MCID: DRC001
MIFTS: 45

Dracunculiasis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Dracunculiasis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 2CDC, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Dracunculiasis:

Name: Dracunculiasis 10 45 12 51 36 2 65
Guinea Worm Disease 45 51 2
Parasitic Infection Caused by Dracunculus Medinensis 45
Infection by Dracunculus Medinensis 10
Guinea Worm Infection 45
 
Medina Worm Disease 51
Dracunculosis 51
Dracontiasis 10
Medinensis 51
Gwd 45

Characteristics:

Orphanet epidemiological data:

51
dracunculiasis:
Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:14418
ICD1027 B72
ICD9CM29 125.7
MeSH36 D004320
NCIt42 C84677
SNOMED-CT59 396334002, 48874008
Orphanet51 231
ICD10 via Orphanet28 B72
MESH via Orphanet37 D004320
UMLS via Orphanet66 C0013100
UMLS65 C0013100

Summaries for Dracunculiasis

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Disease Ontology:10 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards based summary: Dracunculiasis, also known as guinea worm disease, is related to fryns syndrome and pancreatitis, and has symptoms including skin rash, pruritus and diarrhea. An important gene associated with Dracunculiasis is SETDB1 (SET Domain Bifurcated 1), and among its related pathways are Naphthalene metabolism and . The drug thiabendazole has been mentioned in the context of this disorder. Affiliated tissues include skin, bone and breast.

CDC:2 The program has made great strides from 3.5 million cases annually in the mid-1980s to 126 cases in 2014.  In 2015, only 22 cases were reported worldwide—a 83% reduction in cases from the previous year. Global eradication is within reach.

Wikipedia:68 Dracunculiasis, also called Guinea worm disease (GWD), is an infection by the Guinea worm. A person... more...

Related Diseases for Dracunculiasis

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Graphical network of the top 20 diseases related to Dracunculiasis:



Diseases related to dracunculiasis

Symptoms for Dracunculiasis

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Symptoms:

 51 (show all 15)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • cutaneous rash
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • pruritus/itching
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute diarrhea
  • fever/chilling
  • cellulitis/panniculitis/pseudocellulitis/inflammation of subcutaneous tissue
  • furuncle/cutaneous abscess/hidrosadenitis suppurativa
  • arthritis/synovitis/synovial proliferation
  • restricted joint mobility/joint stiffness/ankylosis
  • severe allergic reaction/atopy
  • gangrena/necrosis
  • contractures/cramps/trismus/tetania/claudication/opisthotonos

HPO human phenotypes related to Dracunculiasis:

(show all 14)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 pruritus hallmark (90%) HP:0000989
3 diarrhea hallmark (90%) HP:0002014
4 nausea and vomiting hallmark (90%) HP:0002017
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 abnormal blistering of the skin hallmark (90%) HP:0008066
7 skin ulcer hallmark (90%) HP:0200042
8 arthritis typical (50%) HP:0001369
9 limitation of joint mobility typical (50%) HP:0001376
10 immunologic hypersensitivity typical (50%) HP:0100326
11 cellulitis typical (50%) HP:0100658
12 recurrent cutaneous abscess formation typical (50%) HP:0100838
13 flexion contracture occasional (7.5%) HP:0001371
14 gangrene occasional (7.5%) HP:0100758

Drugs & Therapeutics for Dracunculiasis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Dracunculiasis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: dracunculiasis

Genetic Tests for Dracunculiasis

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Anatomical Context for Dracunculiasis

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MalaCards organs/tissues related to Dracunculiasis:

33
Skin, Bone, Breast, T cells, Prostate, Endothelial, Lung

Animal Models for Dracunculiasis or affiliated genes

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Publications for Dracunculiasis

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Articles related to Dracunculiasis:

(show top 50)    (show all 315)
idTitleAuthorsYear
1
Cytomegalovirus meningoencephalitis after rituximab treatment for primary central nervous system lymphoma. (25607329)
2015
2
Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma. (25479586)
2015
3
IL12p40 regulates functional development of human CD4+ T cells: enlightenment by the elevated expressions of IL12p40 in patients with inflammatory bowel diseases. (25761185)
2015
4
Post-traumatic humero-ulnar synostosis. (24732097)
2014
5
Shoulder technique: A modified sleeve technique devised for treating isolated coronary stenosis at side branch ostium. (24342408)
2014
6
Outcome of microdissection TESE compared with conventional TESE in non-obstructive azoospermia: a systematic review. (24193894)
2014
7
Mixed pituitary adenoma/craniopharyngioma: clinical, morphological, immunohistochemical and ultrastructural study of a case, review of the literature, and pathogenetic and nosological considerations. (23344977)
2014
8
Utility of serum IgG, IgG4 and carbonic anhydrase II antibodies in distinguishing autoimmune pancreatitis from pancreatic cancer and chronic pancreatitis. (25194335)
2014
9
Health-seeking behavior, alternative medicine, and quality of life in Taiwanese panic disorder patients. (22809126)
2013
10
The Preschool Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS) 6-year follow-up. (23452683)
2013
11
Depletion of Spleen Macrophages Delays AA Amyloid Development: A Study Performed in the Rapid Mouse Model of AA Amyloidosis. (24236094)
2013
12
PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. (22952809)
2012
13
Rituximab for patients with refractory mucous membrane pemphigoid. (21422323)
2011
14
Augmenting antidepressant medication with modular CBT for geriatric generalized anxiety disorder: a pilot study. (20872925)
2011
15
Structural analysis of an unusual bioactive N-acylated lipo-oligosaccharide LOS-IV in Mycobacterium marinum. (20964371)
2010
16
Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells. (20300530)
2010
17
A population-based study of ulnar neuropathy at the elbow in Washington State workers' compensation. (20568266)
2010
18
Reprogramming of Xist against the pluripotent state in fusion hybrids. (19843582)
2009
19
Case-control studies compare "apples and pears": Proposal for a retrospective cohort study in the USA of vaccination history in relation to subsequent childhood leukemia. (18774234)
2008
20
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (18799622)
2008
21
All-trans-retinoic acid as a possible cause of acute pancreatitis even in the absence of hypertriglyceridemia. (18566740)
2008
22
Theoretical model of human apolipoprotein B100 tertiary structure. (17109403)
2007
23
Kinetic modeling can describe in vivo glycolysis in Entamoeba histolytica. (17824961)
2007
24
BCL6 gene mutations in transitional cell carcinomas. (17542409)
2007
25
Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. (17559235)
2007
26
Expression of lumican, a small leucine-rich proteoglycan with antitumour activity, in human malignant melanoma. (17490399)
2007
27
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. (16885344)
2006
28
Minichromosome maintenance protein 7: a reliable tool for glioblastoma proliferation index. (16619508)
2006
29
Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndrome. (15991189)
2005
30
Outcome of acute ST-segment elevation myocardial infarction in diabetics treated with fibrinolytic or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: lessons from the GUSTO V trial. (14975461)
2004
31
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. (12887923)
2003
32
Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. (14602071)
2003
33
Stimulation of the mitogen-activated protein kinase pathway antagonizes TRAIL-induced apoptosis downstream of BID cleavage in human breast cancer MCF-7 cells. (12082620)
2002
34
Subjectively healthy elderly consuming a liquid nutrition supplement maintained body mass index and improved some nutritional parameters and perceived well-being. (10608948)
1999
35
Cytotoxicity of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine and 1-amino-4-phenylpyridinium ion, 1-amino analogues of MPTP and MPP+, to clonal pheochromocytoma PC12 cells. (9815183)
1998
36
Pituitary adenylyl cyclase-activating polypeptide and nerve growth factor use the proteasome to rescue nerve growth factor-deprived sympathetic neurons cultured from chick embryos. (9798912)
1998
37
A phytochrome from the fern Adiantum with features of the putative photoreceptor NPH1. (9861055)
1998
38
Identification and reconstruction of the binding site within alphaMbeta2 for a specific and high affinity ligand, NIF. (9211902)
1997
39
Folate-based thymidylate synthase inhibitors in cancer chemotherapy. (9147608)
1997
40
Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers. (9223060)
1997
41
Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization. (8954789)
1996
42
Thymic hyperplasia in adults following chemotherapy for malignancy. (7688954)
1993
43
3-Methylglutaconic aciduria in a patient with Pearson syndrome. (8482296)
1993
44
Rectal mucosal major basic protein in infants with dietary protein-induced colitis. (8328717)
1993
45
Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. (1596907)
1992
46
The ocular manifestations of multiple sclerosis. 1. Abnormalities of the afferent visual system. (1402963)
1992
47
Effect of intraoperative fluid administration and colloid osmotic pressure on the formation of intestinal edema during gastrointestinal surgery. (1702977)
1990
48
QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. (3818902)
1987
49
Ventriculitis in congenital rubella: ultrasound demonstration. (3306592)
1987
50
Maple syrup urine disease: emergency treatment of the neonate. (104150)
1978

Variations for Dracunculiasis

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Expression for genes affiliated with Dracunculiasis

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Search GEO for disease gene expression data for Dracunculiasis.

Pathways for genes affiliated with Dracunculiasis

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Pathways related to Dracunculiasis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9GSTA1, GSTA2
2
Show member pathways
9.9GSTA1, GSTA2
3
Show member pathways
8.7GSTA1, GSTA2, GSTA3, GSTA4
4
Show member pathways
8.2GSTA1, GSTA2, GSTA3, GSTA4, HPGDS
5
Show member pathways
8.2GSTA1, GSTA2, GSTA3, GSTA4, HPGDS
6
Show member pathways
8.2GSTA1, GSTA2, GSTA3, GSTA4, HPGDS

GO Terms for genes affiliated with Dracunculiasis

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Biological processes related to Dracunculiasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00068058.2GSTA1, GSTA2, GSTA3, GSTA4, HPGDS

Sources for Dracunculiasis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet