MCID: DRY001
MIFTS: 49

Dry Eye Syndrome malady

Summaries for Dry Eye Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoconjunctivitis sicca (KCS), also called keratitis sicca,xerophthalmia or dry eye syndrome (DES) is... more...

MalaCards: Dry Eye Syndrome, also known as dry eye syndromes, is related to keratoconjunctivitis sicca and arthritis. An important gene associated with Dry Eye Syndrome is AQP5 (aquaporin 5), and among its related pathways are Gastric acid secretion and O-linked glycosylation of mucins. The drugs sodium chloride and sodium chloride granules and the compounds estrogen and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and salivary gland.

Aliases & Classifications for Dry Eye Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

dry eye syndrome 8 10
dry eye syndromes 44 60
tear film insufficiency 8


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Disease Ontology8 DOID:10140
ICD9CM27 375.15
NCIt39 C34553
MeSH34 D015352

Related Diseases for Dry Eye Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Dry Eye Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis sicca30.4LTF, HSPG2
2arthritis30.3LYZ, LTF
3rheumatoid arthritis30.3LGALS1, FGF7, LTF, NTF3, HSPG2
4blepharitis30.0LACRT, LTF
5crohn's disease30.0LYZ, LTF
6sjogren's syndrome30.0HSPG2, SSB, LTF, MUC5AC, AQP5
7eye disease10.4
8allergic conjunctivitis10.3
9conjunctivitis10.3
10post-traumatic stress disorder10.1
11adult syndrome10.1
12cataract10.1
13diabetic retinopathy10.1
14glaucoma10.1
15keratitis10.1
16myopia10.1
17superficial keratitis10.1
18thyroiditis10.1
19gingivitis10.0LTF
20prostatitis10.0LTF
21pulmonary disease, chronic obstructive10.0MUC5B
22dental caries10.0LTF
23gingival overgrowth10.0FGF7
24biliary papillomatosis10.0MUC5B
25influenza10.0LTF
26sinusitis10.0MUC5B
27chorioamnionitis10.0LTF
28allergic rhinitis10.0NGF
29amyloidosis10.0LYZ
30pancreatitis10.0HSPG2, LTF
31skin disease10.0LYZ
32endometriosis10.0HGF
33phaeochromocytoma10.0NGF
34dacryoadenitis10.0HSPG2
35sarcoidosis10.0LYZ
36meningitis10.0LYZ, GDNF
37polyneuropathy10.0HSPG2, GDNF
38diabetic autonomic neuropathy10.0NGF
39irritable bowel syndrome10.0LTF
40periodontal disease10.0LYZ, LTF
41hepatitis10.0HGF, HSPG2
42chordoma10.0MUC1
43thyroid cancer10.0LGALS1, HSPG2
44eosinophilia10.0NGF, HSPG2
45malignant glioma10.0HGF, NTF3
46pulmonary fibrosis10.0HGF, FGF7
47neuroblastoma10.0NGF
48otitis media10.0LTF, MUC5AC, MUC5B
49neuroaxonal dystrophy10.0NTF3, NGF
50herpes simplex10.0NTF3, GDNF

Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to dry eye syndrome

Clinical Features for Dry Eye Syndrome

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Drugs & Therapeutics for Dry Eye Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dry Eye Syndrome

Drug clinical trials:

Search ClinicalTrials for Dry Eye Syndrome

Search NIH Clinical Center for Dry Eye Syndrome

Search CenterWatch for Dry Eye Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Dry Eye Syndrome

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Anatomical Context for Dry Eye Syndrome

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32MalaCards
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MalaCards organs/tissues related to Dry Eye Syndrome:

32
Eye, Testes, Salivary gland, Thyroid, Ovary, Bone, Bone marrow

Animal Models for Dry Eye Syndrome or affiliated genes

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Publications for Dry Eye Syndrome

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50PubMed
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Articles related to Dry Eye Syndrome:

(show top 50)    (show all 185)
idTitleAuthorsYear
1
Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. (23740519)
2013
2
Comparison of two methods for composite score generation in dry eye syndrome. (23942971)
2013
3
Clinical correlations of dry eye syndrome and allergic conjunctivitis in Korean children. (23316947)
2013
4
Effects of dietary supplementation with fish oil on dry eye syndrome subjects: randomized controlled trial. (24190233)
2013
5
Efficacy of cyclosporine 0.05% eye drops in Stevens Johnson syndrome with chronic dry eye. (23289903)
2013
6
Hormones and dry eye syndrome: an update on what we do and don't know. (23680756)
2013
7
Prevalence and risk factors associated with dry eye syndrome among senior high school students in a county of Shandong Province, China. (22650150)
2012
8
Minor salivary glands and labial mucous membrane graft in the treatment of severe symblepharon and dry eye in patients with Stevens-Johnson syndrome. (21527414)
2012
9
Depression, post-traumatic stress disorder, and dry eye syndrome: a study utilizing the national United States Veterans Affairs administrative database. (22541654)
2012
10
Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome. (21461217)
2011
11
Dry eye syndrome. (22454735)
2011
12
Effectiveness of polyethylene covers versus carbomer drops (Viscotears) to prevent dry eye syndrome in the critically ill. (21414053)
2011
13
Prevalence and risk factors of dry eye syndrome in a United States veterans affairs population. (21684522)
2011
14
Dry eye syndrome: an update in office management. (21944160)
2011
15
Labial salivary gland transplantation for severe dry eye due to chemical burns and Stevens-Johnson syndrome. (20489543)
2010
16
Effectiveness of hormone therapy for treating dry eye syndrome in postmenopausal women: a randomized trial. (20572368)
2010
17
Two dimensional electrophoretic analysis of human tears: collection method in dry eye syndrome. (20882555)
2010
18
Punctal occlusion for dry eye syndrome. (20824852)
2010
19
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. (19850844)
2010
20
Dry eye syndrome-related quality of life in glaucoma patients. (19551671)
2009
21
Advancements in anti-inflammatory therapy for dry eye syndrome. (19801339)
2009
22
Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. (19705875)
2009
23
Antioxidants intake and dry eye syndrome: a crossover, placebo-controlled, randomized trial. (19396775)
2009
24
Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. (18513455)
2008
25
Dry eye syndrome (DES) and watering eyes. (19057472)
2008
26
Impact of floppy eyelid syndrome in ocular surface and dry eye disease. (18772717)
2008
27
The presence of dry eye syndrome and corneal complications in patients with rheumatoid arthritis and its association with -174 gene polymorphism for interleukin 6]. (18419107)
2008
28
Dry-eye syndrome after allogeneic stem-cell transplantation in children. (18093259)
2008
29
Impact of dry eye syndrome on vision-related quality of life. (17317388)
2007
30
Increased evaporative rates in laboratory testing conditions simulating airplane cabin relative humidity: an important factor for dry eye syndrome. (17630623)
2007
31
Dry eye syndrome in diabetic children. (18050110)
2007
32
Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. (16633024)
2006
33
Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome. (16682594)
2006
34
Increasing importance of dry eye syndrome and the ideal artificial tear: consensus views from a roundtable discussion. (17076975)
2006
35
Efficacy and safety of 0.18% sodium hyaluronate in patients with moderate dry eye syndrome and superficial keratitis. (15965673)
2005
36
Ocular allergy and dry eye syndrome. (15349042)
2004
37
Surgical treatment of dry eye syndrome: conjunctival graft of the minor salivary gland. (14704553)
2004
38
Dry eye syndrome increases with age. (15132102)
2004
39
Prevalence of dry eye syndrome among US women. (12888056)
2003
40
Medications for dry eye syndrome: a drug-therapy review. (14723111)
2003
41
The significance of salivary gland ultrasonography in the diagnosis of dry eye syndrome. (12614055)
2002
42
Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. (11879137)
2002
43
Efficacy and tolerability outcomes after punctal occlusion with silicone plugs in dry eye syndrome. (11678136)
2001
44
Dry eye syndrome. (10366066)
1999
45
Argon laser punctal therapy versus thermal cautery for the treatment of aqueous deficiency dry eye syndrome. (9885751)
1998
46
Efficacy and safety of 0.3% carbomer gel compared to placebo in patients with moderate-to-severe dry eye syndrome. (9307633)
1997
47
A subjective approach to the treatment of dry eye syndrome. (8030537)
1994
48
Identification of sigma receptors in lacrimocytes and their therapeutic implication in dry eye syndrome. (8030466)
1994
49
Dry eye syndrome in Pakistani community. (2113958)
1990
50
Influence of artificial tears on corneal epithelium in dry-eye syndrome. (2721982)
1989

Genetic Variations for Dry Eye Syndrome

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Expression for genes affiliated with Dry Eye Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dry Eye Syndrome

Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for genes affiliated with Dry Eye Syndrome

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29KEGG, 53Reactome
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Pathways related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2LYZ, AQP5
2
Hide members
9.7MUC4, MUC1, MUC5B, MUC5AC

Compounds for genes affiliated with Dry Eye Syndrome

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Dry Eye Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6AQP5, LTF
2hydrocortisone44 2 59 1113.4MUC1, LTF
3periodate4410.3LTF, MUC5AC, MUC1
4suramin44 28 1112.3P2RY2, FGF7
5c2ceramide4410.1NGF, HGF, LTF, HSPG2
6k252a4410.1HGF, NGF, NTF3
7capsaicin44 2811.0HSPG2, HGF, LTF, NGF, GDNF
8ganglioside4410.0NTF3, LGALS1, GDNF, NGF
9serine4410.0FGF7, GDNF, MUC5AC, LTF
10nmda44 2810.8GDNF, NTF3, HGF, HSPG2, NGF
11phosphatidylcholine449.8FGF7, HSPG2, LTF, NGF, MUC5AC
12norepinephrine44 11 2411.8LTF, HGF, NTF3, NGF, GDNF
13hyaluronic acid44 2410.8LCN1, FGF7, MUC1, LTF, HGF
14indomethacin44 59 28 1112.8NGF, LTF, HGF, LGALS1, HSPG2
15dmso449.8LGALS1, HGF, HSPG2, MUC5AC, MUC1
16choline44 11 2411.8NGF, GDNF, HSPG2, NTF3
17ethanol44 49 11 2412.8GDNF, MUC1, NTF3, HGF, MUC5AC
18bromodeoxyuridine449.7NTF3, HGF, FGF7, GDNF
1912-o-tetradecanoylphorbol 13-acetate449.7HGF, NTF3, NGF, MUC1, FGF7
205fluorouracil449.7MUC5AC, NGF, HGF, MUC1, FGF7
21ly294002449.7NGF, HSPG2, GDNF, HGF, NTF3
22forskolin44 49 1111.7FGF7, GDNF, MUC1, NGF, NTF3, HSPG2
23agar449.7LGALS1, MUC1, HGF, NTF3, FGF7
24genistein44 28 59 2 11 2414.7HGF, NGF, FGF7, HSPG2, NTF3, GDNF
25acetylcholine44 49 28 11 2413.7NTF3, FGF7, HSPG2, NGF, GDNF
26heparin44 28 11 2412.7LGALS1, GDNF, FGF7, LTF, NTF3, HSPG2
27inositol449.7HSPG2, P2RY2, HGF, NTF3
28paraffin449.6HGF, LTF, NTF3, MUC5AC, MUC1, LGALS1
29pd 98,059449.6FGF7, GDNF, MUC5AC, NGF, HGF, HSPG2
30creatinine449.6HGF, GDNF, LCN1, LTF, NGF, MUC1
31aspartate449.6HGF, LCN1, FGF7, GDNF, NTF3, LTF
32wortmannin449.6GDNF, FGF7, NTF3, NGF, HGF, HSPG2
33glutamine449.5LGALS1, FGF7, NGF, LTF, HGF, HSPG2
34histamine44 28 2411.5FGF7, HSPG2, MUC5AC, NTF3, LTF, NGF
35actinomycin d449.5FGF7, GDNF, MUC1, NGF, LTF, NTF3
36heparan sulfate44 2410.5FGF7, LGALS1, GDNF, NTF3, HGF, HSPG2
37oxygen44 2410.5P2RY2, HGF, MUC1, GDNF, FGF7, LGALS1
38polysaccharide449.5HGF, LTF, NGF, MUC5AC, MUC1, LGALS1
39matrigel449.4MUC1, FGF7, MUC4, HGF, NTF3, NGF
40adenylate449.4P2RY2, LTF, HGF, FGF7, GDNF, NGF
41vegf449.4LTF, GDNF, FGF7, MUC1, NGF, HSPG2
42carbohydrates449.3MUC5AC, MUC1, LGALS1, LTF
43glucose449.2MUC5AC, LGALS1, P2RY2, GDNF, NTF3, MUC1
44atp44 2810.0MUC5AC, GDNF, P2RY2, SSB, HGF, FGF7
45retinoic acid44 2410.0HGF, NTF3, MUC4, MUC1, LTF, NGF
46phosphatidylinositol449.0MUC5AC, LGALS8, P2RY2, FGF7, GDNF, NTF3
47cysteine448.9GDNF, FGF7, LCN1, MUC1, MUC5AC, NGF
48dexamethasone44 49 28 1111.9MUC5AC, HSPG2, HGF, LTF, NGF, MUC1
49tyrosine448.4P2RY2, NGF, HSPG2, NTF3, LACRT, LGALS1
50calcium44 49 11 2411.2LCN1, NTF3, HSPG2, HGF, NGF, LGALS1

GO Terms for genes affiliated with Dry Eye Syndrome

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16Gene Ontology
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Cellular components related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.2HSPG2, NGF, MUC5AC, MUC5B, MUC1, MUC4
2extracellular spaceGO:0056159.0HSPG2, HGF, PRR4, NGF, LGALS1, LGALS8
3extracellular regionGO:0055767.8LYZ, HSPG2, HGF, LCN1, NTF3, LTF

Biological processes related to Dry Eye Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1plasma cell differentiationGO:00231710.0LGALS1, LGALS8
2negative regulation of neuron apoptotic processGO:0435249.9GDNF, NGF, NTF3
3positive chemotaxisGO:0509189.9FGF7, NTF3, HGF
4regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.9FGF7, HGF
5O-glycan processingGO:0162669.9MUC4, MUC1, MUC5B, MUC5AC
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7HGF, NTF3, FGF7, LACRT
7post-translational protein modificationGO:0436879.4MUC5AC, MUC5B, MUC1, MUC4

Molecular functions related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.9MUC5AC, MUC5B, MUC4
2chemoattractant activityGO:0420569.5NTF3, FGF7, HGF
3growth factor activityGO:0080839.1NGF, LACRT, FGF7, GDNF, HGF, NTF3

Products for genes affiliated with Dry Eye Syndrome

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  • Antibodies
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Sources for Dry Eye Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet