MCID: DVR002
MIFTS: 49

Diverticulitis malady

Gastrointestinal diseases category
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Summaries for Diverticulitis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Diverticulitis is a common digestive disease which involves the formation of pouches (diverticula)... more...

MalaCards: Diverticulitis, also known as diverticulitis unspecified, is related to colorectal cancer and aneurysm. An important gene associated with Diverticulitis is MMP13 (matrix metallopeptidase 13 (collagenase 3)), and among its related pathways are Selected targets of HNF1 and AGE/RAGE pathway. The drugs scopolamine and scopolamine hydrobromide and the compounds (4-aminophenyl)mercuric acetate and uk 383367 have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and heart.

Aliases & Classifications for Diverticulitis

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

diverticulitis 8 10 45 62
diverticulitis unspecified 8
diverticulitis nos 8


External Ids:

Disease Ontology8 DOID:7475
NCIt40 C26752
MeSH35 D004238

Related Diseases for Diverticulitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Diverticulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer30.2SERPINA1, MUC5AC, MMP13, MMP9
2aneurysm30.1SERPINA1, MMP9
3lung cancer30.0MMP9, MMP13, MUC5AC, SERPINA1
4inflammatory bowel disease30.0SERPINA1, MUC5AC, MMP13, CRP
5aortic aneurysm29.9CRP
6abdominal aortic aneurysm29.9MMP9, MMP13
7meningitis29.8MMP9, CRP
8ulcerative colitis29.8SERPINA1, MMP13, CRP
9arthritis29.8CRP, MMP9, MMP13
10meckel's diverticulitis10.7
11appendicitis10.5
12peritonitis10.5
13diverticulitis of colon10.4
14duodenitis10.3
15colon cancer10.2
16thrombophlebitis10.2
17necrotizing fasciitis10.2
18fasciitis10.2
19obesity10.2
20small intestine diverticulitis10.1
21williams syndrome10.1
22wegener's granulomatosis10.1SERPINA1
23corneal ulcer10.1MUC5AC
24pulmonary emphysema10.1MMP9, SERPINA1
25eye disease10.1SERPINA1, MUC5AC
26bone carcinoma10.1MMP13, MMP9
27periodontitis10.0MMP9, MMP13
28crohn's disease10.0
29williams-beuren syndrome10.0
30polycystic kidney disease10.0
31irritable bowel syndrome10.0
32endocarditis10.0
33hepatitis10.0
34kidney disease10.0
35schistosomiasis10.0
36ileus10.0
37blindness10.0
38epididymitis10.0
39synovitis10.0CRP, MMP13
40viral meningitis10.0CRP, SERPINA1
41bronchitis10.0CRP, SERPINA1
42ankylosing spondylitis10.0SERPINA1, CRP
43respiratory failure10.0CRP, SERPINA1
44pancreatitis, chronic10.0MUC5AC, SERPINA1
45arthropathy10.0CRP, MMP13
46carotid stenosis10.0CRP, MMP9
47cork-handlers' disease10.0SERPINA1, MUC5AC, MMP9
48kawasaki disease10.0CRP, MMP9
49lung adenocarcinoma10.0SERPINA1, MUC5AC, MMP9
50acute pancreatitis10.0CRP, SERPINA1

Graphical network of the top 20 diseases related to Diverticulitis:



Diseases related to diverticulitis

Symptoms for Diverticulitis

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Drugs & Therapeutics for Diverticulitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Diverticulitis

Search NIH Clinical Center for Diverticulitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Diverticulitis

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Anatomical Context for Diverticulitis

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33MalaCards
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MalaCards organs/tissues related to Diverticulitis:

33
Colon, Small intestine, Heart, Liver, Lung, Kidney, Breast, Prostate, Testes, Appendix

Animal Models for Diverticulitis or affiliated genes

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Publications for Diverticulitis

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Sources:
52PubMed
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Articles related to Diverticulitis:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Rifaximin plus fibre versus fibre alone in preventing diverticulitis recurrence: a (problematic) trial to tackle an epidemiologically relevant problem. (23298762)
2013
2
The role of abdominal imaging in cases with a high probability of acute left-sided colonic diverticulitis based on a clinical scoring system. (23774316)
2013
3
Laparoscopic versus open Hartmann procedure for the emergency treatment of diverticulitis: a propensity-matched analysis. (23222283)
2013
4
Nonoperative management of complicated diverticulitis with extradigestive air. (23711261)
2013
5
Detection of endoscopic and histological inflammation after an attack of colonic diverticulitis is associated with higher diverticulitis recurrence. (23539385)
2013
6
Position paper: management of perforated sigmoid diverticulitis. (24369826)
2013
7
Re: Mandatory exploration is not necessary for patients with acute diverticulitis and free intraperitoneal air. (23609295)
2013
8
Acute sigmoid diverticulitis within an incarcerated inguinal hernia in an adult: a first report. (23574826)
2013
9
Perforated diverticulitis with fistula mimicking an inguinal hernia. (23336644)
2013
10
Suspected left sided diverticulitis. (23447355)
2013
11
Small bowel diverticulitis masquerading as Crohn's disease. (23815990)
2013
12
Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis-a prospective randomized study. (24343275)
2013
13
Colonoscopy after CT diagnosis of diverticulitis to exclude colon cancer: a systematic literature review. (22517956)
2012
14
Laparoscopic lavage for perforated diverticulitis: a population analysis. (22874599)
2012
15
Stercoral colonic diverticulum perforation with jejunal diverticulitis mimicking upper gastrointestinal perforation. (22490417)
2012
16
Colouterine fistula caused by diverticulitis of the sigmoid colon. (23346512)
2012
17
Cecal diverticulitis as a continuing diagnostic and management dilemma: a report of two cases in children. (22138978)
2012
18
Routine colonoscopy following acute uncomplicated diverticulitis. (21713756)
2011
19
Correlation between complicated diverticulitis and visceral fat. (22022188)
2011
20
How complicated is complicated diverticulitis?--phlegmonous diverticulitis revisited. (21830036)
2011
21
Co-morbidity and postsurgical outcome in patients with perforated sigmoid diverticulitis. (20676663)
2011
22
Older patients with diverticulitis have low recurrence rates and rarely need surgery. (21801956)
2011
23
Long-term follow-up after an initial episode of diverticulitis: what are the predictors of recurrence? (21304297)
2011
24
Cyclical increase in diverticulitis during the summer months. (21422363)
2011
25
Therapy of solitary cecal diverticulitis in a young patient with laparoscopic right hemicolectomy. (21857454)
2011
26
A case of colitis cystica profunda in association with diverticulitis. (21212765)
2011
27
Perforated left-sided diverticulitis with faecal peritonitis: is the Hinchey classification the best guide for surgical decision making? (21271350)
2011
28
Complicated sigmoid diverticulitis--Hartmann's procedure or primary anastomosis? (22299325)
2011
29
Acute scrotum caused by sigmoid diverticulitis. (22142315)
2011
30
Differential association of race with treatment and outcomes in Medicare patients undergoing diverticulitis surgery. (22106319)
2011
31
Spectrum of disease and outcome among patients with acute diverticulitis. (20571265)
2010
32
Prospective randomized trial comparing short-term antibiotic therapy versus standard therapy for acute uncomplicated sigmoid diverticulitis. (20140619)
2010
33
Colovesical, coloenteric, colocutaneous fistula, and hip septic arthritis secondary to sigmoid diverticulitis. (20012298)
2010
34
Treatment of right colonic diverticulitis: the role of nonoperative treatment. (21221240)
2010
35
Outpatient treatment of patients with uncomplicated acute diverticulitis. (19906059)
2010
36
Colonic diverticulitis in the neck: a late complication of laryngopharyngectomy surgery. (20573308)
2010
37
Nonreversal of Hartmann's procedure for diverticulitis: derivation of a scoring system to predict nonreversal. (19617751)
2009
38
Small bowel diverticulitis as a cause of acute abdomen. (19011578)
2009
39
Prospective evaluation of the value of magnetic resonance imaging in suspected acute sigmoid diverticulitis. (19502884)
2009
40
Colonic diverticulitis in adolescents: an index case and associated syndromes. (19711089)
2009
41
Diverticulosis and diverticulitis. (19186323)
2008
42
Acute ulcerative jejunal diverticulitis: case report of an uncommon entity. (18985822)
2008
43
Sigmoid diverticulitis in patients with Williams-Beuren syndrome: relatively high prevalence and high complication rate in young adults with the syndrome. (16007633)
2005
44
Abdominal computerized tomography in the diagnosis of Meckel's diverticulitis in the adult. (11794933)
2001
45
Perforation of acute calculous Meckel's diverticulitis: a rare cause of acute abdomen in elderly. (11143326)
2000
46
Soft-tissue images. Meckel's diverticulitis. (10372008)
1999
47
Intestinal perforation by saline total gut lavage in occult diverticulitis. (9826157)
1998
48
Septic thrombophlebitis of the inferior mesenteric vein associated with diverticulitis CT diagnosis. (8744820)
1996
49
Surgical management in complications of diverticulitis of colon. (13661559)
1959
50
Neurilemmoma of the sigmoid colon, associated with diverticulitis as a cause of obstruction. (14388189)
1955

Variations for Diverticulitis

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Expression for genes affiliated with Diverticulitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diverticulitis

Search GEO for disease gene expression data for Diverticulitis.

Pathways for genes affiliated with Diverticulitis

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Sources:
50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome
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Pathways related to Diverticulitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRP, SERPINA1
29.8MMP9, MMP13
3
Show member pathways
9.8MMP9, MMP13
49.8MMP9, MMP13

Compounds for genes affiliated with Diverticulitis

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Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Diverticulitis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate4510.1MMP9, MMP13
2uk 3833676110.1MMP13, MMP9
3gi 254023x6110.1MMP13, MMP9
4gm 60016110.1MMP13, MMP9
5hydroxamate4510.1MMP9, MMP13
6fosinopril45 1111.1MMP9, CRP
7marimastat45 61 1112.1MMP9, MMP13
8gabexate mesilate4510.1CRP, MMP9
9batimastat45 61 1112.0MMP9, MMP13
108-isoprostane4510.0CRP, MMP9
11alpha lipoic acid459.9MMP9, SERPINA1
12hydroxyproline45 24 1111.9MMP9, MMP13
13fenofibrate45 51 1111.9MMP9, CRP
14ivig459.8CRP, MMP9
15p002459.8CRP, MMP9, MMP13
16ascorbic acid45 2410.8SERPINA1, MMP13, CRP
17doxycycline45 1110.8MMP9, MMP13
18vitamin a45 24 1111.7CRP, MMP9, SERPINA1
19pioglitazone29 45 51 1112.7CRP, MMP9
20fluvastatin45 51 29 1112.6CRP, MMP9
21fibrinogen459.5SERPINA1, MMP13, MMP9, CRP
22prostaglandin459.3MUC5AC, MMP13, MMP9
23ribonucleic acid459.3MUC5AC, MMP13, MMP9
24methotrexate51 45 1111.2MUC5AC, MMP9, CRP
25pd 98,059459.2MMP9, MMP13, MUC5AC
26n acetylcysteine459.2CRP, MMP9, MUC5AC
27paraffin459.0SERPINA1, MUC5AC, MMP13, MMP9
28pge2459.0MUC5AC, MMP13, MMP9
29sb 20358045 6110.0CRP, MMP9, MMP13, MUC5AC
30hematoxylin458.9MMP9, MUC5AC
31estrogen458.9SERPINA1, MUC5AC, MMP13, MMP9
32cysteine458.8SERPINA1, MUC5AC, MMP13, MMP9
33serine458.6SERPINA1, MUC5AC, MMP13, MMP9, ACADS

GO Terms for genes affiliated with Diverticulitis

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16Gene Ontology
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Cellular components related to Diverticulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.1SERPINA1, MMP13, MMP9
2extracellular spaceGO:0056159.1CRP, MMP9, MMP13, SERPINA1
3extracellular regionGO:0055767.9CRP, MMP9, MMP13, SERPINA1, APOLD1, TNFRSF18

Biological processes related to Diverticulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lead ionGO:0102889.8CRP, SERPINA1
2collagen catabolic processGO:0305749.8MMP9, MMP13
3acute-phase responseGO:0069539.5CRP, SERPINA1
4response to hypoxiaGO:0016669.2CRP, SERPINA1, APOLD1

Products for genes affiliated with Diverticulitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Diverticulitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet