MCID: DXR001
MIFTS: 32

Doxorubicin Induced Cardiomyopathy malady

Cardiovascular diseases category

Summaries for Doxorubicin Induced Cardiomyopathy

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32MalaCards
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MalaCards: Doxorubicin Induced Cardiomyopathy is related to sarcoma and neuronitis. An important gene associated with Doxorubicin Induced Cardiomyopathy is GATA4 (GATA binding protein 4), and among its related pathways are CREB Pathway and Syndecan-1-mediated signaling events. The compounds estrogen and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

Aliases & Classifications for Doxorubicin Induced Cardiomyopathy

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42NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

doxorubicin induced cardiomyopathy 42


Related Diseases for Doxorubicin Induced Cardiomyopathy

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17GeneCards, 18GeneDecks
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Diseases related to Doxorubicin Induced Cardiomyopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.4DES, MET
2neuronitis10.1
3hypertrophic cardiomyopathy10.1
4vaginitis10.1
5wilms tumor10.0DES
6endometriosis10.0HGF
7hepatitis10.0HGF
8primary hyperoxaluria10.0EPOR
9fibrosarcoma10.0DES
10polycythemia10.0EPOR
11hemangioblastoma10.0EPOR
12gastrointestinal stromal tumor10.0DES
13amyotrophic lateral sclerosis10.0CNR1
14chordoma10.0DES
15glomerulonephritis10.0EPOR
16leiomyoma10.0DES
17polycythemia vera10.0EPOR
18teratoma10.0GATA4
19bladder carcinoma10.0BAX
20neurofibroma10.0MET
21alexander disease10.0DES
22multiple myeloma10.0CSF3
23leiomyosarcoma10.0DES
24liposarcoma10.0DES
25medulloblastoma10.0HGF, DES
26thyroid cancer10.0MET, EPOR
27rhabdomyosarcoma10.0MET, DES
28esophageal cancer10.0EGFR
29schizophrenia10.0CNR1
30hepatopulmonary syndrome10.0EDN1
31acute myocardial infarction10.0EDN1
32chondrosarcoma10.0MET, DES
33laryngeal benign neoplasm10.0EGFR
34meconium aspiration syndrome10.0EDN1
35salivary gland cancer10.0MET, HGF
36acute leukemia10.0EPOR, CSF3
37rheumatoid arthritis10.0MAPK14
38arthritis10.0MAPK14
39arteriosclerosis obliterans10.0HGF
40pulmonary fibrosis10.0EDN1, HGF
41hypertension10.0EDN1, ECE1
42myelodysplastic syndromes10.0CSF3, EPOR
43hepatitis c10.0MAPK14
44psoriasis10.0MAPK14
45coronary heart disease10.0EDN1
46malignant mesothelioma10.0HGF, DES, MET
47myeloid leukemia10.0BAX, CSF3
48hepatoblastoma10.0EPOR, MET, HGF
49synovial sarcoma10.0MET, DES, HGF
50glaucoma10.0CNR1, EDN1

Graphical network of the top 20 diseases related to Doxorubicin Induced Cardiomyopathy:



Diseases related to doxorubicin induced cardiomyopathy

Clinical Features for Doxorubicin Induced Cardiomyopathy

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Drugs & Therapeutics for Doxorubicin Induced Cardiomyopathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Doxorubicin Induced Cardiomyopathy

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Genetic Tests for Doxorubicin Induced Cardiomyopathy

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Anatomical Context for Doxorubicin Induced Cardiomyopathy

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Animal Models for Doxorubicin Induced Cardiomyopathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Doxorubicin Induced Cardiomyopathy:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537710.3ECE1
2MP:00053679.5EGFR, EDN1
3MP:00053809.4EPOR, GATA4, EDN1, ECE1
4MP:00053909.4ECE1, BAX, GATA4, CNR1
5MP:00053769.1DES, GATA4, MAPK14, CNR1
6MP:00036318.9EDN1, BAX, ECE1, GATA4, CNR1
7MP:00053798.9ECE1, BAX, MAPK14, GATA4
8MP:00053698.6ECE1, MAPK14, BAX, MET, GATA4
9MP:00030128.4HGF, MET, CNR1, EPOR, GATA4, EGFR
10MP:00053898.1GATA4, EGFR, BAX, CNR1, EPHB2
11MP:00053828.1ECE1, MET, EDN1, EGFR, EPHB2
12MP:00053708.0EPOR, MAPK14, EGFR, MET, HGF, GATA4
13MP:00053817.9GATA4, EGFR, ECE1, EPHB2, MET, EDN1
14MP:00053887.7MET, EPOR, EGFR, BAX, MAPK14, GATA4
15MP:00028737.5MAPK14, ECE1, MET, GATA4, EPOR, EDN1
16MP:00053977.1ECE1, EGFR, BAX, MAPK14, CSF3, EPOR
17MP:00053877.1EPOR, MAPK14, ECE1, EGFR, MET, CSF3
18MP:00053857.0HGF, EGFR, MET, DES, EDN1, GATA4
19MP:00053786.9EPHB2, MAPK14, BAX, EGFR, GATA4, HGF
20MP:00053846.9BAX, CNR1, EGFR, EPHB2, MAPK14, HGF
21MP:00107685.8MET, BAX, MAPK14, ECE1, EPOR, DES

Publications for Doxorubicin Induced Cardiomyopathy

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Genetic Variations for Doxorubicin Induced Cardiomyopathy

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Expression for genes affiliated with Doxorubicin Induced Cardiomyopathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Doxorubicin Induced Cardiomyopathy

Search GEO for disease gene expression data for Doxorubicin Induced Cardiomyopathy.

Pathways for genes affiliated with Doxorubicin Induced Cardiomyopathy

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome, 59Tocris Bioscience
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Pathways related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

(show all 31)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9HGF, EPOR
29.8HGF, MET
3
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9.7EPHB2, HGF
49.4GATA4, MAPK14
5
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9.2EPHB2, MAPK14
6
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9.2HGF, GATA4, EPHB2, EPOR
79.2HGF, MET, EGFR
89.2HGF, MET, EGFR
99.2EGFR, MET, HGF
10
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9.1EPOR, EGFR, EDN1
11
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8.9HGF, BAX, MAPK14
12
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8.8MAPK14, EGFR, GATA4
138.7BAX, EGFR, MET, HGF
148.7BAX, EGFR, MET, HGF
15
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8.7MAPK14, EGFR, MET
168.4HGF, CSF3, MET, EGFR, EPOR
178.3MAPK14, EGFR, MET, HGF
18
Translation Insulin regulation of translation
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8.3HGF, MET, EGFR, MAPK14
19
Development Endothelin-1/EDNRA signaling
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8.3MAPK14, EGFR, EDN1, GATA4
20
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8.2EPHB2, MAPK14, EGFR, MET
21
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8.2MAPK14, BAX, EGFR, MET
22
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8.2HGF, CSF3, MET, EGFR, BAX
23
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8.0GATA4, EDN1, EGFR, MAPK14, EPOR
24
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8.0MET, EGFR, MAPK14, EPHB2, EPOR
25
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7.9HGF, MET, EGFR, BAX, MAPK14
26
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7.7HGF, MET, EGFR, MAPK14, EPHB2, EPOR
27
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7.7HGF, MET, EGFR, MAPK14, EPHB2, EPOR
28
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7.6HGF, MET, EGFR, BAX, MAPK14, EPOR
29
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6.7HGF, CSF3, MET, EGFR, BAX, MAPK14
30
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6.4HGF, CSF3, MET, EGFR, DES, BAX
31
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5.8EPOR, HGF, CSF3, EDN1, MET, EGFR

Compounds for genes affiliated with Doxorubicin Induced Cardiomyopathy

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6GATA4
2cycloheximide4410.6HGF
3indomethacin44 59 28 1112.9ECE1, CNR1, HGF
4pha 665752599.8HGF, MET
5pge2449.8EGFR, MET
6ccl444 2810.6DES, MET, HGF
7inositol449.6GATA4, HGF, MET, EPOR
8atrasentan449.5EGFR, EDN1
9su 11274599.5HGF, MET
10evodiamine449.2BAX, MAPK14
11agar449.1MET, EGFR, EPOR, HGF
12aloeemodin449.1BAX, MAPK14
133-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.0BAX, MAPK14, MET, DES
14serine448.9DES, EPOR, ECE1, MAPK14, GATA4
15adriamycin448.9MET, CSF3, BAX, HGF, DES
16n-formylmethionyl-leucylphenylalanine448.9CSF3, EPHB2, MAPK14
17matrigel448.9GATA4, HGF, MET, MAPK14
18suberoylanilide hydroxamic acid448.8MAPK14, BAX, EGFR
19apocynin44 599.8EGFR, EDN1, MAPK14
205fluorouracil448.8CSF3, HGF, EGFR, BAX
21geldanamycin44 49 59 1111.7HGF, MAPK14, EGFR, MET
22adpribose448.6DES, BAX, MAPK14, EGFR
23flavopiridol44 119.6EGFR, MAPK14, BAX
24superoxide44 249.6CSF3, EPHB2, MET, MAPK14
25thymidine44 249.6DES, HGF, CSF3, EDN1, MET, EPOR
26mg 13244 599.6BAX, EGFR, HGF, MAPK14
27wortmannin448.6MET, BAX, MAPK14, HGF, EPOR
28paraffin448.6EPOR, BAX, DES, EGFR, HGF, MET
29arginine448.4EDN1, CNR1, DES, EPOR, HGF, MET
30retinoid448.4HGF, GATA4, BAX, EGFR, MAPK14
31imatinib44 49 1110.3DES, EGFR, HGF, MAPK14, CSF3
32n acetylcysteine448.3MAPK14, EGFR, BAX, ECE1, HGF
33ag 1478448.2HGF, EDN1, MET, MAPK14, EGFR
34herbimycin a44 599.2EDN1, MET, MAPK14, EGFR, HGF
35paclitaxel44 49 1110.1MAPK14, BAX, EGFR, CSF3, HGF
36nitric oxide44 11 2410.0GATA4, DES, EPOR, ECE1, MAPK14, MET
37oxygen44 248.8EPOR, MAPK14, BAX, DES, MET, HGF
38calcium44 49 11 2410.8GATA4, DES, EDN1, EPOR, EPHB2, CNR1
39genistein44 28 59 2 11 2412.8MET, EDN1, MAPK14, EGFR, BAX, HGF
40ly294002447.8EPOR, CNR1, HGF, BAX, EGFR, MAPK14
41sb 20358044 598.7HGF, EPHB2, EGFR, BAX, MAPK14, EDN1
42phosphoinositide447.6EDN1, EGFR, MET, EPHB2, HGF, EPOR
43actinomycin d447.5HGF, ECE1, MET, MAPK14, EDN1, DES
44cisplatin44 49 59 1110.5EPOR, CSF3, HGF, MET, EGFR, BAX
45tyrosine447.2DES, EGFR, MET, HGF, MAPK14, EPOR
46phosphatidylinositol447.1EPOR, MAPK14, BAX, EGFR, MET, EPHB2
47pd 98,059447.1MET, EDN1, EPHB2, HGF, EGFR, ECE1
48doxorubicin44 49 119.0EGFR, BAX, DES, EPOR, HGF, MET
49retinoic acid44 247.9DES, CSF3, MET, EGFR, HGF, GATA4
50vegf446.4BAX, ECE1, MAPK14, DES, EGFR, EPOR

GO Terms for genes affiliated with Doxorubicin Induced Cardiomyopathy

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16Gene Ontology
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Biological processes related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of hydrogen peroxide-mediated programmed cell deathGO:190129910.0MET, HGF
2myoblast proliferationGO:05145010.0MET, HGF
3regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.9HGF, MET
4regulation of systemic arterial blood pressure by endothelinGO:0031009.7EDN1, ECE1
5response to nicotineGO:0350949.7CNR1, EDN1
6regulation of vasoconstrictionGO:0192299.5ECE1, EDN1
7heart developmentGO:0075079.0EPOR, ECE1, EDN1
8activation of MAPK activityGO:0001879.0MAPK14, MET, HGF
9positive regulation of cell migrationGO:0303359.0HGF, EDN1, EGFR
10cell surface receptor signaling pathwayGO:0071668.3EDN1, MET, EGFR, MAPK14
11positive regulation of transcription from RNA polymerase II promoterGO:0459447.8MAPK14, HGF, CSF3, GATA4, MET, EGFR

Molecular functions related to Doxorubicin Induced Cardiomyopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1NFAT protein bindingGO:0515259.3GATA4, MAPK14
2protein tyrosine kinase activityGO:0047138.8EPHB2, EGFR, MET
3identical protein bindingGO:0428028.5HGF, EGFR, DES, BAX, EPOR
4protein bindingGO:0055156.1EGFR, EPOR, EPHB2, MAPK14, BAX, HGF

Products for genes affiliated with Doxorubicin Induced Cardiomyopathy

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Sources for Doxorubicin Induced Cardiomyopathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet