MCID: DRG011
MIFTS: 48

Drug Addiction malady

Summaries for Drug Addiction

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Sources:
66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Substance dependence, commonly called drug addiction, is a compulsive need to use drugs in order to... more...

MalaCards: Drug Addiction, also known as drug dependence, is related to substance abuse and obesity. An important gene associated with Drug Addiction is FAAH (fatty acid amide hydrolase), and among its related pathways are GPCRs, Other and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and amygdala, and related mouse phenotypes are adipose tissue and growth/size/body.

Description from OMIM:48 606581

Aliases & Classifications for Drug Addiction

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Sources:
63UMLS, 48OMIM, 46Novoseek
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Aliases & Descriptions:

drug addiction 48 46
drug dependence 63


Related Diseases for Drug Addiction

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Drug Addiction:



Diseases related to drug addiction

Symptoms for Drug Addiction

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Sources:
48OMIM
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Clinical features from OMIM:

606581

Drugs & Therapeutics for Drug Addiction

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Drug Addiction

Drug clinical trials:

Search ClinicalTrials for Drug Addiction

Search NIH Clinical Center for Drug Addiction

Search CenterWatch for Drug Addiction

Genetic Tests for Drug Addiction

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Anatomical Context for Drug Addiction

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Sources:
34MalaCards
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MalaCards organs/tissues related to Drug Addiction:

34
Brain, Cortex, Amygdala, Lung, Testes, Prefrontal cortex, Hypothalamus, Pituitary

Animal Models for Drug Addiction or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Drug Addiction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9DRD1, DRD3, PDYN
2MP:00053787.6HCRT, PDYN, CRH, DRD3, DRD1
3MP:00107717.5FAAH, PDYN, CRH, DRD1, OPRD1
4MP:00053866.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
5MP:00036316.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
6MP:00053766.5OPRD1, DARC, HCRT, FAAH, PDYN, CRH

Publications for Drug Addiction

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Sources:
53PubMed
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Articles related to Drug Addiction:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Drug addiction in pregnancy: disease not moral failure. (24413031)
2014
2
Epigenetic mechanisms of drug addiction. (23374537)
2013
3
Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing To Drug Addiction: Effect of Ovarian Hormones. (23829370)
2013
4
Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. (22896771)
2012
5
Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers. (21169391)
2011
6
Wearable sensor platform and mobile application for use in cognitive behavioral therapy for drug addiction and PTSD. (22254678)
2011
7
What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? (20846139)
2011
8
Drug addiction, love, and the higher power. (21411471)
2011
9
Animal models of drug addiction in support of novel therapeutic strategies. (23382141)
2011
10
Advances in animal models of drug addiction. (21225413)
2011
11
Drug addiction finds its own niche. (22074974)
2011
12
Novel perspectives on drug addiction and reward. (20493904)
2010
13
The role of executive control in human drug addiction. (21161758)
2010
14
Epigenetic modifications: significance in drug addiction and treatment. (22121869)
2010
15
Pharmacologically-induced stress: a cross-species probe for translational research in drug addiction and relapse. (21139808)
2010
16
Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. (19307583)
2009
17
Computational approaches to the neurobiology of drug addiction. (19434552)
2009
18
Traditional medicine in the treatment of drug addiction. (19152199)
2009
19
Drug addiction as a brain disorder or disease. (19436014)
2009
20
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
21
Drug addiction as a pathology of staged neuroplasticity. (17805308)
2008
22
Sensitization, drug addiction and psychopathology in animals and humans. (17900776)
2007
23
Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis. (16911735)
2006
24
Salt addiction: a different kind of drug addiction. (16790320)
2006
25
Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese? (16759334)
2006
26
Involvement of the endocannabinoid system in drug addiction. (16483675)
2006
27
Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. (15661634)
2005
28
Synaptic plasticity and drug addiction. (15661621)
2005
29
Novel pharmacotherapeutic targets for the management of drug addiction. (16253234)
2005
30
Neurotrophic mechanisms in drug addiction. (15001814)
2004
31
Detection methods of the drug-addiction and alcoholism treatment programme of the Spanish National Railway Company (RENFE). (14526495)
2003
32
Parental rearing and individual vulnerability to drug addiction: a controlled study in a Swedish sample. (12745778)
2003
33
U.S. Supreme Court to review drug addiction case. (14593342)
2003
34
Lack of association between parental alcohol or drug addiction and behavioral inhibition in children. (11579013)
2001
35
The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction. (11240309)
2001
36
I have HIV. My #1 disease is drug addiction. (11682999)
2001
37
Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function? (11268408)
2000
38
Report on drug addiction. Reprinted from the Bulletin on the New York Academy of Medicine 1995; 31(8): 592-607. The New York Academy of Medicine Committee on Public Health Subcommittee on Drug Addiction. 1995. (10976618)
2000
39
Drug addiction. (11533766)
2000
40
Safe approaches to treating drug addiction. (10962832)
2000
41
The problem of drug addiction among secondary school students in Lublin. Young people's knowledge about the effects of taking drugs. (11482080)
2000
42
Development of novel medications for drug addiction. The legacy of an African shrub. (10911925)
2000
43
Drug addiction therapy. A dance to the music of time. (10662323)
1999
44
Stress, corticotropin-releasing factor, and drug addiction. (10676433)
1999
45
Learning and homeostasis: drug addiction and the McCollough effect. (9747187)
1998
46
Genetic analysis of drug addiction: the role of cAMP response element binding protein. (9500675)
1998
47
Biochemical response to interferon of chronic hepatitis in drug-addict patients infected with human immunodeficiency virus. (12847309)
1997
48
Telling the patient the diagnosis of alcoholism or drug addiction: an internist's perspective. (7596240)
1995
49
Drug delivery systems: possible applications in the treatment of drug addiction. (8775840)
1995
50
Nutritional status assessment of HIV-positive drug addicts. (2387276)
1990

Variations for Drug Addiction

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Expression for genes affiliated with Drug Addiction

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Drug Addiction

Search GEO for disease gene expression data for Drug Addiction.

Pathways for genes affiliated with Drug Addiction

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Sources:
51PathCards, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 56Reactome, 13EMD Millipore
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Pathways related to Drug Addiction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DRD3, DARC
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons39
9.5DRD3, DRD1
3
Show member pathways
9.5DRD1, DRD3
4
Show member pathways
9.3DRD1, PDYN
59.3CRH, PDYN
6
Show member pathways
9.2DRD1, DRD3, FAAH
7
Show member pathways
Peptide GPCRs39
8.8DARC, HCRT, OPRD1
8
Show member pathways
8.8DRD1, CRH, PDYN
9
Show member pathways
6.7DARC, HCRT, PDYN, CRH, DRD3, DRD1
10
Show member pathways
6.7OPRD1, DARC, HCRT, PDYN, CRH, DRD3

Compounds for genes affiliated with Drug Addiction

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Sources:
30IUPHAR, 46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
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Compounds related to Drug Addiction according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cis flupentixol309.8DRD3, DRD1
2eticlopride46 3010.8DRD1, DRD3
3aripiprazole30 46 52 25 1213.6FAAH, DRD3, DRD1
4quetiapine46 52 30 25 1213.6DRD1, DRD3, FAAH
5risperidone46 52 30 62 25 1214.6DRD1, FAAH, DRD3
6sch 23390469.5DRD3, DRD1
7olanzapine46 52 30 25 1213.5FAAH, DRD3, DRD1
8quinpirole46 3010.3DRD3, PDYN, DRD1
96-hydroxydopamine469.3DRD1, PDYN, DRD3
10(+)-butaclamol46 3010.2DRD1, DRD3
11dermorphin469.2PDYN, OPRD1
12nalmefene46 3010.2PDYN, OPRD1
13amphetamine46 52 1211.2DRD1, HCRT, PDYN
14haloperidol46 52 30 3 1213.1DRD1, HCRT, FAAH, DRD3
15pentazocine46 1210.1PDYN, OPRD1
16atropine46 30 1211.1PDYN, DRD1, CRH
17norbinaltorphimine469.1PDYN, OPRD1
18heroin46 52 1211.0DRD3, PDYN, OPRD1
19npff469.0OPRD1, PDYN, HCRT
20tetrodotoxin46 62 3010.9CRH, HCRT, OPRD1
21levodopa46 129.9DRD3, DRD1, PDYN
22sulpiride46 30 1210.8DRD3, CRH, DRD1, PDYN
23capsaicin46 309.8CRH, PDYN, OPRD1
24clozapine46 30 52 1211.8FAAH, DRD1, OPRD1, DRD3
25carbachol46 30 1210.6HCRT, OPRD1, CRH, DRD1
26naloxone46 30 52 1211.4DRD1, OPRD1, PDYN, CRH
27acth468.4PDYN, CRH, OPRD1, HCRT
28epinephrine46 25 1210.4OPRD1, HCRT, PDYN, CRH
29potassium46 25 1210.4OPRD1, HCRT, PDYN, DRD3
30catecholamine468.4HCRT, PDYN, CRH, DRD3, DRD1
31alanine468.3HCRT, OPRD1, CRH, FAAH, DARC
32gtp46 309.2DRD3, DRD1, OPRD1, PDYN
33estrogen468.2HCRT, FAAH, PDYN, CRH, DRD1
34methamphetamine46 52 1210.2DRD3, PDYN, FAAH, DRD1, OPRD1
35cyclic amp46 259.1OPRD1, DRD1, DRD3, CRH, HCRT
36nmda46 309.1HCRT, PDYN, DRD3, DRD1, OPRD1
37nitric oxide46 25 1210.1PDYN, DRD1, OPRD1, FAAH, HCRT
38gnrh468.0HCRT, OPRD1, DRD1, CRH, PDYN
39gaba468.0HCRT, PDYN, CRH, OPRD1, DRD1
40acetylcholine46 52 30 25 1212.0HCRT, PDYN, CRH, DRD1, OPRD1
41adenylate467.9HCRT, OPRD1, DRD1, CRH, PDYN
42lipid467.7FAAH, PDYN, HCRT, DARC, OPRD1, DRD1
43opiate467.6CRH, PDYN, DRD3, HCRT, DRD1, OPRD1
44cocaine46 128.6HCRT, OPRD1, DRD1, DRD3, PDYN, CRH
45nicotine46 30 52 1210.6DRD1, HCRT, PDYN, CRH, OPRD1, DRD3
46norepinephrine46 25 129.6CRH, DRD3, DRD1, OPRD1, PDYN, HCRT
47dopamine46 30 25 1210.6PDYN, CRH, DRD3, DRD1, OPRD1, HCRT
48glutamate467.5OPRD1, DRD1, DRD3, PDYN, CRH, HCRT
49tyrosine467.3PDYN, OPRD1, DRD1, DARC, DRD3, FAAH
50calcium46 52 25 1210.2OPRD1, FAAH, HCRT, DRD3, PDYN, DRD1

GO Terms for genes affiliated with Drug Addiction

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17Gene Ontology
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Cellular components related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7OPRD1, DRD1, DRD3, PDYN, DARC

Biological processes related to Drug Addiction according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine uptake involved in synaptic transmissionGO:0515849.9DRD1, DRD3
2dopamine metabolic processGO:0424179.8DRD3, DRD1
3adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.8DRD3, DRD1
4behavioral response to cocaineGO:0481489.8DRD1, DRD3
5prepulse inhibitionGO:0601349.8DRD3, DRD1
6negative regulation of blood pressureGO:0457769.8DRD3, CRH
7response to amphetamineGO:0019759.7DRD3, DRD1
8long-term synaptic potentiationGO:0602919.7DRD1, CRH
9learning or memoryGO:0076119.7DRD3, CRH
10positive regulation of cAMP biosynthetic processGO:0308199.6DRD1, CRH
11response to ethanolGO:0454719.5DRD3, CRH
12visual learningGO:0085429.4DRD1, DRD3
13synaptic transmission, dopaminergicGO:0019639.3DRD1, DRD3, CRH
14phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.3HCRT, OPRD1
15response to drugGO:0424939.2DRD1, DRD3, CRH
16G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.1OPRD1, DRD1
17neuropeptide signaling pathwayGO:0072188.9HCRT, PDYN, OPRD1
18synaptic transmissionGO:0072688.6HCRT, PDYN, CRH

Molecular functions related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.5DRD1, DRD3

Products for genes affiliated with Drug Addiction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Drug Addiction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet