Disordered Steroidogenesis malady

MalaCards: Disordered Steroidogenesis is related to antley-bixler syndrome and synostosis. An important gene associated with Disordered Steroidogenesis is POR (P450 (cytochrome) oxidoreductase). The compounds nadph and erythromycin have been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and behavior/neurological.

disordered steroidogenesis 7

Diseases related to disordered steroidogenesis by text searches and GeneDecks gene sharing:

(show all 32)

id	Related Disease	Score	Top Affiliating Genes
1	antley-bixler syndrome	27.2	POR, CYP17A1, CYCS, FGFR2
2	synostosis	12.8	FGFR2, POR
3	17-alpha-hydroxylase/17,20-lyase deficiency	12.7	POR, CYP17A1
4	21-hydroxylase deficiency	12.7	POR, CYP17A1
5	gynecomastia	12.7	CYP17A1, POR
6	craniosynostosis	12.7	FGFR2, POR
7	adrenal adenoma	12.7	CYP17A1, POR
8	virilization	12.7	POR, CYP17A1
9	hypospadias	12.6	FGFR2, CYP17A1
10	addison's disease	12.6	POR, CYP17A1
11	adrenal hyperplasia	12.6	CYP17A1, POR
12	cushing's syndrome	12.4	CYP17A1, POR
13	hereditary breast ovarian cancer	12.3	FGFR2, CYP17A1
14	breast cancer	12.3	FGFR2, CYP17A1
15	acne	12.2	FGFR2, CYP17A1
16	chst3-related skeletal dysplasia	12.2	FGFR2, CYP17A1, POR
17	breast cancer susceptibility	12.0	FGFR2, CYP17A1
18	pandas	11.9	CYCS, CYP17A1, POR
19	endometrial carcinoma	11.8	CYP17A1, CYCS, FGFR2
20	epithelial ovarian cancer	11.8	FGFR2, CYCS, CYP17A1
21	prostate carcinoma	11.8	CYP17A1, CYCS, FGFR2
22	colon carcinoma	11.8	POR, CYCS, FGFR2
23	breast carcinoma	11.4	POR, CYP17A1, CYCS, FGFR2
24	pancreatic cancer	11.3	POR, CYP17A1, CYCS, FGFR2
25	colon cancer	11.3	POR, CYP17A1, CYCS, FGFR2
26	ovarian cancer	11.3	FGFR2, CYCS, CYP17A1, POR
27	pancreatitis	11.2	FGFR2, CYCS, CYP17A1, POR
28	lung carcinoma	11.1	POR, CYP17A1, CYCS, FGFR2
29	antley-bixler syndrome-like with disordered steroidogenesis	6.8
30	antley-bixler syndrome with genital anomalies and disordered steroidogenesis	6.8
31	disordered steroidogenesis due to cytochrome p450 oxidoreductase	6.8
32	por deficiency	6.8

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to disordered steroidogenesis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	8.6	FGFR2, CYCS, POR
2	behavior/neurological phenotype	MP:0005386	7.7	FGFR2, CYCS, CYP17A1, POR

Articles related to disordered steroidogenesis:

id	Title	Authors	Year	Affiliating Genes
1	Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. (15793702)	Huang N.... Miller W.L.	2005	FGFR2, POR, CYP17A1
2	P450 oxidoreductase deficiency: a new disorder of steroidogenesis. (16467261)	Miller W.L.... Agrawal V.	2005	FGFR2, POR, CYP17A1
3	Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. (14758361)	Flueck C.E.... Miller W.L.	2004	POR
4	P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes. (15666840)	Pandey A.V.... Miller W.L.	2004	POR
5	P450 oxidoreductase deficiency: a new disorder of steroidogenesis with multiple clinical manifestations. (15350602)	Miller W.L.	2004	POR

Genes related to disordered steroidogenesis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	POR	P450 (cytochrome) oxidoreductase	11.1	Publications, Summaries
2	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0	Publications
3	CYCS	cytochrome c, somatic	11.0	Publications
4	FGFR2	fibroblast growth factor receptor 2	11.0	Publications

Compounds related to disordered steroidogenesis according to GeneDecks:

(show all 43)

id	Compound	Score	Top Affiliating Genes
1	nadph32 18	11.0	CYCS
2	erythromycin32 9 9	11.8	POR, FGFR2
3	17-hydroxypregnenolone32	9.8	CYP17A1, POR
4	aminopyrine32	9.8	POR, CYP17A1
5	17-hydroxyprogesterone32 18	10.7	POR, CYP17A1
6	androstane32	9.7	POR, CYP17A1
7	diethylstilbestrol32 9 9	11.7	POR, CYP17A1
8	3beta-hydroxysteroid32	9.7	CYP17A1, POR
9	dhea32	9.6	POR, CYP17A1
10	androstenedione32 18	10.6	POR, CYP17A1
11	2,6-dichlorophenolindophenol32	9.6	CYCS, POR
12	ferricyanide32	9.6	CYCS, POR
13	hydroquinone32 18	10.5	POR, CYCS
14	haem32	9.5	POR, CYCS
15	tetrahydrobiopterin32 9 18 9	12.5	CYCS, POR
16	flavin32	9.5	POR, CYCS
17	estrone32 9 18 9	12.5	CYP17A1, POR
18	diphenyleneiodonium32	9.5	CYCS, POR
19	xanthine32 18	10.5	CYCS, POR
20	menadione32 9 18 9	12.5	CYCS, POR
21	guanidine hydrochloride32	9.4	POR, CYCS
22	nifedipine32 9 9	11.4	CYP17A1, POR
23	4-hydroxynonenal32 18	10.4	POR, CYCS
24	15-deoxy-delta-12,14-prostaglandin j232	9.3	CYCS, CYP17A1
25	dihydrotestosterone32 9 18 9	12.3	CYP17A1, POR
26	alpha tocopherol32	9.3	CYCS, POR
27	resveratrol32 9 18 9	12.2	POR, CYCS
28	vitamin d32	9.2	POR, CYP17A1, FGFR2
29	testosterone32 9 18 9	12.1	FGFR2, CYP17A1, POR
30	steroid32	9.0	FGFR2, CYP17A1, POR
31	arginine32	9.0	POR, CYP17A1, FGFR2
32	doxorubicin32 34 9 9	12.0	FGFR2, CYCS, POR
33	cisplatin32 34 9 9	12.0	FGFR2, CYCS, POR
34	Heme9 18 9	10.9	CYCS, CYP17A1, POR
35	oxygen32 18	9.9	CYCS, CYP17A1, POR
36	nadh32 9 18 9	11.9	CYCS, CYP17A1, POR
37	h2o232	8.9	FGFR2, CYCS, POR
38	pd 98,05932	8.9	FGFR2, CYCS, CYP17A1
39	quercetin32 42 9 18 9	12.8	CYCS, POR
40	estrogen32	8.7	POR, CYP17A1, FGFR2
41	retinoic acid32 42 18	10.5	FGFR2, CYCS, CYP17A1
42	cysteine32	8.4	POR, CYP17A1, CYCS, FGFR2
43	serine32	8.4	FGFR2, CYCS, CYP17A1, POR

Biological processes related to disordered steroidogenesis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of steroid hormone biosynthetic process	GO:090031	9.3	CYP17A1, POR

Molecular functions related to disordered steroidogenesis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	electron carrier activity	GO:009055	9.3	CYP17A1, POR
2	heme binding	GO:020037	8.7	CYCS, CYP17A1
3	iron ion binding	GO:005506	8.4	CYCS, CYP17A1, POR