MCID: DVR001
MIFTS: 34

Diverticulitis of Colon

Categories: Gastrointestinal diseases

Aliases & Classifications for Diverticulitis of Colon

MalaCards integrated aliases for Diverticulitis of Colon:

Name: Diverticulitis of Colon 12 14
Diverticular Disease of Colon 69
Colonic Diverticular Disease 12
Diverticulitis, Colonic 41

Classifications:



External Ids:

Disease Ontology 12 DOID:13254
ICD9CM 34 562.12
MeSH 41 D004239

Summaries for Diverticulitis of Colon

Disease Ontology : 12 A colonic disease characterized by the formation and inflammation of diverticula within the colon wall.

MalaCards based summary : Diverticulitis of Colon, also known as diverticular disease of colon, is related to autoimmune encephalitis and pain agnosia. An important gene associated with Diverticulitis of Colon is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Acetaminophen and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are behavior/neurological and integument

Related Diseases for Diverticulitis of Colon

Diseases related to Diverticulitis of Colon via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 autoimmune encephalitis 10.3 CNR1 TRPV1
2 pain agnosia 10.2 CNR1 TRPV1
3 diverticulitis 10.2
4 dental pulp disease 10.2 NPS TRPV1
5 agnosia 10.2 CNR1 TRPV1
6 indeterminate leprosy 10.1 NPS UCHL1
7 nasal cavity disease 10.1 NPS TRPV1
8 spinocerebellar ataxia 23 10.1 NPS TACR1
9 retinitis pigmentosa 68 10.1 NPS TACR1
10 testicular infarct 10.0 KIT UCHL1
11 malignant mesenchymoma 10.0 KIT UCHL1
12 perry syndrome 10.0 NPS TACR1
13 disease of mental health 9.9 CNR1 NPS TRPV1
14 connective tissue cancer 9.9 KIT TRPV1
15 cystitis 9.7 TACR1 TRPV1
16 peritonitis 9.7
17 constipation 9.7 KIT TACR1
18 parkinson disease, late-onset 9.7 CNR1 TRPV1 UCHL1
19 migraine with or without aura 1 9.6 CNR1 NPS TACR1 TRPV1

Graphical network of the top 20 diseases related to Diverticulitis of Colon:



Diseases related to Diverticulitis of Colon

Symptoms & Phenotypes for Diverticulitis of Colon

MGI Mouse Phenotypes related to Diverticulitis of Colon:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 ACADS BRD2 CNR1 KIT TACR1 TRPV1
2 integument MP:0010771 9.43 ACADS CNR1 KIT TACR1 TRPV1 UCHL1
3 liver/biliary system MP:0005370 9.02 ACADS BRD2 KIT TRPV1 UCHL1

Drugs & Therapeutics for Diverticulitis of Colon

Drugs for Diverticulitis of Colon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
5
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
6
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
7
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
8
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
9
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
10
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
11
Methadone Approved Phase 4 76-99-3 4095
12
Morphine Approved, Investigational Phase 4 57-27-2 5288826
13
Orphenadrine Approved Phase 4 83-98-7 4601
14
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
15
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
16 Liver Extracts Phase 4
17 Acetaminophen, hydrocodone drug combination Phase 4
18 Adjuvants, Anesthesia Phase 4
19 Analgesics Phase 4
20 Analgesics, Non-Narcotic Phase 4
21 Analgesics, Opioid Phase 4
22 Anesthetics Phase 4
23 Anesthetics, Dissociative Phase 4
24 Anesthetics, General Phase 4
25 Anesthetics, Intravenous Phase 4
26 Anesthetics, Local Phase 4
27 Anti-Anxiety Agents Phase 4
28 Anti-Arrhythmia Agents Phase 4
29 Anticonvulsants Phase 4
30 Anti-Inflammatory Agents Phase 4
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4
32 Antimanic Agents Phase 4
33 Antiparkinson Agents Phase 4
34 Antipyretics Phase 4
35 Antirheumatic Agents Phase 4
36 Antitussive Agents Phase 4
37 Autonomic Agents Phase 4
38 calcium channel blockers Phase 4
39 Calcium, Dietary Phase 4
40 Central Nervous System Depressants Phase 4
41 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
42 Cholinergic Agents Phase 4
43 Cholinergic Antagonists Phase 4
44 Cyclooxygenase Inhibitors Phase 4
45 Cytochrome P-450 Enzyme Inhibitors Phase 4
46 Diuretics, Potassium Sparing Phase 4
47 Excitatory Amino Acid Antagonists Phase 4
48 Excitatory Amino Acids Phase 4
49 Ketorolac Tromethamine Phase 4
50 Muscarinic Antagonists Phase 4

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Prevalence of Colon Cancer in Pyogenic Liver Abscess Completed NCT02032914 Phase 4
2 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
3 Hartmann vs R/A in Peritonitis by Perforated Diverticulitis Completed NCT01239927 Phase 2, Phase 3
4 Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis Completed NCT01008488 Antibiotic
5 The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis Completed NCT01515150
6 Primary vs. Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis a Prospective Randomized Trial Completed NCT00692393
7 Colonic Resections in Patients With Suspected Appendicitis Completed NCT00888888
8 Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis Recruiting NCT03279588
9 Laparoscopic-lavage Observational Study Recruiting NCT02662088
10 Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study) Recruiting NCT03008707
11 Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study] Not yet recruiting NCT03448874
12 Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)? Not yet recruiting NCT03316677

Search NIH Clinical Center for Diverticulitis of Colon

Cochrane evidence based reviews: diverticulitis, colonic

Genetic Tests for Diverticulitis of Colon

Anatomical Context for Diverticulitis of Colon

MalaCards organs/tissues related to Diverticulitis of Colon:

38
Colon, Liver, Testes

Publications for Diverticulitis of Colon

Articles related to Diverticulitis of Colon:

# Title Authors Year
1
Experience of managing complicated diverticulitis of colon: a retrospective case series from South Asian country. ( 24864634 )
2014
2
Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. ( 12236485 )
2002
3
Unusual cases of perforated diverticulitis of colon. ( 2230705 )
1990
4
Case profile: unique uroradiographic manifestation of diverticulitis of colon. ( 7112836 )
1982
5
GENERALIZED PERITONITIS COMPLICATING ACUTE DIVERTICULITIS OF COLON. ( 14236316 )
1965
6
Surgical management in complications of diverticulitis of colon. ( 13661559 )
1959
7
Diverticulitis of colon and new aspects of its treatment with report of five cases. ( 14393950 )
1955
8
Surgical treatment of diverticulitis of colon. ( 13227745 )
1955
9
Intestinovesical fistula Report of three cases resulting from diverticulitis of colon. ( 14817551 )
1951

Variations for Diverticulitis of Colon

Expression for Diverticulitis of Colon

Search GEO for disease gene expression data for Diverticulitis of Colon.

Pathways for Diverticulitis of Colon

GO Terms for Diverticulitis of Colon

Biological processes related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 learning or memory GO:0007611 9.52 CNR1 TACR1
2 visual learning GO:0008542 9.51 KIT NPS
3 response to heat GO:0009408 9.49 TACR1 TRPV1
4 response to nicotine GO:0035094 9.48 CNR1 TACR1
5 response to morphine GO:0043278 9.46 CNR1 TACR1
6 eating behavior GO:0042755 9.43 TACR1 UCHL1
7 positive regulation of blood pressure GO:0045777 9.4 CNR1 TACR1
8 response to pain GO:0048265 9.37 TACR1 TRPV1
9 positive regulation of synaptic transmission, GABAergic GO:0032230 9.32 NPS TACR1
10 behavioral response to pain GO:0048266 9.26 TACR1 TRPV1
11 positive regulation of action potential GO:0045760 9.16 NPS TACR1
12 smooth muscle contraction involved in micturition GO:0060083 8.96 TACR1 TRPV1
13 sensory perception of pain GO:0019233 8.92 CNR1 TACR1 TRPV1 UCHL1

Sources for Diverticulitis of Colon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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