DIC
MCID: DSS009
MIFTS: 66

Disseminated Intravascular Coagulation (DIC) malady

Immune diseases, Blood diseases categories

Summaries for Disseminated Intravascular Coagulation

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63Wikipedia, 32MalaCards
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Wikipedia:63 Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or... more...

MalaCards: Disseminated Intravascular Coagulation, also known as dissemin. intravascular coag., is related to leukemia and acute leukemia. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Dissolution of Fibrin Clot and Selected targets of C/EBPalpha. The drugs antithrombin iii, human and antithrombin iii,recombinant and the compounds ancrod and epsilon aminocaproic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Aliases & Classifications for Disseminated Intravascular Coagulation

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

disseminated intravascular coagulation 8 10 44 60
dissemin. intravascular coag. 8
defibrination syndrome 8
diffuse 8
dic 8


External Ids:

Disease Ontology8 DOID:11247
ICD9CM27 286.6
MeSH34 D004211
SNOMED-CT56 67406007, 267563002
NCIt39 C2992
ICD1025 D65

Related Diseases for Disseminated Intravascular Coagulation

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17GeneCards, 18GeneDecks
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Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1580)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.3SERPINF2, THPO, FGA, PF4, PPBP, F9
2acute leukemia31.3THPO, FGA
3purpura31.2ADAMTS13, SERPINC1, THPO
4liver cirrhosis30.9ADAMTS13, SERPINF2, SERPINC1, THPO, F2, F3
5hepatitis30.9THPO, F2, TAT
6thrombocytopenia30.9ADAMTS13, SERPINC1, THPO, THBD, F2, F3
7glomerulonephritis30.9ELANE
8pancreatitis30.8ELANE
9peritonitis30.8F2
10pneumonia30.8ELANE, FGA
11protein s deficiency30.8SERPINC1, F5, F9
12pulmonary embolism30.8SERPINF2, SERPINC1, F2, F3, FGA, PF4
13acute pancreatitis30.7ELANE
14malaria30.7ADAMTS13, TSPAN32, TAT
15lupus erythematosus30.7SERPINC1, THBD, F2, F3, F5
16adenocarcinoma30.7TSPAN32, THBD, TAT, PF4, TNXA
17hemolytic-uremic syndrome30.6ADAMTS13, THBD
18hellp syndrome30.6ADAMTS13, SERPINC1, SERPINE1, F5
19placental abruption30.6SERPINC1, F5
20protein c deficiency30.6SERPINC1, SERPINE1, THBD, F2, PROC, F5
21antiphospholipid syndrome30.6ADAMTS13, SERPINC1, THBD, F2, F3, PF4
22systemic lupus erythematosus30.6ADAMTS13, THBD, F2, F3, FGA
23myocardial infarction30.6ADAMTS13, SERPINF2, SERPINC1, SERPINE1, F3, TAT
24systemic scleroderma30.5THBD, FGA, PF4, PPBP
25hepatitis a30.5F2
26coronary thrombosis30.5SERPINC1, SERPINE1, F3
27purpura fulminans30.5SERPINC1, PROC, F5
28antithrombin iii deficiency30.5SERPINC1, F2, F5
29amyloidosis30.5F9
30ischemia30.5ADAMTS13, TAT, FGA, PF4
31factor x deficiency30.5F2, F3, F5, F9
32hypertension30.5SERPINE1, F2, F5, PPBP
33diabetes mellitus30.5SERPINC1, SERPINE1, THBD, FGA, PF4
34adult respiratory distress syndrome30.5ELANE, THBD, F5
35acute myocardial infarction30.5ADAMTS13, SERPINF2, SERPINC1, SERPINE1, THBD, F3
36breast cancer30.5TSPAN32, SERPINE1, THPO, PPBP, CAMP, F9
37arthritis30.4TAT
38rheumatoid arthritis30.4ELANE, TSPAN32, THPO, PF4, PPBP
39sarcoma30.3THPO, TAT
40herpes simplex30.3TAT, CAMP, F9
41dementia30.3TAT
42hepatitis b30.2F2, TAT, F9
43polycythemia30.2THPO, PPBP
44schistosomiasis30.2TSPAN32, SERPINF2, PPBP
45polycythemia vera30.2THPO, THBD, PF4
46acquired immunodeficiency syndrome30.2TAT
47factor v deficiency30.2F2, F3, F5
48myeloma30.2TSPAN32, PF4
49portal vein thrombosis30.2SERPINC1, THPO, F2, F5
50vitamin k deficiency hemorrhagic disease30.2F2, F3

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to disseminated intravascular coagulation

Clinical Features for Disseminated Intravascular Coagulation

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Drugs & Therapeutics for Disseminated Intravascular Coagulation

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Disseminated Intravascular Coagulation

Drug clinical trials:

Search ClinicalTrials for Disseminated Intravascular Coagulation

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Search CenterWatch for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Disseminated Intravascular Coagulation

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Anatomical Context for Disseminated Intravascular Coagulation

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32MalaCards
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MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

32
Kidney, Skin, Liver, Prostate, Testes, Bone, Bone marrow, Endothelial, Brain, Heart, Thyroid, Monocytes, T cells, Lung, B cells, Breast, Colon, Spleen, Placenta, Myeloid, Whole blood, Tongue

Animal Models for Disseminated Intravascular Coagulation or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.4F2, F3, FGA, F9
2MP:000539710.2ELANE, F9, PROC, PF4, FGA, F3
3MP:000538710.2F3, FGA, PROC, CAMP, F9, F2
4MP:000537610.1FGA, PF4, PROC, F5, F9, F3
5MP:001076810.0FGA, PROC, F5, CAMP, F9, F3
6MP:000537010.0F9, F5, PROC, FGA, THBD, SERPINE1

Publications for Disseminated Intravascular Coagulation

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50PubMed
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Articles related to Disseminated Intravascular Coagulation:

(show top 50)    (show all 743)
idTitleAuthorsYear
1
Cardiovascular collapse and disseminated intravascular coagulation as complications of ethanol embolization of arteriovenous malformations in the upper lip: case report and literature review. (24139295)
2014
2
Docetaxel was effective in the management of metastatic angiosarcoma associated with disseminated intravascular coagulation syndrome. (23557403)
2014
3
Use of antithrombin and thrombomodulin in the management of disseminated intravascular coagulation in patients with acute cholangitis. (23710320)
2013
4
Serum des-R prothrombin activation peptide fragment 2: a novel prognostic marker for disseminated intravascular coagulation. (23664563)
2013
5
Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis. (24103584)
2013
6
A prospective analysis of disseminated intravascular coagulation in patients with infections. (23994978)
2013
7
Higher prognostic value of soluble fibrin complexes than D-dimer and fibrin degradation product for disseminated intravascular coagulation in patients with liver cirrhosis. (23314386)
2013
8
Low ADAMTS-13 activity during hemorrhagic events with disseminated intravascular coagulation. (23494361)
2013
9
Recurrent disseminated intravascular coagulation caused by intermittent dosing of rifampin. (22302861)
2012
10
Successful surgical resection of infected left atrial myxoma in a case complicated with disseminated intravascular coagulation and multiple cerebral infarctions: case report. (21569401)
2011
11
Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury--analysis of 242 cases. (21355766)
2011
12
Multiple organ infarctions following disseminated intravascular coagulation precipitated by sepsis in a healthy infant: a case report. (21186015)
2010
13
Disseminated intravascular coagulation with acutely-thrombosed popliteal aneurysm. (23555403)
2010
14
Fatal Klebsiella pneumoniae meningitis and concomitant disseminated intravascular coagulation in a patient with diabetes mellitus. (19561976)
2009
15
Development of multiple cerebral infarcts from disseminated intravascular coagulation after chemoembolization of a large hepatocellular carcinoma. (19328718)
2009
16
Dapsone hypersensitivity syndrome causing disseminated intravascular coagulation. (21829418)
2009
17
Correlation between plasma activity of ADAMTS-13 and coagulopathy, and prognosis in disseminated intravascular coagulation. (19162307)
2009
18
Diagnosis and treatment of disseminated intravascular coagulation: a case report. (17604485)
2007
19
Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. (17890943)
2007
20
Thrombin generation by exposure of blood to endotoxin: a simple model to study disseminated intravascular coagulation. (16708116)
2006
21
Disseminated intravascular coagulation in cats. (17186846)
2006
22
Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. (16856920)
2006
23
Quinine-induced renal failure as a result of rhabdomyolysis, haemolytic uraemic syndrome and disseminated intravascular coagulation. (16780456)
2006
24
Disseminated intravascular coagulation at presentation of advanced gastric cancer. (17214103)
2006
25
Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation. (16244764)
2005
26
Disseminated intravascular coagulation: a rare entity in burn injury. (15774294)
2005
27
Toll-like receptors on platelets: the key for disseminated intravascular coagulation in sepsis? (15792687)
2005
28
Techniques: Intravital microscopy--a method for investigating disseminated intravascular coagulation? (15925708)
2005
29
Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. (15599145)
2004
30
Disseminated intravascular coagulation and coagulation disorders. (17021539)
2004
31
Diagnosis of disseminated intravascular coagulation in sepsis scoring system of a thrombosis-hemostasis center. (15673932)
2004
32
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
33
Adult-onset Still's disease with respiratory distress syndrome, polyserositis and disseminated intravascular coagulation: a case with a fatal outcome. (12673909)
2003
34
Postabortal haemorrhage and disseminated intravascular coagulation due to placenta accreta. (14504880)
2003
35
Coagulation inhibitors in sepsis and disseminated intravascular coagulation. (11193281)
2000
36
Disseminated intravascular coagulation and purpura fulminans secondary to infection. (10942620)
2000
37
Disseminated intravascular coagulation: clinical and laboratory aspects. (9723580)
1998
38
Changes of factor XIII a and b subunit in patients with disseminated intravascular coagulation syndrome]. (8847818)
1996
39
Dermatan sulphate for the treatment of disseminated intravascular coagulation (DIC) in acute leukemia: a randomised, heparin-controlled pilot study. (8029809)
1994
40
Heparin, low molecular weight heparin, heparinoid, and antithrombin III therapy of disseminated intravascular coagulation]. (7679453)
1993
41
The detection of preventive hypofibronectinemia in diagnosing the development of disseminated intravascular coagulation in patients with myocardial infarction at the hospital rehabilitation stage]. (8303587)
1993
42
Principles of the therapy for disseminated intravascular coagulation: current status and new trends]. (7679452)
1993
43
Disseminated intravascular coagulation in lupus erythematosus with acute liver damage. (1300175)
1992
44
Plasma protein S in disseminated intravascular coagulation, liver disease, collagen disease, diabetes mellitus, and under oral anticoagulant therapy. (2528431)
1989
45
Fatal disseminated intravascular coagulation secondary to streptococcal cervicitis. (3066659)
1988
46
Bone marrow necrosis associated with tumor emboli and disseminated intravascular coagulation. (6639254)
1983
47
Disseminated intravascular coagulation in patients with meningococcal infection: laboratory diagnosis and prognostic factors. (715382)
1978
48
Acute fatty liver of pregnancy with disseminated intravascular coagulation. (636858)
1978
49
Acute disseminated intravascular coagulation as the presenting and predominant clinical manifestation in a patient with a mucinous adenocarcinoma. (4376755)
1974
50
Disseminated intravascular coagulation in miliary tuberculosis. (5055697)
1972

Genetic Variations for Disseminated Intravascular Coagulation

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Expression for genes affiliated with Disseminated Intravascular Coagulation

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for genes affiliated with Disseminated Intravascular Coagulation

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Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4SERPINF2, SERPINE1
210.4ELANE, SERPINC1, F9
310.4THBD, F2, PROC
4
Hide members
10.4THPO, F2, FGA
510.4F9, PROC, F2
6
Hide members
10.4F2, F3, PROC, F9
7
Hide members
10.3SERPINC1, THBD, F2, F3, FGA, PROC
8
Hide members
10.3F9, PPBP, F5, PROC, PF4
9
Hide members
10.3PPBP, F5, PF4, FGA, SERPINE1, SERPINF2
10
Hide members
10.3FGA, F3, F2, THBD, THPO, SERPINE1
11
Hide members
10.2F9, F5, PROC, FGA, F3, F2
12
Hide members
10.2F3, FGA, PROC, F5, F9, F2
13
Hide members
10.2SERPINF2, SERPINC1, SERPINE1, THBD, F2, F3

Compounds for genes affiliated with Disseminated Intravascular Coagulation

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show top 50)    (show all 197)
idCompoundScoreTop Affiliating Genes
1ancrod4410.8F5, FGA, F2, THBD, SERPINE1, SERPINC1
2epsilon aminocaproic acid4410.7F9, F3, F2, SERPINE1, SERPINC1, SERPINF2
3kininogen4410.7SERPINF2, F9, F5, F3, F2, SERPINE1
4fibrinopeptide a4410.7PF4, FGA, F2, THBD, SERPINC1, SERPINF2
5serine4410.7F9, CAMP, FGA, TAT, ADAMTS13
6ptca4410.7FGA, THBD, SERPINF2, PF4, PPIC, PPBP
7danaparoid4410.7TNXA, F5, PF4, F3, SERPINC1, F2
8argatroban44 1111.7TNXA, F5, FGA, F3, F2, THBD
9bivalirudin44 1111.7SERPINC1, THBD, TNXA, F5, FGA, F3
10hirugen4410.7FGA, F2, SERPINC1, F5, THBD
11ximelagatran44 1111.7THBD, F5, SERPINC1, F2, F3
12warfarin44 49 11 2413.7FGA, SERPINC1, PF4, PROC, F9, PPIC
13fondaparinux4410.7F9, TNXA, F5, PF4, F3, F2
14heparinoids4410.7F3, F2, SERPINC1, F5, THBD
15protamine sulfate4410.7F3, F5, PF4, TAT, F2, SERPINC1
16ristocetin4410.7SERPINF2, ADAMTS13, SERPINC1, F2, F9, PPBP
17dermatan sulfate4410.7F9, TNXA, F5, PF4, F3, F2
18protamine4410.7TNXA, F5, PF4, FGA, F3, F2
1911-dehydrothromboxane b24410.6PF4, FGA, F2, THBD, SERPINE1, PPBP
20endotoxin4410.6F9, CAMP, TNXA, F5, FGA, F3
21desmopressin44 59 28 1113.6F9, PPBP, F5, F3, F2, THBD
22gamma-carboxyglutamic acid4410.6F9, TNXA, F5, PROC, PF4, F3
23ticlopidine44 1111.6PF4, FGA, SERPINC1, ADAMTS13, PPBP, F3
24iloprost44 59 28 1113.6F3, SERPINC1, CAMP, THBD, PPBP, PF4
25coumarin44 2 49 2413.6F9, SERPINC1, F2, F3, FGA, F5
26Drotrecogin alfa1110.6F2, PF4, SERPINE1, THBD, F5
27citrate4410.6PPBP, PF4, SERPINC1, THBD, ELANE, F5
28aprotinin44 1111.6PPBP, F5, PF4, FGA, F3, THBD
29pge14410.6FGA, SERPINE1, F2, F5, PF4, CAMP
30tranexamic acid44 1111.6SERPINC1, SERPINE1, F2, F3, F9
31heparin44 28 11 2413.6TAT, THPO, ADAMTS13, ELANE, FGA, PF4
32hirudin4410.5F9, TNXA, F5, PF4, FGA, F3
33prostacyclin4410.5ELANE, SERPINC1, SERPINE1, THPO, CAMP, PF4
34aspirin44 49 28 2413.5ELANE, SERPINC1, SERPINE1, PPBP, F5, PF4
35epinephrine44 11 2412.5SERPINF2, THPO, F2, F3, ELANE, PPBP
36polysaccharide4410.5F5, PF4, F3, THPO, SERPINC1, THBD
37dipyridamole44 59 28 1113.5PPBP, SERPINE1, PF4, FGA, F3, F2
38creatinine4410.5F2, F9, TNXA, PPBP, F5, PF4
39phospholipid4410.5F5, TNXA, PROC, CAMP, F3, THBD
40txb24410.5FGA, THBD, PPBP, PF4, SERPINF2, F3
41alanine4410.4F3, F2, THBD, THPO, SERPINC1, PPBP
42adp44 28 2412.4SERPINF2, PF4, PPBP, PROC, FGA
43homocysteine44 2411.4F2, F3, F5, F9, SERPINC1, THBD
44inogatran4410.4F2, SERPINC1, F3, F5
45vegf4410.4PPBP, CAMP, F3, F5, PF4, THBD
466-ketoprostaglandin f1alpha4410.4SERPINF2, FGA, PF4, PPBP, THBD
47benzamidine44 1111.4F5, F9, SERPINC1, THBD, ELANE
48fibrinogen4410.3F9, ADAMTS13, ELANE, PPIC, TNXA, SERPINF2
49cacl24410.2THBD, F9, F5, FGA, F3
50dextran sulfate4410.1F5, F9, ELANE

GO Terms for genes affiliated with Disseminated Intravascular Coagulation

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16Gene Ontology
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Cellular components related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.4F2, PROC, F9
2platelet alpha granule lumenGO:03109310.4SERPINF2, PPBP, F5, PF4, FGA, SERPINE1
3extracellular spaceGO:00561510.2PPBP, F5, PF4, FGA, F3, F2
4cell surfaceGO:00998610.2FGA, F3, THBD, SERPINF2, TSPAN32, ADAMTS13
5fibrinogen complexGO:00557710.1SERPINF2, FGA
6extracellular regionGO:00557610.1PROC, F5, PPBP, CAMP, F9, PF4

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.6F2, THBD, SERPINE1, SERPINF2
2peptidyl-glutamic acid carboxylationGO:01718710.6F2, PROC, F9
3negative regulation of blood coagulationGO:03019510.6SERPINE1, THBD, PROC
4fibrinolysisGO:04273010.6F2, SERPINE1, SERPINF2
5negative regulation of plasminogen activationGO:01075710.5SERPINE1, SERPINF2
6platelet degranulationGO:00257610.5PPBP, F5, PF4, FGA, SERPINE1, SERPINF2
7leukocyte migrationGO:05090010.5ELANE, THBD, F2, PROC
8blood coagulation, extrinsic pathwayGO:00759810.5F3, F9
9platelet activationGO:03016810.4PPBP, F5, PF4, FGA, F2, THPO
10positive regulation of blood coagulationGO:03019410.4SERPINE1, F2
11negative regulation of endopeptidase activityGO:01095110.4SERPINF2, SERPINC1, SERPINE1
12blood coagulationGO:00759610.4SERPINF2, F9, PPBP, F5, PROC, PF4
13proteolysisGO:00650810.2F9, PROC, F2, ADAMTS13, ELANE
14negative regulation of platelet activationGO:01054410.1THBD, F2

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.4SERPINF2, SERPINC1, SERPINE1
2protease bindingGO:00202010.2ELANE, SERPINF2, SERPINC1, SERPINE1, F3
3serine-type endopeptidase activityGO:00425210.1F9, PROC, F2, ELANE

Products for genes affiliated with Disseminated Intravascular Coagulation

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Disseminated Intravascular Coagulation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet