MCID: DRG003
MIFTS: 49

Drug Dependence malady

Mental diseases category
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Summaries for Drug Dependence

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A substance dependence that involves the continued use of drugs despite despite problems related to use of the substance.

MalaCards: Drug Dependence is related to substance dependence and alcohol dependence. An important gene associated with Drug Dependence is OPRL1 (opiate receptor-like 1), and among its related pathways are Monoamine GPCRs and GPCRs, Other. The compounds spiradoline and beta-endorphin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and cortex, and related mouse phenotypes are nervous system and integument.

Wikipedia:65 Substance dependence, commonly called drug addiction, is a compulsive need to use drugs in order to... more...

Aliases & Classifications for Drug Dependence

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8Disease Ontology, 45Novoseek, 62UMLS, 27ICD9CM, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

drug dependence 8 45 62


External Ids:

Disease Ontology8 DOID:9974
ICD9CM27 304.60, 304.6

Related Diseases for Drug Dependence

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Drug Dependence via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1substance dependence30.5PDYN, DRD3
2alcohol dependence30.4OPRK1, OPRD1, CHRM2
3opiate dependence30.2OPRK1, PDYN, DRD3, OPRD1
4cocaine dependence30.1PDYN, DRD3, OPRK1
5obsessive-compulsive disorder29.9PDYN, DRD3
6schizophrenia29.7CHRM2, PDYN, DRD3, OPRK1
7drug addiction29.7OPRK1, OPRD1, PDYN, DRD3, DARC
8alzheimer's disease29.6CHRM2, OPRK1, OPRD1, DRD3, PDYN
9personality disorder10.3
10chronic pain10.2
11conduct disorder10.2
12heroin dependence10.2
13cerebritis10.2
14hepatitis10.2
15headache10.2
16hepatitis c10.1
17borderline personality disorder10.1
18neonatal abstinence syndrome10.1
19post-traumatic stress disorder10.1
20social phobia10.1
21anxiety disorder10.1
22obesity10.1
23thrombocytopenia10.1
24hiv-110.1
25psychotic disorder10.0DRD3, PDYN
26mood disorder10.0DRD3, PDYN
27encephalitis10.0PDYN, DARC
28morphine dependence10.0OPRD1, OPRK1
29parkinson's disease10.0PDYN, DRD3
30pain agnosia10.0OPRK1, OPRL1, PDYN
31congestive heart failure10.0PDYN, CHRM2
32migraine10.0DRD3, CHRM2
33bipolar disorder10.0PDYN, DRD3, OPRK1
34amnestic disorder10.0OPRD1, OPRK1, PDYN
35ipex syndrome10.0DARC, OPRK1, PDYN
36cannabis dependence9.9
37barbiturate dependence9.9
38antisocial personality disorder9.9
39bernard-soulier syndrome9.9
40neuronitis9.9
41acquired immunodeficiency syndrome9.9
42hepatitis d9.9
43placental abruption9.9
44cocaine abuse9.9
45anorexia nervosa9.9
46asthma9.9
47hallucinogen dependence9.9
48malaria9.9
49prostate cancer9.9
50prostatitis9.9

Graphical network of the top 20 diseases related to Drug Dependence:



Diseases related to drug dependence

Symptoms for Drug Dependence

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Drugs & Therapeutics for Drug Dependence

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Drug Dependence

Search NIH Clinical Center for Drug Dependence

Genetic Tests for Drug Dependence

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Anatomical Context for Drug Dependence

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33MalaCards
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MalaCards organs/tissues related to Drug Dependence:

33
Testes, Brain, Cortex, Breast, Prostate, Prefrontal cortex

Animal Models for Drug Dependence or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Drug Dependence:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.7OPRL1, OPRD1, DRD3, PDYN, CHRM2
2MP:00107717.6CHRM2, PDYN, OPRD1, OPRL1, OPRK1
3MP:00053867.2OPRK1, OPRL1, OPRD1, DRD3, PDYN, CHRM2
4MP:00053767.0DARC, CHRM2, PDYN, DRD3, OPRD1, OPRL1

Publications for Drug Dependence

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Sources:
52PubMed
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Articles related to Drug Dependence:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Is there a family profile of addictive behaviors? Family functioning in anorexia nervosa and drug dependence disorder. (23794317)
2014
2
The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence. (24189487)
2014
3
Problematic alcohol use in clients recovering from drug dependence--time to adjust our focus. (23668295)
2013
4
Child neglect and the development of externalizing behavior problems: associations with maternal drug dependence and neighborhood crime. (23136210)
2013
5
Resting state synchrony in long-term abstinent alcoholics with versus without comorbid drug dependence. (23639390)
2013
6
Neurobiological correlates of the familial risk for stimulant drug dependence. (23147481)
2013
7
Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience. (23523373)
2013
8
Drug-dependent at birth: neonatal abstinence syndrome in Tennessee. (23544286)
2013
9
The influence of gene-environment interactions on the development of alcoholism and drug dependence. (22367454)
2012
10
An analysis of abstracts presented to the college on problems of drug dependence meeting and subsequent publication in peer review journals. (19889211)
2009
11
The Mountain Council on Alcohol and Drug Dependence. (19534066)
2009
12
Endogenous modulators for drug dependence. (18758051)
2008
13
Drug-dependent boys are more depressed compared to girls: a comorbidity study of substance dependence and mental disorders. (18552492)
2008
14
The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-alpha, and an inducer of these factors in drug dependence. (17538232)
2007
15
The relationship between legal status, perceived pressure and motivation in treatment for drug dependence: results from a European study of Quasi-Compulsory Treatment. (16968995)
2006
16
Lifetime illicit drug use and drug dependence are common by the age of 25 in New Zealand. (16868205)
2006
17
Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. (16622805)
2006
18
Individual differences in drug dependence in rats: the role of genetic factors and life events. (16253227)
2005
19
Treatment of chronic hepatitis C in patients with drug dependence: time to change the rules? (15317637)
2004
20
Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence. (11526463)
2001
21
Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence. (11276551)
2001
22
College on Problems of Drug Dependence. 62nd Annual Scientific Meeting. June 17-22, 2000. San Juan, Puerto Rico. Abstracts. (11252251)
2000
23
Drug dependence in a journal club. (10833978)
2000
24
Problems of drug dependence 1999: Proceedings of the 61st annual scientific meeting, the College on Problems of Drug Dependence, Inc. (11680410)
1999
25
Childhood stress and symptoms of drug dependence in adolescence and early adulthood: social phobia as a mediator. (9990437)
1999
26
Drug dependence scale in the Millon Clinical Multiaxial inventory. (9178439)
1997
27
Elementary particles for models of drug dependence, 10th Okey Memorial Lecture presented at the Institute of Psychiatry, London on 19th March 1997. (9449017)
1997
28
Statement on national drug policy. College on problems of drug dependence. (9279499)
1997
29
College on Problems of Drug Dependence policy on administering drugs with abuse potential in human research. (11654740)
1996
30
Prevalence and correlates of drug use and DSM-IV drug dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. (8880660)
1996
31
Contract program for veterans with alcohol and drug dependence disorders--VA. Final rule. (10172801)
1996
32
Effects of psychiatric care for dual diagnosis patients treated in a drug dependence clinic. (7484981)
1995
33
Prescription drug dependence in the elderly population: demographic and clinical features of 100 inpatients. (7967773)
1994
34
Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. (8018097)
1994
35
Neurochemistry of Drug Dependence. Proceedings of Biochemical Society Symposium No. 59. London, December 1992. (7910737)
1993
36
Components of drug dependence: reinforcement, discrimination and adaptation. (8192682)
1993
37
Drug dependence in prisoners. (2025727)
1991
38
Drug dependence and pregnancy: antenatal and intrapartum problems. (2221329)
1990
39
Brief history of control, prevention and treatment of drug dependence in Japan. (2183987)
1990
40
Towards freedom: treatment approaches to drug dependence at TTK Hospital. (2611423)
1989
41
The therapeutic community model in the treatment of drug dependence: its advantages and disadvantages. (2509837)
1989
42
Problems of drug dependence, 1988. Proceedings of the 50th annual scientific meeting, the Committee on Problems of Drug Dependence, Inc. North Falmouth, Massachusetts, June 1988. (3151918)
1988
43
Alcohol and other drug dependence among latinos. (18750251)
1987
44
Biological evaluation of compounds for their physical dependence potential and abuse liability. IX. Drug Testing Program of the Committee on Problems of Drug Dependence, Inc. (1985). (3092095)
1986
45
Evidence for a drug dependence syndrome among narcotic users. (3463347)
1986
46
Role of conditioning factors in the development of drug dependence. (3534813)
1986
47
Drug dependence in pregnancy: intrapartum course and management. (3092082)
1986
48
Educational philosophy and practice: contributors to alcohol and drug dependence in Australia? (3733099)
1986
49
Prescribing practices for pain in drug dependence: a lesson in ignorance. (2870625)
1985
50
Quinidine leukopenia and thrombocytopenia with a drug-dependent leukoagglutinin. (836544)
1977

Variations for Drug Dependence

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Expression for genes affiliated with Drug Dependence

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Drug Dependence

Search GEO for disease gene expression data for Drug Dependence.

Pathways for genes affiliated with Drug Dependence

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 12EMD Millipore, 30KEGG
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Compounds for genes affiliated with Drug Dependence

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB
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Compounds related to Drug Dependence according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1spiradoline459.8PDYN, OPRK1
2beta-endorphin299.7OPRD1, OPRK1
3[3h]diprenorphine299.7OPRD1, OPRK1
4beta-fna299.6OPRK1, OPRD1
5(-)-methadone299.6OPRD1, OPRK1
6(-)-pentazocine299.6OPRK1, OPRD1
7bntx299.6OPRK1, OPRD1
8etonitazene299.6OPRD1, OPRK1
9normorphine299.6OPRD1, OPRK1
10naltriben45 2910.6OPRD1, OPRK1
11(-)-quadazocine299.5OPRD1, OPRK1
12(-)-ekc299.5OPRD1, OPRK1
13beta funaltrexamine459.5OPRK1, OPRD1
14ici 174864459.4OPRK1, OPRD1
15morphinan459.4OPRD1, OPRK1
16bremazocine459.4OPRD1, OPRL1, OPRK1
17nalbzoh459.4OPRL1, OPRK1, OPRD1
18naltrexone45 29 51 1112.3OPRD1, OPRL1, OPRK1
19deltorphin459.3OPRK1, OPRD1
20(-)-bremazocine299.3OPRK1, OPRD1
21dermorphin459.3OPRK1, OPRD1, PDYN
22nalmefene45 2910.3PDYN, OPRD1, OPRK1
23norbinaltorphimine459.3PDYN, OPRK1, OPRD1
24pentazocine45 1110.3OPRD1, PDYN, OPRK1
25[3h]diprenorphine459.3OPRK1, PDYN, OPRD1
26dpdpe29 45 6111.3OPRD1, OPRK1, PDYN
27tetrapeptide459.3OPRD1, OPRL1, OPRK1
28methadone51 45 1111.3OPRK1, OPRD1, PDYN
29nor-binaltorphimine299.2OPRK1, OPRD1
30naloxone45 29 51 1112.2PDYN, OPRD1, OPRK1
31methamphetamine45 51 1111.2DRD3, OPRD1, PDYN
32dynorphin a-(1-13)299.0OPRK1, OPRD1
33damgo45 29 6111.0PDYN, OPRD1, OPRK1, OPRL1
34etorphine45 29 1111.0OPRK1, OPRL1, OPRD1, PDYN
35buprenorphine45 29 1110.9PDYN, OPRL1, OPRK1, OPRD1
36morphine45 51 29 1111.9OPRK1, OPRL1, PDYN, OPRD1
37amitriptyline45 29 51 1111.9CHRM2, OPRD1, OPRK1
38heroin45 51 1110.8PDYN, DRD3, OPRK1, OPRD1
39nmda45 299.7PDYN, OPRK1, OPRD1, DRD3
40gaba458.4CHRM2, PDYN, OPRD1, OPRK1
41clozapine45 29 51 1111.4OPRD1, OPRK1, DRD3, CHRM2
42acetylcholine45 51 29 24 1112.4OPRD1, PDYN, CHRM2, OPRK1
43cyclic amp45 249.0OPRL1, OPRK1, DRD3, OPRD1, CHRM2
44cocaine45 119.0OPRD1, OPRK1, PDYN, DRD3, CHRM2
45nicotine45 29 51 1111.0OPRK1, DRD3, PDYN, CHRM2, OPRD1
46potassium45 24 119.9OPRD1, DRD3, PDYN, CHRM2, OPRK1
47opiate457.6OPRD1, DRD3, CHRM2, PDYN, OPRK1, OPRL1
48norepinephrine45 24 119.6CHRM2, DRD3, OPRK1, OPRD1, PDYN, OPRL1
49gtp45 298.6CHRM2, PDYN, DRD3, OPRK1, OPRD1, OPRL1
50tyrosine457.2OPRK1, DRD3, OPRD1, OPRL1, PDYN, CHRM2

GO Terms for genes affiliated with Drug Dependence

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16Gene Ontology
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Cellular components related to Drug Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058877.6OPRK1, OPRL1, OPRD1, DRD3, CHRM2
2plasma membraneGO:0058866.4OPRK1, DARC, CHRM2, PDYN, DRD3, OPRD1

Biological processes related to Drug Dependence according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sensory perceptionGO:0076009.8OPRK1, OPRL1
2behaviorGO:0076109.7OPRK1, OPRL1
3sensory perception of painGO:0192339.5OPRL1, OPRK1
4phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.4OPRK1, OPRD1
5neuropeptide signaling pathwayGO:0072189.4OPRD1, PDYN
6opioid receptor signaling pathwayGO:0380039.2OPRK1, OPRL1, OPRD1
7adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.2OPRD1, OPRL1, OPRK1
8locomotory behaviorGO:0076269.1OPRK1, DRD3
9G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.0OPRD1, CHRM2
10G-protein coupled receptor signaling pathwayGO:0071868.6CHRM2, DRD3, OPRD1

Molecular functions related to Drug Dependence according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1opioid receptor activityGO:0049859.3OPRK1, OPRD1

Products for genes affiliated with Drug Dependence

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  • Antibodies
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Sources for Drug Dependence

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet