MCID: DRG002
MIFTS: 41

Drug-Induced Hepatitis

Categories: Liver diseases, Gastrointestinal diseases

Aliases & Classifications for Drug-Induced Hepatitis

MalaCards integrated aliases for Drug-Induced Hepatitis:

Name: Drug-Induced Hepatitis 37 12 14
Chemical and Drug Induced Liver Injury, Chronic 41
Hepatitis, Chronic, Drug-Induced 69
Drug-Induced Chronic Hepatitis 12
Hepatitis, Drug-Induced 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2044
MeSH 41 D056487
SNOMED-CT 64 235889003

Summaries for Drug-Induced Hepatitis

MalaCards based summary : Drug-Induced Hepatitis, also known as chemical and drug induced liver injury, chronic, is related to hepatitis and isoniazid toxicity. An important gene associated with Drug-Induced Hepatitis is NAT2 (N-Acetyltransferase 2), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Acetylcysteine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include Liver, liver and testes.

Related Diseases for Drug-Induced Hepatitis

Diseases related to Drug-Induced Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 hepatitis 10.6
2 isoniazid toxicity 10.4 CYP2E1 NAT2
3 methemoglobinemia 10.3 CYP2E1 NAT2
4 hearing loss, noise-induced 10.3 GSTM1 GSTT1
5 isolated cleft lip 10.3 GSTM1 GSTT1
6 oral leukoplakia 10.3 GSTM1 GSTT1
7 halothane hepatitis 10.2 CYP2C9 CYP2E1
8 leukoplakia 10.2 GSTM1 GSTT1
9 arteritic anterior ischemic optic neuropathy 10.2 GSTM1 GSTT1
10 mycobacterium tuberculosis 1 10.2
11 oligospermia 10.2 GSTM1 GSTT1
12 senile cataract 10.2 GSTM1 GSTT1
13 diffuse gastric cancer 10.2 GSTM1 GSTT1
14 xeroderma pigmentosum, complementation group d 10.2 GSTM1 GSTT1
15 asbestosis 10.2 GSTM1 GSTT1
16 ischemic optic neuropathy 10.1 GSTM1 GSTT1
17 esophageal candidiasis 10.1 CYP2C19 CYP2C9
18 oral submucous fibrosis 10.1 GSTM1 GSTT1
19 clopidogrel resistance 10.1 CYP2C19 CYP2C9
20 antidepressant or antipsychotic toxicity or dose selection 10.1 CYP2C19 CYP2D6
21 varicocele 10.1 GSTM1 GSTT1
22 alcoholic liver cirrhosis 10.1 CYP2E1 GSTM1 NAT2
23 acute lymphoblastic leukemia, childhood 10.1 GSTM1 GSTT1
24 mutagen sensitivity 10.1 GSTM1 GSTT1 NAT2
25 sister chromatid exchange, frequency of 10.0 CYP2E1 GSTM1 GSTT1
26 larynx cancer 10.0 GSTM1 GSTT1 NAT2
27 pulmonary tuberculosis 10.0
28 toxic encephalopathy 10.0 GSTM1 GSTT1
29 nasopharyngeal carcinoma 10.0 CYP2E1 GSTM1 GSTT1
30 toxic oil syndrome 9.9 CYP2D6 GSTM1 NAT2
31 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
32 oral cancer 9.9 GSTM1 GSTT1
33 basal cell carcinoma 9.9 CYP2D6 GSTM1 GSTT1
34 hepatitis b 9.8
35 hepatitis a 9.8
36 meningitis 9.8
37 oral cavity cancer 9.8 GSTM1 GSTT1
38 hepatitis d 9.7 CYP2C9 CYP2D6 IFNL3
39 blood group--diego system 9.6
40 myeloma, multiple 9.6
41 hyperinsulinemic hypoglycemia, familial, 3 9.6
42 hyperinsulinemic hypoglycemia, familial, 5 9.6
43 hyperinsulinemic hypoglycemia, familial, 4 9.6
44 autoimmune hepatitis 9.6
45 melanoma 9.6
46 hyperinsulinism 9.6
47 pustulosis of palm and sole 9.6
48 dystonia 9.6
49 psoriasis 9.6
50 tuberculous meningitis 9.6

Graphical network of the top 20 diseases related to Drug-Induced Hepatitis:



Diseases related to Drug-Induced Hepatitis

Symptoms & Phenotypes for Drug-Induced Hepatitis

Drugs & Therapeutics for Drug-Induced Hepatitis

Drugs for Drug-Induced Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Antitubercular Agents Phase 2, Phase 3
5 Respiratory System Agents Phase 2, Phase 3
6 N-monoacetylcystine Phase 2, Phase 3
7 Antidotes Phase 2, Phase 3
8 Expectorants Phase 2, Phase 3
9 Protective Agents Phase 2, Phase 3
10 Liver Extracts Phase 2, Phase 3
11 Antioxidants Phase 2, Phase 3
12 Antiviral Agents Phase 2, Phase 3
13
Rifampin Approved 13292-46-1 5381226 5458213
14
Isoniazid Approved, Investigational 54-85-3 3767
15
Pyrazinamide Approved, Investigational 98-96-4 1046

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis Recruiting NCT02182167 Phase 2, Phase 3 IV N-acetylcysteine (NAC);Water
2 Prospective Study of N-acetyltransferase2 (NAT2) and Cytochrome P4502E1 (CYP2E1) Gene as Susceptible Risk Factors for Antituberculosis (ATT) Induced Hepatitis Completed NCT00834353 ATT
3 Anti-tuberculosis (TB) Drug Levels and Hepatotoxicity Completed NCT00929786

Search NIH Clinical Center for Drug-Induced Hepatitis

Cochrane evidence based reviews: chemical and drug induced liver injury, chronic

Genetic Tests for Drug-Induced Hepatitis

Anatomical Context for Drug-Induced Hepatitis

MalaCards organs/tissues related to Drug-Induced Hepatitis:

38
Liver, Testes, T Cells
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Drug-Induced Hepatitis:
# Tissue Anatomical CompartmentCell Relevance
1 Liver Liver Lobule Hepatocytes Affected by disease

Publications for Drug-Induced Hepatitis

Articles related to Drug-Induced Hepatitis:

(show top 50) (show all 98)
# Title Authors Year
1
Is drug-induced hepatitis related to the severity of tuberculous meningitis? ( 29438557 )
2018
2
Baseline HBV load increases the risk of anti-tuberculous drug-induced hepatitis flares in patients with tuberculosis. ( 28224437 )
2017
3
Compensatory variances of drug-induced hepatitis B virus YMDD mutations. ( 27588233 )
2016
4
Troxis necrosis, a novel mechanism for drug-induced hepatitis secondary to immunomodulatory therapy. ( 26297838 )
2015
5
Drug-induced hepatitis and the risk factors for liver injury in pulmonary tuberculosis patients. ( 25949974 )
2015
6
Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis. ( 25553268 )
2015
7
Analysis of IL-6, STAT3 and HSPA1L Gene Polymorphisms in Anti-Tuberculosis Drug-Induced Hepatitis in a Nested Case-Control Study. ( 25789467 )
2015
8
Characteristics of Mononuclear Extracellular Traps in the Offspring of Female Rats with Drug-Induced Hepatitis. ( 26388577 )
2015
9
Recurrent Drug-Induced Hepatitis in Tuberculosis-Comparison of Two Drug Regimens. ( 26057141 )
2015
10
Risk factors for drug-induced hepatitis with first-line antituberculosis drugs in hospitalized patients of pulmonary tuberculosis. ( 24823543 )
2014
11
Epstein-Barr Virus Infection Mimicking Drug-Induced Hepatitis in a Critically ill Patient During Antituberculosis Therapy. ( 25368656 )
2014
12
Is antiviral drug-induced hepatitis B surface antigen loss durable? ( 25457852 )
2014
13
Comments on 'Risk factors for drug induced hepatitis with first-line antituberculosis drugs in hospitalized patients of pulmonary tuberculosis'. ( 24823542 )
2014
14
Risk factors for drug induced hepatitis with first-line antituberculosis drugs in hospitalized patients of pulmonary tuberculosis. ( 24625953 )
2014
15
Authors' reply to Comment on "No impact of interleukin-28B polymorphisms on spontaneous or drug-induced hepatitis delta virus clearance" [Dig. Liver Dis.2014;46:348-52]. ( 24890620 )
2014
16
Comment on "No impact of interleukin-28B polymorphisms on spontaneous or drug-induced hepatitis delta virus clearance" by Ubaldo Visco-Comandini et al. [Dig. Liver Dis. 2014;46:348-52]. ( 24815081 )
2014
17
No impact of interleukin-28B polymorphisms on spontaneous or drug-induced hepatitis delta virus clearance. ( 24387833 )
2013
18
Hyperacute drug-induced hepatitis with intravenous amiodarone: case report and review of the literature. ( 24109195 )
2013
19
A rare coexistence: drug induced hepatitis and meningitis in association with Ibuprofen. ( 23671551 )
2013
20
Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis. ( 24035958 )
2013
21
Cytochrome P450 2E1 gene polymorphisms/haplotypes and anti-tuberculosis drug-induced hepatitis in a Chinese cohort. ( 23460870 )
2013
22
A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma. ( 22916049 )
2012
23
A rare cause of drug-induced hepatitis in an immunocompromised patient and the role of glutathione. ( 22993667 )
2012
24
TNF-I+ genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis. ( 22151084 )
2012
25
Drug-induced hepatitis following use of octreotide for long-term treatment of congenital hyperinsulinism. ( 22850563 )
2012
26
Anti-tuberculosis drug-induced hepatitis in renal transplant patient with pulmonary and extra pulmonary tuberculosis. ( 23960791 )
2012
27
Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients. ( 22012226 )
2011
28
A Case of Drug-Induced Hepatitis due to Lenalidomide. ( 21552449 )
2011
29
[Relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury]. ( 21586239 )
2011
30
Remission of drug-induced hepatitis after switching from risperidone to paliperidone. ( 20194492 )
2010
31
Zhixue capsule caused seven cases of drug induced hepatitis. ( 20698229 )
2010
32
Drug-induced hepatitis and lupus during infliximab treatment for psoriasis: case report and literature review. ( 20338127 )
2010
33
NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. ( 20392357 )
2010
34
Incidence, clinical and epidemiological risk factors, and outcome of drug-induced hepatitis due to antituberculous agents in new tuberculosis cases. ( 19535968 )
2010
35
[The effect of GST M1 and GST T1 gene mutations on anti-tuberculous drug induced hepatic injury]. ( 19576039 )
2009
36
Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis. ( 19891553 )
2009
37
Acute drug-induced hepatitis caused by albendazole. ( 18955802 )
2008
38
Prevalence and risk factors of anti-tuberculosis drug-induced hepatitis in Malaysia. ( 18830542 )
2008
39
Determining the relation between N-acetyltransferase-2 acetylator phenotype and antituberculosis drug induced hepatitis by molecular biologic tests. ( 18330759 )
2008
40
Drug-induced hepatitis superimposed on the presence of anti-SLA antibody: a case report. ( 18226219 )
2008
41
Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. ( 16875890 )
2007
42
Acute drug induced hepatitis secondary to a weight loss product purchased over the internet. ( 17597525 )
2007
43
Acute drug induced hepatitis due to erlotinib. ( 17228132 )
2007
44
Drug-induced hepatitis - morphological and ultrastructural aspects. ( 18060200 )
2007
45
Drug induced hepatitis with anti-tubercular chemotherapy: challenges and difficulties in treatment. ( 18604033 )
2007
46
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant. ( 16728538 )
2006
47
Drug-induced hepatitis in a patient with malignant melanoma treated with interferon alfa 2b adjuvantly who had been administered gemfibrozil in therapy. ( 16645237 )
2006
48
Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis. ( 16467335 )
2006
49
Mitochondrial involvement in drug-induced hepatic injury. ( 16889760 )
2006
50
A case of acute drug-induced hepatitis. ( 16607204 )
2006

Variations for Drug-Induced Hepatitis

Expression for Drug-Induced Hepatitis

Search GEO for disease gene expression data for Drug-Induced Hepatitis.

Pathways for Drug-Induced Hepatitis

Pathways related to Drug-Induced Hepatitis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CYP2C19 CYP2C9 CYP2D6 CYP2E1 GSTM1 GSTT1
2
Show member pathways
12.93 CYP2C19 CYP2C9 CYP2D6 CYP2E1 GSTM1 GSTT1
3
Show member pathways
11.91 CYP2C19 CYP2C9 CYP2D6 CYP2E1 GSTM1 GSTT1
4
Show member pathways
11.79 CYP2C19 CYP2C9 CYP2E1
5 11.77 CYP2C19 CYP2C9 CYP2D6
6
Show member pathways
11.67 CYP2C19 CYP2C9 CYP2D6 UGT1A3
7
Show member pathways
11.55 CYP2D6 CYP2E1 GSTM1 GSTT1 UGT1A3
8 11.51 GSTM1 GSTT1
9
Show member pathways
11.46 CYP2C19 CYP2C9 CYP2D6
10
Show member pathways
11.45 CYP2E1 UGT1A3
11
Show member pathways
11.45 CYP2C19 CYP2C9 CYP2D6 CYP2E1
12
Show member pathways
11.45 CYP2C19 CYP2C9 CYP2D6 CYP2E1 UGT1A3
13
Show member pathways
11.37 CYP2C19 CYP2C9
14 11.34 CYP2C19 CYP2C9
15
Show member pathways
11.27 GSTM1 NAT2
16 11.19 CYP2C19 CYP2D6
17 11.16 CYP2C9 CYP2E1
18 11.16 CYP2C19 CYP2C9 UGT1A3
19
Show member pathways
11.14 GSTM1 UGT1A3
20
Show member pathways
11.14 CYP2C19 CYP2C9 CYP2D6 CYP2E1 UGT1A3
21 11.06 GSTM1 GSTT1
22
Show member pathways
11.05 CYP2C9 CYP2E1 NAT2
23 11.05 CYP2C9 CYP2E1 GSTM1 GSTT1
24
Show member pathways
11.02 CYP2C9 CYP2E1
25 10.91 CYP2C9 UGT1A3
26 10.88 CYP2C9 CYP2E1
27 10.71 CYP2D6 UGT1A3
28 10.67 CYP2C9 UGT1A3
29 10.29 CYP2E1 GSTM1

GO Terms for Drug-Induced Hepatitis

Cellular components related to Drug-Induced Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.65 CYP2C19 CYP2C9 CYP2D6 CYP2E1 UGT1A3
2 endoplasmic reticulum membrane GO:0005789 9.55 CYP2C19 CYP2C9 CYP2D6 CYP2E1 UGT1A3
3 intracellular membrane-bounded organelle GO:0043231 9.35 CYP2C19 CYP2C9 CYP2D6 CYP2E1 UGT1A3
4 organelle membrane GO:0031090 8.92 CYP2C19 CYP2C9 CYP2D6 CYP2E1

Biological processes related to Drug-Induced Hepatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.81 CYP2C19 CYP2C9 CYP2D6 CYP2E1
2 steroid metabolic process GO:0008202 9.67 CYP2C19 CYP2C9 CYP2D6 CYP2E1
3 glutathione metabolic process GO:0006749 9.52 GSTM1 GSTT1
4 epoxygenase P450 pathway GO:0019373 9.5 CYP2C19 CYP2C9 CYP2E1
5 glutathione derivative biosynthetic process GO:1901687 9.49 GSTM1 GSTT1
6 exogenous drug catabolic process GO:0042738 9.48 CYP2C19 CYP2C9
7 omega-hydroxylase P450 pathway GO:0097267 9.46 CYP2C19 CYP2C9
8 drug metabolic process GO:0017144 9.46 CYP2C19 CYP2C9 CYP2D6 CYP2E1
9 oxidative demethylation GO:0070989 9.43 CYP2C9 CYP2D6
10 heterocycle metabolic process GO:0046483 9.43 CYP2C19 CYP2D6 CYP2E1
11 drug catabolic process GO:0042737 9.4 CYP2C9 CYP2D6
12 xenobiotic metabolic process GO:0006805 9.35 CYP2C19 CYP2C9 CYP2D6 CYP2E1 NAT2
13 monoterpenoid metabolic process GO:0016098 8.92 CYP2C19 CYP2C9 CYP2D6 CYP2E1

Molecular functions related to Drug-Induced Hepatitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.76 CYP2C19 CYP2C9 CYP2D6 CYP2E1
2 iron ion binding GO:0005506 9.71 CYP2C19 CYP2C9 CYP2D6 CYP2E1
3 enzyme binding GO:0019899 9.67 CYP2C19 CYP2E1 GSTM1
4 heme binding GO:0020037 9.67 CYP2C19 CYP2C9 CYP2D6 CYP2E1
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.56 CYP2C19 CYP2C9 CYP2D6 CYP2E1
6 drug binding GO:0008144 9.51 CYP2C9 CYP2D6
7 arachidonic acid epoxygenase activity GO:0008392 9.5 CYP2C19 CYP2C9 CYP2E1
8 glutathione transferase activity GO:0004364 9.48 GSTM1 GSTT1
9 monooxygenase activity GO:0004497 9.46 CYP2C19 CYP2C9 CYP2D6 CYP2E1
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.43 CYP2D6 CYP2E1
11 oxygen binding GO:0019825 9.26 CYP2C19 CYP2C9 CYP2D6 CYP2E1
12 steroid hydroxylase activity GO:0008395 8.92 CYP2C19 CYP2C9 CYP2D6 CYP2E1

Sources for Drug-Induced Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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