MCID: DRG013
MIFTS: 29

Drug-Induced Lupus Erythematosus

Categories: Bone diseases, Skin diseases, Rare diseases

Aliases & Classifications for Drug-Induced Lupus Erythematosus

MalaCards integrated aliases for Drug-Induced Lupus Erythematosus:

Name: Drug-Induced Lupus Erythematosus 55 69
Dile 55

Characteristics:

Orphanet epidemiological data:

55
drug-induced lupus erythematosus
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



Summaries for Drug-Induced Lupus Erythematosus

MalaCards based summary : Drug-Induced Lupus Erythematosus, also known as dile, is related to lupus erythematosus and splenomegaly, and has symptoms including hematuria, petechiae and pericardial effusion. The drugs Infliximab and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and smooth muscle.

Wikipedia : 72 Drug-induced lupus erythematosus (DIL or DILE) is an autoimmune disorder (similar to systemic lupus... more...

Related Diseases for Drug-Induced Lupus Erythematosus

Diseases related to Drug-Induced Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 lupus erythematosus 10.6
2 splenomegaly 10.0
3 blood group, i system 9.8
4 thrombocytopenia 9.8
5 lymphoma 9.8
6 cardiac tamponade 9.8
7 hypoglycemia 9.8

Graphical network of the top 20 diseases related to Drug-Induced Lupus Erythematosus:



Diseases related to Drug-Induced Lupus Erythematosus

Symptoms & Phenotypes for Drug-Induced Lupus Erythematosus

Human phenotypes related to Drug-Induced Lupus Erythematosus:

55 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematuria 55 31 hallmark (90%) Very frequent (99-80%) HP:0000790
2 petechiae 55 31 hallmark (90%) Very frequent (99-80%) HP:0000967
3 pericardial effusion 55 31 hallmark (90%) Very frequent (99-80%) HP:0001698
4 pericarditis 55 31 hallmark (90%) Very frequent (99-80%) HP:0001701
5 thrombocytopenia 55 31 hallmark (90%) Very frequent (99-80%) HP:0001873
6 anemia 55 31 hallmark (90%) Very frequent (99-80%) HP:0001903
7 dyspnea 55 31 hallmark (90%) Very frequent (99-80%) HP:0002094
8 arthralgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0002829
9 increased blood urea nitrogen 55 31 hallmark (90%) Very frequent (99-80%) HP:0003138
10 elevated serum creatine phosphokinase 55 31 hallmark (90%) Very frequent (99-80%) HP:0003236
11 myalgia 55 31 hallmark (90%) Very frequent (99-80%) HP:0003326
12 antinuclear antibody positivity 55 31 hallmark (90%) Very frequent (99-80%) HP:0003493
13 elevated erythrocyte sedimentation rate 55 31 hallmark (90%) Very frequent (99-80%) HP:0003565
14 prolonged qtc interval 55 31 hallmark (90%) Very frequent (99-80%) HP:0005184
15 decreased serum complement c3 55 31 hallmark (90%) Very frequent (99-80%) HP:0005421
16 elevated c-reactive protein level 55 31 hallmark (90%) Very frequent (99-80%) HP:0011227
17 malar rash 55 31 hallmark (90%) Very frequent (99-80%) HP:0025300
18 lupus anticoagulant 55 31 hallmark (90%) Very frequent (99-80%) HP:0025343
19 decreased serum complement c4 55 31 hallmark (90%) Very frequent (99-80%) HP:0045042
20 fever 55 31 frequent (33%) Frequent (79-30%) HP:0001945
21 autoimmune antibody positivity 55 Very frequent (99-80%)
22 serositis 55 Frequent (79-30%)
23 constitutional symptom 55 Occasional (29-5%)

Drugs & Therapeutics for Drug-Induced Lupus Erythematosus

Drugs for Drug-Induced Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved 170277-31-3
2 Gastrointestinal Agents
3 Dermatologic Agents
4 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 a Single-center Registered Clinical Research of Chinese Patients With Moderate to Severe Crohn's Disease Unknown status NCT02088944 Infliximab

Search NIH Clinical Center for Drug-Induced Lupus Erythematosus

Genetic Tests for Drug-Induced Lupus Erythematosus

Anatomical Context for Drug-Induced Lupus Erythematosus

MalaCards organs/tissues related to Drug-Induced Lupus Erythematosus:

38
Skin, Bone, Smooth Muscle, Testes, Skeletal Muscle

Publications for Drug-Induced Lupus Erythematosus

Articles related to Drug-Induced Lupus Erythematosus:

(show all 45)
# Title Authors Year
1
A case of lupus-like syndrome in a patient receiving adalimumab and a brief review of the literature on drug-induced lupus erythematosus. ( 28191663 )
2017
2
Drug-induced lupus erythematosus mimicking lymphoma on (18)F-FDG-PET/CT. ( 28420045 )
2017
3
Drug-Induced Lupus Erythematosus Associated with Antiretroviral Therapy in a Patient with Human Immunodeficiency Virus: A Case Report. ( 29147636 )
2017
4
A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade. ( 27357280 )
2016
5
Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia. ( 26710505 )
2015
6
Drug-induced lupus erythematosus associated with donepezil: a case report. ( 26420637 )
2015
7
Drug-induced lupus erythematosus. ( 24819757 )
2014
8
Drug-Induced Lupus Erythematosus. ( 24388458 )
2013
9
Drug-Induced Lupus Erythematosus Presenting With Cardiac Tamponade: A Case Report and Literature Review. ( 24373757 )
2013
10
Drug-induced lupus erythematosus with emphasis on skin manifestations and the role of anti-TNFI+ agents. ( 22937775 )
2012
11
Drug-Induced Lupus Erythematosus. ( 23164669 )
2012
12
Episcleritis Related to Drug-Induced Lupus Erythematosus following Infliximab Therapy: A Case Report. ( 21547267 )
2011
13
Drug-induced lupus erythematosus: incidence, management and prevention. ( 21513360 )
2011
14
Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. ( 20376687 )
2010
15
Drug reaction with herbal supplement: a possible case of drug induced lupus erythematosus. ( 25606196 )
2010
16
Drug-induced lupus erythematosus. ( 18797892 )
2009
17
Drug-induced lupus erythematosus in a patient treated with adalumimab. ( 17434034 )
2007
18
Drug-induced lupus erythematosus. ( 16373256 )
2005
19
Drug-induced lupus erythematosus. ( 15234017 )
2004
20
Drug-induced lupus erythematosus secondary to nafcillin: the first reported case. ( 14658003 )
2004
21
The utility of antihistone antibody screening in the diagnosis of drug-induced lupus erythematosus. ( 15096389 )
2004
22
Drug-induced lupus erythematosus by amiodarone. ( 11926860 )
2002
23
Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus? ( 11014349 )
2000
24
Drug-induced lupus erythematosus. ( 9642530 )
1998
25
Antibodies to dsDNA in drug induced lupus erythematosus. ( 8006909 )
1994
26
Antihistone antibodies and drug-induced lupus erythematosus. ( 3947411 )
1986
27
Reticuloendothelial system Fc receptor function in the drug induced lupus erythematosus syndrome. ( 3772920 )
1986
28
The diagnostic value of antihistone antibodies in drug-induced lupus erythematosus. ( 3882094 )
1985
29
Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. ( 6349454 )
1983
30
The heterogeneity of serologic findings and predisposing host factors in drug-induced lupus erythematosus. ( 6974553 )
1981
31
Lymphocyte alteration by procainamide: relation to drug-induced lupus erythematosus syndrome. ( 90917 )
1979
32
Drug-induced lupus erythematosus. ( 421513 )
1979
33
Drug-induced lupus erythematosus aggravated by oral zinc therapy. ( 92157 )
1979
34
Procainamide, acetylprocainamide, and drug-induced lupus erythematosus. ( 91813 )
1979
35
Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid. ( 77754 )
1978
36
Drug induced lupus erythematosus--a case report. ( 687309 )
1978
37
Drug-induced lupus erythematosus. ( 68769 )
1977
38
Drug-induced lupus erythematosus syndrome. Immuno-pathological, electronmicroscopical and serological studies. ( 4138086 )
1974
39
Medical grand rounds--from the Medical College of Virginia. Drug-induced lupus erythematosus. ( 4545011 )
1974
40
Studies on drug-induced lupus erythematosus in mice. II. Drug-induced smooth muscle and skeletal muscle antibodies. ( 4587506 )
1973
41
Studies on drug-induced lupus erythematosus in mice. 3. Renal lesions and splenomegaly in drug-induced lupus erythematosus. ( 4273216 )
1973
42
Drug-induced lupus erythematosus. ( 4803375 )
1973
43
Biologic false-positive FTA-ABS test in drug-induced lupus erythematosus. ( 4574098 )
1973
44
Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA). ( 4557182 )
1972
45
Drug-induced lupus erythematosus. ( 5473639 )
1970

Variations for Drug-Induced Lupus Erythematosus

Expression for Drug-Induced Lupus Erythematosus

Search GEO for disease gene expression data for Drug-Induced Lupus Erythematosus.

Pathways for Drug-Induced Lupus Erythematosus

GO Terms for Drug-Induced Lupus Erythematosus

Sources for Drug-Induced Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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