MCID: DSS009
MIFTS: 52

Disseminated Intravascular Coagulation malady

Immune diseases, Blood diseases categories

Aliases & Classifications for Disseminated Intravascular Coagulation

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 33MeSH, 39NCIt, 27ICD9CM, 56SNOMED-CT, 25ICD10
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Aliases & Descriptions for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 8 10 44 61
Defibrination Syndrome 8
 
Diffuse 8
Dic 8


Classifications:



External Ids:

Disease Ontology8 DOID:11247
MeSH33 D004211
NCIt39 C2992
SNOMED-CT56 267563002, 67406007
ICD9CM27 286.6
ICD1025 D65

Summaries for Disseminated Intravascular Coagulation

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Wikipedia:64 Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or... more...

MalaCards based summary: Disseminated Intravascular Coagulation, also known as defibrination syndrome, is related to purpura and thrombotic thrombocytopenic purpura. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Selected targets of C EBPalpha and FOXA2 and FOXA3 transcription factor networks. The drugs antithrombin iii, human and antithrombin iii,recombinant and the compounds certoparin and heparin sodium have been mentioned in the context of this disorder. Affiliated tissues include liver, prostate and bone, and related mouse phenotypes are liver/biliary system and integument.

Related Diseases for Disseminated Intravascular Coagulation

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Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 293)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.5SERPINC1, ADAMTS13
2thrombotic thrombocytopenic purpura31.3ADAMTS13
3meningococcemia31.2THBD, SERPINC1, F5
4placental abruption31.1SERPINC1, F5
5hepatitis31.1F2, TAT
6acute respiratory distress syndrome31.1THBD, ELANE
7malaria31.0ADAMTS13, TAT
8coronary thrombosis30.9SERPINC1, F3
9hemolytic-uremic syndrome30.9THBD, ADAMTS13
10hemolytic anemia30.8ADAMTS13, F3
11hemophilia b30.7F3, F2
12factor x deficiency30.6F2, F3, F5
13atrial fibrillation30.5FGA, F2
14liver disease30.5F2, SERPINC1, F3, F5
15hellp syndrome30.4SERPINC1, ADAMTS13, F5
16protein c deficiency30.4F2, THBD, SERPINC1, F5
17portal vein thrombosis30.4F2, SERPINC1, F5
18lupus erythematosus30.4F2, THBD, SERPINC1, F3, F5
19liver cirrhosis30.4F2, SERPINC1, ADAMTS13, F3, TAT
20protein s deficiency30.3F2, SERPINC1, F3, F5, FGA
21pulmonary embolism30.3F2, SERPINC1, F3, F5, FGA
22acute myocardial infarction30.0THBD, SERPINC1, ADAMTS13, F3, FGA
23systemic lupus erythematosus30.0FGA, F3, ADAMTS13, THBD, F2
24hemorrhagic disease29.9F3, SERPINC1, THBD, F2, F5
25vasculitis29.9F2, THBD, ELANE, TAT, FGA
26antiphospholipid syndrome29.8F2, THBD, SERPINC1, ADAMTS13, F3, F5
27thrombocytopenia29.7F2, THBD, SERPINC1, ADAMTS13, F3, F5
28myocardial infarction29.7SERPINC1, ADAMTS13, F3, F5, TAT, FGA
29deficiency anemia29.5TAT, F3, ADAMTS13, F2
30leukemia10.9
31aneurysm10.9
32prostatitis10.8
33prostate cancer10.7
34aortic aneurysm10.7
35pancreatitis10.7
36pneumonia10.6
37adult-onset still's disease10.6
38endocarditis10.6
39dissecting aortic aneurysm10.6
40endotheliitis10.6
41acute leukemia10.6
42cerebritis10.6
43adenocarcinoma10.6
44tuberculosis10.6
45meningococcal infection10.6
46sneddon syndrome10.5SERPINC1
47pancreatic cancer10.5
48thyroiditis10.5
49bone marrow necrosis10.5
50hemorrhagic fever10.5

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to disseminated intravascular coagulation

Symptoms for Disseminated Intravascular Coagulation

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Drugs & Therapeutics for Disseminated Intravascular Coagulation

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Drug clinical trials:

Search ClinicalTrials for Disseminated Intravascular Coagulation

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS61/NDF-RT40:

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Genetic Tests for Disseminated Intravascular Coagulation

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Anatomical Context for Disseminated Intravascular Coagulation

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MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

31
Liver, Prostate, Bone, Neutrophil, Testes, Bone marrow, Kidney, Endothelial, Brain, Heart, Thyroid, Spleen, Colon, Lung, Breast, T cells, Skin, Monocytes, B cells, Whole blood, Placenta, Myeloid, Tongue

Animal Models for Disseminated Intravascular Coagulation or affiliated genes

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MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7FGA, F5, SERPINC1, THBD
2MP:00107718.1FGA, F2, THBD, F3, F5
3MP:00053807.9F3, FGA, F5, SERPINC1, THBD, F2
4MP:00053857.8SERPINC1, THBD, F2, F5, FGA, F3
5MP:00036317.7F2, THBD, SERPINC1, F3, FGA, F5
6MP:00028737.7ELANE, F3, THBD, F2, ADAMTS13
7MP:00053977.3THBD, SERPINC1, F2, F3, ELANE, ADAMTS13
8MP:00053877.3FGA, ELANE, F2, F3, ADAMTS13, THBD
9MP:00053766.7FGA, F5, ELANE, F3, F2, ADAMTS13
10MP:00107686.7SERPINC1, FGA, ELANE, F5, F3, F2

Publications for Disseminated Intravascular Coagulation

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Articles related to Disseminated Intravascular Coagulation:

(show top 50)    (show all 787)
idTitleAuthorsYear
1
Successful treatment with recombinant thrombomodulin for disseminated intravascular coagulation complicated with hemophagocytic syndrome. (25876785)
2015
2
Management of cancer-associated disseminated intravascular coagulation: guidance from the SSC of the ISTH: reply. (25854143)
2015
3
Intrapartum anti-disseminated intravascular coagulation therapy leading to successful vaginal delivery following intrauterine fetal death caused by placental abruption: a case report. (25532532)
2014
4
Complement, thrombotic microangiopathy and disseminated intravascular coagulation. (25705421)
2014
5
Disseminated intravascular coagulation does not play a major role in the pathogenesis of classical swine fever. (23107658)
2013
6
Current consideration and management of disseminated intravascular coagulation. (24319193)
2013
7
Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. (23361628)
2013
8
The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation]. (22225506)
2012
9
The utility of a diagnostic scoring system for disseminated intravascular coagulation. (22713612)
2012
10
Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature. (22844549)
2012
11
Kocher-DebrAc-SAcmAclaigne syndrome diagnosed by autopsy associated with disseminated intravascular coagulation. (21316996)
2012
12
Effects of antithrombin and gabexate mesilate on disseminated intravascular coagulation: a preliminary study. (22204993)
2012
13
Successful treatment of sepsis-induced disseminated intravascular coagulation in a patient with idiopathic thrombocytopenic purpura using recombinant human soluble thrombomodulin. (21240494)
2011
14
Disseminated Intravascular Coagulation, Hemoperitoneum, and Reversible Ischemic Neurological Deficit Complicating Anaphylaxis to Prophylactic Antibiotics during Cesarean Delivery: A Case Report and Review of Literature. (23705078)
2011
15
Model-based analysis of covariate effects on population pharmacokinetics of thrombomodulin alfa in patients with disseminated intravascular coagulation and normal subjects. (21098690)
2011
16
A difficult diagnosis case of prolonged thrombocytopenia with sepsis and disseminated intravascular coagulation. (20530051)
2011
17
Disseminated intravascular coagulation with intracranial haematoma in neonatal congenital syphilis. (20889622)
2011
18
Multiple organ infarctions following disseminated intravascular coagulation precipitated by sepsis in a healthy infant: a case report. (21186015)
2010
19
Disseminated intravascular coagulation complicating Epstein-Barr virus infection in a cardiac transplant recipient: a case report. (20620559)
2010
20
Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism. (20412432)
2010
21
Successful treatment of disseminated intravascular coagulation in a child with acute myelogenous leukaemia using recombinant thrombomodulin. (20346017)
2010
22
Disseminated intravascular coagulation in infectious disease. (20614389)
2010
23
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. (19062078)
2009
24
Pathophysiology and diagnostic criteria for disseminated intravascular coagulation associated with sepsis. (18158452)
2008
25
Anti-heparin/PF4 complexes by ELISA in patients with disseminated intravascular coagulation. (20224256)
2007
26
Case report: Disseminated intravascular coagulation as the presenting sign of metastatic prostate cancer. (17458572)
2007
27
Diagnosis and treatment of disseminated intravascular coagulation: a case report. (17604485)
2007
28
Thrombin generation by exposure of blood to endotoxin: a simple model to study disseminated intravascular coagulation. (16708116)
2006
29
Patient with disseminated intravascular coagulation as the first manifestation of adenocarcinoma of the prostate. Risks of prostatic biopsy. (16331297)
2006
30
A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis. (16988545)
2006
31
Disseminated Intravascular Coagulation syndrome - ENT surgeon's perspective. (23120357)
2006
32
Disseminated intravascular coagulation in cats. (17186846)
2006
33
Disseminated intravascular coagulation after laparoscopic multiple myomectomy with use of icodextrin: a case report. (16962537)
2006
34
Settling the score for disseminated intravascular coagulation. (16215405)
2005
35
Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation. (16363239)
2005
36
Good or poor responses of hemostatic molecular markers in patients with hematopoietic disorders after treatment of disseminated intravascular coagulation. (12643327)
2003
37
Disseminated intravascular coagulation]. (12806952)
2003
38
Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation. (14518675)
2003
39
Etiopathophysiology of disseminated intravascular coagulation. (14651143)
2003
40
Current drug treatment strategies for disseminated intravascular coagulation. (9617592)
1998
41
Antithrombin III in the treatment of disseminated intravascular coagulation]. (9045459)
1997
42
The antithrombotic effects of recombinant human soluble thrombomodulin (rhsTM) on tissue factor-induced disseminated intravascular coagulation in crab-eating monkeys (Macaca fascicularis). (9282791)
1997
43
Disseminated intravascular coagulation associated with granulocyte colony-stimulating factor therapy in a child with human immunodeficiency virus infection. (7538574)
1995
44
Phaeochromocytoma crisis in Sipple's syndrome with intrauterine death and disseminated intravascular coagulation. (15636849)
1993
45
Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report]. (1602615)
1992
46
Disseminated intravascular coagulation in liver cirrhosis. (1447499)
1992
47
The specific activity of plasminogen activator inhibitor-1 in disseminated intravascular coagulation with acute promyelocytic leukemia. (1708294)
1991
48
Disseminated intravascular coagulation masking neonatal hemophilia]. (2039186)
1991
49
Disseminated intravascular coagulation in dissecting aortic aneurysm. A case report. (7290724)
1981
50
Acute disseminated intravascular coagulation as the presenting and predominant clinical manifestation in a patient with a mucinous adenocarcinoma. (4376755)
1974

Variations for Disseminated Intravascular Coagulation

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Expression for genes affiliated with Disseminated Intravascular Coagulation

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Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for genes affiliated with Disseminated Intravascular Coagulation

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Compounds for genes affiliated with Disseminated Intravascular Coagulation

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Compounds related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1certoparin449.5SERPINC1, F3, F2
2heparin sodium449.4THBD, F3, F2
3polybrene449.4F3, F2, SERPINC1
4hepaplastin449.3F2, SERPINC1, F3
5hemochron449.3F2, FGA, F3
6fibrinopeptide a449.1F2, THBD, SERPINC1, FGA
7epsilon aminocaproic acid449.1F3, SERPINC1, ELANE, F2
8ppack449.1SERPINC1, FGA, F2, F3
9benzamidine44 1110.0THBD, ELANE, F5, SERPINC1
10inogatran449.0SERPINC1, F5, F2, F3
11ecarin449.0F2, SERPINC1, F3, F5
12spectrozyme449.0F3, F5, F2, SERPINC1
13danaparoid449.0F2, SERPINC1, F3, F5
14rivaroxaban44 1110.0F2, SERPINC1, F3
15kaolin449.0F2, F3, F5
16cacl2448.9FGA, F5, F3, THBD
17nafamostat mesilate448.9ELANE, F5, SERPINC1, FGA
18gamma-carboxyglutamic acid448.9F5, F3, F2, THBD
19levonorgestrel44 60 28 1111.9F2, F3, SERPINC1, F5
20batroxobin448.8F2, F5, FGA
21cardiolipin44 119.8F2, THBD, F3, F5
22heparinoids448.7F5, F3, SERPINC1, THBD, F2
23ximelagatran44 119.7F5, F3, SERPINC1, THBD, F2
24ticlopidine44 119.7FGA, ADAMTS13, F3, SERPINC1
25fondaparinux448.7F2, F5, F3, SERPINC1, THBD
26protamine sulfate448.6TAT, SERPINC1, F2, F3, F5
27dextran sulfate448.6ELANE, SERPINC1, F3, F5
28hirugen448.6F2, FGA, F5, SERPINC1, THBD
29ancrod448.6FGA, F5, SERPINC1, THBD, F2
30homocysteine44 249.6F2, SERPINC1, F5, F3, THBD
31coumarin44 1 50 2411.5FGA, F5, F3, SERPINC1, F2
32dermatan sulfate448.3F5, SERPINC1, ELANE, F3, F2, THBD
33kininogen448.2F3, SERPINC1, ELANE, F5, THBD, F2
34ristocetin448.2F2, SERPINC1, F5, ADAMTS13, F3
35argatroban44 119.2SERPINC1, F2, THBD, FGA, F5, F3
36bivalirudin44 119.2SERPINC1, FGA, F5, F3, THBD, F2
37citrate448.2F2, THBD, SERPINC1, F3, ELANE, F5
38hirudin448.2F2, THBD, SERPINC1, F3, F5, FGA
39warfarin44 50 24 1111.2F3, F5, FGA, F2, SERPINC1, THBD
40prostacyclin448.2THBD, FGA, F5, ELANE, F3, SERPINC1
41protamine448.1SERPINC1, F3, F2, F5, FGA, ELANE
42desmopressin44 60 28 1110.9F2, ADAMTS13, F3, F5, THBD, SERPINC1
43lactate447.8F2, THBD, ELANE, FGA, TAT, F5
44aprotinin44 118.8FGA, F5, ELANE, F3, SERPINC1, THBD
45aspirin44 50 28 2410.7THBD, SERPINC1, F5, F2, FGA, F3
46endotoxin447.7THBD, FGA, F3, ELANE, F5, ADAMTS13
47creatinine447.3FGA, F5, F3, ADAMTS13, THBD, F2
48fibrinogen446.5THBD, SERPINC1, ADAMTS13, F3, ELANE, F5
49heparin44 28 24 119.5F2, THBD, SERPINC1, ADAMTS13, F3, ELANE
50serine446.4F2, F5, FGA, TAT, ELANE, F3

GO Terms for genes affiliated with Disseminated Intravascular Coagulation

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Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.3FGA, F5
2blood microparticleGO:00725629.1F2, SERPINC1, FGA
3cell surfaceGO:00099868.0FGA, ELANE, F3, ADAMTS13, THBD
4extracellular regionGO:00055767.9FGA, F5, ELANE, SERPINC1, F2
5plasma membraneGO:00058867.5F2, THBD, SERPINC1, F3, F5, FGA
6extracellular spaceGO:00056157.1FGA, F2, THBD, SERPINC1, ADAMTS13, F3

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:00507289.7ELANE, SERPINC1
2negative regulation of platelet activationGO:00105449.6THBD, F2
3negative regulation of fibrinolysisGO:00519189.5THBD, F2
4leukocyte migrationGO:00509009.2F2, THBD, ELANE
5proteolysisGO:00065088.4F2, ADAMTS13, ELANE
6platelet activationGO:00301688.1FGA, F5, ADAMTS13, F2
7blood coagulationGO:00075967.9FGA, F2, THBD, SERPINC1, F3, F5

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.2ELANE, F3, SERPINC1
2serine-type endopeptidase activityGO:00042528.9F5, ELANE, F2
3protein bindingGO:00055156.2F2, THBD, SERPINC1, ADAMTS13, F3, ELANE

Sources for Disseminated Intravascular Coagulation

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet