MCID: DRG001
MIFTS: 33

Drug Psychosis

Categories: Mental diseases

Aliases & Classifications for Drug Psychosis

MalaCards integrated aliases for Drug Psychosis:

Name: Drug Psychosis 12 14
Drug-Induced Psychotic Disorder 12
Psychoses, Substance-Induced 41
Drug-Induced Psychosis 12
Psychoses, Drug 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1742
ICD9CM 34 292.1
MeSH 41 D011605
UMLS 69 C0033937

Summaries for Drug Psychosis

MalaCards based summary : Drug Psychosis, also known as drug-induced psychotic disorder, is related to schizophrenia and schizophrenia 5. An important gene associated with Drug Psychosis is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Serotonergic synapse and GPCRs, Other. The drugs Antipsychotic Agents and Central Nervous System Depressants have been mentioned in the context of this disorder. Related phenotypes are shRNA abundance <= 50% and behavior/neurological

Related Diseases for Drug Psychosis

Diseases related to Drug Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 28.1 CNR1 DRD2 HTR1A HTR2A HTR7
2 schizophrenia 5 10.6 HTR1A HTR2A
3 schizoid personality disorder 10.6 HTR1A HTR2A
4 hypoactive sexual desire disorder 10.5 HTR1A HTR2A
5 substance-induced psychosis 10.5 HTR1A HTR2A
6 parkinson disease, mitochondrial 10.4 NDUFS4 PINK1
7 tendinitis 10.3 LHB PHB2
8 bursitis 10.3 NDUFS4 PHB2
9 polysubstance abuse 10.3 CNR1 DRD2
10 tardive dyskinesia 10.3 DRD2 HTR2A
11 anxiety 10.3 CNR1 HTR1A HTR2A
12 alcoholic psychosis 10.3 DRD2 HTR2A
13 periodic limb movement disorder 10.2 DRD2 HTR1A HTR2A
14 rumination disorder 10.2 HTR1A HTR7
15 generalized anxiety disorder 10.2 DRD2 HTR1A HTR2A
16 personality disorder 10.2 DRD2 HTR1A HTR2A
17 interval angle-closure glaucoma 10.2 IDH1 IDH2
18 adult oligodendroglioma 10.2 IDH1 IDH2
19 enchondroma 10.2 IDH1 IDH2
20 intracranial chondrosarcoma 10.2 IDH1 IDH2
21 coronary artery vasospasm 10.2 HTR2A HTR7
22 central nervous system disease 10.2 CNR1 HTR2A PINK1
23 glioma susceptibility 1 10.2 IDH1 IDH2
24 mood disorder 10.2 DRD2 HTR1A HTR2A
25 post-traumatic stress disorder 10.2 CNR1 DRD2 HTR2A
26 anaplastic oligodendroglioma 10.2 IDH1 IDH2
27 early-onset schizophrenia 10.2 DRD2 HTR2A NDUFS4
28 psychotic disorder 10.2 DRD2 HTR1A HTR2A
29 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
30 chondroblastic osteosarcoma 10.2 IDH1 IDH2
31 obsessive-compulsive disorder 10.2 DRD2 HTR1A HTR2A
32 intraductal papilloma 10.2 IDH1 IDH2
33 multiple enchondromatosis, maffucci type 10.1 IDH1 IDH2
34 psychosexual disorder 10.1 HTR1A HTR2A HTR7
35 spindle cell hemangioma 10.1 IDH1 IDH2
36 mental depression 10.1 HTR1A HTR2A HTR7
37 dysthymic disorder 10.1 HTR2A HTR7
38 bruxism 10.1 DRD2 HTR2A
39 periosteal chondrosarcoma 10.1 IDH1 IDH2
40 adult astrocytic tumour 10.0 IDH1 IDH2
41 kleptomania 10.0 HTR1A HTR7
42 fibrillary astrocytoma 10.0 IDH1 IDH2
43 undifferentiated pleomorphic sarcoma 10.0 IDH1 IDH2
44 pathological gambling 9.9 DRD2 HTR2A
45 periosteal osteogenic sarcoma 9.8 FOS IDH1
46 capgras syndrome 9.7
47 koro 9.7
48 motion sickness 9.7 FOS HTR1A HTR7
49 withdrawal disorder 9.6 CNR1 FOS HTR7
50 pain agnosia 9.6 CNR1 FOS HTR7

Graphical network of the top 20 diseases related to Drug Psychosis:



Diseases related to Drug Psychosis

Symptoms & Phenotypes for Drug Psychosis

GenomeRNAi Phenotypes related to Drug Psychosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.36 ADAMTS2 DRD2 DUSP26 EPHA5 FOS HTR1A

MGI Mouse Phenotypes related to Drug Psychosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 PINK1 DRD2 FOS HTR1A HTR2A HTR7
2 growth/size/body region MP:0005378 9.96 DUSP26 TCOF1 FOS IDH1 ADAMTS2 NDUFS4
3 integument MP:0010771 9.7 FOS HTR7 ADAMTS2 NDUFS4 CNR1 PHB2
4 nervous system MP:0003631 9.61 PINK1 DRD2 EPHA5 TCOF1 FOS HTR1A
5 skeleton MP:0005390 9.28 TCOF1 FOS HTR2A IDH1 ADAMTS2 NDUFS4

Drugs & Therapeutics for Drug Psychosis

Drugs for Drug Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antipsychotic Agents Phase 4
2 Central Nervous System Depressants Phase 4
3 Psychotropic Drugs Phase 4
4 Quetiapine Fumarate Phase 4 111974-72-2
5 Tranquilizing Agents Phase 4
6
Clozapine Approved 5786-21-0 2818
7 GABA Agents
8 Neurotransmitter Agents
9
Serotonin 50-67-9 5202
10 Serotonin Agents
11 Serotonin Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry Unknown status NCT00986167 Phase 4 Quetiapine XR
2 Study of Clozapine for the Treatment of Psychosis in Patients With Idiopathic Parkinson's Disease Completed NCT00004826 clozapine

Search NIH Clinical Center for Drug Psychosis

Cochrane evidence based reviews: psychoses, substance-induced

Genetic Tests for Drug Psychosis

Anatomical Context for Drug Psychosis

Publications for Drug Psychosis

Articles related to Drug Psychosis:

# Title Authors Year
1
Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia. ( 11812256 )
2002

Variations for Drug Psychosis

Expression for Drug Psychosis

Search GEO for disease gene expression data for Drug Psychosis.

Pathways for Drug Psychosis

GO Terms for Drug Psychosis

Cellular components related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.5 CNR1 DUSP26 IDH1 IDH2 NDUFS4 PHB2
2 axon GO:0030424 9.1 CNR1 DRD2 EPHA5 HTR2A PHB2 PINK1

Biological processes related to Drug Psychosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 mitochondrion organization GO:0007005 9.63 IDH2 PHB2 PINK1
2 response to light stimulus GO:0009416 9.6 DRD2 FOS
3 regulation of dopamine secretion GO:0014059 9.59 DRD2 HTR2A
4 behavioral response to cocaine GO:0048148 9.58 DRD2 HTR2A
5 temperature homeostasis GO:0001659 9.58 DRD2 HTR2A
6 G-protein coupled serotonin receptor signaling pathway GO:0098664 9.57 HTR1A HTR2A
7 smooth muscle contraction GO:0006939 9.56 HTR2A HTR7
8 2-oxoglutarate metabolic process GO:0006103 9.54 IDH1 IDH2
9 vasoconstriction GO:0042310 9.52 HTR1A HTR7
10 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.51 DRD2 HTR2A
11 regulation of synaptic transmission, GABAergic GO:0032228 9.49 CNR1 DRD2
12 behavior GO:0007610 9.48 HTR1A HTR2A
13 sleep GO:0030431 9.43 FOS HTR2A
14 regulation of behavior GO:0050795 9.4 HTR1A HTR2A
15 regulation of hormone secretion GO:0046883 9.37 HTR1A HTR2A
16 isocitrate metabolic process GO:0006102 9.32 IDH1 IDH2
17 serotonin receptor signaling pathway GO:0007210 9.26 HTR1A HTR2A
18 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.16 HTR1A HTR7
19 negative regulation of dopamine secretion GO:0033602 8.96 CNR1 DRD2
20 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2
21 G-protein coupled receptor signaling pathway GO:0007186 10.02 CNR1 DRD2 HTR1A HTR2A HTR7 LHB

Molecular functions related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.71 CNR1 DRD2 HTR1A HTR2A
2 drug binding GO:0008144 9.54 CNR1 DRD2 HTR2A
3 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR2A HTR7
4 isocitrate dehydrogenase activity GO:0004448 9.32 IDH1 IDH2
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.26 IDH1 IDH2
6 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR2A HTR7
7 serotonin binding GO:0051378 8.8 HTR1A HTR2A HTR7

Sources for Drug Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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