GWD
MCID: DRC001
MIFTS: 43

Dracunculiasis (GWD) malady

Rare diseases, Infectious diseases categories
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Summaries for Dracunculiasis

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Sources:
8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. the female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. the worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards: Dracunculiasis, also known as guinea worm disease, is related to onchocerciasis and schistosomiasis, and has symptoms including restricted joint mobility/joint stiffness/ankylosis, severe allergic reaction/atopy and gangrena/necrosis. An important gene associated with Dracunculiasis is PRSS21 (protease, serine, 21 (testisin)). The drug thiabendazole has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast.

CDC:4 The program has made great strides from 3.5 million cases annually in the mid-1980s to 542 cases in 2012.  In 2013, only 148 cases were reported worldwide—a 73% reduction in cases from the previous year. Global eradication is within reach.

Wikipedia:65 Dracunculiasis, also called guinea worm disease (GWD), is an infection by the guinea worm. A person... more...

Aliases & Classifications for Dracunculiasis

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

49
dracunculiasis:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

dracunculiasis 8 43 10 49 62
guinea worm disease 43 49
parasitic infection caused by dracunculus medinensis 43
infection by dracunculus medinensis 8
guinea worm infection 43
medina worm disease 49
dracunculosis 49
dracontiasis 8
medinensis 49
gwd 43


External Ids:

Disease Ontology8 DOID:14418
MeSH35 D004320
ICD9CM27 125.7
NCIt40 C84677
MESH via Orphanet36 D004320
SNOMED-CT58 396334002, 48874008
ICD10 via Orphanet26 B72
SNOMED-CT via Orphanet59 396334002
UMLS via Orphanet63 C0013100
ICD1025 B72

Related Diseases for Dracunculiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1onchocerciasis10.2
2schistosomiasis10.2
3trachoma10.2
4filariasis10.2
5smallpox10.2
6pleurisy10.1
7trichuriasis10.0
8yellow fever10.0
9scurvy10.0
10tungiasis10.0
11typhoid fever10.0
12malaria10.0
13ascariasis10.0
14urethritis10.0
15dermatitis10.0
16poliomyelitis10.0
17helminthiasis10.0
18blindness10.0

Graphical network of diseases related to Dracunculiasis:



Diseases related to dracunculiasis

Symptoms for Dracunculiasis

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49Orphanet
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Symptoms:

49 (show all 15)
  • restricted joint mobility/joint stiffness/ankylosis
  • severe allergic reaction/atopy
  • gangrena/necrosis
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • arthritis/synovitis/synovial proliferation
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • cutaneous rash
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • fever/chilling
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • chronic skin infection/ulcerations/ulcers/cancrum

Drugs & Therapeutics for Dracunculiasis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Dracunculiasis

Search NIH Clinical Center for Dracunculiasis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Dracunculiasis

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Anatomical Context for Dracunculiasis

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33MalaCards
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MalaCards organs/tissues related to Dracunculiasis:

33
Skin, Bone, Breast, Testes, Spinal cord

Animal Models for Dracunculiasis or affiliated genes

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Publications for Dracunculiasis

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Sources:
52PubMed
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Articles related to Dracunculiasis:

(show top 50)    (show all 289)
idTitleAuthorsYear
1
Monthly report on dracunculiasis cases, Januarya89December 2012. (23540052)
2013
2
Dracunculiasis eradication: and now, South Sudan. (23843492)
2013
3
Monthly report on dracunculiasis cases, January-December 2011. (24340396)
2012
4
Why is dracunculiasis eradication taking so long? (22520367)
2012
5
Monthly report on dracunculiasis cases, Januarya89April 2012. (22741194)
2012
6
Dracunculiasis: two cases with rare presentations. (23378712)
2012
7
Monthly report on dracunculiasis cases, Januarya89June 2012. (23061105)
2012
8
Monthly report on dracunculiasis cases, Januarya89October 2011. (22180899)
2011
9
Monthly report on dracunculiasis cases, Januarya89April 2011. (21706910)
2011
10
Renewed transmission of dracunculiasis--Chad, 2010. (21659983)
2011
11
Dracunculiasis: a candidate for eradication. (20415107)
2010
12
Monthly report on dracunculiasis cases, January 2009-February 2010. (20414988)
2010
13
Monthly report on dracunculiasis cases, January-July 2010. (20830853)
2010
14
Progress in dracunculiasis eradication in Oyo state, South-west Nigeria: a case study. (21327143)
2010
15
Monthly report on dracunculiasis cases, January-April 2010. (20583386)
2010
16
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
17
Monthly report on dracunculiasis cases, January-August 2009. (19894346)
2009
18
Dracunculiasis eradication. (15227956)
2004
19
Progress toward global eradication of dracunculiasis, 2002-2003. (15385918)
2004
20
Control of endemic dracunculiasis in Ebonyi state, south-eastern Nigeria. (14626906)
2003
21
Dracunculiasis eradication. Khartoum Declaration on guinea-worm eradication, Sudan, 2002. (12037943)
2002
22
Dracunculiasis eradication in selected African countries. (11810728)
2002
23
Progress toward poliomyelitis and dracunculiasis eradication--Sudan, 1999-2000. (11411832)
2001
24
Dracunculiasis eradication: delayed, not denied. (10813467)
2000
25
Imported dracunculiasis--United States, 1995 and 1997. (9704542)
1998
26
Dracunculiasis. Certification of transmission-free status. (9542462)
1998
27
Imported dracunculiasis--United States, 1995 and 1997. (9551880)
1998
28
Dracunculiasis eradication: almost a reality. (9311632)
1997
29
The acceptability and effectiveness of a polyester drinking-water filter in a dracunculiasis-endemic village in northern region, Ghana. (9447778)
1997
30
Dracunculiasis. (8776191)
1996
31
Update: dracunculiasis eradication--Ghana and Nigeria, 1994. (7870023)
1995
32
Dracunculiasis eradication. Update: Mali and Niger, 1993. (8193008)
1994
33
Dracunculiasis eradication. Update. (7917882)
1994
34
Update: dracunculiasis eradication--Ghana and Nigeria, 1993. (8159156)
1994
35
Dracunculiasis causing urethral fistula. (8199842)
1994
36
Dracunculiasis in Burkina Faso: results of a national survey. (8254714)
1993
37
An outbreak of dracunculiasis in central Sudan. (8122918)
1993
38
Dracunculiasis. Global surveillance summary, 1991. (1533783)
1992
39
Dracunculiasis in Jodhpur district: studies on some epidemiological and parasitological aspects. (1344951)
1992
40
Progress towards the eradication of dracunculiasis. (1533421)
1992
41
Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. (1835675)
1991
42
Epidemiology of dracunculiasis and its socio-economic impact in a village in south-west Nigeria. (1838698)
1991
43
A strategy to speed the eradication of dracunculiasis. (1835392)
1991
44
Update: dracunculiasis eradication--Ghana and Nigeria, 1990. (1826338)
1991
45
Dracunculiasis. First national programme managers' meeting. (1835884)
1991
46
Dracunculiasis. (2145961)
1990
47
Human case of dracunculiasis in Japan. (2936260)
1986
48
Dracunculiasis in some Arkansas carnivores. (6238141)
1984
49
Metronidazole in dracunculiasis. A preliminary report. (4247716)
1970
50
Scrotal dracunculiasis. (4239003)
1969

Variations for Dracunculiasis

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Expression for genes affiliated with Dracunculiasis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dracunculiasis

Search GEO for disease gene expression data for Dracunculiasis.

Pathways for genes affiliated with Dracunculiasis

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Compounds for genes affiliated with Dracunculiasis

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GO Terms for genes affiliated with Dracunculiasis

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Products for genes affiliated with Dracunculiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dracunculiasis

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet