MCID: DRG011
MIFTS: 47

Drug Addiction malady

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Summaries for Drug Addiction

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Wikipedia:65 Substance dependence is an readaptive state that develops from repeated drug administration, and which... more...

MalaCards based summary: Drug Addiction is related to substance abuse and pathological gambling. An important gene associated with Drug Addiction is FAAH (fatty acid amide hydrolase), and among its related pathways are GPCRs, Other and Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics. The compounds eticlopride and cis flupentixol have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and amygdala, and related mouse phenotypes are adipose tissue and growth/size/body.

Description from OMIM:46 606581

Aliases & Classifications for Drug Addiction

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Drug Addiction, Aliases & Descriptions:

Name: Drug Addiction 46 44 62


Related Diseases for Drug Addiction

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Graphical network of the top 20 diseases related to Drug Addiction:



Diseases related to drug addiction

Symptoms for Drug Addiction

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Clinical features from OMIM:

606581

Drugs & Therapeutics for Drug Addiction

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Drug clinical trials:

Search ClinicalTrials for Drug Addiction

Search NIH Clinical Center for Drug Addiction

Genetic Tests for Drug Addiction

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Anatomical Context for Drug Addiction

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MalaCards organs/tissues related to Drug Addiction:

32
Brain, Cortex, Amygdala, Lung, Testes, Prefrontal cortex, Hypothalamus, Pituitary

Animal Models for Drug Addiction or affiliated genes

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MGI Mouse Phenotypes related to Drug Addiction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.9PDYN, DRD3, DRD1
2MP:00053787.6DRD1, DRD3, CRH, PDYN, HCRT
3MP:00107717.5FAAH, OPRD1, DRD1, CRH, PDYN
4MP:00053866.8PDYN, OPRD1, DRD1, FAAH, DRD3, HCRT
5MP:00036316.8OPRD1, DRD1, DRD3, CRH, PDYN, FAAH
6MP:00053766.5HCRT, DARC, FAAH, PDYN, CRH, DRD3

Publications for Drug Addiction

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Articles related to Drug Addiction:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
A new proposal for drug conditioning with implications for drug addiction: The Pavlovian two-step from delay to trace conditioning. (25218870)
2014
2
Non-human primate models in drug addiction deserve more attention. (24866486)
2014
3
Stigma, discrimination, treatment effectiveness, and policy: public views about drug addiction and mental illness. (25270497)
2014
4
Drug addiction in pregnancy: disease not moral failure. (24413031)
2014
5
Paying attention to biased attention in drug addiction. (24901505)
2014
6
Epigenetic mechanisms of drug addiction. (23374537)
2013
7
Male and Female Rats Differ in Brain Cannabinoid CB1 Receptor Density and Function and in Behavioural Traits Predisposing To Drug Addiction: Effect of Ovarian Hormones. (23829370)
2013
8
Gene Silencing of Human Neuronal Cells for Drug Addiction Therapy using Anisotropic Nanocrystals. (22896771)
2012
9
Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers. (21169391)
2011
10
Wearable sensor platform and mobile application for use in cognitive behavioral therapy for drug addiction and PTSD. (22254678)
2011
11
What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? (20846139)
2011
12
Drug addiction, love, and the higher power. (21411471)
2011
13
Animal models of drug addiction in support of novel therapeutic strategies. (23382141)
2011
14
Advances in animal models of drug addiction. (21225413)
2011
15
Novel perspectives on drug addiction and reward. (20493904)
2010
16
The role of executive control in human drug addiction. (21161758)
2010
17
Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. (19307583)
2009
18
Computational approaches to the neurobiology of drug addiction. (19434552)
2009
19
Traditional medicine in the treatment of drug addiction. (19152199)
2009
20
Drug addiction as a brain disorder or disease. (19436014)
2009
21
Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. (18482945)
2008
22
Drug addiction as a pathology of staged neuroplasticity. (17805308)
2008
23
Sensitization, drug addiction and psychopathology in animals and humans. (17900776)
2007
24
Puffy hand syndrome due to drug addiction: a case-control study of the pathogenesis. (16911735)
2006
25
Salt addiction: a different kind of drug addiction. (16790320)
2006
26
Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese? (16759334)
2006
27
Involvement of the endocannabinoid system in drug addiction. (16483675)
2006
28
Novel pharmacotherapeutic approaches for the treatment of drug addiction and craving. (15661634)
2005
29
Synaptic plasticity and drug addiction. (15661621)
2005
30
Novel pharmacotherapeutic targets for the management of drug addiction. (16253234)
2005
31
Neurotrophic mechanisms in drug addiction. (15001814)
2004
32
Detection methods of the drug-addiction and alcoholism treatment programme of the Spanish National Railway Company (RENFE). (14526495)
2003
33
Drug addiction and HIV infection on rise in Tajikistan. (14570036)
2003
34
Parental rearing and individual vulnerability to drug addiction: a controlled study in a Swedish sample. (12745778)
2003
35
U.S. Supreme Court to review drug addiction case. (14593342)
2003
36
Lack of association between parental alcohol or drug addiction and behavioral inhibition in children. (11579013)
2001
37
The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction. (11240309)
2001
38
I have HIV. My #1 disease is drug addiction. (11682999)
2001
39
Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function? (11268408)
2000
40
Report on drug addiction. Reprinted from the Bulletin on the New York Academy of Medicine 1995; 31(8): 592-607. The New York Academy of Medicine Committee on Public Health Subcommittee on Drug Addiction. 1995. (10976618)
2000
41
Drug addiction. (11533766)
2000
42
Safe approaches to treating drug addiction. (10962832)
2000
43
The problem of drug addiction among secondary school students in Lublin. Young people's knowledge about the effects of taking drugs. (11482080)
2000
44
Development of novel medications for drug addiction. The legacy of an African shrub. (10911925)
2000
45
Drug addiction therapy. A dance to the music of time. (10662323)
1999
46
Learning and homeostasis: drug addiction and the McCollough effect. (9747187)
1998
47
Genetic analysis of drug addiction: the role of cAMP response element binding protein. (9500675)
1998
48
Telling the patient the diagnosis of alcoholism or drug addiction: an internist's perspective. (7596240)
1995
49
Drug delivery systems: possible applications in the treatment of drug addiction. (8775840)
1995
50
Nutritional status assessment of HIV-positive drug addicts. (2387276)
1990

Variations for Drug Addiction

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Expression for genes affiliated with Drug Addiction

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Expression patterns in normal tissues for genes affiliated with Drug Addiction

Search GEO for disease gene expression data for Drug Addiction.

Pathways for genes affiliated with Drug Addiction

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Pathways related to Drug Addiction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7DRD3, DARC
2
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.5DRD3, DRD1
3
Show member pathways
9.5DRD1, DRD3
4
Show member pathways
9.3DRD1, PDYN
59.3CRH, PDYN
6
Show member pathways
9.2DRD1, DRD3, FAAH
7
Show member pathways
Peptide GPCRs37
8.8DARC, HCRT, OPRD1
8
Show member pathways
8.8DRD1, CRH, PDYN
9
Show member pathways
6.7DARC, HCRT, PDYN, CRH, DRD3, DRD1
10
Show member pathways
6.7OPRD1, DARC, HCRT, PDYN, CRH, DRD3

Compounds for genes affiliated with Drug Addiction

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Compounds related to Drug Addiction according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1eticlopride44 2810.8DRD1, DRD3
2cis flupentixol289.8DRD1, DRD3
3aripiprazole28 44 50 24 1113.6FAAH, DRD3, DRD1
4quetiapine44 50 28 24 1113.6FAAH, DRD3, DRD1
5risperidone44 50 28 61 24 1114.6FAAH, DRD3, DRD1
6olanzapine44 50 28 24 1113.5FAAH, DRD3, DRD1
7quinpirole44 2810.3DRD1, DRD3, PDYN
86-hydroxydopamine449.3DRD1, DRD3, PDYN
9sch 23390449.2DRD1, DRD3
10dermorphin449.2PDYN, OPRD1
11nalmefene44 2810.2PDYN, OPRD1
12amphetamine44 50 1111.2HCRT, PDYN, DRD1
13haloperidol44 50 28 2 1113.1DRD1, DRD3, FAAH, HCRT
14norbinaltorphimine449.1OPRD1, PDYN
15atropine44 28 1111.1DRD1, CRH, PDYN
16pentazocine44 1110.1OPRD1, PDYN
17[3h]diprenorphine449.0OPRD1, PDYN
18heroin44 50 1111.0OPRD1, DRD3, PDYN
19npff449.0HCRT, PDYN, OPRD1
20tetrodotoxin44 61 2810.9HCRT, CRH, OPRD1
21levodopa44 119.9PDYN, DRD3, DRD1
22sulpiride44 28 1110.8PDYN, CRH, DRD3, DRD1
23capsaicin44 289.8PDYN, CRH, OPRD1
24clozapine44 28 50 1111.8FAAH, DRD3, DRD1, OPRD1
25carbachol44 28 1110.6HCRT, CRH, DRD1, OPRD1
26naloxone44 28 50 1111.4OPRD1, DRD1, CRH, PDYN
27acth448.4OPRD1, CRH, PDYN, HCRT
28epinephrine44 24 1110.4OPRD1, CRH, PDYN, HCRT
29potassium44 24 1110.4HCRT, PDYN, DRD3, OPRD1
30catecholamine448.4HCRT, PDYN, CRH, DRD3, DRD1
31alanine448.3OPRD1, CRH, FAAH, HCRT, DARC
32gtp44 289.2PDYN, DRD3, DRD1, OPRD1
33estrogen448.2DRD1, CRH, PDYN, FAAH, HCRT
34methamphetamine44 50 1110.2FAAH, PDYN, DRD3, DRD1, OPRD1
35cyclic amp44 249.1HCRT, CRH, DRD3, DRD1, OPRD1
36nmda44 289.1HCRT, PDYN, DRD3, DRD1, OPRD1
37nitric oxide44 24 1110.1HCRT, FAAH, PDYN, DRD1, OPRD1
38gnrh448.0HCRT, PDYN, CRH, DRD1, OPRD1
39gaba448.0OPRD1, DRD1, CRH, PDYN, HCRT
40acetylcholine44 50 28 24 1112.0HCRT, PDYN, CRH, DRD1, OPRD1
41adenylate447.9HCRT, PDYN, CRH, DRD1, OPRD1
42lipid447.7DARC, HCRT, FAAH, PDYN, DRD1, OPRD1
43opiate447.6OPRD1, DRD1, DRD3, CRH, PDYN, HCRT
44cocaine44 118.6HCRT, PDYN, CRH, DRD3, DRD1, OPRD1
45nicotine44 28 50 1110.6HCRT, PDYN, CRH, DRD3, DRD1, OPRD1
46norepinephrine44 24 119.6HCRT, PDYN, CRH, DRD3, DRD1, OPRD1
47dopamine44 28 24 1110.6HCRT, PDYN, CRH, DRD3, DRD1, OPRD1
48glutamate447.5HCRT, PDYN, CRH, DRD3, DRD1, OPRD1
49tyrosine447.3DARC, HCRT, FAAH, PDYN, DRD3, DRD1
50calcium44 50 24 1110.2HCRT, FAAH, PDYN, DRD3, DRD1, OPRD1

GO Terms for genes affiliated with Drug Addiction

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Cellular components related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7OPRD1, DRD1, DRD3, PDYN, DARC

Biological processes related to Drug Addiction according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of dopamine uptake involved in synaptic transmissionGO:0515849.9DRD1, DRD3
2dopamine metabolic processGO:0424179.8DRD3, DRD1
3adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.8DRD3, DRD1
4behavioral response to cocaineGO:0481489.8DRD1, DRD3
5prepulse inhibitionGO:0601349.8DRD3, DRD1
6negative regulation of blood pressureGO:0457769.8DRD3, CRH
7response to amphetamineGO:0019759.7DRD3, DRD1
8long-term synaptic potentiationGO:0602919.7DRD1, CRH
9learning or memoryGO:0076119.7DRD3, CRH
10positive regulation of cAMP biosynthetic processGO:0308199.6DRD1, CRH
11response to ethanolGO:0454719.5DRD3, CRH
12visual learningGO:0085429.4DRD1, DRD3
13synaptic transmission, dopaminergicGO:0019639.3DRD1, DRD3, CRH
14phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.3HCRT, OPRD1
15response to drugGO:0424939.2DRD1, DRD3, CRH
16G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.1OPRD1, DRD1
17neuropeptide signaling pathwayGO:0072188.9HCRT, PDYN, OPRD1
18synaptic transmissionGO:0072688.6HCRT, PDYN, CRH

Molecular functions related to Drug Addiction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:0352409.5DRD1, DRD3

Products for genes affiliated with Drug Addiction

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  • Antibodies
  • Proteins
  • Lysates

Sources for Drug Addiction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet