MCID: DRG012
MIFTS: 33

Drug Rash with Eosinophilia and Systemic Symptoms

Categories: Skin diseases, Immune diseases, Rare diseases

Aliases & Classifications for Drug Rash with Eosinophilia and Systemic Symptoms

MalaCards integrated aliases for Drug Rash with Eosinophilia and Systemic Symptoms:

Name: Drug Rash with Eosinophilia and Systemic Symptoms 56
Drug Reaction Eosinophilic Systemic Syndrome 56
Drug Hypersensitivity Syndrome 69
Dress Syndrome 56

Characteristics:

Orphanet epidemiological data:

56
drug rash with eosinophilia and systemic symptoms
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



Summaries for Drug Rash with Eosinophilia and Systemic Symptoms

MalaCards based summary : Drug Rash with Eosinophilia and Systemic Symptoms, also known as drug reaction eosinophilic systemic syndrome, is related to hepatitis and myocarditis, and has symptoms including renal insufficiency, nephrotic syndrome and skin rash. The drugs Dapsone and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Related Diseases for Drug Rash with Eosinophilia and Systemic Symptoms

Diseases related to Drug Rash with Eosinophilia and Systemic Symptoms via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
id Related Disease Score Top Affiliating Genes
1 hepatitis 10.0
2 myocarditis 10.0
3 acute liver failure 9.9
4 glomerulonephritis 9.9
5 interstitial nephritis 9.9
6 hepatitis a 9.9
7 epilepsy 9.9
8 dermatitis 9.9
9 tuberculosis 9.9
10 pancreatitis 9.9
11 encephalitis 9.9
12 exfoliative dermatitis 9.9
13 limbic encephalitis 9.9
14 syndrome of inappropriate antidiuretic hormone 9.9
15 acute generalized exanthematous pustulosis 9.9
16 lymphoma 9.7

Graphical network of the top 20 diseases related to Drug Rash with Eosinophilia and Systemic Symptoms:



Diseases related to Drug Rash with Eosinophilia and Systemic Symptoms

Symptoms & Phenotypes for Drug Rash with Eosinophilia and Systemic Symptoms

Human phenotypes related to Drug Rash with Eosinophilia and Systemic Symptoms:

56 32 (show all 28)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 56 32 occasional (7.5%) Occasional (29-5%) HP:0000083
2 nephrotic syndrome 56 32 occasional (7.5%) Occasional (29-5%) HP:0000100
3 skin rash 56 32 hallmark (90%) Very frequent (99-80%) HP:0000988
4 erythroderma 56 32 hallmark (90%) Very frequent (99-80%) HP:0001019
5 cardiac arrest 56 32 hallmark (90%) Very frequent (99-80%) HP:0001695
6 weight loss 56 32 hallmark (90%) Very frequent (99-80%) HP:0001824
7 eosinophilia 56 32 occasional (7.5%) Occasional (29-5%) HP:0001880
8 fever 56 32 hallmark (90%) Very frequent (99-80%) HP:0001945
9 tubulointerstitial nephritis 56 32 occasional (7.5%) Occasional (29-5%) HP:0001970
10 dyspnea 56 32 occasional (7.5%) Occasional (29-5%) HP:0002094
11 pulmonary infiltrates 56 32 frequent (33%) Frequent (79-30%) HP:0002113
12 encephalitis 56 32 hallmark (90%) Very frequent (99-80%) HP:0002383
13 lymphadenopathy 56 32 hallmark (90%) Very frequent (99-80%) HP:0002716
14 elevated hepatic transaminases 56 32 frequent (33%) Frequent (79-30%) HP:0002910
15 interstitial pneumonitis 56 32 frequent (33%) Frequent (79-30%) HP:0006515
16 acute hepatic failure 56 32 occasional (7.5%) Occasional (29-5%) HP:0006554
17 peripheral neuropathy 56 32 occasional (7.5%) Occasional (29-5%) HP:0009830
18 erythema 56 32 hallmark (90%) Very frequent (99-80%) HP:0010783
19 hepatitis 56 32 occasional (7.5%) Occasional (29-5%) HP:0012115
20 macule 56 32 hallmark (90%) Very frequent (99-80%) HP:0012733
21 cough 56 32 occasional (7.5%) Occasional (29-5%) HP:0012735
22 myocarditis 56 32 occasional (7.5%) Occasional (29-5%) HP:0012819
23 enanthema 56 32 occasional (7.5%) Occasional (29-5%) HP:0030249
24 immunologic hypersensitivity 56 32 hallmark (90%) Very frequent (99-80%) HP:0100326
25 thyroiditis 56 32 hallmark (90%) Very frequent (99-80%) HP:0100646
26 angioedema 56 32 hallmark (90%) Very frequent (99-80%) HP:0100665
27 lymphocytosis 56 32 frequent (33%) Frequent (79-30%) HP:0100827
28 pustule 56 32 occasional (7.5%) Occasional (29-5%) HP:0200039

Drugs & Therapeutics for Drug Rash with Eosinophilia and Systemic Symptoms

Drugs for Drug Rash with Eosinophilia and Systemic Symptoms (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Antimalarials Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Folic Acid Antagonists Phase 4
10 Vitamin B Complex Phase 4
11 Folate Nutraceutical Phase 4
12 Vitamin B9 Nutraceutical Phase 4
13 Antibodies Phase 3
14 Immunoglobulins Phase 3
15
Prednisone Approved, Vet_approved 53-03-2 5865
16
Etanercept Approved, Investigational 185243-69-0
17
Carbamazepine Approved, Investigational 298-46-4 2554
18
Eslicarbazepine acetate Approved 75970-99-9, 236395-14-5 123618
19
Lamotrigine Approved, Investigational 84057-84-1 3878
20
Oxcarbazepine Approved 28721-07-5 34312
21
Valproic Acid Approved, Investigational 99-66-1 3121
22
Saxagliptin Approved 361442-04-8 11243969
23
Petrolatum Approved 8009-03-8
24
Clobetasol Investigational 25122-46-7, 25122-41-2 32798 5311051
25 Anti-Inflammatory Agents
26 Antineoplastic Agents, Hormonal
27 Dermatologic Agents
28 Emollients
29 glucocorticoids
30 Hormone Antagonists
31 Hormones
32 Hormones, Hormone Substitutes, and Hormone Antagonists
33 Analgesics
34 Analgesics, Non-Narcotic
35 Anticonvulsants
36 Antimanic Agents
37 calcium channel blockers
38 Calcium, Dietary
39 Central Nervous System Depressants
40 Cytochrome P-450 CYP3A Inducers
41 Diuretics, Potassium Sparing
42 Excitatory Amino Acid Antagonists
43 Excitatory Amino Acids
44 GABA Agents
45 Neurotransmitter Agents
46 Peripheral Nervous System Agents
47 Psychotropic Drugs
48 Sodium Channel Blockers
49 Tranquilizing Agents
50 Dipeptidyl-Peptidase IV Inhibitors

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
2 Treatment of Hypersensitivity Syndrome (DRESS) With Tegeline® (Human Immunoglobulin) Terminated NCT00505648 Phase 3 Tegeline®
3 Comparison Between Corticosteroid and Topical Steroids in the DRESS Unknown status NCT01987076 Prednisone;Clobetasol
4 Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions Unknown status NCT01276314 anti-TNF a
5 Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs Completed NCT02556320 anti-epileptic drug
6 T Cell Response in Hypersensitivity Syndrome Completed NCT00213447
7 Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments Completed NCT01086319
8 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988
9 An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
10 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342

Search NIH Clinical Center for Drug Rash with Eosinophilia and Systemic Symptoms

Genetic Tests for Drug Rash with Eosinophilia and Systemic Symptoms

Anatomical Context for Drug Rash with Eosinophilia and Systemic Symptoms

MalaCards organs/tissues related to Drug Rash with Eosinophilia and Systemic Symptoms:

39
Skin, Testes, T Cells, Thyroid, Liver, Thymus

Publications for Drug Rash with Eosinophilia and Systemic Symptoms

Articles related to Drug Rash with Eosinophilia and Systemic Symptoms:

(show top 50) (show all 85)
id Title Authors Year
1
Drug rash with eosinophilia and systemic symptoms (DRESS) caused by phenytoin. ( 28830901 )
2017
2
Skin-Homing IL-13-Producing T Cells Expand in the Circulation of Patients with Drug Rash with Eosinophilia and Systemic Symptoms. ( 28601883 )
2017
3
Acute tubular necrosis as a part of vancomycin induced drug rash with eosinophilia and systemic symptoms syndrome with coincident postinfectious glomerulonephritis. ( 27186222 )
2016
4
Cefotaxime-induced drug rash with eosinophilia and systemic symptoms syndrome in a 7-year-old boy. ( 27364942 )
2016
5
Reactivation of Human Herpes Virus-6 in the Renal Tissue of a Patient with Drug-induced Hypersensitivity Syndrome/Drug Rash with Eosinophilia and Systemic Symptoms (DIHS/DRESS). ( 27374681 )
2016
6
Reactivation of Skin Lesions After Patch Testing to Investigate Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( 27340118 )
2016
7
Leukapheresis in the management of drug rash with eosinophilia and systemic symptoms syndrome. ( 27017438 )
2016
8
Oxcarbazepine-induced drug rash with eosinophilia and systemic symptoms syndrome presenting as exfoliative dermatitis. ( 27651712 )
2016
9
Autoimmune Limbic Encephalitis and Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Lamotrigine-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( 27181555 )
2016
10
Isoniazid-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Presenting as Acute Eosinophilic Myocarditis. ( 25986261 )
2015
11
Drug Rash with Eosinophilia and Systemic Symptoms to antituberculosis treatment. ( 26895118 )
2015
12
Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. ( 26298826 )
2015
13
DRESS Syndrome: Drug Rash with Eosinophilia and Systemic Symptoms. ( 26591154 )
2015
14
Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study. ( 25630796 )
2015
15
Myocarditis in drug rash with eosinophilia and systemic symptoms. ( 25234569 )
2014
16
Imatinib causing drug rash with eosinophilia and systemic symptoms: A rare cutaneous reaction. ( 25593801 )
2014
17
HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population. ( 25303297 )
2014
18
Ceftriaxone induced drug rash with eosinophilia and systemic symptoms. ( 25114941 )
2014
19
Increased ratio of FoxP3+ regulatory T cells/CD3+ T cells in skin lesions in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. ( 24635062 )
2014
20
Drug rash with eosinophilia and systemic symptoms syndrome induced by chloral hydrate in early childhood. ( 24843805 )
2014
21
Severe recurrence of drug rash with eosinophilia and systemic symptoms syndrome secondary to rifampicin patch testing in a human immunodeficiency virus-infected man. ( 24450829 )
2014
22
A Case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Induced by Telaprevir Associated with HHV-6 Active Infection. ( 25239077 )
2014
23
Drug rash with eosinophilia and systemic symptoms (DRESS) in patients receiving strontium ranelate. ( 23361875 )
2013
24
Drug rash with eosinophilia and systemic symptoms syndrome associated with use of phenytoin, divalproex sodium, and phenobarbital. ( 23456403 )
2013
25
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome and hepatitis induced by phenytoin. ( 23829691 )
2013
26
Identification of thymus and activation-regulated chemokine (TARC/CCL17) as a potential marker for early indication of disease and prediction of disease activity in drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS). ( 23141052 )
2013
27
Case report of drug rash with eosinophilia and systemic symptoms demonstrating human herpesvirus-6 reactivation. ( 24016284 )
2013
28
Pentoxifylline-induced drug rash with eosinophilia and systemic symptoms (DRESS) in a patient with caffeine intolerance. ( 24133560 )
2013
29
Liver transplantation in a child with acute liver failure resulting from drug rash with eosinophilia and systemic symptoms syndrome. ( 23741237 )
2013
30
A case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) related to rufinamide. ( 24021364 )
2013
31
Drug Rash with Eosinophilia and Systemic Symptoms Syndrome Due to Anti-TB Medication. ( 24479051 )
2013
32
Cytokine gene expression profiling to help identify a safe antibiotic in a patient with drug rash with eosinophilia and systemic symptoms. ( 24565631 )
2013
33
Fatal clindamycin-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. ( 23165860 )
2012
34
Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report. ( 22511907 )
2012
35
The importance of vancomycin in drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. ( 22525393 )
2012
36
A case of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome complicating airway management. ( 22271506 )
2012
37
Allopurinol-induced drug rash with eosinophilia and systemic symptoms mimicking acute generalized exanthematous pustulosis. ( 22901319 )
2012
38
Drug rash with eosinophilia and systemic symptoms (DRESS syndrome). ( 22611746 )
2012
39
Drug rash with eosinophilia and systemic symptoms (DRESS) probably induced by cefotaxime: a report of two cases. ( 21817121 )
2012
40
Photodistribution of rash in phenytoin-induced drug rash with eosinophilia and systemic symptoms. ( 21418282 )
2011
41
Identifying prognostic factors for drug rash with eosinophilia and systemic symptoms (DRESS). ( 21951554 )
2011
42
Case of drug rash with eosinophilia and systemic symptoms induced by zonisamide and reactivation of human herpes virus 7. ( 21998830 )
2011
43
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by cidofovir. ( 20846239 )
2011
44
Drug rash with eosinophilia and systemic symptoms: two emergency department cases. ( 22224160 )
2011
45
Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis. ( 22162933 )
2011
46
Drug rash with eosinophilia and systemic symptoms (DRESS) after an unrelated donor BM transplant. ( 21217791 )
2011
47
Ceftobiprole associated agranulocytosis after drug rash with eosinophilia and systemic symptoms induced by vancomycin and rifampicin. ( 21219413 )
2011
48
Hypersensitivity to amoxicillin after drug rash with eosinophilia and systemic symptoms (DRESS) to carbamazepine and allopurinol: a possible co-sensitization. ( 20653681 )
2010
49
Penicillin V-induced drug rash with eosinophilia and systemic symptoms. ( 21702250 )
2010
50
Comparison of the causes and clinical features of drug rash with eosinophilia and systemic symptoms and stevens-johnson syndrome. ( 20358026 )
2010

Variations for Drug Rash with Eosinophilia and Systemic Symptoms

Expression for Drug Rash with Eosinophilia and Systemic Symptoms

Search GEO for disease gene expression data for Drug Rash with Eosinophilia and Systemic Symptoms.

Pathways for Drug Rash with Eosinophilia and Systemic Symptoms

GO Terms for Drug Rash with Eosinophilia and Systemic Symptoms

Sources for Drug Rash with Eosinophilia and Systemic Symptoms

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