XLCM
MCID: DMD003
MIFTS: 21

Dmd-Associated Dilated Cardiomyopathy (XLCM) malady

Cardiovascular diseases, Muscle diseases categories

Summaries for Dmd-Associated Dilated Cardiomyopathy

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21Genetics Home Reference, 46OMIM, 32MalaCards
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Genetics Home Reference:21 DMD-associated dilated cardiomyopathy is a form of heart disease that is caused by mutations in the DMD gene. Dilated cardiomyopathy enlarges and weakens the heart (cardiac) muscle, preventing the heart from pumping blood efficiently. Signs and symptoms of this condition can include an irregular heartbeat (arrhythmia), shortness of breath, extreme tiredness (fatigue), and swelling of the legs and feet. In males with DMD-associated dilated cardiomyopathy, heart problems usually develop early in life and worsen quickly, leading to heart failure in adolescence or early adulthood. In affected females, the condition appears later in life and worsens more slowly.

MalaCards: Dmd-Associated Dilated Cardiomyopathy, also known as dmd-related dilated cardiomyopathy, is related to duchenne muscular dystrophy and muscular dystrophy. An important gene associated with Dmd-Associated Dilated Cardiomyopathy is DMD (dystrophin). Affiliated tissues include heart.

Description from OMIM:46 302045

Aliases & Classifications for Dmd-Associated Dilated Cardiomyopathy

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Sources:
20GeneTests, 21Genetics Home Reference, 46OMIM, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Muscle diseases


Aliases & Descriptions:

dmd-associated dilated cardiomyopathy 20 21
dmd-related dilated cardiomyopathy 21
cardiomyopathy, dilated, x-linked 44
x-linked dilated cardiomyopathy 21
muscular dystrophy, duchenne 60
cardiomyopathy, dilated, 3b 46
dilated cardiomyopathy 3b 21
cmd3b 21
xldc 21
xlcm 21


Related Diseases for Dmd-Associated Dilated Cardiomyopathy

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17GeneCards, 18GeneDecks
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Diseases related to Dmd-Associated Dilated Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1duchenne muscular dystrophy11.0
2muscular dystrophy10.9
3dilated cardiomyopathy10.8
4muscular dystrophy, duchenne and becker types10.7
5becker muscular dystrophy10.6
6dmd-related dilated cardiomyopathy10.4
7neutropenia10.2
8dystrophinopathies10.2
9congenital muscular dystrophy10.2

Graphical network of diseases related to Dmd-Associated Dilated Cardiomyopathy:



Diseases related to dmd-associated dilated cardiomyopathy

Clinical Features for Dmd-Associated Dilated Cardiomyopathy

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46OMIM
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Clinical features from OMIM:

302045

Clinical synopsis from OMIM:

302045

Drugs & Therapeutics for Dmd-Associated Dilated Cardiomyopathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dmd-Associated Dilated Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Dmd-Associated Dilated Cardiomyopathy

Search NIH Clinical Center for Dmd-Associated Dilated Cardiomyopathy

Search CenterWatch for Dmd-Associated Dilated Cardiomyopathy

Genetic Tests for Dmd-Associated Dilated Cardiomyopathy

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20GeneTests
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Genetic tests related to Dmd-Associated Dilated Cardiomyopathy:

id Genetic test Affiliating Genes
1 Dmd-Associated Dilated Cardiomyopathy20 DMD

Anatomical Context for Dmd-Associated Dilated Cardiomyopathy

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32MalaCards
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MalaCards organs/tissues related to Dmd-Associated Dilated Cardiomyopathy:

32
Heart

Animal Models for Dmd-Associated Dilated Cardiomyopathy or affiliated genes

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Publications for Dmd-Associated Dilated Cardiomyopathy

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Genetic Variations for Dmd-Associated Dilated Cardiomyopathy

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Dmd-Associated Dilated Cardiomyopathy:

62
id Symbol AA change Variation ID SNP ID
1DMDp.Lys18AsnVAR_023537
2DMDp.Thr279AlaVAR_023540
3DMDp.Asn1672LysVAR_023542rs16990264
4DMDp.Phe3228LeuVAR_023544

Expression for genes affiliated with Dmd-Associated Dilated Cardiomyopathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dmd-Associated Dilated Cardiomyopathy

Search GEO for disease gene expression data for Dmd-Associated Dilated Cardiomyopathy.

Pathways for genes affiliated with Dmd-Associated Dilated Cardiomyopathy

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Compounds for genes affiliated with Dmd-Associated Dilated Cardiomyopathy

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GO Terms for genes affiliated with Dmd-Associated Dilated Cardiomyopathy

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Products for genes affiliated with Dmd-Associated Dilated Cardiomyopathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dmd-Associated Dilated Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet