp. K17. (15465062)
2004
27
The first case of intraperitoneal bronchogenic cyst in Korea mimicking a gallbladder tumor. (15201519)
2004
28
C-kit expression in sarcomatoid renal cell carcinoma: potential therapy with imatinib. (15126780)
2004
29
A pilot study of use of the cyclooxygenase-2 inhibitor celecoxib in recurrent prostate cancer after definitive radiation therapy or radical prostatectomy. (14764122)
2004
30
Technology evaluation: APC-8015, Dendreon. (11883698)
2002
31
The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population]. (12509909)
2002
32
Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. (11397774)
2001
33
Hepatobiliary scintigraphic findings in obstructed intrahepatic choledochal cyst before and after surgery. (11290894)
2001
34
Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach. (10961432)
2000
35
Mutational analysis in Lebanese patients with congenital adrenal hyperplasia due to a deficit in 21-hydroxylase. (10971093)
2000
36
Catalase transfection decreases hydrogen peroxide toxicity in a pancreatic beta cell line. (9553756)
1998
37
Chemokines in the gastric mucosa in Helicobacter pylori infection. (9659152)
1998
38
Expression of G1-->S transition regulatory molecules in human urothelial cancer. (9738978)
1998
39
Novel splicing of an IGF2 polymorphic region in human adrenocortical carcinomas. (9367863)
1997
40
Cortisol and TGF-beta inhibit secretion of platelet-activating factor-acetylhydrolase in a monocyte-macrophage model system [corrected]. (9433916)
1997
41
Plasma free thyroxine (FT4) concentrations during hemodialysis in patients with chronic renal failure: effects of plasma non-esterified fatty acids on FT4 measurement. (8980887)
1996
42
Targeting presequence acquisition after mitochondrial gene transfer to the nucleus occurs by duplication of existing targeting signals. (8978691)
1996
43
Orbital pseudotumor as a presenting sign of temporal arteritis. (7554567)
1995
44
Recombinant human leukemia inhibitory factor does not enhance in vitro human blastocyst formation. (7589650)
1995
45
BON cells display the intestinal pattern of neurotensin/neuromedin N precursor processing. (7800856)
1994
46
Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone. (8448065)
1993
47
Purification and characterization of a 90 kDa protein released from human tumors and tumor cell lines. (8454062)
1993
48
Chromosome localization of human ARH genes, a ras-related gene family. (2407642)
1990
49
Epiglottitis. (3352993)
1988
50

Variations for Dirofilariasis

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Expression for genes affiliated with Dirofilariasis

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Search GEO for disease gene expression data for Dirofilariasis.

Pathways for genes affiliated with Dirofilariasis

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Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4ALDOA, ALDOB
2
Show member pathways
9.4ALDOA, ALDOB
3
Show member pathways
9.4ALDOA, ALDOB
4
Show member pathways
8.6ALDOA, ALDOB, TKT
5
Show member pathways
8.6ALDOA, ALDOB, TKT
6
Show member pathways
8.0ALDOA, ALDOB, STAB2, TKT
7
Show member pathways
7.5ALDOA, ALDOB, MT-CO1, STAB2, TKT

GO Terms for genes affiliated with Dirofilariasis

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Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fructose metabolic processGO:00060009.9ALDOA, ALDOB
2small molecule metabolic processGO:00442818.5ALDOB, STAB2, TKT

Molecular functions related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428029.4ALDOA, ALDOB

Sources for Dirofilariasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet