MCID: DST027
MIFTS: 20

Distal Hereditary Motor Neuropathy, Type Ii malady

Neuronal diseases category

Summaries for Distal Hereditary Motor Neuropathy, Type Ii

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MalaCards: Distal Hereditary Motor Neuropathy, Type Ii, also known as distal hereditary motor neuronopathy, type ii, is related to neuropathy and distal hereditary motor neuropathy. An important gene associated with Distal Hereditary Motor Neuropathy, Type Ii is HSPB8 (heat shock 22kDa protein 8), and among its related pathways are MHC class II antigen presentation and Chaperonin-mediated protein folding. The compounds albendazole and pironetin have been mentioned in the context of this disorder.

Aliases & Classifications for Distal Hereditary Motor Neuropathy, Type Ii

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21Genetics Home Reference
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Classifications:

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Anatomical: Neuronal diseases


Aliases & Descriptions:

distal hereditary motor neuropathy, type ii 21
distal hereditary motor neuronopathy, type ii 21


Related Diseases for Distal Hereditary Motor Neuropathy, Type Ii

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Distal Hereditary Motor Neuropathy, Type Ii:



Diseases related to distal hereditary motor neuropathy, type ii

Clinical Features for Distal Hereditary Motor Neuropathy, Type Ii

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Drugs & Therapeutics for Distal Hereditary Motor Neuropathy, Type Ii

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Distal Hereditary Motor Neuropathy, Type Ii

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Anatomical Context for Distal Hereditary Motor Neuropathy, Type Ii

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Animal Models for Distal Hereditary Motor Neuropathy, Type Ii or affiliated genes

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Publications for Distal Hereditary Motor Neuropathy, Type Ii

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Genetic Variations for Distal Hereditary Motor Neuropathy, Type Ii

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Expression for genes affiliated with Distal Hereditary Motor Neuropathy, Type Ii

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Distal Hereditary Motor Neuropathy, Type Ii

Search GEO for disease gene expression data for Distal Hereditary Motor Neuropathy, Type Ii.

Pathways for genes affiliated with Distal Hereditary Motor Neuropathy, Type Ii

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Distal Hereditary Motor Neuropathy, Type Ii according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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8.9TUBA1C, TUBA1A, TUBA1B
2
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8.9TUBA1C, TUBA1A, TUBA1B
3
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8.9TUBA1B, TUBA1A, TUBA1C
48.9TUBA1B, TUBA1A, TUBA1C
5
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8.9TUBA1C, TUBA1A, TUBA1B
6
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8.9TUBA1C, TUBA1A, TUBA1B
7
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8.9TUBA1B, TUBA1A, TUBA1C
8
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8.9TUBA1B, TUBA1A, TUBA1C
9
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8.9TUBA1C, TUBA1A, TUBA1B
10
Cytoskeleton remodeling Reverse signaling by ephrin B
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8.5TUBB, TUBA1B, TUBA1A, TUBA1C
118.5TUBB, TUBA1B, TUBA1A, TUBA1C
12
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8.5TUBB, TUBA1B, TUBA1A, TUBA1C
13
Cell adhesion Gap junctions
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8.5TUBB, TUBA1B, TUBA1A, TUBA1C
14
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
8.5TUBB, TUBA1B, TUBA1A, TUBA1C
15
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8.5TUBB, TUBA1B, TUBA1A, TUBA1C
16
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8.5TUBB, TUBA1B, TUBA1A, TUBA1C
178.5TUBB, TUBA1B, TUBA1A, TUBA1C
18
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8.5TUBA1C, TUBA1A, TUBA1B, TUBB
19
Cell cycle Spindle assembly and chromosome separation
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8.5TUBA1C, TUBA1A, TUBA1B, TUBB
20
Development Slit-Robo signaling
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8.5TUBA1C, TUBA1A, TUBA1B, TUBB
218.5TUBA1C, TUBA1A, TUBA1B, TUBB
228.4TUBB, TUBA1B, TUBA1A, CLIP1
23
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8.3CLIP1, TUBA1C, TUBA1A, TUBA1B
24
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8.3TUBA1B, TUBA1A, TUBA1C, CLIP1
25
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7.9TUBB, TUBA1B, TUBA1A, TUBA1C, CLIP1

Compounds for genes affiliated with Distal Hereditary Motor Neuropathy, Type Ii

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44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR
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Compounds related to Distal Hereditary Motor Neuropathy, Type Ii according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1albendazole44 1111.0TUBA1A, TUBB
2pironetin449.5TUBA1B, TUBB
3podophyllotoxin449.5TUBA1B, TUBB
4estramustine44 1110.3TUBA1B, TUBB
5rrna449.3TUBA1B, TUBB
6vinblastine44 49 1111.2TUBB, TUBA1B, TUBA1A
72-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE119.1TUBA1C, TUBA1A, TUBA1B
8cyanogen bromide449.0TUBA1B, TUBB
9Epothilone D118.8TUBA1C, TUBA1A, TUBA1B, TUBB
10vinorelbine ditartrate598.8TUBB, TUBA1B, TUBA1A, TUBA1C
11vinblastine sulfate598.8TUBB, TUBA1B, TUBA1A, TUBA1C
12epothilone b59 44 1110.8TUBB, TUBA1B, TUBA1A, TUBA1C
13gdp448.8TUBB, TUBA1B, ARF3
14nocodazole44 119.8TUBB, TUBA1B, CLIP1
15colchicine59 44 2 28 1112.8TUBB, TUBA1B, TUBA1A, TUBA1C
16docetaxel44 49 59 1111.8TUBB, TUBA1B, TUBA1A, TUBA1C
17gtp44 289.3CLIP1, ARF3, TUBA1B, TUBB

GO Terms for genes affiliated with Distal Hereditary Motor Neuropathy, Type Ii

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16Gene Ontology
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Cellular components related to Distal Hereditary Motor Neuropathy, Type Ii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic microtubuleGO:0058818.0TUBA1B, TUBA1A, TUBA1C, CLIP1
2microtubuleGO:0058747.9CLIP1, TUBA1C, TUBA1A, TUBA1B, TUBB
3microtubule cytoskeletonGO:0156307.8CLIP1, TUBA1C, TUBA1A, TUBA1B, TUBB

Biological processes related to Distal Hereditary Motor Neuropathy, Type Ii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein foldingGO:0064578.9TUBA1C, TUBA1A, TUBA1B
2de novo posttranslational protein foldingGO:0510848.8TUBA1C, TUBA1A, TUBA1B
3cytoskeleton-dependent intracellular transportGO:0307058.6TUBA1C, TUBA1A, TUBA1B, TUBB
4microtubule-based processGO:0070178.6TUBB, TUBA1B, TUBA1A, TUBA1C
5protein polymerizationGO:0512588.5TUBB, TUBA1B, TUBA1A, TUBA1C
6cell divisionGO:0513018.2TUBB, TUBA1B, TUBA1A, TUBA1C

Molecular functions related to Distal Hereditary Motor Neuropathy, Type Ii according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051988.5TUBA1C, TUBA1A, TUBA1B, TUBB
2structural constituent of cytoskeletonGO:0052008.4TUBB, TUBA1B, TUBA1A, TUBA1C
3GTPase activityGO:0039248.1ARF3, TUBA1C, TUBA1A, TUBA1B, TUBB
4GTP bindingGO:0055257.8TUBB, TUBA1B, TUBA1A, TUBA1C, ARF3

Products for genes affiliated with Distal Hereditary Motor Neuropathy, Type Ii

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Sources for Distal Hereditary Motor Neuropathy, Type Ii

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet