MCID: DRG011
MIFTS: 45

Drug Addiction malady

Genetic diseases (common) category

Aliases & Classifications for Drug Addiction

About this section
Sources:
46OMIM, 44Novoseek, 61UMLS, 9diseasecard
See all sources

Aliases & Descriptions for Drug Addiction:

Name: Drug Addiction 46 44
Polysubstance Abuse 46 44 61
Drug Addiction, Susceptibility to 9
 
Substance Dependence 61
Drug Dependence 61


Classifications:



External Ids:

OMIM46 606581

Summaries for Drug Addiction

About this section
MalaCards based summary: Drug Addiction, also known as polysubstance abuse, is related to substance abuse and pathological gambling. An important gene associated with Drug Addiction is FAAH (fatty acid amide hydrolase), and among its related pathways are GPCRs, Other and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds cis flupentixol and eticlopride have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and amygdala, and related mouse phenotypes are adipose tissue and growth/size/body.

Description from OMIM:46 606581

Related Diseases for Drug Addiction

About this section

Diseases related to Drug Addiction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1substance abuse30.8CRH, DRD3
2pathological gambling30.7DRD1, DRD3
3substance dependence30.5PDYN, DRD3
4cocaine dependence30.3PDYN, DRD3
5obesity30.3FAAH, HCRT, CRH
6eating disorder30.2HCRT, CRH
7obsessive-compulsive disorder30.0PDYN, DRD3, DRD1
8alcohol dependence29.8OPRD1, CRH, DRD1
9drug dependence29.6PDYN, OPRD1, DRD3, DARC
10schizophrenia29.5PDYN, HCRT, FAAH, DRD3, DRD1
11hepatitis10.6
12neuronitis10.5
13hepatitis c10.5
14cannabis dependence10.4FAAH
15cerebritis10.3
16endocarditis10.3
17mononeuritis multiplex10.2
18mononeuritis10.2
19miliary tuberculosis10.2
20hepatitis d10.2
21melanoma10.2
22osteomyelitis10.2
23tuberculosis10.2
24viral hepatitis10.2
25major depressive disorder and accelerated response to antidepressant drug treatment10.2CRH, DRD3
26parkinson disease, late-onset10.2PDYN, DRD3
27gilles de la tourette syndrome10.2DRD1, DRD3
28withdrawal disorder10.1PDYN, CRH
29narcolepsy10.1HCRT, DRD1
30hepatitis c virus10.1
31myocardial infarction10.1
32malaria10.1
33peliosis hepatis10.1
34pemphigus10.1
35splenic abscess10.1
36plasmodium vivax malaria10.1
37anterior spinal artery syndrome10.1
38carotid artery dissection10.1
39amphetamine abuse10.1
40ecthyma10.1
41cocaine abuse10.1
42panophthalmitis10.1
43penicilliosis10.1
44kwashiorkor10.1
45wound botulism10.1
46arachnoiditis10.1
47necrotizing ulcerative gingivitis10.1
48alcohol-related neurodevelopmental disorder10.1
49fetal alcohol syndrome10.1
50anxiety disorder10.1

Graphical network of the top 20 diseases related to Drug Addiction:



Diseases related to drug addiction

Symptoms for Drug Addiction

About this section


Clinical features from OMIM:

606581

Drugs & Therapeutics for Drug Addiction

About this section

Drug clinical trials:

Search ClinicalTrials for Drug Addiction

Search NIH Clinical Center for Drug Addiction

Genetic Tests for Drug Addiction

About this section

Anatomical Context for Drug Addiction

About this section

MalaCards organs/tissues related to Drug Addiction:

31
Brain, Cortex, Amygdala, Lung, Testes, Prefrontal cortex, Hypothalamus, Pituitary

Animal Models for Drug Addiction or affiliated genes

About this section

MGI Mouse Phenotypes related to Drug Addiction:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9DRD1, DRD3, PDYN
2MP:00053787.6HCRT, PDYN, CRH, DRD3, DRD1
3MP:00107717.5FAAH, PDYN, CRH, DRD1, OPRD1
4MP:00053866.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
5MP:00036316.8HCRT, FAAH, PDYN, CRH, DRD3, DRD1
6MP:00053766.5OPRD1, DARC, HCRT, FAAH, PDYN, CRH

Publications for Drug Addiction

About this section

Articles related to Drug Addiction:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: A systematic review. (25823631)
2015
2
The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction. (25838241)
2015
3
Individual differences and vulnerability to drug addiction: a focus on the endocannabinoid system. (25714966)
2015
4
A new proposal for drug conditioning with implications for drug addiction: The Pavlovian two-step from delay to trace conditioning. (25218870)
2014
5
Non-human primate models in drug addiction deserve more attention. (24866486)
2014
6
Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention. (25657617)
2014
7
Stigma, discrimination, treatment effectiveness, and policy: public views about drug addiction and mental illness. (25270497)
2014
8
Drug addiction in pregnancy: disease not moral failure. (24413031)
2014
9
Paying attention to biased attention in drug addiction. (24901505)
2014
10
Epigenetic mechanisms of drug addiction. (23374537)
2013
11
Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing To Drug Addiction: Effect of Ovarian Hormones. (23829370)
2013
12
Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. (22896771)
2012
13
Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers. (21169391)
2011
14
Wearable sensor platform and mobile application for use in cognitive behavioral therapy for drug addiction and PTSD. (22254678)
2011
15
What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? (20846139)
2011
16
Drug addiction, love, and the higher power. (21411471)
2011
17
Animal models of drug addiction in support of novel therapeutic strategies. (23382141)
2011
18
Advances in animal models of drug addiction. (21225413)
2011
19
Novel perspectives on drug addiction and reward. (20493904)
2010
20
The role of executive control in human drug addiction. (21161758)
2010
21
Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. (19307583)
2009
22
Computational approaches to the neurobiology of drug addiction. (19434552)
2009
23
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
24
Drug addiction as a pathology of staged neuroplasticity. (17805308)
2008
25
Sensitization, drug addiction and psychopathology in animals and humans. (17900776)
2007
26
Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis. (16911735)
2006
27
Salt addiction: a different kind of drug addiction. (16790320)
2006
28
Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese? (16759334)
2006
29
Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. (15661634)
2005
30
Synaptic plasticity and drug addiction. (15661621)
2005
31
Novel pharmacotherapeutic targets for the management of drug addiction. (16253234)
2005
32
Neurotrophic mechanisms in drug addiction. (15001814)
2004
33
Detection methods of the drug-addiction and alcoholism treatment programme of the Spanish National Railway Company (RENFE). (14526495)
2003
34
Drug addiction and HIV infection on rise in Tajikistan. (14570036)
2003
35
Parental rearing and individual vulnerability to drug addiction: a controlled study in a Swedish sample. (12745778)
2003
36
Lack of association between parental alcohol or drug addiction and behavioral inhibition in children. (11579013)
2001
37
The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction. (11240309)
2001
38
I have HIV. My #1 disease is drug addiction. (11682999)
2001
39
Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function? (11268408)
2000
40
Report on drug addiction. Reprinted from the Bulletin on the New York Academy of Medicine 1995; 31(8): 592-607. The New York Academy of Medicine Committee on Public Health Subcommittee on Drug Addiction. 1995. (10976618)
2000
41
Drug addiction. (11533766)
2000
42
Safe approaches to treating drug addiction. (10962832)
2000
43
The problem of drug addiction among secondary school students in Lublin. Young people's knowledge about the effects of taking drugs. (11482080)
2000
44
Development of novel medications for drug addiction. The legacy of an African shrub. (10911925)
2000
45
Drug addiction therapy. A dance to the music of time. (10662323)
1999
46
Learning and homeostasis: drug addiction and the McCollough effect. (9747187)
1998
47
Genetic analysis of drug addiction: the role of cAMP response element binding protein. (9500675)
1998
48
Telling the patient the diagnosis of alcoholism or drug addiction: an internist's perspective. (7596240)
1995
49
Drug delivery systems: possible applications in the treatment of drug addiction. (8775840)
1995
50
Nutritional status assessment of HIV-positive drug addicts. (2387276)
1990

Variations for Drug Addiction

About this section

Expression for genes affiliated with Drug Addiction

About this section
Search GEO for disease gene expression data for Drug Addiction.

Pathways for genes affiliated with Drug Addiction

About this section

Pathways related to Drug Addiction according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DRD3, DARC
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons36
9.5DRD3, DRD1
3
Show member pathways
9.5DRD1, DRD3
4
Show member pathways
9.3DRD1, PDYN
5
Show member pathways
9.2DRD1, DRD3, FAAH
6
Show member pathways
8.8DRD1, CRH, PDYN
7
Show member pathways
6.7DARC, HCRT, PDYN, CRH, DRD3, DRD1
8
Show member pathways
6.7OPRD1, DARC, HCRT, PDYN, CRH, DRD3

Compounds for genes affiliated with Drug Addiction

About this section

Compounds related to Drug Addiction according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1cis flupentixol289.8DRD3, DRD1
2eticlopride44 2810.8DRD1, DRD3
3aripiprazole28 44 50 24 1113.6FAAH, DRD3, DRD1
4quetiapine44 50 28 24 1113.6DRD1, DRD3, FAAH
5risperidone44 50 28 60 24 1114.6DRD1, FAAH, DRD3
6olanzapine44 50 28 24 1113.5FAAH, DRD3, DRD1
7quinpirole44 2810.3DRD3, PDYN, DRD1
86-hydroxydopamine449.3DRD1, PDYN, DRD3
9(+)-butaclamol44 2810.2DRD1, DRD3
10dermorphin449.2PDYN, OPRD1
11nalmefene44 2810.2PDYN, OPRD1
12amphetamine44 50 1111.2DRD1, HCRT, PDYN
13haloperidol44 50 28 1 1113.1DRD1, HCRT, FAAH, DRD3
14norbinaltorphimine449.1PDYN, OPRD1
15atropine44 28 1111.1PDYN, DRD1, CRH
16pentazocine44 1110.1PDYN, OPRD1
17[3h]diprenorphine449.0PDYN, OPRD1
18heroin44 50 1111.0DRD3, PDYN, OPRD1
19npff449.0OPRD1, PDYN, HCRT
20tetrodotoxin44 60 2810.9CRH, HCRT, OPRD1
21levodopa44 119.9DRD1, PDYN, DRD3
22sulpiride44 28 1110.8DRD3, CRH, DRD1, PDYN
23capsaicin44 289.8CRH, PDYN, OPRD1
24clozapine44 28 50 1111.8FAAH, DRD1, OPRD1, DRD3
25carbachol44 28 1110.6HCRT, OPRD1, CRH, DRD1
26naloxone44 28 50 1111.4DRD1, OPRD1, PDYN, CRH
27acth448.4PDYN, CRH, OPRD1, HCRT
28epinephrine44 24 1110.4OPRD1, HCRT, PDYN, CRH
29potassium44 24 1110.4OPRD1, HCRT, PDYN, DRD3
30catecholamine448.4HCRT, PDYN, CRH, DRD3, DRD1
31alanine448.3HCRT, OPRD1, CRH, FAAH, DARC
32gtp44 289.2DRD3, DRD1, OPRD1, PDYN
33estrogen448.2HCRT, FAAH, PDYN, CRH, DRD1
34methamphetamine44 50 1110.2DRD3, PDYN, FAAH, DRD1, OPRD1
35cyclic amp44 249.1OPRD1, DRD1, DRD3, CRH, HCRT
36nmda44 289.1HCRT, PDYN, DRD3, DRD1, OPRD1
37nitric oxide44 24 1110.1PDYN, DRD1, OPRD1, FAAH, HCRT
38gnrh448.0HCRT, OPRD1, DRD1, CRH, PDYN
39gaba448.0HCRT, PDYN, CRH, OPRD1, DRD1
40acetylcholine44 50 28 24 1112.0HCRT, PDYN, CRH, DRD1, OPRD1
41adenylate447.9HCRT, OPRD1, DRD1, CRH, PDYN
42lipid447.7FAAH, PDYN, HCRT, DARC, OPRD1, DRD1
43opiate447.6CRH, PDYN, DRD3, HCRT, DRD1, OPRD1
44cocaine44 118.6HCRT, OPRD1, DRD1, DRD3, PDYN, CRH
45nicotine44 28 50 1110.6DRD1, HCRT, PDYN, CRH, OPRD1, DRD3
46norepinephrine44 24 119.6CRH, DRD3, DRD1, OPRD1, PDYN, HCRT
47dopamine44 28 24 1110.6PDYN, CRH, DRD3, DRD1, OPRD1, HCRT
48glutamate447.5OPRD1, DRD1, DRD3, PDYN, CRH, HCRT
49tyrosine447.3PDYN, OPRD1, DRD1, DARC, DRD3, FAAH
50calcium44 50 24 1110.2PDYN, DRD3, OPRD1, FAAH, DRD1, HCRT

GO Terms for genes affiliated with Drug Addiction

About this section

Cellular components related to Drug Addiction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.7OPRD1, DRD1, DRD3, PDYN, DARC

Biological processes related to Drug Addiction according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine uptake involved in synaptic transmissionGO:00515849.9DRD1, DRD3
2dopamine metabolic processGO:00424179.8DRD3, DRD1
3adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.8DRD3, DRD1
4behavioral response to cocaineGO:00481489.8DRD1, DRD3
5prepulse inhibitionGO:00601349.8DRD3, DRD1
6negative regulation of blood pressureGO:00457769.8DRD3, CRH
7response to amphetamineGO:00019759.7DRD3, DRD1
8long-term synaptic potentiationGO:00602919.7DRD1, CRH
9learning or memoryGO:00076119.7DRD3, CRH
10positive regulation of cAMP biosynthetic processGO:00308199.6DRD1, CRH
11response to ethanolGO:00454719.5DRD3, CRH
12visual learningGO:00085429.4DRD1, DRD3
13synaptic transmission, dopaminergicGO:00019639.3DRD1, DRD3, CRH
14phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.3HCRT, OPRD1
15response to drugGO:00424939.2DRD1, DRD3, CRH
16G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.1OPRD1, DRD1
17neuropeptide signaling pathwayGO:00072188.9HCRT, PDYN, OPRD1
18synaptic transmissionGO:00072688.6HCRT, PDYN, CRH

Molecular functions related to Drug Addiction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:00352409.5DRD1, DRD3

Sources for Drug Addiction

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet