Disseminated Intravascular Coagulation malady

Wikipedia: Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or...⁴⁴ more...

MalaCards: Disseminated Intravascular Coagulation, also known as disseminated intravascular coagulation (disorder), is related to sepsis and acute fatty liver of pregnancy. An important gene associated with Disseminated Intravascular Coagulation is PPIC (peptidylprolyl isomerase C (cyclophilin C)), and among its related pathways are Warfarin Pathway, Pharmacodynamics and Common Pathway. The drugs antithrombin iii,human and antithrombin iii,recombinant and the compounds argatroban and ancrod have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and liver, and related mouse phenotypes are respiratory system and renal/urinary system.

Aliases & Descriptions:

disseminated intravascular coagulation 6 8 32 43 disseminated intravascular coagulation (disorder) 6 dissemin. intravascular coag. 6

defibrination syndrome 6 diffuse 6 dic 6

Diseases related to disseminated intravascular coagulation by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1045)

id	Related Disease	Score	Top Affiliating Genes
1	sepsis	36.0	CD14, IL10, TNF
2	acute fatty liver of pregnancy	33.2	SERPINC1, F3, F2
3	thrombosis	33.1	F8, F5, F2
4	acute promyelocytic leukemia	33.0	RARA, MPO, ANXA2, F3, ELANE, THBD
5	diffuse large b-cell lymphoma	32.8	SELE, VEGFA, CD14, CD40LG, IL10, IL1B
6	hepatitis	32.3	VTN, GPT, IFNA1
7	diffuse panbronchiolitis	31.6	MPO, IL1B, TNF, ELANE
8	b-cell lymphomas	31.5	SELE, VEGFA, MPO, CD14, CD40LG, FN1
9	meningococcemia	31.4	SERPINC1, SERPINE1, LIF, IL1B, F5, THBD
10	panbronchiolitis	31.3	MPO, IL1B, TNF, ELANE
11	liver cirrhosis	31.3	VTN, SERPINC1, SERPINF2, LIF, LBP, CD14
12	hemophilia b	30.9	VWF, F9, F8, F7, F3, F2
13	scrub typhus	30.8	CD40LG, GPT, F3, CRP
14	typhus	30.8	CD40LG, GPT, F3, CRP
15	acquired immunodeficiency syndrome	30.8	CD14, FGA, F9, F8, F13A1, PPBP
16	heparin-induced thrombocytopenia	30.3	SELE, SERPINC1, SERPINE1, CD40LG, GPT, GP1BA
17	protein s deficiency	30.3	PIK3C2A, SERPINC1, SERPINE1, FGA, IFNA1, F9
18	thromboembolism	30.0	VWF, SERPINC1, SERPINF2, SERPIND1, SERPINE1, FGA
19	head injury	29.8	IL1B, IL6, F3, F2, ELANE, SOD1
20	hypofibrinogenemia	29.8	VWF, SERPINC1, SERPINF2, SERPINE1, FGA, F3
21	septic shock	29.3	PIK3C2A, SELE, SERPINC1, SERPINE1, VDAC1, LIF
22	immunodeficiency	29.1	CD40LG, MIF, IL10, IL6, IFNA1, HMGB1
23	cryptococcosis	29.0	CD40LG, IL10, IL6, F3, F2, TNF
24	hyperinsulinism	29.0	SELE, SERPINE1, F7, SULT1A3, EDN1, OXT
25	meningoencephalitis	28.9	CD40LG, IL6, GPT, F3, TNF, CRP
26	goiter	28.8	SELE, VEGFA, IL1B, CXCL10, SOD1, HGF
27	microscopic polyangiitis	28.7	SELE, MPO, IL10, MB, F2, TNF
28	multiple myeloma	28.4	VTN, FN1, IL6
29	idiopathic interstitial pneumonia	28.1	SERPINE1, VEGFA, EDN1, ELANE, THBD
30	follicular lymphoma	28.1	VEGFA, FDPS, IL10, IFNA1, IFNA2, F2
31	mediastinitis	27.9	SELE, MPO, IL6, IFNA2, F5, F3
32	malignant mesothelioma	27.5	VEGFA, IL10, IL6, IFNA2, PDPN, THBD
33	arthritis	27.3	IL1B, IL6, TNF, CTSB
34	pulmonary edema	27.2	PIK3C2A, SERPINC1, VEGFA, IL1B, IL6, F2
35	polycythemia vera	27.1	VWF, SERPINC1, SERPINE1, MPO, IL11, IL6
36	burkitt's lymphoma	27.0	RARA, CD40LG, IL10, IFNA1, F2, TNF
37	cutaneous leishmaniasis	27.0	PIK3C2A, IL10, IL6, GPT, TNF, SOD1
38	hemophilia	27.0	VWF, SERPINC1, CD40LG, IL10, IL1B, IL6
39	osteosclerosis	26.9	VEGFA, CD40LG, IL11, IFNA2, THPO
40	periventricular leukomalacia	26.7	VEGFA, IL1B, IL6, TNF
41	leukomalacia	26.7	VEGFA, IL1B, IL6, TNF
42	mastocytosis	26.7	RARA, MPO, IL1B, IFNA1, IFNA2, F3
43	astrocytoma	26.6	VTN, SERPINE1, VEGFA, RARA, LBP, FN1
44	hemolytic-uremic syndrome	26.5	VWF, SERPINC1, SERPINE1, CD40LG, IL10, IL1B
45	acute liver failure	26.4	GPT, F2, THPO, HGF
46	schistosomiasis	26.4	VWF, SELE, SERPINC1, SERPINF2, SERPINE1, CD40LG
47	myocarditis	26.4	PIK3C2A, SERPINC1, MPO, CD40LG, FGA, IL10
48	giant cell tumor	26.3	VEGFA, CD14, IL1B, F13A1, TNF, CTSB
49	bacterial meningitis	26.2	PIK3C2A, LBP, IL1B, CRP
50	cellulitis	26.1	F10, CAMP, TNF, CRP, CSF3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 antithrombin iii, antithrombin iii,human, antithrombin iii,recombinant

MalaCards organs/tissues related to disseminated intravascular coagulation:

²²

MGI Mouse Phenotypes related to disseminated intravascular coagulation:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	CPB2, F13A1, MB, CD14, LIF
2	renal/urinary system phenotype	MP:0005367	9.9	CPB2, OXT, PLG, CTSB, RARA, NAGLU
3	integument phenotype	MP:0010771	9.4	CSF3, OXT, TFPI, PDPN, CTSB, F2
4	hematopoietic system phenotype	MP:0005397	9.2	SERPIND1, MIF, MB, GP1BA, F13A1, THPO
5	nervous system phenotype	MP:0003631	9.1	PLG, EDN1, THBD, TFPI, PROC, CXCL10
6	skeleton phenotype	MP:0005390	9.1	TFPI, PDPN, PLAT, IL6, FGA, FN1
7	digestive/alimentary phenotype	MP:0005381	8.8	OXT, EDN1, PDPN, PLG, PLAT, CTSB
8	liver/biliary system phenotype	MP:0005370	8.8	SOD1, PLG, F9, IL6, FGA, LBP
9	growth/size phenotype	MP:0005378	8.4	HMGB1, CTSB, PLAT, PLG, PDPN, AGER
10	reproductive system phenotype	MP:0005389	8.0	IL6, F8, F10, TNF, PLG, OXT
11	immune system phenotype	MP:0005387	7.9	ELANE, AGER, TSPAN32, TFPI, PROC, CXCL10
12	tumorigenesis	MP:0002006	7.7	TNF, CTSB, PLG, ELANE, CPB2, F3
13	vision/eye phenotype	MP:0005391	7.0	IL6, F3, HMGB1, TNF, PLAT, PLG
14	mortality/aging	MP:0010768	6.8	OXT, PROC, CPB2, ADAMTS13, TFPI, THBD
15	muscle phenotype	MP:0005369	6.7	TNF, PLAT, PDPN, EDN1, AGER, PROC
16	cellular phenotype	MP:0005384	5.1	PLAT, CTSB, TNF, HMGB1, F2, PLG
17	homeostasis/metabolism phenotype	MP:0005376	5.0	PIK3C2A, F9, F8, F7, F5, F3
18	cardiovascular system phenotype	MP:0005385	4.1	VWF, SELE, SERPINC1, F10, F13A1, TNF

Articles related to disseminated intravascular coagulation:

(show top 50)    (show all 191)

id	Title	Authors	Year	Affiliating Genes
1	Circulating hepatocyte growth factor as an independen t prognostic factor of disseminated intravascular coagulation. (20185166)	Chung S.... Kim H.K.	2010	HGF
2	Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation. (19162307)	Hyun J.... Cho H.I.	2009	ADAMTS13
3	Plasma level of stromal derived factor-1 (SDF-1) is increased in disseminated intravascular coagulation patients who have poor outcomes: in vitro effect of SDF-1 on coagulopathy. (17239427)	Kim H.K.... Cho H.I.	2007	F3, THBD, CXCL12
4	Place of antithrombin III concentrate in the intensive care of disseminated intravascular coagulation (17563999)	Vorob'eva N.A.... Mel'nikova G.N.	2007	SERPINC1
5	Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. (17890943)	Franchini M.... Lippi G.	2007	F7
6	Frequency of abnormal biphasic aPTT clot waveforms in patients with underlying disorders associated with disseminated intravascular coagulation. (16708120)	Matsumoto T.... Shiku H.	2006	F3
7	Evaluation of haemostatic molecular markers for diagnosis of disseminated intravascular coagulation in patients with infections. (16493490)	Asakura H.... Gando S.	2006	PPIC
8	A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis. (16988545)	Wiedermann C.J.... Kaneider N.C.	2006	SERPINC1
9	International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients. (16905947)	Voves C.... Zeerleder S.	2006	F2
10	The Leiden mutation and activated protein C resistance as risk factors for disseminated intravascular coagulation in acutely poisoned patients. (16496494)	Prazanowski M.... Kolacinski Z.	2006	F5
11	Disseminated intravascular coagulation in sepsis. (16236964)	Zeerleder S.... Wuillemin W.A.	2005	SERPINC1
12	Plasma soluble fibrin monomer complex is a useful predictor of disseminated intravascular coagulation in neonatal sepsis. (15749684)	Selim T.E.... Rakha S.A.	2005	SERPINC1, F5
13	Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation. (16244764)	Matsumoto T.... Matsuda M.	2005	ELANE, PPIC
14	Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. (16215373)	Kinasewitz G.T.... Taylor F.B.	2005	F2
15	The prothrombin time point of the disseminated intravascular coagulation score. (15942407)	Kountchev J.... Joannidis M.	2005	F2
16	Blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation in acute-poisoned patient s (15690701)	BaraA8ska M.... Lutz W.	2004	F5
17	Disseminated intravascular coagulation, perimyocarditis and bilateral pleural empyema in adult Still's disease (15543470)	Krzossok S.... Braun C.	2004	CRP
18	Disseminated intravascular coagulation (12806952)	Iba T.... Kidokoro A.	2003	SERPINC1
19	Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation. (14518675)	Saito T.... Yoshimura K.	2003	F2
20	Transmittance waveform of routine coagulation tests is a sensitive and specific method for diagnosing non-overt disseminated intravascular coagulation. (12918782)	Toh C.H.	2002	F3
21	Pathogenesis and treatment of disseminated intravascular coagulation in the septic patient. (11815902)	Levi M.	2001	SERPINC1
22	Effect of activated human protein C on disseminated intravascular coagulation induced by lipopolysaccharide in rats. (11050697)	Aoki Y.... Nakagaki T.	2000	F5, THBD, GPT
23	Disseminated intravascular coagulation (DIC). (11586511)	Mammen E.F.	2000	SERPINC1
24	Serum thrombomodulin as a prognostic marker of disseminated intravascular coagulation. (10515237)	Kotajima N.... Kobayashi I.	1999	THBD
25	Hemostatic molecular markers before the onset of disseminated intravascular coagulation. (10203100)	Wada H.... Shiku H.	1999	PPIC
26	Current drug treatment strategies for disseminated intravascular coagulation. (9617592)	de Jonge E.... van Deventer S.J.	1998	F3
27	The effect of antithrombin on the systemic inflammatory response in disseminated intravascular coagulation. (10102494)	Nielsen J.D.	1998	SERPINC1
28	Disseminated intravascular coagulation and antithrombin III depression in acute fatty liver of pregnancy. (8572009)	Castro M.A.... McGehee W.G.	1996	SERPINC1
29	High dose of intravenous antithrombin III without heparin in the treatment of disseminated intravascular coagulation and organ failure in four children. (8813091)	Fuse S.... Fujita S.	1996	SERPINC1
30	Plasma tissue factor and tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation. (8756081)	Shimura M.... Shiku H.	1996	F3
31	Characterization of cancer-related disseminated intravascular coagulation in relation to tumor necrosis factor-alpha blood concentrations: possible therapeutic role of pentoxifylline. (8623512)	Lissoni P.... Tancini G.	1996	TNF
32	Soluble thrombomodulin increases in patients with disseminated intravascular coagulation and in those with multiple organ dysfunction syndrome after trauma: role of neutrophil elastase. (7473950)	Gando S.... Nanzaki S.	1995	THBD, ELANE
33	Role of tissue factor in disseminated intravascular coagulation. (8578548)	Asakura H.... Morishita E.	1995	F3
34	Cytokines, soluble thrombomodulin and disseminated intravascular coagulation in patients with systemic inflammatory response syndrome. (8610280)	Gando S.... Nakanishi Y.	1995	TNF, IL1B, THBD
35	Disseminated intravascular coagulation after liver resection: retrospective study in patients with biliary tract carcinoma. (7740431)	Nagino M.... Kanai M.	1995	F2
36	Intravenous extended infusion of recombinant human soluble thrombomodulin prevented tissue factor-induced disseminated intravascular coagulation in rats. (8178801)	Mohri M.... Ishida T.	1994	F3, THBD
37	Mediators of leukocyte activation play a role in disseminated intravascular coagulation during orthotopic liver transplantation. (7509086)	Himmelreich G.... Riess H.	1994	CTSB, F2, ELANE
38	Increased vascular endothelial cell markers in patients with disseminated intravascular coagulation. (8266924)	Wada H.... Hayashi T.	1993	PLAT, SERPINE1, THBD
39	Fibrinopeptide A in liver cirrhosis: evidence against a major contribution of disseminated intravascular coagulation to coagulopathy of chronic liver disease. (8426084)	Mombelli G.... Straub P.W.	1993	FGA
40	Therapeutic strategy of newly developing medicines for disseminated intravascular coagulation--activated protein C and thrombomodulin (8381887)	Maruyama I.	1993	THBD
41	Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. (1531791)	Fourrier F.... Lestavel P.	1992	SERPINC1
42	Disseminated intravascular coagulation syndrome in an orexia nervosa. (1414338)	Katamura K.... Kisa T.	1992	SERPINC1
43	Disseminated intravascular coagulation after factor IX complex resolved using purified factor IX concentrate. (1892334)	Hadley T.... Djulbegovic B.	1991	F9
44	Levels of tissue-type plasminogen activator and plasminogen activator inhibitor 1 in disseminated intravascular coagulation syndrome (1920864)	Fukao H.... Matsuo O.	1991	PLAT, SERPINE1
45	Plasma active renin, inactive renin and kallikrein in patients with disseminated intravascular coagulation. (1680981)	Lai H.S.... Yen T.S.	1991	KLKB1
46	Significance of hemostatic molecular markers during disseminated intravascular coagulation in patients with liver cirrhosis treated by endoscopic embolization for esophageal varices. (1719808)	Koyama T.... Okamoto E.	1991	TAT
47	Treatment of patients with disseminated intravascular coagulation by protein C. (2316513)	Okajima K.... Aoki N.	1990	F5
48	Worsening of chronic disseminated intravascular coagulation after embolization of the renal artery (2331088)	Galet A.... Goudemand J.	1990	F3
49	Treatment of disseminated intravascular coagulation (2214166)	Asakura H.	1990	SERPINC1, F5
50	Thrombin-antithrombin III complex in fulminant hepati c failure: evidence for disseminated intravascular coagulation and relationship to outcome. (2127751)	Langley P.G.... Williams R.	1990	TAT

Genes related to disseminated intravascular coagulation according to GeneCards:

(show top 50)    (show all 80)

id	Symbol	Description	Score	GeneCards Section Context
1	PPIC	peptidylprolyl isomerase C (cyclophilin C)	11.0	Publications
2	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
3	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
4	TNXA	tenascin XA (pseudogene)	11.0
5	THBD	thrombomodulin	11.0	Publications
6	TAT	tyrosine aminotransferase	11.0	Publications
7	TSPAN32	tetraspanin 32	11.0
8	FGA	fibrinogen alpha chain	11.0	Publications
9	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
10	ELANE	elastase, neutrophil expressed	11.0	Publications
11	PROC	protein C (inactivator of coagulation factors Va and VIIIa)	11.0
12	F9	coagulation factor IX	11.0	Publications
13	F2	coagulation factor II (thrombin)	11.0	Publications
14	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
15	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0
16	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
17	THPO	thrombopoietin	11.0	Publications
18	PF4	platelet factor 4	11.0	Publications
19	LBP	lipopolysaccharide binding protein	11.0
20	ANXA2	annexin A2	11.0
21	VDAC1	voltage-dependent anion channel 1	11.0
22	SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	11.0
23	CAMP	cathelicidin antimicrobial peptide	11.0
24	LIF	leukemia inhibitory factor	11.0
25	FN1	fibronectin 1	11.0	Publications
26	MB	myoglobin	11.0
27	RARA	retinoic acid receptor, alpha	11.0
28	OXT	oxytocin, prepropeptide	11.0
29	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0
30	PLAT	plasminogen activator, tissue	11.0	Publications
31	ZFYVE9	zinc finger, FYVE domain containing 9	11.0
32	CD14	CD14 molecule	11.0
33	VTN	vitronectin	11.0
34	F10	coagulation factor X	11.0	Publications
35	F8	coagulation factor VIII, procoagulant component	11.0
36	OTOR	otoraplin	11.0
37	SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	11.0	Publications
38	C1D	C1D nuclear receptor corepressor	11.0	Publications
39	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
40	F13B	coagulation factor XIII, B polypeptide	11.0	Publications
41	KLKB1	kallikrein B, plasma (Fletcher factor) 1	11.0	Publications
42	FDPS	farnesyl diphosphate synthase	11.0
43	SERPINA5	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	11.0
44	CPB2	carboxypeptidase B2 (plasma)	11.0
45	ASRGL1	asparaginase like 1	11.0
46	TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	11.0
47	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	11.0	Publications
48	PDPN	podoplanin	11.0	Publications
49	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
50	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications

Pathways related to disseminated intravascular coagulation according to GeneDecks:

(show top 50)    (show all 64)

id	Pathway	Score	Top Affiliating Genes
1	Warfarin Pathway, Pharmacodynamics34	10.5	PROC, F10, F2, F7, F9
2	Common Pathway38	10.5	F13B, F13A1, F5, SERPINC1
3	Bacterial infections in CF airways41	10.5	CTSB, LBP
4	Platelet activation, signaling and aggregation38	10.2	A2M, PF4, PLG, PPBP, FGA, VWF
5	Extrinsic Prothrombin Activation Pathway36	10.1	F5, F3, F2, F10, F13A1, F13B
6	Cell adhesion_PLAU signaling41	10.0	SERPINA5, SERPINE1, PLAT, PLG, HGF, VTN
7	Cell adhesion PLAU signaling10	10.0	HGF, PLG, PLAT, SERPINE1, SERPINA5, VTN
8	Cell adhesion_ECM remodeling41	10.0	KLK3, PLG, PLAT, FN1, SERPINE1, VTN
9	Cell adhesion ECM remodeling10	10.0	KLK3, PLG, PLAT, FN1, SERPINE1, VTN
10	Cell adhesion_Plasmin signaling41	10.0	KLKB1, PLG, PLAT, FGA, FN1, VEGFA
11	Cell adhesion Plasmin signaling10	10.0	KLKB1, PLG, PLAT, FGA, FN1, VEGFA
12	Intrinsic Prothrombin Activation Pathway36	9.9	SERPINC1, FGA, F9, F8, F5, F2
13	Immune response_TLR signaling pathways41	9.9	CXCL10, IL6, IL11, FN1, CD14, LBP
14	RAR-Gamma-RXR-Alpha Degradation36	9.8	CSF3, CXCL12, PF4, IL11, LIF
15	Selected targets of HNF110	9.8	F8, F13A1, F13B, CRP, PROC
16	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	9.6	CXCL10, IL6, IL11, CD14, LBP
17	Blood Coagulation Cascade36	9.6	F13B, KLK3, KLKB1, THBD, TFPI, PROC
18	Molecular Mechanisms of Cancer36	9.5	HGF, CXCL12, PF4, PPBP, IL6, IL11
19	Immune response_MIF in innate immunity response41	9.4	CD14, MIF, IL1B, IL6, TNF, LBP
20	Immune response MIF in innate immunity response10	9.4	TNF, LBP, CD14, MIF, IL1B, IL6
21	Immune response IL-1 signaling pathway10	9.3	EDN1, TNF, F3, IL6, IL1B, SERPINE1
22	Immune response_IL-1 signaling pathway41	9.3	EDN1, TNF, F3, IL6, IL1B, SERPINE1
23	Cytokine production by Th17 cells in CF (Mouse model)41	9.3	ZFYVE9, LBP, CD14, IL6, CSF3
24	IL-6 Pathway36	9.1	HGF, CSF3, CXCL10, PF4, IL11, IL10
25	Blood Coagulation Signaling Pathways37	9.0	TFPI, PROC, THBD, F5, F3, F2
26	IL-10 Pathway36	8.9	TNF, IL6, IL1B, IL10, CD14
27	Complement and coagulation cascades20	8.9	VWF, F2, F10, F13A1, F13B, PLAT
28	Hematopoietic cell lineage20	8.7	CSF3, THPO, TNF, GP1BA, IL6, IL1B
29	African trypanosomiasis20	8.7	TNF, IL6, IL1B, IL10, SELE
30	Jak-STAT signaling pathway20	8.7	IFNA2, IFNA1, IL11, IL10
31	Toll-like receptor signaling pathway20	8.6	CXCL10, TNF, IFNA2, IFNA1, IL6, IL1B
32	Rheumatoid arthritis20	8.5	CXCL12, TNF, IL6, IL1B, IL11, VEGFA
33	Akt Signaling36	8.5	IL10, IL11, IL6, TNF, PF4, THPO
34	Influenza A20	8.4	CXCL10, PLG, TNF, IFNA2, IFNA1, IL6
35	Rho Family GTPases36	8.4	THPO, CXCL10, CXCL12, CSF3, HGF, PF4
36	Cytokine Network36	8.4	TNF, IFNA2, IFNA1, IL6, IL1B, IL10
37	Endothelin-1 Signaling Pathway36	8.3	CSF3, CXCL12, CXCL10, EDN1, PF4, IL6
38	ERK Signaling36	8.3	CSF3, CXCL12, FN1, IL10, IL11, IL1B
39	Tuberculosis20	8.2	TNF, CAMP, IFNA2, IFNA1, IL6, IL1B
40	JAK-STAT Pathway36	8.0	HGF, CXCL12, THPO, PPBP, F2, IFNA2
41	Malaria20	7.9	HGF, CSF3, TNF, IL6, IL1B, IL10
42	PEDF Induced Signaling36	7.7	HGF, CSF3, CXCL12, CXCL10, PF4, TNF
43	STAT3 Pathway36	7.7	HGF, CSF3, CXCL12, CXCL10, PF4, TNF
44	all-trans-Retinoic Acid Signaling in Brain36	7.6	HGF, CSF3, CXCL12, CXCL10, PF4, TNF
45	PAK Pathway36	7.6	THPO, CXCL10, CXCL12, CSF3, HGF, PF4
46	Antioxidant Action of Vitamin-C36	7.6	HGF, CSF3, CXCL12, CXCL10, THPO, PF4
47	p38 Signaling36	7.6	HGF, CSF3, CXCL12, CXCL10, THPO, PF4
48	MIF Mediated Glucocorticoid Regulation36	7.5	PF4, CXCL10, CXCL12, CSF3, HGF, TNF
49	MIF Regulation of Innate Immune Cells36	7.5	PF4, CXCL10, CXCL12, CSF3, HGF, TNF
50	Cytokine-cytokine receptor interaction20	6.3	TNF, PPBP, PF4, CXCL10, CXCL12, CSF3

Compounds related to disseminated intravascular coagulation according to GeneDecks:

(show top 50)    (show all 436)

id	Compound	Score	Top Affiliating Genes
1	argatroban32 9 9	12.6	THBD, TNXA, F10, F2, F3, F5
2	ancrod32	10.5	SERPINE1, SERPINC1, FGA, F5, THBD, PLAT
3	clopidogrel32 34 9 18 9	14.5	PPBP, TNXA, F10, CD40LG, SERPINC1
4	gamma-carboxyglutamic acid32	10.4	PROC, THBD, PF4, TNXA, F10, F2
5	cyclophosphamide32 34 9 9	13.4	F8, F9
6	bivalirudin32 9 9	12.2	SERPINC1, THBD, PLAT, TNXA, F10, F2
7	tranexamic acid32 9 9	12.2	VWF, PLG, PLAT, F8, F9, SERPINE1
8	ristocetin32	10.1	F8, F9, GP1BA, SERPINF2, SERPINC1, VWF
9	iloprost32 42 9 9	13.1	SELE, SERPINC1, THPO, THBD, EDN1, PF4
10	protamine32	10.0	PF4, PLAT, TNXA, F10, F2, F3
11	lysine32	9.9	TAT, TAF1, THPO, A2M, PF4, TNXA
12	abciximab32 9 9	11.9	CRP, F10, F2, F3, CD40LG, VTN
13	desmopressin32 42 9 9	12.8	SERPINC1, VWF, SERPINF2, SERPINE1, ADAMTS13, OXT
14	tirofiban32 9 9	11.7	PF4, PLAT, CRP, F10, F2, F3
15	hyaluronic acid32 18	10.6	GPT, MB, IL11, FN1, VTN, F2
16	phosphatidylserine32 9 9	11.5	THBD, CTSB, TNXA, HMGB1, F10, F2
17	rituximab32 34 9 9	12.5	F8, F9, IL10, CD40LG, ADAMTS13, CXCL12
18	homocysteine32 18	10.2	THBD, PLAT, CRP, SULT1A3, PIK3C2A, VWF
19	epinephrine32 9 18 9	12.1	MB, IL11, FGA, SERPINF2, SELE, VTN
20	latex32	9.1	THPO, PF4, CRP, PPBP, F8, F9
21	kininogen32	8.9	THBD, ELANE, KLKB1, PF4, PLG, PLAT
22	endotoxin32	8.7	HMGB1, CAMP, F3, F5, F8, F9
23	cysteine32	8.7	ANXA2, MB, IL11, FN1, CD40LG, CD14
24	oxygen32 18	9.6	HGF, TAT, THPO, SERPINF2, PIK3C2A, NAGLU
25	glutamine32	8.5	FN1, CD14, VDAC1, SERPINF2, VTN, VWF
26	sb 20358032 42	9.2	HGF, CXCL12, THPO, EDN1, CRP, TNF
27	ulinastatin32	8.2	SOD1, THBD, ELANE, TNF, IL6, IL10
28	arachidonic acid32 9 18 9	11.1	HGF, OXT, THPO, VWF, VDAC1, LIF
29	hydrocortisone32 9 9	10.0	IL6, IL1B, IL10, MIF, CD14, LIF
30	matrigel32	8.0	HGF, CXCL12, CXCL10, THPO, THBD, PLG
31	norepinephrine32 9 18 9	10.9	F8, MB, IL6, FGA, MIF, CD40LG
32	simvastatin32 34 42 9 18 9	12.5	VWF, PIK3C2A, SELE, SERPINE1, THBD, PLAT
33	atorvastatin32 34 9 18 9	11.4	THBD, EDN1, PLAT, CRP, TNF, F5
34	arginine32	7.3	CPB2, SOD1, OXT, TAT, THBD, EDN1
35	indomethacin32 9 9	9.0	CD40LG, MPO, FN1, HGF, SOD1, TAT
36	heparin32 9 18 9	10.0	HGF, ADAMTS13, CXCL12, PROC, OXT, TAT
37	paraffin32	7.0	FN1, CD40LG, CD14, MPO, LIF, RARA
38	thalidomide32 42 9 9	9.8	HGF, THBD, KLK3, PLG, TNF, IFNA2
39	cholesterol32 9 18 9	9.8	THBD, GPT, ANXA2, IL6, FDPS, FGA
40	histamine32 18	7.5	THBD, MPO, SELE, VWF, CD14, CD40LG
41	prostacyclin32	6.1	THPO, IL10, FGA, ASRGL1, FN1, VEGFA
42	vegf32	5.9	SERPINC1, SELE, VTN, VWF, PIK3C2A, SERPINF2
43	thymidine32 18	6.7	IFNA1, IL6, IL1B, IL11, IL10, FGA
44	tyrosine32	5.6	HGF, F8, F9, IFNA2, IFNA1, GP1BA
45	cyclosporin a32 42	6.5	HGF, ADAMTS13, CSF3, IL11, IL10, FN1
46	nitric oxide32 9 18 9	8.0	THBD, IL11, IL10, MIF, FN1, MPO
47	dexamethasone32 42 34 9 9	8.9	VTN, VWF, HGF, CSF3, IL6, IL1B
48	cycloheximide32	4.8	IFNA1, IL6, IL1B, IL11, IL10, FN1
49	alanine32	4.7	SERPINC1, SELE, VTN, VWF, PIK3C2A, HGF
50	serine32	4.6	C1D, A2M, KLKB1, KLK3, PLG, PLAT

Cellular components related to disseminated intravascular coagulation according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	fibrinogen complex	GO:005577	10.3	SERPINF2, FN1, FGA
2	platelet alpha granule	GO:031091	10.1	VWF, SERPINA5, FGA
3	Golgi lumen	GO:005796	10.0	PROC, F10, F2, F7, F9
4	secretory granule	GO:030141	9.5	OXT, ELANE, PLAT, IL1B, MPO, VEGFA
5	extracellular matrix	GO:031012	9.3	SOD1, PLAT, F3, ANXA2, FN1, SERPINE1
6	cell surface	GO:009986	9.2	ADAMTS13, THBD, ELANE, PLAT, TNF, HMGB1
7	external side of plasma membrane	GO:009897	9.0	CXCL12, CXCL10, CTSB, TNF, FGA, CD40LG
8	platelet alpha granule lumen	GO:031093	8.9	SERPINE1, VEGFA, FN1, FGA, F8, F5
9	plasma membrane	GO:005886	6.9	F3, F2, F10, TNF, PLG, PDPN
10	extracellular region	GO:005576	3.9	VEGFA, F2, F10, F13A1, F13B, CAMP
11	extracellular space	GO:005615	2.6	VTN, IL10, IL11, IL1B, IL6, IFNA2

Biological processes related to disseminated intravascular coagulation according to GeneDecks:

(show all 40)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptidyl-glutamic acid carboxylation	GO:017187	10.5	PROC, F10, F2, F7, F9
2	negative regulation of blood coagulation	GO:030195	10.5	PROC, THBD, EDN1, SERPINE1, VTN
3	blood coagulation, extrinsic pathway	GO:007598	10.5	TFPI, F10, F3, F7, F9
4	negative regulation of fibrinolysis	GO:051918	10.5	CPB2, THBD, PLG, F2, SERPINE1, SERPINF2
5	positive regulation of leukocyte chemotaxis	GO:002690	10.4	F7, CXCL10
6	positive regulation of blood coagulation	GO:030194	10.4	SERPINE1, F7, F2
7	negative regulation of proteolysis	GO:045861	10.3	SERPINA5, F2, PLAT
8	defense response to Gram-negative bacterium	GO:050829	10.2	SERPINE1, LBP, IL6, CAMP
9	fibrinolysis	GO:042730	10.2	CPB2, KLKB1, PLG, PLAT, F2, GP1BA
10	positive regulation of positive chemotaxis	GO:050927	10.2	F3, F7, VEGFA
11	negative regulation of hormone secretion	GO:046888	10.1	EDN1, IL11, LIF
12	response to wounding	GO:009611	10.1	VWF, FN1, F2, CTSB, AGER
13	response to lipopolysaccharide	GO:032496	10.1	CXCL10, THPO, THBD, ELANE, EDN1, F3
14	blood coagulation, intrinsic pathway	GO:007597	10.0	A2M, KLKB1, F10, F2, F8, F9
15	acute-phase response	GO:006953	9.8	CRP, F2, F8, IL6, FN1, LBP
16	positive regulation of cell migration	GO:030335	9.8	VEGFA, F7, F3, F10, PDPN, EDN1
17	negative regulation of growth of symbiont in host	GO:044130	9.7	ELANE, TNF, CAMP, IL10, LBP
18	cell surface receptor signaling pathway	GO:007166	9.7	CXCL10, AGER, EDN1, F2, IFNA2, GP1BA
19	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	ELANE, EDN1, TNF, IL6, SERPINF2
20	defense response to Gram-positive bacterium	GO:050830	9.7	TNF, CAMP, IL6, LBP
21	positive regulation of cytokine secretion	GO:050715	9.6	TNF, IL10, MIF, CD14
22	negative regulation of lipid storage	GO:010888	9.6	CRP, TNF, IL6
23	response to mechanical stimulus	GO:009612	9.5	CXCL12, CTSB, TNF, F3
24	positive regulation of interleukin-6 production	GO:032755	9.5	TNF, IL6, IL1B, LBP
25	positive regulation of MAP kinase activity	GO:043406	9.4	VEGFA, TNF, EDN1, ELANE
26	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	HGF, IL6, IL11, MIF, LIF, VEGFA
27	response to heat	GO:009408	9.3	CPB2, SOD1, CXCL12, IL1B, CD14
28	proteolysis	GO:006508	9.3	KLKB1, ELANE, PROC, CPB2, ADAMTS13, HGF
29	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.3	TNF, IL6, IL11, MIF, LIF, VEGFA
30	negative regulation of apoptotic process	GO:043066	9.0	CXCL12, PROC, PF4, TNF, IL6, MIF
31	response to hypoxia	GO:001666	8.9	CXCL12, EDN1, PLAT, CRP, TNF, MB
32	response to glucocorticoid stimulus	GO:051384	8.7	OXT, TAT, PLAT, TNF, HMGB1, IL6
33	positive regulation of cell proliferation	GO:008284	8.7	CSF3, CXCL10, THPO, EDN1, F2, IL6
34	cell-cell signaling	GO:007267	8.6	CXCL10, TSPAN32, EDN1, IFNA2, IL1B, IL11
35	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	TAF1, TNF, HMGB1, IL6, IL1B, IL11
36	platelet degranulation	GO:002576	8.3	HGF, SOD1, A2M, PF4, PLG, PPBP
37	anti-apoptosis	GO:006916	7.8	HGF, SOD1, TNF, F3, F7, IL1B
38	inflammatory response	GO:006954	7.5	CXCL10, AGER, PDPN, CRP, TNF, IFNA2
39	platelet activation	GO:030168	7.3	THPO, A2M, PF4, PLG, PPBP, F13A1
40	blood coagulation	GO:007596	6.9	F3, F5, F7, F8, F9, IFNA2

Molecular functions related to disseminated intravascular coagulation according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase inhibitor activity	GO:004867	10.0	A2M, SERPINE1, SERPINF2, SERPINA5, SERPINC1, TFPI
2	protease binding	GO:002020	9.9	ELANE, TNF, F3, SERPINE1, SERPINF2, SERPINA5
3	cell surface binding	GO:043498	9.7	PLG, F3, MIF, LBP, VEGFA
4	heparin binding	GO:008201	9.5	ELANE, PF4, FN1, MPO, VEGFA, SERPIND1
5	serine-type endopeptidase activity	GO:004252	9.4	HGF, PROC, ELANE, KLKB1, KLK3, PLG
6	receptor binding	GO:005102	9.3	CXCL12, CXCL10, F2, F7, FGA, MIF
7	growth factor activity	GO:008083	7.6	PPBP, THPO, CXCL12, CSF3, HGF, F2
8	cytokine activity	GO:005125	6.8	VEGFA, CSF3, THPO, EDN1, TNF, HMGB1
9	protein binding	GO:005515	4.8	KLKB1, KLK3, PLG, PLAT, CRP, CTSB