MCID: DRF001
MIFTS: 40

Dirofilariasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Dirofilariasis

MalaCards integrated aliases for Dirofilariasis:

Name: Dirofilariasis 12 49 55 3 41 14 69
Dirofilaria Infectious Disease 12
Infection by Dirofilaria 12

Characteristics:

Orphanet epidemiological data:

55
dirofilariasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1082
ICD10 32 B74.8
MeSH 41 D004184
SNOMED-CT 64 73328005
Orphanet 55 ORPHA166291
MESH via Orphanet 42 D004184
UMLS via Orphanet 70 C0012602
ICD10 via Orphanet 33 B74.8
UMLS 69 C0012602

Summaries for Dirofilariasis

NIH Rare Diseases : 49 Dirofilariasis refers to infections caused by Dirofilaria roundworms. Although the natural hosts of these roundworms are dogs, wild canids (such as wolves and foxes) and raccoons, humans can be infected with Dirofilaria larvae through mosquito bites. Signs and symptoms of dirofilariasis generally include nodules under the skin or lung granulomas (small nodules formed by an inflammatory reaction) which may be asymptomatic. Some people with dirofilariasis of the lungs may also experience cough, chest pain, fever, wheezing, chills, and pleural effusion (excess fluid between the tissues that line the lungs and the chest cavity). Dirofilariasis is treated with surgical removal of lung granulomas and skin nodules. Last updated: 4/27/2016

MalaCards based summary : Dirofilariasis, also known as dirofilaria infectious disease, is related to louping ill and cryofibrinogenemia. An important gene associated with Dirofilariasis is UBASH3A (Ubiquitin Associated And SH3 Domain Containing A), and among its related pathways/superpathways are amb2 Integrin signaling and Dissolution of Fibrin Clot. Affiliated tissues include lung, skin and testes, and related phenotypes are cardiovascular system and muscle

CDC : 3 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

Disease Ontology : 12 A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

Wikipedia : 72 Dirofilariasis is an infection by parasites in the Dirofilaria... more...

Related Diseases for Dirofilariasis

Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 louping ill 10.5 CD40LG STAB2
2 cryofibrinogenemia 10.5 CD40LG HP
3 sparganosis 10.5 CTSL MT-CO1
4 west nile fever 10.5 CD40LG STAB2
5 fasciolopsiasis 10.4 CD40LG CTSL
6 fiedler's myocarditis 10.4 CTSL CUX1
7 geniculate herpes zoster 10.4 CD40LG HP
8 glandular tularemia 10.4 CRP STAB2
9 cerebral arteritis 10.4 CD40LG PLG
10 neuronitis 10.4 CD40LG MB
11 parasitic protozoa infectious disease 10.4 CD40LG HP MT-CO1
12 acquired angioedema 10.3 CRP HP
13 taeniasis 10.3 CD40LG CTSL MT-CO1
14 parasitic helminthiasis infectious disease 10.3 CD40LG CTSL MT-CO1
15 intracranial vasospasm 10.3 HP PLAT
16 evans' syndrome 10.3 CD40LG HP
17 chronic meningitis 10.3 CRP MT-CO1
18 ulceroglandular tularemia 10.3 CRP STAB2
19 acalculous cholecystitis 10.3 CD40LG CRP
20 mononeuritis multiplex 10.3 CD40LG CRP
21 erysipeloid 10.3 GAPDH PLG UBASH3A
22 sleeping sickness 10.3 AMD1 GAPDH HP
23 ligneous conjunctivitis 10.2 PLAT PLG
24 middle cerebral artery infarction 10.2 CD40LG PLAT
25 melancholia 10.2 CRP HP
26 acute maxillary sinusitis 10.2 CD40LG CRP
27 inferior myocardial infarction 10.2 PLAT PLG
28 blue toe syndrome 10.2 CRP PLG
29 takayasu arteritis 10.1 CD40LG CRP PON1
30 central retinal artery occlusion 10.1 PLAT PLG
31 murray valley encephalitis 10.1 CD40LG STAB2
32 intracranial embolism 10.1 PLAT PLG
33 coronary stenosis 10.1 CRP PON1 TNNI3
34 japanese spotted fever 10.1 CD40LG CRP
35 myocarditis 10.1 CD40LG MB TNNI3
36 cardiogenic shock 10.1 CRP PLAT
37 dressler's syndrome 10.0 CD40LG CRP PLAT
38 disseminated intravascular coagulation 10.0 MB PLAT PLG
39 deficiency anemia 9.9 CRP HP PON1
40 pulmonary embolism 9.9 CRP PLAT TNNI3
41 lung cancer 9.9
42 langerhans cell histiocytosis 9.9
43 hepatitis 9.9
44 filariasis 9.9
45 histiocytosis 9.9
46 meningitis 9.9
47 posterior myocardial infarction 9.8 MB PLAT TPT1
48 carotid artery dissection 9.8 PLAT PLG RET
49 ischemia 9.8 CTSL MB PLAT PON1
50 hypertension, essential 9.8 CRP HP PLAT PON1

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to Dirofilariasis

Symptoms & Phenotypes for Dirofilariasis

MGI Mouse Phenotypes related to Dirofilariasis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CD40LG CRP HP MB MT-CO1 NSUN2
2 muscle MP:0005369 9.5 TNNI3 MB MT-CO1 NSUN2 PLAT RET
3 respiratory system MP:0005388 9.17 MB NSUN2 PLAT PLG RET STAB2

Drugs & Therapeutics for Dirofilariasis

Search Clinical Trials , NIH Clinical Center for Dirofilariasis

Cochrane evidence based reviews: dirofilariasis

Genetic Tests for Dirofilariasis

Anatomical Context for Dirofilariasis

MalaCards organs/tissues related to Dirofilariasis:

38
Lung, Skin, Testes, B Cells, Heart, Eye

Publications for Dirofilariasis

Articles related to Dirofilariasis:

(show top 50) (show all 416)
# Title Authors Year
1
Dirofilariasis mimicking an osteoma. ( 29323001 )
2018
2
Conjunctival Dirofilariasis Causing Symptoms for 1 Day. ( 29351119 )
2018
3
The Canary Islands as a model of risk of pulmonary dirofilariasis in a hyperendemic area. ( 29396676 )
2018
4
Clinical and laboratory features of human dirofilariasis in Russia. ( 28791217 )
2017
5
Ocular Dirofilariasis: A Rare case from Mumbai, India. ( 28764165 )
2017
6
A case of orbital dirofilariasis in New York. ( 28812912 )
2017
7
Intradural Dirofilariasis in a Dog with Chronic Cervical Pain. ( 27841685 )
2017
8
Subcutaneous dirofilariasis caused by Dirofilaria (Nochtiella) repens in Sri Lanka: A potential risk of transmitting human dirofilariasis. ( 28491315 )
2017
9
Delayed diagnosis of subcutaneous dirofilariasis following a mosquito bite sustained in Germany. ( 28557282 )
2017
10
Dirofilariasis in a Female Adult Patient in Israel. ( 28971644 )
2017
11
Human Subconjunctival Dirofilariasis Presenting as the Daytime Photophobia: A Case Report. ( 29308388 )
2017
12
Ocular dirofilariasis by Dirofilaria immitis in a child in Iran: A case report and review of the literature. ( 27815230 )
2017
13
An unusual presentation of lacrimal gland dirofilariasis. ( 28724822 )
2017
14
Ocular dirofilariasis: Ophthalmic implication of climate change on vector-borne parasites. ( 29260070 )
2017
15
A case of human ocular dirofilariasis in a patient with multiple endocrine neoplasia in Northwest Spain. ( 29223316 )
2017
16
Periocular dirofilariasis: A case series. ( 26819190 )
2016
17
Subcutaneous filariasis in India- Possible indication of human Dirofilariasis. ( 27004586 )
2016
18
Human Ocular Dirofilariasis in Hong Kong. ( 26636400 )
2016
19
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. ( 28000235 )
2016
20
Subcutaneous and Pulmonary Dirofilariasis with Evidence of Splenic Involvement. ( 27579206 )
2016
21
A rare case of human pulmonary dirofilariasis with a growing pulmonary nodule after migrating infiltration shadows, mimicking primary lung carcinoma. ( 27015012 )
2016
22
Rare case of epididymal dirofilariasis. ( 26976948 )
2016
23
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space. ( 27305941 )
2016
24
Human pulmonary dirofilariasis masquerading as a mass. ( 27432058 )
2016
25
Periorbital Dirofilariasis: A Rare Case from Western India. ( 27134918 )
2016
26
Human dirofilariasis in the eyelid caused by Dirofilaria repens: An imported case. ( 27544021 )
2016
27
Ocular dirofilariasis: Series of three cases and review of literature. ( 27080800 )
2016
28
Dirofilariasis involving the oral cavity: report of the first case from South America. ( 26108021 )
2015
29
Dirofilariasis - an emergent human parasitosis in Romania. ( 26204187 )
2015
30
Dirofilariasis Mimicking an Acute Scrotum. ( 25626639 )
2015
31
Dirofilariasis of the breast: Two new cases in Tunisia. ( 26446746 )
2015
32
18-FDG Uptake in Pulmonary Dirofilariasis. ( 26622926 )
2015
33
Human dirofilariasis: an emerging zoonosis in India. ( 26064035 )
2015
34
Cutaneous and pulmonary dirofilariasis due to Dirofilaria repens. ( 25918821 )
2015
35
Human subcutaneous/ocular dirofilariasis in the Russian Federation and Belarus, 1997-2013. ( 25722281 )
2015
36
Assessing the Susceptibility Status of Mosquitoes (Diptera: Culicidae) in a Dirofilariasis Focus, Northwestern Iran. ( 26114140 )
2015
37
Human subcutaneous dirofilariasis caused by Dirofilaria immitis in a Greek adult. ( 26166816 )
2015
38
A rare case of anterior chamber dirofilariasis. ( 25709276 )
2015
39
A Case Report on Oral Subcutaneous Dirofilariasis. ( 26858848 )
2015
40
Dirofilariasis by Dirofilaria repens: an imported case and a brief review. ( 25769814 )
2015
41
Human ocular dirofilariasis due to Dirofilaria repens in Sri Lanka. ( 26706673 )
2015
42
Subcutaneous Infraorbital Dirofilariasis. ( 26288429 )
2015
43
Human dirofilariasis: A fast emerging zoonosis in India. ( 26470975 )
2015
44
Pulmonary dirofilariasis: A diagnostic pitfall in clinical practice. ( 26526293 )
2015
45
First detection of human dirofilariasis in South Africa. ( 25874068 )
2015
46
Subcutaneous dirofilariasis of the eyelid in a 7-month-old infant. ( 25871532 )
2015
47
Risk factors for human heartworm infections (dirofilariasis) in the South. ( 25978057 )
2015
48
Subcutaneous human Dirofilariasis in Vidarbha. ( 26275274 )
2015
49
Subconjunctival dirofilariasis caused by Dirofilaria repens: A case report with short review. ( 26275256 )
2015
50
Human subcutaneous dirofilariasis of forearm an unusual presentation. ( 25657423 )
2015

Variations for Dirofilariasis

Expression for Dirofilariasis

Search GEO for disease gene expression data for Dirofilariasis.

Pathways for Dirofilariasis

Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.48 HP PLAT PLG
2 10.27 PLAT PLG
3 9.86 MB MT-CO1

GO Terms for Dirofilariasis

Cellular components related to Dirofilariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CD40LG CRP CTSL HP PLAT PLG
2 extracellular exosome GO:0070062 9.36 CRP CTSL GAPDH HP MB PLAT

Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 8.62 PLAT PLG

Molecular functions related to Dirofilariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 low-density lipoprotein particle binding GO:0030169 8.96 CRP STAB2
2 serine-type endopeptidase activity GO:0004252 8.92 CTSL HP PLAT PLG

Sources for Dirofilariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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