MCID: DSS009
MIFTS: 50

Disseminated Intravascular Coagulation

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Disseminated Intravascular Coagulation

MalaCards integrated aliases for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 12 29 52 42 14 69
Diffuse or Disseminated Intravascular Coagulation 12
Defibrination Syndrome 12
Dic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11247
ICD10 33 D65
ICD9CM 35 286.6
MeSH 42 D004211
NCIt 47 C2992
SNOMED-CT 64 267563002 67406007
UMLS 69 C0012739

Summaries for Disseminated Intravascular Coagulation

MalaCards based summary : Disseminated Intravascular Coagulation, also known as diffuse or disseminated intravascular coagulation, is related to hemolytic-uremic syndrome and congenital syphilis. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Thrombin and Tranexamic Acid have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and prostate, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Wikipedia : 72 Disseminated intravascular coagulation (DIC) is a pathological process characterized by the widespread... more...

Related Diseases for Disseminated Intravascular Coagulation

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
id Related Disease Score Top Affiliating Genes
1 hemolytic-uremic syndrome 30.8 F2 F3 SERPINC1
2 congenital syphilis 30.1 F2 F3 F5 SERPINC1
3 factor x deficiency 30.1 F2 F3 F9
4 priapism 30.0 F5 SERPINC1 SERPINE1 THBD
5 myocardial infarction 24.4 ADAMTS13 F2 F3 F5 FGA MB
6 purpura fulminans 11.8
7 dic in newborn 11.5
8 protein c deficiency 11.4
9 acute monoblastic leukemia 11.4
10 kidney cortex necrosis 11.1
11 sagittal sinus thrombosis 10.8 F3 SERPINC1
12 hereditary amyloidosis 10.8 F3 SERPINC1
13 variably protease-sensitive prionopathy 10.8 F2 F5
14 von willibrand disease, type 3 10.8 F2 F3
15 coronary sinus stenosis 10.7 F5 SERPINE1
16 amelogenesis imperfecta hypomaturation type 10.7 F5 SERPINE1
17 bile duct cystadenoma 10.7 F2 F5
18 female breast cancer 10.7 F2 F3
19 sporotrichosis 10.7 F2 F3
20 mesomelia 10.7 PLAT THBD
21 pilomyxoid astrocytoma 10.6 F2 SERPINC1
22 immunodeficiency 32b, monocyte and dendritic cell deficiency, autosomal recessive 10.6 PLAT THBD
23 fragile x syndrome type 2 10.6 F2 F3 SERPINC1
24 chronic inflammatory demyelinating polyneuritis 10.6 F2 F3
25 spinal cord lipoma 10.6 F2 F3 SERPINC1
26 syncope 10.6 F2 F5 SERPINC1
27 central retinal artery occlusion 10.6 F2 F3 SERPINC1
28 superior limbic keratoconjunctivitis 10.6 F2 F5 SERPINC1
29 hepadnavirus infection 10.6 F2 F3 SERPINC1
30 follicular adenoma 10.6 F2 F5 SERPINC1
31 hiv-1 10.6 F2 F5 SERPINC1
32 glutathioninuria 10.6 F2 F5 SERPINC1
33 angular blepharoconjunctivitis 10.6 F2 F5 SERPINC1
34 conjunctival disease 10.6 PLAT SERPINC1
35 46,xy ovotesticular disorder of sex development 10.6 F2 F3 F5
36 granulomatous hepatitis 10.6 F2 F3 SERPINC1
37 stoll alembik finck syndrome 10.6 F5 SERPINC1 SERPINE1
38 porphyria 10.6 F2 MB
39 necrotic uveal melanoma 10.6 F3 F5 SERPINC1
40 craniopharyngioma 10.6 F3 SERPINE1 THBD
41 joint disorders 10.6 F2 F5 SERPINC1
42 cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorinural hearing loss 10.6 PLAT SERPINE1
43 moderately severe hemophilia b 10.5 F2 F3 F5
44 thrombomodulin anomalies, familial 10.5 F2 F3 F5
45 ischemic heart disease 10.5 F2 SERPINC1 SERPINE1
46 cerebral cavernous malformations 3 10.5 PLAT SERPINC1
47 lockwood feingold syndrome 10.5 F2 F5 SERPINE1
48 primary pigmented nodular adrenocortical disease 10.5 F2 F5
49 adrenal carcinoma 10.5 F2 PIK3C2A
50 hidradenoma 10.5 F2 F3 SERPINE1

Comorbidity relations with Disseminated Intravascular Coagulation via Phenotypic Disease Network (PDN): (show all 15)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Cardiac Arrest Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Left Ventricular Outflow Tract Obstruction Mitral Valve Disease
Prostate Cancer Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to Disseminated Intravascular Coagulation

Symptoms & Phenotypes for Disseminated Intravascular Coagulation

GenomeRNAi Phenotypes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 PIK3C2A SERPINC1 SERPINE1 SERPINF2 THBD

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ADAMTS13 ELANE F2 F3 F5 F9
2 cardiovascular system MP:0005385 10.26 F2 F3 F5 F9 FGA MB
3 hematopoietic system MP:0005397 10.25 F2 F3 F9 FGA MB PIK3C2A
4 immune system MP:0005387 10.15 F2 F3 F9 FGA PIK3C2A PLAT
5 embryo MP:0005380 10.11 F2 F3 F5 F9 FGA MB
6 mortality/aging MP:0010768 10 FGA MB PIK3C2A PLAT PLG SERPINC1
7 integument MP:0010771 9.87 F2 F3 F5 FGA PLG SERPINE1
8 liver/biliary system MP:0005370 9.8 FGA PLG SERPINC1 SERPINE1 THBD F5
9 nervous system MP:0003631 9.61 F2 F3 F5 FGA PIK3C2A PLAT
10 respiratory system MP:0005388 9.17 F2 F3 MB PLAT PLG SERPINE1

Drugs & Therapeutics for Disseminated Intravascular Coagulation

Drugs for Disseminated Intravascular Coagulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved Phase 4
2
Tranexamic Acid Approved Phase 4 1197-18-8 5526
3
Magnesium Sulfate Approved, Vet_approved Phase 4 7487-88-9 24083
4 Calcium, Dietary Phase 4,Phase 3
5 Coagulants Phase 4
6 Hemostatics Phase 4
7 Liver Extracts Phase 4
8 Platelet Aggregation Inhibitors Phase 4
9 Prasugrel hydrochloride Phase 4 389574-19-0
10 Thromboplastin Phase 4
11 Antifibrinolytic Agents Phase 4
12 Factor VIII Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Analgesics Phase 4
15 Anesthetics Phase 4
16 Anti-Arrhythmia Agents Phase 4
17 Anticonvulsants Phase 4
18 calcium channel blockers Phase 4
19 Central Nervous System Depressants Phase 4
20 Tocolytic Agents Phase 4
21
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
22 Anticoagulants Phase 3,Phase 2
23 calcium heparin Phase 3
24 Fibrinolytic Agents Phase 3
25 Pharmaceutical Solutions Phase 3,Phase 2
26 HIV Protease Inhibitors Phase 2, Phase 3
27
protease inhibitors Phase 2, Phase 3
28 Serine Proteinase Inhibitors Phase 2, Phase 3
29 Trypsin Inhibitors Phase 2, Phase 3
30 Urinastatin Phase 2, Phase 3
31 Antithrombin III Phase 3,Phase 2
32 Antithrombins Phase 3,Phase 2
33 serine Nutraceutical Phase 2, Phase 3
34 Natriuretic Agents Phase 1
35 Natriuretic Peptide, Brain Phase 1
36
Epinephrine Approved, Vet_approved 51-43-4 5816
37 Racepinephrine Approved
38
Substance P Investigational 33507-63-0 44359816
39 Plasminogen
40 Plasminogen Activator Inhibitor 1
41 Plasminogen Inactivators
42
Hydrogen sulfide 7783-06-4 402
43 neurokinin A
44 Adrenergic Agents
45 Adrenergic Agonists
46 Adrenergic alpha-Agonists
47 Adrenergic beta-Agonists
48 Anti-Asthmatic Agents
49 Autonomic Agents
50 Bronchodilator Agents

Interventional clinical trials:

(show all 30)

id Name Status NCT ID Phase Drugs
1 Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment Completed NCT01704001 Phase 4 ART-123
2 The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation Completed NCT01099566 Phase 4 Prasugrel;Placebo
3 A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor Completed NCT01800435 Phase 4 aPCC, aPCC + TXA;rFVIIa, rFVIIa + TXA
4 The Efficacy of Xuebijing Injection on Sepsis Recruiting NCT03238742 Phase 4 Xuebijing Injection;0.9% normal saline
5 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
6 Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation Unknown status NCT02654561 Phase 3 Heparin Sodium;Saline
7 The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia Unknown status NCT01865266 Phase 2, Phase 3 Ulinaststin for injection;placebo
8 An Open-label Study of KW-3357 Completed NCT01384903 Phase 3 KW-3357;Plasma-derived antithrombin
9 A Clinical Study of KW-3357 in Patients With DIC Completed NCT01384396 Phase 3 KW-3357
10 Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis Completed NCT02135770 Phase 3 Unfractionated heparin
11 A Phase 3 Clinical Study of KW-3357 in Patients With DIC Terminated NCT01384409 Phase 3 KW-3357
12 Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation Completed NCT00487656 Phase 2 ART-123;placebo
13 Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis Terminated NCT00506519 Phase 2 antithrombin alfa (INN name)
14 Study to Look at the Effects of ART-123 on Patients With Sepsis and Disseminated Intravascular Coagulation (DIC) Withdrawn NCT01090115 Phase 2 ART-123;placebo
15 A Comparison of B Type Natriuretic Peptide Levels and Hemodynamics Using the Nexfin Device in Healthy Pregnant and Preeclamptic Women - A Pilot Study Unknown status NCT02527018 Phase 1
16 4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock Unknown status NCT01211899
17 Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock Unknown status NCT02062970
18 Coagulation Factor Changes Associated With Postpartum Hysterectomies Completed NCT00456547
19 Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1- Completed NCT02862366
20 Study of New Biological Markers for Prediction of Severe Acute Pancreatitis Completed NCT00786591
21 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Completed NCT03135496
22 TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL. Completed NCT02135627 TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery.
23 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
24 The Procalcitonin and Survival Study Completed NCT00271752
25 Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa Recruiting NCT03266432
26 Hypercoagulation Screening in Cancer Recruiting NCT02622815
27 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
28 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555
29 Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery Not yet recruiting NCT03064152
30 Thrombin Generation and Thromboelastography in Non-overt DIC Terminated NCT00299949

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: disseminated intravascular coagulation

Genetic Tests for Disseminated Intravascular Coagulation

Genetic tests related to Disseminated Intravascular Coagulation:

id Genetic test Affiliating Genes
1 Disseminated Intravascular Coagulation 29

Anatomical Context for Disseminated Intravascular Coagulation

MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

39
Liver, Endothelial, Prostate, Neutrophil, Bone, Testes, Brain

Publications for Disseminated Intravascular Coagulation

Articles related to Disseminated Intravascular Coagulation:

(show top 50) (show all 897)
id Title Authors Year
1
Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury. ( 28826407 )
2017
2
Disseminated carcinomatosis of the bone marrow with disseminated intravascular coagulation as the first symptom of recurrent rectal cancer successfully treated with chemotherapy: A case report and review of the literature. ( 28599429 )
2017
3
Primary Hepatic Angiosarcoma Mimicking Multifocal Liver Abscess with Disseminated Intravascular Coagulation and Hemoperitoneum. ( 28680781 )
2017
4
Disseminated Intravascular Coagulation on Admission Predicts Complications and Poor Prognosis of Acute Pancreatitis: Analysis of the Nationwide Epidemiological Survey in Japan. ( 28085757 )
2017
5
Aortic Aneurysm-associated Disseminated Intravascular Coagulation (DIC) that Responded Well to a Switch from Warfarin to Rivaroxaban. ( 28943552 )
2017
6
Effect of Thrombomodulin Alfa on Disseminated Intravascular Coagulation in Patients with Lung Cancer. ( 28717074 )
2017
7
Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease. ( 28552727 )
2017
8
Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model. ( 28744465 )
2017
9
Population pharmacokinetics of thrombomodulin alfa in pediatric patients with hematological malignancy and disseminated intravascular coagulation. ( 27734584 )
2017
10
Lazarus Syndrome With Crizotinib in a Non-Small Cell Lung Cancer Patient With ROS1 Rearrangement and Disseminated Intravascular Coagulation. ( 28844392 )
2017
11
Circulating syndecan-1 predicts the development of disseminated intravascular coagulation in patients with sepsis. ( 28843664 )
2017
12
A Proposal of the Modification of Japanese Society on Thrombosis and Hemostasis (JSTH) Disseminated Intravascular Coagulation (DIC) Diagnostic Criteria for Sepsis-Associated DIC. ( 28747069 )
2017
13
Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation. ( 28011507 )
2017
14
Evaluation of the new Chinese Disseminated Intravascular Coagulation Scoring System in critically ill patients: A multicenter prospective study. ( 28831134 )
2017
15
Atractylenolide a8 protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect. ( 28756923 )
2017
16
Acute exacerbation of chronic disseminated intravascular coagulation associated with thoracoabdominal aortic aneurysm after tooth extraction. ( 28766813 )
2017
17
Blood Components Load in Post-operative Neurosurgical Patients Suspected with Disseminated Intravascular Coagulation. ( 28824246 )
2017
18
Disseminated intravascular coagulation syndrome two months after conservative management of placenta accreta. About two patients. ( 28689576 )
2017
19
Erratum: Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ( 27834077 )
2017
20
Dramatic response of acute disseminated intravascular coagulation to erlotinib in a patient with lung adenocarcinoma with activating EGFR mutation. ( 28730909 )
2017
21
Thrombotic Thrombocytopenic Purpura or Disseminated Intravascular Coagulation? ( 28904488 )
2017
22
Disseminated Intravascular Coagulation (DIC) ( 28722864 )
2017
23
Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion. ( 28505615 )
2017
24
Postoperative disseminated intravascular coagulation in a pregnant patient with Blue Rubber Bleb Nevus Syndrome presenting with acute intestinal obstruction: Case report and literature review. ( 28858742 )
2017
25
Disseminated intravascular coagulation at diagnosis is a strong predictor for both arterial and venous thrombosis in newly diagnosed acute myeloid leukemia. ( 27354723 )
2016
26
Disseminated Intravascular Coagulation. ( 28013226 )
2016
27
Danazol-induced peliosis hepatis accompanied by disseminated intravascular coagulation in a patient with myelodysplastic syndrome transformed from aplastic anemia. ( 27599419 )
2016
28
OC-10 - Disseminated intravascular coagulation at diagnosis strongly predicts both arterial and venous thrombosis in acute myeloid leukemia patients. ( 27161682 )
2016
29
Recombinant human soluble thrombomodulin and mortality in sepsis-induced disseminated intravascular coagulation. A multicentre retrospective study. ( 26939575 )
2016
30
Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ( 27578502 )
2016
31
Management of cancer-associated disseminated intravascular coagulation. ( 27067981 )
2016
32
Antithrombin supplementation and risk of bleeding in patients with sepsis-associated disseminated intravascular coagulation. ( 27479532 )
2016
33
Antithrombin Supplementation and Mortality in Sepsis-Induced Disseminated Intravascular Coagulation: A Multicenter Retrospective Observational Study. ( 27548460 )
2016
34
Evidence of NETosis in Septic Shock-induced Disseminated Intravascular Coagulation. ( 27488091 )
2016
35
Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity. ( 27629997 )
2016
36
Neutrophil Fluorescence: A New Indicator of Cell Activation During Septic Shock-Induced Disseminated Intravascular Coagulation. ( 27441905 )
2016
37
Comparison of Two Diagnostic Scores of Disseminated Intravascular Coagulation in Pregnant Women Admitted to the ICU. ( 27861597 )
2016
38
The impact of disseminated intravascular coagulation on the outcome of cancer patients with venous thromboembolism: Erratum. ( 27380477 )
2016
39
Disseminated Intravascular Coagulation in Secondary Glioblastoma due to Excessive Intraoperative Bleeding: Case Report and Review of the Literature. ( 26921703 )
2016
40
Factor XII-mediated contact activation related to poor prognosis in disseminated intravascular coagulation. ( 26706311 )
2016
41
Comparison of Procedure-Based and Diagnosis-Based Identifications of Severe Sepsis and Disseminated Intravascular Coagulation in Administrative Data. ( 27064132 )
2016
42
Intramural hematoma of the colon caused by double-balloon enteroscopy in a patient with chronic disseminated intravascular coagulation. ( 27008555 )
2016
43
Disseminated Intravascular Coagulation Syndromes in Obstetrics. ( 26901325 )
2016
44
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. ( 27274647 )
2016
45
Shock, acute disseminated intravascular coagulation, and microvascular thrombosis: is 'shock liver' the unrecognized provocateur of ischemic limb necrosis: reply. ( 27608440 )
2016
46
Spontaneous intracranial hypotension complicated by malignancyinduced disseminated intravascular coagulation: A case report. ( 27854087 )
2016
47
Disseminated intravascular coagulation in paediatrics. ( 27540263 )
2016
48
Fatal Hemorrhage from Kidney after Endovascular Repair for Chronic Type B Dissection Complicated with Disseminated Intravascular Coagulation. ( 28018508 )
2016
49
Helicobacter pylori Eradication Therapy for Thrombocytopenia after Surgery for Abdominal Aortic Aneurysm with Disseminated Intravascular Coagulation. ( 28018509 )
2016
50
The thromboelastometric discrepancy between septic and trauma induced disseminated intravascular coagulation diagnosed by the scoring system from the Japanese association for acute medicine. ( 27495106 )
2016

Variations for Disseminated Intravascular Coagulation

Expression for Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for Disseminated Intravascular Coagulation

Pathways related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 F2 F3 F5 F9 FGA PLAT
2
Show member pathways
12.59 F2 F3 F5 F9 FGA SERPINC1
3 11.84 F2 F3 F5 F9 FGA PLAT
4 11.71 F3 PLG SERPINE1
5 11.63 F3 SERPINE1 THBD
6
Show member pathways
11.57 F2 F3 F5 F9 FGA PLAT
7 11.39 PLAT PLG SERPINE1
8 11.27 FGA PLAT PLG
9 11.23 ELANE PLAT PLG
10 10.94 PLAT PLG
11 10.83 F2 PLG
12 10.67 PLAT PLG SERPINE1 SERPINF2
13 10.65 F2 F9

GO Terms for Disseminated Intravascular Coagulation

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.86 ADAMTS13 ELANE F3 FGA PLAT PLG
2 endoplasmic reticulum lumen GO:0005788 9.85 ADAMTS13 F2 F5 F9 FGA SERPINC1
3 blood microparticle GO:0072562 9.8 F2 FGA PLG SERPINC1 SERPINF2
4 extracellular region GO:0005576 9.73 ADAMTS13 ELANE F2 F3 F5 F9
5 platelet alpha granule lumen GO:0031093 9.55 F5 FGA PLG SERPINE1 SERPINF2
6 platelet alpha granule GO:0031091 9.46 F5 FGA
7 extracellular space GO:0005615 9.44 ADAMTS13 ELANE F2 F3 F5 F9
8 fibrinogen complex GO:0005577 9.43 FGA SERPINF2
9 extracellular exosome GO:0070062 10.1 ELANE F2 F3 F9 FGA MB

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.91 ADAMTS13 ELANE F2 F9 PLAT PLG
2 negative regulation of endopeptidase activity GO:0010951 9.77 SERPINC1 SERPINE1 SERPINF2
3 cellular protein metabolic process GO:0044267 9.77 F2 F5 FGA PLG SERPINC1
4 negative regulation of peptidase activity GO:0010466 9.76 SERPINC1 SERPINE1 SERPINF2
5 platelet activation GO:0030168 9.74 ADAMTS13 F2 FGA
6 platelet degranulation GO:0002576 9.72 F5 FGA PLG SERPINE1 SERPINF2
7 negative regulation of fibrinolysis GO:0051918 9.65 F2 PLG SERPINE1 SERPINF2 THBD
8 blood coagulation GO:0007596 9.65 ADAMTS13 F2 F3 F5 F9 FGA
9 fibrinolysis GO:0042730 9.63 F2 FGA PLAT PLG SERPINE1 SERPINF2
10 positive regulation of collagen biosynthetic process GO:0032967 9.62 F2 SERPINF2
11 negative regulation of proteolysis GO:0045861 9.61 F2 PLAT
12 regulation of blood coagulation GO:0030193 9.61 F2 SERPINC1
13 signal peptide processing GO:0006465 9.6 F2 F9
14 blood coagulation, intrinsic pathway GO:0007597 9.58 F2 F9
15 negative regulation of blood coagulation GO:0030195 9.56 SERPINE1 THBD
16 positive regulation of blood coagulation GO:0030194 9.55 F2 SERPINE1
17 peptidyl-glutamic acid carboxylation GO:0017187 9.54 F2 F9
18 plasminogen activation GO:0031639 9.52 FGA PLAT
19 negative regulation of platelet activation GO:0010544 9.51 F2 THBD
20 acute inflammatory response to antigenic stimulus GO:0002438 9.49 ELANE SERPINC1
21 negative regulation of plasminogen activation GO:0010757 9.48 SERPINE1 SERPINF2
22 blood coagulation, extrinsic pathway GO:0007598 9.46 F3 F9
23 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.4 ELANE F2
24 hemostasis GO:0007599 9.28 ADAMTS13 F2 F3 F5 F9 FGA

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.73 ADAMTS13 ELANE F2 F9 PLAT PLG
2 receptor binding GO:0005102 9.72 F2 FGA PLAT PLG SERPINE1
3 peptidase inhibitor activity GO:0030414 9.61 SERPINC1 SERPINE1 SERPINF2
4 serine-type endopeptidase inhibitor activity GO:0004867 9.58 SERPINC1 SERPINE1 SERPINF2
5 serine-type peptidase activity GO:0008236 9.55 ELANE F2 F9 PLAT PLG
6 endopeptidase activity GO:0004175 9.54 ELANE F9 PLG
7 serine-type endopeptidase activity GO:0004252 9.43 ELANE F2 F3 F9 PLAT PLG
8 protease binding GO:0002020 9.02 ELANE F3 SERPINC1 SERPINE1 SERPINF2

Sources for Disseminated Intravascular Coagulation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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