MCID: DRG012
MIFTS: 30

Drug Rash with Eosinophilia and Systemic Symptoms malady

Skin diseases, Immune diseases, Rare diseases categories
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Summaries for Drug Rash with Eosinophilia and Systemic Symptoms

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Wikipedia:65 DRESS syndrome stands for Drug Reaction (or Rash) with Eosinophilia and Systemic Symptoms. The term was... more...

MalaCards based summary: Drug Rash with Eosinophilia and Systemic Symptoms, also known as dress syndrome, is related to eosinophilia and hepatitis, and has symptoms including dry/squaly skin/exfoliation, cutaneous rash and erythema/erythematous lesions/erythroderma/polymorphous erythema. Affiliated tissues include skin, lung and thyroid.

Aliases & Classifications for Drug Rash with Eosinophilia and Systemic Symptoms

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Sources:
48Orphanet, 62UMLS, 63UMLS via Orphanet
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Drug Rash with Eosinophilia and Systemic Symptoms, Aliases & Descriptions:

Name: Drug Rash with Eosinophilia and Systemic Symptoms 48
Dress Syndrome 48 62
 
Drug Reaction Eosinophilic Systemic Syndrome 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
dress syndrome:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

UMLS via Orphanet63 C1142139

Related Diseases for Drug Rash with Eosinophilia and Systemic Symptoms

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Diseases related to Drug Rash with Eosinophilia and Systemic Symptoms via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia11.3
2hepatitis10.6
3acute liver failure10.4
4graft versus host disease10.4
5hepatitis a10.4
6interstitial nephritis10.4
7myocarditis10.4
8pancreatitis10.4
9tuberculosis10.4
10toxic epidermal necrolysis10.4
11septic shock10.4
12nephritis10.4
13acute generalized exanthematous pustulosis10.4
14dysphagia10.2
15autoimmune hepatitis10.0
16cerebritis10.0
17brucellosis10.0
18endocarditis10.0
19purpura10.0
20vasculitis10.0
21chylous ascites10.0
22sepsis10.0

Graphical network of the top 20 diseases related to Drug Rash with Eosinophilia and Systemic Symptoms:



Diseases related to drug rash with eosinophilia and systemic symptoms

Symptoms for Drug Rash with Eosinophilia and Systemic Symptoms

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Symptoms:

48 (show all 31)
  • dry/squaly skin/exfoliation
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • follicular/erythematous/edematous papules/milium
  • negative nikolski's sign
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • lymphadenopathy/polyadenopathies
  • thyroiditis
  • encephalitis
  • severe allergic reaction/atopy
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • angioedema/angioneurotic edema
  • abnormal hepatic enzymes/transaminases
  • lung/pulmonary infiltrates
  • interstitial/restrictive pneumopathy/restrictive respiratory syndrome
  • hyperlymphocytosis
  • pustula/pustulosis
  • enanthema/aphtosa/aphta/leukoplakia
  • hepatitis/icterus/cholestasis
  • acute hepatic failure
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • myocardium anomalies/myocarditis
  • interstitial nephropathy
  • renal failure
  • nephrotic syndrome
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • peripheral neuropathy
  • eosinophils anomalies/hypereosinophilia

HPO human phenotypes related to Drug Rash with Eosinophilia and Systemic Symptoms:

(show all 23)
id Description Frequency HPO Source Accession
1 dry skin hallmark (90%) HP:0000958
2 skin rash hallmark (90%) HP:0000988
3 hypermelanotic macule hallmark (90%) HP:0001034
4 sudden cardiac death hallmark (90%) HP:0001645
5 weight loss hallmark (90%) HP:0001824
6 encephalitis hallmark (90%) HP:0002383
7 lymphadenopathy hallmark (90%) HP:0002716
8 abnormality of temperature regulation hallmark (90%) HP:0004370
9 immunologic hypersensitivity hallmark (90%) HP:0100326
10 thyroiditis hallmark (90%) HP:0100646
11 restrictive lung disease typical (50%) HP:0002091
12 pulmonary infiltrates typical (50%) HP:0002113
13 elevated hepatic transaminases typical (50%) HP:0002910
14 lymphocytosis typical (50%) HP:0100827
15 renal insufficiency occasional (7.5%) HP:0000083
16 nephrotic syndrome occasional (7.5%) HP:0000100
17 abnormality of the oral cavity occasional (7.5%) HP:0000163
18 abnormality of the myocardium occasional (7.5%) HP:0001637
19 abnormality of eosinophils occasional (7.5%) HP:0001879
20 respiratory insufficiency occasional (7.5%) HP:0002093
21 acute hepatic failure occasional (7.5%) HP:0006554
22 peripheral neuropathy occasional (7.5%) HP:0009830
23 pustule occasional (7.5%) HP:0200039

Drugs & Therapeutics for Drug Rash with Eosinophilia and Systemic Symptoms

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Drug clinical trials:

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Genetic Tests for Drug Rash with Eosinophilia and Systemic Symptoms

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Anatomical Context for Drug Rash with Eosinophilia and Systemic Symptoms

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MalaCards organs/tissues related to Drug Rash with Eosinophilia and Systemic Symptoms:

32
Skin, Lung, Thyroid, Liver, Testes, Thymus, T cells

Animal Models for Drug Rash with Eosinophilia and Systemic Symptoms or affiliated genes

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Publications for Drug Rash with Eosinophilia and Systemic Symptoms

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Articles related to Drug Rash with Eosinophilia and Systemic Symptoms:

(show top 50)    (show all 68)
idTitleAuthorsYear
1
Myocarditis in drug rash with eosinophilia and systemic symptoms. (25234569)
2014
2
A Case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Induced by Telaprevir Associated with HHV-6 Active Infection. (25239077)
2014
3
Increased ratio of FoxP3+ regulatory T cells/CD3+ T cells in skin lesions in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. (24635062)
2014
4
Drug rash with eosinophilia and systemic symptoms syndrome induced by chloral hydrate in early childhood. (24843805)
2014
5
Liver transplantation in a child with acute liver failure resulting from drug rash with eosinophilia and systemic symptoms syndrome. (23741237)
2013
6
A case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) related to rufinamide. (24021364)
2013
7
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome and hepatitis induced by phenytoin. (23829691)
2013
8
Cytokine gene expression profiling to help identify a safe antibiotic in a patient with drug rash with eosinophilia and systemic symptoms. (24565631)
2013
9
Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Due to Anti-TB Medication. (24479051)
2013
10
Pentoxifylline-induced drug rash with eosinophilia and systemic symptoms (DRESS) in a patient with caffeine intolerance. (24133560)
2013
11
Case report of drug rash with eosinophilia and systemic symptoms demonstrating human herpesvirus-6 reactivation. (24016284)
2013
12
Drug rash with eosinophilia and systemic symptoms (DRESS syndrome). (22611746)
2012
13
Drug rash with eosinophilia and systemic symptoms (DRESS) probably induced by cefotaxime: a report of two cases. (21817121)
2012
14
A case of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome complicating airway management. (22271506)
2012
15
Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report. (22511907)
2012
16
Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis. (22162933)
2011
17
Case of drug rash with eosinophilia and systemic symptoms induced by zonisamide and reactivation of human herpes virus 7. (21998830)
2011
18
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by cidofovir. (20846239)
2011
19
Ceftobiprole associated agranulocytosis after drug rash with eosinophilia and systemic symptoms induced by vancomycin and rifampicin. (21219413)
2011
20
Photodistribution of rash in phenytoin-induced drug rash with eosinophilia and systemic symptoms. (21418282)
2011
21
First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis. (21098750)
2010
22
Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazine. (20546480)
2010
23
Drug rash with eosinophilia and systemic symptoms due to telaprevir. (20798484)
2010
24
Drug rash with eosinophilia and systemic symptoms (DRESS): changing carbamazepine to phenobarbital controlled epilepsy without the recurrence of DRESS. (20103499)
2010
25
Drug rash with eosinophilia and systemic symptoms syndrome associated with clindamycin. (20843501)
2010
26
Drug rash with eosinophilia and systemic symptoms syndrome induced by sulfasalazine. (19854669)
2010
27
Hypersensitivity to amoxicillin after drug rash with eosinophilia and systemic symptoms (DRESS) to carbamazepine and allopurinol: a possible co-sensitization. (20653681)
2010
28
Antituberculosis drug-induced drug rash with eosinophilia and systemic symptoms syndrome confirmed by patch testing. (21314014)
2010
29
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. (19733945)
2009
30
Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia. (19122478)
2009
31
Severe vancomycin-induced drug rash with eosinophilia and systemic symptoms syndrome imitating septic shock. (19424074)
2009
32
Drug rash with eosinophilia and systemic symptoms after penicillin V administration in a patient with acquired C1 inhibitor acquired deficiency. (19639734)
2009
33
Drug rash with eosinophilia and systemic symptoms and graft-versus-host disease developing sequentially in a patient. (18793307)
2009
34
The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug. (19563993)
2009
35
Drug rash with eosinophilia and systemic symptoms induced by cefotaxime and ampicillin. (18533962)
2008
36
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome induced by celecoxib and anti-tuberculosis drugs. (18583892)
2008
37
Clinicopathological features and prognosis of drug rash with eosinophilia and systemic symptoms: a study of 30 cases in Taiwan. (18627428)
2008
38
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome: suspected association with titanium bioprosthesis. (17873538)
2007
39
Drug rash with eosinophilia and systemic symptoms after ibuprofen intake. (17982931)
2007
40
Drug rash with eosinophilia and systemic symptoms syndrome due to quinine. (18097122)
2007
41
Association of hypogammaglobulinemia with DRESS (Drug Rash with Eosinophilia and Systemic Symptoms). (17229608)
2006
42
Possible drug rash with eosinophilia and systemic symptoms syndrome after exposure to epoetin alfa. (16303911)
2005
43
Drug rash with eosinophilia and systemic symptoms vs toxic epidermal necrolysis: the dilemma of classification. (15896547)
2005
44
Drug rash with eosinophilia and systemic symptoms (DRESS) due to streptomycin. (15040497)
2004
45
Drug rash with eosinophilia and systemic symptoms syndrome and renal toxicity with a nevirapine-containing regimen in a pregnant patient with human immunodeficiency virus. (12738113)
2003
46
Drug rash with eosinophilia and systemic symptoms secondary to phenobarbitone. (12897635)
2003
47
Active human herpesvirus 6 infection in a patient with drug rash with eosinophilia and systemic symptoms. (12839588)
2003
48
Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): an update. (12771485)
2003
49
Drug rash with eosinophilia and systemic symptoms caused by topical application of mercury. (11146363)
2000
50
Drug rash with eosinophilia and systemic symptoms (DRESS syndrome). (10544509)
1999

Variations for Drug Rash with Eosinophilia and Systemic Symptoms

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Expression for genes affiliated with Drug Rash with Eosinophilia and Systemic Symptoms

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Search GEO for disease gene expression data for Drug Rash with Eosinophilia and Systemic Symptoms.

Pathways for genes affiliated with Drug Rash with Eosinophilia and Systemic Symptoms

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Compounds for genes affiliated with Drug Rash with Eosinophilia and Systemic Symptoms

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GO Terms for genes affiliated with Drug Rash with Eosinophilia and Systemic Symptoms

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Products for genes affiliated with Drug Rash with Eosinophilia and Systemic Symptoms

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Sources for Drug Rash with Eosinophilia and Systemic Symptoms

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet