MCID: DXR001
MIFTS: 38

Doxorubicin Induced Cardiomyopathy malady

Cardiovascular category

Summaries for Doxorubicin Induced Cardiomyopathy

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33MalaCards
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MalaCards: Doxorubicin Induced Cardiomyopathy is related to mitochondrial cardiomyopathy and stress cardiomyopathy. An important gene associated with Doxorubicin Induced Cardiomyopathy is GATA4 (GATA binding protein 4), and among its related pathways are CREB Pathway and Syndecan-1-mediated signaling events. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and myeloid, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Doxorubicin Induced Cardiomyopathy

Sources:
43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

doxorubicin induced cardiomyopathy 43


Related Diseases for Doxorubicin Induced Cardiomyopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Doxorubicin Induced Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1mitochondrial cardiomyopathy10.4
2stress cardiomyopathy10.3
3hypertrophic cardiomyopathy10.2
4soft tissue sarcoma10.2
5wilms tumor10.0DES
6endometriosis10.0HGF
7hepatitis10.0HGF
8primary hyperoxaluria10.0EPOR
9fibrosarcoma10.0DES
10polycythemia10.0EPOR
11hemangioblastoma10.0EPOR
12gastrointestinal stromal tumor10.0DES
13amyotrophic lateral sclerosis10.0CNR1
14chordoma10.0DES
15glomerulonephritis10.0EPOR
16leiomyoma10.0DES
17polycythemia vera10.0EPOR
18teratoma10.0GATA4
19bladder carcinoma10.0BAX
20neurofibroma10.0MET
21alexander disease10.0DES
22multiple myeloma10.0CSF3
23leiomyosarcoma10.0DES
24liposarcoma10.0DES
25medulloblastoma10.0HGF, DES
26thyroid cancer10.0MET, EPOR
27esophageal cancer10.0EGFR
28rhabdomyosarcoma10.0MET, DES
29sarcoma10.0DES, MET
30schizophrenia10.0CNR1
31hepatopulmonary syndrome10.0EDN1
32acute myocardial infarction10.0EDN1
33chondrosarcoma10.0MET, DES
34laryngeal carcinoma10.0EGFR
35meconium aspiration syndrome10.0EDN1
36salivary gland cancer10.0MET, HGF
37acute leukemia10.0EPOR, CSF3
38rheumatoid arthritis10.0MAPK14
39arthritis10.0MAPK14
40arteriosclerosis obliterans10.0HGF
41pulmonary fibrosis10.0EDN1, HGF
42hypertension10.0EDN1, ECE1
43myelodysplastic syndromes10.0CSF3, EPOR
44hepatitis c10.0MAPK14
45psoriasis10.0MAPK14
46skin cancer10.0MAPK14
47coronary heart disease10.0EDN1
48malignant mesothelioma10.0HGF, DES, MET
49myeloid leukemia10.0BAX, CSF3
50hepatoblastoma10.0EPOR, MET, HGF

Graphical network of the top 20 diseases related to Doxorubicin Induced Cardiomyopathy:



Diseases related to doxorubicin induced cardiomyopathy

Clinical Features for Doxorubicin Induced Cardiomyopathy

Drugs & Therapeutics for Doxorubicin Induced Cardiomyopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Doxorubicin Induced Cardiomyopathy

Drug clinical trials:

Search ClinicalTrials for Doxorubicin Induced Cardiomyopathy

Search NIH Clinical Center for Doxorubicin Induced Cardiomyopathy

Search CenterWatch for Doxorubicin Induced Cardiomyopathy

Genetic Tests for Doxorubicin Induced Cardiomyopathy

Anatomical Context for Doxorubicin Induced Cardiomyopathy

Sources:
33MalaCards
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MalaCards organs/tissues related to Doxorubicin Induced Cardiomyopathy:

33
Bone marrow, Heart, Myeloid, T cells, Pituitary

Animal Models for Doxorubicin Induced Cardiomyopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Doxorubicin Induced Cardiomyopathy:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.3ECE1
2MP:00053679.5EGFR, EDN1
3MP:00053809.4EPOR, ECE1, EDN1, GATA4
4MP:00053909.4GATA4, BAX, ECE1, CNR1
5MP:00053769.1GATA4, DES, MAPK14, CNR1
6MP:00036318.9GATA4, EDN1, BAX, ECE1, CNR1
7MP:00053798.9GATA4, BAX, MAPK14, ECE1
8MP:00053698.6GATA4, MET, BAX, MAPK14, ECE1
9MP:00030128.4HGF, GATA4, MET, EGFR, CNR1, EPOR
10MP:00053898.1GATA4, EGFR, BAX, CNR1, EPHB2
11MP:00053828.1EDN1, MET, EGFR, ECE1, EPHB2
12MP:00053708.0HGF, GATA4, MET, EGFR, MAPK14, EPOR
13MP:00053817.9GATA4, EDN1, MET, EGFR, ECE1, CNR1
14MP:00053887.7GATA4, MET, EGFR, BAX, MAPK14, EPOR
15MP:00028737.5GATA4, EDN1, MET, EGFR, MAPK14, ECE1
16MP:00053977.1HGF, CSF3, GATA4, EGFR, BAX, MAPK14
17MP:00053877.1MET, EGFR, BAX, MAPK14, ECE1, EPOR
18MP:00053857.0HGF, GATA4, EDN1, MET, EGFR, DES
19MP:00053786.9HGF, GATA4, MET, EGFR, BAX, MAPK14
20MP:00053846.9HGF, GATA4, MET, EGFR, BAX, MAPK14
21MP:00107685.8EPOR, HGF, GATA4, EDN1, MET, EGFR

Publications for Doxorubicin Induced Cardiomyopathy

Sources:
51PubMed
See all sources

Articles related to Doxorubicin Induced Cardiomyopathy:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats. (24228260)
2013
2
Doxorubicin induced dilated cardiomyopathy in a rabbit model: an update. (22902286)
2013
3
Increased beta2-adrenoceptors in doxorubicin-induced cardiomyopathy in rat. (23741376)
2013
4
Macrophage migration inhibitory factor deficiency augments doxorubicin-induced cardiomyopathy. (24334905)
2013
5
Embryonic stem cells improve cardiac function in Doxorubicin-induced cardiomyopathy mediated through multiple mechanisms. (22449713)
2012
6
Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. (22465037)
2012
7
Discordant impairment of multidirectional myocardial deformation in rats with Doxorubicin induced cardiomyopathy. (22486544)
2012
8
Fosinopril attenuates the doxorubicin-induced cardiomyopathy by restoring the function of sarcoplasmic reticulum. (22729889)
2012
9
Heat shock protein 25-enriched plasma transfusion preconditions the heart against doxorubicin-induced dilated cardiomyopathy in mice. (22438470)
2012
10
Potential biomarkers in mouse myocardium of doxorubicin-induced cardiomyopathy: a metabonomic method and its application. (22110719)
2011
11
Thrombopoietin protects against doxorubicin-induced cardiomyopathy, improves cardiac function, and reversely alters specific signalling networks. (21330293)
2011
12
Dietary nitrate supplementation protects against Doxorubicin-induced cardiomyopathy by improving mitochondrial function. (21596234)
2011
13
Bovine model of doxorubicin-induced cardiomyopathy. (21253525)
2011
14
Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy. (21624372)
2011
15
Diclofenac sodium, a nonselective nonsteroidal anti-inflammatory drug aggravates doxorubicin-induced cardiomyopathy in rats. (19920767)
2010
16
CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. (19942623)
2010
17
Evaluation of the topoisomerase II-inactive bisdioxopiperazine ICRF-161 as a protectant against doxorubicin-induced cardiomyopathy. (19010377)
2009
18
Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 receptor. (18627295)
2008
19
Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats. (18806609)
2008
20
Myocardial strain analysis in a doxorubicin-induced cardiomyopathy model. (17935862)
2008
21
Usefulness of cardiac resynchronization therapy in the management of Doxorubicin-induced cardiomyopathy. (18435975)
2008
22
Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy. (17334414)
2007
23
Preventive cardioprotection of erythropoietin against doxorubicin-induced cardiomyopathy. (17924179)
2007
24
Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. (17329180)
2007
25
Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy. (16449733)
2006
26
Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathy. (16731534)
2006
27
Plasma concentrations of NT-pro-BNP and cardiac troponin-I in relation to doxorubicin-induced cardiomyopathy and cardiac function in childhood malignancy. (16127512)
2005
28
Anti-oxidants and apoptosis: attenuation of doxorubicin induced cardiomyopathy by carvedilol. (15380672)
2004
29
Bone marrow mononuclear cell transplantation had beneficial effects on doxorubicin-induced cardiomyopathy. (15063403)
2004
30
Concurrent therapies that protect against doxorubicin-induced cardiomyopathy. (15515283)
2004
31
Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy. (12498738)
2002
32
Doxorubicin-induced cardiomyopathy during pregnancy: three case reports of anesthetic management for cesarean and vaginal delivery in two kyphoscoliotic patients. (12151947)
2002
33
Dietary fish oil does not prevent doxorubicin-induced cardiomyopathy in rats. (11907617)
2002
34
Evaluation of cardiac adrenergic neuronal damage in rats with doxorubicin-induced cardiomyopathy using iodine-131 MIBG autoradiography and PGP 9.5 immunohistochemistry. (10901455)
2000
35
Doxorubicin-induced cardiomyopathy. (10049085)
1999
36
Doxorubicin-induced cardiomyopathy. (10049087)
1999
37
Doxorubicin-induced cardiomyopathy. (10049086)
1999
38
Doxorubicin-induced cardiomyopathy. (10049088)
1999
39
The role of iron in doxorubicin-induced cardiomyopathy. (9768818)
1998
40
Contractile failure in chronic doxorubicin-induced cardiomyopathy. (9344758)
1997
41
Review of tests for monitoring doxorubicin-induced cardiomyopathy. (8960141)
1996
42
Doxorubicin-induced cardiomyopathy. (7946145)
1994
43
Etiology of sarcoplasmic reticulum calcium release channel lesions in doxorubicin-induced cardiomyopathy. (1314436)
1992
44
Chronic doxorubicin induced cardiomyopathy in rabbits: mechanical, intracellular action potential, and beta adrenergic characteristics of the failing myocardium. (2170016)
1990
45
Role of (+-)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane (ICRF-187) in modulating free radical scavenging enzymes in doxorubicin-induced cardiomyopathy. (2116226)
1990
46
Heart transplantation in a child with doxorubicin-induced cardiomyopathy. (3054552)
1988
47
Role of phospholipase in the genesis of doxorubicin-induced cardiomyopathy in rats. (3815335)
1987
48
Lower incidence of doxorubicin-induced cardiomyopathy by once-a-week low-dose administration. (3513506)
1986
49
Prospective evaluation of doxorubicin-induced cardiomyopathy resulting from postsurgical adjuvant treatment of patients with soft tissue sarcomas. (6850545)
1983
50
Prospective randomized study of the role of N-acetyl cysteine in reversing doxorubicin-induced cardiomyopathy. (7165010)
1982

Genetic Variations for Doxorubicin Induced Cardiomyopathy

Expression for genes affiliated with Doxorubicin Induced Cardiomyopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Doxorubicin Induced Cardiomyopathy

Search GEO for disease gene expression data for Doxorubicin Induced Cardiomyopathy.

Pathways for genes affiliated with Doxorubicin Induced Cardiomyopathy

Sources:
52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 54Reactome, 60Tocris Bioscience
See all sources

Pathways related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9HGF, EPOR
29.8HGF, MET
3
Hide members
9.7EPHB2, HGF
49.4GATA4, MAPK14
5
Hide members
9.2EPHB2, MAPK14
6
Hide members
9.2HGF, GATA4, EPHB2, EPOR
79.2HGF, MET, EGFR
89.2HGF, MET, EGFR
99.2EGFR, MET, HGF
10
Hide members
9.1EPOR, EGFR, EDN1
11
Hide members
8.9HGF, BAX, MAPK14
12
Hide members
8.8MAPK14, EGFR, GATA4
138.7BAX, EGFR, MET, HGF
148.7BAX, EGFR, MET, HGF
15
Hide members
8.7MAPK14, EGFR, MET
168.4HGF, CSF3, MET, EGFR, EPOR
178.3MAPK14, EGFR, MET, HGF
18
Translation Insulin regulation of translation
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8.3HGF, MET, EGFR, MAPK14
19
Development Endothelin-1/EDNRA signaling
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8.3MAPK14, EGFR, EDN1, GATA4
20
Hide members
8.2EPHB2, MAPK14, EGFR, MET
21
Hide members
8.2MAPK14, BAX, EGFR, MET
22
Hide members
8.2HGF, CSF3, MET, EGFR, BAX
23
Hide members
8.0GATA4, EDN1, EGFR, MAPK14, EPOR
24
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8.0MET, EGFR, MAPK14, EPHB2, EPOR
25
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7.9HGF, MET, EGFR, BAX, MAPK14
26
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7.7HGF, MET, EGFR, MAPK14, EPHB2, EPOR
27
Hide members
7.7HGF, MET, EGFR, MAPK14, EPHB2, EPOR
28
Hide members
7.6HGF, MET, EGFR, BAX, MAPK14, EPOR
29
Hide members
6.7HGF, CSF3, MET, EGFR, BAX, MAPK14
30
Hide members
6.4HGF, CSF3, MET, EGFR, DES, BAX
31
Hide members
5.8EPOR, HGF, CSF3, EDN1, MET, EGFR

Compounds for genes affiliated with Doxorubicin Induced Cardiomyopathy

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6GATA4
2cycloheximide4510.6HGF
3indomethacin45 60 29 1112.9ECE1, CNR1, HGF
4pha 665752609.8HGF, MET
5pge2459.8EGFR, MET
6ccl445 2910.6DES, MET, HGF
7inositol459.6GATA4, HGF, MET, EPOR
8atrasentan459.5EGFR, EDN1
9su 11274609.5HGF, MET
10evodiamine459.2BAX, MAPK14
11agar459.1MET, EGFR, EPOR, HGF
12aloeemodin459.1BAX, MAPK14
133-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.0BAX, MAPK14, MET, DES
14serine458.9DES, EPOR, ECE1, MAPK14, GATA4
15adriamycin458.9MET, CSF3, BAX, HGF, DES
16n-formylmethionyl-leucylphenylalanine458.9CSF3, EPHB2, MAPK14
17matrigel458.9GATA4, HGF, MET, MAPK14
18suberoylanilide hydroxamic acid458.8MAPK14, BAX, EGFR
19apocynin45 609.8EGFR, EDN1, MAPK14
205fluorouracil458.8CSF3, HGF, EGFR, BAX
21geldanamycin45 50 60 1111.7HGF, MAPK14, EGFR, MET
22adpribose458.6DES, BAX, MAPK14, EGFR
23flavopiridol45 119.6EGFR, MAPK14, BAX
24superoxide45 249.6CSF3, EPHB2, MET, MAPK14
25thymidine45 249.6DES, HGF, CSF3, EDN1, MET, EPOR
26mg 13245 609.6BAX, EGFR, HGF, MAPK14
27wortmannin458.6MET, BAX, MAPK14, HGF, EPOR
28paraffin458.6EPOR, BAX, DES, EGFR, HGF, MET
29arginine458.4EDN1, CNR1, DES, EPOR, HGF, MET
30retinoid458.4HGF, GATA4, BAX, EGFR, MAPK14
31imatinib45 50 1110.3DES, EGFR, HGF, MAPK14, CSF3
32n acetylcysteine458.3MAPK14, EGFR, BAX, ECE1, HGF
33ag 1478458.2HGF, EDN1, MET, MAPK14, EGFR
34herbimycin a45 609.2EDN1, MET, MAPK14, EGFR, HGF
35paclitaxel45 50 1110.1MAPK14, BAX, EGFR, CSF3, HGF
36nitric oxide45 11 2410.0GATA4, DES, EPOR, ECE1, MAPK14, MET
37oxygen45 248.8EPOR, MAPK14, BAX, DES, MET, HGF
38calcium45 50 11 2410.8GATA4, DES, EDN1, EPOR, EPHB2, CNR1
39genistein45 29 60 2 11 2412.8MET, EDN1, MAPK14, EGFR, BAX, HGF
40ly294002457.8EPOR, CNR1, HGF, BAX, EGFR, MAPK14
41sb 20358045 608.7HGF, EPHB2, EGFR, BAX, MAPK14, EDN1
42phosphoinositide457.6EDN1, EGFR, MET, EPHB2, HGF, EPOR
43actinomycin d457.5HGF, ECE1, MET, MAPK14, EDN1, DES
44cisplatin45 50 60 1110.5EPOR, CSF3, HGF, MET, EGFR, BAX
45tyrosine457.2DES, EGFR, MET, HGF, MAPK14, EPOR
46phosphatidylinositol457.1EPOR, MAPK14, BAX, EGFR, MET, EPHB2
47pd 98,059457.1MET, EDN1, EPHB2, HGF, EGFR, ECE1
48doxorubicin45 50 119.0EGFR, BAX, DES, EPOR, HGF, MET
49retinoic acid45 247.9DES, CSF3, MET, EGFR, HGF, GATA4
50vegf456.4BAX, ECE1, MAPK14, DES, EGFR, EPOR

GO Terms for genes affiliated with Doxorubicin Induced Cardiomyopathy

Sources:
16Gene Ontology
See all sources

Biological processes related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.0MET, HGF
2myoblast proliferationGO:05145010.0MET, HGF
3regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.9HGF, MET
4regulation of systemic arterial blood pressure by endothelinGO:0031009.7EDN1, ECE1
5response to nicotineGO:0350949.7CNR1, EDN1
6regulation of vasoconstrictionGO:0192299.5ECE1, EDN1
7heart developmentGO:0075079.0EPOR, ECE1, EDN1
8activation of MAPK activityGO:0001879.0MAPK14, MET, HGF
9positive regulation of cell migrationGO:0303359.0HGF, EDN1, EGFR
10cell surface receptor signaling pathwayGO:0071668.3EDN1, MET, EGFR, MAPK14
11positive regulation of transcription from RNA polymerase II promoterGO:0459447.8MAPK14, HGF, CSF3, GATA4, MET, EGFR

Molecular functions related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NFAT protein bindingGO:0515259.3MAPK14, GATA4
2protein tyrosine kinase activityGO:0047138.8MET, EGFR, EPHB2
3identical protein bindingGO:0428028.5EPOR, BAX, DES, EGFR, HGF
4protein bindingGO:0055156.1GATA4, EDN1, MET, EGFR, DES, BAX

Products for genes affiliated with Doxorubicin Induced Cardiomyopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Doxorubicin Induced Cardiomyopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet