MCID: DRF001
MIFTS: 37

Dirofilariasis malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Dirofilariasis

Aliases & Descriptions for Dirofilariasis:

Name: Dirofilariasis 12 50 56 3 42 14 69
Dirofilaria Infectious Disease 12
Infection by Dirofilaria 12

Characteristics:

Orphanet epidemiological data:

56
dirofilariasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1082
ICD10 33 B74.8
MeSH 42 D004184
SNOMED-CT 64 73328005
Orphanet 56 ORPHA166291
MESH via Orphanet 43 D004184
UMLS via Orphanet 70 C0012602
ICD10 via Orphanet 34 B74.8
UMLS 69 C0012602

Summaries for Dirofilariasis

NIH Rare Diseases : 50 dirofilariasis refers to infections caused by dirofilaria roundworms. although the natural hosts of these roundworms are dogs, wild canids (such as wolves and foxes) and raccoons, humans can be infected with dirofilaria larvae through mosquito bites. signs and symptoms of dirofilariasis generally include nodules under the skin or lung granulomas (small nodules formed by an inflammatory reaction) which may be asymptomatic. some people with dirofilariasis of the lungs may also experience cough, chest pain, fever, wheezing, chills, and pleural effusion (excess fluid between the tissues that line the lungs and the chest cavity). dirofilariasis is treated with surgical removal of lung granulomas and skin nodules. last updated: 4/27/2016

MalaCards based summary : Dirofilariasis, also known as dirofilaria infectious disease, is related to mumps and relapsing-remitting multiple sclerosis. An important gene associated with Dirofilariasis is UBASH3A (Ubiquitin Associated And SH3 Domain Containing A), and among its related pathways/superpathways are A-beta Pathways: Plaque Formation and APP Metabolism and amb2 Integrin signaling. Affiliated tissues include lung, skin and breast, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

CDC : 3 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

Wikipedia : 71 Dirofilariasis is an infection by parasites in the Dirofilaria... more...

Related Diseases for Dirofilariasis

Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 mumps 10.3 CD40LG STAB2
2 relapsing-remitting multiple sclerosis 10.3 CD40LG STAB2
3 cutaneous polyarteritis nodosa 10.3 CD40LG HP
4 intracranial abscess 10.2 CTSL MT-CO1
5 dermatophytosis 10.2 CD40LG CTSL
6 adrenal gland ganglioneuroblastoma 10.2 CD40LG MB
7 abdominal tuberculosis 10.2 CD40LG CTSL MT-CO1
8 nonspecific interstitial pneumonia 10.2 CD40LG HP MT-CO1
9 actinic keratosis 10.2 CD40LG CTSL MT-CO1
10 mesenteric lymphadenitis 10.2 CTSL CUX1
11 linear scleroderma 10.1 PLAT PLG
12 homocystinuria 10.1 CD40LG HP
13 tonsillar fossa cancer 10.1 CD40LG HP
14 oculoauricular syndrome 10.1 CD40LG MT-CO1
15 mucolipidoses 10.1 CD40LG PLAT
16 central retinal artery occlusion 10.0 CD40LG PLG TPT1
17 invasive aspergillosis 10.0 PLG UBASH3A
18 microscopic breast papilloma 10.0 CD40LG MB TNNI3
19 partial sensory epilepsy 10.0 BRD4 CD40LG
20 serous labyrinthitis 10.0 BRD4 PLG
21 lupus erythematosus 10.0 MB PLAT TNNI3
22 silent myocardial infarction 9.9 MB PLAT TPT1
23 pyrimidine metabolic disorder 9.9 HP PLAT PON1 TNNI3
24 adult t-cell leukemia 9.9 MB PLAT TNNI3
25 lung cancer 9.8
26 histiocytosis 9.8
27 hepatitis 9.8
28 filariasis 9.8
29 meningitis 9.8
30 immunodeficiency due to defect in mapbp-interacting protein 9.7 CD40LG HP MB MT-CO1 TPT1
31 myocardial infarction 9.6 MB PLAT PLG PON1 TNNI3
32 dermatitis 9.6
33 neurilemmoma 9.6
34 breast cancer 9.6
35 pulmonary hypertension 9.6
36 granulomatous dermatitis 9.6
37 arthritis 9.6
38 pulmonary coin lesion 9.6
39 congestive heart failure 9.6
40 reactive arthritis 9.6
41 mediastinitis 9.6
42 eosinophilic meningitis 9.6
43 fascioliasis 9.6
44 onchocerciasis 9.6
45 toxocariasis 9.6
46 scleritis 9.6
47 pandas 9.6
48 chronic cervicitis 9.6
49 pneumothorax 9.6
50 arteriosclerosis 9.6

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to Dirofilariasis

Symptoms & Phenotypes for Dirofilariasis

MGI Mouse Phenotypes related to Dirofilariasis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 PLAT PLG PON1 RET STAB2 TKT
2 cellular MP:0005384 9.32 CD40LG HP MB MT-CO1 NSUN2 PLAT

Drugs & Therapeutics for Dirofilariasis

Search Clinical Trials , NIH Clinical Center for Dirofilariasis

Cochrane evidence based reviews: dirofilariasis

Genetic Tests for Dirofilariasis

Anatomical Context for Dirofilariasis

MalaCards organs/tissues related to Dirofilariasis:

39
Lung, Skin, Breast, Testes, Heart, Eye, B Cells

Publications for Dirofilariasis

Articles related to Dirofilariasis:

(show top 50) (show all 403)
id Title Authors Year
1
Ocular dirofilariasis by Dirofilaria immitis in a child in Iran: A case report and review of the literature. ( 27815230 )
2017
2
Intradural Dirofilariasis in a Dog with Chronic Cervical Pain. ( 27841685 )
2017
3
Human pulmonary dirofilariasis masquerading as a mass. ( 27432058 )
2016
4
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. ( 28000235 )
2016
5
Human dirofilariasis in the eyelid caused by Dirofilaria repens: An imported case. ( 27544021 )
2016
6
Subcutaneous and Pulmonary Dirofilariasis with Evidence of Splenic Involvement. ( 27579206 )
2016
7
Periorbital Dirofilariasis: A Rare Case from Western India. ( 27134918 )
2016
8
Periocular dirofilariasis: A case series. ( 26819190 )
2016
9
A rare case of human pulmonary dirofilariasis with a growing pulmonary nodule after migrating infiltration shadows, mimicking primary lung carcinoma. ( 27015012 )
2016
10
Subcutaneous filariasis in India- Possible indication of human Dirofilariasis. ( 27004586 )
2016
11
Human Ocular Dirofilariasis in Hong Kong. ( 26636400 )
2016
12
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space. ( 27305941 )
2016
13
Ocular dirofilariasis: Series of three cases and review of literature. ( 27080800 )
2016
14
Rare case of epididymal dirofilariasis. ( 26976948 )
2016
15
Subcutaneous human Dirofilariasis in Vidarbha. ( 26275274 )
2015
16
Subcutaneous human dirofilariasis. ( 25566903 )
2015
17
Human dirofilariasis: an emerging zoonosis in India. ( 26064035 )
2015
18
Risk factors for human heartworm infections (dirofilariasis) in the South. ( 25978057 )
2015
19
Description of five dirofilariasis cases in South Hungary and review epidemiology of this disease for the country. ( 26178869 )
2015
20
Subconjunctival dirofilariasis caused by Dirofilaria repens: A case report with short review. ( 26275256 )
2015
21
Cutaneous and pulmonary dirofilariasis due to Dirofilaria repens. ( 25918821 )
2015
22
HUMAN SUBCUTANEOUS DIROFILARIASIS - CASE REPORT. ( 26591641 )
2015
23
Dirofilariasis of the breast: Two new cases in Tunisia. ( 26446746 )
2015
24
A Case Report on Oral Subcutaneous Dirofilariasis. ( 26858848 )
2015
25
18-FDG Uptake in Pulmonary Dirofilariasis. ( 26622926 )
2015
26
Subcutaneous Infraorbital Dirofilariasis. ( 26288429 )
2015
27
Subcutaneous dirofilariasis of the eyelid in a 7-month-old infant. ( 25871532 )
2015
28
Human ocular dirofilariasis due to Dirofilaria repens in Sri Lanka. ( 26706673 )
2015
29
Human subcutaneous/ocular dirofilariasis in the Russian Federation and Belarus, 1997-2013. ( 25722281 )
2015
30
Pulmonary dirofilariasis: A diagnostic pitfall in clinical practice. ( 26526293 )
2015
31
Dirofilariasis - an emergent human parasitosis in Romania. ( 26204187 )
2015
32
Human subcutaneous dirofilariasis of forearm an unusual presentation. ( 25657423 )
2015
33
Oral dirofilariasis. ( 26470974 )
2015
34
A rare case of anterior chamber dirofilariasis. ( 25709276 )
2015
35
Dirofilariasis involving the oral cavity: report of the first case from South America. ( 26108021 )
2015
36
Human subcutaneous dirofilariasis caused by Dirofilaria immitis in a Greek adult. ( 26166816 )
2015
37
First detection of human dirofilariasis in South Africa. ( 25874068 )
2015
38
Assessing the Susceptibility Status of Mosquitoes (Diptera: Culicidae) in a Dirofilariasis Focus, Northwestern Iran. ( 26114140 )
2015
39
Human dirofilariasis: A fast emerging zoonosis in India. ( 26470975 )
2015
40
Dirofilariasis by Dirofilaria repens: an imported case and a brief review. ( 25769814 )
2015
41
Dirofilariasis Mimicking an Acute Scrotum. ( 25626639 )
2015
42
Orbital dirofilariasis. ( 25435754 )
2014
43
Microfilaria in human subcutaneous dirofilariasis: a case report. ( 24783097 )
2014
44
Comments in response to the authors of "Human dirofilariasis due to Dirofilaria repens in the Russian Federation-remarks concerning epidemiology". ( 24923661 )
2014
45
Human dirofilariasis due to Dirofilaria repens in the Russian Federation-remarks concerning epidemiology. ( 24984163 )
2014
46
Sac over the sac - a rare case of subcutaneous dirofilariasis over the lacrimal sac area. ( 25680253 )
2014
47
A case of subcutaneous dirofilariasis presenting in the UK: an unexpected finding. ( 25477048 )
2014
48
Subconjunctival dirofilariasis: Case studies with review of literature. ( 25250234 )
2014
49
Thirty cases of human subcutaneous dirofilariasis reported in Rostov-on-Don (Southwestern Russian Federation). ( 24948573 )
2014
50
Pulmonary dirofilariasis in a 59-year-old man. ( 25168854 )
2014

Variations for Dirofilariasis

Expression for Dirofilariasis

Search GEO for disease gene expression data for Dirofilariasis.

Pathways for Dirofilariasis

Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.67 PLAT PLG
2 10.48 HP PLAT PLG
3 10.27 PLAT PLG
4 9.86 MB MT-CO1

GO Terms for Dirofilariasis

Cellular components related to Dirofilariasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.61 CTSL HP MB PLAT PLG PON1
2 extracellular space GO:0005615 9.17 CD40LG CTSL HP PLAT PLG PON1

Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 8.62 PLAT PLG

Molecular functions related to Dirofilariasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.92 CTSL HP PLAT PLG

Sources for Dirofilariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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