MCID: DSS006
MIFTS: 25

Disuse Amblyopia

Categories: Eye diseases

Aliases & Classifications for Disuse Amblyopia

MalaCards integrated aliases for Disuse Amblyopia:

Name: Disuse Amblyopia 12 14
Stimulus Deprivation Amblyopia 69
Deprivation Amblyopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10378
ICD10 33 H53.01
ICD9CM 35 368.02
SNOMED-CT 64 193638002 21457000
UMLS 69 C0152189

Summaries for Disuse Amblyopia

MalaCards based summary : Disuse Amblyopia, also known as stimulus deprivation amblyopia, is related to amyotrophic neuralgia and femoral vein thrombophlebitis. An important gene associated with Disuse Amblyopia is PLXNA2 (Plexin A2), and among its related pathways/superpathways are Ectoderm Differentiation and Hedgehog Pathway. Affiliated tissues include eye, and related phenotypes are behavior/neurological and cellular

Related Diseases for Disuse Amblyopia

Graphical network of the top 20 diseases related to Disuse Amblyopia:



Diseases related to Disuse Amblyopia

Symptoms & Phenotypes for Disuse Amblyopia

MGI Mouse Phenotypes related to Disuse Amblyopia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ATP7B CADM1 CHN1 CSAD FGF13 FGF2
2 cellular MP:0005384 10.18 FOS FOXA2 GLI2 GRM1 PLXNA2 SHH
3 growth/size/body region MP:0005378 10.11 CADM1 CHN1 DPT FOS FOXA2 GLI2
4 nervous system MP:0003631 10.1 FGF13 FGF2 FOS FOXA2 GLI2 GRM1
5 reproductive system MP:0005389 9.81 SHH ATP7B CADM1 CSAD FGF2 FOS
6 neoplasm MP:0002006 9.8 EPHA2 FGF2 FOS FOXA2 GRM1 SHH
7 skeleton MP:0005390 9.56 CHN1 EPHA2 FGF2 FOS FOXA2 GLI2
8 vision/eye MP:0005391 9.28 DPT EPHA2 FGF2 FOS FOXA2 GLI2

Drugs & Therapeutics for Disuse Amblyopia

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effectiveness of Telescopic Magnification in the Treatment of Amblyopia Completed NCT00970554 Phase 1, Phase 2

Search NIH Clinical Center for Disuse Amblyopia

Genetic Tests for Disuse Amblyopia

Anatomical Context for Disuse Amblyopia

MalaCards organs/tissues related to Disuse Amblyopia:

39
Eye

Publications for Disuse Amblyopia

Variations for Disuse Amblyopia

Expression for Disuse Amblyopia

Search GEO for disease gene expression data for Disuse Amblyopia.

Pathways for Disuse Amblyopia

GO Terms for Disuse Amblyopia

Biological processes related to Disuse Amblyopia according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.92 FGF2 FOS FOXA2 GLI2 SHH
2 ephrin receptor signaling pathway GO:0048013 9.61 CHN1 EPHA2 SDCBP
3 dopaminergic neuron differentiation GO:0071542 9.59 FOXA2 SHH
4 hindbrain development GO:0030902 9.58 GLI2 SHH
5 spinal cord motor neuron differentiation GO:0021522 9.57 GLI2 SHH
6 anatomical structure formation involved in morphogenesis GO:0048646 9.56 GLI2 SHH
7 osteoblast development GO:0002076 9.55 GLI2 SHH
8 cell fate specification GO:0001708 9.54 FOXA2 SHH
9 anatomical structure development GO:0048856 9.49 GLI2 SHH
10 embryonic morphogenesis GO:0048598 9.48 FGF2 SHH
11 dorsal/ventral neural tube patterning GO:0021904 9.46 GLI2 SHH
12 neural tube development GO:0021915 9.43 EPHA2 GLI2 PLXNA2
13 limb bud formation GO:0060174 9.4 PLXNA2 SHH
14 positive regulation of T cell differentiation in thymus GO:0033089 9.37 GLI2 SHH
15 spinal cord dorsal/ventral patterning GO:0021513 9.32 GLI2 SHH
16 prostate gland development GO:0030850 9.21 SHH
17 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.16 GLI2 SHH
18 hindgut morphogenesis GO:0007442 8.96 GLI2 SHH
19 ventral midline development GO:0007418 8.62 GLI2 SHH
20 multicellular organism development GO:0007275 10.06 CADM1 EPHA2 FGF2 FOXA2 GLI2 SHH

Sources for Disuse Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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