MCID: DRF001
MIFTS: 34

Dirofilariasis malady

Infectious diseases category

Summaries for Dirofilariasis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Dirofilariasis in humans is caused by Dirofilaria roundworms. The main natural hosts for the three Dirofilaria species that most frequently cause disease in humans are dogs and wild canids (such as wolves and foxes) and raccoons. Humans are infected with Dirofilaria larvae through mosquito bites. Infection can result in nodules under the skin or conjunctiva and lung granulomas (small nodules formed by an inflammatory reaction) that appear as coin lesions (small, round abnormalities) on x-rays, leading to diagnostic procedures to exclude more serious diseases.

MalaCards: Dirofilariasis, also known as dirofilaria infectious disease, is related to pulmonary coin lesion and eosinophilia. An important gene associated with Dirofilariasis is NSUN2 (NOP2/Sun RNA methyltransferase family, member 2). Affiliated tissues include lung, skin and breast, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A filariasis that is a zoonotic infection caused by nematodes dirofilaria immitis or dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. the disease manifests as either subcutaneous nodules or pulmonary lesions.

Wikipedia:63 Dirofilariasis is an infection by parasites in the Dirofilaria genus. more...

Aliases & Classifications for Dirofilariasis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
dirofilariasis:
Prevalence: <1/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

dirofilariasis 8 42 10 48 60
dirofilaria infectious disease 8
infection by dirofilaria 8


External Ids:

Disease Ontology8 DOID:1082
MeSH34 D004184
MESH via Orphanet35 D004184
SNOMED-CT56 73328005
ICD10 via Orphanet26 B74.8
SNOMED-CT via Orphanet57 73328005
UMLS via Orphanet61 C0012602

Related Diseases for Dirofilariasis

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17GeneCards, 18GeneDecks
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Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 27)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary coin lesion10.2
2eosinophilia10.1
3hepatitis10.1
4histiocytosis10.1
5langerhans-cell histiocytosis10.1
6lung cancer10.1
7meningitis10.1
8onchocerciasis9.9
9reactive arthritis9.9
10eosinophilic meningitis9.9
11fascioliasis9.9
12toxocariasis9.9
13arteriosclerosis9.9
14arthritis9.9
15breast cancer9.9
16congestive heart failure9.9
17filariasis9.9
18hypertension9.9
19lung benign neoplasm9.9
20mediastinitis9.9
21neurilemmoma9.9
22orbital cancer9.9
23osteosarcoma9.9
24pneumothorax9.9
25proteinuria9.9
26scleritis9.9
27transitional cell carcinoma9.9

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to dirofilariasis

Clinical Features for Dirofilariasis

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Drugs & Therapeutics for Dirofilariasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dirofilariasis

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Anatomical Context for Dirofilariasis

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32MalaCards
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MalaCards organs/tissues related to Dirofilariasis:

32
Lung, Skin, Breast, Testes, Eye, Heart, B cells

Animal Models for Dirofilariasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dirofilariasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.1UBASH3A, NSUN2

Publications for Dirofilariasis

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50PubMed
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Articles related to Dirofilariasis:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
Periocular dirofilariasis mimicking lacrimal sac mucocoele. (23895409)
2013
2
Periorbital dirofilariasis-clinical and imaging findings: live worm on ultrasound. (23803483)
2013
3
Intramuscular dirofilariasis mimicking an orbital metastasis in a patient with breast cancer. (23008795)
2012
4
Subconjunctival dirofilariasis mimicking scleritis: first report from Western India. (22218259)
2012
5
Orbital dirofilariasis in Iran: a case report. (19967089)
2009
6
Zoonotic filariasis in the Arabian Peninsula: autochthonous onchocerciasis and dirofilariasis. (18981515)
2008
7
A case of human pulmonary dirofilariasis. (18547856)
2008
8
Subcutaneous dirofilariasis caused by Dirofilaria immitis mimicking a large epidermal cyst. (16643162)
2006
9
Human pulmonary dirofilariasis: atypical presentation of a rare disease. (16501778)
2006
10
PET findings in pulmonary dirofilariasis. (16282912)
2005
11
Subcutaneous dirofilariasis in southern India: a case report. (15949193)
2005
12
Subcutaneous dirofilariasis caused by Dirofilaria repens. (15573204)
2004
13
Human dirofilariasis in Costa Rica: Dirofilaria immitis in periorbital tissues. (12669355)
2003
14
Canine dirofilariasis in the region of ConceiAsALo Lagoon, FlorianA^polis, and in the Military Police kennel, SALo JosAc, State of Santa Catarina, Brazil. (12719138)
2003
15
Subconjunctival dirofilariasis in India. (11556571)
2001
16
Pulmonary dirofilariasis in a patient with multisystem Langerhans cell histiocytosis--the first reported case in Thailand. (9737133)
1998
17
Utility of antibodies against a 22 kD molecule of Dirofilaria immitis in the diagnosis of human pulmonary dirofilariasis. (9537278)
1998
18
Ophthalmic dirofilariasis. (9152076)
1997
19
Dirofilariasis with conjunctival inflammation. (9236762)
1997
20
Human pulmonary dirofilariasis. (8818697)
1996
21
Intrahepatic portal-venous changes in dogs with dirofilariasis: scanning electron microscopy of resin casts of vasculature. (7492667)
1995
22
Survey of dirofilariasis in Arkansas. (8350083)
1993
23
Pulmonary dirofilariasis cytologically mimicking lung cancer. A case report. (8328248)
1993
24
Human pulmonary dirofilariasis: report of a new European case. (2134386)
1990
25
Pulmonary dirofilariasis: restudy of worms reported gravid. (2389822)
1990
26
Human pulmonary dirofilariasis. (3384627)
1988
27
Human pulmonary dirofilariasis. Report of three cases and brief review of the literature. (4014074)
1985
28
Pulmonary dirofilariasis diagnosed by computerised tomography scan controlled percutaneous needle aspiration. (3867345)
1985
29
Pulmonary dirofilariasis in a Costa Rican man. (3834799)
1985
30
Regional hypoxic pulmonary vasoconstriction in dogs with asymptomatic dirofilariasis. (4026011)
1985
31
Dirofilariasis presenting as a breast lump (correction) (6498666)
1984
32
Aberrant dirofilariasis in a cat. (6698854)
1984
33
Human pulmonary dirofilariasis. (6591027)
1984
34
Detection of circulating parasite antigens in canine dirofilariasis by counterimmunoelectrophoresis. (6731674)
1984
35
Angles of branching and the diameters of pulmonary arteries in relation to the distribution of pulmonary lesions in canine dirofilariasis. (6665319)
1983
36
Urinalysis in canine dirofilariasis with emphasis on proteinuria. (6845596)
1983
37
Lesions in pulmonary artery in feline dirofilariasis. (7098237)
1982
38
Ocular dirofilariasis in the dog. (7464799)
1981
39
Human pulmonary dirofilariasis in the West. (7222665)
1981
40
Subcutaneous dirofilariasis of the eyelid and ocular adnexa. Report of six cases. (7387513)
1980
41
Subcutaneous dirofilariasis in Illinois. (563974)
1978
42
Dirofilariasis in a 2-year-old Husky-Shepherd cross in Maine. (243310)
1977
43
Pulmonary dirofilariasis: another coin lesion. (850826)
1977
44
Letter: Human pulmonary dirofilariasis: entry method of infective larvae. (238798)
1975
45
Human pulmonary dirofilariasis. (4858679)
1974
46
Dirofilariasis: radiologic diagnosis. (4701163)
1973
47
Human pulmonary dirofilariasis. (5062180)
1972
48
Dirofilariasis in Canada. (5104358)
1971
49
Feline dirofilariasis in Papula. (6007745)
1966
50
A case of dirofilariasis involving the lung. (13719853)
1961

Genetic Variations for Dirofilariasis

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Expression for genes affiliated with Dirofilariasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dirofilariasis

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Pathways for genes affiliated with Dirofilariasis

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Compounds for genes affiliated with Dirofilariasis

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GO Terms for genes affiliated with Dirofilariasis

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Products for genes affiliated with Dirofilariasis

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Sources for Dirofilariasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet