MCID: DVR002
MIFTS: 39

Diverticulitis malady

Summaries for Diverticulitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Diverticulitis is a common digestive disease which involves the formation of pouches (diverticula)... more...

MalaCards: Diverticulitis, also known as diverticulitis unspecified, is related to colorectal cancer and ulcerative colitis. An important gene associated with Diverticulitis is MMP13 (matrix metallopeptidase 13 (collagenase 3)). The drugs scopolamine and scopolamine hydrobromide and the compounds fosinopril and (4-aminophenyl)mercuric acetate have been mentioned in the context of this disorder.

Aliases & Classifications for Diverticulitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

diverticulitis 8 10 45 61
diverticulitis unspecified 8
diverticulitis nos 8


External Ids:

Disease Ontology8 DOID:7475
NCIt40 C26752
MeSH35 D004238

Related Diseases for Diverticulitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Diverticulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer30.1SERPINA1, MMP9, MMP13, MUC5AC
2ulcerative colitis29.8CRP
3abdominal aortic aneurysm29.8MMP13, MMP9
4pulmonary disease, chronic obstructive29.8SERPINA1, MMP9, CRP
5appendicitis10.6
6meckel's diverticulitis10.5
7thrombophlebitis10.2
8necrotizing fasciitis10.2
9williams syndrome10.2
10sigmoid disease10.1
11diverticulitis of colon10.1
12colon lymphoma10.0
13williams-beuren syndrome10.0
14small intestine diverticulitis10.0
15morbid obesity10.0
16polycystic kidney disease10.0
17irritable bowel syndrome10.0
18young syndrome10.0
19epididymitis10.0
20ileus10.0
21liver cirrhosis10.0SERPINA1
22wegener's granulomatosis10.0SERPINA1
23rectal prolapse10.0APOLD1
24corneal ulcer10.0MUC5AC
25otitis media10.0MUC5AC
26proctitis10.0APOLD1
27pulmonary fibrosis10.0MMP9, MMP13
28synovitis10.0MMP13, CRP
29viral meningitis10.0SERPINA1, CRP
30eye disease10.0CRP
31bronchitis10.0CRP, SERPINA1
32kawasaki disease10.0MMP9, CRP
33periodontal disease10.0MMP9, MMP13, CRP
34inflammatory bowel disease10.0CRP, MUC5AC, MMP13, SERPINA1
35stomach cancer10.0SERPINA1, MMP9, MMP13, MUC5AC
36burns9.9
37crohn's disease9.9
38paralytic ileus9.9
39perivascular epithelioid cell tumor9.9
40toxic megacolon9.9
41neuroendocrine carcinoma9.9
42cutis laxa9.9
43xanthogranulomatous pyelonephritis9.9
44intracranial abscess9.9
45cellulitis9.9
46intussusception9.9
47ruptured abdominal aortic aneurysm9.9
48situs inversus9.9
49septic arthritis9.9
50cauda equina syndrome9.9

Graphical network of the top 20 diseases related to Diverticulitis:



Diseases related to diverticulitis

Clinical Features for Diverticulitis

Drugs & Therapeutics for Diverticulitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Diverticulitis

Drug clinical trials:

Search ClinicalTrials for Diverticulitis

Search NIH Clinical Center for Diverticulitis

Search CenterWatch for Diverticulitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Diverticulitis

Anatomical Context for Diverticulitis

Animal Models for Diverticulitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Diverticulitis

Sources:
51PubMed
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Articles related to Diverticulitis:

(show top 50)    (show all 562)
idTitleAuthorsYear
1
Detection of endoscopic and histological inflammation after an attack of colonic diverticulitis is associated with higher diverticulitis recurrence. (23539385)
2013
2
Appendiceal diverticulitis in a femoral hernia causing necrotizing fasciitis of the right inguinal region: report of a unique case. (21541716)
2013
3
A vaginal drain of a pelvic abscess due to colonic diverticulitis. (24303472)
2013
4
Cauda equina syndrome secondary to complicated diverticulitis. (24403885)
2013
5
The value of inflammation markers and body temperature in acute diverticulitis. (23088216)
2013
6
Colon cancer after acute diverticulitis treatment. (24032118)
2013
7
Colovesical fistula in sigmoid diverticulitis A case report. (23917777)
2013
8
Differential diagnosis of left-sided abdominal pain: primary epiploic appendagitis vs colonic diverticulitis. (24187459)
2013
9
Appendicitis/diverticulitis: minimally invasive surgery. (23797127)
2013
10
Two cases of Ruminococcus gnavus bacteremia associated with diverticulitis. (23363832)
2013
11
Laparoscopic lavage for perforated diverticulitis: a population analysis. (22874599)
2012
12
Surgical treatment of acute recurrent diverticulitis: early elective or late elective surgery. An analysis of 237 patients. (22311143)
2012
13
Perianal abscess and sigmoidocutaneous fistula due to diverticulitis. (22369795)
2012
14
Ileal diverticulitis complicated by portal-mesenteric pylephlebitis and pulmonary septic foci. (22277712)
2012
15
Antibiotics for uncomplicated diverticulitis. (23152268)
2012
16
Sonographic findings of Meckel's diverticulitis. (22764670)
2012
17
Recurrent Urinary Tract Infections due to Asymptomatic Colonic Diverticulitis. (22454651)
2012
18
Colonoscopy in acute diverticulitis: when and why. (22495814)
2012
19
Therapy of solitary cecal diverticulitis in a young patient with laparoscopic right hemicolectomy. (21857454)
2011
20
Differential association of race with treatment and outcomes in Medicare patients undergoing diverticulitis surgery. (22106319)
2011
21
Controversies in the diagnosis and management of diverticulitis coli. (21767144)
2011
22
Enterolith ileus: liberated large jejunal diverticulum enterolith causing small bowel obstruction in the setting of jejunal diverticulitis. (21750131)
2011
23
Bladder diverticulitis: a case report. (23326691)
2011
24
A case of colovesical fistula induced by sigmoid diverticulitis. (21602969)
2011
25
Laparoscopic one-stage resection of right and left colon complicated diverticulitis equivalent to Hinchey stage I-II. (21533936)
2011
26
Perforated diverticulitis operated at Sahlgrenska University Hospital 2003-2008. (21205561)
2011
27
Long-term outcome after conservative and surgical treatment of acute sigmoid diverticulitis. (21688045)
2011
28
Impact of early or delayed elective resection in complicated diverticulitis. (22219596)
2011
29
Sigmoid diverticulitis in young patients--a more aggressive disease than in older patients? (21318443)
2011
30
Nervous system abscess: a rare complication of diverticulitis. (21819523)
2011
31
Spectrum of disease and outcome among patients with acute diverticulitis. (20571265)
2010
32
Diverticulitis in transplant patients and patients on chronic corticosteroid therapy: a systematic review. (21178867)
2010
33
You're the flight surgeon: diverticulitis. (20058745)
2010
34
Acute appendicitis and cecal diverticulitis in a young woman. (20534057)
2010
35
Pathophysiology and prevention of diverticulitis and perforation. (21071775)
2010
36
Microscopic findings in sigmoid diverticulitis--changes after conservative therapy. (20186500)
2010
37
Giant Meckel's diverticulitis: a rare condition complicating pregnancy. (20409519)
2010
38
Laparoscopic peritoneal lavage for perforated colonic diverticulitis: a systematic review. (19788490)
2010
39
A clinical decision rule to establish the diagnosis of acute diverticulitis at the emergency department. (20485003)
2010
40
Damage control with abdominal vacuum therapy (VAC) to manage perforated diverticulitis with advanced generalized peritonitis--a proof of concept. (20148255)
2010
41
Randomized controlled trial of oral vs intravenous therapy for the clinically diagnosed acute uncomplicated diverticulitis. (19016815)
2009
42
Diverticulosis and diverticulitis of the appendix. (19233860)
2009
43
Diverticulosis and acute diverticulitis. (19699411)
2009
44
Laparoscopic treatment in acute complicated diverticulitis: a review of 11 cases. (19341197)
2009
45
Outcome and prognostic factors of morbidity and mortality in perforated sigmoid diverticulitis. (20187519)
2009
46
Bacterial meningitis and sigmoid diverticulitis caused by Listeria monocytogenes. (18751639)
2008
47
Perforation of an inguinoscrotal Littre's hernia due to Meckel's diverticulitis: an unusual cause of acute hemiscrotum. (16449036)
2006
48
Laparoscopic surgery in situs inversus: a literature review and a report of laparoscopic sigmoidectomy for diverticulitis in situs inversus. (15243744)
2004
49
Abdominal computerized tomography in the diagnosis of Meckel's diverticulitis in the adult. (11794933)
2001
50
Lymphopenia in diverticulitis. (1678819)
1991

Genetic Variations for Diverticulitis

Expression for genes affiliated with Diverticulitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Diverticulitis

Search GEO for disease gene expression data for Diverticulitis.

Pathways for genes affiliated with Diverticulitis

Compounds for genes affiliated with Diverticulitis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Diverticulitis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1fosinopril45 1111.1MMP9, CRP
2(4-aminophenyl)mercuric acetate4510.1MMP9, MMP13
3gabexate mesilate4510.1CRP, MMP9
4uk 3833676010.0MMP9, MMP13
5gm 6001609.9MMP9, MMP13
6p002459.8MMP9, MMP13, CRP
7ascorbic acid45 2410.8SERPINA1, PLOD2, MMP13, CRP
8fibrinogen459.7SERPINA1, MMP9, MMP13, CRP
9gi 254023x609.7MMP9, MMP13
10sb 20358045 6010.1CRP, MUC5AC, MMP13, MMP9
11paraffin458.9MUC5AC, MMP13, MMP9, SERPINA1

GO Terms for genes affiliated with Diverticulitis

Sources:
16Gene Ontology
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Biological processes related to Diverticulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lead ionGO:01028810.0SERPINA1, CRP
2response to hypoxiaGO:0016668.8SERPINA1, PLOD2, CRP, APOLD1

Products for genes affiliated with Diverticulitis

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  • Proteins
  • Lysates
  • Antibodies

Sources for Diverticulitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet