GWD
MCID: DRC001
MIFTS: 43

Dracunculiasis (GWD) malady

Infectious diseases category

Summaries for Dracunculiasis

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Sources:
8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. the female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. the worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards: Dracunculiasis, also known as guinea worm disease, is related to onchocerciasis and schistosomiasis, and has symptoms including restricted joint mobility/joint stiffness/ankylosis, severe allergic reaction/atopy and gangrena/necrosis. An important gene associated with Dracunculiasis is PRSS21 (protease, serine, 21 (testisin)). The drug thiabendazole has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast.

CDC:3 The program has made great strides from 3.5 million cases annually in the mid-1980s to 542 cases in 2012. In 2013, progress toward global Guinea worm disease eradication has accelerated. During January–June 2013, only 89 cases were reported worldwide, a 77% reduction in cases from the same period in 2012. Global eradication is within reach.

Wikipedia:63 Dracunculiasis, also called guinea worm disease (GWD), is an infection by the guinea worm. A person... more...

Aliases & Classifications for Dracunculiasis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
dracunculiasis:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

dracunculiasis 8 42 10 48 60
guinea worm disease 42 48
parasitic infection caused by dracunculus medinensis 42
infection by dracunculus medinensis 8
guinea worm infection 42
medina worm disease 48
dracunculosis 48
dracontiasis 8
medinensis 48
gwd 42


External Ids:

Disease Ontology8 DOID:14418
MeSH34 D004320
NCIt39 C84677
ICD9CM27 125.7
MESH via Orphanet35 D004320
SNOMED-CT56 48874008, 396334002
ICD10 via Orphanet26 B72
SNOMED-CT via Orphanet57 396334002
UMLS via Orphanet61 C0013100
ICD1025 B72

Related Diseases for Dracunculiasis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1onchocerciasis10.2
2schistosomiasis10.2
3trachoma10.1
4filariasis10.1
5smallpox10.1
6pleurisy10.0
7trichuriasis10.0
8tungiasis10.0
9yellow fever10.0
10typhoid fever10.0
11scurvy10.0
12malaria10.0
13loiasis10.0ONECUT3
14urethritis10.0
15ascariasis10.0
16breast disease10.0
17dermatitis10.0
18poliomyelitis10.0

Graphical network of diseases related to Dracunculiasis:



Diseases related to dracunculiasis

Clinical Features for Dracunculiasis

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Sources:
48Orphanet
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Symptoms:

48 (show all 15)
  • restricted joint mobility/joint stiffness/ankylosis
  • severe allergic reaction/atopy
  • gangrena/necrosis
  • contractures/cramps/trismus/tetania/claudication/opisthotonos
  • arthritis/synovitis/synovial proliferation
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • cutaneous rash
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • fever/chilling
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • chronic skin infection/ulcerations/ulcers/cancrum

Drugs & Therapeutics for Dracunculiasis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dracunculiasis

Drug clinical trials:

Search ClinicalTrials for Dracunculiasis

Search NIH Clinical Center for Dracunculiasis

Search CenterWatch for Dracunculiasis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Dracunculiasis

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Anatomical Context for Dracunculiasis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Dracunculiasis:

32
Skin, Bone, Breast, Testes, Spinal cord

Animal Models for Dracunculiasis or affiliated genes

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Publications for Dracunculiasis

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Sources:
50PubMed
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Articles related to Dracunculiasis:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Monthly report on dracunculiasis cases, Januarya89June 2013. (24040692)
2013
2
Monthly report on dracunculiasis cases, Januarya89April 2013. (23807971)
2013
3
Why is dracunculiasis eradication taking so long? (22520367)
2012
4
Dracunculiasis eradication a89 global surveillance summary, 2010. (21608202)
2011
5
Progress toward global eradication of dracunculiasis, January 2010-June 2011. (22031217)
2011
6
Emergence of Onchocerca volvulus from skin mimicking Dracunculiasis medinensis. (21118947)
2010
7
Monthly report on dracunculiasis cases, January-July 2009. (19764125)
2009
8
Progress toward global eradication of dracunculiasis, January 2008-June 2009. (19834453)
2009
9
Dracunculiasis eradication--global surveillance summary, 2008. (19425252)
2009
10
Monthly report on dracunculiasis cases, January-April 2009. (19480088)
2009
11
Update: progress toward global eradication of dracunculiasis, January 2007-June 2008. (18971919)
2008
12
Dracunculiasis eradication. Global surveillance summary, 2006. (17447325)
2007
13
Dracunculiasis eradication: ministerial meeting, Geneva, 16 May 2007. (17600955)
2007
14
Dracunculiasis eradication. Global surveillance summary, 2005. (16937766)
2006
15
Dracunculiasis eradication. (16676433)
2005
16
Dracunculiasis eradication status, 2004. (15739948)
2005
17
Dracunculiasis eradication. (15227956)
2004
18
Progress toward global eradication of dracunculiasis, January-June 2003. (13679790)
2003
19
Dracunculiasis eradication. Khartoum declaration on guinea-worm eradication, Sudan, 2002. (12078383)
2002
20
Dracunculiasis surveillance, Chad. (11957337)
2001
21
Dracunculiasis eradication: delayed, not denied. (10813467)
2000
22
Dracunculiasis. Global surveillance summary, 1997. (9594666)
1998
23
The acceptability and effectiveness of a polyester drinking-water filter in a dracunculiasis-endemic village in northern region, Ghana. (9447778)
1997
24
Dracunculiasis. Global surveillance summary, 1996. (9150687)
1997
25
Dracunculiasis. Progress towards global eradication. (8924384)
1996
26
An introduction to guinea worm on the eve of its departure: dracunculiasis transmission, health effects, ecology and control. (8913009)
1996
27
Update: dracunculiasis eradication--Ghana and Nigeria, 1994. (7870023)
1995
28
Dracunculiasis. Global surveillance summary, 1993. (8198959)
1994
29
Dracunculiasis in Burkina Faso: results of a national survey. (8254714)
1993
30
Update: dracunculiasis eradication--Ghana, 1992. (8429814)
1993
31
Dracunculiasis eradication. Update 1992. (8452783)
1993
32
A survey of human dracunculiasis in Kitgum District, Uganda. (7516676)
1993
33
Update: dracunculiasis eradication--Nigeria, 1992. (8474425)
1993
34
Update: dracunculiasis eradication--Ghana and Nigeria, 1991. (1534138)
1992
35
Dracunculiasis. (1531609)
1992
36
Epidemiology of dracunculiasis and its socio-economic impact in a village in south-west Nigeria. (1838698)
1991
37
Mebendazole treatment of dracunculiasis. (1832247)
1991
38
Dracunculiasis. (2145961)
1990
39
Dracunculiasis. (2145962)
1990
40
Update: dracunculiasis eradication--worldwide, 1989. (2136712)
1990
41
Dracunculiasis. (2143677)
1990
42
Surveillance: the foundation for control and elimination of dracunculiasis in Africa. (2533584)
1989
43
Dracunculiasis eradication: the tide has turned. (2899197)
1988
44
Pustular dermatitis caused by subcutaneous dracunculiasis in snakes. (2975646)
1986
45
Dracunculiasis in Igbon, Oyo State, Nigeria. (6240544)
1984
46
An outbreak of dracunculiasis in a peri-urban community of Ilorin, Kwara State, Nigeria. (6147987)
1984
47
Lessons learnt from the intensified campaign against smallpox in India and their possible applicability to other health programmes, with particular reference to eradication of dracunculiasis. (6458633)
1980
48
Efficacy of metronidazole in dracunculiasis. A clinical trial. (157076)
1979
49
Scrotal dracunculiasis. (4239003)
1969
50
Niridazole in dracunculiasis. (4235753)
1968

Genetic Variations for Dracunculiasis

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Expression for genes affiliated with Dracunculiasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dracunculiasis

Search GEO for disease gene expression data for Dracunculiasis.

Pathways for genes affiliated with Dracunculiasis

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Compounds for genes affiliated with Dracunculiasis

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GO Terms for genes affiliated with Dracunculiasis

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Products for genes affiliated with Dracunculiasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dracunculiasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet