MCID: DVR001
MIFTS: 31

Diverticulitis of Colon

Categories: Gastrointestinal diseases

Aliases & Classifications for Diverticulitis of Colon

MalaCards integrated aliases for Diverticulitis of Colon:

Name: Diverticulitis of Colon 12 14
Diverticular Disease of Colon 69
Colonic Diverticular Disease 12
Diverticulitis, Colonic 42

Classifications:



External Ids:

Disease Ontology 12 DOID:13254
ICD9CM 35 562.12
MeSH 42 D004239
UMLS 69 C0156168

Summaries for Diverticulitis of Colon

Disease Ontology : 12 A colonic disease characterized by the formation and inflammation of diverticula within the colon wall.

MalaCards based summary : Diverticulitis of Colon, also known as diverticular disease of colon, is related to autoimmune inner ear disease and epulis. An important gene associated with Diverticulitis of Colon is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Ertapenem and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include colon and liver, and related phenotypes are behavior/neurological and integument

Related Diseases for Diverticulitis of Colon

Graphical network of the top 20 diseases related to Diverticulitis of Colon:



Diseases related to Diverticulitis of Colon

Symptoms & Phenotypes for Diverticulitis of Colon

MGI Mouse Phenotypes related to Diverticulitis of Colon:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 KIT TACR1 TRPV1 UCHL1 ACADS BRD2
2 integument MP:0010771 9.43 ACADS CNR1 KIT TACR1 TRPV1 UCHL1
3 liver/biliary system MP:0005370 9.02 ACADS BRD2 KIT TRPV1 UCHL1

Drugs & Therapeutics for Diverticulitis of Colon

Drugs for Diverticulitis of Colon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Metronidazole Approved Phase 4 443-48-1 4173
5
Bupivacaine Approved, Investigational Phase 4,Phase 1,Phase 2 2180-92-9, 38396-39-3 2474
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7 Racepinephrine Approved Phase 4
8
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
9
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
10
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
13
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
14
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
15
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
16
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
17
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
18
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
19
Methadone Approved Phase 4 76-99-3 4095
20
Orphenadrine Approved Phase 4 83-98-7 4601
21
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
22
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
23 Anti-Bacterial Agents Phase 4
24 Anti-Infective Agents Phase 4
25 Amoxicillin-Potassium Clavulanate Combination Phase 4
26 Antibiotics, Antitubercular Phase 4
27 Antitubercular Agents Phase 4
28 beta-Lactamase Inhibitors Phase 4
29 Clavulanic Acid Phase 4
30 Liver Extracts Phase 4
31 Analgesics Phase 4,Phase 1,Phase 2
32 Anesthetics Phase 4,Phase 2
33 Anesthetics, Local Phase 4,Phase 2
34 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
35 Epinephryl borate Phase 4
36 Narcotics Phase 4,Phase 1,Phase 2
37 Peripheral Nervous System Agents Phase 4,Phase 1,Phase 2
38 Gastrointestinal Agents Phase 4
39 Nucleic Acid Synthesis Inhibitors Phase 4
40 Analgesics, Opioid Phase 4,Phase 1,Phase 2
41 Anti-Arrhythmia Agents Phase 4,Phase 2
42 Diuretics, Potassium Sparing Phase 4,Phase 2
43 Sodium Channel Blockers Phase 4,Phase 2
44 Acetaminophen, hydrocodone drug combination Phase 4
45 Adjuvants, Anesthesia Phase 4
46 Analgesics, Non-Narcotic Phase 4
47 Anesthetics, Dissociative Phase 4
48 Anesthetics, General Phase 4
49 Anesthetics, Intravenous Phase 4
50 Anti-Anxiety Agents Phase 4

Interventional clinical trials:

(show all 44)

id Name Status NCT ID Phase Drugs
1 Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4 ertapenem
2 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
3 Diverticulitis: Antibiotics or Close Observation? Unknown status NCT01111253 Phase 4 Amoxicillin-clavulanate
4 Prevalence of Colon Cancer in Pyogenic Liver Abscess Completed NCT02032914 Phase 4
5 The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery Completed NCT02052557 Phase 4 Bupivacaine;Bupivacaine liposome suspension
6 Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease Completed NCT00453830 Phase 4
7 Immunohistology in USDD and Correlation Between Bacterial Flora and Phlogosis Completed NCT02068482 Phase 4 Rifaximin
8 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
9 Laparoscopic Peritoneal Lavage or Resection for Generalised Peritonitis for Perforated Diverticulitis Unknown status NCT01317485 Phase 3
10 Hartmann vs R/A in Peritonitis by Perforated Diverticulitis Completed NCT01239927 Phase 2, Phase 3
11 Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation Completed NCT01233713 Phase 2, Phase 3
12 Effect of a Probiotic on Diverticular Symptoms Completed NCT02115867 Phase 3
13 Single Port Colic Laparoscopic Surgery Recruiting NCT01959087 Phase 3
14 Spinal Analgesia for Colonic Resection Using an Enhanced Recovery After Surgery (ERAS) Program Completed NCT01477190 Phase 1, Phase 2 Spinal analgesia;Patient Control Analgesia (PCA) Morphine
15 Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine Completed NCT01155440 Phase 2 Lidocaine
16 Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells in Inflammatory Bowel Disease Recruiting NCT02952131 Phase 1, Phase 2
17 Asimadoline for the Treatment of Post-Operative Ileus Terminated NCT00443040 Phase 2 Asimadoline;Placebo
18 Perfusion Assessment in Laparoscopic Left Anterior Resection Completed NCT01560377 Phase 1
19 Pathophysiology of Diverticular Disease Unknown status NCT01493349
20 Natural History of Sigmoid Diverticulitis: The Geneva Cohort Study Unknown status NCT01015378
21 The Gut Microbiome in Diverticulitis and Diverticulosis Unknown status NCT02221713
22 Fluorescent Evaluation of Colorectal Anastamoses Unknown status NCT01424293
23 Recurrence Following CT-guided Drainage of 1st Episode Hinchey II Diverticulitis Unknown status NCT01986686
24 Feasibility, Safety and Outcome of Transrectal Hybrid-NOTES Anterior Resection Unknown status NCT01992406
25 Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis Completed NCT01008488 Antibiotic
26 The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis Completed NCT01515150
27 Primary vs. Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis a Prospective Randomized Trial Completed NCT00692393
28 Colonic Resections in Patients With Suspected Appendicitis Completed NCT00888888
29 Italian Study Group on Complicated Diverticulosis Completed NCT01276886 antibiotic
30 Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine Completed NCT00982618 Lidocaine;PCA Morphine
31 Laparoscopic Transvaginal Hybrid Anterior Resection: a Prospective Data Collection Completed NCT01043731
32 Early Post-Op Recovery After Partial Large Bowel Resection Completed NCT00492193
33 Prevention of Diverticulitis by Taking a Daily Probiotic Completed NCT01609751
34 Follow-Up Phone Calls After Colorectal Surgery Completed NCT00474097
35 Post-Op Quality of Life After Colorectal Surgery Completed NCT00468455
36 Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis Recruiting NCT03279588
37 Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis : a Multicenter Prospective Observational Study (STELLA Study) Recruiting NCT03008707
38 Predictive Value of DICA in the Diverticular Disease of the Colon Recruiting NCT02758860
39 DEBUT: Diverticulitis Evaluation of Patient Burden, Utilization, and Trajectory Recruiting NCT02776787
40 LASER Trial. LAparoscopic Elective Sigmoid Resection Following divERticulitis - a Multicenter, Prospective, Randomized Clinical Trial Recruiting NCT02174926
41 Perfusion Evaluation by Real-time Fluorescence-based Enhanced Reality of Anastomosis Recruiting NCT02626091
42 Randomized Clinical Trial for the Uncomplicated Diverticulitis in Right Colon Active, not recruiting NCT02314013 Cephalosporin + Metronidazole
43 Laparoscopic-lavage Observational Study Not yet recruiting NCT02662088
44 Local Anesthetic Wound Infusion and Functional Recovery After Colon Surgery Terminated NCT01062919

Search NIH Clinical Center for Diverticulitis of Colon

Cochrane evidence based reviews: diverticulitis, colonic

Genetic Tests for Diverticulitis of Colon

Anatomical Context for Diverticulitis of Colon

MalaCards organs/tissues related to Diverticulitis of Colon:

39
Colon, Liver

Publications for Diverticulitis of Colon

Articles related to Diverticulitis of Colon:

id Title Authors Year
1
Experience of managing complicated diverticulitis of colon: a retrospective case series from South Asian country. ( 24864634 )
2014
2
Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. ( 12236485 )
2002
3
Unusual cases of perforated diverticulitis of colon. ( 2230705 )
1990
4
Case profile: unique uroradiographic manifestation of diverticulitis of colon. ( 7112836 )
1982
5
GENERALIZED PERITONITIS COMPLICATING ACUTE DIVERTICULITIS OF COLON. ( 14236316 )
1965
6
Surgical management in complications of diverticulitis of colon. ( 13661559 )
1959
7
Surgical treatment of diverticulitis of colon. ( 13227745 )
1955
8
Diverticulitis of colon and new aspects of its treatment with report of five cases. ( 14393950 )
1955
9
Intestinovesical fistula Report of three cases resulting from diverticulitis of colon. ( 14817551 )
1951

Variations for Diverticulitis of Colon

Expression for Diverticulitis of Colon

Search GEO for disease gene expression data for Diverticulitis of Colon.

Pathways for Diverticulitis of Colon

GO Terms for Diverticulitis of Colon

Biological processes related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 learning or memory GO:0007611 9.52 CNR1 TACR1
2 response to heat GO:0009408 9.51 TACR1 TRPV1
3 visual learning GO:0008542 9.49 KIT NPS
4 response to nicotine GO:0035094 9.48 CNR1 TACR1
5 response to morphine GO:0043278 9.46 CNR1 TACR1
6 eating behavior GO:0042755 9.43 TACR1 UCHL1
7 positive regulation of blood pressure GO:0045777 9.4 CNR1 TACR1
8 response to pain GO:0048265 9.37 TACR1 TRPV1
9 positive regulation of synaptic transmission, GABAergic GO:0032230 9.32 NPS TACR1
10 behavioral response to pain GO:0048266 9.26 TACR1 TRPV1
11 positive regulation of action potential GO:0045760 9.16 NPS TACR1
12 smooth muscle contraction involved in micturition GO:0060083 8.96 TACR1 TRPV1
13 sensory perception of pain GO:0019233 8.92 CNR1 TACR1 TRPV1 UCHL1

Sources for Diverticulitis of Colon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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