MCID: DRG011
MIFTS: 45

Drug Addiction malady

Genetic diseases (common) category

Aliases & Classifications for Drug Addiction

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Sources:
45OMIM, 43Novoseek, 60UMLS, 10diseasecard
See all sources

Drug Addiction, Aliases & Descriptions:

Name: Drug Addiction 45 43
Polysubstance Abuse 45 43 60
Drug Addiction, Susceptibility to 10
 
Substance Dependence 60
Drug Dependence 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM45 606581

Summaries for Drug Addiction

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MalaCards based summary: Drug Addiction, also known as polysubstance abuse, is related to substance abuse and pathological gambling. An important gene associated with Drug Addiction is FAAH (fatty acid amide hydrolase), and among its related pathways are GPCRs, Other and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and amygdala, and related mouse phenotypes are adipose tissue and growth/size/body.

Description from OMIM:45 606581

Related Diseases for Drug Addiction

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Diseases related to Drug Addiction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1substance abuse30.8CRH, DRD3
2pathological gambling30.7DRD1, DRD3
3substance dependence30.5PDYN, DRD3
4cocaine dependence30.3PDYN, DRD3
5obesity30.3FAAH, HCRT, CRH
6eating disorder30.2HCRT, CRH
7obsessive-compulsive disorder30.0PDYN, DRD3, DRD1
8alcohol dependence29.8OPRD1, CRH, DRD1
9drug dependence29.6PDYN, OPRD1, DRD3, DARC
10schizophrenia29.5PDYN, HCRT, FAAH, DRD3, DRD1
11hepatitis10.6
12neuronitis10.5
13hepatitis c10.5
14cannabis dependence10.4FAAH
15cerebritis10.3
16endocarditis10.3
17mononeuritis multiplex10.2
18mononeuritis10.2
19miliary tuberculosis10.2
20hepatitis d10.2
21melanoma10.2
22osteomyelitis10.2
23tuberculosis10.2
24viral hepatitis10.2
25major depressive disorder and accelerated response to antidepressant drug treatment10.2CRH, DRD3
26parkinson disease, late-onset10.2PDYN, DRD3
27gilles de la tourette syndrome10.2DRD1, DRD3
28withdrawal disorder10.1PDYN, CRH
29narcolepsy10.1HCRT, DRD1
30hepatitis c virus10.1
31myocardial infarction10.1
32malaria10.1
33peliosis hepatis10.1
34pemphigus10.1
35splenic abscess10.1
36plasmodium vivax malaria10.1
37anterior spinal artery syndrome10.1
38carotid artery dissection10.1
39amphetamine abuse10.1
40ecthyma10.1
41cocaine abuse10.1
42panophthalmitis10.1
43penicilliosis10.1
44kwashiorkor10.1
45wound botulism10.1
46arachnoiditis10.1
47necrotizing ulcerative gingivitis10.1
48alcohol-related neurodevelopmental disorder10.1
49fetal alcohol syndrome10.1
50anxiety disorder10.1

Graphical network of the top 20 diseases related to Drug Addiction:



Diseases related to drug addiction

Symptoms for Drug Addiction

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Clinical features from OMIM:

606581

Drugs & Therapeutics for Drug Addiction

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Drug clinical trials:

Search ClinicalTrials for Drug Addiction

Search NIH Clinical Center for Drug Addiction

Genetic Tests for Drug Addiction

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Anatomical Context for Drug Addiction

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MalaCards organs/tissues related to Drug Addiction:

31
Brain, Cortex, Amygdala, Lung, Testes, Prefrontal cortex, Hypothalamus, Pituitary

Animal Models for Drug Addiction or affiliated genes

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MGI Mouse Phenotypes related to Drug Addiction:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9DRD1, DRD3, PDYN
2MP:00053787.6HCRT, PDYN, CRH, DRD3, DRD1
3MP:00107717.5FAAH, PDYN, CRH, DRD1, OPRD1
4MP:00053866.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
5MP:00036316.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
6MP:00053766.5OPRD1, DARC, HCRT, FAAH, PDYN, CRH

Publications for Drug Addiction

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Articles related to Drug Addiction:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. (25823631)
2015
2
The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction. (25838241)
2015
3
Individual differences and vulnerability to drug addiction: a focus on the endocannabinoid system. (25714966)
2015
4
A new proposal for drug conditioning with implications for drug addiction: The Pavlovian two-step from delay to trace conditioning. (25218870)
2014
5
Non-human primate models in drug addiction deserve more attention. (24866486)
2014
6
Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention. (25657617)
2014
7
Stigma, discrimination, treatment effectiveness, and policy: public views about drug addiction and mental illness. (25270497)
2014
8
Drug addiction in pregnancy: disease not moral failure. (24413031)
2014
9
Paying attention to biased attention in drug addiction. (24901505)
2014
10
Epigenetic mechanisms of drug addiction. (23374537)
2013
11
Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing To Drug Addiction: Effect of Ovarian Hormones. (23829370)
2013
12
Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. (22896771)
2012
13
Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers. (21169391)
2011
14
Wearable sensor platform and mobile application for use in cognitive behavioral therapy for drug addiction and PTSD. (22254678)
2011
15
What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? (20846139)
2011
16
Drug addiction, love, and the higher power. (21411471)
2011
17
Animal models of drug addiction in support of novel therapeutic strategies. (23382141)
2011
18
Advances in animal models of drug addiction. (21225413)
2011
19
Novel perspectives on drug addiction and reward. (20493904)
2010
20
The role of executive control in human drug addiction. (21161758)
2010
21
Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. (19307583)
2009
22
Computational approaches to the neurobiology of drug addiction. (19434552)
2009
23
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
24
Drug addiction as a pathology of staged neuroplasticity. (17805308)
2008
25
Sensitization, drug addiction and psychopathology in animals and humans. (17900776)
2007
26
Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis. (16911735)
2006
27
Salt addiction: a different kind of drug addiction. (16790320)
2006
28
Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese? (16759334)
2006
29
Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. (15661634)
2005
30
Synaptic plasticity and drug addiction. (15661621)
2005
31
Novel pharmacotherapeutic targets for the management of drug addiction. (16253234)
2005
32
Neurotrophic mechanisms in drug addiction. (15001814)
2004
33
Detection methods of the drug-addiction and alcoholism treatment programme of the Spanish National Railway Company (RENFE). (14526495)
2003
34
Drug addiction and HIV infection on rise in Tajikistan. (14570036)
2003
35
Parental rearing and individual vulnerability to drug addiction: a controlled study in a Swedish sample. (12745778)
2003
36
Lack of association between parental alcohol or drug addiction and behavioral inhibition in children. (11579013)
2001
37
The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction. (11240309)
2001
38
I have HIV. My #1 disease is drug addiction. (11682999)
2001
39
Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function? (11268408)
2000
40
Report on drug addiction. Reprinted from the Bulletin on the New York Academy of Medicine 1995; 31(8): 592-607. The New York Academy of Medicine Committee on Public Health Subcommittee on Drug Addiction. 1995. (10976618)
2000
41
Drug addiction. (11533766)
2000
42
Safe approaches to treating drug addiction. (10962832)
2000
43
The problem of drug addiction among secondary school students in Lublin. Young people's knowledge about the effects of taking drugs. (11482080)
2000
44
Development of novel medications for drug addiction. The legacy of an African shrub. (10911925)
2000
45
Drug addiction therapy. A dance to the music of time. (10662323)
1999
46
Learning and homeostasis: drug addiction and the McCollough effect. (9747187)
1998
47
Genetic analysis of drug addiction: the role of cAMP response element binding protein. (9500675)
1998
48
Telling the patient the diagnosis of alcoholism or drug addiction: an internist's perspective. (7596240)
1995
49
Drug delivery systems: possible applications in the treatment of drug addiction. (8775840)
1995
50
Nutritional status assessment of HIV-positive drug addicts. (2387276)
1990

Variations for Drug Addiction

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Expression for genes affiliated with Drug Addiction

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Search GEO for disease gene expression data for Drug Addiction.

Pathways for genes affiliated with Drug Addiction

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Pathways related to Drug Addiction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DARC, DRD3
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
9.5DRD1, DRD3
3
Show member pathways
9.5DRD3, DRD1
4
Show member pathways
9.3DRD1, PDYN
5
Show member pathways
9.2FAAH, DRD3, DRD1
6
Show member pathways
8.8PDYN, CRH, DRD1
7
Show member pathways
6.7DARC, HCRT, PDYN, CRH, OPRD1, DRD1
8
Show member pathways
6.7DRD1, OPRD1, DRD3, CRH, PDYN, HCRT

Compounds for genes affiliated with Drug Addiction

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Compounds related to Drug Addiction according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cis flupentixol289.8DRD3, DRD1
2eticlopride43 2810.8DRD1, DRD3
3aripiprazole28 43 49 24 1213.6FAAH, DRD3, DRD1
4quetiapine43 49 28 24 1213.6DRD1, DRD3, FAAH
5risperidone43 49 28 59 24 1214.6DRD1, FAAH, DRD3
6sch 23390439.5DRD3, DRD1
7olanzapine43 49 28 24 1213.5FAAH, DRD3, DRD1
8quinpirole43 2810.3DRD3, PDYN, DRD1
96-hydroxydopamine439.3DRD1, PDYN, DRD3
10dermorphin439.2PDYN, OPRD1
11nalmefene43 2810.2PDYN, OPRD1
12amphetamine43 49 1211.2DRD1, HCRT, PDYN
13haloperidol43 49 28 2 1213.1DRD1, HCRT, FAAH, DRD3
14pentazocine43 1210.1OPRD1, PDYN
15atropine43 28 1211.1PDYN, DRD1, CRH
16norbinaltorphimine439.1PDYN, OPRD1
17heroin43 49 1211.0DRD3, PDYN, OPRD1
18npff439.0OPRD1, PDYN, HCRT
19tetrodotoxin43 59 2810.9CRH, HCRT, OPRD1
20levodopa43 129.9DRD1, PDYN, DRD3
21sulpiride43 28 1210.8DRD3, CRH, DRD1, PDYN
22capsaicin43 289.8CRH, PDYN, OPRD1
23clozapine43 28 49 1211.8FAAH, DRD1, OPRD1, DRD3
24[3h]diprenorphine438.7PDYN, OPRD1
25carbachol43 28 1210.6HCRT, OPRD1, CRH, DRD1
26naloxone43 28 49 1211.4DRD1, OPRD1, PDYN, CRH
27acth438.4PDYN, CRH, OPRD1, HCRT
28epinephrine43 24 1210.4OPRD1, HCRT, PDYN, CRH
29potassium43 24 1210.4OPRD1, HCRT, PDYN, DRD3
30catecholamine438.4HCRT, PDYN, CRH, DRD3, DRD1
31alanine438.3HCRT, OPRD1, CRH, FAAH, DARC
32gtp43 289.2DRD3, OPRD1, PDYN, DRD1
33estrogen438.2HCRT, FAAH, PDYN, CRH, DRD1
34methamphetamine43 49 1210.2DRD3, PDYN, FAAH, DRD1, OPRD1
35cyclic amp43 249.1OPRD1, DRD1, DRD3, CRH, HCRT
36nmda43 289.1HCRT, PDYN, DRD3, DRD1, OPRD1
37nitric oxide43 24 1210.1PDYN, DRD1, OPRD1, FAAH, HCRT
38gnrh438.0HCRT, OPRD1, DRD1, CRH, PDYN
39gaba438.0HCRT, PDYN, CRH, OPRD1, DRD1
40acetylcholine43 49 28 24 1212.0HCRT, PDYN, CRH, DRD1, OPRD1
41adenylate437.9HCRT, OPRD1, DRD1, CRH, PDYN
42lipid437.7FAAH, PDYN, HCRT, DARC, OPRD1, DRD1
43opiate437.6CRH, PDYN, DRD3, HCRT, DRD1, OPRD1
44cocaine43 128.6HCRT, OPRD1, DRD1, DRD3, PDYN, CRH
45nicotine43 28 49 1210.6DRD1, HCRT, PDYN, CRH, OPRD1, DRD3
46norepinephrine43 24 129.6CRH, DRD3, DRD1, OPRD1, PDYN, HCRT
47dopamine43 28 24 1210.6PDYN, CRH, DRD3, DRD1, OPRD1, HCRT
48glutamate437.5OPRD1, DRD1, DRD3, PDYN, CRH, HCRT
49tyrosine437.3PDYN, OPRD1, DRD1, DARC, DRD3, FAAH
50calcium43 49 24 1210.2OPRD1, FAAH, HCRT, DRD3, PDYN, DRD1

GO Terms for genes affiliated with Drug Addiction

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Cellular components related to Drug Addiction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.7OPRD1, DRD1, DRD3, PDYN, DARC

Biological processes related to Drug Addiction according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine uptake involved in synaptic transmissionGO:00515849.9DRD1, DRD3
2dopamine metabolic processGO:00424179.8DRD3, DRD1
3adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.8DRD3, DRD1
4behavioral response to cocaineGO:00481489.8DRD1, DRD3
5prepulse inhibitionGO:00601349.8DRD3, DRD1
6negative regulation of blood pressureGO:00457769.8DRD3, CRH
7response to amphetamineGO:00019759.7DRD3, DRD1
8long-term synaptic potentiationGO:00602919.7DRD1, CRH
9learning or memoryGO:00076119.7DRD3, CRH
10positive regulation of cAMP biosynthetic processGO:00308199.6DRD1, CRH
11response to ethanolGO:00454719.5DRD3, CRH
12visual learningGO:00085429.4DRD1, DRD3
13synaptic transmission, dopaminergicGO:00019639.3DRD1, DRD3, CRH
14phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.3HCRT, OPRD1
15response to drugGO:00424939.2DRD1, DRD3, CRH
16G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.1OPRD1, DRD1
17neuropeptide signaling pathwayGO:00072188.9HCRT, PDYN, OPRD1
18synaptic transmissionGO:00072688.6HCRT, PDYN, CRH

Molecular functions related to Drug Addiction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:00352409.5DRD1, DRD3

Products for genes affiliated with Drug Addiction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Drug Addiction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet