MCID: DRF001
MIFTS: 36

Dirofilariasis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Dirofilariasis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 2CDC, 65UMLS, 36MeSH, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Dirofilariasis:

Name: Dirofilariasis 10 45 12 51 2 65 36
Dirofilaria Infectious Disease 10
 
Infection by Dirofilaria 10


Classifications:



Characteristics (Orphanet epidemiological data):

51
dirofilariasis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology10 DOID:1082
MeSH36 D004184
Orphanet51 166291
SNOMED-CT59 73328005
ICD10 via Orphanet28 B74.8
MESH via Orphanet37 D004184
UMLS via Orphanet66 C0012602

Summaries for Dirofilariasis

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CDC:2 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

MalaCards based summary: Dirofilariasis, also known as dirofilaria infectious disease, is related to lung cancer and hepatitis. An important gene associated with Dirofilariasis is NSUN2 (NOP2/Sun RNA Methyltransferase Family, Member 2), and among its related pathways are Citrate cycle (TCA cycle) and Fructose and mannose metabolism. Affiliated tissues include lung, skin and breast.

Disease Ontology:10 A filariasis that is a zoonotic infection caused by nematodes dirofilaria immitis or dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. the disease manifests as either subcutaneous nodules or pulmonary lesions.

Wikipedia:68 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Related Diseases for Dirofilariasis

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Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer10.2
2hepatitis10.2
3langerhans-cell histiocytosis10.2
4eosinophilia10.2
5histiocytosis10.2
6meningitis10.2
7breast cancer10.0
8pulmonary hypertension10.0
9arthritis10.0
10congestive heart failure10.0
11onchocerciasis10.0
12eosinophilic meningitis10.0
13toxocariasis10.0
14reactive arthritis10.0
15pulmonary coin lesion10.0
16fascioliasis10.0
17arteriosclerosis10.0
18filariasis10.0
19mediastinitis10.0
20neurilemmoma10.0
21pneumothorax10.0
22scleritis10.0
23transitional cell carcinoma10.0
24pandas10.0
25aneruptive fever9.8ALDOA, ALDOB
26wernicke encephalopathy8.9ALDOA, ALDOB, AMD1, MT-CO1, NSUN2, TKT

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Symptoms for Dirofilariasis

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Drugs & Therapeutics for Dirofilariasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Dirofilariasis


Cochrane evidence based reviews: Dirofilariasis

Genetic Tests for Dirofilariasis

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Anatomical Context for Dirofilariasis

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MalaCards organs/tissues related to Dirofilariasis:

33
Lung, Skin, Breast, Testes, B cells, Heart, Eye

Animal Models for Dirofilariasis or affiliated genes

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MGI Mouse Phenotypes related to Dirofilariasis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Dirofilariasis

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Articles related to Dirofilariasis:

(show top 50)    (show all 378)
idTitleAuthorsYear
1
Assessing the Susceptibility Status of Mosquitoes (Diptera: Culicidae) in a Dirofilariasis Focus, Northwestern Iran. (26114140)
2015
2
Comments in response to the authors of "Human dirofilariasis due to Dirofilaria repens in the Russian Federation-remarks concerning epidemiology". (24923661)
2014
3
Subconjunctival dirofilariasis: Case studies with review of literature. (25250234)
2014
4
Oral dirofilariasis. (24992859)
2014
5
Dirofilariasis of the breast: sonographic appearance. (24615752)
2014
6
Periocular dirofilariasis mimicking lacrimal sac mucocoele. (23895409)
2013
7
Intradural dirofilariasis mimicking a Langerhans cell histiocytosis tumor. (19489058)
2009
8
Canine and feline dirofilariasis. (19086252)
2008
9
Ocular dirofilariasis in Dubai, UAE. (18579995)
2008
10
Survey of canine dirofilariasis in Vojvodina, Serbia. (18712415)
2008
11
Dirofilariasis in Argentina: historical review and first report of Dirofilaria immitis in a natural mosquito population. (16310953)
2006
12
Human pulmonary dirofilariasis: a case report and review of the recent Japanese literature. (16635097)
2006
13
Subcutaneous dirofilariasis caused by Dirofilaria immitis mimicking a large epidermal cyst. (16643162)
2006
14
A case of periocular dirofilariasis masquerading as a lid tumour. (15829752)
2005
15
Unusual finding in a nipple discharge of a female dog: dirofilariasis of the breast. (15637669)
2005
16
Human dirofilariasis of the buccal mucosa: a case report. (12653245)
2003
17
Prevalence of canine dirofilariasis in Taiwan. (12590670)
2003
18
Immunoglobulin G antibodies against the endosymbionts of filarial nematodes (Wolbachia) in patients with pulmonary dirofilariasis. (12522059)
2003
19
Human dirofilariasis in Costa Rica: Dirofilaria immitis in periorbital tissues. (12669355)
2003
20
Subconjunctival dirofilariasis in India. (11556571)
2001
21
Pulmonary dirofilariasis in a patient with multisystem Langerhans cell histiocytosis--the first reported case in Thailand. (9737133)
1998
22
The first case report of suspected human dirofilariasis in the eyelid of a patient from Alexandria. (9914714)
1998
23
Description of the occurrence of canine dirofilariasis in the State of Rio de Janeiro, Brazil. (9302414)
1997
24
Subcutaneous dirofilariasis in Collier County, Florida, USA. (7611540)
1995
25
Pulmonary dirofilariasis in man: a new Italian case. Review of the European literature. (9140502)
1994
26
Conjunctival dirofilariasis in British Columbia. (8313223)
1993
27
Feline dirofilariasis. (8421884)
1993
28
Salivary mucocele associated with dirofilariasis in a dog. (1639703)
1992
29
Chylothorax associated with dirofilariasis in a cat. (2211298)
1990
30
Dirofilariasis of the breast. (2566753)
1989
31
Pulmonary dirofilariasis. The largest single-institution experience. (2915565)
1989
32
Human pulmonary dirofilariasis: does diagnosis require thoracotomy? (3355289)
1988
33
Human pulmonary dirofilariasis. (3384627)
1988
34
Clinical effects after heartworm removal from pulmonary arteries using flexible alligator forceps in dogs with common dirofilariasis. (3210484)
1988
35
Lipids in serum, lipoproteins and erythrocyte membranes in canine dirofilariasis by TLC-FID method. (3586455)
1987
36
Dirofilariasis presenting as a breast lump (correction) (6498666)
1984
37
Dirofilariasis with arteriosclerosis in a horse. (6480468)
1984
38
Dirofilariasis in a ferret. (7085481)
1982
39
Human subcutaneous dirofilariasis. 1. Two new cases in Venice. Identification of the causal agent as Dirofilaria repens Raillet and Henry, 1911. (6926932)
1982
40
Serum total bile acid levels in canine dirofilariasis. (7182632)
1982
41
Dirofilariasis of the breast in france. (7435780)
1980
42
Human subcutaneous dirofilariasis in Illinois. (660850)
1978
43
Electrophoretical studies on serum lipoprotein fractions in canine dirofilariasis. (916460)
1977
44
Experimental dirofilariasis in macaques. III. Susceptibility and host responses to Dirofilaria tenuis of raccoons. (816216)
1976
45
Letter: Human pulmonary dirofilariasis: entry method of infective larvae. (238798)
1975
46
Experimental occult dirofilariasis in dogs with reference to immunological responses and its relationship to tropical eosinophilia in man. (4617308)
1974
47
Ruptured pulmonary artery in a dog with dirofilariasis. (4721753)
1973
48
Human pulmonary dirofilariasis. (5110572)
1971
49
Feline dirofilariasis in Papula. (6007745)
1966
50
Canine dirofilariasis. II. Utilization of a rapid film change technique. (14398841)
1960

Variations for Dirofilariasis

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Expression for genes affiliated with Dirofilariasis

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Search GEO for disease gene expression data for Dirofilariasis.

Pathways for genes affiliated with Dirofilariasis

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Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ALDOA, ALDOB
2
Show member pathways
9.1ALDOA, ALDOB
3
Show member pathways
9.1ALDOA, ALDOB
4
Show member pathways
8.5ALDOA, ALDOB, TKT
5
Show member pathways
8.5ALDOA, ALDOB, TKT
6
Show member pathways
8.5ALDOA, ALDOB, TKT
7
Show member pathways
7.5ALDOA, ALDOB, AMD1, MT-CO1, TKT

GO Terms for genes affiliated with Dirofilariasis

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Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1response to copper ionGO:00466889.8ALDOB, MT-CO1
2fructose metabolic processGO:00060009.7ALDOA, ALDOB
3glycolytic processGO:00060969.7ALDOA, ALDOB
4fructose 1,6-bisphosphate metabolic processGO:00303889.7ALDOA, ALDOB
5canonical glycolysisGO:00616219.7ALDOA, ALDOB
6gluconeogenesisGO:00060949.6ALDOA, ALDOB
7glucose metabolic processGO:00060069.5ALDOA, ALDOB
8carbohydrate metabolic processGO:00059758.7ALDOA, ALDOB, TKT
9small molecule metabolic processGO:00442817.5ALDOA, ALDOB, AMD1, MT-CO1, TKT

Molecular functions related to Dirofilariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fructose-bisphosphate aldolase activityGO:00043329.4ALDOA, ALDOB
2fructose bindingGO:00700619.3ALDOA, ALDOB
3cytoskeletal protein bindingGO:00080929.1ALDOA, ALDOB

Sources for Dirofilariasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet