MCID: DRG011
MIFTS: 51

Drug Addiction malady

Genetic diseases (common) category

Summaries for Drug Addiction

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MalaCards based summary: Drug Addiction, also known as polysubstance abuse, is related to substance abuse and obesity. An important gene associated with Drug Addiction is FAAH (fatty acid amide hydrolase), and among its related pathways are GPCRs, Other and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and amygdala, and related mouse phenotypes are adipose tissue and growth/size/body.

Description from OMIM:47 606581

Aliases & Classifications for Drug Addiction

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Sources:
47OMIM, 45Novoseek, 62UMLS, 11diseasecard
See all sources

Drug Addiction, Aliases & Descriptions:

Name: Drug Addiction 47 45 62
Polysubstance Abuse 47 45
 
Drug Addiction, Susceptibility to 11


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM47 606581

Related Diseases for Drug Addiction

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Graphical network of the top 20 diseases related to Drug Addiction:



Diseases related to drug addiction

Symptoms for Drug Addiction

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Clinical features from OMIM:

606581

Drugs & Therapeutics for Drug Addiction

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Drug clinical trials:

Search ClinicalTrials for Drug Addiction

Search NIH Clinical Center for Drug Addiction

Genetic Tests for Drug Addiction

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Anatomical Context for Drug Addiction

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MalaCards organs/tissues related to Drug Addiction:

33
Brain, Cortex, Amygdala, Lung, Testes, Prefrontal cortex, Hypothalamus, Pituitary

Animal Models for Drug Addiction or affiliated genes

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MGI Mouse Phenotypes related to Drug Addiction:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9DRD1, DRD3, PDYN
2MP:00053787.6HCRT, PDYN, CRH, DRD3, DRD1
3MP:00107717.5FAAH, PDYN, CRH, DRD1, OPRD1
4MP:00053866.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
5MP:00036316.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
6MP:00053766.5OPRD1, DARC, HCRT, FAAH, PDYN, CRH

Publications for Drug Addiction

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Articles related to Drug Addiction:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. (25823631)
2015
2
The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction. (25838241)
2015
3
Individual differences and vulnerability to drug addiction: a focus on the endocannabinoid system. (25714966)
2015
4
A new proposal for drug conditioning with implications for drug addiction: The Pavlovian two-step from delay to trace conditioning. (25218870)
2014
5
Non-human primate models in drug addiction deserve more attention. (24866486)
2014
6
Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention. (25657617)
2014
7
Stigma, discrimination, treatment effectiveness, and policy: public views about drug addiction and mental illness. (25270497)
2014
8
Drug addiction in pregnancy: disease not moral failure. (24413031)
2014
9
Paying attention to biased attention in drug addiction. (24901505)
2014
10
Epigenetic mechanisms of drug addiction. (23374537)
2013
11
Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing To Drug Addiction: Effect of Ovarian Hormones. (23829370)
2013
12
Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. (22896771)
2012
13
Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers. (21169391)
2011
14
Wearable sensor platform and mobile application for use in cognitive behavioral therapy for drug addiction and PTSD. (22254678)
2011
15
What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? (20846139)
2011
16
Drug addiction, love, and the higher power. (21411471)
2011
17
Animal models of drug addiction in support of novel therapeutic strategies. (23382141)
2011
18
Advances in animal models of drug addiction. (21225413)
2011
19
Novel perspectives on drug addiction and reward. (20493904)
2010
20
The role of executive control in human drug addiction. (21161758)
2010
21
Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. (19307583)
2009
22
Computational approaches to the neurobiology of drug addiction. (19434552)
2009
23
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
24
Drug addiction as a pathology of staged neuroplasticity. (17805308)
2008
25
Sensitization, drug addiction and psychopathology in animals and humans. (17900776)
2007
26
Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis. (16911735)
2006
27
Salt addiction: a different kind of drug addiction. (16790320)
2006
28
Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese? (16759334)
2006
29
Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. (15661634)
2005
30
Synaptic plasticity and drug addiction. (15661621)
2005
31
Novel pharmacotherapeutic targets for the management of drug addiction. (16253234)
2005
32
Neurotrophic mechanisms in drug addiction. (15001814)
2004
33
Detection methods of the drug-addiction and alcoholism treatment programme of the Spanish National Railway Company (RENFE). (14526495)
2003
34
Drug addiction and HIV infection on rise in Tajikistan. (14570036)
2003
35
Parental rearing and individual vulnerability to drug addiction: a controlled study in a Swedish sample. (12745778)
2003
36
Lack of association between parental alcohol or drug addiction and behavioral inhibition in children. (11579013)
2001
37
The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction. (11240309)
2001
38
I have HIV. My #1 disease is drug addiction. (11682999)
2001
39
Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function? (11268408)
2000
40
Report on drug addiction. Reprinted from the Bulletin on the New York Academy of Medicine 1995; 31(8): 592-607. The New York Academy of Medicine Committee on Public Health Subcommittee on Drug Addiction. 1995. (10976618)
2000
41
Drug addiction. (11533766)
2000
42
Safe approaches to treating drug addiction. (10962832)
2000
43
The problem of drug addiction among secondary school students in Lublin. Young people's knowledge about the effects of taking drugs. (11482080)
2000
44
Development of novel medications for drug addiction. The legacy of an African shrub. (10911925)
2000
45
Drug addiction therapy. A dance to the music of time. (10662323)
1999
46
Learning and homeostasis: drug addiction and the McCollough effect. (9747187)
1998
47
Genetic analysis of drug addiction: the role of cAMP response element binding protein. (9500675)
1998
48
Telling the patient the diagnosis of alcoholism or drug addiction: an internist's perspective. (7596240)
1995
49
Drug delivery systems: possible applications in the treatment of drug addiction. (8775840)
1995
50
Nutritional status assessment of HIV-positive drug addicts. (2387276)
1990

Variations for Drug Addiction

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Expression for genes affiliated with Drug Addiction

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Search GEO for disease gene expression data for Drug Addiction.

Pathways for genes affiliated with Drug Addiction

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Pathways related to Drug Addiction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DRD3, DARC
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons38
9.5DRD3, DRD1
3
Show member pathways
9.5DRD1, DRD3
4
Show member pathways
9.3DRD1, PDYN
59.3CRH, PDYN
6
Show member pathways
9.2DRD1, DRD3, FAAH
7
Show member pathways
Peptide GPCRs38
8.8DARC, HCRT, OPRD1
8
Show member pathways
8.8DRD1, CRH, PDYN
9
Show member pathways
6.7DARC, HCRT, PDYN, CRH, DRD3, DRD1
10
Show member pathways
6.7OPRD1, DARC, HCRT, PDYN, CRH, DRD3

Compounds for genes affiliated with Drug Addiction

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Compounds related to Drug Addiction according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cis flupentixol309.8DRD3, DRD1
2eticlopride45 3010.8DRD1, DRD3
3aripiprazole30 45 51 26 1313.6FAAH, DRD3, DRD1
4quetiapine45 51 30 26 1313.6DRD1, DRD3, FAAH
5risperidone45 51 30 61 26 1314.6DRD1, FAAH, DRD3
6sch 23390459.5DRD3, DRD1
7olanzapine45 51 30 26 1313.5FAAH, DRD3, DRD1
8quinpirole45 3010.3DRD3, PDYN, DRD1
96-hydroxydopamine459.3DRD1, PDYN, DRD3
10dermorphin459.2PDYN, OPRD1
11nalmefene45 3010.2PDYN, OPRD1
12amphetamine45 51 1311.2DRD1, HCRT, PDYN
13haloperidol45 51 30 3 1313.1DRD1, HCRT, FAAH, DRD3
14pentazocine45 1310.1OPRD1, PDYN
15atropine45 30 1311.1PDYN, DRD1, CRH
16norbinaltorphimine459.1PDYN, OPRD1
17heroin45 51 1311.0DRD3, PDYN, OPRD1
18npff459.0OPRD1, PDYN, HCRT
19tetrodotoxin45 61 3010.9CRH, HCRT, OPRD1
20levodopa45 139.9DRD1, PDYN, DRD3
21sulpiride45 30 1310.8DRD3, CRH, DRD1, PDYN
22capsaicin45 309.8CRH, PDYN, OPRD1
23clozapine45 30 51 1311.8FAAH, DRD1, OPRD1, DRD3
24[3h]diprenorphine458.7PDYN, OPRD1
25carbachol45 30 1310.6HCRT, OPRD1, CRH, DRD1
26naloxone45 30 51 1311.4DRD1, OPRD1, PDYN, CRH
27acth458.4PDYN, CRH, OPRD1, HCRT
28epinephrine45 26 1310.4OPRD1, HCRT, PDYN, CRH
29potassium45 26 1310.4OPRD1, HCRT, PDYN, DRD3
30catecholamine458.4HCRT, PDYN, CRH, DRD3, DRD1
31alanine458.3HCRT, OPRD1, CRH, FAAH, DARC
32gtp45 309.2DRD3, OPRD1, PDYN, DRD1
33estrogen458.2HCRT, FAAH, PDYN, CRH, DRD1
34methamphetamine45 51 1310.2DRD3, PDYN, FAAH, DRD1, OPRD1
35cyclic amp45 269.1OPRD1, DRD1, DRD3, CRH, HCRT
36nmda45 309.1HCRT, PDYN, DRD3, DRD1, OPRD1
37nitric oxide45 26 1310.1PDYN, DRD1, OPRD1, FAAH, HCRT
38gnrh458.0HCRT, OPRD1, DRD1, CRH, PDYN
39gaba458.0HCRT, PDYN, CRH, OPRD1, DRD1
40acetylcholine45 51 30 26 1312.0HCRT, PDYN, CRH, DRD1, OPRD1
41adenylate457.9HCRT, OPRD1, DRD1, CRH, PDYN
42lipid457.7FAAH, PDYN, HCRT, DARC, OPRD1, DRD1
43opiate457.6CRH, PDYN, DRD3, HCRT, DRD1, OPRD1
44cocaine45 138.6HCRT, OPRD1, DRD1, DRD3, PDYN, CRH
45nicotine45 30 51 1310.6DRD1, HCRT, PDYN, CRH, OPRD1, DRD3
46norepinephrine45 26 139.6CRH, DRD3, DRD1, OPRD1, PDYN, HCRT
47dopamine45 30 26 1310.6PDYN, CRH, DRD3, DRD1, OPRD1, HCRT
48glutamate457.5OPRD1, DRD1, DRD3, PDYN, CRH, HCRT
49tyrosine457.3PDYN, OPRD1, DRD1, DARC, DRD3, FAAH
50calcium45 51 26 1310.2OPRD1, FAAH, HCRT, DRD3, PDYN, DRD1

GO Terms for genes affiliated with Drug Addiction

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Cellular components related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.7OPRD1, DRD1, DRD3, PDYN, DARC

Biological processes related to Drug Addiction according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine uptake involved in synaptic transmissionGO:00515849.9DRD1, DRD3
2dopamine metabolic processGO:00424179.8DRD3, DRD1
3adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.8DRD3, DRD1
4behavioral response to cocaineGO:00481489.8DRD1, DRD3
5prepulse inhibitionGO:00601349.8DRD3, DRD1
6negative regulation of blood pressureGO:00457769.8DRD3, CRH
7response to amphetamineGO:00019759.7DRD3, DRD1
8long-term synaptic potentiationGO:00602919.7DRD1, CRH
9learning or memoryGO:00076119.7DRD3, CRH
10positive regulation of cAMP biosynthetic processGO:00308199.6DRD1, CRH
11response to ethanolGO:00454719.5DRD3, CRH
12visual learningGO:00085429.4DRD1, DRD3
13synaptic transmission, dopaminergicGO:00019639.3DRD1, DRD3, CRH
14phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.3HCRT, OPRD1
15response to drugGO:00424939.2DRD1, DRD3, CRH
16G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.1OPRD1, DRD1
17neuropeptide signaling pathwayGO:00072188.9HCRT, PDYN, OPRD1
18synaptic transmissionGO:00072688.6HCRT, PDYN, CRH

Molecular functions related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:00352409.5DRD1, DRD3

Products for genes affiliated with Drug Addiction

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Sources for Drug Addiction

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet