MCID: DRG003
MIFTS: 49

Drug Dependence malady

Mental diseases category
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Summaries for Drug Dependence

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Disease Ontology:8 A substance dependence that involves the continued use of drugs despite despite problems related to use of the substance.

MalaCards based summary: Drug Dependence is related to substance dependence and alcohol dependence. An important gene associated with Drug Dependence is OPRL1 (opiate receptor-like 1), and among its related pathways are Monoamine GPCRs and GPCRs, Other. The compounds spiradoline and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and cortex, and related mouse phenotypes are nervous system and integument.

Wikipedia:65 Substance dependence is an readaptive state that develops from repeated drug administration, and which... more...

Aliases & Classifications for Drug Dependence

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Drug Dependence, Aliases & Descriptions:

Name: Drug Dependence 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:9974
ICD9CM27 304.60, 304.6

Related Diseases for Drug Dependence

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Diseases related to Drug Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1substance dependence30.7PDYN, DRD3
2alcohol dependence30.2OPRK1, OPRD1, CHRM2
3obsessive-compulsive disorder30.1PDYN, DRD3
4cocaine dependence30.1PDYN, DRD3, OPRK1
5opiate dependence29.9OPRK1, PDYN, DRD3, OPRD1
6schizophrenia29.3CHRM2, PDYN, DRD3, OPRK1
7alzheimer's disease28.9CHRM2, OPRK1, OPRD1, DRD3, PDYN
8personality disorder10.3
9conduct disorder10.2
10chronic pain10.2
11hepatitis10.2
12heroin dependence10.2
13cerebritis10.2
14headache10.2
15psychotic disorder10.1DRD3, PDYN
16mood disorder10.1DRD3, PDYN
17encephalitis10.1PDYN, DARC
18asthma10.1
19hiv-110.1
20obesity10.1
21thrombocytopenia10.1
22post-traumatic stress disorder10.1
23hepatitis c10.1
24neonatal abstinence syndrome10.1
25borderline personality disorder10.1
26social phobia10.1
27anxiety disorder10.1
28morphine dependence10.1OPRD1, OPRK1
29parkinson's disease10.0PDYN, DRD3
30pain agnosia10.0OPRK1, OPRL1, PDYN
31congestive heart failure9.9PDYN, CHRM2
32attention deficit hyperactivity disorder9.9
33malaria9.9
34prostate cancer9.9
35barbiturate dependence9.9
36bernard-soulier syndrome9.9
37hepatitis d9.9
38cannabis dependence9.9
39acquired immunodeficiency syndrome9.9
40cocaine abuse9.9
41placental abruption9.9
42antisocial personality disorder9.9
43neuronitis9.9
44anorexia nervosa9.9
45hallucinogen dependence9.9
46prostatitis9.9
47cluster headache9.9
48exercise induced anaphylaxis9.9
49leukopenia9.9
50blindness9.9

Graphical network of the top 20 diseases related to Drug Dependence:



Diseases related to drug dependence

Symptoms for Drug Dependence

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Drugs & Therapeutics for Drug Dependence

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Drug clinical trials:

Search ClinicalTrials for Drug Dependence

Search NIH Clinical Center for Drug Dependence

Genetic Tests for Drug Dependence

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Anatomical Context for Drug Dependence

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MalaCards organs/tissues related to Drug Dependence:

32
Testes, Brain, Cortex, Heart, Breast, Prostate, Prefrontal cortex

Animal Models for Drug Dependence or affiliated genes

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MGI Mouse Phenotypes related to Drug Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7OPRL1, OPRD1, DRD3, PDYN, CHRM2
2MP:00107717.6CHRM2, PDYN, OPRD1, OPRL1, OPRK1
3MP:00053867.2OPRK1, OPRL1, OPRD1, DRD3, PDYN, CHRM2
4MP:00053767.0DARC, CHRM2, PDYN, DRD3, OPRD1, OPRL1

Publications for Drug Dependence

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Articles related to Drug Dependence:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Predictors of alcohol and drug dependence. (25007113)
2014
2
Is there a family profile of addictive behaviors? Family functioning in anorexia nervosa and drug dependence disorder. (23794317)
2014
3
Effects of chronic mild stress on the development of drug dependence in rats. (24949570)
2014
4
The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. (24189487)
2014
5
Neuroimaging in Alcohol and Drug Dependence. (24678450)
2014
6
Problematic alcohol use in clients recovering from drug dependence--time to adjust our focus. (23668295)
2013
7
Child neglect and the development of externalizing behavior problems: associations with maternal drug dependence and neighborhood crime. (23136210)
2013
8
Resting state synchrony in long-term abstinent alcoholics with versus without comorbid drug dependence. (23639390)
2013
9
Neurobiological correlates of the familial risk for stimulant drug dependence. (23147481)
2013
10
Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience. (23523373)
2013
11
The influence of gene-environment interactions on the development of alcoholism and drug dependence. (22367454)
2012
12
An analysis of abstracts presented to the college on problems of drug dependence meeting and subsequent publication in peer review journals. (19889211)
2009
13
The Mountain Council on Alcohol and Drug Dependence. (19534066)
2009
14
Endogenous modulators for drug dependence. (18758051)
2008
15
Drug-dependent boys are more depressed compared to girls: a comorbidity study of substance dependence and mental disorders. (18552492)
2008
16
The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-alpha, and an inducer of these factors in drug dependence. (17538232)
2007
17
The relationship between legal status, perceived pressure and motivation in treatment for drug dependence: results from a European study of Quasi-Compulsory Treatment. (16968995)
2006
18
Lifetime illicit drug use and drug dependence are common by the age of 25 in New Zealand. (16868205)
2006
19
Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. (16622805)
2006
20
Individual differences in drug dependence in rats: the role of genetic factors and life events. (16253227)
2005
21
The role of personality disorders on drug dependence treatment outcomes following inpatient detoxification. (15196598)
2004
22
Treatment of chronic hepatitis C in patients with drug dependence: time to change the rules? (15317637)
2004
23
Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence. (11526463)
2001
24
Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence. (11276551)
2001
25
College on Problems of Drug Dependence. 62nd Annual Scientific Meeting. June 17-22, 2000. San Juan, Puerto Rico. Abstracts. (11252251)
2000
26
Drug dependence in a journal club. (10833978)
2000
27
Problems of drug dependence 1999: Proceedings of the 61st annual scientific meeting, the College on Problems of Drug Dependence, Inc. (11680410)
1999
28
Childhood stress and symptoms of drug dependence in adolescence and early adulthood: social phobia as a mediator. (9990437)
1999
29
Drug dependence scale in the Millon Clinical Multiaxial inventory. (9178439)
1997
30
Elementary particles for models of drug dependence, 10th Okey Memorial Lecture presented at the Institute of Psychiatry, London on 19th March 1997. (9449017)
1997
31
College on Problems of Drug Dependence policy on administering drugs with abuse potential in human research. (11654740)
1996
32
Prevalence and correlates of drug use and DSM-IV drug dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. (8880660)
1996
33
Contract program for veterans with alcohol and drug dependence disorders--VA. Final rule. (10172801)
1996
34
Prescription drug dependence in the elderly population: demographic and clinical features of 100 inpatients. (7967773)
1994
35
Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. (8018097)
1994
36
Neurochemistry of Drug Dependence. Proceedings of Biochemical Society Symposium No. 59. London, December 1992. (7910737)
1993
37
Components of drug dependence: reinforcement, discrimination and adaptation. (8192682)
1993
38
Drug dependence in prisoners. (2025727)
1991
39
Drug dependence and pregnancy: antenatal and intrapartum problems. (2221329)
1990
40
Brief history of control, prevention and treatment of drug dependence in Japan. (2183987)
1990
41
Towards freedom: treatment approaches to drug dependence at TTK Hospital. (2611423)
1989
42
The therapeutic community model in the treatment of drug dependence: its advantages and disadvantages. (2509837)
1989
43
Problems of drug dependence, 1988. Proceedings of the 50th annual scientific meeting, the Committee on Problems of Drug Dependence, Inc. North Falmouth, Massachusetts, June 1988. (3151918)
1988
44
Alcohol and other drug dependence among latinos. (18750251)
1987
45
Biological evaluation of compounds for their physical dependence potential and abuse liability. IX. Drug Testing Program of the Committee on Problems of Drug Dependence, Inc. (1985). (3092095)
1986
46
Evidence for a drug dependence syndrome among narcotic users. (3463347)
1986
47
Role of conditioning factors in the development of drug dependence. (3534813)
1986
48
Drug dependence in pregnancy: intrapartum course and management. (3092082)
1986
49
Prescribing practices for pain in drug dependence: a lesson in ignorance. (2870625)
1985
50
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977

Variations for Drug Dependence

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Expression for genes affiliated with Drug Dependence

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Expression patterns in normal tissues for genes affiliated with Drug Dependence

Search GEO for disease gene expression data for Drug Dependence.

Pathways for genes affiliated with Drug Dependence

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Compounds for genes affiliated with Drug Dependence

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Compounds related to Drug Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1spiradoline449.8PDYN, OPRK1
2beta-endorphin289.7OPRD1, OPRK1
3[3h]diprenorphine289.7OPRD1, OPRK1
4beta-fna289.6OPRK1, OPRD1
5(-)-methadone289.6OPRD1, OPRK1
6(-)-pentazocine289.6OPRK1, OPRD1
7bntx289.6OPRK1, OPRD1
8etonitazene289.6OPRD1, OPRK1
9normorphine289.6OPRD1, OPRK1
10naltriben44 2810.6OPRD1, OPRK1
11(-)-quadazocine289.5OPRD1, OPRK1
12(-)-ekc289.5OPRD1, OPRK1
13beta funaltrexamine449.5OPRK1, OPRD1
14ici 174864449.4OPRK1, OPRD1
15morphinan449.4OPRD1, OPRK1
16bremazocine449.4OPRD1, OPRL1, OPRK1
17nalbzoh449.4OPRL1, OPRK1, OPRD1
18naltrexone44 28 50 1112.3OPRD1, OPRL1, OPRK1
19deltorphin449.3OPRK1, OPRD1
20(-)-bremazocine289.3OPRK1, OPRD1
21dermorphin449.3OPRK1, OPRD1, PDYN
22nalmefene44 2810.3PDYN, OPRD1, OPRK1
23norbinaltorphimine449.3PDYN, OPRK1, OPRD1
24pentazocine44 1110.3OPRD1, PDYN, OPRK1
25[3h]diprenorphine449.3OPRK1, PDYN, OPRD1
26dpdpe28 44 6111.3OPRD1, OPRK1, PDYN
27tetrapeptide449.3OPRD1, OPRL1, OPRK1
28methadone50 44 1111.3OPRK1, OPRD1, PDYN
29nor-binaltorphimine289.2OPRK1, OPRD1
30naloxone44 28 50 1112.2PDYN, OPRD1, OPRK1
31methamphetamine44 50 1111.2DRD3, OPRD1, PDYN
32dynorphin a-(1-13)289.0OPRK1, OPRD1
33damgo44 28 6111.0PDYN, OPRD1, OPRK1, OPRL1
34etorphine44 28 1111.0OPRK1, OPRL1, OPRD1, PDYN
35buprenorphine44 28 1110.9PDYN, OPRL1, OPRK1, OPRD1
36morphine44 50 28 1111.9OPRK1, OPRL1, PDYN, OPRD1
37amitriptyline44 28 50 1111.9CHRM2, OPRD1, OPRK1
38heroin44 50 1110.8PDYN, DRD3, OPRK1, OPRD1
39nmda44 289.7PDYN, OPRK1, OPRD1, DRD3
40gaba448.4CHRM2, PDYN, OPRD1, OPRK1
41clozapine44 28 50 1111.4OPRD1, OPRK1, DRD3, CHRM2
42acetylcholine44 50 28 24 1112.4OPRD1, PDYN, CHRM2, OPRK1
43cyclic amp44 249.0OPRL1, OPRK1, DRD3, OPRD1, CHRM2
44cocaine44 119.0OPRD1, OPRK1, PDYN, DRD3, CHRM2
45nicotine44 28 50 1111.0OPRK1, DRD3, PDYN, CHRM2, OPRD1
46potassium44 24 119.9OPRD1, DRD3, PDYN, CHRM2, OPRK1
47opiate447.6OPRD1, DRD3, CHRM2, PDYN, OPRK1, OPRL1
48norepinephrine44 24 119.6CHRM2, DRD3, OPRK1, OPRD1, PDYN, OPRL1
49gtp44 288.6CHRM2, PDYN, DRD3, OPRK1, OPRD1, OPRL1
50tyrosine447.2OPRK1, DRD3, OPRD1, OPRL1, PDYN, CHRM2

GO Terms for genes affiliated with Drug Dependence

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Cellular components related to Drug Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.6OPRK1, OPRL1, OPRD1, DRD3, CHRM2
2plasma membraneGO:0058866.4OPRK1, DARC, CHRM2, PDYN, DRD3, OPRD1

Biological processes related to Drug Dependence according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.8OPRK1, OPRL1
2behaviorGO:0076109.7OPRK1, OPRL1
3sensory perception of painGO:0192339.5OPRL1, OPRK1
4phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.4OPRK1, OPRD1
5neuropeptide signaling pathwayGO:0072189.4OPRD1, PDYN
6opioid receptor signaling pathwayGO:0380039.2OPRK1, OPRL1, OPRD1
7adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.2OPRD1, OPRL1, OPRK1
8locomotory behaviorGO:0076269.1OPRK1, DRD3
9G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.0OPRD1, CHRM2
10G-protein coupled receptor signaling pathwayGO:0071868.6CHRM2, DRD3, OPRD1

Molecular functions related to Drug Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1opioid receptor activityGO:0049859.3OPRK1, OPRD1

Products for genes affiliated with Drug Dependence

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  • Antibodies
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Sources for Drug Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet