GWD
MCID: DRC001
MIFTS: 43

Dracunculiasis (GWD) malady

Infectious diseases category

Summaries for Dracunculiasis

About this section
Sources:
8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. the female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. the worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards: Dracunculiasis, also known as guinea worm disease, is related to onchocerciasis and schistosomiasis, and has symptoms including restricted joint mobility/joint stiffness/ankylosis, severe allergic reaction/atopy and gangrena/necrosis. An important gene associated with Dracunculiasis is PRSS21 (protease, serine, 21 (testisin)). The drug thiabendazole has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast.

CDC:3 The program has made great strides from 3.5 million cases annually in the mid-1980s to 542 cases in 2012. In 2013, progress toward global Guinea worm disease eradication has accelerated. During January–June 2013, only 89 cases were reported worldwide, a 77% reduction in cases from the same period in 2012. Global eradication is within reach.

Wikipedia:63 Dracunculiasis, also called guinea worm disease (GWD), is an infection by the guinea worm. A person... more...

Aliases & Classifications for Dracunculiasis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
dracunculiasis:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

dracunculiasis 8 42 10 48 60
guinea worm disease 42 48
parasitic infection caused by dracunculus medinensis 42
infection by dracunculus medinensis 8
guinea worm infection 42
medina worm disease 48
dracunculosis 48
dracontiasis 8
medinensis 48
gwd 42


External Ids:

Disease Ontology8 DOID:14418
MeSH34 D004320
NCIt39 C84677
ICD9CM27 125.7
MESH via Orphanet35 D004320
SNOMED-CT56 48874008, 396334002
ICD10 via Orphanet26 B72
SNOMED-CT via Orphanet57 396334002
UMLS via Orphanet61 C0013100
ICD1025 B72

Related Diseases for Dracunculiasis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1onchocerciasis10.2
2schistosomiasis10.2
3trachoma10.1
4filariasis10.1
5smallpox10.1
6pleurisy10.0
7trichuriasis10.0
8tungiasis10.0
9yellow fever10.0
10typhoid fever10.0
11scurvy10.0
12malaria10.0
13loiasis10.0ONECUT3
14urethritis10.0
15ascariasis10.0
16breast disease10.0
17dermatitis10.0
18poliomyelitis10.0

Graphical network of diseases related to Dracunculiasis:



Diseases related to dracunculiasis

Clinical Features for Dracunculiasis

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 15)
  • restricted joint mobility/joint stiffness/ankylosis
  • severe allergic reaction/atopy
  • gangrena/necrosis
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • arthritis/synovitis/synovial proliferation
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • cutaneous rash
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • fever/chilling
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • chronic skin infection/ulcerations/ulcers/cancrum

Drugs & Therapeutics for Dracunculiasis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Dracunculiasis

Drug clinical trials:

Search ClinicalTrials for Dracunculiasis

Search NIH Clinical Center for Dracunculiasis

Search CenterWatch for Dracunculiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Dracunculiasis

About this section

Anatomical Context for Dracunculiasis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Dracunculiasis:

32
Skin, Bone, Breast, Testes, Spinal cord

Animal Models for Dracunculiasis or affiliated genes

About this section

Publications for Dracunculiasis

About this section
Sources:
50PubMed
See all sources

Articles related to Dracunculiasis:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Monthly report on dracunculiasis cases, Januarya89December 2012. (23540052)
2013
2
Monthly report on dracunculiasis cases, Januarya89September 2013. (24319785)
2013
3
Monthly report on dracunculiasis cases, January 2013 a89 first month with zero cases. (23544240)
2013
4
Monthly report on dracunculiasis cases, January a89 February 2013. (23586140)
2013
5
Monthly report on dracunculiasis cases, January-December 2011. (24340396)
2012
6
Monthly report on dracunculiasis cases, Januarya89April 2012. (22741194)
2012
7
Dracunculiasis eradication--global surveillance summary, 2011. (24340405)
2012
8
Monthly report on dracunculiasis cases, January 2012. (22474715)
2012
9
Dracunculiasis of the breast: radiological manifestations of a rare disease. (23372866)
2012
10
Monthly report on dracunculiasis cases, Januarya89September 2012. (23139956)
2012
11
Monthly report on dracunculiasis cases, January-March 2012. (24340406)
2012
12
Monthly report on dracunculiasis cases, Januarya89October 2011. (22180899)
2011
13
Monthly report on dracunculiasis cases, Januarya89April 2011. (21706910)
2011
14
Monthly report on dracunculiasis cases, Januarya89May 2011. (21800469)
2011
15
Monthly report on dracunculiasis cases, Januarya89March 2011. (21661273)
2011
16
Monthly report on dracunculiasis cases, Januarya89September 2010. (21140597)
2010
17
Progress toward global eradication of dracunculiasis, January 2009-June 2010. (20881936)
2010
18
Dracunculiasis eradication - global surveillance summary, 2009. (20449943)
2010
19
Nigeria's triumph: dracunculiasis eradicated. (20682859)
2010
20
Dracunculiasis. An incidental diagnosis in a Saudi female. (17768477)
2007
21
Dracunculiasis eradication in endemic French-speaking African countries. (12795061)
2003
22
Dracunculiasis eradication: case definition, surveillance and performance indicators. (14526666)
2003
23
Dracunculiasis eradication in selected African countries. (11810728)
2002
24
From the Centers for Disease Control and Prevention. Progress toward global dracunculiasis eradication, June 2002. (12481761)
2002
25
Dracunculiasis: Ethiopia and Uganda. (12132130)
2002
26
Dracunculiasis eradication. Global surveillance summary, 2001. (12037944)
2002
27
Progress toward poliomyelitis and dracunculiasis eradication--Sudan, 1999-2000. (11411832)
2001
28
From the Centers for Disease Control and Prevention. Imported dracunculiasis--United States, 1995 and 1997. (9555742)
1998
29
Dracunculiasis. Certification of eradication. (9046862)
1997
30
Immunodiagnosis of early dracunculiasis. (8778178)
1996
31
Dracunculiasis. Programme review meeting of French-speaking endemic countries. (8961809)
1996
32
The impact of dracunculiasis on the nutritional status of children in South Kordofan, Sudan. (8893952)
1996
33
Dracunculiasis eradication: March 1994 update. (7856820)
1995
34
Dracunculiasis. (7718446)
1995
35
Eradication of dracunculiasis from Pakistan. (7651010)
1995
36
Dracunculiasis. Global surveillance summary, 1991. (1533783)
1992
37
Dracunculiasis in Jodhpur district: studies on some epidemiological and parasitological aspects. (1344951)
1992
38
Dracunculiasis. Fourth Regional Conference on Dracunculiasis in Africa. (1355353)
1992
39
Surveillance for dracunculiasis, 1981-1991. (1532630)
1992
40
Dracunculiasis. (1533147)
1992
41
Prevalence of dracunculiasis among Nigerian school children as an index of prevalence in their communities of origin. (1463362)
1992
42
Update: dracunculiasis eradication--Pakistan, 1990. (1824605)
1991
43
Dracunculiasis. (1830487)
1991
44
Dracunculiasis. (1980420)
1990
45
Dracunculiasis eradication: target 1995. (2145779)
1990
46
The prevalence and endemicity of dracunculiasis in Akowide village, Oyo State, Nigeria. (2143372)
1990
47
Synthetic-fibre filters for preventing dracunculiasis: 100 versus 200 micrometres pore size. (2976542)
1988
48
A note on the relative merits of metronidazole and mebendazole against dracunculiasis in the field. (6234348)
1983
49
Program to eradicate dracunculiasis--India. (6457244)
1981
50
Dracunculus and dracunculiasis. (4252302)
1971

Genetic Variations for Dracunculiasis

About this section

Expression for genes affiliated with Dracunculiasis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dracunculiasis

Search GEO for disease gene expression data for Dracunculiasis.

Pathways for genes affiliated with Dracunculiasis

About this section

Compounds for genes affiliated with Dracunculiasis

About this section

GO Terms for genes affiliated with Dracunculiasis

About this section

Products for genes affiliated with Dracunculiasis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dracunculiasis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet