MCID: DVR002
MIFTS: 41

Diverticulitis malady

Summaries for Diverticulitis

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Wikipedia:63 Diverticulitis is a common digestive disease which involves the formation of pouches (diverticula)... more...

MalaCards based summary: Diverticulitis, also known as diverticulitis unspecified, is related to aneurysm and aortic aneurysm. An important gene associated with Diverticulitis is MMP13 (matrix metallopeptidase 13 (collagenase 3)), and among its related pathways are Selected targets of HNF1 and AGE/RAGE pathway. The drugs scopolamine and scopolamine hydrobromide and the compounds (4-aminophenyl)mercuric acetate and uk 383367 have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and heart.

Aliases & Classifications for Diverticulitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Diverticulitis, Aliases & Descriptions:

Name: Diverticulitis 9 11 43 60
Diverticulitis Unspecified 9
 
Diverticulitis Nos 9


External Ids:

Disease Ontology9 DOID:7475
NCIt38 C26752
MeSH33 D004238

Related Diseases for Diverticulitis

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Diseases related to Diverticulitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1aneurysm30.4SERPINA1, MMP9
2aortic aneurysm30.3CRP
3abdominal aortic aneurysm30.2MMP9, MMP13
4colorectal cancer30.1SERPINA1, MUC5AC, MMP13, MMP9
5lung cancer29.9MUC5AC, MMP13, MMP9
6meningitis29.8MMP9, CRP
7ulcerative colitis29.8SERPINA1, MMP13, CRP
8inflammatory bowel disease29.8SERPINA1, MUC5AC, MMP13, CRP
9arthritis29.7CRP, MMP9, MMP13
10meckel's diverticulitis10.8
11appendicitis10.6
12peritonitis10.6
13diverticulitis of colon10.5
14wegener granulomatosis10.4SERPINA1
15corneal ulcer10.4MUC5AC
16duodenitis10.3
17pulmonary emphysema10.3MMP9, SERPINA1
18obesity10.3
19necrotizing fasciitis10.3
20fasciitis10.3
21thrombophlebitis10.3
22spiradenoma10.2SERPINA1, MUC5AC
23bone cancer10.2MMP13, MMP9
24small intestine diverticulitis10.2
25periodontitis10.2MMP9, MMP13
26synovitis10.2CRP, MMP13
27irritable bowel syndrome10.1
28colitis10.1
29viral meningitis10.1CRP, SERPINA1
30bronchitis10.1CRP, SERPINA1
31spondyloarthropathy 110.1SERPINA1, CRP
32respiratory failure10.1CRP, SERPINA1
33pancreatitis, hereditary10.1MUC5AC, SERPINA1
34williams-beuren syndrome10.1
35crohn's disease10.1
36morbid obesity10.1
37polycystic kidney disease10.1
38endocarditis10.1
39intestinal obstruction10.1
40kidney disease10.1
41schistosomiasis10.1
42ileus10.1
43blindness10.1
44epididymitis10.1
45arthropathy10.1CRP, MMP13
46carotid stenosis10.1CRP, MMP9
47cork-handlers' disease10.0SERPINA1, MUC5AC, MMP9
48kawasaki disease10.0CRP, MMP9
49lung cancer susceptibility 310.0SERPINA1, MUC5AC, MMP9
50acute pancreatitis10.0CRP, SERPINA1

Graphical network of the top 20 diseases related to Diverticulitis:



Diseases related to diverticulitis

Symptoms for Diverticulitis

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Drugs & Therapeutics for Diverticulitis

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Drug clinical trials:

Search ClinicalTrials for Diverticulitis

Search NIH Clinical Center for Diverticulitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Diverticulitis

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Anatomical Context for Diverticulitis

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MalaCards organs/tissues related to Diverticulitis:

31
Colon, Small intestine, Heart, Kidney, Liver, Lung, Brain, Breast, Prostate, Testes, Appendix

Animal Models for Diverticulitis or affiliated genes

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Publications for Diverticulitis

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Articles related to Diverticulitis:

(show top 50)    (show all 602)
idTitleAuthorsYear
1
Incidence and predictive factors of irritable bowel syndrome after acute diverticulitis in Korea. (25255851)
2014
2
CT diagnosis of a post-embolization ischemic diverticulitis of Meckel. (25379178)
2014
3
Nonoperative management of acute complicated diverticulitis. (25360424)
2014
4
Rifaximin plus fibre versus fibre alone in preventing diverticulitis recurrence: a (problematic) trial to tackle an epidemiologically relevant problem. (23298762)
2013
5
The role of abdominal imaging in cases with a high probability of acute left-sided colonic diverticulitis based on a clinical scoring system. (23774316)
2013
6
Laparoscopic versus open Hartmann procedure for the emergency treatment of diverticulitis: a propensity-matched analysis. (23222283)
2013
7
Nonoperative management of complicated diverticulitis with extradigestive air. (23711261)
2013
8
Detection of endoscopic and histological inflammation after an attack of colonic diverticulitis is associated with higher diverticulitis recurrence. (23539385)
2013
9
Position paper: management of perforated sigmoid diverticulitis. (24369826)
2013
10
Acute sigmoid diverticulitis within an incarcerated inguinal hernia in an adult: a first report. (23574826)
2013
11
Perforated diverticulitis with fistula mimicking an inguinal hernia. (23336644)
2013
12
Suspected left sided diverticulitis. (23447355)
2013
13
Small bowel diverticulitis masquerading as Crohn's disease. (23815990)
2013
14
Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis-a prospective randomized study. (24343275)
2013
15
Colonoscopy after CT diagnosis of diverticulitis to exclude colon cancer: a systematic literature review. (22517956)
2012
16
Laparoscopic lavage for perforated diverticulitis: a population analysis. (22874599)
2012
17
Stercoral colonic diverticulum perforation with jejunal diverticulitis mimicking upper gastrointestinal perforation. (22490417)
2012
18
Colouterine fistula caused by diverticulitis of the sigmoid colon. (23346512)
2012
19
Routine colonoscopy following acute uncomplicated diverticulitis. (21713756)
2011
20
Correlation between complicated diverticulitis and visceral fat. (22022188)
2011
21
How complicated is complicated diverticulitis?--phlegmonous diverticulitis revisited. (21830036)
2011
22
Co-morbidity and postsurgical outcome in patients with perforated sigmoid diverticulitis. (20676663)
2011
23
Older patients with diverticulitis have low recurrence rates and rarely need surgery. (21801956)
2011
24
Long-term follow-up after an initial episode of diverticulitis: what are the predictors of recurrence? (21304297)
2011
25
Cyclical increase in diverticulitis during the summer months. (21422363)
2011
26
Therapy of solitary cecal diverticulitis in a young patient with laparoscopic right hemicolectomy. (21857454)
2011
27
A case of colitis cystica profunda in association with diverticulitis. (21212765)
2011
28
Perforated left-sided diverticulitis with faecal peritonitis: is the Hinchey classification the best guide for surgical decision making? (21271350)
2011
29
Spectrum of disease and outcome among patients with acute diverticulitis. (20571265)
2010
30
Prospective randomized trial comparing short-term antibiotic therapy versus standard therapy for acute uncomplicated sigmoid diverticulitis. (20140619)
2010
31
Colovesical, coloenteric, colocutaneous fistula, and hip septic arthritis secondary to sigmoid diverticulitis. (20012298)
2010
32
Treatment of right colonic diverticulitis: the role of nonoperative treatment. (21221240)
2010
33
Outpatient treatment of patients with uncomplicated acute diverticulitis. (19906059)
2010
34
Colonic diverticulitis in the neck: a late complication of laryngopharyngectomy surgery. (20573308)
2010
35
Ventricular septal diverticule and ventricular septal defect after penetrating cardiac trauma. (19196578)
2009
36
Nonreversal of Hartmann's procedure for diverticulitis: derivation of a scoring system to predict nonreversal. (19617751)
2009
37
Small bowel diverticulitis as a cause of acute abdomen. (19011578)
2009
38
Prospective evaluation of the value of magnetic resonance imaging in suspected acute sigmoid diverticulitis. (19502884)
2009
39
Randomized controlled trial of oral vs intravenous therapy for the clinically diagnosed acute uncomplicated diverticulitis. (19016815)
2009
40
Colonic diverticulitis in adolescents: an index case and associated syndromes. (19711089)
2009
41
Diverticulosis and diverticulitis. (19186323)
2008
42
Acute ulcerative jejunal diverticulitis: case report of an uncommon entity. (18985822)
2008
43
Sigmoid diverticulitis in patients with Williams-Beuren syndrome: relatively high prevalence and high complication rate in young adults with the syndrome. (16007633)
2005
44
Abdominal computerized tomography in the diagnosis of Meckel's diverticulitis in the adult. (11794933)
2001
45
Perforation of acute calculous Meckel's diverticulitis: a rare cause of acute abdomen in elderly. (11143326)
2000
46
Soft-tissue images. Meckel's diverticulitis. (10372008)
1999
47
Intestinal perforation by saline total gut lavage in occult diverticulitis. (9826157)
1998
48
Septic thrombophlebitis of the inferior mesenteric vein associated with diverticulitis CT diagnosis. (8744820)
1996
49
Surgical management in complications of diverticulitis of colon. (13661559)
1959
50
Neurilemmoma of the sigmoid colon, associated with diverticulitis as a cause of obstruction. (14388189)
1955

Variations for Diverticulitis

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Expression for genes affiliated with Diverticulitis

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Search GEO for disease gene expression data for Diverticulitis.

Pathways for genes affiliated with Diverticulitis

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Pathways related to Diverticulitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MMP9, MMP13
2
Show member pathways
9.8MMP9, MMP13
39.8MMP9, MMP13

Compounds for genes affiliated with Diverticulitis

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Compounds related to Diverticulitis according to GeneCards Suite gene sharing:

(show all 33)
idCompoundScoreTop Affiliating Genes
1(4-aminophenyl)mercuric acetate4310.1MMP9, MMP13
2uk 3833675910.1MMP13, MMP9
3gi 254023x5910.1MMP13, MMP9
4gm 60015910.1MMP13, MMP9
5hydroxamate4310.1MMP9, MMP13
6fosinopril43 1211.1MMP9, CRP
7marimastat43 59 1212.1MMP9, MMP13
8gabexate mesilate4310.1CRP, MMP9
9batimastat43 59 1212.0MMP9, MMP13
108-isoprostane4310.0CRP, MMP9
11alpha lipoic acid439.9MMP9, SERPINA1
12hydroxyproline43 24 1211.9MMP9, MMP13
13fenofibrate43 49 1211.9MMP9, CRP
14ivig439.8CRP, MMP9
15p002439.8CRP, MMP9, MMP13
16ascorbic acid43 2410.8SERPINA1, MMP13, CRP
17doxycycline43 1210.8MMP9, MMP13
18vitamin a43 24 1211.7CRP, MMP9, SERPINA1
19pioglitazone28 43 49 1212.7CRP, MMP9
20fluvastatin43 49 28 1212.6CRP, MMP9
21fibrinogen439.5SERPINA1, MMP13, MMP9, CRP
22prostaglandin439.3MUC5AC, MMP13, MMP9
23ribonucleic acid439.3MUC5AC, MMP13, MMP9
24methotrexate49 43 1211.2MUC5AC, MMP9, CRP
25pd 98,059439.2MMP9, MMP13, MUC5AC
26n acetylcysteine439.2CRP, MMP9, MUC5AC
27paraffin439.0SERPINA1, MUC5AC, MMP13, MMP9
28pge2439.0MUC5AC, MMP13, MMP9
29sb 20358043 5910.0CRP, MMP9, MMP13, MUC5AC
30hematoxylin438.9MMP9, MUC5AC
31estrogen438.9SERPINA1, MUC5AC, MMP13, MMP9
32cysteine438.8SERPINA1, MUC5AC, MMP13, MMP9
33serine438.6SERPINA1, MUC5AC, MMP13, MMP9, ACADS

GO Terms for genes affiliated with Diverticulitis

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Cellular components related to Diverticulitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.1SERPINA1, MMP13, MMP9
2extracellular spaceGO:00056159.1CRP, MMP9, MMP13, SERPINA1
3extracellular regionGO:00055767.9CRP, MMP9, MMP13, SERPINA1, APOLD1, TNFRSF18

Biological processes related to Diverticulitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to lead ionGO:00102889.8CRP, SERPINA1
2collagen catabolic processGO:00305749.8MMP9, MMP13
3acute-phase responseGO:00069539.5CRP, SERPINA1
4response to hypoxiaGO:00016669.2CRP, SERPINA1, APOLD1

Products for genes affiliated with Diverticulitis

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  • Antibodies
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Sources for Diverticulitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet