GWD
MCID: DRC001
MIFTS: 45

Dracunculiasis (GWD) malady

Rare diseases, Infectious diseases categories
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Summaries for Dracunculiasis

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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. the female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. the worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards based summary: Dracunculiasis, also known as guinea worm disease, is related to onchocerciasis and schistosomiasis, and has symptoms including chronic skin infection/ulcerations/ulcers/cancrum, cutaneous rash and vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment. An important gene associated with Dracunculiasis is PRSS21 (protease, serine, 21 (testisin)). The drug thiabendazole has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast.

CDC:3 The program has made great strides from 3.5 million cases annually in the mid-1980s to 542 cases in 2012.  In 2013, only 148 cases were reported worldwide—a 73% reduction in cases from the previous year. Global eradication is within reach.

Wikipedia:65 Dracunculiasis, also called guinea worm disease (GWD), is an infection by the guinea worm. A person... more...

Aliases & Classifications for Dracunculiasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Dracunculiasis, Aliases & Descriptions:

Name: Dracunculiasis 8 42 10 48 62
Guinea Worm Disease 42 48 62
Infection by Dracunculus Medinensis 8 62
Guinea Worm Infection 42 62
Parasitic Infection Caused by Dracunculus Medinensis 42
 
Medina Worm Disease 48
Dracunculosis 48
Dracontiasis 8
Medinensis 48
Gwd 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
dracunculiasis:
Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:14418
MeSH34 D004320
NCIt39 C84677
ICD9CM27 125.7
SNOMED-CT57 48874008, 396334002
MESH via Orphanet35 D004320
ICD10 via Orphanet26 B72
UMLS via Orphanet63 C0013100
ICD1025 B72

Related Diseases for Dracunculiasis

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Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1onchocerciasis10.3
2schistosomiasis10.3
3trachoma10.2
4smallpox10.2
5pleurisy10.1
6malaria10.0
7trichuriasis10.0
8scurvy10.0
9typhoid fever10.0
10yellow fever10.0
11tungiasis10.0
12ascariasis10.0
13urethritis10.0
14dermatitis10.0
15filariasis10.0
16poliomyelitis10.0
17helminthiasis10.0
18blindness10.0

Graphical network of diseases related to Dracunculiasis:



Diseases related to dracunculiasis

Symptoms for Dracunculiasis

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Symptoms:

48 (show all 15)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • fever/chilling
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • severe allergic reaction/atopy
  • gangrena/necrosis
  • contractures/cramps/trismus/tetania/claudication/opisthotonos

HPO human phenotypes related to Dracunculiasis:

(show all 14)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 pruritus hallmark (90%) HP:0000989
3 diarrhea hallmark (90%) HP:0002014
4 nausea and vomiting hallmark (90%) HP:0002017
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 abnormal blistering of the skin hallmark (90%) HP:0008066
7 skin ulcer hallmark (90%) HP:0200042
8 arthritis typical (50%) HP:0001369
9 limitation of joint mobility typical (50%) HP:0001376
10 immunologic hypersensitivity typical (50%) HP:0100326
11 cellulitis typical (50%) HP:0100658
12 recurrent cutaneous abscess formation typical (50%) HP:0100838
13 flexion contracture occasional (7.5%) HP:0001371
14 gangrene occasional (7.5%) HP:0100758

Drugs & Therapeutics for Dracunculiasis

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Drug clinical trials:

Search ClinicalTrials for Dracunculiasis

Search NIH Clinical Center for Dracunculiasis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Dracunculiasis

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Anatomical Context for Dracunculiasis

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MalaCards organs/tissues related to Dracunculiasis:

32
Skin, Bone, Breast, Spinal cord, Testes

Animal Models for Dracunculiasis or affiliated genes

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Publications for Dracunculiasis

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Articles related to Dracunculiasis:

(show top 50)    (show all 302)
idTitleAuthorsYear
1
Monthly report on dracunculiasis cases, January a89- April 2014. (24864344)
2014
2
Monthly report on dracunculiasis cases, January 2014. (24707516)
2014
3
Monthly report on dracunculiasis cases, Januarya89December 2012. (23540052)
2013
4
Monthly report on dracunculiasis cases, January-December 2011. (24340396)
2012
5
Why is dracunculiasis eradication taking so long? (22520367)
2012
6
Monthly report on dracunculiasis cases, Januarya89April 2012. (22741194)
2012
7
Dracunculiasis: two cases with rare presentations. (23378712)
2012
8
Monthly report on dracunculiasis cases, Januarya89June 2012. (23061105)
2012
9
Monthly report on dracunculiasis cases, Januarya89October 2011. (22180899)
2011
10
Monthly report on dracunculiasis cases, Januarya89April 2011. (21706910)
2011
11
Renewed transmission of dracunculiasis--Chad, 2010. (21659983)
2011
12
Dracunculiasis: a candidate for eradication. (20415107)
2010
13
Monthly report on dracunculiasis cases, January 2009-February 2010. (20414988)
2010
14
Monthly report on dracunculiasis cases, January-July 2010. (20830853)
2010
15
Progress in dracunculiasis eradication in Oyo state, South-west Nigeria: a case study. (21327143)
2010
16
Monthly report on dracunculiasis cases, January-April 2010. (20583386)
2010
17
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
18
Monthly report on dracunculiasis cases, January-August 2009. (19894346)
2009
19
Dracunculiasis eradication. (15227956)
2004
20
Progress toward global eradication of dracunculiasis, 2002-2003. (15385918)
2004
21
Control of endemic dracunculiasis in Ebonyi state, south-eastern Nigeria. (14626906)
2003
22
Dracunculiasis eradication. Khartoum Declaration on guinea-worm eradication, Sudan, 2002. (12037943)
2002
23
Dracunculiasis eradication in selected African countries. (11810728)
2002
24
Progress toward poliomyelitis and dracunculiasis eradication--Sudan, 1999-2000. (11411832)
2001
25
Dracunculiasis eradication: delayed, not denied. (10813467)
2000
26
Imported dracunculiasis--United States, 1995 and 1997. (9704542)
1998
27
Dracunculiasis. Certification of transmission-free status. (9542462)
1998
28
Imported dracunculiasis--United States, 1995 and 1997. (9551880)
1998
29
Dracunculiasis eradication: almost a reality. (9311632)
1997
30
The acceptability and effectiveness of a polyester drinking-water filter in a dracunculiasis-endemic village in northern region, Ghana. (9447778)
1997
31
Dracunculiasis. (8776191)
1996
32
Update: dracunculiasis eradication--Ghana and Nigeria, 1994. (7870023)
1995
33
Dracunculiasis eradication. Update: Mali and Niger, 1993. (8193008)
1994
34
Dracunculiasis eradication. Update. (7917882)
1994
35
Update: dracunculiasis eradication--Ghana and Nigeria, 1993. (8159156)
1994
36
Dracunculiasis causing urethral fistula. (8199842)
1994
37
Dracunculiasis in Burkina Faso: results of a national survey. (8254714)
1993
38
An outbreak of dracunculiasis in central Sudan. (8122918)
1993
39
Dracunculiasis. Global surveillance summary, 1991. (1533783)
1992
40
Dracunculiasis in Jodhpur district: studies on some epidemiological and parasitological aspects. (1344951)
1992
41
Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. (1835675)
1991
42
Epidemiology of dracunculiasis and its socio-economic impact in a village in south-west Nigeria. (1838698)
1991
43
A strategy to speed the eradication of dracunculiasis. (1835392)
1991
44
Update: dracunculiasis eradication--Ghana and Nigeria, 1990. (1826338)
1991
45
Dracunculiasis. First national programme managers' meeting. (1835884)
1991
46
Dracunculiasis. (2145961)
1990
47
Human case of dracunculiasis in Japan. (2936260)
1986
48
Dracunculiasis in some Arkansas carnivores. (6238141)
1984
49
Metronidazole in dracunculiasis. A preliminary report. (4247716)
1970
50
Scrotal dracunculiasis. (4239003)
1969

Variations for Dracunculiasis

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Expression for genes affiliated with Dracunculiasis

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Expression patterns in normal tissues for genes affiliated with Dracunculiasis

Search GEO for disease gene expression data for Dracunculiasis.

Pathways for genes affiliated with Dracunculiasis

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Compounds for genes affiliated with Dracunculiasis

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GO Terms for genes affiliated with Dracunculiasis

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Products for genes affiliated with Dracunculiasis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Dracunculiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet