Distal Muscular Dystrophy malady

Wikipedia: Distal muscular dystrophy (or distal myopathy) is a group of disorders characterized by onset in the...⁴⁴ more...

MalaCards: Distal Muscular Dystrophy, also known as distal myopathies, is related to duchenne muscular dystrophy and becker muscular dystrophy. An important gene associated with Distal Muscular Dystrophy is DYSF (dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)), and among its related pathways are Striated Muscle Contraction and Viral myocarditis. The compounds succinate and hematoxylin have been mentioned in the context of this disorder. Related mouse phenotype muscle.

Aliases & Descriptions:

distal muscular dystrophy 6 8 32 distal myopathies 17 32 distal muscular dystrophy (disorder) 6 distal muscular dystrophies 43

muscular dystrophy, distal 6 miyoshi muscular dystrophy 6 muscular dystrophy 43 distal myopathy 6

Diseases related to distal muscular dystrophy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 246)

id	Related Disease	Score	Top Affiliating Genes
1	duchenne muscular dystrophy	38.1	CHKB, DMD
2	becker muscular dystrophy	37.5	DMD, CHKB
3	ullrich congenital muscular dystrophy	34.2	CHKB, DMD
4	myopathy	33.9	NGFR, DYSF, DMD, MYH3, CHKB
5	limb-girdle muscular dystrophy type 2i	32.9	DYSF, CHKB
6	muscular dystrophy	32.6	DYSF, DMD, CHKB
7	limb-girdle muscular dystrophy, type 2g	32.6	DYSF, DMD
8	limb-girdle muscular dystrophy type 2f	31.9	DYSF, DMD
9	sarcoglycanopathies	31.2	DYSF, DMD
10	dystrophinopathies	31.2	DMD, DYSF
11	myositis	31.2	CHKB, DMD, DYSF
12	miyoshi myopathy	29.9	DYSF, CHKB
13	neuropathy	29.3	DYSF, DMD, CHKB, NGFR
14	inclusion body myositis	28.8	CHKB, DYSF, NGFR
15	polymyositis	28.8	DMD, CHKB, DYSF
16	limb-girdle muscular dystrophy, type 2b	28.3	DYSF, DMD
17	calpainopathy	28.3	DYSF, DMD
18	limb-girdle muscular dystrophy	28.2	DMD, DYSF
19	myotonia	28.0	DMD, CHKB
20	protein s deficiency	27.9	DMD, DYSF
21	malignant hyperthermia	27.8	DMD, CHKB
22	dmd-associated dilated cardiomyopathy	27.0	DMD, CHKB, DYSF
23	cytoplasmic body myopathy	12.9	CHKB, DMD
24	congenital muscular dystrophy	12.9
25	gas gangrene	12.8	CHKB, DMD
26	idiopathic myopathy	12.8	CHKB, DYSF
27	rhabdomyolysis, cerivastatin-induced	12.8	CHKB, DMD
28	centronuclear myopathy	12.8	DMD, CHKB
29	myopathy congenital	12.5	CHKB, DYSF, DMD
30	neuromuscular disease	12.5	CHKB, DYSF, DMD
31	addison's disease	12.4	DMD, DYSF
32	glycogen storage disease	12.2	CHKB, DMD
33	amyotrophic lateral sclerosis	12.1	NGFR, CHKB, DMD
34	lateral sclerosis	12.0	NGFR, DMD, CHKB
35	myocarditis	12.0	CHKB, MYH3, DMD
36	seizures	12.0	DMD, NGFR, CHKB
37	emery-dreifuss muscular dystrophy	11.9
38	gonococcal synovitis	11.7	NGFR, DYSF, CHKB, DMD
39	oculopharyngeal muscular dystrophy	11.6
40	facioscapulohumeral muscular dystrophy	11.2
41	fukuyama type muscular dystrophy	10.0
42	fukuyama congenital muscular dystrophy	9.8
43	miyoshi muscular dystrophy 3	9.6
44	limb-girdle muscular dystrophy, type 2c	9.3
45	epidermolysis bullosa	9.2
46	muscular dystrophy, duchenne and becker type	9.2
47	limb-girdle muscular dystrophy type 2h	9.1
48	neuronitis	9.1
49	limb-girdle muscular dystrophy, type 1a	8.9
50	miyoshi muscular dystrophy 2	8.9

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to distal muscular dystrophy:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle phenotype	MP:0005369	8.6	CHKB, DYSF, DMD, NGFR

Articles related to distal muscular dystrophy:

id	Title	Authors	Year	Affiliating Genes
1	Early onset distal muscular dystrophy with normal dysferlin expression. (16310593)	Murakami N.... Nonaka I.	2005	DYSF
2	A patient with distal muscular dystrophy without mutations in dysferlin gene but with abnormal dysferlin localization in muscle fibers (15568488)	Hozumi I.... Nonaka I.	2004	DYSF
3	Late-onset distal muscular dystrophy affecting the posterior calves. (14506716)	Katz J.S.... Amato A.A.	2003	DYSF, CHKB
4	Genetic heterogeneity in Miyoshi-type distal muscular dystrophy. (9673985)	Linssen W.H.... Bolhuis P.A.	1998	EGID-100505381
5	Two patients with distal muscular dystrophy and autonomic nerve dysfunction. (8059932)	Tomoda A.... Higuchi I.	1994	NGFR
6	Autosomal recessive distal muscular dystrophy: normal expression of dystrophin, utrophin and dystrophin-associated proteins in muscle fibers. (7836950)	Yamanouchi Y.... Nonaka I.	1994	DMD

Genes related to distal muscular dystrophy according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	DYSF	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	11.0	Publications
2	CHKB	choline kinase beta	11.0	Publications
3	DMD	dystrophin	11.0	Publications
4	EGID-100505381	Miyoshi muscular dystrophy 2	11.0	Publications
5	MYH3	myosin, heavy chain 3, skeletal muscle, embryonic	11.0
6	NGFR	nerve growth factor receptor	11.0	Publications

Pathways related to distal muscular dystrophy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Striated Muscle Contraction38	9.1	DMD, MYH3
2	Viral myocarditis20	9.1	DMD, MYH3
3	Development MAG-dependent inhibition of neurite outgrowth10	9.0	NGFR, MYH3
4	Development_MAG-dependent inhibition of neurite outgrowth41	8.8	NGFR, MYH3

Compounds related to distal muscular dystrophy according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	succinate32	9.5	CHKB, DMD
2	hematoxylin32	9.5	DMD, NGFR
3	peroxynitrite32	9.2	CHKB, NGFR
4	polyacrylamide32	9.1	CHKB, DMD, NGFR
5	creatinine32	9.0	DMD, DYSF, CHKB
6	leucine32	9.0	CHKB, DMD, NGFR

Biological processes related to distal muscular dystrophy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle organ development	GO:007517	9.1	DMD, MYH3
2	muscle filament sliding	GO:030049	8.8	DMD, MYH3