DIC
MCID: DSS009
MIFTS: 59

Disseminated Intravascular Coagulation (DIC) malady

Immune, Blood categories

Summaries for Disseminated Intravascular Coagulation

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or... more...

MalaCards: Disseminated Intravascular Coagulation, also known as dissemin. intravascular coag., is related to sepsis and acute leukemia. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and Selected targets of C/EBPalpha. The drugs antithrombin iii, human and antithrombin iii,recombinant and the compounds ancrod and epsilon aminocaproic acid have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Disseminated Intravascular Coagulation

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune, Blood


Aliases & Descriptions:

disseminated intravascular coagulation 8 10 45 61
dissemin. intravascular coag. 8
defibrination syndrome 8
diffuse 8
dic 8


External Ids:

Disease Ontology8 DOID:11247
ICD9CM27 286.6
MeSH35 D004211
SNOMED-CT57 67406007, 267563002
NCIt40 C2992
ICD1025 D65

Related Diseases for Disseminated Intravascular Coagulation

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1628)
idRelated DiseaseScoreTop Affiliating Genes
1sepsis31.6ELANE, ADAMTS13, SERPINF2, SERPINC1, SERPINE1, THBD
2acute leukemia31.3THPO, FGA
3septic shock31.1ELANE, SERPINC1, SERPINE1, THBD, F3, FGA
4purpura fulminans31.1SERPINC1, PROC, F5
5acute promyelocytic leukemia31.0ELANE, THBD, F3
6meningococcemia31.0SERPINC1, THBD, F5
7thrombocytopenia30.9ADAMTS13, SERPINC1, THPO, THBD, F2, F3
8protein c deficiency30.9SERPINC1, SERPINE1, THBD, F2, PROC, F5
9acute pancreatitis30.7ELANE
10adenocarcinoma30.7TSPAN32, THBD, TAT, PF4, TNXA
11hemolytic-uremic syndrome30.6ADAMTS13, THBD
12hellp syndrome30.6ADAMTS13, SERPINC1, SERPINE1, F5
13hepatitis c30.6TSPAN32, THPO, F2, F9
14placental abruption30.6SERPINC1, F5
15antiphospholipid syndrome30.6ADAMTS13, SERPINC1, THBD, F2, F3, PF4
16systemic lupus erythematosus30.6ADAMTS13, THBD, F2, F3, FGA
17systemic scleroderma30.5THBD, FGA, PF4, PPBP
18coronary thrombosis30.5SERPINC1, SERPINE1, F3
19amyloidosis30.5F9
20adult respiratory distress syndrome30.5ELANE, THBD, F5
21protein s deficiency30.5SERPINC1, F5, F9
22acute myocardial infarction30.5ADAMTS13, SERPINF2, SERPINC1, SERPINE1, THBD, F3
23arthritis30.5TAT
24hepatitis a30.3F2
25polycythemia vera30.3THPO, THBD, PF4
26acquired immunodeficiency syndrome30.3TAT
27portal vein thrombosis30.3SERPINC1, THPO, F2, F5
28pregnancy loss30.3SERPINC1, F2, F3, F5
29stroke, ischemic30.3F2, F5
30vasculitis30.3ELANE, THBD, F2, TAT, FGA, PPBP
31kawasaki disease30.3ELANE
32thromboembolism30.3SERPINF2, SERPINC1, SERPINE1, THBD, F2, F3
33venous thrombosis30.3SERPINF2, SERPINC1, SERPINE1, THBD, F2, F3
34atherosclerosis30.2ELANE, SERPINF2, SERPINC1, SERPINE1, THBD, F3
35cadasil30.1ADAMTS13, SERPINF2, SERPINC1, SERPINE1, THBD, F2
36vascular disease30.1ELANE, SERPINC1, SERPINE1, THBD, F3, FGA
37asthma30.0ELANE, PPBP, CAMP
38stomach cancer30.0SERPINF2, FGA
39cystic fibrosis30.0ELANE, CAMP, F9
40coronary artery disease,29.9ADAMTS13, SERPINE1, THPO, THBD, F3, FGA
41uremia29.8PF4
42viral hepatitis29.8F2
43wegener's granulomatosis29.8ELANE
44acute liver failure29.8THPO, F2
45hemophilia b29.8F2, F3, F9
46deficiency anemia29.8ADAMTS13, THPO, F2, F3, TAT, PPBP
47hepatitis b29.7F2, TAT, F9
48patent foramen ovale29.6F5
49leukopenia29.6F2, F3
50colorectal cancer29.6PF4

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to disseminated intravascular coagulation

Clinical Features for Disseminated Intravascular Coagulation

Drugs & Therapeutics for Disseminated Intravascular Coagulation

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Disseminated Intravascular Coagulation

Drug clinical trials:

Search ClinicalTrials for Disseminated Intravascular Coagulation

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Search CenterWatch for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Genetic Tests for Disseminated Intravascular Coagulation

Anatomical Context for Disseminated Intravascular Coagulation

Animal Models for Disseminated Intravascular Coagulation or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.4F2, F3, FGA, F9
2MP:000539710.2ELANE, F9, PROC, PF4, FGA, F3
3MP:000538710.2F3, FGA, PROC, CAMP, F9, F2
4MP:000537610.1FGA, PF4, PROC, F5, F9, F3
5MP:001076810.0FGA, PROC, F5, CAMP, F9, F3
6MP:000537010.0F9, F5, PROC, FGA, THBD, SERPINE1

Publications for Disseminated Intravascular Coagulation

Sources:
51PubMed
See all sources

Articles related to Disseminated Intravascular Coagulation:

(show top 50)    (show all 743)
idTitleAuthorsYear
1
Disseminated intravascular coagulation does not play a major role in the pathogenesis of classical swine fever. (23107658)
2013
2
Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. (23361628)
2013
3
A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis. (24342495)
2013
4
Disseminated intravascular coagulation: a review for the internist. (23015284)
2013
5
Renal thrombotic microangiopathy in a patient with septic disseminated intravascular coagulation. (24279773)
2013
6
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. (23979365)
2013
7
Malignancies and disseminated intravascular coagulation. (23992020)
2013
8
Fatal multiple organ failure and disseminated intravascular coagulation in acute chromated copper arsenate poisoning. (23406319)
2013
9
Acute disseminated intravascular coagulation developed after dilation and curettage in an adenomyosis patient: a case report. (23867345)
2013
10
Successful treatment with recombinant thrombomodulin for B-cell lymphoma-associated hemophagocytic syndrome complicated by disseminated intravascular coagulation. (23696942)
2013
11
Current concepts in the management of disseminated intravascular coagulation. (22682134)
2012
12
Diagnostic criteria and laboratory tests for disseminated intravascular coagulation. (23216594)
2012
13
Therapeutic interventions in endotoxin-induced disseminated intravascular coagulation. (22690065)
2012
14
Recombinant human soluble thrombomodulin safely and effectively rescues acute promyelocytic leukemia patients from disseminated intravascular coagulation. (22917769)
2012
15
Successful treatment of sepsis-induced disseminated intravascular coagulation in a patient with idiopathic thrombocytopenic purpura using recombinant human soluble thrombomodulin. (21240494)
2011
16
A case of disseminated intravascular coagulation associated with a prosthetic heart valve. (21191264)
2011
17
Implications of donor disseminated intravascular coagulation on kidney allograft recipients. (21372214)
2011
18
Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy. (21676072)
2011
19
Disseminated intravascular coagulation in a case of brucellosis. (20682596)
2011
20
Disseminated intravascular coagulation during resection of a meningioma: case report. (21242833)
2011
21
A novel management method for disseminated intravascular coagulation like syndrome after a sting of Hemiscorpius lepturus: a case series. (22433880)
2011
22
Post varicella disseminated intravascular coagulation and transient protein S deficiency in an otherwise healthy 6-year-old boy: a case report. (20844918)
2010
23
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. (19062078)
2009
24
Death by clot: acute coronary syndromes, ischemic stroke, pulmonary embolism, and disseminated intravascular coagulation. (19411875)
2009
25
Prognostic value of platelet indices as determined by ADVIA 120 in patients suspected of having disseminated intravascular coagulation. (18333843)
2008
26
Disseminated intravascular coagulation: current concepts. (18716745)
2008
27
Serum thrombomodulin level relates to the clinical course of disseminated intravascular coagulation, multiorgan dysfunction syndrome, and mortality in patients with sepsis. (18431261)
2008
28
Expression profiling and disseminated intravascular coagulation: finding genes gone wild. (17915353)
2007
29
Severe disseminated intravascular coagulation caused by congestive heart failure and left ventricular thrombus. (17496682)
2007
30
Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide-induced disseminated intravascular coagulation in rats. (16810104)
2006
31
Disseminated intravascular coagulation following selective termination in a twin pregnancy. A case report. (16491008)
2006
32
Does disseminated intravascular coagulation lead to multiple organ failure? (15992668)
2005
33
Disseminated intravascular coagulation in an ambulatory young woman. (16131459)
2005
34
Evaluation of early detection and management of disseminated intravascular coagulation among Alexandria University pediatric intensive care patients. (15537719)
2004
35
Update on the treatment of disseminated intravascular coagulation. (15203862)
2004
36
Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation. (14518675)
2003
37
Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. (11740383)
2001
38
Disseminated intravascular coagulation and stroke associated with cervical cancer. (17895187)
1999
39
Dissecting aortic aneurysm complicated with acute disseminated intravascular coagulation: case report. (10418224)
1999
40
Treatment options for clinically recognized disseminated intravascular coagulation. (9515780)
1998
41
The antithrombotic effects of recombinant human soluble thrombomodulin (rhsTM) on tissue factor-induced disseminated intravascular coagulation in crab-eating monkeys (Macaca fascicularis). (9282791)
1997
42
Pig I alpha I appears unmodified in plasma in case of endotoxin-induced disseminated intravascular coagulation. (9523017)
1997
43
Purpura fulminans induced by disseminated intravascular coagulation following infection in 2 unrelated children with double heterozygosity for factor V Leiden and protein S deficiency. (9241737)
1997
44
Plasma tissue factor pathway inhibitor in disseminated intravascular coagulation: comparison of its behavior with plasma tissue factor. (8585047)
1995
45
Disseminated intravascular coagulation after liver resection: retrospective study in patients with biliary tract carcinoma. (7740431)
1995
46
Plasma interleukin-6 in patients with disseminated intravascular coagulation]. (1479690)
1992
47
Disseminated intravascular coagulation in Korean hemorrhagic fever. (6141786)
1983
48
Dissecting aortic aneurysm and disseminated intravascular coagulation. (831972)
1977
49
Viral pneumonia in pregnancy: report of a case complicated by disseminated intravascular coagulation and acute renal failure. (4416868)
1974
50
Disseminated intravascular coagulation after excision of giant hemangioma. (4545017)
1974

Genetic Variations for Disseminated Intravascular Coagulation

Expression for genes affiliated with Disseminated Intravascular Coagulation

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for genes affiliated with Disseminated Intravascular Coagulation

Sources:
54Reactome, 12EMD Millipore, 50PharmGKB, 52QIAGEN, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SERPINF2, SERPINE1
210.4ELANE, SERPINC1, F9
310.4THBD, F2, PROC
4
Hide members
10.4THPO, F2, FGA
510.4F9, PROC, F2
6
Hide members
10.4F2, F3, PROC, F9
7
Hide members
10.3SERPINC1, THBD, F2, F3, FGA, PROC
8
Hide members
10.3F9, PPBP, F5, PROC, PF4
9
Hide members
10.3PPBP, F5, PF4, FGA, SERPINE1, SERPINF2
10
Hide members
10.3FGA, F3, F2, THBD, THPO, SERPINE1
11
Hide members
10.2F9, F5, PROC, FGA, F3, F2
12
Hide members
10.2F3, FGA, PROC, F5, F9, F2
13
Hide members
10.2SERPINF2, SERPINC1, SERPINE1, THBD, F2, F3

Compounds for genes affiliated with Disseminated Intravascular Coagulation

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1ancrod4510.8F5, FGA, F2, THBD, SERPINE1, SERPINC1
2epsilon aminocaproic acid4510.7F9, F3, F2, SERPINE1, SERPINC1, SERPINF2
3kininogen4510.7SERPINF2, F9, F5, F3, F2, SERPINE1
4fibrinopeptide a4510.7PF4, FGA, F2, THBD, SERPINC1, SERPINF2
5serine4510.7F9, CAMP, FGA, TAT, ADAMTS13
6ptca4510.7FGA, THBD, SERPINF2, PF4, PPIC, PPBP
7danaparoid4510.7TNXA, F5, PF4, F3, SERPINC1, F2
8argatroban45 1111.7TNXA, F5, FGA, F3, F2, THBD
9bivalirudin45 1111.7SERPINC1, THBD, TNXA, F5, FGA, F3
10hirugen4510.7FGA, F2, SERPINC1, F5, THBD
11ximelagatran45 1111.7THBD, F5, SERPINC1, F2, F3
12warfarin45 50 11 2413.7FGA, SERPINC1, PF4, PROC, F9, PPIC
13fondaparinux4510.7F9, TNXA, F5, PF4, F3, F2
14heparinoids4510.7F3, F2, SERPINC1, F5, THBD
15protamine sulfate4510.7F3, F5, PF4, TAT, F2, SERPINC1
16ristocetin4510.7SERPINF2, ADAMTS13, SERPINC1, F2, F9, PPBP
17dermatan sulfate4510.7F9, TNXA, F5, PF4, F3, F2
18protamine4510.7TNXA, F5, PF4, FGA, F3, F2
1911-dehydrothromboxane b24510.6PF4, FGA, F2, THBD, SERPINE1, PPBP
20endotoxin4510.6F9, CAMP, TNXA, F5, FGA, F3
21desmopressin45 60 29 1113.6F9, PPBP, F5, F3, F2, THBD
22gamma-carboxyglutamic acid4510.6F9, TNXA, F5, PROC, PF4, F3
23ticlopidine45 1111.6PF4, FGA, SERPINC1, ADAMTS13, PPBP, F3
24iloprost45 60 29 1113.6F3, SERPINC1, CAMP, THBD, PPBP, PF4
25coumarin45 2 50 2413.6F9, SERPINC1, F2, F3, FGA, F5
26Drotrecogin alfa1110.6F2, PF4, SERPINE1, THBD, F5
27citrate4510.6PPBP, PF4, SERPINC1, THBD, ELANE, F5
28aprotinin45 1111.6PPBP, F5, PF4, FGA, F3, THBD
29pge14510.6FGA, SERPINE1, F2, F5, PF4, CAMP
30tranexamic acid45 1111.6SERPINC1, SERPINE1, F2, F3, F9
31heparin45 29 11 2413.6TAT, THPO, ADAMTS13, ELANE, FGA, PF4
32hirudin4510.5F9, TNXA, F5, PF4, FGA, F3
33prostacyclin4510.5ELANE, SERPINC1, SERPINE1, THPO, CAMP, PF4
34aspirin45 50 29 2413.5ELANE, SERPINC1, SERPINE1, PPBP, F5, PF4
35epinephrine45 11 2412.5SERPINF2, THPO, F2, F3, ELANE, PPBP
36polysaccharide4510.5F5, PF4, F3, THPO, SERPINC1, THBD
37dipyridamole45 60 29 1113.5PPBP, SERPINE1, PF4, FGA, F3, F2
38creatinine4510.5F2, F9, TNXA, PPBP, F5, PF4
39phospholipid4510.5F5, TNXA, PROC, CAMP, F3, THBD
40txb24510.5FGA, THBD, PPBP, PF4, SERPINF2, F3
41alanine4510.4F3, F2, THBD, THPO, SERPINC1, PPBP
42adp45 29 2412.4SERPINF2, PF4, PPBP, PROC, FGA
43homocysteine45 2411.4F2, F3, F5, F9, SERPINC1, THBD
44inogatran4510.4F2, SERPINC1, F3, F5
45vegf4510.4PPBP, CAMP, F3, F5, PF4, THBD
466-ketoprostaglandin f1alpha4510.4SERPINF2, FGA, PF4, PPBP, THBD
47benzamidine45 1111.4F5, F9, SERPINC1, THBD, ELANE
48fibrinogen4510.3F9, ADAMTS13, ELANE, PPIC, TNXA, SERPINF2
49cacl24510.2THBD, F9, F5, FGA, F3
50dextran sulfate4510.1F5, F9, ELANE

GO Terms for genes affiliated with Disseminated Intravascular Coagulation

Sources:
16Gene Ontology
See all sources

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.4F2, PROC, F9
2platelet alpha granule lumenGO:03109310.4SERPINF2, PPBP, F5, PF4, FGA, SERPINE1
3extracellular spaceGO:00561510.2PPBP, F5, PF4, FGA, F3, F2
4cell surfaceGO:00998610.2FGA, F3, THBD, SERPINF2, TSPAN32, ADAMTS13
5fibrinogen complexGO:00557710.1SERPINF2, FGA
6extracellular regionGO:00557610.1PROC, F5, PPBP, CAMP, F9, PF4

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.6F2, THBD, SERPINE1, SERPINF2
2peptidyl-glutamic acid carboxylationGO:01718710.6F2, PROC, F9
3negative regulation of blood coagulationGO:03019510.6SERPINE1, THBD, PROC
4fibrinolysisGO:04273010.6F2, SERPINE1, SERPINF2
5negative regulation of plasminogen activationGO:01075710.5SERPINE1, SERPINF2
6platelet degranulationGO:00257610.5PPBP, F5, PF4, FGA, SERPINE1, SERPINF2
7leukocyte migrationGO:05090010.5ELANE, THBD, F2, PROC
8blood coagulation, extrinsic pathwayGO:00759810.5F3, F9
9platelet activationGO:03016810.4PPBP, F5, PF4, FGA, F2, THPO
10positive regulation of blood coagulationGO:03019410.4SERPINE1, F2
11negative regulation of endopeptidase activityGO:01095110.4SERPINF2, SERPINC1, SERPINE1
12blood coagulationGO:00759610.4SERPINF2, F9, PPBP, F5, PROC, PF4
13proteolysisGO:00650810.2F9, PROC, F2, ADAMTS13, ELANE
14negative regulation of platelet activationGO:01054410.1THBD, F2

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.4SERPINF2, SERPINC1, SERPINE1
2protease bindingGO:00202010.2ELANE, SERPINF2, SERPINC1, SERPINE1, F3
3serine-type endopeptidase activityGO:00425210.1F9, PROC, F2, ELANE

Products for genes affiliated with Disseminated Intravascular Coagulation

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Disseminated Intravascular Coagulation

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet