DIC
MCID: DSS009
MIFTS: 66

Disseminated Intravascular Coagulation (DIC) malady

Immune diseases, Blood diseases categories

Summaries for Disseminated Intravascular Coagulation

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63Wikipedia, 32MalaCards
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Wikipedia:63 Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or... more...

MalaCards: Disseminated Intravascular Coagulation, also known as dissemin. intravascular coag., is related to leukemia and acute leukemia. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and Selected targets of C/EBPalpha. The drugs antithrombin iii, human and antithrombin iii,recombinant and the compounds ancrod and epsilon aminocaproic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Disseminated Intravascular Coagulation

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

disseminated intravascular coagulation 8 10 44 60
dissemin. intravascular coag. 8
defibrination syndrome 8
diffuse 8
dic 8


External Ids:

Disease Ontology8 DOID:11247
ICD9CM27 286.6
MeSH34 D004211
SNOMED-CT56 67406007, 267563002
NCIt39 C2992
ICD1025 D65

Related Diseases for Disseminated Intravascular Coagulation

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17GeneCards, 18GeneDecks
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Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1580)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.3SERPINF2, THPO, FGA, PF4, PPBP, F9
2acute leukemia31.3THPO, FGA
3purpura31.2ADAMTS13, SERPINC1, THPO
4liver cirrhosis30.9ADAMTS13, SERPINF2, SERPINC1, THPO, F2, F3
5hepatitis30.9THPO, F2, TAT
6thrombocytopenia30.9ADAMTS13, SERPINC1, THPO, THBD, F2, F3
7glomerulonephritis30.9ELANE
8pancreatitis30.8ELANE
9peritonitis30.8F2
10pneumonia30.8ELANE, FGA
11protein s deficiency30.8SERPINC1, F5, F9
12pulmonary embolism30.8SERPINF2, SERPINC1, F2, F3, FGA, PF4
13acute pancreatitis30.7ELANE
14malaria30.7ADAMTS13, TSPAN32, TAT
15lupus erythematosus30.7SERPINC1, THBD, F2, F3, F5
16adenocarcinoma30.7TSPAN32, THBD, TAT, PF4, TNXA
17hemolytic-uremic syndrome30.6ADAMTS13, THBD
18hellp syndrome30.6ADAMTS13, SERPINC1, SERPINE1, F5
19placental abruption30.6SERPINC1, F5
20protein c deficiency30.6SERPINC1, SERPINE1, THBD, F2, PROC, F5
21antiphospholipid syndrome30.6ADAMTS13, SERPINC1, THBD, F2, F3, PF4
22systemic lupus erythematosus30.6ADAMTS13, THBD, F2, F3, FGA
23myocardial infarction30.6ADAMTS13, SERPINF2, SERPINC1, SERPINE1, F3, TAT
24systemic scleroderma30.5THBD, FGA, PF4, PPBP
25hepatitis a30.5F2
26coronary thrombosis30.5SERPINC1, SERPINE1, F3
27purpura fulminans30.5SERPINC1, PROC, F5
28antithrombin iii deficiency30.5SERPINC1, F2, F5
29amyloidosis30.5F9
30ischemia30.5ADAMTS13, TAT, FGA, PF4
31factor x deficiency30.5F2, F3, F5, F9
32hypertension30.5SERPINE1, F2, F5, PPBP
33diabetes mellitus30.5SERPINC1, SERPINE1, THBD, FGA, PF4
34adult respiratory distress syndrome30.5ELANE, THBD, F5
35acute myocardial infarction30.5ADAMTS13, SERPINF2, SERPINC1, SERPINE1, THBD, F3
36breast cancer30.5TSPAN32, SERPINE1, THPO, PPBP, CAMP, F9
37arthritis30.4TAT
38rheumatoid arthritis30.4ELANE, TSPAN32, THPO, PF4, PPBP
39sarcoma30.3THPO, TAT
40herpes simplex30.3TAT, CAMP, F9
41dementia30.3TAT
42hepatitis b30.2F2, TAT, F9
43polycythemia30.2THPO, PPBP
44schistosomiasis30.2TSPAN32, SERPINF2, PPBP
45polycythemia vera30.2THPO, THBD, PF4
46acquired immunodeficiency syndrome30.2TAT
47factor v deficiency30.2F2, F3, F5
48myeloma30.2TSPAN32, PF4
49portal vein thrombosis30.2SERPINC1, THPO, F2, F5
50vitamin k deficiency hemorrhagic disease30.2F2, F3

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to disseminated intravascular coagulation

Clinical Features for Disseminated Intravascular Coagulation

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Drugs & Therapeutics for Disseminated Intravascular Coagulation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Disseminated Intravascular Coagulation

Drug clinical trials:

Search ClinicalTrials for Disseminated Intravascular Coagulation

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Search CenterWatch for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Disseminated Intravascular Coagulation

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Anatomical Context for Disseminated Intravascular Coagulation

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32MalaCards
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MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

32
Kidney, Skin, Liver, Prostate, Testes, Bone, Bone marrow, Endothelial, Brain, Heart, T cells, Thyroid, Lung, Monocytes, Colon, B cells, Breast, Spleen, Myeloid, Tongue, Placenta, Whole blood

Animal Models for Disseminated Intravascular Coagulation or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.4F3, FGA, F2, F9
2MP:000539710.2F3, PROC, F9, FGA, ELANE, ADAMTS13
3MP:000538710.2THBD, F2, FGA, PROC, CAMP, F9
4MP:000537610.1F3, FGA, PF4, PROC, F2, THBD
5MP:001076810.0SERPINE1, CAMP, ELANE, ADAMTS13, SERPINC1, THBD
6MP:000537010.0F5, THBD, FGA, PROC, SERPINE1, SERPINC1

Publications for Disseminated Intravascular Coagulation

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50PubMed
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Articles related to Disseminated Intravascular Coagulation:

(show top 50)    (show all 743)
idTitleAuthorsYear
1
Poor prognosis of hypocoagulability assessed by thrombin generation assay in disseminated intravascular coagulation. (24418939)
2014
2
Coagulofibrinolytic changes in patients with disseminated intravascular coagulation associated with post-cardiac arrest syndrome--fibrinolytic shutdown and insufficient activation of fibrinolysis lead to organ dysfunction. (23726093)
2013
3
Disseminated intravascular coagulation in heat stroke: a hot topic. (22425849)
2012
4
High mobility group B1 levels in sepsis and Disseminated Intravascular Coagulation. (23094260)
2012
5
Disseminated Intravascular Coagulation, Hemoperitoneum, and Reversible Ischemic Neurological Deficit Complicating Anaphylaxis to Prophylactic Antibiotics during Cesarean Delivery: A Case Report and Review of Literature. (23705078)
2011
6
Hepatocyte Growth Factor: a marker and a player in disseminated intravascular coagulation. (20307902)
2011
7
Tissue factor as a target for the treatment of disseminated intravascular coagulation. (21531009)
2011
8
Disseminated intravascular coagulation: a disease-specific approach. (20614388)
2010
9
Hyperacute disseminated intravascular coagulation following surgery for a choroid plexus carcinoma in a child. (20644287)
2010
10
Neonatal disseminated intravascular coagulation after thrombosis of a fetal intra-abdominal umbilical vein varix. (20373943)
2010
11
Acute kidney injury due to menstruation-related disseminated intravascular coagulation in an adenomyosis patient: a case report. (20808684)
2010
12
Laboratory testing in disseminated intravascular coagulation. (20614398)
2010
13
Purpura fulminans: a cutaneous marker of disseminated intravascular coagulation. (19561767)
2009
14
Effects of antithrombin III in patients with disseminated intravascular coagulation diagnosed by newly developed diagnostic criteria for critical illness. (18840625)
2009
15
Disseminated intravascular coagulation in cancer patients. (19285279)
2009
16
Effective therapy with tranexamic acid in a case of chronic disseminated intravascular coagulation with acquired alpha2-antiplasmin deficiency associated with AL amyloidosis. (19967165)
2009
17
The critical analysis on diagnosis of disseminated intravascular coagulation with screening tests--a scoring system and related literature review. (18693613)
2007
18
Place of antithrombin III concentrate in the intensive care of disseminated intravascular coagulation]. (17563999)
2007
19
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. (17059423)
2007
20
Patient with disseminated intravascular coagulation as the first manifestation of adenocarcinoma of the prostate. Risks of prostatic biopsy. (16331297)
2006
21
A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis. (16988545)
2006
22
Disseminated intravascular coagulation after laparoscopic multiple myomectomy with use of icodextrin: a case report. (16962537)
2006
23
The Leiden mutation and activated protein C resistance as risk factors for disseminated intravascular coagulation in acutely poisoned patients. (16496494)
2006
24
Disseminated intravascular coagulation unmasked by Mohs micrographic surgery. (16706778)
2006
25
Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. (16189276)
2006
26
Back to the future: testing in disseminated intravascular coagulation. (16269925)
2005
27
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. (15878975)
2005
28
Mycobacterium tuberculosis inducing disseminated intravascular coagulation. (15841321)
2005
29
Disseminated intravascular coagulation (DIC) in a kidney donor associated with transient recipient DIC. (15644003)
2005
30
Relationship between endothelin and the pathophysiology of tissue factor-induced and lipopolysaccharide-induced disseminated intravascular coagulation in rats: a study examining the effect of an endothelin receptor antagonist. (15389127)
2004
31
Antithrombin III assay using thrombin in disseminated intravascular coagulation (DIC), other thromboembolic disorders and hepatic diseases. (16295470)
2004
32
Good or poor responses of hemostatic molecular markers in patients with hematopoietic disorders after treatment of disseminated intravascular coagulation. (12643327)
2003
33
Trombocytopenia: one of the markers of disseminated intravascular coagulation. (15692253)
2003
34
A case of acute renal failure, rhabdomyolysis and disseminated intravascular coagulation associated with scrub typhus. (12872861)
2003
35
The tissue factor pathway in disseminated intravascular coagulation. (11740684)
2001
36
Osteonecrosis following meningococcemia and disseminated intravascular coagulation in an adult: case report and review. (9114199)
1997
37
Increased but highly dispersed levels of plasma glycocalicin in patients with disseminated intravascular coagulation. (8598238)
1996
38
Current management of disseminated intravascular coagulation. (7993725)
1994
39
Fibrinopeptide A in liver cirrhosis: evidence against a major contribution of disseminated intravascular coagulation to coagulopathy of chronic liver disease. (8426084)
1993
40
Double-blind, placebo-controlled trial of antithrombin III concentrates in septic shock with disseminated intravascular coagulation. (8365305)
1993
41
Therapeutic strategy of newly developing medicines for disseminated intravascular coagulation--activated protein C and thrombomodulin]. (8381887)
1993
42
Disseminated intravascular coagulation in liver cirrhosis. (1447499)
1992
43
Acquired factor X deficiency and disseminated intravascular coagulation in a case of metastasizing carcinoma of the stomach and its course under chemotherapy. (1571411)
1992
44
Coincidence of acquired factor-X deficiency and disseminated intravascular coagulation in patients with acute nonlymphoblastic leukemia. (2049464)
1991
45
Treatment of patients with disseminated intravascular coagulation by protein C. (2316513)
1990
46
Recurrent thromboembolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis associated with protein C deficiency. (3420032)
1988
47
Heparin cofactor II determination--levels in normals and patients with hereditary antithrombin III deficiency and disseminated intravascular coagulation. (6395434)
1984
48
Acute fatty liver of pregnancy with complicating disseminated intravascular coagulation. (6666552)
1983
49
Skeletal lesions following meningococcemia and disseminated intravascular coagulation. A recognizable skeletal dystrophy. (6823928)
1983
50
Meningococcemia without meningitis presenting as cardiac tamponade. Survival with disseminated intravascular coagulation. (5120545)
1971

Genetic Variations for Disseminated Intravascular Coagulation

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Expression for genes affiliated with Disseminated Intravascular Coagulation

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for genes affiliated with Disseminated Intravascular Coagulation

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Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SERPINF2, SERPINE1
210.4ELANE, SERPINC1, F9
310.4THBD, F2, PROC
4
Hide members
10.4THPO, F2, FGA
510.4F9, PROC, F2
6
Hide members
10.4F2, F3, PROC, F9
7
Hide members
10.3SERPINC1, THBD, F2, F3, FGA, PROC
8
Hide members
10.3F9, PPBP, F5, PROC, PF4
9
Hide members
10.3PPBP, F5, PF4, FGA, SERPINE1, SERPINF2
10
Hide members
10.3FGA, F3, F2, THBD, THPO, SERPINE1
11
Hide members
10.2F9, F5, PROC, FGA, F3, F2
12
Hide members
10.2F3, FGA, PROC, F5, F9, F2
13
Hide members
10.2SERPINF2, SERPINC1, SERPINE1, THBD, F2, F3

Compounds for genes affiliated with Disseminated Intravascular Coagulation

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1ancrod4410.8F5, FGA, F2, THBD, SERPINE1, SERPINC1
2epsilon aminocaproic acid4410.7F9, F3, F2, SERPINE1, SERPINC1, SERPINF2
3kininogen4410.7SERPINF2, F9, F5, F3, F2, SERPINE1
4fibrinopeptide a4410.7PF4, FGA, F2, THBD, SERPINC1, SERPINF2
5serine4410.7F9, CAMP, FGA, TAT, ADAMTS13
6ptca4410.7FGA, THBD, SERPINF2, PF4, PPIC, PPBP
7danaparoid4410.7TNXA, F5, PF4, F3, SERPINC1, F2
8argatroban44 1111.7TNXA, F5, FGA, F3, F2, THBD
9bivalirudin44 1111.7SERPINC1, THBD, TNXA, F5, FGA, F3
10hirugen4410.7FGA, F2, SERPINC1, F5, THBD
11ximelagatran44 1111.7THBD, F5, SERPINC1, F2, F3
12warfarin44 49 11 2413.7FGA, SERPINC1, PF4, PROC, F9, PPIC
13fondaparinux4410.7F9, TNXA, F5, PF4, F3, F2
14heparinoids4410.7F3, F2, SERPINC1, F5, THBD
15protamine sulfate4410.7F3, F5, PF4, TAT, F2, SERPINC1
16ristocetin4410.7SERPINF2, ADAMTS13, SERPINC1, F2, F9, PPBP
17dermatan sulfate4410.7F9, TNXA, F5, PF4, F3, F2
18protamine4410.7TNXA, F5, PF4, FGA, F3, F2
1911-dehydrothromboxane b24410.6PF4, FGA, F2, THBD, SERPINE1, PPBP
20endotoxin4410.6F9, CAMP, TNXA, F5, FGA, F3
21desmopressin44 59 28 1113.6F9, PPBP, F5, F3, F2, THBD
22gamma-carboxyglutamic acid4410.6F9, TNXA, F5, PROC, PF4, F3
23ticlopidine44 1111.6PF4, FGA, SERPINC1, ADAMTS13, PPBP, F3
24iloprost44 59 28 1113.6F3, SERPINC1, CAMP, THBD, PPBP, PF4
25coumarin44 2 49 2413.6F9, SERPINC1, F2, F3, FGA, F5
26Drotrecogin alfa1110.6F2, PF4, SERPINE1, THBD, F5
27citrate4410.6PPBP, PF4, SERPINC1, THBD, ELANE, F5
28aprotinin44 1111.6PPBP, F5, PF4, FGA, F3, THBD
29pge14410.6FGA, SERPINE1, F2, F5, PF4, CAMP
30tranexamic acid44 1111.6SERPINC1, SERPINE1, F2, F3, F9
31heparin44 28 11 2413.6TAT, THPO, ADAMTS13, ELANE, FGA, PF4
32hirudin4410.5F9, TNXA, F5, PF4, FGA, F3
33prostacyclin4410.5ELANE, SERPINC1, SERPINE1, THPO, CAMP, PF4
34aspirin44 49 28 2413.5ELANE, SERPINC1, SERPINE1, PPBP, F5, PF4
35epinephrine44 11 2412.5SERPINF2, THPO, F2, F3, ELANE, PPBP
36polysaccharide4410.5F5, PF4, F3, THPO, SERPINC1, THBD
37dipyridamole44 59 28 1113.5PPBP, SERPINE1, PF4, FGA, F3, F2
38creatinine4410.5F2, F9, TNXA, PPBP, F5, PF4
39phospholipid4410.5F5, TNXA, PROC, CAMP, F3, THBD
40txb24410.5FGA, THBD, PPBP, PF4, SERPINF2, F3
41alanine4410.4F3, F2, THBD, THPO, SERPINC1, PPBP
42adp44 28 2412.4SERPINF2, PF4, PPBP, PROC, FGA
43homocysteine44 2411.4F2, F3, F5, F9, SERPINC1, THBD
44inogatran4410.4F2, SERPINC1, F3, F5
45vegf4410.4PPBP, CAMP, F3, F5, PF4, THBD
466-ketoprostaglandin f1alpha4410.4SERPINF2, FGA, PF4, PPBP, THBD
47benzamidine44 1111.4F5, F9, SERPINC1, THBD, ELANE
48fibrinogen4410.3F9, ADAMTS13, ELANE, PPIC, TNXA, SERPINF2
49cacl24410.2THBD, F9, F5, FGA, F3
50dextran sulfate4410.1F5, F9, ELANE

GO Terms for genes affiliated with Disseminated Intravascular Coagulation

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16Gene Ontology
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Cellular components related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.4F2, PROC, F9
2platelet alpha granule lumenGO:03109310.4SERPINF2, PPBP, F5, PF4, FGA, SERPINE1
3extracellular spaceGO:00561510.2PPBP, F5, PF4, FGA, F3, F2
4cell surfaceGO:00998610.2FGA, F3, THBD, SERPINF2, TSPAN32, ADAMTS13
5fibrinogen complexGO:00557710.1SERPINF2, FGA
6extracellular regionGO:00557610.1PROC, F5, PPBP, CAMP, F9, PF4

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.6F2, THBD, SERPINE1, SERPINF2
2peptidyl-glutamic acid carboxylationGO:01718710.6F2, PROC, F9
3negative regulation of blood coagulationGO:03019510.6SERPINE1, THBD, PROC
4fibrinolysisGO:04273010.6F2, SERPINE1, SERPINF2
5negative regulation of plasminogen activationGO:01075710.5SERPINE1, SERPINF2
6platelet degranulationGO:00257610.5PPBP, F5, PF4, FGA, SERPINE1, SERPINF2
7leukocyte migrationGO:05090010.5ELANE, THBD, F2, PROC
8blood coagulation, extrinsic pathwayGO:00759810.5F3, F9
9platelet activationGO:03016810.4PPBP, F5, PF4, FGA, F2, THPO
10positive regulation of blood coagulationGO:03019410.4SERPINE1, F2
11negative regulation of endopeptidase activityGO:01095110.4SERPINF2, SERPINC1, SERPINE1
12blood coagulationGO:00759610.4SERPINF2, F9, PPBP, F5, PROC, PF4
13proteolysisGO:00650810.2F9, PROC, F2, ADAMTS13, ELANE
14negative regulation of platelet activationGO:01054410.1THBD, F2

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.4SERPINF2, SERPINC1, SERPINE1
2protease bindingGO:00202010.2ELANE, SERPINF2, SERPINC1, SERPINE1, F3
3serine-type endopeptidase activityGO:00425210.1F9, PROC, F2, ELANE

Products for genes affiliated with Disseminated Intravascular Coagulation

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Disseminated Intravascular Coagulation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet