MCID: DRC001
MIFTS: 40

Dracunculiasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Dracunculiasis

MalaCards integrated aliases for Dracunculiasis:

Name: Dracunculiasis 12 72 49 55 3 41 14 69
Guinea Worm Disease 49 55 3
Parasitic Infection Caused by Dracunculus Medinensis 49
Infection by Dracunculus Medinensis 12
Guinea Worm Infection 49
Medina Worm Disease 55
Dracunculosis 55
Dracontiasis 12
Medinensis 55
Gwd 49

Characteristics:

Orphanet epidemiological data:

55
dracunculiasis
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14418
ICD10 32 B72
ICD9CM 34 125.7
MeSH 41 D004320
NCIt 46 C84677
SNOMED-CT 64 396334002 48874008
Orphanet 55 ORPHA231
MESH via Orphanet 42 D004320
UMLS via Orphanet 70 C0013100
ICD10 via Orphanet 33 B72
UMLS 69 C0013100

Summaries for Dracunculiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards based summary : Dracunculiasis, also known as guinea worm disease, is related to schistosoma mansoni infection, susceptibility/ and schistosomiasis, and has symptoms including skin rash, pruritus and arthritis. An important gene associated with Dracunculiasis is SETDB1 (SET Domain Bifurcated 1). Affiliated tissues include skin, bone and testes.

CDC : 3 The program has made great strides from 3.5 million cases annually in the mid-1980s to 25 cases in 2016. Global eradication is within reach.

Wikipedia : 72 Dracunculiasis, also called Guinea-worm disease (GWD), is an infection by the Guinea worm. A person... more...

Related Diseases for Dracunculiasis

Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 schistosoma mansoni infection, susceptibility/ 10.1
2 schistosomiasis 10.1
3 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
4 onchocerciasis 10.0
5 smallpox 10.0
6 pleurisy 9.9
7 trachoma 9.9
8 malaria 9.9
9 tungiasis 9.9
10 trichuriasis 9.9
11 typhoid fever 9.9
12 yellow fever 9.9
13 inappropriate adh syndrome 9.9 AVPR2 SNAI1
14 filariasis 9.8
15 filarial elephantiasis 9.8
16 ancylostomiasis 9.8
17 urethritis 9.8
18 dermatitis 9.8
19 poliomyelitis 9.8
20 muscular atrophy 9.8
21 parasitic helminthiasis infectious disease 9.8

Graphical network of the top 20 diseases related to Dracunculiasis:



Diseases related to Dracunculiasis

Symptoms & Phenotypes for Dracunculiasis

Human phenotypes related to Dracunculiasis:

55 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 skin rash 55 31 hallmark (90%) Very frequent (99-80%) HP:0000988
2 pruritus 55 31 hallmark (90%) Very frequent (99-80%) HP:0000989
3 arthritis 55 31 frequent (33%) Frequent (79-30%) HP:0001369
4 flexion contracture 55 31 occasional (7.5%) Occasional (29-5%) HP:0001371
5 limitation of joint mobility 55 31 frequent (33%) Frequent (79-30%) HP:0001376
6 subcutaneous nodule 55 31 hallmark (90%) Very frequent (99-80%) HP:0001482
7 diarrhea 55 31 hallmark (90%) Very frequent (99-80%) HP:0002014
8 nausea and vomiting 55 31 hallmark (90%) Very frequent (99-80%) HP:0002017
9 abnormal blistering of the skin 55 31 hallmark (90%) Very frequent (99-80%) HP:0008066
10 low-grade fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0011134
11 immunologic hypersensitivity 55 31 frequent (33%) Frequent (79-30%) HP:0100326
12 cellulitis 55 31 frequent (33%) Frequent (79-30%) HP:0100658
13 gangrene 55 31 occasional (7.5%) Occasional (29-5%) HP:0100758
14 recurrent cutaneous abscess formation 55 31 frequent (33%) Frequent (79-30%) HP:0100838
15 skin ulcer 55 31 hallmark (90%) Very frequent (99-80%) HP:0200042

Drugs & Therapeutics for Dracunculiasis

Search Clinical Trials , NIH Clinical Center for Dracunculiasis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: dracunculiasis

Genetic Tests for Dracunculiasis

Anatomical Context for Dracunculiasis

MalaCards organs/tissues related to Dracunculiasis:

38
Skin, Bone, Testes, Spinal Cord

Publications for Dracunculiasis

Articles related to Dracunculiasis:

(show top 50) (show all 324)
# Title Authors Year
1
Dracunculiasis eradication: global surveillance summary, 2016. ( 28530374 )
2017
2
The painting of St. Roch in the picture gallery of Bari (15th century): An ancient representation of dracunculiasis? ( 28189713 )
2017
3
Progress Toward Global Eradication of Dracunculiasis, January 2016-June 2017. ( 29216028 )
2017
4
Smallpox and Dracunculiasis: The Scientific Value of Infectious Diseases That Have Been Eradicated or Targeted for Eradication. Is Schistosomiasis Next? ( 26741130 )
2016
5
Dracunculiasis eradication: global surveillance summary, 2015. ( 27132287 )
2016
6
Dracunculiasis in oral and maxillofacial surgery. ( 27162746 )
2016
7
Progress Toward Global Eradication of Dracunculiasis -January 2015-June 2016. ( 27736840 )
2016
8
Monthly report on dracunculiasis cases, January-April 2015. ( 26027017 )
2015
9
Monthly report on dracunculiasis cases, January- September 2015. ( 26591027 )
2015
10
Monthly report on dracunculiasis cases, Januarya89 February 2015. ( 25958418 )
2015
11
Monthly report on dracunculiasis cases, January-May 2015. ( 26121769 )
2015
12
Monthly report on dracunculiasis cases, January-July 2015. ( 26454889 )
2015
13
Progress Toward Global Eradication of Dracunculiasis, January 2014-June 2015. ( 26492134 )
2015
14
Monthly report on dracunculiasis cases, January-June 2015. ( 26298884 )
2015
15
Dracunculiasis eradication: global surveillance summary, 2014. ( 25958417 )
2015
16
Monthly report on dracunculiasis cases, Januarya89November 2014. ( 25671847 )
2015
17
Monthly report on dracunculiasis cases, Januarya89December 2014. ( 25702332 )
2015
18
Monthly report on dracunculiasis cases, January-October 2015. ( 26685392 )
2015
19
An experience with dracunculiasis in Melbourne, Australia. ( 25393260 )
2014
20
Monthly report on dracunculiasis cases, Januarya89February 2014. ( 24707536 )
2014
21
The peculiar epidemiology of dracunculiasis in chad. ( 24277785 )
2014
22
Monthly report on dracunculiasis cases, Januarya89June 2014. ( 25136722 )
2014
23
Guinea worm (Dracunculiasis) eradication: update on progress and endgame challenges. ( 24699360 )
2014
24
Monthly report on dracunculiasis cases, January 2014. ( 24707516 )
2014
25
Monthly report on dracunculiasis cases, Januarya89July 2014. ( 25184187 )
2014
26
Monthly report on dracunculiasis cases, Januarya89October 2014. ( 25538996 )
2014
27
Monthly report on dracunculiasis cases, Januarya89May 2014. ( 25028755 )
2014
28
Monthly report on dracunculiasis cases, Januarya89November 2013. ( 24446560 )
2014
29
Monthly report on dracunculiasis cases, Januarya89December 2013. ( 24707512 )
2014
30
Dracunculiasis eradication--global surveillance summary, 2013. ( 24864343 )
2014
31
Progress toward global eradication of dracunculiasis--January 2013-June 2014. ( 25412061 )
2014
32
Monthly report on dracunculiasis cases, Januarya89August 2014. ( 25313424 )
2014
33
Monthly report on dracunculiasis cases, January a89- April 2014. ( 24864344 )
2014
34
Dracunculiasis eradication: and now, South Sudan. ( 23843492 )
2013
35
Dracunculiasis (guinea worm disease): eradication without a drug or a vaccine. ( 23798694 )
2013
36
Monthly report on dracunculiasis cases, January a89 August 2013. ( 24159669 )
2013
37
Monthly report on dracunculiasis cases, Januarya89June 2013. ( 24040692 )
2013
38
Monthly report on dracunculiasis cases, Januarya89December 2012. ( 23540052 )
2013
39
Monthly report on dracunculiasis cases, January a89- May 2013. ( 23980291 )
2013
40
Monthly report on dracunculiasis cases, Januarya89September 2013. ( 24319785 )
2013
41
Monthly report on dracunculiasis cases, Januarya89April 2013. ( 23807971 )
2013
42
Monthly report on dracunculiasis cases, January a89 February 2013. ( 23586140 )
2013
43
Monthly report on dracunculiasis cases, Januarya89November 2012. ( 23393705 )
2013
44
Monthly report on dracunculiasis cases, January a89 March 2013. ( 23696982 )
2013
45
Monthly report on dracunculiasis cases, Januarya89October 2013. ( 24436997 )
2013
46
Monthly report on dracunculiasis cases, January - July 2013. ( 24143843 )
2013
47
Dracunculiasis eradication a89 global surveillance summary, 2012. ( 23696981 )
2013
48
Progress toward global eradication of dracunculiasis--January 2012-June 2013. ( 24153313 )
2013
49
Monthly report on dracunculiasis cases, January 2013 a89 first month with zero cases. ( 23544240 )
2013
50
Monthly report on dracunculiasis cases, January-March 2012. ( 24340406 )
2012

Variations for Dracunculiasis

Expression for Dracunculiasis

Search GEO for disease gene expression data for Dracunculiasis.

Pathways for Dracunculiasis

GO Terms for Dracunculiasis

Biological processes related to Dracunculiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homotetramerization GO:0051289 8.62 HM13 SAMHD1

Sources for Dracunculiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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