MCID: DRC001
MIFTS: 38

Dracunculiasis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Dracunculiasis

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 2CDC, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Dracunculiasis:

Name: Dracunculiasis 11 46 13 52 2 37 66
Guinea Worm Disease 46 52 2
Parasitic Infection Caused by Dracunculus Medinensis 46
Infection by Dracunculus Medinensis 11
Guinea Worm Infection 46
 
Medina Worm Disease 52
Dracunculosis 52
Dracontiasis 11
Medinensis 52
Gwd 46

Characteristics:

Orphanet epidemiological data:

52
dracunculiasis:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:14418
ICD1028 B72
ICD9CM30 125.7
MeSH37 D004320
NCIt43 C84677
SNOMED-CT60 396334002, 48874008
Orphanet52 ORPHA231
ICD10 via Orphanet29 B72
MESH via Orphanet38 D004320
UMLS via Orphanet67 C0013100

Summaries for Dracunculiasis

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Disease Ontology:11 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. the female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. the worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards based summary: Dracunculiasis, also known as guinea worm disease, is related to schistosomiasis and onchocerciasis, and has symptoms including skin rash, pruritus and diarrhea. An important gene associated with Dracunculiasis is SETDB1 (SET Domain Bifurcated 1). The drug thiabendazole has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast.

CDC:2 The program has made great strides from 3.5 million cases annually in the mid-1980s to 126 cases in 2014.  In 2015, only 22 cases were reported worldwide—a 83% reduction in cases from the previous year. Global eradication is within reach.

Wikipedia:69 Dracunculiasis, also called Guinea-worm disease (GWD), is an infection by the Guinea worm. A person... more...

Related Diseases for Dracunculiasis

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Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis10.1
2onchocerciasis10.1
3smallpox10.1
4trachoma10.0
5pleurisy10.0
6malaria9.9
7scurvy9.9
8trichuriasis9.9
9typhoid fever9.9
10yellow fever9.9
11filariasis9.8
12urethritis9.8
13dermatitis9.8
14ascariasis9.8
15poliomyelitis9.8
16glossopharyngeal neuralgia6.0AVPR2, HM13, HPGDS, MANEA, ONECUT3, PPP1R14A

Graphical network of diseases related to Dracunculiasis:



Diseases related to dracunculiasis

Symptoms for Dracunculiasis

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Symptoms:

 52 (show all 15)
  • skin rash
  • pruritus
  • arthritis
  • flexion contracture
  • limitation of joint mobility
  • subcutaneous nodule
  • diarrhea
  • nausea and vomiting
  • abnormal blistering of the skin
  • low-grade fever
  • immunologic hypersensitivity
  • cellulitis
  • gangrene
  • recurrent cutaneous abscess formation
  • skin ulcer

HPO human phenotypes related to Dracunculiasis:

(show all 14)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 pruritus hallmark (90%) HP:0000989
3 diarrhea hallmark (90%) HP:0002014
4 nausea and vomiting hallmark (90%) HP:0002017
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 abnormal blistering of the skin hallmark (90%) HP:0008066
7 skin ulcer hallmark (90%) HP:0200042
8 arthritis typical (50%) HP:0001369
9 limitation of joint mobility typical (50%) HP:0001376
10 immunologic hypersensitivity typical (50%) HP:0100326
11 cellulitis typical (50%) HP:0100658
12 recurrent cutaneous abscess formation typical (50%) HP:0100838
13 flexion contracture occasional (7.5%) HP:0001371
14 gangrene occasional (7.5%) HP:0100758

Drugs & Therapeutics for Dracunculiasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Dracunculiasis

Inferred drug relations via UMLS66/NDF-RT44:


Cochrane evidence based reviews: dracunculiasis

Genetic Tests for Dracunculiasis

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Anatomical Context for Dracunculiasis

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MalaCards organs/tissues related to Dracunculiasis:

34
Skin, Bone, Breast, Testes, Spinal cord

Animal Models for Dracunculiasis or affiliated genes

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Publications for Dracunculiasis

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Articles related to Dracunculiasis:

(show top 50)    (show all 320)
idTitleAuthorsYear
1
Dracunculiasis eradication: global surveillance summary, 2014. (25958417)
2015
2
Monthly report on dracunculiasis cases, January- September 2015. (26591027)
2015
3
Dracunculiasis eradication--global surveillance summary, 2013. (24864343)
2014
4
Monthly report on dracunculiasis cases, Januarya89December 2012. (23540052)
2013
5
Dracunculiasis eradication: and now, South Sudan. (23843492)
2013
6
Monthly report on dracunculiasis cases, Januarya89September 2013. (24319785)
2013
7
Monthly report on dracunculiasis cases, January a89 August 2013. (24159669)
2013
8
Why is dracunculiasis eradication taking so long? (22520367)
2012
9
Monthly report on dracunculiasis cases, Januarya89June 2012. (23061105)
2012
10
Monthly report on dracunculiasis cases, Januarya89October 2011. (22180899)
2011
11
Monthly report on dracunculiasis cases, Januarya89April 2011. (21706910)
2011
12
Renewed transmission of dracunculiasis--Chad, 2010. (21659983)
2011
13
Monthly report on dracunculiasis cases, Januarya89May 2011. (21800469)
2011
14
Monthly report on dracunculiasis cases, Januarya89March 2011. (21661273)
2011
15
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
16
Editorial: Dracunculiasis eradication by 2009: will endemic countries meet the target? (18076547)
2007
17
Persistence of dracunculiasis in northern Mali: the case of the Gao region. (19617070)
2005
18
Dracunculiasis eradication. Global surveillance summary, 2004. (15934399)
2005
19
Progress toward global eradication of dracunculiasis, 2002-2003. (15385918)
2004
20
Dracunculiasis (guinea-worm disease) eradication. (15139173)
2004
21
Dracunculiasis eradication in endemic French-speaking African countries. (12795061)
2003
22
Dracunculiasis eradication. Khartoum Declaration on guinea-worm eradication, Sudan, 2002. (12037943)
2002
23
From the Centers for Disease Control and Prevention. Progress toward global dracunculiasis eradication, June 2002. (12481761)
2002
24
Imported dracunculiasis--United States, 1995 and 1997. (9704542)
1998
25
Dracunculiasis. Certification of transmission-free status. (9542462)
1998
26
Imported dracunculiasis--United States, 1995 and 1997. (9551880)
1998
27
Dracunculiasis. Global surveillance summary, 1997. (9594666)
1998
28
From the Centers for Disease Control and Prevention. Imported dracunculiasis--United States, 1995 and 1997. (9555742)
1998
29
Dracunculiasis eradication: almost a reality. (9311632)
1997
30
Progress in dracunculiasis eradication. (9478167)
1997
31
Dracunculiasis. (8776191)
1996
32
Dracunculiasis. Global surveillance summary, 1994. (7786714)
1995
33
Dracunculiasis eradication. Update. (7893596)
1995
34
Dracunculiasis eradication. Update: Mali and Niger, 1993. (8193008)
1994
35
Dracunculiasis causing urethral fistula. (8199842)
1994
36
Dracunculiasis. Global surveillance summary, 1993. (8198959)
1994
37
Update: dracunculiasis eradication--Mali and Niger, 1993. (8295627)
1994
38
Dracunculiasis. Global surveillance summary, 1991. (1533783)
1992
39
Dracunculiasis in Jodhpur district: studies on some epidemiological and parasitological aspects. (1344951)
1992
40
Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. (1835675)
1991
41
How the USSR rid itself of dracunculiasis. (1835391)
1991
42
Dracunculiasis. (1980420)
1990
43
Dracunculiasis eradication: target 1995. (2145779)
1990
44
Surveillance: the foundation for control and elimination of dracunculiasis in Africa. (2533584)
1989
45
Dracunculiasis in some Arkansas carnivores. (6238141)
1984
46
Dracunculiasis in Igbon, Oyo State, Nigeria. (6240544)
1984
47
Guinea worm (Dracunculiasis) and the International Water Supply and Sanitation Decade. (6454836)
1981
48
Scrotal dracunculiasis. (4239003)
1969
49
Efficacy of thiabendazole in the treatment of dracunculiasis. (4244200)
1969
50
A Case of Dracunculiasis (Guinea-worm) in Nairobi. (20788181)
1953

Variations for Dracunculiasis

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Expression for genes affiliated with Dracunculiasis

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Search GEO for disease gene expression data for Dracunculiasis.

Pathways for genes affiliated with Dracunculiasis

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GO Terms for genes affiliated with Dracunculiasis

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Biological processes related to Dracunculiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homotetramerizationGO:00512899.3HM13, SAMHD1

Sources for Dracunculiasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet