MCID: DRC001
MIFTS: 36

Dracunculiasis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Dracunculiasis

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Dracunculiasis:

Name: Dracunculiasis 11 47 53 2 38 13 67
Guinea Worm Disease 47 53 2
Parasitic Infection Caused by Dracunculus Medinensis 47
Infection by Dracunculus Medinensis 11
Guinea Worm Infection 47
 
Medina Worm Disease 53
Dracunculosis 53
Dracontiasis 11
Medinensis 53
Gwd 47

Characteristics:

Orphanet epidemiological data:

53
dracunculiasis:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:14418
ICD1029 B72
ICD9CM31 125.7
MeSH38 D004320
NCIt44 C84677
SNOMED-CT61 396334002, 48874008
Orphanet53 ORPHA231
UMLS via Orphanet68 C0013100
ICD10 via Orphanet30 B72
MESH via Orphanet39 D004320

Summaries for Dracunculiasis

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Disease Ontology:11 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards based summary: Dracunculiasis, also known as guinea worm disease, is related to schistosomiasis and onchocerciasis, and has symptoms including skin rash, pruritus and diarrhea. An important gene associated with Dracunculiasis is SETDB1 (SET Domain Bifurcated 1). The drug thiabendazole has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast.

CDC:2 The program has made great strides from 3.5 million cases annually in the mid-1980s to 126 cases in 2014.  In 2015, only 22 cases were reported worldwide—a 83% reduction in cases from the previous year. Global eradication is within reach.

Wikipedia:70 Dracunculiasis, also called Guinea-worm disease (GWD), is an infection by the Guinea worm. A person... more...

Related Diseases for Dracunculiasis

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Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis10.0
2onchocerciasis9.9
3smallpox9.9
4trachoma9.8
5pleurisy9.8
6malaria9.7
7scurvy9.7
8trichuriasis9.7
9typhoid fever9.7
10yellow fever9.7
11filariasis9.7
12urethritis9.7
13dermatitis9.7
14ascariasis9.7
15poliomyelitis9.7
16muscular atrophy9.7
17glossopharyngeal neuralgia6.4AVPR2, HM13, HPGDS, MANEA, ONECUT3, PPP1R14A

Graphical network of diseases related to Dracunculiasis:



Diseases related to dracunculiasis

Symptoms for Dracunculiasis

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Human phenotypes related to Dracunculiasis:

 63 53 (show all 16)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 skin rash63 53 hallmark (90%) Very frequent (99-80%) HP:0000988
2 pruritus63 53 hallmark (90%) Very frequent (99-80%) HP:0000989
3 diarrhea63 53 hallmark (90%) Very frequent (99-80%) HP:0002014
4 nausea and vomiting63 53 hallmark (90%) Very frequent (99-80%) HP:0002017
5 abnormality of temperature regulation63 hallmark (90%) HP:0004370
6 abnormal blistering of the skin63 53 hallmark (90%) Very frequent (99-80%) HP:0008066
7 skin ulcer63 53 hallmark (90%) Very frequent (99-80%) HP:0200042
8 arthritis63 53 typical (50%) Frequent (79-30%) HP:0001369
9 limitation of joint mobility63 53 typical (50%) Frequent (79-30%) HP:0001376
10 immunologic hypersensitivity63 53 typical (50%) Frequent (79-30%) HP:0100326
11 cellulitis63 53 typical (50%) Frequent (79-30%) HP:0100658
12 recurrent cutaneous abscess formation63 53 typical (50%) Frequent (79-30%) HP:0100838
13 flexion contracture63 53 occasional (7.5%) Occasional (29-5%) HP:0001371
14 gangrene63 53 occasional (7.5%) Occasional (29-5%) HP:0100758
15 subcutaneous nodule53 Very frequent (99-80%)
16 low-grade fever53 Very frequent (99-80%)

Drugs & Therapeutics for Dracunculiasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Dracunculiasis

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: dracunculiasis

Genetic Tests for Dracunculiasis

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Anatomical Context for Dracunculiasis

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MalaCards organs/tissues related to Dracunculiasis:

35
Skin, Bone, Breast, Testes, Spinal cord

Animal Models for Dracunculiasis or affiliated genes

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Publications for Dracunculiasis

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Articles related to Dracunculiasis:

(show top 50)    (show all 321)
idTitleAuthorsYear
1
Progress Toward Global Eradication of Dracunculiasis -January 2015-June 2016. (27736840)
2016
2
Dracunculiasis eradication: global surveillance summary, 2014. (25958417)
2015
3
Monthly report on dracunculiasis cases, January- September 2015. (26591027)
2015
4
Dracunculiasis eradication--global surveillance summary, 2013. (24864343)
2014
5
Monthly report on dracunculiasis cases, Januarya89December 2012. (23540052)
2013
6
Dracunculiasis eradication: and now, South Sudan. (23843492)
2013
7
Monthly report on dracunculiasis cases, Januarya89September 2013. (24319785)
2013
8
Monthly report on dracunculiasis cases, January a89 August 2013. (24159669)
2013
9
Why is dracunculiasis eradication taking so long? (22520367)
2012
10
Monthly report on dracunculiasis cases, Januarya89June 2012. (23061105)
2012
11
Monthly report on dracunculiasis cases, Januarya89October 2011. (22180899)
2011
12
Monthly report on dracunculiasis cases, Januarya89April 2011. (21706910)
2011
13
Renewed transmission of dracunculiasis--Chad, 2010. (21659983)
2011
14
Monthly report on dracunculiasis cases, Januarya89May 2011. (21800469)
2011
15
Monthly report on dracunculiasis cases, Januarya89March 2011. (21661273)
2011
16
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
17
Editorial: Dracunculiasis eradication by 2009: will endemic countries meet the target? (18076547)
2007
18
Persistence of dracunculiasis in northern Mali: the case of the Gao region. (19617070)
2005
19
Dracunculiasis eradication. Global surveillance summary, 2004. (15934399)
2005
20
Progress toward global eradication of dracunculiasis, 2002-2003. (15385918)
2004
21
Dracunculiasis (guinea-worm disease) eradication. (15139173)
2004
22
Dracunculiasis eradication. Khartoum Declaration on guinea-worm eradication, Sudan, 2002. (12037943)
2002
23
From the Centers for Disease Control and Prevention. Progress toward global dracunculiasis eradication, June 2002. (12481761)
2002
24
Imported dracunculiasis--United States, 1995 and 1997. (9704542)
1998
25
Dracunculiasis. Certification of transmission-free status. (9542462)
1998
26
Imported dracunculiasis--United States, 1995 and 1997. (9551880)
1998
27
Dracunculiasis. Global surveillance summary, 1997. (9594666)
1998
28
From the Centers for Disease Control and Prevention. Imported dracunculiasis--United States, 1995 and 1997. (9555742)
1998
29
Dracunculiasis eradication: almost a reality. (9311632)
1997
30
Progress in dracunculiasis eradication. (9478167)
1997
31
Dracunculiasis. (8776191)
1996
32
Dracunculiasis. Global surveillance summary, 1994. (7786714)
1995
33
Dracunculiasis eradication. Update. (7893596)
1995
34
Dracunculiasis eradication. Update: Mali and Niger, 1993. (8193008)
1994
35
Dracunculiasis causing urethral fistula. (8199842)
1994
36
Dracunculiasis. Global surveillance summary, 1993. (8198959)
1994
37
Update: dracunculiasis eradication--Mali and Niger, 1993. (8295627)
1994
38
Dracunculiasis. Global surveillance summary, 1991. (1533783)
1992
39
Dracunculiasis in Jodhpur district: studies on some epidemiological and parasitological aspects. (1344951)
1992
40
Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. (1835675)
1991
41
How the USSR rid itself of dracunculiasis. (1835391)
1991
42
Dracunculiasis. (1980420)
1990
43
Dracunculiasis eradication: target 1995. (2145779)
1990
44
Surveillance: the foundation for control and elimination of dracunculiasis in Africa. (2533584)
1989
45
Dracunculiasis in some Arkansas carnivores. (6238141)
1984
46
Dracunculiasis in Igbon, Oyo State, Nigeria. (6240544)
1984
47
Guinea worm (Dracunculiasis) and the International Water Supply and Sanitation Decade. (6454836)
1981
48
Scrotal dracunculiasis. (4239003)
1969
49
Efficacy of thiabendazole in the treatment of dracunculiasis. (4244200)
1969
50
A Case of Dracunculiasis (Guinea-worm) in Nairobi. (20788181)
1953

Variations for Dracunculiasis

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Expression for genes affiliated with Dracunculiasis

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Search GEO for disease gene expression data for Dracunculiasis.

Pathways for genes affiliated with Dracunculiasis

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GO Terms for genes affiliated with Dracunculiasis

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Biological processes related to Dracunculiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homotetramerizationGO:00512899.3HM13, SAMHD1

Sources for Dracunculiasis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet