DIC
MCID: DSS009
MIFTS: 62

Disseminated Intravascular Coagulation (DIC) malady

Immune diseases, Blood diseases categories
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Summaries for Disseminated Intravascular Coagulation

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Wikipedia:65 Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or... more...

MalaCards based summary: Disseminated Intravascular Coagulation, also known as defibrination syndrome, is related to purpura and acute promyelocytic leukemia. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Selected targets of C EBPalpha and FOXA2 and FOXA3 transcription factor networks. The drugs antithrombin iii, human and antithrombin iii,recombinant and the compounds certoparin and heparin sodium have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and prostate, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Disseminated Intravascular Coagulation

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Disseminated Intravascular Coagulation, Aliases & Descriptions:

Name: Disseminated Intravascular Coagulation 8 10 44 62
Defibrination Syndrome 8
 
Diffuse 8
Dic 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology8 DOID:11247
ICD9CM27 286.6
MeSH34 D004211
SNOMED-CT57 267563002, 67406007
NCIt39 C2992
ICD1025 D65

Related Diseases for Disseminated Intravascular Coagulation

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Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.6SERPINC1, ADAMTS13
2acute promyelocytic leukemia31.3THBD, F3, ELANE
3meningococcemia31.2F5, SERPINC1, THBD
4hepatitis31.1TAT, F2
5placental abruption31.1F5, SERPINC1
6malaria31.0TAT, ADAMTS13
7coronary thrombosis30.9F3, SERPINC1
8hemolytic-uremic syndrome30.9ADAMTS13, THBD
9hemophilia b30.7F3, F2
10hemolytic anemia30.7ADAMTS13, F3
11factor x deficiency30.6F5, F3, F2
12diabetes mellitus30.6SERPINC1, FGA, THBD
13septic shock30.5THBD, SERPINC1, F3, F5, FGA, ELANE
14antithrombin iii deficiency30.4F2, F5, SERPINC1
15hellp syndrome30.4SERPINC1, F5, ADAMTS13
16protein c deficiency30.4THBD, F2, F5, SERPINC1
17lupus erythematosus30.4F2, SERPINC1, THBD, F3, F5
18portal vein thrombosis30.4F2, F5, SERPINC1
19liver cirrhosis30.4F2, SERPINC1, TAT, F3, ADAMTS13
20protein s deficiency30.4F2, SERPINC1, F3, FGA, F5
21pulmonary embolism30.4F5, F3, SERPINC1, FGA, F2
22sepsis30.1F5, ELANE, F3, ADAMTS13, FGA, SERPINC1
23acute myocardial infarction30.0FGA, SERPINC1, F3, ADAMTS13, THBD
24systemic lupus erythematosus30.0THBD, FGA, ADAMTS13, F2, F3
25thromboembolism30.0THBD, SERPINC1, F3, F5, FGA, F2
26hemorrhagic disease29.9THBD, F2, F5, F3, SERPINC1
27vasculitis29.9TAT, FGA, ELANE, THBD, F2
28thrombocytopenia29.8THBD, SERPINC1, ADAMTS13, F3, F5, FGA
29myocardial infarction29.7FGA, F5, F3, ADAMTS13, TAT, SERPINC1
30antiphospholipid syndrome29.6SERPINC1, ADAMTS13, F5, F3, THBD, F2
31deficiency anemia29.5F3, TAT, ADAMTS13, F2
32leukemia10.9
33aneurysm10.8
34prostatitis10.8
35prostate cancer10.7
36aortic aneurysm10.7
37gastric cancer10.7
38pancreatitis10.6
39pneumonia10.6
40acute fatty liver of pregnancy10.6
41thrombotic thrombocytopenic purpura10.6
42endocarditis10.6
43endotheliitis10.6
44acute leukemia10.6
45adult-onset still's disease10.6
46cerebritis10.6
47tuberculosis10.6
48meningococcal infection10.6
49dissecting aortic aneurysm10.6
50sneddon syndrome10.5SERPINC1

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to disseminated intravascular coagulation

Symptoms for Disseminated Intravascular Coagulation

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Drugs & Therapeutics for Disseminated Intravascular Coagulation

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Drug clinical trials:

Search ClinicalTrials for Disseminated Intravascular Coagulation

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS62/NDF-RT40:

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Genetic Tests for Disseminated Intravascular Coagulation

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Anatomical Context for Disseminated Intravascular Coagulation

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MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

32
Testes, Liver, Prostate, Neutrophil, Bone, Bone marrow, Kidney, Endothelial, Brain, Heart, Thyroid, Spleen, Lung, Breast, Monocytes, T cells, Colon, Skin, B cells, Whole blood, Placenta, Myeloid, Tongue

Animal Models for Disseminated Intravascular Coagulation or affiliated genes

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MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7FGA, F5, SERPINC1, THBD
2MP:00107718.1FGA, F2, THBD, F3, F5
3MP:00053807.9F3, FGA, F5, SERPINC1, THBD, F2
4MP:00053857.8SERPINC1, THBD, F2, F5, FGA, F3
5MP:00036317.7F2, THBD, SERPINC1, F3, FGA, F5
6MP:00028737.7ELANE, F3, THBD, F2, ADAMTS13
7MP:00053977.3THBD, SERPINC1, F2, F3, ELANE, ADAMTS13
8MP:00053877.3FGA, ELANE, F2, F3, ADAMTS13, THBD
9MP:00053766.7FGA, F5, ELANE, F3, F2, ADAMTS13
10MP:00107686.7SERPINC1, FGA, ELANE, F5, F3, F2

Publications for Disseminated Intravascular Coagulation

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Articles related to Disseminated Intravascular Coagulation:

(show top 50)    (show all 761)
idTitleAuthorsYear
1
Disseminated intravascular coagulation does not play a major role in the pathogenesis of classical swine fever. (23107658)
2013
2
Current consideration and management of disseminated intravascular coagulation. (24319193)
2013
3
Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. (23361628)
2013
4
The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation]. (22225506)
2012
5
The utility of a diagnostic scoring system for disseminated intravascular coagulation. (22713612)
2012
6
Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature. (22844549)
2012
7
Kocher-DebrAc-SAcmAclaigne syndrome diagnosed by autopsy associated with disseminated intravascular coagulation. (21316996)
2012
8
Effects of antithrombin and gabexate mesilate on disseminated intravascular coagulation: a preliminary study. (22204993)
2012
9
Successful treatment of sepsis-induced disseminated intravascular coagulation in a patient with idiopathic thrombocytopenic purpura using recombinant human soluble thrombomodulin. (21240494)
2011
10
Disseminated Intravascular Coagulation, Hemoperitoneum, and Reversible Ischemic Neurological Deficit Complicating Anaphylaxis to Prophylactic Antibiotics during Cesarean Delivery: A Case Report and Review of Literature. (23705078)
2011
11
Model-based analysis of covariate effects on population pharmacokinetics of thrombomodulin alfa in patients with disseminated intravascular coagulation and normal subjects. (21098690)
2011
12
A difficult diagnosis case of prolonged thrombocytopenia with sepsis and disseminated intravascular coagulation. (20530051)
2011
13
Disseminated intravascular coagulation with intracranial haematoma in neonatal congenital syphilis. (20889622)
2011
14
Multiple organ infarctions following disseminated intravascular coagulation precipitated by sepsis in a healthy infant: a case report. (21186015)
2010
15
Disseminated intravascular coagulation complicating Epstein-Barr virus infection in a cardiac transplant recipient: a case report. (20620559)
2010
16
Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism. (20412432)
2010
17
Successful treatment of disseminated intravascular coagulation in a child with acute myelogenous leukaemia using recombinant thrombomodulin. (20346017)
2010
18
Disseminated intravascular coagulation in infectious disease. (20614389)
2010
19
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. (19062078)
2009
20
Pathophysiology and diagnostic criteria for disseminated intravascular coagulation associated with sepsis. (18158452)
2008
21
Anti-heparin/PF4 complexes by ELISA in patients with disseminated intravascular coagulation. (20224256)
2007
22
Case report: Disseminated intravascular coagulation as the presenting sign of metastatic prostate cancer. (17458572)
2007
23
Diagnosis and treatment of disseminated intravascular coagulation: a case report. (17604485)
2007
24
Thrombin generation by exposure of blood to endotoxin: a simple model to study disseminated intravascular coagulation. (16708116)
2006
25
Patient with disseminated intravascular coagulation as the first manifestation of adenocarcinoma of the prostate. Risks of prostatic biopsy. (16331297)
2006
26
A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis. (16988545)
2006
27
Disseminated Intravascular Coagulation syndrome - ENT surgeon's perspective. (23120357)
2006
28
Disseminated intravascular coagulation in cats. (17186846)
2006
29
Disseminated intravascular coagulation after laparoscopic multiple myomectomy with use of icodextrin: a case report. (16962537)
2006
30
Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. (16856920)
2006
31
Settling the score for disseminated intravascular coagulation. (16215405)
2005
32
Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation. (16363239)
2005
33
Good or poor responses of hemostatic molecular markers in patients with hematopoietic disorders after treatment of disseminated intravascular coagulation. (12643327)
2003
34
Disseminated intravascular coagulation]. (12806952)
2003
35
Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation. (14518675)
2003
36
Etiopathophysiology of disseminated intravascular coagulation. (14651143)
2003
37
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
38
Current drug treatment strategies for disseminated intravascular coagulation. (9617592)
1998
39
Antithrombin III in the treatment of disseminated intravascular coagulation]. (9045459)
1997
40
The antithrombotic effects of recombinant human soluble thrombomodulin (rhsTM) on tissue factor-induced disseminated intravascular coagulation in crab-eating monkeys (Macaca fascicularis). (9282791)
1997
41
Disseminated intravascular coagulation associated with granulocyte colony-stimulating factor therapy in a child with human immunodeficiency virus infection. (7538574)
1995
42
Phaeochromocytoma crisis in Sipple's syndrome with intrauterine death and disseminated intravascular coagulation. (15636849)
1993
43
Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report]. (1602615)
1992
44
Disseminated intravascular coagulation in liver cirrhosis. (1447499)
1992
45
The specific activity of plasminogen activator inhibitor-1 in disseminated intravascular coagulation with acute promyelocytic leukemia. (1708294)
1991
46
Disseminated intravascular coagulation masking neonatal hemophilia]. (2039186)
1991
47
Disseminated intravascular coagulation in dissecting aortic aneurysm. A case report. (7290724)
1981
48
Harlequin gangrene: a case report of unilateral gangrene of the leg and arm with myxedema, septicemia and disseminated intravascular coagulation. (642612)
1978
49
Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report. (1147459)
1975
50
Acute disseminated intravascular coagulation as the presenting and predominant clinical manifestation in a patient with a mucinous adenocarcinoma. (4376755)
1974

Variations for Disseminated Intravascular Coagulation

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Expression for genes affiliated with Disseminated Intravascular Coagulation

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Expression patterns in normal tissues for genes affiliated with Disseminated Intravascular Coagulation

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Pathways for genes affiliated with Disseminated Intravascular Coagulation

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Compounds for genes affiliated with Disseminated Intravascular Coagulation

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Compounds related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1certoparin449.5SERPINC1, F3, F2
2heparin sodium449.4THBD, F3, F2
3polybrene449.4F3, F2, SERPINC1
4hepaplastin449.3F2, SERPINC1, F3
5hemochron449.3F2, FGA, F3
6fibrinopeptide a449.1F2, THBD, SERPINC1, FGA
7epsilon aminocaproic acid449.1F3, SERPINC1, ELANE, F2
8ppack449.1SERPINC1, FGA, F2, F3
9benzamidine44 1110.0THBD, ELANE, F5, SERPINC1
10inogatran449.0SERPINC1, F5, F2, F3
11ecarin449.0F2, SERPINC1, F3, F5
12spectrozyme449.0F3, F5, F2, SERPINC1
13danaparoid449.0F2, SERPINC1, F3, F5
14rivaroxaban44 1110.0F2, SERPINC1, F3
15kaolin449.0F2, F3, F5
16cacl2448.9FGA, F5, F3, THBD
17nafamostat mesilate448.9ELANE, F5, SERPINC1, FGA
18gamma-carboxyglutamic acid448.9F5, F3, F2, THBD
19levonorgestrel44 61 28 1111.9F2, F3, SERPINC1, F5
20batroxobin448.8F2, F5, FGA
21cardiolipin44 119.8F2, THBD, F3, F5
22heparinoids448.7F5, F3, SERPINC1, THBD, F2
23ximelagatran44 119.7F5, F3, SERPINC1, THBD, F2
24ticlopidine44 119.7FGA, ADAMTS13, F3, SERPINC1
25fondaparinux448.7F2, F5, F3, SERPINC1, THBD
26protamine sulfate448.6TAT, SERPINC1, F2, F3, F5
27dextran sulfate448.6ELANE, SERPINC1, F3, F5
28hirugen448.6F2, FGA, F5, SERPINC1, THBD
29ancrod448.6FGA, F5, SERPINC1, THBD, F2
30homocysteine44 249.6F2, SERPINC1, F5, F3, THBD
31coumarin44 2 50 2411.5FGA, F5, F3, SERPINC1, F2
32dermatan sulfate448.3F5, SERPINC1, ELANE, F3, F2, THBD
33kininogen448.2F3, SERPINC1, ELANE, F5, THBD, F2
34ristocetin448.2F2, SERPINC1, F5, ADAMTS13, F3
35argatroban44 119.2SERPINC1, F2, THBD, FGA, F5, F3
36bivalirudin44 119.2SERPINC1, FGA, F5, F3, THBD, F2
37citrate448.2F2, THBD, SERPINC1, F3, ELANE, F5
38hirudin448.2F2, THBD, SERPINC1, F3, F5, FGA
39warfarin44 50 24 1111.2F3, F5, FGA, F2, SERPINC1, THBD
40prostacyclin448.2THBD, FGA, F5, ELANE, F3, SERPINC1
41protamine448.1SERPINC1, F3, F2, F5, FGA, ELANE
42desmopressin44 61 28 1110.9F2, ADAMTS13, F3, F5, THBD, SERPINC1
43lactate447.8F2, THBD, ELANE, FGA, TAT, F5
44aprotinin44 118.8FGA, F5, ELANE, F3, SERPINC1, THBD
45aspirin44 50 28 2410.7THBD, SERPINC1, F5, F2, FGA, F3
46endotoxin447.7THBD, FGA, F3, ELANE, F5, ADAMTS13
47creatinine447.3FGA, F5, F3, ADAMTS13, THBD, F2
48fibrinogen446.5THBD, SERPINC1, ADAMTS13, F3, ELANE, F5
49heparin44 28 24 119.5F2, THBD, SERPINC1, ADAMTS13, F3, ELANE
50serine446.4F2, F5, FGA, TAT, ELANE, F3

GO Terms for genes affiliated with Disseminated Intravascular Coagulation

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Cellular components related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3FGA, F5
2blood microparticleGO:0725629.1FGA, SERPINC1, F2
3cell surfaceGO:0099868.0ELANE, F3, FGA, ADAMTS13, THBD
4extracellular regionGO:0055767.9F2, F5, ELANE, FGA, SERPINC1
5plasma membraneGO:0058867.5SERPINC1, FGA, F5, F2, THBD, F3
6extracellular spaceGO:0056157.1F3, F2, THBD, FGA, F5, SERPINC1

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:0507289.7ELANE, SERPINC1
2negative regulation of platelet activationGO:0105449.6THBD, F2
3negative regulation of fibrinolysisGO:0519189.5THBD, F2
4leukocyte migrationGO:0509009.2F2, THBD, ELANE
5proteolysisGO:0065088.4F2, ADAMTS13, ELANE
6platelet activationGO:0301688.1FGA, F5, ADAMTS13, F2
7blood coagulationGO:0075967.9FGA, F2, THBD, SERPINC1, F3, F5

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2ELANE, F3, SERPINC1
2serine-type endopeptidase activityGO:0042528.9F5, ELANE, F2
3protein bindingGO:0055156.2F2, THBD, SERPINC1, ADAMTS13, F3, ELANE

Products for genes affiliated with Disseminated Intravascular Coagulation

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Sources for Disseminated Intravascular Coagulation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet