DIC
MCID: DSS009
MIFTS: 62

Disseminated Intravascular Coagulation (DIC) malady

Immune diseases, Blood diseases categories

Summaries for Disseminated Intravascular Coagulation

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66Wikipedia, 34MalaCards
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Wikipedia:66 Disseminated intravascular coagulation (DIC), also known as disseminated intravascular coagulopathy or... more...

MalaCards: Disseminated Intravascular Coagulation, also known as dissemin. intravascular coag., is related to purpura and sepsis. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Selected targets of C EBPalpha and FOXA2 and FOXA3 transcription factor networks. The drugs antithrombin iii, human and antithrombin iii,recombinant and the compounds certoparin and heparin sodium have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and prostate, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Disseminated Intravascular Coagulation

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

disseminated intravascular coagulation 9 11 46 63
dissemin. intravascular coag. 9
defibrination syndrome 9
diffuse 9
dic 9


External Ids:

Disease Ontology9 DOID:11247
ICD9CM28 286.6
MeSH36 D004211
SNOMED-CT59 267563002, 67406007
NCIt41 C2992
ICD1026 D65

Related Diseases for Disseminated Intravascular Coagulation

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18GeneCards, 19GeneDecks
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Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.3SERPINC1, ADAMTS13
2sepsis31.3F5, ELANE, F3, ADAMTS13, FGA, SERPINC1
3purpura fulminans31.2SERPINC1, F5
4acute promyelocytic leukemia31.1THBD, F3, ELANE
5meningococcemia31.1F5, SERPINC1, THBD
6hepatitis31.0TAT, F2
7septic shock31.0THBD, SERPINC1, F3, F5, FGA, ELANE
8protein s deficiency30.9SERPINC1, F5
9liver cirrhosis30.8F2, SERPINC1, TAT, F3, ADAMTS13
10placental abruption30.8F5, SERPINC1
11pulmonary embolism30.7F5, F3, SERPINC1, FGA, F2
12malaria30.7TAT, ADAMTS13
13hemolytic-uremic syndrome30.7ADAMTS13, THBD
14thrombocytopenia30.7THBD, SERPINC1, ADAMTS13, F3, F5, FGA
15hemolytic anemia30.7ADAMTS13, F3
16lupus erythematosus30.7F2, SERPINC1, THBD, F3, F5
17factor x deficiency30.5F5, F3, F2
18diabetes mellitus30.5SERPINC1, FGA, THBD
19systemic lupus erythematosus30.5THBD, FGA, ADAMTS13, F2, F3
20hellp syndrome30.5SERPINC1, F5, ADAMTS13
21protein c deficiency30.5THBD, F2, F5, SERPINC1
22thromboembolism30.5THBD, SERPINC1, F3, F5, FGA, F2
23antiphospholipid syndrome30.4SERPINC1, ADAMTS13, F5, F3, THBD, F2
24coronary thrombosis30.4F3, SERPINC1
25myocardial infarction30.4FGA, F5, F3, ADAMTS13, TAT, SERPINC1
26acute myocardial infarction30.4FGA, SERPINC1, F3, ADAMTS13, THBD
27hemophilia b30.4F3, F2
28antithrombin iii deficiency30.3F2, F5, SERPINC1
29portal vein thrombosis30.3F2, F5, SERPINC1
30hemorrhagic disease30.2THBD, F2, F5, F3, SERPINC1
31vasculitis30.2TAT, FGA, ELANE, THBD, F2
32deficiency anemia29.8F3, TAT, ADAMTS13, F2
33leukemia10.9
34aneurysm10.8
35prostatitis10.7
36aortic aneurysm10.7
37prostate cancer10.7
38acute fatty liver of pregnancy10.6
39endocarditis10.6
40pancreatitis10.6
41endotheliitis10.6
42thrombotic thrombocytopenic purpura10.6
43acute leukemia10.6
44cerebritis10.6
45pneumonia10.6
46tuberculosis10.6
47meningococcal infection10.6
48dissecting aortic aneurysm10.6
49adenocarcinoma10.5
50bone marrow necrosis10.5

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to disseminated intravascular coagulation

Symptoms for Disseminated Intravascular Coagulation

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Drugs & Therapeutics for Disseminated Intravascular Coagulation

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Disseminated Intravascular Coagulation

Drug clinical trials:

Search ClinicalTrials for Disseminated Intravascular Coagulation

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Search CenterWatch for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS63/NDF-RT42:

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Genetic Tests for Disseminated Intravascular Coagulation

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Anatomical Context for Disseminated Intravascular Coagulation

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34MalaCards
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MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

34
Testes, Liver, Prostate, Bone, Bone marrow, Endothelial, Kidney, Brain, Heart, T cells, Lung, Thyroid, Monocytes, B cells, Skin, Breast, Colon, Spleen, Placenta, Myeloid, Whole blood, Tongue

Animal Models for Disseminated Intravascular Coagulation or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7FGA, F5, SERPINC1, THBD
2MP:00107718.1F2, THBD, F3, F5, FGA
3MP:00053807.9F2, THBD, SERPINC1, F3, F5, FGA
4MP:00053857.8F2, THBD, SERPINC1, F3, F5, FGA
5MP:00036317.7F2, THBD, SERPINC1, F3, F5, FGA
6MP:00028737.7F2, THBD, ADAMTS13, F3, ELANE
7MP:00053977.3F2, THBD, SERPINC1, ADAMTS13, F3, ELANE
8MP:00053877.3F2, THBD, SERPINC1, ADAMTS13, F3, ELANE
9MP:00053766.7FGA, F2, THBD, SERPINC1, ADAMTS13, F3
10MP:00107686.7F2, THBD, SERPINC1, ADAMTS13, F3, ELANE

Publications for Disseminated Intravascular Coagulation

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53PubMed
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Articles related to Disseminated Intravascular Coagulation:

(show top 50)    (show all 731)
idTitleAuthorsYear
1
Disseminated intravascular coagulation does not play a major role in the pathogenesis of classical swine fever. (23107658)
2013
2
Current consideration and management of disseminated intravascular coagulation. (24319193)
2013
3
Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. (23361628)
2013
4
The withdrawal of Activated Protein C from the use in patients with severe sepsis and DIC [Amendment to the BCSH guideline on disseminated intravascular coagulation]. (22225506)
2012
5
The utility of a diagnostic scoring system for disseminated intravascular coagulation. (22713612)
2012
6
Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature. (22844549)
2012
7
Kocher-DebrAc-SAcmAclaigne syndrome diagnosed by autopsy associated with disseminated intravascular coagulation. (21316996)
2012
8
Effects of antithrombin and gabexate mesilate on disseminated intravascular coagulation: a preliminary study. (22204993)
2012
9
Successful treatment of sepsis-induced disseminated intravascular coagulation in a patient with idiopathic thrombocytopenic purpura using recombinant human soluble thrombomodulin. (21240494)
2011
10
Disseminated Intravascular Coagulation, Hemoperitoneum, and Reversible Ischemic Neurological Deficit Complicating Anaphylaxis to Prophylactic Antibiotics during Cesarean Delivery: A Case Report and Review of Literature. (23705078)
2011
11
Model-based analysis of covariate effects on population pharmacokinetics of thrombomodulin alfa in patients with disseminated intravascular coagulation and normal subjects. (21098690)
2011
12
A difficult diagnosis case of prolonged thrombocytopenia with sepsis and disseminated intravascular coagulation. (20530051)
2011
13
Disseminated intravascular coagulation with intracranial haematoma in neonatal congenital syphilis. (20889622)
2011
14
Multiple organ infarctions following disseminated intravascular coagulation precipitated by sepsis in a healthy infant: a case report. (21186015)
2010
15
Disseminated intravascular coagulation complicating Epstein-Barr virus infection in a cardiac transplant recipient: a case report. (20620559)
2010
16
Disseminated intravascular coagulation or extended intravascular coagulation in massive pulmonary embolism. (20412432)
2010
17
Successful treatment of disseminated intravascular coagulation in a child with acute myelogenous leukaemia using recombinant thrombomodulin. (20346017)
2010
18
Disseminated intravascular coagulation in infectious disease. (20614389)
2010
19
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. (19062078)
2009
20
Pathophysiology and diagnostic criteria for disseminated intravascular coagulation associated with sepsis. (18158452)
2008
21
Anti-heparin/PF4 complexes by ELISA in patients with disseminated intravascular coagulation. (20224256)
2007
22
Case report: Disseminated intravascular coagulation as the presenting sign of metastatic prostate cancer. (17458572)
2007
23
Diagnosis and treatment of disseminated intravascular coagulation: a case report. (17604485)
2007
24
Thrombin generation by exposure of blood to endotoxin: a simple model to study disseminated intravascular coagulation. (16708116)
2006
25
Patient with disseminated intravascular coagulation as the first manifestation of adenocarcinoma of the prostate. Risks of prostatic biopsy. (16331297)
2006
26
A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis. (16988545)
2006
27
Disseminated Intravascular Coagulation syndrome - ENT surgeon's perspective. (23120357)
2006
28
Disseminated intravascular coagulation in cats. (17186846)
2006
29
Disseminated intravascular coagulation after laparoscopic multiple myomectomy with use of icodextrin: a case report. (16962537)
2006
30
Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation. (16856920)
2006
31
Settling the score for disseminated intravascular coagulation. (16215405)
2005
32
Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation. (16363239)
2005
33
Good or poor responses of hemostatic molecular markers in patients with hematopoietic disorders after treatment of disseminated intravascular coagulation. (12643327)
2003
34
Disseminated intravascular coagulation]. (12806952)
2003
35
Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation. (14518675)
2003
36
Etiopathophysiology of disseminated intravascular coagulation. (14651143)
2003
37
Osteonecrosis after meningococcemia and disseminated intravascular coagulation. (14628777)
2003
38
Current drug treatment strategies for disseminated intravascular coagulation. (9617592)
1998
39
Antithrombin III in the treatment of disseminated intravascular coagulation]. (9045459)
1997
40
The antithrombotic effects of recombinant human soluble thrombomodulin (rhsTM) on tissue factor-induced disseminated intravascular coagulation in crab-eating monkeys (Macaca fascicularis). (9282791)
1997
41
Disseminated intravascular coagulation associated with granulocyte colony-stimulating factor therapy in a child with human immunodeficiency virus infection. (7538574)
1995
42
Phaeochromocytoma crisis in Sipple's syndrome with intrauterine death and disseminated intravascular coagulation. (15636849)
1993
43
Megakaryoblastic transformation associated with disseminated intravascular coagulation in the course of polycythemia vera: a case report]. (1602615)
1992
44
Disseminated intravascular coagulation in liver cirrhosis. (1447499)
1992
45
The specific activity of plasminogen activator inhibitor-1 in disseminated intravascular coagulation with acute promyelocytic leukemia. (1708294)
1991
46
Disseminated intravascular coagulation masking neonatal hemophilia]. (2039186)
1991
47
Disseminated intravascular coagulation in dissecting aortic aneurysm. A case report. (7290724)
1981
48
Harlequin gangrene: a case report of unilateral gangrene of the leg and arm with myxedema, septicemia and disseminated intravascular coagulation. (642612)
1978
49
Dilantin-induced disseminated intravascular coagulation with purpura fulminans. A case report. (1147459)
1975
50
Acute disseminated intravascular coagulation as the presenting and predominant clinical manifestation in a patient with a mucinous adenocarcinoma. (4376755)
1974

Variations for Disseminated Intravascular Coagulation

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Expression for genes affiliated with Disseminated Intravascular Coagulation

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for genes affiliated with Disseminated Intravascular Coagulation

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 54QIAGEN, 55R&D Systems, 31KEGG
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Compounds for genes affiliated with Disseminated Intravascular Coagulation

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB, 52PharmGKB
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Compounds related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show top 50)    (show all 157)
idCompoundScoreTop Affiliating Genes
1certoparin469.5SERPINC1, F3, F2
2heparin sodium469.4THBD, F3, F2
3polybrene469.4F3, F2, SERPINC1
4hepaplastin469.3F2, SERPINC1, F3
5hemochron469.3F2, FGA, F3
6fibrinopeptide a469.1F2, THBD, SERPINC1, FGA
7epsilon aminocaproic acid469.1F3, SERPINC1, ELANE, F2
8ppack469.1SERPINC1, FGA, F2, F3
9benzamidine46 1210.0THBD, ELANE, F5, SERPINC1
10inogatran469.0SERPINC1, F5, F2, F3
11ecarin469.0F2, SERPINC1, F3, F5
12spectrozyme469.0F3, F5, F2, SERPINC1
13danaparoid469.0F2, SERPINC1, F3, F5
14rivaroxaban46 1210.0F2, SERPINC1, F3
15kaolin469.0F2, F3, F5
16cacl2468.9FGA, F5, F3, THBD
17nafamostat mesilate468.9ELANE, F5, SERPINC1, FGA
18gamma-carboxyglutamic acid468.9F5, F3, F2, THBD
19levonorgestrel46 62 30 1211.9F2, F3, SERPINC1, F5
20batroxobin468.8F2, F5, FGA
21cardiolipin46 129.8F2, THBD, F3, F5
22heparinoids468.7F5, F3, SERPINC1, THBD, F2
23ximelagatran46 129.7F5, F3, SERPINC1, THBD, F2
24ticlopidine46 129.7FGA, ADAMTS13, F3, SERPINC1
25fondaparinux468.7F2, F5, F3, SERPINC1, THBD
26protamine sulfate468.6TAT, SERPINC1, F2, F3, F5
27dextran sulfate468.6ELANE, SERPINC1, F3, F5
28hirugen468.6F2, FGA, F5, SERPINC1, THBD
29ancrod468.6FGA, F5, SERPINC1, THBD, F2
30homocysteine46 259.6F2, SERPINC1, F5, F3, THBD
31coumarin46 3 52 2511.5FGA, F5, F3, SERPINC1, F2
32dermatan sulfate468.3F5, SERPINC1, ELANE, F3, F2, THBD
33kininogen468.2F3, SERPINC1, ELANE, F5, THBD, F2
34ristocetin468.2F2, SERPINC1, F5, ADAMTS13, F3
35argatroban46 129.2SERPINC1, F2, THBD, FGA, F5, F3
36bivalirudin46 129.2SERPINC1, FGA, F5, F3, THBD, F2
37citrate468.2F2, THBD, SERPINC1, F3, ELANE, F5
38hirudin468.2F2, THBD, SERPINC1, F3, F5, FGA
39warfarin46 52 25 1211.2F3, F5, FGA, F2, SERPINC1, THBD
40prostacyclin468.2THBD, FGA, F5, ELANE, F3, SERPINC1
41protamine468.1SERPINC1, F3, F2, F5, FGA, ELANE
42desmopressin46 62 30 1210.9F2, ADAMTS13, F3, F5, THBD, SERPINC1
43lactate467.8F2, THBD, ELANE, FGA, TAT, F5
44aprotinin46 128.8FGA, F5, ELANE, F3, SERPINC1, THBD
45aspirin46 52 30 2510.7THBD, SERPINC1, F5, F2, FGA, F3
46endotoxin467.7THBD, FGA, F3, ELANE, F5, ADAMTS13
47creatinine467.3FGA, F5, F3, ADAMTS13, THBD, F2
48fibrinogen466.5THBD, SERPINC1, ADAMTS13, F3, ELANE, F5
49heparin46 30 25 129.5F2, THBD, SERPINC1, ADAMTS13, F3, ELANE
50serine466.4F2, F5, FGA, TAT, ELANE, F3

GO Terms for genes affiliated with Disseminated Intravascular Coagulation

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17Gene Ontology
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Cellular components related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3FGA, F5
2blood microparticleGO:0725629.1F2, SERPINC1, FGA
3cell surfaceGO:0099868.0FGA, ELANE, F3, ADAMTS13, THBD
4extracellular regionGO:0055767.9FGA, F5, ELANE, SERPINC1, F2
5plasma membraneGO:0058867.5F2, THBD, SERPINC1, F3, F5, FGA
6extracellular spaceGO:0056157.1FGA, F2, THBD, SERPINC1, ADAMTS13, F3

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:0507289.7ELANE, SERPINC1
2negative regulation of platelet activationGO:0105449.6THBD, F2
3negative regulation of fibrinolysisGO:0519189.5THBD, F2
4leukocyte migrationGO:0509009.2F2, THBD, ELANE
5proteolysisGO:0065088.4F2, ADAMTS13, ELANE
6platelet activationGO:0301688.1FGA, F5, ADAMTS13, F2
7blood coagulationGO:0075967.9FGA, F2, THBD, SERPINC1, F3, F5

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2ELANE, F3, SERPINC1
2serine-type endopeptidase activityGO:0042528.9F5, ELANE, F2
3protein bindingGO:0055156.2F2, THBD, SERPINC1, ADAMTS13, F3, ELANE

Products for genes affiliated with Disseminated Intravascular Coagulation

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  • Antibodies
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Sources for Disseminated Intravascular Coagulation

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet