MCID: DVR002
MIFTS: 45

Diverticulitis malady

Summaries for Diverticulitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Diverticulitis is a common digestive disease which involves the formation of pouches (diverticula)... more...

MalaCards: Diverticulitis, also known as diverticulitis unspecified, is related to colorectal cancer and inflammatory bowel disease. An important gene associated with Diverticulitis is MMP13 (matrix metallopeptidase 13 (collagenase 3)). The drugs scopolamine and scopolamine hydrobromide and the compounds fosinopril and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver.

Aliases & Classifications for Diverticulitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

diverticulitis 8 10 44 60
diverticulitis unspecified 8
diverticulitis nos 8


External Ids:

Disease Ontology8 DOID:7475
NCIt39 C26752
MeSH34 D004238

Related Diseases for Diverticulitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Diverticulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer30.1SERPINA1, MMP9, MMP13, MUC5AC
2inflammatory bowel disease29.9CRP, MUC5AC, MMP13, SERPINA1
3ulcerative colitis29.7CRP
4abdominal aortic aneurysm29.7MMP13, MMP9
5diverticulitis of colon10.8
6meckel's diverticulitis10.7
7appendicitis10.5
8peritonitis10.5
9colonic disease10.4
10colon cancer10.3
11duodenitis10.2
12obesity10.2
13thrombophlebitis10.2
14necrotizing fasciitis10.1
15fasciitis10.1
16williams syndrome10.1
17sigmoid disease10.1
18small intestine diverticulitis10.1
19crohn's disease10.0
20colon lymphoma10.0
21williams-beuren syndrome10.0
22morbid obesity10.0
23polycystic kidney disease10.0
24irritable bowel syndrome10.0
25endocarditis10.0
26hepatitis10.0
27kidney disease10.0
28lung cancer10.0
29schistosomiasis10.0
30liver cirrhosis10.0SERPINA1
31wegener's granulomatosis10.0SERPINA1
32rectal prolapse10.0APOLD1
33corneal ulcer10.0MUC5AC
34otitis media10.0MUC5AC
35proctitis10.0APOLD1
36pulmonary fibrosis10.0MMP9, MMP13
37synovitis10.0CRP, MMP13
38viral meningitis10.0CRP, SERPINA1
39eye disease10.0CRP
40bronchitis10.0CRP, SERPINA1
41kawasaki disease10.0CRP, MMP9
42periodontal disease10.0CRP, MMP9, MMP13
43pulmonary disease, chronic obstructive10.0CRP, MMP9, SERPINA1
44stomach cancer10.0SERPINA1, MMP9, MMP13, MUC5AC
45burns9.8
46paralytic ileus9.8
47perivascular epithelioid cell tumor9.8
48toxic megacolon9.8
49neuroendocrine carcinoma9.8
50cutis laxa9.8

Graphical network of the top 20 diseases related to Diverticulitis:



Diseases related to diverticulitis

Clinical Features for Diverticulitis

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Drugs & Therapeutics for Diverticulitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Diverticulitis

Drug clinical trials:

Search ClinicalTrials for Diverticulitis

Search NIH Clinical Center for Diverticulitis

Search CenterWatch for Diverticulitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Diverticulitis

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Anatomical Context for Diverticulitis

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32MalaCards
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MalaCards organs/tissues related to Diverticulitis:

32
Colon, Small intestine, Liver, Heart, Kidney, Lung, Testes, Prostate, Breast, Appendix

Animal Models for Diverticulitis or affiliated genes

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Publications for Diverticulitis

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Sources:
50PubMed
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Articles related to Diverticulitis:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Surgery for Diverticulitis in the 21st Century: A Systematic Review. (24430164)
2014
2
The role of abdominal imaging in cases with a high probability of acute left-sided colonic diverticulitis based on a clinical scoring system. (23774316)
2013
3
Perforated diverticulitis with fistula mimicking an inguinal hernia. (23336644)
2013
4
Diverticulitis of multiple diverticulosis of the terminal ileum. (23411586)
2013
5
Emergency surgery for acute diverticulitis: which operation? A National Surgical Quality Improvement Program study. (23694862)
2013
6
Coexistence of Behcet's disease and colonic diverticulitis: is it causal or just a coincidence? (23794349)
2013
7
A common cause of irritable bowel syndrome and diverticulitis: chronic distal colon distention from sedentary behavior and excessive dietary fiber. (23899281)
2013
8
A confusing case: pulmonary lesions including cavities, isolated left heart endocarditis and inferior vena cava thrombosis in a patient with perforated diverticulitis. (22453530)
2013
9
External validation of two tools for the clinical diagnosis of acute diverticulitis without imaging. (24252579)
2013
10
Why Symptoms Persists Following Acute Diverticulitis? (24362050)
2013
11
Is early colonoscopy beneficial in patients with CT-diagnosed diverticulitis? (23701063)
2013
12
Colonoscopy after CT diagnosis of diverticulitis to exclude colon cancer: a systematic literature review. (22517956)
2012
13
Racial differences in short-term surgical outcomes following surgery for diverticulitis. (22125173)
2012
14
Current status of the treatment of acute colonic diverticulitis: a systematic review. (21848896)
2012
15
Age and immunocompromised status in acute diverticulitis. (22958750)
2012
16
Western Trauma Association critical decisions in trauma: management of complicated diverticulitis. (23188229)
2012
17
Uncomplicated diverticulitis, more complicated than we thought. (22696233)
2012
18
Small cell lung cancer metastasizing to the colon in a colovesicular fistula in the setting of diverticulitis. (22546106)
2012
19
Letter 1: Routine colonoscopy following acute uncomplicated diverticulitis (Br J Surg 2011; 98: 1630-1634). (22222807)
2012
20
Difficulty in differentiating two cases of sigmoid stenosis by diverticulitis from cancer. (22826630)
2012
21
A case of colitis cystica profunda in association with diverticulitis. (21212765)
2011
22
Epidemiological similarities between appendicitis and diverticulitis suggesting a common underlying pathogenesis. (21422362)
2011
23
Outcomes of laparoscopic versus open colectomy in elective surgery for diverticulitis. (21732208)
2011
24
Time for a (re) definition of (recurrent) sigmoid diverticulitis? (22041512)
2011
25
Is colonoscopy still mandatory after a CT diagnosis of left-sided diverticulitis: can colorectal cancer be confidently excluded? (21904141)
2011
26
Tuboovarian abscess as unusual presentation of tubarian fistula secondary to sigmoid diverticulitis. (21619391)
2011
27
Colovesical, coloenteric, colocutaneous fistula, and hip septic arthritis secondary to sigmoid diverticulitis. (20012298)
2010
28
Commentary: Perspectives on diverticulitis and the art of clinical science - treat the man not the scan. (20447191)
2010
29
Use of severity classification systems in the surgical decision-making process in emergency laparotomy for perforated diverticulitis. (20091171)
2010
30
Cologenital fistula secondary to diverticulitis. (20039780)
2010
31
Small intestinal diverticulitis. (20621201)
2010
32
Current indications and role of surgery in the management of sigmoid diverticulitis. (20143459)
2010
33
Treatment of perforated diverticulitis with generalized peritonitis: past, present, and future. (20052468)
2010
34
Primary anastomosis vs Hartmann's procedure in patients undergoing emergency left colectomy for perforated diverticulitis. (19175638)
2010
35
Elderly patient with acute, left lower abdominal pain: perforated jejunal diverticulitis (2010:7b). (20845020)
2010
36
Small bowel diverticulitis as a cause of acute abdomen. (19011578)
2009
37
Left sided diverticulitis presenting as a right lumbar fistula: a case report. (19918511)
2009
38
Acute complicated diverticulitis managed by laparoscopic lavage. (19571714)
2009
39
Antimicrobial therapy for acute colonic diverticulitis. (19226204)
2009
40
Penetration of the sigmoid colon to the posterior uterine wall secondary to diverticulitis: a case report. (20727222)
2009
41
Diverticulitis. (19069700)
2008
42
Diverticulitis in immunosuppressed patients. (18936657)
2008
43
Pylephlebitis and mesenteric thrombophlebitis in sigmoid diverticulitis: medical approach, delayed surgery. (17644055)
2007
44
Meckel's diverticulitis: a rare etiology of an acute abdomen during pregnancy. (16843783)
2006
45
CT of Meckel's diverticulitis in 11 patients. (14975960)
2004
46
Meckel's diverticulitis: an uncommon complication during pregnancy. (11762664)
2001
47
Meckel's diverticulitis associated with Schistosoma mansoni. (10067741)
1999
48
Meckel's diverticulitis due to schistosomiasis mansoni. (13520682)
1958
49
Surgical treatment of diverticulitis of colon. (13227745)
1955
50
Acute Meckel's diverticulitis with round worms in the peritoneal cavity. (13016899)
1953

Genetic Variations for Diverticulitis

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Expression for genes affiliated with Diverticulitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diverticulitis

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Pathways for genes affiliated with Diverticulitis

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Compounds for genes affiliated with Diverticulitis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Diverticulitis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1fosinopril44 1111.1MMP9, CRP
2(4-aminophenyl)mercuric acetate4410.1MMP13, MMP9
3gabexate mesilate4410.1CRP, MMP9
4gm 60015910.0MMP13, MMP9
5uk 383367599.9MMP9, MMP13
6p002449.8MMP13, CRP, MMP9
7ascorbic acid44 2410.8PLOD2, CRP, SERPINA1, MMP13
8fibrinogen449.7SERPINA1, MMP9, MMP13, CRP
9gi 254023x599.7MMP13, MMP9
10sb 20358044 5910.1MMP13, MMP9, MUC5AC, CRP
11paraffin448.9SERPINA1, MUC5AC, MMP13, MMP9

GO Terms for genes affiliated with Diverticulitis

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16Gene Ontology
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Biological processes related to Diverticulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lead ionGO:01028810.0SERPINA1, CRP
2response to hypoxiaGO:0016668.8SERPINA1, PLOD2, CRP, APOLD1

Products for genes affiliated with Diverticulitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Diverticulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet