MCID: DRG003
MIFTS: 41

Drug Dependence malady

Summaries for Drug Dependence

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Disease Ontology:9 A substance dependence that involves the continued use of drugs despite problems related to use of the substance.

MalaCards based summary: Drug Dependence, also known as substance dependence, is related to substance dependence and alcohol dependence. An important gene associated with Drug Dependence is OPRL1 (opiate receptor-like 1), and among its related pathways are Monoamine GPCRs and GPCRs, Other. The compounds spiradoline and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and cortex, and related mouse phenotypes are nervous system and integument.

Aliases & Classifications for Drug Dependence

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Drug Dependence, Aliases & Descriptions:

Name: Drug Dependence 9 43 60
 
Substance Dependence 60


External Ids:

Disease Ontology9 DOID:9974
ICD9CM27 304.6, 304.60

Related Diseases for Drug Dependence

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Diseases related to Drug Dependence via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1substance dependence30.7PDYN, DRD3
2alcohol dependence30.2CHRM2, OPRD1, OPRK1
3obsessive-compulsive disorder30.1DRD3, PDYN
4cocaine dependence30.1OPRK1, DRD3, PDYN
5opioid dependence29.7OPRK1, OPRD1, DRD3, PDYN
6drug addiction29.4DARC, PDYN, DRD3, OPRD1, OPRK1
7schizophrenia29.3OPRK1, DRD3, PDYN, CHRM2
8personality disorder10.3
9conduct disorder10.2
10chronic pain10.2
11hepatitis10.2
12cerebritis10.2
13headache10.2
14psychotic disorder10.1PDYN, DRD3
15asthma10.1
16obesity10.1
17hiv-110.1
18thrombocytopenia10.1
19hepatitis c10.1
20borderline personality disorder10.1
21neonatal abstinence syndrome10.1
22post-traumatic stress disorder10.1
23social phobia10.1
24anxiety disorder10.1
25encephalitis10.1DARC, PDYN
26mood disorder10.1PDYN, DRD3
27morphine dependence10.1OPRD1, OPRK1
28parkinson disease, late-onset10.0DRD3, PDYN
29pain agnosia10.0OPRK1, OPRL1, PDYN
30prostate cancer9.9
31attention deficit-hyperactivity disorder9.9
32malaria9.9
33anorexia nervosa9.9
34cannabis dependence9.9
35barbiturate dependence9.9
36antisocial personality disorder9.9
37neuronitis9.9
38acquired immunodeficiency syndrome9.9
39hepatitis d9.9
40placental abruption9.9
41cocaine abuse9.9
42hallucinogen dependence9.9
43opiate dependence9.9
44prostatitis9.9
45cluster headache9.9
46exercise induced anaphylaxis9.9
47leukopenia9.9
48blindness9.9
49migraine9.9CHRM2, DRD3
50congestive heart failure9.9PDYN, CHRM2

Graphical network of the top 20 diseases related to Drug Dependence:



Diseases related to drug dependence

Symptoms for Drug Dependence

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Drugs & Therapeutics for Drug Dependence

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Drug clinical trials:

Search ClinicalTrials for Drug Dependence

Search NIH Clinical Center for Drug Dependence

Genetic Tests for Drug Dependence

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Anatomical Context for Drug Dependence

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MalaCards organs/tissues related to Drug Dependence:

31
Testes, Brain, Cortex, Heart, Breast, Prostate, Prefrontal cortex

Animal Models for Drug Dependence or affiliated genes

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MGI Mouse Phenotypes related to Drug Dependence:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7OPRL1, OPRD1, DRD3, PDYN, CHRM2
2MP:00107717.6CHRM2, PDYN, OPRD1, OPRL1, OPRK1
3MP:00053867.2OPRK1, OPRL1, OPRD1, DRD3, PDYN, CHRM2
4MP:00053767.0DARC, CHRM2, PDYN, DRD3, OPRD1, OPRL1

Publications for Drug Dependence

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Articles related to Drug Dependence:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Predictors of alcohol and drug dependence. (25007113)
2014
2
Is there a family profile of addictive behaviors? Family functioning in anorexia nervosa and drug dependence disorder. (23794317)
2014
3
Effects of chronic mild stress on the development of drug dependence in rats. (24949570)
2014
4
The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. (24189487)
2014
5
Neuroimaging in Alcohol and Drug Dependence. (24678450)
2014
6
Problematic alcohol use in clients recovering from drug dependence--time to adjust our focus. (23668295)
2013
7
Child neglect and the development of externalizing behavior problems: associations with maternal drug dependence and neighborhood crime. (23136210)
2013
8
Resting state synchrony in long-term abstinent alcoholics with versus without comorbid drug dependence. (23639390)
2013
9
Neurobiological correlates of the familial risk for stimulant drug dependence. (23147481)
2013
10
Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience. (23523373)
2013
11
The influence of gene-environment interactions on the development of alcoholism and drug dependence. (22367454)
2012
12
An analysis of abstracts presented to the college on problems of drug dependence meeting and subsequent publication in peer review journals. (19889211)
2009
13
The Mountain Council on Alcohol and Drug Dependence. (19534066)
2009
14
Endogenous modulators for drug dependence. (18758051)
2008
15
Drug-dependent boys are more depressed compared to girls: a comorbidity study of substance dependence and mental disorders. (18552492)
2008
16
The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-alpha, and an inducer of these factors in drug dependence. (17538232)
2007
17
The relationship between legal status, perceived pressure and motivation in treatment for drug dependence: results from a European study of Quasi-Compulsory Treatment. (16968995)
2006
18
Lifetime illicit drug use and drug dependence are common by the age of 25 in New Zealand. (16868205)
2006
19
Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. (16622805)
2006
20
Individual differences in drug dependence in rats: the role of genetic factors and life events. (16253227)
2005
21
The role of personality disorders on drug dependence treatment outcomes following inpatient detoxification. (15196598)
2004
22
Treatment of chronic hepatitis C in patients with drug dependence: time to change the rules? (15317637)
2004
23
Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence. (11526463)
2001
24
Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence. (11276551)
2001
25
College on Problems of Drug Dependence. 62nd Annual Scientific Meeting. June 17-22, 2000. San Juan, Puerto Rico. Abstracts. (11252251)
2000
26
Drug dependence in a journal club. (10833978)
2000
27
Problems of drug dependence 1999: Proceedings of the 61st annual scientific meeting, the College on Problems of Drug Dependence, Inc. (11680410)
1999
28
Childhood stress and symptoms of drug dependence in adolescence and early adulthood: social phobia as a mediator. (9990437)
1999
29
Drug dependence scale in the Millon Clinical Multiaxial inventory. (9178439)
1997
30
Elementary particles for models of drug dependence, 10th Okey Memorial Lecture presented at the Institute of Psychiatry, London on 19th March 1997. (9449017)
1997
31
College on Problems of Drug Dependence policy on administering drugs with abuse potential in human research. (11654740)
1996
32
Prevalence and correlates of drug use and DSM-IV drug dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. (8880660)
1996
33
Contract program for veterans with alcohol and drug dependence disorders--VA. Final rule. (10172801)
1996
34
Prescription drug dependence in the elderly population: demographic and clinical features of 100 inpatients. (7967773)
1994
35
Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. (8018097)
1994
36
Neurochemistry of Drug Dependence. Proceedings of Biochemical Society Symposium No. 59. London, December 1992. (7910737)
1993
37
Components of drug dependence: reinforcement, discrimination and adaptation. (8192682)
1993
38
Drug dependence in prisoners. (2025727)
1991
39
Drug dependence and pregnancy: antenatal and intrapartum problems. (2221329)
1990
40
Brief history of control, prevention and treatment of drug dependence in Japan. (2183987)
1990
41
Towards freedom: treatment approaches to drug dependence at TTK Hospital. (2611423)
1989
42
The therapeutic community model in the treatment of drug dependence: its advantages and disadvantages. (2509837)
1989
43
Problems of drug dependence, 1988. Proceedings of the 50th annual scientific meeting, the Committee on Problems of Drug Dependence, Inc. North Falmouth, Massachusetts, June 1988. (3151918)
1988
44
Alcohol and other drug dependence among latinos. (18750251)
1987
45
Biological evaluation of compounds for their physical dependence potential and abuse liability. IX. Drug Testing Program of the Committee on Problems of Drug Dependence, Inc. (1985). (3092095)
1986
46
Evidence for a drug dependence syndrome among narcotic users. (3463347)
1986
47
Role of conditioning factors in the development of drug dependence. (3534813)
1986
48
Drug dependence in pregnancy: intrapartum course and management. (3092082)
1986
49
Prescribing practices for pain in drug dependence: a lesson in ignorance. (2870625)
1985
50
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977

Variations for Drug Dependence

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Expression for genes affiliated with Drug Dependence

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Search GEO for disease gene expression data for Drug Dependence.

Pathways for genes affiliated with Drug Dependence

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Compounds for genes affiliated with Drug Dependence

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Compounds related to Drug Dependence according to GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1spiradoline439.9PDYN, OPRK1
2beta-endorphin289.7OPRD1, OPRK1
3[3h]diprenorphine289.7OPRD1, OPRK1
4(-)-bremazocine289.6OPRD1, OPRK1
5bntx289.6OPRD1, OPRK1
6normorphine289.6OPRK1, OPRD1
7butorphanol43 1210.6OPRK1, OPRD1
8etonitazene289.6OPRK1, OPRD1
9(-)-methadone289.6OPRK1, OPRD1
10alvimopan43 1210.6OPRK1, OPRD1
11carfentanil43 1210.5OPRK1, OPRD1
12dynorphin a-(1-8)289.5OPRD1, OPRK1
13(-)-cyclazocine289.5OPRD1, OPRK1
14beta funaltrexamine439.4OPRK1, OPRD1
15ici 174864439.4OPRD1, OPRK1
16bremazocine439.4OPRD1, OPRL1, OPRK1
17nalbzoh439.4OPRL1, OPRK1, OPRD1
18naltrexone43 28 49 1212.3OPRL1, OPRK1, OPRD1
19naltriben43 2810.3OPRD1, OPRK1
20(-)-ekc289.3OPRK1, OPRD1
21dermorphin439.3OPRK1, OPRD1, PDYN
22nalmefene43 2810.3PDYN, OPRD1, OPRK1
23norbinaltorphimine439.3PDYN, OPRK1, OPRD1
24pentazocine43 1210.3OPRD1, PDYN, OPRK1
25[3h]diprenorphine439.3OPRK1, PDYN, OPRD1
26dpdpe28 43 5911.3OPRK1, OPRD1, PDYN
27tetrapeptide439.3OPRL1, OPRK1, OPRD1
28methadone49 43 1211.3OPRK1, OPRD1, PDYN
29nor-binaltorphimine289.2OPRK1, OPRD1
30naloxone43 28 49 1212.2OPRK1, PDYN, OPRD1
31methamphetamine43 49 1211.2PDYN, DRD3, OPRD1
32dynorphin a-(1-13)289.0OPRK1, OPRD1
33damgo43 28 5911.0PDYN, OPRD1, OPRK1, OPRL1
34etorphine43 28 1211.0OPRK1, OPRL1, OPRD1, PDYN
35buprenorphine43 28 1210.9PDYN, OPRL1, OPRK1, OPRD1
36morphine43 49 28 1211.9OPRL1, OPRK1, OPRD1, PDYN
37amitriptyline43 28 49 1211.9OPRK1, CHRM2, OPRD1
38heroin43 49 1210.8PDYN, DRD3, OPRK1, OPRD1
39nmda43 289.7OPRK1, DRD3, OPRD1, PDYN
40gaba438.4CHRM2, OPRD1, PDYN, OPRK1
41clozapine43 28 49 1211.4DRD3, OPRD1, OPRK1, CHRM2
42acetylcholine43 49 28 24 1212.4OPRK1, OPRD1, CHRM2, PDYN
43cyclic amp43 249.0OPRL1, OPRK1, DRD3, CHRM2, OPRD1
44cocaine43 129.0OPRD1, OPRK1, PDYN, DRD3, CHRM2
45nicotine43 28 49 1211.0OPRK1, DRD3, PDYN, CHRM2, OPRD1
46potassium43 24 129.9CHRM2, PDYN, DRD3, OPRD1, OPRK1
47opiate437.6OPRD1, DRD3, CHRM2, PDYN, OPRK1, OPRL1
48norepinephrine43 24 129.6CHRM2, DRD3, OPRK1, OPRD1, PDYN, OPRL1
49gtp43 288.6CHRM2, PDYN, DRD3, OPRK1, OPRD1, OPRL1
50tyrosine437.2OPRK1, PDYN, DARC, CHRM2, DRD3, OPRD1

GO Terms for genes affiliated with Drug Dependence

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Cellular components related to Drug Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058877.6OPRK1, OPRL1, OPRD1, DRD3, CHRM2
2plasma membraneGO:00058866.4OPRK1, DARC, CHRM2, PDYN, DRD3, OPRD1

Biological processes related to Drug Dependence according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:00076009.8OPRK1, OPRL1
2behaviorGO:00076109.7OPRK1, OPRL1
3sensory perception of painGO:00192339.5OPRL1, OPRK1
4phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.4OPRK1, OPRD1
5neuropeptide signaling pathwayGO:00072189.4OPRD1, PDYN
6opioid receptor signaling pathwayGO:00380039.2OPRK1, OPRL1, OPRD1
7adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00071939.2OPRD1, OPRL1, OPRK1
8locomotory behaviorGO:00076269.1OPRK1, DRD3
9G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.0OPRD1, CHRM2
10G-protein coupled receptor signaling pathwayGO:00071868.6CHRM2, DRD3, OPRD1

Molecular functions related to Drug Dependence according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1opioid receptor activityGO:00049859.3OPRK1, OPRD1

Products for genes affiliated with Drug Dependence

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Sources for Drug Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet