MCID: DRG011
MIFTS: 48

Drug Addiction malady

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Summaries for Drug Addiction

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Substance dependence, commonly called drug addiction, is a compulsive need to use drugs in order to... more...

MalaCards: Drug Addiction, also known as drug dependence, is related to substance abuse and obesity. An important gene associated with Drug Addiction is FAAH (fatty acid amide hydrolase), and among its related pathways are GPCRs, Other and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and amygdala, and related mouse phenotypes are adipose tissue and growth/size/body.

Description from OMIM:47 606581

Aliases & Classifications for Drug Addiction

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62UMLS, 47OMIM, 45Novoseek
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Aliases & Descriptions:

drug addiction 47 45
drug dependence 62


Related Diseases for Drug Addiction

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Drug Addiction:



Diseases related to drug addiction

Symptoms for Drug Addiction

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47OMIM
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Clinical features from OMIM:

606581

Drugs & Therapeutics for Drug Addiction

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Drug Addiction

Search NIH Clinical Center for Drug Addiction

Genetic Tests for Drug Addiction

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Anatomical Context for Drug Addiction

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33MalaCards
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MalaCards organs/tissues related to Drug Addiction:

33
Brain, Cortex, Amygdala, Lung, Testes, Prefrontal cortex, Hypothalamus, Pituitary

Animal Models for Drug Addiction or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Drug Addiction:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9DRD1, DRD3, PDYN
2MP:00053787.6HCRT, PDYN, CRH, DRD3, DRD1
3MP:00107717.5FAAH, PDYN, CRH, DRD1, OPRD1
4MP:00053866.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
5MP:00036316.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
6MP:00053766.5OPRD1, DARC, HCRT, FAAH, PDYN, CRH

Publications for Drug Addiction

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Sources:
52PubMed
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Articles related to Drug Addiction:

(show top 50)    (show all 516)
idTitleAuthorsYear
1
Drug addiction in pregnancy: disease not moral failure. (24413031)
2014
2
Epigenetic mechanisms of drug addiction. (23374537)
2013
3
Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing To Drug Addiction: Effect of Ovarian Hormones. (23829370)
2013
4
Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. (22896771)
2012
5
Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers. (21169391)
2011
6
Wearable sensor platform and mobile application for use in cognitive behavioral therapy for drug addiction and PTSD. (22254678)
2011
7
What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? (20846139)
2011
8
Drug addiction, love, and the higher power. (21411471)
2011
9
Animal models of drug addiction in support of novel therapeutic strategies. (23382141)
2011
10
Advances in animal models of drug addiction. (21225413)
2011
11
Drug addiction finds its own niche. (22074974)
2011
12
Novel perspectives on drug addiction and reward. (20493904)
2010
13
The role of executive control in human drug addiction. (21161758)
2010
14
Epigenetic modifications: significance in drug addiction and treatment. (22121869)
2010
15
Pharmacologically-induced stress: a cross-species probe for translational research in drug addiction and relapse. (21139808)
2010
16
Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. (19307583)
2009
17
Computational approaches to the neurobiology of drug addiction. (19434552)
2009
18
Traditional medicine in the treatment of drug addiction. (19152199)
2009
19
Drug addiction as a brain disorder or disease. (19436014)
2009
20
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
21
Drug addiction as a pathology of staged neuroplasticity. (17805308)
2008
22
Sensitization, drug addiction and psychopathology in animals and humans. (17900776)
2007
23
Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis. (16911735)
2006
24
Salt addiction: a different kind of drug addiction. (16790320)
2006
25
Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese? (16759334)
2006
26
Involvement of the endocannabinoid system in drug addiction. (16483675)
2006
27
Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. (15661634)
2005
28
Synaptic plasticity and drug addiction. (15661621)
2005
29
Novel pharmacotherapeutic targets for the management of drug addiction. (16253234)
2005
30
Neurotrophic mechanisms in drug addiction. (15001814)
2004
31
Detection methods of the drug-addiction and alcoholism treatment programme of the Spanish National Railway Company (RENFE). (14526495)
2003
32
Parental rearing and individual vulnerability to drug addiction: a controlled study in a Swedish sample. (12745778)
2003
33
U.S. Supreme Court to review drug addiction case. (14593342)
2003
34
Lack of association between parental alcohol or drug addiction and behavioral inhibition in children. (11579013)
2001
35
The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction. (11240309)
2001
36
I have HIV. My #1 disease is drug addiction. (11682999)
2001
37
Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function? (11268408)
2000
38
Report on drug addiction. Reprinted from the Bulletin on the New York Academy of Medicine 1995; 31(8): 592-607. The New York Academy of Medicine Committee on Public Health Subcommittee on Drug Addiction. 1995. (10976618)
2000
39
Drug addiction. (11533766)
2000
40
Safe approaches to treating drug addiction. (10962832)
2000
41
The problem of drug addiction among secondary school students in Lublin. Young people's knowledge about the effects of taking drugs. (11482080)
2000
42
Development of novel medications for drug addiction. The legacy of an African shrub. (10911925)
2000
43
Drug addiction therapy. A dance to the music of time. (10662323)
1999
44
Stress, corticotropin-releasing factor, and drug addiction. (10676433)
1999
45
Learning and homeostasis: drug addiction and the McCollough effect. (9747187)
1998
46
Genetic analysis of drug addiction: the role of cAMP response element binding protein. (9500675)
1998
47
Biochemical response to interferon of chronic hepatitis in drug-addict patients infected with human immunodeficiency virus. (12847309)
1997
48
Telling the patient the diagnosis of alcoholism or drug addiction: an internist's perspective. (7596240)
1995
49
Drug delivery systems: possible applications in the treatment of drug addiction. (8775840)
1995
50
Nutritional status assessment of HIV-positive drug addicts. (2387276)
1990

Variations for Drug Addiction

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Expression for genes affiliated with Drug Addiction

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Drug Addiction

Search GEO for disease gene expression data for Drug Addiction.

Pathways for genes affiliated with Drug Addiction

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 30KEGG, 55Reactome, 12EMD Millipore
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Pathways related to Drug Addiction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DRD3, DARC
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
9.5DRD3, DRD1
3
Show member pathways
9.5DRD1, DRD3
4
Show member pathways
9.3DRD1, PDYN
59.3CRH, PDYN
6
Show member pathways
9.2DRD1, DRD3, FAAH
7
Show member pathways
Peptide GPCRs38
8.8DARC, HCRT, OPRD1
8
Show member pathways
8.8DRD1, CRH, PDYN
9
Show member pathways
6.7DARC, HCRT, PDYN, CRH, DRD3, DRD1
10
Show member pathways
6.7OPRD1, DARC, HCRT, PDYN, CRH, DRD3

Compounds for genes affiliated with Drug Addiction

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Sources:
29IUPHAR, 45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank, 61Tocris Bioscience, 3BitterDB
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Compounds related to Drug Addiction according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cis flupentixol299.8DRD3, DRD1
2eticlopride45 2910.8DRD1, DRD3
3aripiprazole29 45 51 24 1113.6FAAH, DRD3, DRD1
4quetiapine45 51 29 24 1113.6DRD1, DRD3, FAAH
5risperidone45 51 29 61 24 1114.6DRD1, FAAH, DRD3
6sch 23390459.5DRD3, DRD1
7olanzapine45 51 29 24 1113.5FAAH, DRD3, DRD1
8quinpirole45 2910.3DRD3, PDYN, DRD1
96-hydroxydopamine459.3DRD1, PDYN, DRD3
10(+)-butaclamol45 2910.2DRD1, DRD3
11dermorphin459.2PDYN, OPRD1
12nalmefene45 2910.2PDYN, OPRD1
13amphetamine45 51 1111.2DRD1, HCRT, PDYN
14haloperidol45 51 29 3 1113.1DRD1, HCRT, FAAH, DRD3
15pentazocine45 1110.1PDYN, OPRD1
16atropine45 29 1111.1PDYN, DRD1, CRH
17norbinaltorphimine459.1PDYN, OPRD1
18heroin45 51 1111.0DRD3, PDYN, OPRD1
19npff459.0OPRD1, PDYN, HCRT
20tetrodotoxin45 61 2910.9CRH, HCRT, OPRD1
21levodopa45 119.9DRD3, DRD1, PDYN
22sulpiride45 29 1110.8DRD3, CRH, DRD1, PDYN
23capsaicin45 299.8CRH, PDYN, OPRD1
24clozapine45 29 51 1111.8FAAH, DRD1, OPRD1, DRD3
25carbachol45 29 1110.6HCRT, OPRD1, CRH, DRD1
26naloxone45 29 51 1111.4DRD1, OPRD1, PDYN, CRH
27acth458.4PDYN, CRH, OPRD1, HCRT
28epinephrine45 24 1110.4OPRD1, HCRT, PDYN, CRH
29potassium45 24 1110.4OPRD1, HCRT, PDYN, DRD3
30catecholamine458.4HCRT, PDYN, CRH, DRD3, DRD1
31alanine458.3HCRT, OPRD1, CRH, FAAH, DARC
32gtp45 299.2DRD3, DRD1, OPRD1, PDYN
33estrogen458.2HCRT, FAAH, PDYN, CRH, DRD1
34methamphetamine45 51 1110.2DRD3, PDYN, FAAH, DRD1, OPRD1
35cyclic amp45 249.1OPRD1, DRD1, DRD3, CRH, HCRT
36nmda45 299.1HCRT, PDYN, DRD3, DRD1, OPRD1
37nitric oxide45 24 1110.1PDYN, DRD1, OPRD1, FAAH, HCRT
38gnrh458.0HCRT, OPRD1, DRD1, CRH, PDYN
39gaba458.0HCRT, PDYN, CRH, OPRD1, DRD1
40acetylcholine45 51 29 24 1112.0HCRT, PDYN, CRH, DRD1, OPRD1
41adenylate457.9HCRT, OPRD1, DRD1, CRH, PDYN
42lipid457.7FAAH, PDYN, HCRT, DARC, OPRD1, DRD1
43opiate457.6CRH, PDYN, DRD3, HCRT, DRD1, OPRD1
44cocaine45 118.6HCRT, OPRD1, DRD1, DRD3, PDYN, CRH
45nicotine45 29 51 1110.6DRD1, HCRT, PDYN, CRH, OPRD1, DRD3
46norepinephrine45 24 119.6CRH, DRD3, DRD1, OPRD1, PDYN, HCRT
47dopamine45 29 24 1110.6PDYN, CRH, DRD3, DRD1, OPRD1, HCRT
48glutamate457.5OPRD1, DRD1, DRD3, PDYN, CRH, HCRT
49tyrosine457.3PDYN, OPRD1, DRD1, DARC, DRD3, FAAH
50calcium45 51 24 1110.2OPRD1, FAAH, HCRT, DRD3, PDYN, DRD1

GO Terms for genes affiliated with Drug Addiction

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16Gene Ontology
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Cellular components related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7OPRD1, DRD1, DRD3, PDYN, DARC

Biological processes related to Drug Addiction according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine uptake involved in synaptic transmissionGO:0515849.9DRD1, DRD3
2dopamine metabolic processGO:0424179.8DRD3, DRD1
3adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.8DRD3, DRD1
4behavioral response to cocaineGO:0481489.8DRD1, DRD3
5prepulse inhibitionGO:0601349.8DRD3, DRD1
6negative regulation of blood pressureGO:0457769.8DRD3, CRH
7response to amphetamineGO:0019759.7DRD3, DRD1
8long-term synaptic potentiationGO:0602919.7DRD1, CRH
9learning or memoryGO:0076119.7DRD3, CRH
10positive regulation of cAMP biosynthetic processGO:0308199.6DRD1, CRH
11response to ethanolGO:0454719.5DRD3, CRH
12visual learningGO:0085429.4DRD1, DRD3
13synaptic transmission, dopaminergicGO:0019639.3DRD1, DRD3, CRH
14phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.3HCRT, OPRD1
15response to drugGO:0424939.2DRD1, DRD3, CRH
16G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.1OPRD1, DRD1
17neuropeptide signaling pathwayGO:0072188.9HCRT, PDYN, OPRD1
18synaptic transmissionGO:0072688.6HCRT, PDYN, CRH

Molecular functions related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.5DRD1, DRD3

Products for genes affiliated with Drug Addiction

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Drug Addiction

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet