MCID: DRG012
MIFTS: 37

Drug Rash with Eosinophilia and Systemic Symptoms

Categories: Skin diseases, Immune diseases, Rare diseases

Aliases & Classifications for Drug Rash with Eosinophilia and Systemic Symptoms

MalaCards integrated aliases for Drug Rash with Eosinophilia and Systemic Symptoms:

Name: Drug Rash with Eosinophilia and Systemic Symptoms 55
Drug Reaction Eosinophilic Systemic Syndrome 55
Drug Hypersensitivity Syndrome 69
Dress Syndrome 55

Characteristics:

Orphanet epidemiological data:

55
drug rash with eosinophilia and systemic symptoms
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



Summaries for Drug Rash with Eosinophilia and Systemic Symptoms

MalaCards based summary : Drug Rash with Eosinophilia and Systemic Symptoms, also known as drug reaction eosinophilic systemic syndrome, is related to allergic hypersensitivity disease and myocarditis, and has symptoms including renal insufficiency, nephrotic syndrome and skin rash. The drugs Dapsone and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and thyroid.

Related Diseases for Drug Rash with Eosinophilia and Systemic Symptoms

Graphical network of the top 20 diseases related to Drug Rash with Eosinophilia and Systemic Symptoms:



Diseases related to Drug Rash with Eosinophilia and Systemic Symptoms

Symptoms & Phenotypes for Drug Rash with Eosinophilia and Systemic Symptoms

Human phenotypes related to Drug Rash with Eosinophilia and Systemic Symptoms:

55 31 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0000083
2 nephrotic syndrome 55 31 occasional (7.5%) Occasional (29-5%) HP:0000100
3 skin rash 55 31 hallmark (90%) Very frequent (99-80%) HP:0000988
4 erythroderma 55 31 hallmark (90%) Very frequent (99-80%) HP:0001019
5 cardiac arrest 55 31 hallmark (90%) Very frequent (99-80%) HP:0001695
6 weight loss 55 31 hallmark (90%) Very frequent (99-80%) HP:0001824
7 eosinophilia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001880
8 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
9 tubulointerstitial nephritis 55 31 occasional (7.5%) Occasional (29-5%) HP:0001970
10 dyspnea 55 31 occasional (7.5%) Occasional (29-5%) HP:0002094
11 pulmonary infiltrates 55 31 frequent (33%) Frequent (79-30%) HP:0002113
12 encephalitis 55 31 hallmark (90%) Very frequent (99-80%) HP:0002383
13 lymphadenopathy 55 31 hallmark (90%) Very frequent (99-80%) HP:0002716
14 elevated hepatic transaminases 55 31 frequent (33%) Frequent (79-30%) HP:0002910
15 interstitial pneumonitis 55 31 frequent (33%) Frequent (79-30%) HP:0006515
16 acute hepatic failure 55 31 occasional (7.5%) Occasional (29-5%) HP:0006554
17 peripheral neuropathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0009830
18 erythema 55 31 hallmark (90%) Very frequent (99-80%) HP:0010783
19 hepatitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012115
20 macule 55 31 hallmark (90%) Very frequent (99-80%) HP:0012733
21 cough 55 31 occasional (7.5%) Occasional (29-5%) HP:0012735
22 myocarditis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012819
23 enanthema 55 31 occasional (7.5%) Occasional (29-5%) HP:0030249
24 immunologic hypersensitivity 55 31 hallmark (90%) Very frequent (99-80%) HP:0100326
25 thyroiditis 55 31 hallmark (90%) Very frequent (99-80%) HP:0100646
26 angioedema 55 31 hallmark (90%) Very frequent (99-80%) HP:0100665
27 lymphocytosis 55 31 frequent (33%) Frequent (79-30%) HP:0100827
28 pustule 55 31 occasional (7.5%) Occasional (29-5%) HP:0200039

Drugs & Therapeutics for Drug Rash with Eosinophilia and Systemic Symptoms

Drugs for Drug Rash with Eosinophilia and Systemic Symptoms (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Folic Acid Antagonists Phase 4
5 Vitamin B Complex Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Antimalarials Phase 4
9 Antiprotozoal Agents Phase 4
10 Antiparasitic Agents Phase 4
11 Folate Nutraceutical Phase 4
12 Vitamin B9 Nutraceutical Phase 4
13 Immunoglobulins Phase 3
14 Antibodies Phase 3
15
Prednisone Approved, Vet_approved 53-03-2 5865
16
Clobetasol Approved, Investigational 25122-41-2, 25122-46-7 5311051 32798
17
Lamotrigine Approved, Investigational 84057-84-1 3878
18
Carbamazepine Approved, Investigational 298-46-4 2554
19
Valproic Acid Approved, Investigational 99-66-1 3121
20
Etanercept Approved, Investigational 185243-69-0
21
Prednisolone Approved, Vet_approved 50-24-8 5755
22
Oxcarbazepine Approved 28721-07-5 34312
23
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
24
Methylprednisolone Approved, Vet_approved 83-43-2 6741
25
Eslicarbazepine acetate Approved 236395-14-5, 75970-99-9 123618
26 tannic acid Approved, Nutraceutical
27 glucocorticoids
28 Hormone Antagonists
29 Dermatologic Agents
30 Hormones
31 Hormones, Hormone Substitutes, and Hormone Antagonists
32 Emollients
33 Anti-Inflammatory Agents
34 Antineoplastic Agents, Hormonal
35 Prednisolone acetate
36 Analgesics
37 calcium channel blockers
38 Methylprednisolone acetate
39 Methylprednisolone Hemisuccinate
40 Central Nervous System Depressants
41 Sodium Channel Blockers
42 GABA Agents
43 Gastrointestinal Agents
44 Neuroprotective Agents
45 Neurotransmitter Agents
46 Tranquilizing Agents
47 Analgesics, Non-Narcotic
48 Cytochrome P-450 CYP3A Inducers
49 Diuretics, Potassium Sparing
50 Peripheral Nervous System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
2 Treatment of Hypersensitivity Syndrome (DRESS) With Tegeline® (Human Immunoglobulin) Terminated NCT00505648 Phase 3 Tegeline®
3 Comparison Between Corticosteroid and Topical Steroids in the DRESS Unknown status NCT01987076 Prednisone;Clobetasol
4 Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs Completed NCT02556320 anti-epileptic drug
5 Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions Completed NCT01276314 anti- TNF-a;Prednisolone
6 T Cell Response in Hypersensitivity Syndrome Completed NCT00213447
7 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988
8 An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557

Search NIH Clinical Center for Drug Rash with Eosinophilia and Systemic Symptoms

Genetic Tests for Drug Rash with Eosinophilia and Systemic Symptoms

Anatomical Context for Drug Rash with Eosinophilia and Systemic Symptoms

MalaCards organs/tissues related to Drug Rash with Eosinophilia and Systemic Symptoms:

38
Skin, T Cells, Thyroid, Testes, Liver, Thymus

Publications for Drug Rash with Eosinophilia and Systemic Symptoms

Articles related to Drug Rash with Eosinophilia and Systemic Symptoms:

(show top 50) (show all 88)
# Title Authors Year
1
Drug rash with eosinophilia and systemic symptoms (DRESS) caused by phenytoin. ( 28830901 )
2017
2
Letter to the editor "Drug rash with eosinophilia and systemic symptoms syndrome induced by carbamazepine: Case report". ( 29083557 )
2017
3
Successful use of dabrafenib after the occurrence of drug rash with eosinophilia and systemic symptoms (DRESS) induced by vemurafenib. ( 29296640 )
2017
4
Skin-Homing IL-13-Producing T Cells Expand in the Circulation of Patients with Drug Rash with Eosinophilia and Systemic Symptoms. ( 28601883 )
2017
5
Leukapheresis in the management of drug rash with eosinophilia and systemic symptoms syndrome. ( 27017438 )
2016
6
Reactivation of Skin Lesions After Patch Testing to Investigate Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( 27340118 )
2016
7
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) induced by antituberculous treatment. ( 28994898 )
2016
8
Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS). ( 27374681 )
2016
9
Oxcarbazepine-induced drug rash with eosinophilia and systemic symptoms syndrome presenting as exfoliative dermatitis. ( 27651712 )
2016
10
Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( 27181555 )
2016
11
Cefotaxime-induced drug rash with eosinophilia and systemic symptoms syndrome in a 7-year-old boy. ( 27364942 )
2016
12
Acute tubular necrosis as a part of vancomycin induced drug rash with eosinophilia and systemic symptoms syndrome with coincident postinfectious glomerulonephritis. ( 27186222 )
2016
13
Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study. ( 25630796 )
2015
14
Isoniazid-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Presenting as Acute Eosinophilic Myocarditis. ( 25986261 )
2015
15
Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. ( 26298826 )
2015
16
DRESS Syndrome: Drug Rash with Eosinophilia and Systemic Symptoms. ( 26591154 )
2015
17
Drug Rash with Eosinophilia and Systemic Symptoms to antituberculosis treatment. ( 26895118 )
2015
18
Myocarditis in drug rash with eosinophilia and systemic symptoms. ( 25234569 )
2014
19
HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population. ( 25303297 )
2014
20
Severe recurrence of drug rash with eosinophilia and systemic symptoms syndrome secondary to rifampicin patch testing in a human immunodeficiency virus-infected man. ( 24450829 )
2014
21
Drug rash with eosinophilia and systemic symptoms syndrome induced by chloral hydrate in early childhood. ( 24843805 )
2014
22
Imatinib causing drug rash with eosinophilia and systemic symptoms: A rare cutaneous reaction. ( 25593801 )
2014
23
Ceftriaxone induced drug rash with eosinophilia and systemic symptoms. ( 25114941 )
2014
24
A Case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Induced by Telaprevir Associated with HHV-6 Active Infection. ( 25239077 )
2014
25
Increased ratio of FoxP3+ regulatory T cells/CD3+ T cells in skin lesions in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. ( 24635062 )
2014
26
Pentoxifylline-induced drug rash with eosinophilia and systemic symptoms (DRESS) in a patient with caffeine intolerance. ( 24133560 )
2013
27
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome and hepatitis induced by phenytoin. ( 23829691 )
2013
28
Case report of drug rash with eosinophilia and systemic symptoms demonstrating human herpesvirus-6 reactivation. ( 24016284 )
2013
29
Liver transplantation in a child with acute liver failure resulting from drug rash with eosinophilia and systemic symptoms syndrome. ( 23741237 )
2013
30
Drug rash with eosinophilia and systemic symptoms (DRESS) in patients receiving strontium ranelate. ( 23361875 )
2013
31
A case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) related to rufinamide. ( 24021364 )
2013
32
Cytokine gene expression profiling to help identify a safe antibiotic in a patient with drug rash with eosinophilia and systemic symptoms. ( 24565631 )
2013
33
Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Due to Anti-TB Medication. ( 24479051 )
2013
34
Drug rash with eosinophilia and systemic symptoms syndrome associated with use of phenytoin, divalproex sodium, and phenobarbital. ( 23456403 )
2013
35
Identification of thymus and activation-regulated chemokine (TARC/CCL17) as a potential marker for early indication of disease and prediction of disease activity in drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS). ( 23141052 )
2013
36
Drug rash with eosinophilia and systemic symptoms (DRESS syndrome). ( 22611746 )
2012
37
Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report. ( 22511907 )
2012
38
Drug rash with eosinophilia and systemic symptoms (DRESS) probably induced by cefotaxime: a report of two cases. ( 21817121 )
2012
39
A case of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome complicating airway management. ( 22271506 )
2012
40
The importance of vancomycin in drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. ( 22525393 )
2012
41
Fatal clindamycin-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. ( 23165860 )
2012
42
Allopurinol-induced drug rash with eosinophilia and systemic symptoms mimicking acute generalized exanthematous pustulosis. ( 22901319 )
2012
43
Drug rash with eosinophilia and systemic symptoms: two emergency department cases. ( 22224160 )
2011
44
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by cidofovir. ( 20846239 )
2011
45
Identifying prognostic factors for drug rash with eosinophilia and systemic symptoms (DRESS). ( 21951554 )
2011
46
Drug rash with eosinophilia and systemic symptoms (DRESS) after an unrelated donor BM transplant. ( 21217791 )
2011
47
Case of drug rash with eosinophilia and systemic symptoms induced by zonisamide and reactivation of human herpes virus 7. ( 21998830 )
2011
48
Ceftobiprole associated agranulocytosis after drug rash with eosinophilia and systemic symptoms induced by vancomycin and rifampicin. ( 21219413 )
2011
49
Photodistribution of rash in phenytoin-induced drug rash with eosinophilia and systemic symptoms. ( 21418282 )
2011
50
Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis. ( 22162933 )
2011

Variations for Drug Rash with Eosinophilia and Systemic Symptoms

Expression for Drug Rash with Eosinophilia and Systemic Symptoms

Search GEO for disease gene expression data for Drug Rash with Eosinophilia and Systemic Symptoms.

Pathways for Drug Rash with Eosinophilia and Systemic Symptoms

GO Terms for Drug Rash with Eosinophilia and Systemic Symptoms

Sources for Drug Rash with Eosinophilia and Systemic Symptoms

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