MCID: DRG002
MIFTS: 51

Drug-Induced Hepatitis malady

Gastrointestinal diseases category

Summaries for Drug-Induced Hepatitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. more...

MalaCards: Drug-Induced Hepatitis, also known as hepatitis, chronic, drug-induced, is related to hepatitis and tuberculosis. An important gene associated with Drug-Induced Hepatitis is UGT1A3 (UDP glucuronosyltransferase 1 family, polypeptide A3), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Carbamazepine Pathway, Pharmacokinetics. The compounds thiopurine and flunitrazepam have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and t cells, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Drug-Induced Hepatitis

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9Disease Ontology, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

drug-induced hepatitis 9
hepatitis, chronic, drug-induced 63
drug-induced chronic hepatitis 9
hepatitis, drug-induced 63


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Disease Ontology9 DOID:2044
SNOMED-CT59 235889003
MeSH36 D056487

Related Diseases for Drug-Induced Hepatitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Drug-Induced Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.6SLC17A5, GPT
2tuberculosis30.8CYP2E1, TNF, NAT2, ALB
3autoimmune hepatitis30.0UGT1A1, CYP2D6, CYP2C9, GPT, GSTT1, SLC17A5
4pulmonary tuberculosis10.2
5hepatitis a10.2
6crigler-najjar syndrome10.1UGT1A1
7gilbert syndrome10.1UGT1A1, NAT2
8brain cancer10.1GSTM1, GSTT1
9asbestosis10.1GSTM1, GSTT1
10neuroleptic malignant syndrome10.1CYP2D6
11fatty liver disease10.1CYP2E1, SLC17A5
12fascioliasis10.1SORD, SLC17A5
13hyperinsulinism10.1
14dystonia10.1
15melanoma10.1
16meningitis10.1
17multiple myeloma10.1
18myeloma10.1
19psoriasis10.1
20bladder carcinoma in situ10.1NAT2, NAT1, GSTM1
21choledocholithiasis10.1GPT, SLC17A5
22pancreatitis, chronic10.1UGT1A1, CYP2E1, GSTT1
23alcoholic hepatitis10.1CYP2E1, TNF
24open-angle glaucoma10.1GSTT1, GSTM1
25pyridoxine deficiency10.1GPT, SLC17A5
26aplastic anemia10.1CYP2D6, GSTM1, GSTT1
27diabetic cataract10.1SORD, CAT
28nasopharynx carcinoma10.1CYP2E1, NAT2, GSTM1, GSTT1
29bladder carcinoma10.1NAT2, NAT1, GSTM1, GSTT1
30endometriosis10.1NAT2, GSTM1, GSTT1
31acute lymphoblastic leukemia, childhood10.1CYP2E1, NAT1, GSTM1, GSTT1
32hepatorenal syndrome10.1ALB
33acute myeloid leukemia, adult10.1GSTM1, GSTT1
34obstructive jaundice10.1GPT, SLC17A5
35transitional cell carcinoma10.0NAT2, NAT1, GSTM1, GSTT1
36gastric adenocarcinoma10.0NAT2, NAT1, GSTM1, GSTT1
37basal cell carcinoma10.0GSTT1, GSTM1, CYP2D6
38senile cataract10.0CAT, GSTM1, GSTT1
39alcohol abuse10.0CYP2E1, GPT, SLC17A5
40hellp syndrome10.0SLC17A5, GPT
41cholelithiasis10.0GPT, UGT1A1
42scrub typhus10.0SLC17A5, GPT
43non-hodgkin lymphoma10.0CYP2E1, NAT2, NAT1, GSTM1, GSTT1
44periodontal disease10.0TNF, NAT2, SLC17A5
45kernicterus10.0UGT1A1, ALB
46bilirubin metabolic disorder10.0UGT1A3, UGT1A1, ALB
47oral cancer10.0CYP2E1, CAT, GSTM1, GSTT1
48schizophrenia10.0GLUD1, CYP2C9, CYP2D6, CYP2C19
49laryngeal squamous cell carcinoma10.0CYP2D6, CYP2E1, NAT2, GSTM1, GSTT1
50epilepsy syndrome10.0GLUD1, CYP2C9, CYP2D6, CYP2C19

Graphical network of the top 20 diseases related to Drug-Induced Hepatitis:



Diseases related to drug-induced hepatitis

Symptoms for Drug-Induced Hepatitis

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Drugs & Therapeutics for Drug-Induced Hepatitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Drug-Induced Hepatitis

Drug clinical trials:

Search ClinicalTrials for Drug-Induced Hepatitis

Search NIH Clinical Center for Drug-Induced Hepatitis

Search CenterWatch for Drug-Induced Hepatitis

Genetic Tests for Drug-Induced Hepatitis

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Anatomical Context for Drug-Induced Hepatitis

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Drug-Induced Hepatitis:

34
Liver, Testes, T cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Drug-Induced Hepatitis:
id TissueAnatomical CompartmentCell Relevance
1 LiverLiver LobuleHepatocytes Affected by disease

Animal Models for Drug-Induced Hepatitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Drug-Induced Hepatitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053765.7SLC17A5, TNF, SORD, NAT2, NAT1, GHR

Publications for Drug-Induced Hepatitis

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Sources:
53PubMed
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Articles related to Drug-Induced Hepatitis:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
A rare coexistence: drug induced hepatitis and meningitis in association with Ibuprofen. (23671551)
2013
2
Cytochrome P450 2E1 gene polymorphisms/haplotypes and anti-tuberculosis drug-induced hepatitis in a Chinese cohort. (23460870)
2013
3
Hyperacute drug-induced hepatitis with intravenous amiodarone: case report and review of the literature. (24109195)
2013
4
Anti-tuberculosis drug-induced hepatitis in renal transplant patient with pulmonary and extra pulmonary tuberculosis. (23960791)
2012
5
A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma. (22916049)
2012
6
TNF-I+ genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis. (22151084)
2012
7
Drug-induced hepatitis following use of octreotide for long-term treatment of congenital hyperinsulinism. (22850563)
2012
8
Relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury]. (21586239)
2011
9
Incidence, clinical and epidemiological risk factors, and outcome of drug-induced hepatitis due to antituberculous agents in new tuberculosis cases. (19535968)
2010
10
NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. (20392357)
2010
11
Drug-induced hepatitis and lupus during infliximab treatment for psoriasis: case report and literature review. (20338127)
2010
12
The effect of GST M1 and GST T1 gene mutations on anti-tuberculous drug induced hepatic injury]. (19576039)
2009
13
Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis. (19891553)
2009
14
Acute drug-induced hepatitis caused by albendazole. (18955802)
2008
15
Acute drug induced hepatitis due to erlotinib. (17228132)
2007
16
Drug induced hepatitis with anti-tubercular chemotherapy: challenges and difficulties in treatment. (18604033)
2007
17
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant. (16728538)
2006
18
Drug-induced hepatitis in a patient with malignant melanoma treated with interferon alfa 2b adjuvantly who had been administered gemfibrozil in therapy. (16645237)
2006
19
Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis. (16467335)
2006
20
A case of acute drug-induced hepatitis. (16607204)
2006
21
Drug-induced hepatitis with saquinavir/ritonavir + rifampin. (15828118)
2005
22
Drug-induced hepatitis, drug-induced autoimmunity or classical autoimmune hepatitis: how can we differentiate? (15492907)
2004
23
Secular increase in the incidence rate of drug-induced hepatitis due to anti-tuberculosis chemotherapy including isoniazid and rifampicin]. (12739393)
2003
24
Antituberculosis drug-induced hepatitis: risk factors, prevention and management. (15332488)
2003
25
Drug-induced hepatitis with autoimmune features during minocycline therapy. (12583618)
2003
26
Clinical pharmacology consultations: consultation requests may be misleading -- an organized approach to drug-induced hepatitis. (12879142)
2003
27
Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. (12668988)
2003
28
Drug-induced hepatitis with hepatic granuloma due to saridon. (12522541)
2002
29
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. (11915035)
2002
30
Comment: history of drug-induced hepatitis and risk of amoxicillin/clavulanate-induced hepatotoxicity. (11793648)
2001
31
Effects of the enterosorbent SUMS-1 on isoniazid pharmacokinetics and lipid peroxidation in patients with pulmonary tuberculosis and drug-induced hepatic lesions]. (11508231)
2001
32
Drug-induced hepatitis]. (10647202)
1999
33
Nonsteroidal antiinflammatory drug-induced hepatitis. (9533071)
1998
34
Diagnostic value of T cell reactivity in drug induced hepatitis. (9917196)
1998
35
Immunoallergic drug-induced hepatitis: lessons from halothane. (9138123)
1997
36
Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis. (9138125)
1997
37
Evidence of antibodies to erythromycin in serum of a patient following an episode of acute drug-induced hepatitis. (8735873)
1996
38
Dystonia and drug-induced hepatitis in a patient treated with clozapine. (7694924)
1995
39
Role of reactive metabolites in drug-induced hepatitis. (8551007)
1995
40
Lymphocyte reactivity to ex-vivo drug antigens in drug-induced hepatitis. (7989705)
1994
41
Antituberculosis drug-induced hepatitis and HBsAg carriers. (8369519)
1993
42
Drug induced hepatitis. (1784106)
1991
43
Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. (1937386)
1991
44
Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. (3540968)
1987
45
Drug-induced hepatitis and lymphocyte transformation test in presence of prostaglandin inhibitor. (2871443)
1986
46
Antituberculosis drug-induced hepatitis--the dangers of rechallenge. (3764619)
1986
47
Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies. (4029887)
1985
48
Drug induced hepatitis. (7156818)
1982
49
Leukocyte migration inhibition induced by the combination of drug and a liver constituent in patients with drug-induced hepatitis. (81789)
1978
50
Recognition, prevention, and treatment of drug-induced hepatitis. (5766633)
1969

Variations for Drug-Induced Hepatitis

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Expression for genes affiliated with Drug-Induced Hepatitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Drug-Induced Hepatitis

Search GEO for disease gene expression data for Drug-Induced Hepatitis.

Pathways for genes affiliated with Drug-Induced Hepatitis

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Sources:
51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 56Reactome, 13EMD Millipore
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Pathways related to Drug-Induced Hepatitis according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0UGT1A1, GSTT1
210.0CYP2E1, CYP2C19
310.0CYP2C9, UGT1A3
49.9GSTT1, GSTM1
59.9CYP2E1, CYP2C9
69.9CYP2C9, UGT1A1
7
Show member pathways
Codeine and morphine metabolism39
9.9CYP2D6, UGT1A1
8
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
9.8UGT1A3, UGT1A1, CYP2E1
99.8CYP2E1, UGT1A1, UGT1A3
10
Show member pathways
acetate conversion to acetyl-CoA39
oxidative ethanol degradation III39
ethanol degradation IV39
9.8CYP2E1, CAT
11
Show member pathways
9.7UGT1A3, UGT1A1, GSTM1
12
Show member pathways
Catalytic cycle of mammalian FMOs39
9.7GSTM1, NAT1, NAT2
13
Show member pathways
9.6CYP2C19, CYP2C9, CYP2E1
14
Show member pathways
9.6UGT1A3, UGT1A1, NAT2, NAT1
15
Show member pathways
9.5CYP2C19, CYP2D6, CYP2C9
169.5UGT1A1, CYP2D6, CYP2E1, NAT2
17
Show member pathways
9.5CYP2C9, CYP2E1, NAT2, NAT1
189.4CYP2C9, CYP2E1, GSTM1, GSTT1
199.3GHR, CYP2C9, CYP2C19
20
Show member pathways
9.3CYP2E1, CYP2C9, CYP2D6, CYP2C19
21
Show member pathways
9.3UGT1A1, CYP2C19, CYP2D6, CYP2C9
22
Show member pathways
Retinol metabolism61
9.1CYP2E1, CYP2C9, CYP2D6, CYP2C19, UGT1A3
23
Show member pathways
9.1UGT1A3, UGT1A1, CYP2C19, CYP2D6, CYP2C9
24
Show member pathways
thioredoxin pathway39
8.6ALB, CAT, TNF
25
Show member pathways
7.8UGT1A3, GSTT1, GSTM1, NAT1, NAT2, CYP2E1
26
Show member pathways
7.8CYP2E1, CYP2C9, CYP2D6, CYP2C19, UGT1A1, UGT1A3
27
Show member pathways
5.6GLUD1, GSTT1, GSTM1, ALB, CAT, NAT1

Compounds for genes affiliated with Drug-Induced Hepatitis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Drug-Induced Hepatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 595)
idCompoundScoreTop Affiliating Genes
1thiopurine469.5CYP2C19, CYP2D6, NAT2, CYP2C9
2flunitrazepam30 46 1211.5CYP2E1, UGT1A3, UGT1A1, CYP2C19, CYP2C9
3mephenytoin46 52 1211.4CYP2C19, CYP2E1, NAT2, CYP2D6, CYP2C9
4trichloroethylene469.4GSTM1, CYP2E1, GSTT1, GPT, NAT2
5cotinine46 2510.3GSTT1, UGT1A3, GSTM1, NAT2, CYP2D6, UGT1A1
6gsts469.3NAT2, GSTT1, CYP2D6, GSTM1, NAT1, CYP2E1
7arylamine469.2CYP2C19, NAT2, NAT1, GSTM1, GSTT1, CYP2D6
8debrisoquine46 5210.2CYP2E1, GSTM1, NAT2, CYP2C9, CYP2D6, CYP2C19
9tolbutamide46 30 52 1212.2GLUD1, CYP2E1, CYP2C19, NAT2, CYP2D6, CYP2C9
10paraxanthine46 2510.2NAT2, NAT1, CYP2C19, CYP2D6, CYP2C9, CYP2E1
11dapsone46 3 52 1212.2CYP2C9, CYP2D6, CYP2C19, NAT2, CYP2E1, NAT1
12Testosterone sulfate259.2CYP2E1, CYP2C9, CYP2D6, CYP2C19, UGT1A1, UGT1A3
13codeine46 30 52 25 1213.2UGT1A1, CYP2C19, CYP2D6, UGT1A3, CYP2C9, CYP2E1
14aflatoxin b146 2510.2SLC17A5, NAT1, NAT2, GSTT1, GSTM1
15chlorzoxazone46 30 1211.1CYP2D6, CYP2C9, SLC17A5, NAT2, CYP2C19, CYP2E1
16buprenorphine46 30 1211.1SLC17A5, CYP2C9, UGT1A3, CYP2D6, CYP2C19, UGT1A1
17imipramine46 30 52 25 1213.1CYP2C19, CYP2D6, UGT1A3, CYP2C9, CYP2E1, UGT1A1
18rifampin52 1210.1GSTT1, GSTM1, NAT2, UGT1A1, CYP2C19, CYP2C9
19uridine diphosphate469.1UGT1A3, NAT2, CYP2E1, CYP2C9, CYP2D6, UGT1A1
20sulfamethoxazole52 46 1210.9NAT1, GSTM1, ALB, NAT2, CYP2C9
21fluvastatin46 52 30 1211.9CYP2D6, GPT, CYP2C9, UGT1A3, UGT1A1, CYP2C19
22selegiline46 129.8CYP2C19, CYP2D6, CYP2C9, CYP2E1, CAT
23cyclophosphamide46 52 1210.7GSTT1, GSTM1, NAT2, CYP2E1, CYP2D6, CYP2C19
24phenobarbital46 30 52 1211.7CYP2E1, CYP2C9, CYP2C19, UGT1A1, GPT, GSTM1
25antipyrine46 129.7CYP2D6, ALB, CYP2C9, CYP2E1, CYP2C19, SLC17A5
26propofol46 52 1210.7UGT1A1, CYP2C19, CYP2D6, CYP2C9, CYP2E1, ALB
27diclofenac46 30 52 1211.6UGT1A3, UGT1A1, CYP2C19, CYP2D6, CYP2C9, CYP2E1
28estrone46 30 25 1211.6UGT1A3, UGT1A1, CYP2D6, CYP2C9, CYP2E1, ALB
29phenytoin46 52 30 1211.6SLC17A5, ALB, CYP2C9, UGT1A1, CYP2C19, CYP2D6
30rifampicin46 30 6210.5SLC17A5, NAT2, GPT, CYP2E1, CYP2C9, CYP2D6
31olanzapine46 52 30 25 1212.5SLC17A5, GLUD1, ALB, CYP2C9, CYP2D6, CYP2C19
32epoxide468.5GSTT1, GSTM1, NAT1, NAT2, CYP2E1, CYP2C9
33nicotine46 30 52 1211.5UGT1A3, UGT1A1, CYP2E1, GPT, CYP2C9, CYP2D6
34thalidomide46 52 62 1211.3CYP2E1, CYP2C19, CYP2C9, NAT2, TNF, GSTT1
35tamoxifen46 52 30 1211.2SLC17A5, GHR, CYP2E1, CYP2C9, CYP2D6, CYP2C19
36troglitazone46 30 62 1211.1UGT1A1, CYP2C19, UGT1A3, SLC17A5, CYP2C9, TNF
37pioglitazone30 46 52 1211.0CYP2D6, TNF, GPT, SLC17A5, CYP2C19, CYP2C9
38acetaminophen46 3 52 25 1212.0UGT1A1, CYP2C19, CYP2D6, CYP2C9, CYP2E1, GPT
39atorvastatin46 52 30 25 1211.9CYP2C19, CYP2D6, CYP2C9, GPT, TNF, SLC17A5
40valproic acid46 52 25 1210.9CYP2C19, CYP2D6, CYP2C9, CYP2E1, GPT, SLC17A5
41simvastatin46 52 62 30 25 1212.9GPT, UGT1A3, UGT1A1, CYP2C19, CYP2D6, SLC17A5
42vitamin a46 25 129.8GPT, GSTM1, NAT2, CYP2E1, CAT, SLC17A5
43estradiol46 25 129.6ALB, UGT1A3, UGT1A1, CYP2C19, CYP2E1, GHR
44rosiglitazone30 46 52 25 1211.6GPT, CYP2C9, CYP2C19, CYP2D6, TNF, ALB
45uric acid46 258.6GHR, SLC17A5, GPT, GLUD1, ALB, CAT
46isoniazid46 52 129.5CYP2C19, CYP2D6, CYP2C9, CYP2E1, GPT, NAT2
47creatinine467.3SLC17A5, CYP2E1, GPT, SORD, GLUD1, GSTT1
48testosterone46 62 25 129.9UGT1A3, GSTM1, ALB, GHR, CYP2E1, CYP2C9
49lactate466.9SLC17A5, GLUD1, GSTM1, ALB, CAT, SORD
50oxygen46 257.7CYP2D6, GHR, TNF, CYP2E1, GSTM1, GSTT1

GO Terms for genes affiliated with Drug-Induced Hepatitis

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Sources:
17Gene Ontology
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Cellular components related to Drug-Induced Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057898.8CYP2E1, CYP2C9, CYP2D6, CYP2C19, UGT1A1, UGT1A3

Biological processes related to Drug-Induced Hepatitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1xenobiotic glucuronidationGO:05269710.2UGT1A3, UGT1A1
2flavonoid glucuronidationGO:05269610.2UGT1A3, UGT1A1
3retinoic acid metabolic processGO:04257310.0UGT1A1, UGT1A3
4drug catabolic processGO:04273710.0CYP2D6, CYP2C9
5omega-hydroxylase P450 pathwayGO:0972679.9CYP2C19, CYP2C9
6oxidative demethylationGO:0709899.8CYP2D6, CYP2C9
7exogenous drug catabolic processGO:0427389.8CYP2C9, CYP2C19
8heterocycle metabolic processGO:0464839.6UGT1A1, CYP2C19, CYP2D6, CYP2E1
9monoterpenoid metabolic processGO:0160989.6CYP2C19, CYP2D6, CYP2C9, CYP2E1
10epoxygenase P450 pathwayGO:0193739.6CYP2C9, CYP2C19
11drug metabolic processGO:0171449.3UGT1A1, CYP2C19, CYP2D6, CYP2C9, CYP2E1
12steroid metabolic processGO:0082029.3UGT1A1, CYP2C19, CYP2D6, CYP2C9, CYP2E1
13oxidation-reduction processGO:0551149.3CYP2C19, CYP2D6, CYP2C9, CYP2E1, GSTT1
14cellular amino acid biosynthetic processGO:0086529.2GLUD1, TNF, GPT
15response to drugGO:0424939.1GSTT1, TNF, CYP2E1, UGT1A1
16xenobiotic metabolic processGO:0068058.3GSTT1, UGT1A1, CYP2C19, CYP2D6, CYP2C9, CYP2E1
17small molecule metabolic processGO:0442816.6CYP2E1, CYP2C9, CYP2D6, CYP2C19, UGT1A1, GPT

Molecular functions related to Drug-Induced Hepatitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1arylamine N-acetyltransferase activityGO:00406010.1NAT2, NAT1
2(R)-limonene 6-monooxygenase activityGO:05274110.1CYP2C19, CYP2C9
3(S)-limonene 7-monooxygenase activityGO:01867610.1CYP2C19, CYP2C9
4(S)-limonene 6-monooxygenase activityGO:01867510.0CYP2C19, CYP2C9
5monooxygenase activityGO:0044979.6CYP2E1, CYP2C9, CYP2D6, CYP2C19
6steroid hydroxylase activityGO:0083959.6CYP2C9, CYP2C19
7oxidoreductase activityGO:0164919.5CYP2C19, CYP2D6, CYP2C9, CYP2E1
8oxygen bindingGO:0198259.4CYP2C19, CYP2E1, ALB
9antioxidant activityGO:0162099.4ALB, CAT
10iron ion bindingGO:0055069.4CYP2E1, CYP2C9, CYP2D6, CYP2C19
11drug bindingGO:0081449.2CYP2D6, CYP2C9, ALB
12heme bindingGO:0200379.1CYP2C19, CYP2D6, CYP2C9, CYP2E1, CAT
13protein homodimerization activityGO:0428038.7UGT1A3, UGT1A1, GHR, CAT, GSTM1
14enzyme bindingGO:0198998.4GSTM1, UGT1A3, UGT1A1, CYP2C19, CYP2E1, CAT

Products for genes affiliated with Drug-Induced Hepatitis

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  • Antibodies
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Sources for Drug-Induced Hepatitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet