DIC
MCID: DSS009
MIFTS: 51

Disseminated Intravascular Coagulation (DIC) malady

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Disseminated Intravascular Coagulation

Aliases & Descriptions for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 12 29 52 42 14 69
Diffuse or Disseminated Intravascular Coagulation 12
Defibrination Syndrome 12
Dic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11247
ICD10 33 D65
ICD9CM 35 286.6
MeSH 42 D004211
NCIt 47 C2992
SNOMED-CT 64 267563002 67406007
UMLS 69 C0012739

Summaries for Disseminated Intravascular Coagulation

MalaCards based summary : Disseminated Intravascular Coagulation, also known as diffuse or disseminated intravascular coagulation, is related to hemolytic-uremic syndrome and lupus erythematosus. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Tranexamic Acid and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, prostate and neutrophil, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 71 Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or... more...

Related Diseases for Disseminated Intravascular Coagulation

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
id Related Disease Score Top Affiliating Genes
1 hemolytic-uremic syndrome 30.2 F2 F3 SERPINC1
2 lupus erythematosus 30.0 F3 MB PLAT SERPINC1
3 myocardial infarction 28.2 ADAMTS13 F2 F3 F5 F7 FGA
4 purpura fulminans 11.8
5 dic in newborn 11.5
6 protein c deficiency 11.4
7 kidney cortex necrosis 11.1
8 leukemia 10.4
9 thrombosis 10.4
10 aneurysm 10.3
11 purpura 10.3
12 hemarthrosis 10.3 F2 F3
13 sertoli cell tumor 10.3 F3 SERPINC1
14 congenital insensitivity to pain with severe intellectual disability 10.3 F2 F5
15 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 10.3 F3 SERPINC1
16 absence of innominate vein 10.3 F5 SERPINE1
17 prostatitis 10.3
18 aminoaciduria 10.3 F5 SERPINE1
19 alpha-2-macroglobulin deficiency 10.3 F2 F3
20 freiberg's disease 10.3 F2 F3 SERPINC1
21 supraumbilical midabdominal raphe and facial cavernous hemangiomas 10.2 F2 F5
22 chorioretinal scar 10.2 F2 F3 SERPINC1
23 aortic aneurysm 10.2
24 vascular erectile tumor 10.2 F2 F5 SERPINC1
25 spinal cord lipoma 10.2 F2 F3 SERPINC1
26 mixed epithelial tumor of ovary 10.2 F2 SERPINC1
27 immunodeficiency 32a, mycobacteriosis, autosomal dominant 10.2 PLAT THBD
28 left-right axis malformations 10.2 F2 F5 SERPINC1
29 hereditary alpha tryptasemia syndrome 10.2 F2 F3 SERPINC1
30 stt3a-cdg and stt3b-cdg 10.2 F5 SERPINC1 SERPINE1
31 metaphyseal chondrodysplasia with cone-shaped epiphyses, normal hair, and normal hands 10.2 PLAT THBD
32 central retinal artery occlusion 10.2 F2 F3 SERPINC1
33 capillary hemangioma 10.2 F2 F3 SERPINC1
34 gastric cancer 10.2
35 prostate cancer 10.2
36 oxyphilic adenoma 10.2 F2 F5
37 cryptosporidiosis 10.2 F2 F5 SERPINC1
38 angular blepharoconjunctivitis 10.2 F2 F5 SERPINC1
39 hendra virus infection 10.2 F2 F3 F5
40 prostatic hypertrophy 10.2 F2 F3
41 craniopharyngioma 10.2 F3 SERPINE1 THBD
42 granulomatous hepatitis 10.2 F2 F3 SERPINC1
43 spinal multifocal clear cell meningioma 10.2 F3 F5 SERPINC1
44 lubinsky syndrome 10.2 F2 F5 SERPINE1
45 ischemic optic neuropathy 10.2 F2 SERPINC1 SERPINE1
46 low anorectal malformation 10.2 F2 F3 F5
47 citrulline transport defect 10.2 F2 FGA
48 pancreas adenocarcinoma 10.2 F2 SERPINC1 SERPINE1
49 cerebral calcifications opalescent teeth phosphaturia 10.2 PLAT SERPINE1
50 may-hegglin anomaly 10.2 F2 SERPINC1

Comorbidity relations with Disseminated Intravascular Coagulation via Phenotypic Disease Network (PDN): (show all 15)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Cardiac Arrest Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Left Ventricular Outflow Tract Obstruction Mitral Valve Disease
Prostate Cancer Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to Disseminated Intravascular Coagulation

Symptoms & Phenotypes for Disseminated Intravascular Coagulation

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ADAMTS13 ELANE F2 F3 F5 F7
2 cardiovascular system MP:0005385 10.23 F9 FGA MB PLAT SERPINC1 SERPINE1
3 hematopoietic system MP:0005397 10.14 MB PLAT SERPINC1 SERPINE1 THBD ADAMTS13
4 embryo MP:0005380 10.09 SERPINC1 TFPI THBD F2 F3 F5
5 immune system MP:0005387 10.06 ELANE F2 F3 F9 FGA PLAT
6 integument MP:0010771 9.8 F2 F3 F5 FGA SERPINE1 TFPI
7 mortality/aging MP:0010768 9.8 ADAMTS13 ELANE F2 F3 F5 F7
8 liver/biliary system MP:0005370 9.63 F5 F9 FGA SERPINC1 SERPINE1 THBD
9 respiratory system MP:0005388 9.1 F2 F3 MB PLAT SERPINE1 THBD

Drugs & Therapeutics for Disseminated Intravascular Coagulation

Drugs for Disseminated Intravascular Coagulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4 1197-18-8 5526
2
Magnesium Sulfate Approved, Vet_approved Phase 4 7487-88-9 24083
3 Coagulants Phase 4
4 Hemostatics Phase 4
5 Liver Extracts Phase 4
6 Platelet Aggregation Inhibitors Phase 4
7 Prasugrel hydrochloride Phase 4 389574-19-0
8 Thromboplastin Phase 4
9 Antifibrinolytic Agents Phase 4
10 Factor VIII Phase 4
11 Thrombin Phase 4
12 Calcium, Dietary Phase 4,Phase 3
13 Peripheral Nervous System Agents Phase 4
14 Analgesics Phase 4
15 Anesthetics Phase 4
16 Anti-Arrhythmia Agents Phase 4
17 Anticonvulsants Phase 4
18 calcium channel blockers Phase 4
19 Central Nervous System Depressants Phase 4
20 Tocolytic Agents Phase 4
21
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
22 HIV Protease Inhibitors Phase 2, Phase 3
23
protease inhibitors Phase 2, Phase 3
24 Serine Proteinase Inhibitors Phase 2, Phase 3
25 Trypsin Inhibitors Phase 2, Phase 3
26 Urinastatin Phase 2, Phase 3
27 Fibrinolytic Agents Phase 3
28 Anticoagulants Phase 3,Phase 2
29 Antithrombin III Phase 3,Phase 2
30 Antithrombins Phase 3,Phase 2
31 calcium heparin Phase 3
32 Pharmaceutical Solutions Phase 3,Phase 2
33 serine Nutraceutical Phase 2, Phase 3
34 Natriuretic Agents Phase 1
35 Natriuretic Peptide, Brain Phase 1
36
Epinephrine Approved, Vet_approved 51-43-4 5816
37
Substance P Investigational 33507-63-0 44359816
38 Plasminogen
39 Plasminogen Activator Inhibitor 1
40 Plasminogen Inactivators
41
Hydrogen sulfide 7783-06-4 402
42 neurokinin A
43 Adrenergic Agents
44 Adrenergic Agonists
45 Adrenergic alpha-Agonists
46 Adrenergic beta-Agonists
47 Anti-Asthmatic Agents
48 Autonomic Agents
49 Bronchodilator Agents
50 Epinephryl borate

Interventional clinical trials:

(show all 28)
id Name Status NCT ID Phase
1 Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment Completed NCT01704001 Phase 4
2 The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation Completed NCT01099566 Phase 4
3 A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor Completed NCT01800435 Phase 4
4 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4
5 The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia Unknown status NCT01865266 Phase 2, Phase 3
6 An Open-label Study of KW-3357 Completed NCT01384903 Phase 3
7 A Clinical Study of KW-3357 in Patients With DIC Completed NCT01384396 Phase 3
8 Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis Completed NCT02135770 Phase 3
9 Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation Not yet recruiting NCT02654561 Phase 3
10 A Phase 3 Clinical Study of KW-3357 in Patients With DIC Terminated NCT01384409 Phase 3
11 Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation Completed NCT00487656 Phase 2
12 Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis Terminated NCT00506519 Phase 2
13 Study to Look at the Effects of ART-123 on Patients With Sepsis and Disseminated Intravascular Coagulation (DIC) Withdrawn NCT01090115 Phase 2
14 A Comparison of B Type Natriuretic Peptide Levels and Hemodynamics Using the Nexfin Device in Healthy Pregnant and Preeclamptic Women - A Pilot Study Unknown status NCT02527018 Phase 1
15 4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock Unknown status NCT01211899
16 Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock Unknown status NCT02062970
17 Coagulation Factor Changes Associated With Postpartum Hysterectomies Completed NCT00456547
18 Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1- Completed NCT02862366
19 Study of New Biological Markers for Prediction of Severe Acute Pancreatitis Completed NCT00786591
20 TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL. Completed NCT02135627
21 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
22 The Procalcitonin and Survival Study Completed NCT00271752
23 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Recruiting NCT03135496
24 Hypercoagulation Screening in Cancer Recruiting NCT02622815
25 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
26 China Obstetrics Alliance Cohort Study Enrolling by invitation NCT03038555
27 Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery Not yet recruiting NCT03064152
28 Thrombin Generation and Thromboelastography in Non-overt DIC Terminated NCT00299949

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: disseminated intravascular coagulation

Genetic Tests for Disseminated Intravascular Coagulation

Genetic tests related to Disseminated Intravascular Coagulation:

id Genetic test Affiliating Genes
1 Disseminated Intravascular Coagulation 29

Anatomical Context for Disseminated Intravascular Coagulation

MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

39
Liver, Prostate, Neutrophil, Bone, Testes, Kidney, Bone Marrow

Publications for Disseminated Intravascular Coagulation

Articles related to Disseminated Intravascular Coagulation:

(show top 50) (show all 876)
id Title Authors Year
1
Population pharmacokinetics of thrombomodulin alfa in pediatric patients with hematological malignancy and disseminated intravascular coagulation. ( 27734584 )
2017
2
Erratum: Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ( 27834077 )
2017
3
Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation. ( 28011507 )
2017
4
Disseminated Intravascular Coagulation on Admission Predicts Complications and Poor Prognosis of Acute Pancreatitis: Analysis of the Nationwide Epidemiological Survey in Japan. ( 28085757 )
2017
5
Management of cancer-associated disseminated intravascular coagulation. ( 27067981 )
2016
6
Disseminated intravascular coagulation in paediatrics. ( 27540263 )
2016
7
Is antithrombin III for sepsis-associated disseminated intravascular coagulation really ineffective? ( 27143022 )
2016
8
Disseminated intravascular coagulation at diagnosis is a strong predictor for both arterial and venous thrombosis in newly diagnosed acute myeloid leukemia. ( 27354723 )
2016
9
Chronic disseminated intravascular coagulation induced by left atrial thrombus in a patient with giant "normal" heart: A case report. ( 28002328 )
2016
10
Evidence of NETosis in Septic Shock-induced Disseminated Intravascular Coagulation. ( 27488091 )
2016
11
Comparison of Procedure-Based and Diagnosis-Based Identifications of Severe Sepsis and Disseminated Intravascular Coagulation in Administrative Data. ( 27064132 )
2016
12
Fatal Hemorrhage from Kidney after Endovascular Repair for Chronic Type B Dissection Complicated with Disseminated Intravascular Coagulation. ( 28018508 )
2016
13
Factor XII-mediated contact activation related to poor prognosis in disseminated intravascular coagulation. ( 26706311 )
2016
14
Shock, acute disseminated intravascular coagulation, and microvascular thrombosis: is 'shock liver' the unrecognized provocateur of ischemic limb necrosis: comment. ( 27541323 )
2016
15
Neutrophil Fluorescence: A New Indicator of Cell Activation During Septic Shock-Induced Disseminated Intravascular Coagulation. ( 27441905 )
2016
16
Disseminated intravascular coagulation following administration of sunitinib. ( 27330781 )
2016
17
Efficacy and Bleeding Risk of Antithrombin Supplementation in Patients With Septic Disseminated Intravascular Coagulation: A Third Survey. ( 27161759 )
2016
18
OC-10 - Disseminated intravascular coagulation at diagnosis strongly predicts both arterial and venous thrombosis in acute myeloid leukemia patients. ( 27161682 )
2016
19
Disseminated intravascular coagulation with positive D-dimer: a controversial clinical feature in severe congenital factor XIII deficiency in southeast Iran. ( 26836269 )
2016
20
Acute kidney injury and disseminated intravascular coagulation due to mercuric chloride poisoning. ( 27194836 )
2016
21
Successful treatments with polymyxin B hemoperfusion and recombinant human thrombomodulin for fulminant Clostridium difficile-associated colitis with septic shock and disseminated intravascular coagulation: a case report. ( 27468959 )
2016
22
Case of disseminated intravascular coagulation after honey Bee sting. ( 27728595 )
2016
23
Disseminated Intravascular Coagulation: A Practical Approach. ( 27031011 )
2016
24
The impact of disseminated intravascular coagulation on the outcome of cancer patients with venous thromboembolism: Erratum. ( 27380477 )
2016
25
Inherited Thrombotic Thrombocytopenic Purpura (Upshaw Schulman Syndrome) as Differential Diagnosis to Neonatal Septicaemia with Disseminated Intravascular Coagulation - a Case Series. ( 27383044 )
2016
26
Successful Renal Transplantation of Deceased Donor Kidneys With 100% Glomerular Fibrin Thrombi and Acute Renal Failure Due To Disseminated Intravascular Coagulation. ( 27490412 )
2016
27
Sepsis and disseminated intravascular coagulation. ( 27011792 )
2016
28
Blood Component Utilization for Disseminated Intravascular Coagulation (DIC) Cases with Respect to Underlying Condition. ( 27065584 )
2016
29
Can recombinant human thrombomodulin increase survival among patients with severe septic-induced disseminated intravascular coagulation: a single-centre, open-label, randomised controlled trial. ( 28039291 )
2016
30
Diffuse Cutaneous Bullous Mastocytosis and Disseminated Intravascular Coagulation Postvaccination: A Case Report. ( 27436822 )
2016
31
Assessment of Haemostasis in Disseminated Intravascular Coagulation by Use of Point-of-Care Assays and Routine Coagulation Tests, in Critically Ill Patients; A Prospective Observational Study. ( 26959974 )
2016
32
Pathological findings in a case of bone marrow carcinosis due to gastric cancer complicated by disseminated intravascular coagulation and thrombotic microangiopathy. ( 27357318 )
2016
33
Antithrombin Supplementation and Mortality in Sepsis-Induced Disseminated Intravascular Coagulation: A Multicenter Retrospective Observational Study. ( 27548460 )
2016
34
Spontaneous intracranial hypotension complicated by malignancyinduced disseminated intravascular coagulation: A case report. ( 27854087 )
2016
35
Disseminated Intravascular Coagulation. ( 28013226 )
2016
36
Disseminated intravascular coagulation in the HELLP syndrome: how much do we really know? ( 27181089 )
2016
37
Priapism as the Presenting Complaint in Fatal Group A Streptococcal Induced Disseminated Intravascular Coagulation. ( 27989251 )
2016
38
Massive Bleeding as the First Clinical Manifestation of Metastatic Prostate Cancer due to Disseminated Intravascular Coagulation with Enhanced Fibrinolysis. ( 27803823 )
2016
39
The efficacy and safety of antithrombin and recombinant human thrombomodulin combination therapy in patients with severe sepsis and disseminated intravascular coagulation. ( 27546744 )
2016
40
Recombinant human soluble thrombomodulin and mortality in sepsis-induced disseminated intravascular coagulation. A multicentre retrospective study. ( 26939575 )
2016
41
Evaluation of Disseminated Intravascular Coagulation Scores in Critically Ill Pediatric Patients. ( 27028791 )
2016
42
Shock, acute disseminated intravascular coagulation, and microvascular thrombosis: is 'shock liver' the unrecognized provocateur of ischemic limb necrosis: reply. ( 27608440 )
2016
43
Comparison of Two Diagnostic Scores of Disseminated Intravascular Coagulation in Pregnant Women Admitted to the ICU. ( 27861597 )
2016
44
Disseminated Intravascular Coagulation in Secondary Glioblastoma due to Excessive Intraoperative Bleeding: Case Report and Review of the Literature. ( 26921703 )
2016
45
Intramural hematoma of the colon caused by double-balloon enteroscopy in a patient with chronic disseminated intravascular coagulation. ( 27008555 )
2016
46
Helicobacter pylori Eradication Therapy for Thrombocytopenia after Surgery for Abdominal Aortic Aneurysm with Disseminated Intravascular Coagulation. ( 28018509 )
2016
47
Blue Toe Syndrome as an Early Sign of Disseminated Intravascular Coagulation. ( 27274647 )
2016
48
Antithrombin supplementation and risk of bleeding in patients with sepsis-associated disseminated intravascular coagulation. ( 27479532 )
2016
49
Lamotrigine-Induced Disseminated Intravascular Coagulation With Anticonvulsant Hypersensitivity Syndrome: A Case Report. ( 27063814 )
2016
50
Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ( 27578502 )
2016

Variations for Disseminated Intravascular Coagulation

Expression for Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for Disseminated Intravascular Coagulation

Pathways related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 F2 F3 F5 F7 F9 FGA
2
Show member pathways
12.63 F2 F3 F5 F7 F9 FGA
3
Show member pathways
12.04 F2 F7 PLAT SERPINE1
4 11.88 F2 F3 F5 F7 F9 FGA
5
Show member pathways
11.67 F2 F7 F9
6
Show member pathways
11.61 F2 F3 F5 F7 F9 FGA
7 11.6 F3 SERPINE1 THBD
8 10.72 F2 F7 F9
9 10.61 PLAT SERPINE1 SERPINF2

GO Terms for Disseminated Intravascular Coagulation

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.86 ADAMTS13 ELANE F3 FGA PLAT SERPINF2
2 extracellular region GO:0005576 9.77 ADAMTS13 ELANE F2 F3 F5 F7
3 blood microparticle GO:0072562 9.73 F2 FGA SERPINC1 SERPINF2
4 endoplasmic reticulum lumen GO:0005788 9.7 ADAMTS13 F2 F5 F7 F9 FGA
5 Golgi lumen GO:0005796 9.65 F2 F7 F9
6 platelet alpha granule lumen GO:0031093 9.62 F5 FGA SERPINE1 SERPINF2
7 platelet alpha granule GO:0031091 9.49 F5 FGA
8 extracellular space GO:0005615 9.47 ADAMTS13 ELANE F2 F3 F5 F7
9 fibrinogen complex GO:0005577 9.46 FGA SERPINF2
10 serine-type peptidase complex GO:1905286 9.37 F3 F7
11 extracellular exosome GO:0070062 10.1 ELANE F2 F3 F9 FGA MB

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.98 ADAMTS13 ELANE F2 F5 F7 F9
2 cellular protein metabolic process GO:0044267 9.89 F2 F5 FGA SERPINC1
3 ER to Golgi vesicle-mediated transport GO:0006888 9.86 F2 F5 F7 F9
4 negative regulation of endopeptidase activity GO:0010951 9.83 SERPINC1 SERPINE1 SERPINF2 TFPI
5 cellular response to lipopolysaccharide GO:0071222 9.81 ADAMTS13 SERPINE1 TFPI
6 platelet degranulation GO:0002576 9.81 F5 FGA SERPINE1 SERPINF2
7 negative regulation of peptidase activity GO:0010466 9.8 SERPINC1 SERPINE1 SERPINF2 TFPI
8 platelet activation GO:0030168 9.78 ADAMTS13 F2 F5 FGA
9 protein processing GO:0016485 9.77 ADAMTS13 F3 F7
10 blood coagulation GO:0007596 9.7 ADAMTS13 F2 F3 F5 F7 F9
11 positive regulation of collagen biosynthetic process GO:0032967 9.65 F2 SERPINF2
12 negative regulation of proteolysis GO:0045861 9.64 F2 PLAT
13 regulation of blood coagulation GO:0030193 9.64 F2 SERPINC1
14 blood coagulation, intrinsic pathway GO:0007597 9.63 F2 F9
15 signal peptide processing GO:0006465 9.63 F2 F7 F9
16 negative regulation of blood coagulation GO:0030195 9.62 SERPINE1 THBD
17 positive regulation of positive chemotaxis GO:0050927 9.62 F3 F7
18 negative regulation of fibrinolysis GO:0051918 9.62 F2 SERPINE1 SERPINF2 THBD
19 plasminogen activation GO:0031639 9.61 FGA PLAT
20 negative regulation of platelet activation GO:0010544 9.61 F2 THBD
21 acute inflammatory response to antigenic stimulus GO:0002438 9.58 ELANE SERPINC1
22 negative regulation of plasminogen activation GO:0010757 9.58 SERPINE1 SERPINF2
23 positive regulation of blood coagulation GO:0030194 9.58 F2 F7 SERPINE1
24 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.57 ELANE F2
25 blood coagulation, extrinsic pathway GO:0007598 9.56 F3 F7 F9 TFPI
26 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.55 F3 F7
27 fibrinolysis GO:0042730 9.55 F2 FGA PLAT SERPINE1 SERPINF2
28 response to vitamin K GO:0032571 9.54 F5 F7
29 peptidyl-glutamic acid carboxylation GO:0017187 9.54 F2 F7 F9
30 hemostasis GO:0007599 9.32 ADAMTS13 F2 F3 F5 F7 F9

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.85 ADAMTS13 F2 F7 F9 THBD
2 receptor binding GO:0005102 9.8 F2 F7 FGA PLAT SERPINE1
3 peptidase activity GO:0008233 9.8 ADAMTS13 ELANE F2 F7 F9 PLAT
4 peptidase inhibitor activity GO:0030414 9.67 SERPINC1 SERPINE1 SERPINF2 TFPI
5 heparin binding GO:0008201 9.65 ELANE F2 SERPINC1
6 endopeptidase activity GO:0004175 9.61 ELANE F7 F9
7 serine-type endopeptidase inhibitor activity GO:0004867 9.56 SERPINC1 SERPINE1 SERPINF2 TFPI
8 serine-type peptidase activity GO:0008236 9.55 ELANE F2 F7 F9 PLAT
9 protease binding GO:0002020 9.35 ELANE F3 SERPINC1 SERPINE1 SERPINF2
10 serine-type endopeptidase activity GO:0004252 9.17 ELANE F2 F3 F5 F7 F9

Sources for Disseminated Intravascular Coagulation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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