MCID: DVR002
MIFTS: 49

Diverticulitis malady

Gastrointestinal diseases category
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Summaries for Diverticulitis

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Wikipedia:65 Diverticulitis is a common digestive disease which involves the formation of pouches (diverticula)... more...

MalaCards based summary: Diverticulitis, also known as diverticulitis unspecified, is related to aneurysm and aortic aneurysm. An important gene associated with Diverticulitis is MMP13 (matrix metallopeptidase 13 (collagenase 3)), and among its related pathways are Selected targets of HNF1 and AGE/RAGE pathway. The drugs scopolamine and scopolamine hydrobromide and the compounds (4-aminophenyl)mercuric acetate and uk 383367 have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and heart.

Aliases & Classifications for Diverticulitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Diverticulitis, Aliases & Descriptions:

Name: Diverticulitis 8 10 44 62
Diverticulitis Unspecified 8
 
Diverticulitis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:7475
NCIt39 C26752
MeSH34 D004238

Related Diseases for Diverticulitis

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Diseases related to Diverticulitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm30.4SERPINA1, MMP9
2aortic aneurysm30.3CRP
3abdominal aortic aneurysm30.3MMP13, MMP9
4colorectal cancer30.1MMP13, SERPINA1, MUC5AC, MMP9
5lung cancer29.9MMP13, SERPINA1, MMP9, MUC5AC
6meningitis29.9MMP9, CRP
7ulcerative colitis29.9SERPINA1, CRP, MMP13
8inflammatory bowel disease29.8SERPINA1, MUC5AC, MMP13, CRP
9chronic obstructive pulmonary disease29.8MMP9, CRP, SERPINA1
10arthritis29.7MMP13, MMP9, CRP
11meckel's diverticulitis10.7
12peritonitis10.6
13appendicitis10.6
14wegener's granulomatosis10.5SERPINA1
15diverticulitis of colon10.4
16corneal ulcer10.4MUC5AC
17duodenitis10.3
18pulmonary emphysema10.3SERPINA1, MMP9
19obesity10.3
20colon cancer10.3
21thrombophlebitis10.3
22spiradenoma10.3MUC5AC, SERPINA1
23bone cancer10.2MMP9, MMP13
24periodontitis10.2MMP13, MMP9
25necrotizing fasciitis10.2
26fasciitis10.2
27synovitis10.2CRP, MMP13
28viral meningitis10.1SERPINA1, CRP
29irritable bowel syndrome10.1
30small intestine diverticulitis10.1
31colitis10.1
32williams syndrome10.1
33bronchitis10.1SERPINA1, CRP
34ankylosing spondylitis10.1SERPINA1, CRP
35respiratory failure10.1SERPINA1, CRP
36pancreatitis, chronic10.1SERPINA1, MUC5AC
37arthropathy10.1CRP, MMP13
38crohn's disease10.1
39hepatitis10.1
40morbid obesity10.1
41williams-beuren syndrome10.1
42polycystic kidney disease10.1
43endocarditis10.1
44kidney disease10.1
45schistosomiasis10.1
46ileus10.1
47blindness10.1
48epididymitis10.1
49carotid stenosis10.1MMP9, CRP
50cork-handlers' disease10.0MMP9, SERPINA1, MUC5AC

Graphical network of the top 20 diseases related to Diverticulitis:



Diseases related to diverticulitis

Symptoms for Diverticulitis

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Drugs & Therapeutics for Diverticulitis

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Drug clinical trials:

Search ClinicalTrials for Diverticulitis

Search NIH Clinical Center for Diverticulitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Diverticulitis

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Anatomical Context for Diverticulitis

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MalaCards organs/tissues related to Diverticulitis:

32
Colon, Small intestine, Heart, Kidney, Liver, Lung, Brain, Breast, Prostate, Testes, Appendix

Animal Models for Diverticulitis or affiliated genes

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Publications for Diverticulitis

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Articles related to Diverticulitis:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Incidence and predictive factors of irritable bowel syndrome after acute diverticulitis in Korea. (25255851)
2014
2
CT diagnosis of a post-embolization ischemic diverticulitis of Meckel. (25379178)
2014
3
Nonoperative management of acute complicated diverticulitis. (25360424)
2014
4
Rifaximin plus fibre versus fibre alone in preventing diverticulitis recurrence: a (problematic) trial to tackle an epidemiologically relevant problem. (23298762)
2013
5
The role of abdominal imaging in cases with a high probability of acute left-sided colonic diverticulitis based on a clinical scoring system. (23774316)
2013
6
Laparoscopic versus open Hartmann procedure for the emergency treatment of diverticulitis: a propensity-matched analysis. (23222283)
2013
7
Nonoperative management of complicated diverticulitis with extradigestive air. (23711261)
2013
8
Detection of endoscopic and histological inflammation after an attack of colonic diverticulitis is associated with higher diverticulitis recurrence. (23539385)
2013
9
Position paper: management of perforated sigmoid diverticulitis. (24369826)
2013
10
Re: Mandatory exploration is not necessary for patients with acute diverticulitis and free intraperitoneal air. (23609295)
2013
11
Acute sigmoid diverticulitis within an incarcerated inguinal hernia in an adult: a first report. (23574826)
2013
12
Perforated diverticulitis with fistula mimicking an inguinal hernia. (23336644)
2013
13
Suspected left sided diverticulitis. (23447355)
2013
14
Small bowel diverticulitis masquerading as Crohn's disease. (23815990)
2013
15
Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis-a prospective randomized study. (24343275)
2013
16
Colonoscopy after CT diagnosis of diverticulitis to exclude colon cancer: a systematic literature review. (22517956)
2012
17
Laparoscopic lavage for perforated diverticulitis: a population analysis. (22874599)
2012
18
Stercoral colonic diverticulum perforation with jejunal diverticulitis mimicking upper gastrointestinal perforation. (22490417)
2012
19
Colouterine fistula caused by diverticulitis of the sigmoid colon. (23346512)
2012
20
Routine colonoscopy following acute uncomplicated diverticulitis. (21713756)
2011
21
Correlation between complicated diverticulitis and visceral fat. (22022188)
2011
22
How complicated is complicated diverticulitis?--phlegmonous diverticulitis revisited. (21830036)
2011
23
Co-morbidity and postsurgical outcome in patients with perforated sigmoid diverticulitis. (20676663)
2011
24
Older patients with diverticulitis have low recurrence rates and rarely need surgery. (21801956)
2011
25
Long-term follow-up after an initial episode of diverticulitis: what are the predictors of recurrence? (21304297)
2011
26
Cyclical increase in diverticulitis during the summer months. (21422363)
2011
27
Therapy of solitary cecal diverticulitis in a young patient with laparoscopic right hemicolectomy. (21857454)
2011
28
A case of colitis cystica profunda in association with diverticulitis. (21212765)
2011
29
Perforated left-sided diverticulitis with faecal peritonitis: is the Hinchey classification the best guide for surgical decision making? (21271350)
2011
30
Spectrum of disease and outcome among patients with acute diverticulitis. (20571265)
2010
31
Prospective randomized trial comparing short-term antibiotic therapy versus standard therapy for acute uncomplicated sigmoid diverticulitis. (20140619)
2010
32
Colovesical, coloenteric, colocutaneous fistula, and hip septic arthritis secondary to sigmoid diverticulitis. (20012298)
2010
33
Treatment of right colonic diverticulitis: the role of nonoperative treatment. (21221240)
2010
34
Outpatient treatment of patients with uncomplicated acute diverticulitis. (19906059)
2010
35
Ventricular septal diverticule and ventricular septal defect after penetrating cardiac trauma. (19196578)
2009
36
Nonreversal of Hartmann's procedure for diverticulitis: derivation of a scoring system to predict nonreversal. (19617751)
2009
37
Small bowel diverticulitis as a cause of acute abdomen. (19011578)
2009
38
Prospective evaluation of the value of magnetic resonance imaging in suspected acute sigmoid diverticulitis. (19502884)
2009
39
Randomized controlled trial of oral vs intravenous therapy for the clinically diagnosed acute uncomplicated diverticulitis. (19016815)
2009
40
Colonic diverticulitis in adolescents: an index case and associated syndromes. (19711089)
2009
41
Diverticulosis and diverticulitis. (19186323)
2008
42
Acute ulcerative jejunal diverticulitis: case report of an uncommon entity. (18985822)
2008
43
Sigmoid diverticulitis in patients with Williams-Beuren syndrome: relatively high prevalence and high complication rate in young adults with the syndrome. (16007633)
2005
44
Abdominal computerized tomography in the diagnosis of Meckel's diverticulitis in the adult. (11794933)
2001
45
Perforation of acute calculous Meckel's diverticulitis: a rare cause of acute abdomen in elderly. (11143326)
2000
46
Soft-tissue images. Meckel's diverticulitis. (10372008)
1999
47
Intestinal perforation by saline total gut lavage in occult diverticulitis. (9826157)
1998
48
Septic thrombophlebitis of the inferior mesenteric vein associated with diverticulitis CT diagnosis. (8744820)
1996
49
Surgical management in complications of diverticulitis of colon. (13661559)
1959
50
Neurilemmoma of the sigmoid colon, associated with diverticulitis as a cause of obstruction. (14388189)
1955

Variations for Diverticulitis

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Expression for genes affiliated with Diverticulitis

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Expression patterns in normal tissues for genes affiliated with Diverticulitis

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Pathways for genes affiliated with Diverticulitis

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Pathways related to Diverticulitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CRP, SERPINA1
29.8MMP9, MMP13
3
Show member pathways
9.8MMP9, MMP13
49.8MMP9, MMP13

Compounds for genes affiliated with Diverticulitis

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Compounds related to Diverticulitis according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate4410.1MMP9, MMP13
2uk 3833676110.1MMP13, MMP9
3gi 254023x6110.1MMP13, MMP9
4gm 60016110.1MMP13, MMP9
5hydroxamate4410.1MMP9, MMP13
6fosinopril44 1111.1MMP9, CRP
7marimastat44 61 1112.1MMP9, MMP13
8gabexate mesilate4410.1CRP, MMP9
9batimastat44 61 1112.0MMP9, MMP13
108-isoprostane4410.0CRP, MMP9
11alpha lipoic acid449.9MMP9, SERPINA1
12hydroxyproline44 24 1111.9MMP9, MMP13
13fenofibrate44 50 1111.9MMP9, CRP
14ivig449.8CRP, MMP9
15p002449.8CRP, MMP9, MMP13
16ascorbic acid44 2410.8SERPINA1, MMP13, CRP
17doxycycline44 1110.8MMP9, MMP13
18vitamin a44 24 1111.7CRP, MMP9, SERPINA1
19pioglitazone28 44 50 1112.7CRP, MMP9
20fluvastatin44 50 28 1112.6CRP, MMP9
21fibrinogen449.5SERPINA1, MMP13, MMP9, CRP
22prostaglandin449.3MUC5AC, MMP13, MMP9
23ribonucleic acid449.3MUC5AC, MMP13, MMP9
24methotrexate50 44 1111.2MUC5AC, MMP9, CRP
25pd 98,059449.2MMP9, MMP13, MUC5AC
26n acetylcysteine449.2CRP, MMP9, MUC5AC
27paraffin449.0SERPINA1, MUC5AC, MMP13, MMP9
28pge2449.0MUC5AC, MMP13, MMP9
29sb 20358044 6110.0CRP, MMP9, MMP13, MUC5AC
30hematoxylin448.9MMP9, MUC5AC
31estrogen448.9SERPINA1, MUC5AC, MMP13, MMP9
32cysteine448.8SERPINA1, MUC5AC, MMP13, MMP9
33serine448.6SERPINA1, MUC5AC, MMP13, MMP9, ACADS

GO Terms for genes affiliated with Diverticulitis

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Cellular components related to Diverticulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.1SERPINA1, MMP13, MMP9
2extracellular spaceGO:0056159.1CRP, MMP9, MMP13, SERPINA1
3extracellular regionGO:0055767.9CRP, MMP9, MMP13, SERPINA1, APOLD1, TNFRSF18

Biological processes related to Diverticulitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lead ionGO:0102889.8CRP, SERPINA1
2collagen catabolic processGO:0305749.8MMP9, MMP13
3acute-phase responseGO:0069539.5CRP, SERPINA1
4response to hypoxiaGO:0016669.2CRP, SERPINA1, APOLD1

Products for genes affiliated with Diverticulitis

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Sources for Diverticulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet