MCID: DRF001
MIFTS: 33

Dirofilariasis malady

Rare diseases, Infectious diseases categories

Summaries for Dirofilariasis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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CDC:4 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

MalaCards: Dirofilariasis, also known as dirofilaria infectious disease, is related to langerhans-cell histiocytosis and eosinophilia. An important gene associated with Dirofilariasis is NSUN2 (NOP2/Sun RNA methyltransferase family, member 2). Affiliated tissues include lung, skin and breast.

Disease Ontology:9 A filariasis that is a zoonotic infection caused by nematodes dirofilaria immitis or dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. the disease manifests as either subcutaneous nodules or pulmonary lesions.

Wikipedia:66 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Aliases & Classifications for Dirofilariasis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
dirofilariasis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

dirofilariasis 9 44 11 50 63
dirofilaria infectious disease 9
infection by dirofilaria 9


External Ids:

Disease Ontology9 DOID:1082
MeSH36 D004184
MESH via Orphanet37 D004184
SNOMED-CT59 73328005
ICD10 via Orphanet27 B74.8
SNOMED-CT via Orphanet60 73328005
UMLS via Orphanet64 C0012602

Related Diseases for Dirofilariasis

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18GeneCards, 19GeneDecks
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Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1langerhans-cell histiocytosis10.1
2eosinophilia10.1
3hepatitis10.1
4histiocytosis10.1
5lung cancer10.1
6meningitis10.1
7thromboembolism10.1
8onchocerciasis10.0
9reactive arthritis10.0
10eosinophilic meningitis10.0
11pulmonary coin lesion10.0
12fascioliasis10.0
13toxocariasis10.0
14arteriosclerosis10.0
15arthritis10.0
16breast cancer10.0
17congestive heart failure10.0
18filariasis10.0
19hypertension10.0
20mediastinitis10.0
21neurilemmoma10.0
22osteosarcoma10.0
23pneumothorax10.0
24proteinuria10.0
25scleritis10.0
26transitional cell carcinoma10.0
27pandas10.0

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Symptoms for Dirofilariasis

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Drugs & Therapeutics for Dirofilariasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dirofilariasis

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Anatomical Context for Dirofilariasis

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34MalaCards
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MalaCards organs/tissues related to Dirofilariasis:

34
Lung, Skin, Breast, Testes, Eye, Heart, B cells

Animal Models for Dirofilariasis or affiliated genes

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Publications for Dirofilariasis

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53PubMed
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Articles related to Dirofilariasis:

(show top 50)    (show all 341)
idTitleAuthorsYear
1
Periocular dirofilariasis mimicking lacrimal sac mucocoele. (23895409)
2013
2
Subcutaneous dirofilariasis. (23023910)
2012
3
Intradural dirofilariasis mimicking a Langerhans cell histiocytosis tumor. (19489058)
2009
4
Canine and feline dirofilariasis. (19086252)
2008
5
Ocular dirofilariasis in Dubai, UAE. (18579995)
2008
6
Survey of canine dirofilariasis in Vojvodina, Serbia. (18712415)
2008
7
Dirofilariasis in Argentina: historical review and first report of Dirofilaria immitis in a natural mosquito population. (16310953)
2006
8
Human pulmonary dirofilariasis: a case report and review of the recent Japanese literature. (16635097)
2006
9
Subcutaneous dirofilariasis caused by Dirofilaria immitis mimicking a large epidermal cyst. (16643162)
2006
10
A case of periocular dirofilariasis masquerading as a lid tumour. (15829752)
2005
11
Unusual finding in a nipple discharge of a female dog: dirofilariasis of the breast. (15637669)
2005
12
Human dirofilariasis of the buccal mucosa: a case report. (12653245)
2003
13
Prevalence of canine dirofilariasis in Taiwan. (12590670)
2003
14
Immunoglobulin G antibodies against the endosymbionts of filarial nematodes (Wolbachia) in patients with pulmonary dirofilariasis. (12522059)
2003
15
Human dirofilariasis in Costa Rica: Dirofilaria immitis in periorbital tissues. (12669355)
2003
16
Human pulmonary dirofilariasis: uncommon cause of pulmonary coin-lesion. (12103396)
2002
17
Subconjunctival dirofilariasis in India. (11556571)
2001
18
Pulmonary dirofilariasis in a patient with multisystem Langerhans cell histiocytosis--the first reported case in Thailand. (9737133)
1998
19
The first case report of suspected human dirofilariasis in the eyelid of a patient from Alexandria. (9914714)
1998
20
Description of the occurrence of canine dirofilariasis in the State of Rio de Janeiro, Brazil. (9302414)
1997
21
Subcutaneous dirofilariasis in Collier County, Florida, USA. (7611540)
1995
22
Pulmonary dirofilariasis in man: a new Italian case. Review of the European literature. (9140502)
1994
23
Conjunctival dirofilariasis in British Columbia. (8313223)
1993
24
Feline dirofilariasis. (8421884)
1993
25
Salivary mucocele associated with dirofilariasis in a dog. (1639703)
1992
26
Chylothorax associated with dirofilariasis in a cat. (2211298)
1990
27
Dirofilariasis of the breast. (2566753)
1989
28
Pulmonary dirofilariasis. The largest single-institution experience. (2915565)
1989
29
Human pulmonary dirofilariasis: does diagnosis require thoracotomy? (3355289)
1988
30
Human pulmonary dirofilariasis. (3384627)
1988
31
Clinical effects after heartworm removal from pulmonary arteries using flexible alligator forceps in dogs with common dirofilariasis. (3210484)
1988
32
Lipids in serum, lipoproteins and erythrocyte membranes in canine dirofilariasis by TLC-FID method. (3586455)
1987
33
Dirofilariasis presenting as a breast lump (correction) (6498666)
1984
34
Dirofilariasis with arteriosclerosis in a horse. (6480468)
1984
35
Dirofilariasis in a ferret. (7085481)
1982
36
Human subcutaneous dirofilariasis. 1. Two new cases in Venice. Identification of the causal agent as Dirofilaria repens Raillet and Henry, 1911. (6926932)
1982
37
Serum total bile acid levels in canine dirofilariasis. (7182632)
1982
38
Dirofilariasis. IV. Glomerulonephropathy induced by Dirofilaria immitis infection. (6452068)
1981
39
Dirofilariasis of the breast in france. (7435780)
1980
40
Human subcutaneous dirofilariasis in Illinois. (660850)
1978
41
Electrophoretical studies on serum lipoprotein fractions in canine dirofilariasis. (916460)
1977
42
Experimental dirofilariasis in macaques. III. Susceptibility and host responses to Dirofilaria tenuis of raccoons. (816216)
1976
43
Letter: Human pulmonary dirofilariasis: entry method of infective larvae. (238798)
1975
44
Experimental occult dirofilariasis in dogs with reference to immunological responses and its relationship to tropical eosinophilia in man. (4617308)
1974
45
Ruptured pulmonary artery in a dog with dirofilariasis. (4721753)
1973
46
Human pulmonary dirofilariasis. (5110572)
1971
47
Dirofilariasis-- an emerging zoonosis? (5389194)
1969
48
Human pulmonary dirofilariasis manifesting as a &quot;coin&quot; lesion. A case report. (6071128)
1967
49
Feline dirofilariasis in Papula. (6007745)
1966
50
Canine dirofilariasis. II. Utilization of a rapid film change technique. (14398841)
1960

Variations for Dirofilariasis

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Expression for genes affiliated with Dirofilariasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dirofilariasis

Search GEO for disease gene expression data for Dirofilariasis.

Pathways for genes affiliated with Dirofilariasis

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Compounds for genes affiliated with Dirofilariasis

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GO Terms for genes affiliated with Dirofilariasis

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Products for genes affiliated with Dirofilariasis

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Sources for Dirofilariasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet