MCID: DSS009
MIFTS: 56

Disseminated Intravascular Coagulation

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Disseminated Intravascular Coagulation

MalaCards integrated aliases for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 12 36 28 51 41 14 69 59
Diffuse or Disseminated Intravascular Coagulation 12
Defibrination Syndrome 12
Dic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11247
ICD10 32 D65
ICD9CM 34 286.6
MeSH 41 D004211
NCIt 46 C2992
SNOMED-CT 64 267563002 67406007
KEGG 36 H01587
UMLS 69 C0012739

Summaries for Disseminated Intravascular Coagulation

PubMed Health : 59
About disseminated intravascular coagulation: Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is a condition in which blood clots form throughout the body's small blood vessels. These blood clots can reduce or block blood flow through the blood vessels, which can damage the body's organs.In DIC, the increased clotting uses up platelets (PLATE-lets) and clotting factors in the blood. Platelets are blood cell fragments that stick together to seal small cuts and breaks on blood vessel walls and stop bleeding. Clotting factors are proteins needed for normal blood clotting.With fewer platelets and clotting factors in the blood, serious bleeding can occur. DIC can cause internal and external bleeding.Internal bleeding occurs inside the body. External bleeding occurs underneath or from the skin or mucosa. (The mucosa is the tissue that lines some organs and body cavities, such as your nose and mouth.)DIC can cause life-threatening bleeding.

MalaCards based summary : Disseminated Intravascular Coagulation, also known as diffuse or disseminated intravascular coagulation, is related to purpura fulminans and protein c deficiency. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Tranexamic Acid and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Wikipedia : 72 Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the... more...

Related Diseases for Disseminated Intravascular Coagulation

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 384)
# Related Disease Score Top Affiliating Genes
1 purpura fulminans 32.9 F2 F3 SERPINC1 SERPINF2
2 protein c deficiency 31.9 F2 F5 F9 SERPINC1 THBD
3 thrombotic thrombocytopenic purpura 30.8 ADAMTS13 F3 THBD
4 hemorrhagic fever 30.7 F2 F3 SERPINC1
5 thrombocytopenia 30.7 ADAMTS13 F3 THBD
6 meningococcemia 30.7 F5 SERPINC1 SERPINE1 THBD
7 purpura 30.6 ADAMTS13 F2 F3 SERPINC1 THBD
8 osteonecrosis 30.6 F2 SERPINC1 SERPINE1
9 endocarditis 30.5 F2 PIK3C2A SERPINC1
10 placental abruption 30.5 F2 F5 SERPINC1 THBD
11 protein s deficiency 30.5 F2 F3 F5 SERPINC1
12 heparin-induced thrombocytopenia 30.5 F3 SERPINC1
13 acute promyelocytic leukemia 30.3 ELANE F3 SERPINF2 THBD
14 liver cirrhosis 30.2 F2 SERPINC1 SERPINF2
15 antithrombin iii deficiency 30.2 F2 F5 SERPINC1
16 shwartzman phenomenon 30.2 F3 SERPINE1 THBD
17 portal vein thrombosis 30.2 F2 F5 SERPINC1 SERPINE1
18 pulmonary edema 30.1 F2 PIK3C2A SERPINC1
19 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 30.1 MB PIK3C2A
20 compartment syndrome 30.1 F2 MB PIK3C2A
21 hemophilia 30.0 F2 F3 F9
22 esophageal varix 29.9 F2 SERPINC1
23 catastrophic antiphospholipid syndrome 29.8 ADAMTS13 F3 F5 SERPINE1
24 coronary thrombosis 29.8 F3 PLAT SERPINC1 SERPINE1
25 cardiac tamponade 29.8 F2 F9
26 systemic lupus erythematosus 29.7 ADAMTS13 ELANE F2 F3 THBD
27 factor xiii deficiency 29.6 F3 F5 SERPINE1 SERPINF2
28 hemophilia b 29.6 F2 F3 F9 SERPINC1
29 factor x deficiency 29.5 F2 F3 F5 F9 SERPINC1
30 thrombosis 29.3 F2 F3 F5 F9 PLAT SERPINC1
31 antiphospholipid syndrome 29.3 ADAMTS13 F2 F3 F5 PLAT SERPINC1
32 thrombophilia due to thrombin defect 29.2 F2 F3 F5 PLAT SERPINC1 SERPINE1
33 blue toe syndrome 29.1 F2 F3 PLG SERPINC1 SERPINE1
34 giant hemangioma 29.0 F2 F3 PLG SERPINC1 SERPINF2
35 korean hemorrhagic fever 29.0 F2 F3 PLG SERPINC1 SERPINF2
36 marantic endocarditis 29.0 F2 F3 PLAT SERPINC1 SERPINF2 THBD
37 hellp syndrome 28.9 ADAMTS13 F2 F3 F5 PLAT SERPINC1
38 pulmonary embolism 28.5 F2 F3 F5 F9 PLAT SERPINC1
39 stroke, ischemic 27.8 F2 F3 F5 FGA PLAT PLG
40 acute myocardial infarction 27.5 F3 MB PIK3C2A PLAT PLG SERPINC1
41 hemorrhagic disease 27.3 ADAMTS13 F2 F3 F5 F9 PLAT
42 myocardial infarction 25.9 ADAMTS13 F2 F3 F5 FGA MB
43 dic in newborn 11.7
44 acute monoblastic leukemia 11.5
45 kidney cortex necrosis 11.2
46 intracranial sinus thrombosis 10.5 F3 SERPINC1
47 leukemia 10.5
48 blood protein disease 10.5 F2 SERPINC1
49 paracetamol poisoning 10.5 F2 F5
50 von willebrand disease, type 1 10.5 F2 F3

Comorbidity relations with Disseminated Intravascular Coagulation via Phenotypic Disease Network (PDN): (show all 15)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Cardiac Arrest
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Mitral Valve Disease
Prostate Cancer Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to Disseminated Intravascular Coagulation

Symptoms & Phenotypes for Disseminated Intravascular Coagulation

GenomeRNAi Phenotypes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 PIK3C2A SERPINC1 SERPINE1 SERPINF2 THBD

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 F5 PIK3C2A ADAMTS13 ELANE F9 F2
2 cardiovascular system MP:0005385 10.26 F5 F9 F2 FGA F3 MB
3 hematopoietic system MP:0005397 10.25 ADAMTS13 ELANE F9 F2 FGA F3
4 immune system MP:0005387 10.15 ADAMTS13 ELANE F9 F2 FGA F3
5 embryo MP:0005380 10.11 MB F5 F9 F2 FGA F3
6 mortality/aging MP:0010768 10 F5 ADAMTS13 ELANE F9 F2 FGA
7 integument MP:0010771 9.92 F5 F2 FGA F3 SERPINE1 PLAT
8 liver/biliary system MP:0005370 9.8 F5 F9 FGA SERPINC1 SERPINE1 THBD
9 nervous system MP:0003631 9.61 F3 F5 F2 FGA SERPINC1 PIK3C2A
10 respiratory system MP:0005388 9.17 MB F2 F3 SERPINE1 PLAT THBD

Drugs & Therapeutics for Disseminated Intravascular Coagulation

PubMedHealth treatment related to Disseminated Intravascular Coagulation: 59

Treatment for disseminated intravascular coagulation (DIC) depends on its severity and cause. The main goals of treating DIC are to control bleeding and clotting problems and treat the underlying cause.

Drugs for Disseminated Intravascular Coagulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4 1197-18-8 5526
2
Thrombin Approved, Investigational Phase 4
3
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
4 Calcium, Dietary Phase 4,Phase 3
5 Prasugrel hydrochloride Phase 4 389574-19-0
6 Thromboplastin Phase 4
7 Coagulants Phase 4
8 Hemostatics Phase 4
9 Peripheral Nervous System Agents Phase 4
10 Antifibrinolytic Agents Phase 4
11 Platelet Aggregation Inhibitors Phase 4
12 Factor VIII Phase 4
13 Liver Extracts Phase 4
14 Analgesics Phase 4
15 calcium channel blockers Phase 4
16 Central Nervous System Depressants Phase 4
17 Tocolytic Agents Phase 4
18 Anesthetics Phase 4
19 Anti-Arrhythmia Agents Phase 4
20 Anticonvulsants Phase 4
21
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
22 calcium heparin Phase 3
23
protease inhibitors Phase 2, Phase 3
24 Fibrinolytic Agents Phase 3
25 Serine Proteinase Inhibitors Phase 2, Phase 3
26 Trypsin Inhibitors Phase 2, Phase 3
27 Urinastatin Phase 2, Phase 3
28 HIV Protease Inhibitors Phase 2, Phase 3
29 Anticoagulants Phase 3,Phase 2
30 Pharmaceutical Solutions Phase 3,Phase 2
31 Antithrombin III Phase 3,Phase 2
32 Antithrombins Phase 3,Phase 2
33 serine Nutraceutical Phase 2, Phase 3
34
Epinephrine Approved, Vet_approved 51-43-4 5816
35
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
36 Racepinephrine Approved 329-65-7
37
Substance P Investigational 33507-63-0 44359816
38 Plasminogen
39 Plasminogen Activator Inhibitor 1
40 Plasminogen Inactivators
41 Calcitonin Gene-Related Peptide
42 calcitonin
43 neurokinin A
44
Hydrogen sulfide 7783-06-4 402
45 Respiratory System Agents
46 Adrenergic Agents
47 Adrenergic Agonists
48 Adrenergic alpha-Agonists
49 Mydriatics
50 Adrenergic beta-Agonists

Interventional clinical trials:

(show all 30)

# Name Status NCT ID Phase Drugs
1 Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment Completed NCT01704001 Phase 4 ART-123
2 A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor Completed NCT01800435 Phase 4 aPCC, aPCC + TXA;rFVIIa, rFVIIa + TXA
3 The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation Completed NCT01099566 Phase 4 Prasugrel;Placebo
4 The Efficacy of Xuebijing Injection on Sepsis Recruiting NCT03238742 Phase 4 Xuebijing Injection;0.9% normal saline
5 Prevention of Postpartum Hemorrhage With TXA Not yet recruiting NCT03326596 Phase 4 Tranexamic Acid 1000 mg/10ml normal saline infusion
6 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
7 Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation Unknown status NCT02654561 Phase 3 Heparin Sodium;Saline
8 The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia Unknown status NCT01865266 Phase 2, Phase 3 Ulinaststin for injection;placebo
9 An Open-label Study of KW-3357 Completed NCT01384903 Phase 3 KW-3357;Plasma-derived antithrombin
10 A Clinical Study of KW-3357 in Patients With DIC Completed NCT01384396 Phase 3 KW-3357
11 Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis Completed NCT02135770 Phase 3 Unfractionated heparin
12 A Phase 3 Clinical Study of KW-3357 in Patients With DIC Terminated NCT01384409 Phase 3 KW-3357
13 Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation Completed NCT00487656 Phase 2 ART-123;placebo
14 Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis Terminated NCT00506519 Phase 2 antithrombin alfa (INN name)
15 4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock Unknown status NCT01211899
16 Hypercoagulation Screening in Cancer Unknown status NCT02622815
17 Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock Unknown status NCT02062970
18 Coagulation Factor Changes Associated With Postpartum Hysterectomies Completed NCT00456547
19 Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1- Completed NCT02862366
20 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Completed NCT03135496
21 TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL. Completed NCT02135627 TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery.
22 Study of New Biological Markers for Prediction of Severe Acute Pancreatitis Completed NCT00786591
23 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
24 The Procalcitonin and Survival Study Completed NCT00271752
25 Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa Recruiting NCT03266432
26 Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery Recruiting NCT03064152
27 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
28 sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia Recruiting NCT03441711
29 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555
30 Thrombin Generation and Thromboelastography in Non-overt DIC Terminated NCT00299949

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: disseminated intravascular coagulation

Genetic Tests for Disseminated Intravascular Coagulation

Genetic tests related to Disseminated Intravascular Coagulation:

# Genetic test Affiliating Genes
1 Disseminated Intravascular Coagulation 28

Anatomical Context for Disseminated Intravascular Coagulation

MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

38
Skin, Liver, Bone, Endothelial, Neutrophil, Prostate, Testes

Publications for Disseminated Intravascular Coagulation

Articles related to Disseminated Intravascular Coagulation:

(show top 50) (show all 918)
# Title Authors Year
1
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
2
Antithrombin concentrate use in disseminated intravascular coagulation of sepsis: meta-analyses revisited. ( 29316235 )
2018
3
How I treat disseminated intravascular coagulation. ( 29255070 )
2018
4
Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan. ( 29202320 )
2018
5
Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: re-evaluation of a 'pendulum effect' drug using a nationwide database. ( 29316251 )
2018
6
The disseminated intravascular coagulation score is a novel predictor for portal vein thrombosis in cirrhotic patients with hepatitis B. ( 29178991 )
2018
7
Management of disseminated intravascular coagulation: current insights on antithrombin and thrombomodulin treatments. ( 29343993 )
2018
8
Successful management of obstetric disseminated intravascular coagulation using a portable fibrinogen-measuring device. ( 29359377 )
2018
9
Bilateral orbital compartment syndrome in a patient with disseminated intravascular coagulation. ( 29308942 )
2018
10
Impact of non-anticoagulant therapy on patients with sepsis-induced disseminated intravascular coagulation: A multicenter, case-control study. ( 29329022 )
2018
11
Population pharmacokinetics of thrombomodulin alfa in pediatric patients with hematological malignancy and disseminated intravascular coagulation. ( 27734584 )
2017
12
Lazarus Syndrome With Crizotinib in a Non-Small Cell Lung Cancer Patient With ROS1 Rearrangement and Disseminated Intravascular Coagulation. ( 28844392 )
2017
13
Reply to the editor- Disseminated intravascular coagulation as a cause of shock related to device extraction. ( 29180120 )
2017
14
Understanding and treating solid tumor-related disseminated intravascular coagulation in the "era" of targeted cancer therapies. ( 29318012 )
2017
15
Successful anticoagulant therapy for disseminated intravascular coagulation during conservative management of placenta percreta: a case report and literature review. ( 29284430 )
2017
16
Blood Components Load in Post-operative Neurosurgical Patients Suspected with Disseminated Intravascular Coagulation. ( 28824246 )
2017
17
Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion. ( 28505615 )
2017
18
Circulating syndecan-1 predicts the development of disseminated intravascular coagulation in patients with sepsis. ( 28843664 )
2017
19
Erratum: Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ( 27834077 )
2017
20
Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation. ( 28011507 )
2017
21
Disseminated Intravascular Coagulation on Admission Predicts Complications and Poor Prognosis of Acute Pancreatitis: Analysis of the Nationwide Epidemiological Survey in Japan. ( 28085757 )
2017
22
Atractylenolide a8 protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect. ( 28756923 )
2017
23
Disseminated<i>Mycobacterium avium</i>-Intracellulare Complex Infection Presenting With Disseminated Intravascular Coagulation in an AIDS Patient. ( 29164156 )
2017
24
Thrombotic Thrombocytopenic Purpura or Disseminated Intravascular Coagulation? ( 28904488 )
2017
25
TAFRO Syndrome with Disseminated Intravascular Coagulation Successfully Treated with Tocilizumab and Recombinant Thrombomodulin. ( 29279488 )
2017
26
Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model. ( 28744465 )
2017
27
Disseminated Intravascular Coagulation (DIC) ( 28722864 )
2017
28
Prognostic significance of disseminated intravascular coagulation in patients with heat stroke in a nationwide registry. ( 29253838 )
2017
29
Septic miscarriage with toxic shock syndrome and disseminated intravascular coagulation (DIC): The role of surgery, recombinant activated factor VII and intravenous immunoglobulin (IVIG). ( 29308782 )
2017
30
Aortic Aneurysm-associated Disseminated Intravascular Coagulation (DIC) that Responded Well to a Switch from Warfarin to Rivaroxaban. ( 28943552 )
2017
31
Disseminated carcinomatosis of the bone marrow with disseminated intravascular coagulation as the first symptom of recurrent rectal cancer successfully treated with chemotherapy: A case report and review of the literature. ( 28599429 )
2017
32
Primary Hepatic Angiosarcoma Mimicking Multifocal Liver Abscess with Disseminated Intravascular Coagulation and Hemoperitoneum. ( 28680781 )
2017
33
Recent advances in pathophysiology of disseminated intravascular coagulation: the role of circulating histones and neutrophil extracellular traps. ( 29399324 )
2017
34
Fatal acute disseminated intravascular coagulation as presentation of advanced ALK-positive non-small cell lung cancer: Does oncogene addiction matter? ( 29353684 )
2017
35
Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease. ( 28552727 )
2017
36
Recurrent Early Coronary Stent Thrombosis under Chronic Disseminated Intravascular Coagulation. ( 29162782 )
2017
37
Dramatic response of acute disseminated intravascular coagulation to erlotinib in a patient with lung adenocarcinoma with activating EGFR mutation. ( 28730909 )
2017
38
Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury. ( 28826407 )
2017
39
To the Editor- Disseminated intravascular coagulation as a cause of shock related to device extraction. ( 29180121 )
2017
40
Disseminated intravascular coagulation syndrome two months after conservative management of placenta accreta. About two patients. ( 28689576 )
2017
41
Effect of Thrombomodulin Alfa on Disseminated Intravascular Coagulation in Patients with Lung Cancer. ( 28717074 )
2017
42
Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study. ( 28831134 )
2017
43
Acute exacerbation of chronic disseminated intravascular coagulation associated with thoracoabdominal aortic aneurysm after tooth extraction. ( 28766813 )
2017
44
A Proposal of the Modification of Japanese Society on Thrombosis and Hemostasis (JSTH) Disseminated Intravascular Coagulation (DIC) Diagnostic Criteria for Sepsis-Associated DIC. ( 28747069 )
2017
45
Postoperative disseminated intravascular coagulation in a pregnant patient with Blue Rubber Bleb Nevus Syndrome presenting with acute intestinal obstruction: Case report and literature review. ( 28858742 )
2017
46
Chronic disseminated intravascular coagulation induced by left atrial thrombus in a patient with giant "normal" heart: A case report. ( 28002328 )
2016
47
Successful treatments with polymyxin B hemoperfusion and recombinant human thrombomodulin for fulminant Clostridium difficile-associated colitis with septic shock and disseminated intravascular coagulation: a case report. ( 27468959 )
2016
48
Recombinant human soluble thrombomodulin and mortality in sepsis-induced disseminated intravascular coagulation. A multicentre retrospective study. ( 26939575 )
2016
49
Diffuse Cutaneous Bullous Mastocytosis and Disseminated Intravascular Coagulation Postvaccination: A Case Report. ( 27436822 )
2016
50
The thromboelastometric discrepancy between septic and trauma induced disseminated intravascular coagulation diagnosed by the scoring system from the Japanese association for acute medicine. ( 27495106 )
2016

Variations for Disseminated Intravascular Coagulation

Expression for Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for Disseminated Intravascular Coagulation

Pathways related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 F2 F3 F5 F9 FGA PLAT
2
Show member pathways
12.59 F2 F3 F5 F9 FGA SERPINC1
3
Show member pathways
12.09 F2 PLAT PLG SERPINE1
4 11.84 F2 F3 F5 F9 FGA PLAT
5 11.77 F3 PLG SERPINE1
6 11.65 F3 SERPINE1 THBD
7
Show member pathways
11.57 F2 F3 F5 F9 FGA PLAT
8 11.39 PLAT PLG SERPINE1
9 11.27 FGA PLAT PLG
10 11.23 ELANE PLAT PLG
11 10.9 PLAT PLG
12 10.85 F2 PLG
13 10.67 F2 F9
14 10.67 PLAT PLG SERPINE1 SERPINF2

GO Terms for Disseminated Intravascular Coagulation

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.86 ADAMTS13 ELANE F3 FGA PLAT PLG
2 endoplasmic reticulum lumen GO:0005788 9.85 ADAMTS13 F2 F5 F9 FGA SERPINC1
3 blood microparticle GO:0072562 9.8 F2 FGA PLG SERPINC1 SERPINF2
4 extracellular region GO:0005576 9.73 ADAMTS13 ELANE F2 F3 F5 F9
5 platelet alpha granule lumen GO:0031093 9.55 F5 FGA PLG SERPINE1 SERPINF2
6 platelet alpha granule GO:0031091 9.46 F5 FGA
7 extracellular space GO:0005615 9.44 ADAMTS13 ELANE F2 F3 F5 F9
8 fibrinogen complex GO:0005577 9.43 FGA SERPINF2
9 extracellular exosome GO:0070062 10.1 ELANE F2 F3 F9 FGA MB

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.91 ADAMTS13 ELANE F2 F9 PLAT PLG
2 negative regulation of endopeptidase activity GO:0010951 9.77 SERPINC1 SERPINE1 SERPINF2
3 cellular protein metabolic process GO:0044267 9.77 F2 F5 FGA PLG SERPINC1
4 negative regulation of peptidase activity GO:0010466 9.76 SERPINC1 SERPINE1 SERPINF2
5 platelet activation GO:0030168 9.74 ADAMTS13 F2 FGA
6 platelet degranulation GO:0002576 9.72 F5 FGA PLG SERPINE1 SERPINF2
7 negative regulation of fibrinolysis GO:0051918 9.65 F2 PLG SERPINE1 SERPINF2 THBD
8 blood coagulation GO:0007596 9.65 ADAMTS13 F2 F3 F5 F9 FGA
9 fibrinolysis GO:0042730 9.63 F2 FGA PLAT PLG SERPINE1 SERPINF2
10 negative regulation of proteolysis GO:0045861 9.62 F2 PLAT
11 positive regulation of collagen biosynthetic process GO:0032967 9.61 F2 SERPINF2
12 regulation of blood coagulation GO:0030193 9.61 F2 SERPINC1
13 signal peptide processing GO:0006465 9.6 F2 F9
14 blood coagulation, intrinsic pathway GO:0007597 9.58 F2 F9
15 negative regulation of blood coagulation GO:0030195 9.56 SERPINE1 THBD
16 positive regulation of blood coagulation GO:0030194 9.55 F2 SERPINE1
17 peptidyl-glutamic acid carboxylation GO:0017187 9.54 F2 F9
18 plasminogen activation GO:0031639 9.52 FGA PLAT
19 negative regulation of platelet activation GO:0010544 9.51 F2 THBD
20 acute inflammatory response to antigenic stimulus GO:0002438 9.49 ELANE SERPINC1
21 negative regulation of plasminogen activation GO:0010757 9.48 SERPINE1 SERPINF2
22 blood coagulation, extrinsic pathway GO:0007598 9.46 F3 F9
23 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.4 ELANE F2
24 hemostasis GO:0007599 9.28 ADAMTS13 F2 F3 F5 F9 FGA

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.73 ADAMTS13 ELANE F2 F9 PLAT PLG
2 receptor binding GO:0005102 9.72 F2 FGA PLAT PLG SERPINE1
3 peptidase inhibitor activity GO:0030414 9.61 SERPINC1 SERPINE1 SERPINF2
4 serine-type endopeptidase inhibitor activity GO:0004867 9.58 SERPINC1 SERPINE1 SERPINF2
5 serine-type peptidase activity GO:0008236 9.55 ELANE F2 F9 PLAT PLG
6 endopeptidase activity GO:0004175 9.54 ELANE F9 PLG
7 serine-type endopeptidase activity GO:0004252 9.43 ELANE F2 F3 F9 PLAT PLG
8 protease binding GO:0002020 9.02 ELANE F3 SERPINC1 SERPINE1 SERPINF2

Sources for Disseminated Intravascular Coagulation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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