MCID: DRG003
MIFTS: 57

Drug Dependence malady

Summaries for Drug Dependence

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A substance dependence that involves the continued use of drugs despite despite problems related to use of the substance.

MalaCards: Drug Dependence is related to alcohol dependence and substance dependence. An important gene associated with Drug Dependence is OPRL1 (opiate receptor-like 1), and among its related pathways are Dopamine receptors and Enzymatic degradation of dopamine by COMT. The compounds bremazocine and dermorphin have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related mouse phenotypes are adipose tissue and taste/olfaction.

Wikipedia:63 Substance dependence, commonly called drug addiction, is a compulsive need to use drugs in order to... more...

Aliases & Classifications for Drug Dependence

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

drug dependence 8 44 60


External Ids:

Disease Ontology8 DOID:9974
ICD9CM27 304.60, 304.6

Related Diseases for Drug Dependence

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17GeneCards, 18GeneDecks
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Diseases related to Drug Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1alcohol dependence31.3OPRM1, CHRM2, MAOA, CNR1, ADH1A, ADH4
2substance dependence30.6PDYN, DRD2, DRD3, OPRM1, CNR1, SLC6A3
3cocaine dependence30.5DRD3, OPRK1, OPRM1, SLC6A3, SLC6A4, DRD2
4personality disorder30.4DRD3, MAOA, SLC6A3, SLC6A4, DRD2
5nicotine dependence30.3SLC6A4, CHRNA2, DRD2
6opiate dependence30.3OPRM1
7morphine dependence30.3OPRK1, OPRD1
8conduct disorder30.3DRD2, MAOA, SLC6A3, SLC6A4
9heroin dependence30.0DRD2
10anxiety disorder30.0SLC6A4, MAOA
11borderline personality disorder30.0MAOA, SLC6A4
12social phobia30.0DRD2, SLC6A4, MAOA
13obesity30.0CNR1, SLC6A3, DRD2, MAOA
14alcohol abuse30.0OPRM1, DRD2, SLC6A4, SLC6A3, DRD3
15anorexia nervosa29.8SLC6A4, CNR1, MAOA
16cocaine abuse29.8SLC6A4, OPRK1, SLC6A3, DRD2
17antisocial personality disorder29.8DRD2, MAOA, SLC6A4, SLC6A3
18obsessive-compulsive disorder29.8DRD2, PDYN, MAOA, SLC6A4, SLC6A3, DRD3
19substance abuse29.8OPRM1, SLC6A3, SLC6A4, ADH4, CNR1, DRD2
20drug addiction29.8SLC6A3, DARC, OPRM1, OPRD1, OPRK1, DRD3
21schizophrenia29.8PNOC, SLC6A4, PDYN, DRD2, DRD3, OPRK1
22alzheimer's disease29.8MAOA, CNR1, SLC6A3, OPRM1, OPRD1, PDYN
23dependent personality disorder10.3
24barbiturate dependence10.1
25cerebritis10.1
26hepatitis10.1
27hepatitis c10.0
28neonatal abstinence syndrome10.0
29post-traumatic stress disorder10.0
30hallucinogen dependence10.0
31thrombocytopenia10.0
32major depressive disorder10.0CHRM2
33neuroblastoma10.0OPRM1
34restless legs syndrome10.0DRD2
35hypertension10.0SLC6A4
36bulimia nervosa10.0SLC6A4, MAOA
37fibromyalgia10.0SLC6A4, PNOC
38cluster headache10.0PNOC
39panic disorder10.0SLC6A4, MAOA
40hepatic encephalopathy10.0MAOA
41pathological gambling10.0DRD3, DRD2, SLC6A3
42delusional disorder10.0DRD2
43obsessive-compulsive personality disorder10.0SLC6A4
44multiple system atrophy10.0SLC6A3, DRD2
45constipation10.0OPRM1, SLC6A4
46withdrawal disorder10.0OPRM1, CNR1, PDYN
47alcoholic psychosis10.0SLC6A4
48chronic fatigue syndrome10.0MAOA, SLC6A4
49schizoaffective disorder10.0DRD2, SLC6A4, DRD3
50liver cirrhosis10.0PNOC, CNR1

Graphical network of the top 20 diseases related to Drug Dependence:



Diseases related to drug dependence

Clinical Features for Drug Dependence

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Drugs & Therapeutics for Drug Dependence

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Drug Dependence

Drug clinical trials:

Search ClinicalTrials for Drug Dependence

Search NIH Clinical Center for Drug Dependence

Search CenterWatch for Drug Dependence

Genetic Tests for Drug Dependence

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Anatomical Context for Drug Dependence

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32MalaCards
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MalaCards organs/tissues related to Drug Dependence:

32
Brain, Testes, Breast, Prostate, Colon, Myeloid, Lung, Bone marrow, T cells, Smooth muscle, Liver, Bone, Cortex, Prefrontal cortex

Animal Models for Drug Dependence or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Drug Dependence:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2CNR1, OPRM1, DRD3, DRD2, PDYN
2MP:00053949.9DRD2, CNR1, SLC6A3, ADH7
3MP:00107719.9PDYN, DRD2, OPRK1, OPRD1, OPRL1, OPRM1
4MP:00053869.7ADH7, PDYN, DRD2, DRD3, OPRK1, OPRD1
5MP:00053769.6OPRM1, OPRL1, OPRD1, DRD3, DRD2, PDYN
6MP:00036319.5PDYN, DRD2, DRD3, OPRD1, OPRL1, OPRM1

Publications for Drug Dependence

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Sources:
50PubMed
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Articles related to Drug Dependence:

(show top 50)    (show all 782)
idTitleAuthorsYear
1
Do Tobacco Smoking and Illicit Drug/Alcohol Dependence Increase the Risk of Mental Disorders Among Men? Evidence from a National Urban Bangladeshi Sample. (24433484)
2014
2
A possible case of natalizumab-dependent suicide attempt: A brief review about drugs and suicide. (24347991)
2013
3
Methylphenidate for attention deficit hyperactivity disorder and drug relapse in criminal offenders with substance dependence: a 24-week randomized placebo-controlled trial. (24118269)
2013
4
The mountain roared and brought forth a mouse*: comments on the results of an expert panel on standardization of drug dependence treatment trial outcome variables. (22372700)
2012
5
Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals. (22211341)
2012
6
Genetic etiology of the common liability to drug dependence: evidence of common and specific mechanisms for DSM-IV dependence symptoms. (22243758)
2012
7
More mice or a better mouse trap? Reflections on primary outcome indices in illicit drug dependence treatment research. (22372701)
2012
8
Heroin dependence and bloodborne virus transmission behaviors for HIV infection among newly incarcerated injection drug users in Taiwan. (20964533)
2011
9
Identification of selective agonists and antagonists to g protein-activated inwardly rectifying potassium channels: candidate medicines for drug dependence and pain. (21886574)
2011
10
Implications of drug dependence on dental patient management. (20478804)
2010
11
Establishment of a multiplex ligation-dependent SNP genotyping method and its application in the detection of genes related to chemotherapeutic drugs in breast cancer]. (19538885)
2009
12
The Mountain Council on Alcohol and Drug Dependence. (19534066)
2009
13
Influence of depression and early adverse experiences on illicit drug dependence: a case-control study. (19578681)
2009
14
Does the 'gateway' matter? Associations between the order of drug use initiation and the development of drug dependence in the National Comorbidity Study Replication. (18466664)
2009
15
Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors. (20230764)
2009
16
Raft-dependent endocytosis of autocrine motility factor/phosphoglucose isomerase: a potential drug delivery route for tumor cells. (18974847)
2008
17
Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine. (18991953)
2008
18
Applying drug dependence research to prevention interventions in Spain. (18349352)
2008
19
A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. (17202550)
2007
20
Heroin and cocaine dependence and the risk of accidental non-fatal drug overdose. (16956872)
2006
21
Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. (16452230)
2006
22
The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: time- and p53 expression-dependency of anti-cancer drugs. (16077963)
2005
23
Patterns of DSM-IV alcohol abuse and dependence criteria among adolescents and adults: results from the 2001 National Household Survey on Drug Abuse. (15897727)
2005
24
Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs. (15836613)
2005
25
Effects of borderline personality disorder features and a family history of alcohol or drug dependence on P300 in adolescents. (15172136)
2004
26
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis. (12861054)
2003
27
Development of vaccines to help treat drug dependence. (12669472)
2003
28
Quetiapine in the successful treatment of schizophrenia with comorbid alcohol and drug dependence: a case report. (12906345)
2003
29
Species-dependency in chiral-drug recognition of serum albumin studied by chromatographic methods. (12543492)
2002
30
Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance. (12487151)
2002
31
PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. (11803475)
2002
32
Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence. (11276551)
2001
33
Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs. (11064187)
2000
34
Dialectical behavior therapy for patients with borderline personality disorder and drug-dependence. (10598211)
1999
35
Impulsivity and history of drug dependence. (9649965)
1998
36
College on problems of drug dependence presidential address 1996: inhalant abuse, a forgotten drug abuse problem. (9188104)
1997
37
An adoption study of DSM-IIIR alcohol and drug dependence severity. (8793305)
1996
38
Introduction to the role of excitatory amino acids in the actions of abused drugs: a symposium presented at the 1993 annual meeting of the College on Problems of Drug Dependence. (7758407)
1995
39
Expression of the multiple drug resistance gene in human renal cell carcinoma depends on tumor histology, grade, and stage. (9815963)
1995
40
A summary of recommendations for the management of opioid dependence: the quality assurance in the treatment of drug dependence project. (16818344)
1994
41
Clinical freedom and drug dependence. No rationale for prescribing cocaine to addicts. (8123150)
1993
42
Conditioning mechanisms in drug dependence. (1498991)
1992
43
Factors in mortality by drug dependence among Puerto Ricans in New York City. (2330939)
1990
44
New mandatory course in alcohol and drug dependence for medical students at the Karolinska Institute. (2711914)
1989
45
The diagnosis of alcohol, cocaine, and other drug dependence in an inpatient treatment population. (2709471)
1989
46
Progress in understanding the conditioning aspects of drug dependence. (3136377)
1988
47
Munchausen's syndrome and drug dependence. (3814959)
1986
48
Postgraduate certification in alcohol and drug dependence. (3904501)
1985
49
Effect of cholinergic drugs on acute and chronic morphine dependence. (7202346)
1982
50
Notes on Alcoholism and Drug Abuse: Propoxyphene-Napsylate (Darvon-N or PN) in the Treatment of Heroin Dependence. (18747998)
1977

Genetic Variations for Drug Dependence

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Expression for genes affiliated with Drug Dependence

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Drug Dependence

Search GEO for disease gene expression data for Drug Dependence.

Pathways for genes affiliated with Drug Dependence

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 49PharmGKB
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Pathways related to Drug Dependence according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4DRD3, DRD2
2
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10.3SLC6A3, MAOA
3
Hide members
10.3ADH6, ADH4
410.3DRD3, CHRM2, DARC
5
Hide members
10.2PDYN, MAOA, SLC6A3, DRD2
610.2SLC6A3, PDYN, DRD2, MAOA
7
Hide members
10.2DARC, OPRM1, OPRL1, OPRD1, OPRK1
8
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10.2SLC6A4, MAOA, CHRM2, DRD3, DRD2
9
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10.1ADH4, ADH7, ADH6, ADH1A
10
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10.1ADH1A, ADH6, ADH7, ADH4
11
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10.1ADH1A, ADH4, ADH6, ADH7
12
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10.1ADH7, ADH4, ADH1A, ADH6
13
Hide members
10.1ADH1A, ADH6, ADH7, ADH4
1410.1ADH1A, ADH7, ADH4, ADH6, MAOA
15
Hide members
10.1ADH7, MAOA, ADH1A, ADH4, ADH6
16
Hide members
10.0OPRM1, CHRM2, MAOA, CNR1, SLC6A3, SLC6A4
17
Hide members
9.8OPRD1, PNOC, OPRK1, DARC, CNR1, DRD3
18
Hide members
9.7DRD2, OPRK1, CNR1, PDYN, DRD3, DARC

Compounds for genes affiliated with Drug Dependence

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Drug Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 286)
idCompoundScoreTop Affiliating Genes
1bremazocine4410.6OPRK1, OPRM1, OPRL1, OPRD1
2dermorphin4410.6PDYN, OPRM1, OPRD1, OPRK1
3nalbzoh4410.6OPRD1, OPRM1, OPRK1, OPRL1, PNOC
4nalmefene44 2811.6OPRM1, OPRD1, OPRK1, PDYN
5norbinaltorphimine4410.6OPRD1, PNOC, OPRK1, OPRM1, PDYN
6[3h]diprenorphine4410.6OPRD1, OPRM1, PDYN, PNOC, OPRK1
7dpdpe28 44 5912.6OPRM1, OPRK1, OPRD1, PNOC, PDYN
8naltrindole44 2811.6PNOC, OPRM1, OPRD1, OPRK1
9damgo44 59 2812.5OPRL1, PDYN, PNOC, OPRK1, OPRD1, OPRM1
10etorphine44 28 1112.5PNOC, OPRK1, OPRL1, OPRD1, PDYN, OPRM1
11pentazocine44 1111.5OPRM1, OPRK1, PDYN, OPRD1
12buprenorphine44 28 1112.5OPRL1, OPRM1, PNOC, PDYN, OPRK1, OPRD1
13baclofen44 1111.5PNOC, CNR1, SLC6A3, OPRD1, OPRM1
14quinpirole44 2811.5DRD3, DRD2, PDYN, SLC6A3, CNR1
15sufentanil44 1111.5OPRM1, OPRD1, OPRK1, PNOC
16naltrexone44 49 28 1113.5OPRM1, OPRL1, PNOC, OPRD1, OPRK1
17naloxone44 49 28 1113.5OPRM1, CNR1, OPRD1, OPRK1, PNOC, PDYN
18amitriptyline44 49 28 1113.5SLC6A4, SLC6A3, CHRM2, OPRD1, MAOA, OPRK1
196-hydroxydopamine4410.5DRD2, DRD3, OPRM1, MAOA, SLC6A3, PDYN
20tyramine44 28 2412.4OPRD1, SLC6A4, OPRM1, MAOA, SLC6A3
21capsaicin44 2811.4PDYN, OPRK1, OPRM1, OPRD1, PNOC, MAOA
22methadone44 49 1112.4PDYN, DRD2, OPRK1, OPRD1, OPRM1
23clozapine44 28 49 1113.4DRD2, DRD3, OPRK1, OPRD1, CHRM2, SLC6A3
24methamphetamine44 49 1112.4DRD2, PDYN, DRD3, OPRD1, OPRM1, MAOA
25nmda44 2811.4OPRD1, OPRK1, PDYN, OPRM1, MAOA, SLC6A3
26amphetamine44 1111.4SLC6A4, CNR1, MAOA, OPRK1, DRD2, PDYN
27indole4410.4OPRD1, SLC6A4, PNOC, MAOA, OPRK1
28levodopa44 1111.4OPRM1, DRD3, MAOA, CNR1, SLC6A3, PDYN
29d amphetamine4410.4SLC6A3, MAOA, DRD2, SLC6A4
30Tapentadol1110.4OPRM1, SLC6A4, OPRD1, OPRK1
31bupropion44 49 11 2413.4SLC6A4, DRD2, CNR1, SLC6A3, DRD3
32heroin44 49 1112.4PDYN, DRD2, DRD3, OPRK1, OPRD1, OPRM1
33morphine44 49 28 1113.4PDYN, DRD2, OPRL1, OPRM1, CNR1, PNOC
34paroxetine44 49 28 1113.3DRD3, SLC6A4, SLC6A3, MAOA, CHRM2
35acetylcholine44 49 28 11 2414.3PDYN, PNOC, SLC6A3, CNR1, OPRM1, OPRD1
36tramadol44 49 1112.3OPRD1, OPRK1, OPRM1, SLC6A4
375-hydroxytryptamine4410.3SLC6A3, PNOC, CNR1, MAOA, CHRM2, OPRL1
38choline44 11 2412.2CHRM2, ADH6, SLC6A3, SLC6A4, ADH1A, MAOA
39opiate4410.2OPRD1, OPRL1, OPRM1, CHRM2, PNOC, DRD3
40cocaine44 1111.2PDYN, DRD2, DRD3, OPRK1, OPRD1, OPRM1
41gaba4410.2SLC6A4, SLC6A3, PNOC, CNR1, MAOA, CHRM2
42dopamine44 28 11 2413.2SLC6A4, PNOC, CNR1, MAOA, OPRD1, OPRK1
43glutamate4410.1DRD3, SLC6A4, SLC6A3, PNOC, CNR1, PDYN
44desipramine44 49 1112.1CHRM2, SLC6A4, MAOA, CNR1, SLC6A3
45mptp4410.1DRD2, DRD3, MAOA, SLC6A3, SLC6A4
46nicotine44 49 28 1113.1SLC6A4, SLC6A3, CNR1, MAOA, CHRM2, CHRNA2
47gtp44 2811.1DRD3, OPRK1, PNOC, CHRM2, OPRM1, OPRL1
48norepinephrine44 11 2412.1PDYN, SLC6A4, SLC6A3, PNOC, CNR1, MAOA
49fluoxetine49 44 28 1113.0SLC6A4, SLC6A3, CNR1, DRD2, MAOA
50piperazine44 1110.9DRD3, DRD2, OPRM1, SLC6A3

GO Terms for genes affiliated with Drug Dependence

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Sources:
16Gene Ontology
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Cellular components related to Drug Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.7PDYN, DRD2, DRD3, SLC6A3, DARC, CNR1
2integral to plasma membraneGO:0058879.6DRD2, SLC6A4, SLC6A3, CNR1, CHRM2, OPRM1

Biological processes related to Drug Dependence according to GeneCards/GeneDecks:

(show all 45)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
2response to histamineGO:03477610.7DRD2, DRD3
3regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD2, DRD3
4opioid receptor signaling pathwayGO:03800310.7OPRK1, OPRD1
5adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.7DRD3, DRD2
6dopamine catabolic processGO:04242010.7MAOA, SLC6A3
7regulation of cAMP metabolic processGO:03081410.7DRD3, DRD2
8response to morphineGO:04327810.7CNR1, DRD3, DRD2
9prepulse inhibitionGO:06013410.7SLC6A3, DRD3, DRD2
10negative regulation of blood pressureGO:04577610.7CNR1, DRD3, DRD2
11negative regulation of adenylate cyclase activityGO:00719410.7OPRM1, DRD3, DRD2
12response to nicotineGO:03509410.7DRD2, CNR1, SLC6A3
13phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00720010.7OPRM1, OPRD1, OPRK1
14monoamine transportGO:01584410.7SLC6A3, SLC6A4
15adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.7OPRM1, OPRL1, OPRD1, OPRK1
16adenohypophysis developmentGO:02198410.7SLC6A3, DRD2
17reduction of cytosolic calcium ion concentrationGO:05148110.7OPRM1, DRD2
18sensory perceptionGO:00760010.7PNOC, OPRM1, OPRL1, OPRK1
19sensory perception of painGO:01923310.7OPRK1, OPRM1, CNR1
20behavioral response to ethanolGO:04814910.7DRD2, OPRM1
21response to cocaineGO:04222010.7DRD2, DRD3, CNR1, SLC6A3
22behaviorGO:00761010.7OPRK1, OPRM1, MAOA, CNR1
23regulation of synaptic transmission, GABAergicGO:03222810.7DRD2, CNR1
24G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7OPRD1, OPRM1, CHRM2, CNR1
25alcohol metabolic processGO:00606610.6ADH1A, ADH4
26dopamine metabolic processGO:04241710.6DRD2, DRD3
27regulation of dopamine secretionGO:01405910.6DRD2, DRD3
28adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.6DRD3, OPRM1
29negative regulation of protein secretionGO:05070910.6DRD2, DRD3
30locomotory behaviorGO:00762610.6SLC6A3, OPRM1, OPRK1, DRD3, DRD2
31behavioral response to cocaineGO:04814810.6DRD2, DRD3
32ethanol oxidationGO:00606910.6ADH1A, ADH4, ADH6, ADH7
33response to iron ionGO:01003910.6DRD2, SLC6A3
34G-protein coupled receptor internalizationGO:00203110.6DRD2, DRD3
35response to ethanolGO:04547110.6ADH7, ADH6, SLC6A3, CNR1, DRD3
36synaptic transmission, dopaminergicGO:00196310.5DRD2, DRD3
37xenobiotic metabolic processGO:00680510.5MAOA, ADH1A, ADH4, ADH6, ADH7
38synaptic transmissionGO:00726810.5PDYN, OPRK1, CHRNA2, MAOA, PNOC, SLC6A3
39arachidonic acid secretionGO:05048210.4DRD2, DRD3
40neuropeptide signaling pathwayGO:00721810.4PNOC, OPRD1, PDYN
41response to drugGO:04249310.4DRD2, DRD3, SLC6A3, SLC6A4
42positive regulation of renal sodium excretionGO:03581510.4DRD2, DRD3
43retinol metabolic processGO:04257210.3ADH7, ADH4
44circadian regulation of gene expressionGO:03292210.3DRD2, DRD3
45neurotransmitter biosynthetic processGO:04213610.0SLC6A3, MAOA

Molecular functions related to Drug Dependence according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.4SLC6A3, DRD3, DRD2
2dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.4DRD3, DRD2
3alcohol dehydrogenase activity, zinc-dependentGO:00402410.4ADH1A, ADH4, ADH7
4alcohol dehydrogenase (NAD) activityGO:00402210.3ADH7, ADH6, ADH4, ADH1A
5drug bindingGO:00814410.3DRD2, DRD3, CNR1, SLC6A3
6monoamine transmembrane transporter activityGO:00850410.3SLC6A3, SLC6A4
7retinol dehydrogenase activityGO:00474510.3ADH7, ADH4
8opioid peptide activityGO:00151510.2PDYN, PNOC
9retinol bindingGO:01984110.0ADH7, ADH4

Products for genes affiliated with Drug Dependence

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Sources for Drug Dependence

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet