Distal Hereditary Motor Neuropathy, Type Ii malady

Genetics Home Reference: Distal hereditary motor neuropathy, type II is a progressive disorder that affects nerve cells in the spinal cord. It results in muscle weakness and affects movement, primarily in the legs.¹⁷

MalaCards: Distal Hereditary Motor Neuropathy, Type Ii, also known as inherited neuropathy, is related to distal hereditary motor neuropathy and neuropathy. An important gene associated with Distal Hereditary Motor Neuropathy, Type Ii is HCAR3 (hydroxycarboxylic acid receptor 3), and among its related pathways are Loss of Nlp from mitotic centrosomes and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. The compounds albendazole and pironetin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord.

distal hereditary motor neuropathy, type ii 17 inherited neuropathy 43

Disease types for distal hereditary motor neuropathy family:

distal hereditary motor neuropathy type v	distal hereditary motor neuropathy, type ii

Diseases related to distal hereditary motor neuropathy, type ii by text searches and GeneDecks gene sharing:

(show all 33)

id	Related Disease	Score	Top Affiliating Genes
1	distal hereditary motor neuropathy	29.6	CLIP1, ARF3, HSPB8, TUBA1A, TUBA1B, TUBA1C
2	neuropathy	29.5	ARF3, HSPB8, TUBA1A, CLIP1, TUBA1C, TUBB
3	chondroblastoma	12.5	TUBB, TUBA1C
4	pachygyria	12.4	TUBA1A, TUBA1B
5	pulmonary sclerosing hemangioma	12.3	TUBA1B, TUBA1A
6	estrogen-receptor positive breast cancer	12.3	TUBA1B, HSPB8
7	sclerosing hemangioma	12.1	TUBA1A, TUBA1B
8	cerebral amyloid angiopathy	11.9	TUBB, TUBA1B, HSPB8
9	malaria	10.0	TUBA1A, TUBA1B, DDX23, TUBA1C, TUBB, ARF3
10	charcot-marie-tooth disease	6.9
11	tooth disease	6.9
12	hereditary neuropathy with liability to pressure palsy	5.5
13	hereditary type 1 neuropathy	5.5
14	hereditary type 2 neuropathy	5.5
15	age related macular degeneration	5.5
16	hereditary neuropathies	5.5
17	charcot-marie-tooth neuropathy type 1	5.5
18	macular degeneration	5.5
19	charcot-marie-tooth neuropathy type 2	5.5
20	refsum disease	5.5
21	dnmt1-related dementia, deafness, and sensory neuropathy	5.5
22	riley-day syndrome	5.5
23	distal hereditary motor neuronopathy type viib	5.5
24	werdnig-hoffmann disease	5.5
25	distal hereditary motor neuronopathy, type iia	5.5
26	was-related disorders	5.5
27	distal hereditary motor neuronopathy, type iib	5.5
28	distal hereditary motor neuronopathy, type iic	5.5
29	distal hereditary motor neuropathy type v	5.5
30	distal spinal muscular atrophy 4	5.5
31	hereditary neuropathy with liability to pressure palsies	5.5
32	hereditary sensory and autonomic neuropathy type ii	5.5
33	hereditary sensory neuropathy type ia	5.5

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to distal hereditary motor neuropathy, type ii:

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Articles related to distal hereditary motor neuropathy, type ii:

id	Title	Authors	Year	Affiliating Genes
1	Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3. (12090300)	Irobi J.... Timmerman V.	2002	TUBB, TUBA1A, ARF3
2	Exclusion of 5 functional candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3. (11851982)	Irobi J.... Timmerman V.	2001	CLIP1
3	A clone contig of 12q24.3 encompassing the distal hereditary motor neuropathy type II gene. (10777663)	Irobi J.... Beuten J.	2000	HSPB8
4	Distal hereditary motor neuropathy type II (distal HMN II): mapping of a locus to chromosome 12q24. (8817349)	Timmerman V.... Van Broeckhoven C.	1996	HSPB8
5	Linkage analysis of distal hereditary motor neuropathy type II (distal HMN II) in a single pedigree. (1517763)	Timmerman V.... Van Broeckhoven C.	1992	HSPB8

Genes related to distal hereditary motor neuropathy, type ii according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	HCAR3	hydroxycarboxylic acid receptor 3	11.0	Publications
2	HSPB8	heat shock 22kDa protein 8	11.0	Publications
3	ARF3	ADP-ribosylation factor 3	11.0	Publications
4	TUBA1A	tubulin, alpha 1a	11.0	Publications
5	TUBA1C	tubulin, alpha 1c	11.0	Publications
6	TUBA1B	tubulin, alpha 1b	11.0	Publications
7	DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	11.0	Publications
8	CLIP1	CAP-GLY domain containing linker protein 1	11.0	Publications
9	TUBB	tubulin, beta class I	11.0	Publications

Pathways related to distal hereditary motor neuropathy, type ii according to GeneDecks:

(show all 25)

id	Pathway	Score	Top Affiliating Genes
1	Loss of Nlp from mitotic centrosomes38	9.5	TUBA1A, TUBB
2	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding38	9.2	TUBA1B, TUBA1C
3	Cytoskeleton remodeling Keratin filaments10	8.9	TUBB, TUBA1C, TUBA1B, TUBA1A
4	wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)41	8.9	TUBA1A, TUBA1B, TUBA1C, TUBB
5	Cell adhesion Gap junctions10	8.9	TUBA1A, TUBA1B, TUBA1C, TUBB
6	Cytoskeleton remodeling Neurofilaments10	8.9	TUBA1B, TUBA1A, TUBB, TUBA1C
7	Cytoskeleton remodeling_Keratin filaments41	8.9	TUBA1A, TUBA1B, TUBA1C, TUBB
8	Cytoskeleton remodeling_Neurofilaments41	8.9	TUBA1C, TUBA1A, TUBA1B, TUBB
9	Cell adhesion_Gap junctions41	8.9	TUBA1C, TUBB, TUBA1A, TUBA1B
10	Cytoskeleton remodeling Slit-Robo signaling10	8.9	TUBA1C, TUBB, TUBA1B, TUBA1A
11	Pathogenic Escherichia coli infection20	8.9	TUBA1A, TUBA1C, TUBA1B, TUBB
12	Development_Slit-Robo signaling41	8.9	TUBB, TUBA1C, TUBA1B, TUBA1A
13	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway10	8.9	TUBA1B, TUBA1C, TUBB, TUBA1A
14	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway41	8.8	TUBA1C, TUBB, TUBA1B, TUBA1A
15	Neurophysiological process Receptor-mediated axon growth repulsion10	8.8	TUBA1A, TUBA1B, TUBA1C, TUBB
16	Cytoskeleton remodeling Reverse signaling by ephrin B10	8.8	TUBA1B, TUBA1C, TUBB, TUBA1A
17	Neurophysiological process_Receptor-mediated axon growth repulsion41	8.8	TUBA1B, TUBB, TUBA1C, TUBA1A
18	Cytoplasmic microtubules10	8.8	TUBA1A, TUBA1B, TUBA1C, TUBB
19	Cytoskeleton remodeling_Reverse signaling by ephrin B41	8.8	TUBA1C, TUBA1A, TUBB, TUBA1B
20	Cell cycle Spindle assembly and chromosome separation10	8.7	TUBB, TUBA1C, TUBA1A, TUBA1B
21	Gap junction20	8.7	TUBA1C, TUBB, TUBA1B, TUBA1A
22	Cell cycle_Spindle assembly and chromosome separation41	8.7	TUBA1A, TUBA1B, TUBA1C, TUBB
23	Regulation of CFTR activity (norm and CF)41	8.6	TUBB, TUBA1A, TUBA1C, TUBA1B
24	Phagosome20	8.6	TUBA1A, TUBB, TUBA1C, TUBA1B
25	Cytoskeletal Signaling3	8.1	TUBA1B, TUBB, CLIP1, TUBA1A

Compounds related to distal hereditary motor neuropathy, type ii according to GeneDecks:

(show all 18)

id	Compound	Score	Top Affiliating Genes
1	albendazole32 9 9	11.7	TUBB, TUBA1A
2	pironetin32	9.7	TUBB, TUBA1B
3	podophyllotoxin32	9.6	TUBB, TUBA1B
4	estramustine32 9 9	11.5	TUBA1B, TUBB
5	colchicine32 9 9	11.4	TUBB, TUBA1B
6	cyanogen bromide32	9.3	TUBB, TUBA1B
7	2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE9 9	10.3	TUBA1A, TUBA1B, TUBA1C
8	vinblastine32 9 9	11.2	TUBA1A, TUBA1B, TUBB
9	rrna32	9.1	TUBB, TUBA1B
10	gdp32	9.1	TUBA1B, TUBB, ARF3
11	Epothilone D9 9	9.9	TUBA1B, TUBA1C, TUBA1A, TUBB
12	epothilone b32 9 9	10.9	TUBA1B, TUBB, TUBA1C, TUBA1A
13	vinblastine sulfate42	8.9	TUBB, TUBA1C, TUBA1B, TUBA1A
14	vincristine sulfate42	8.9	TUBB, TUBA1A, TUBA1C, TUBA1B
15	taxol42	8.8	TUBA1A, TUBB, TUBA1C, TUBA1B
16	xrp44x42	8.8	TUBA1A, TUBA1B, TUBA1C, TUBB
17	gtp32	8.3	ARF3, TUBA1B, TUBB, CLIP1
18	nocodazole32 42 9 9	11.0	CLIP1, TUBA1A, TUBA1B, TUBB, TUBA1C

Cellular components related to distal hereditary motor neuropathy, type ii according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasmic microtubule	GO:005881	8.7	CLIP1, TUBA1A, TUBA1B
2	microtubule	GO:005874	7.4	CLIP1, TUBA1A, TUBA1B, TUBA1C, TUBB

Biological processes related to distal hereditary motor neuropathy, type ii according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	de novo posttranslational protein folding	GO:051084	9.1	TUBA1A, TUBA1B, TUBA1C
2	protein folding	GO:006457	8.8	TUBA1C, TUBA1B, TUBA1A
3	cytoskeleton-dependent intracellular transport	GO:030705	8.7	TUBA1A, TUBB, TUBA1C, TUBA1B
4	mitotic cell cycle	GO:000278	8.7	TUBB, TUBA1A, CLIP1
5	microtubule-based process	GO:007017	8.7	TUBA1C, TUBA1B, TUBA1A, TUBB
6	protein polymerization	GO:051258	8.7	TUBA1B, TUBA1A, TUBA1C, TUBB
7	microtubule-based movement	GO:007018	8.6	TUBA1A, TUBA1B, TUBB, TUBA1C
8	cell division	GO:051301	8.5	TUBA1A, TUBA1C, TUBA1B, TUBB

Molecular functions related to distal hereditary motor neuropathy, type ii according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	8.6	TUBB, TUBA1B, TUBA1A, TUBA1C
2	GTPase activity	GO:003924	8.1	ARF3, TUBA1A, TUBA1B, TUBA1C, TUBB
3	GTP binding	GO:005525	7.9	TUBA1C, TUBA1B, TUBA1A, ARF3, TUBB