Aliases & Classifications for Dry Eye Syndrome

Aliases & Descriptions for Dry Eye Syndrome:

Name: Dry Eye Syndrome 12 14
Dry Eye Syndromes 52 42 69
Tear Film Insufficiency 12
Xerophthalmia 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10140
ICD10 33 H04.12
MeSH 42 D015352
NCIt 47 C34553
UMLS 69 C0013238

Summaries for Dry Eye Syndrome

MalaCards based summary : Dry Eye Syndrome, also known as dry eye syndromes, is related to neuropathy and keratoconjunctivitis sicca, and has symptoms including dryness of eye and dacryops. An important gene associated with Dry Eye Syndrome is AQP5 (Aquaporin 5), and among its related pathways/superpathways are Innate Immune System and HIV Life Cycle. The drugs Cyclosporine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and liver, and related phenotypes are digestive/alimentary and muscle

Wikipedia : 71 Dry eye syndrome (DES), also known as keratoconjunctivitis sicca (KCS), is the condition of having dry... more...

Related Diseases for Dry Eye Syndrome

Diseases related to Dry Eye Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Related Disease Score Top Affiliating Genes
1 neuropathy 29.8 EGF IL6 TNF
2 keratoconjunctivitis sicca 11.8
3 sjogren's syndrome 11.3
4 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
5 degenerative disc disease 10.3 HGF IL6 TNF
6 tinea capitis 10.2 IL6 NGF TNF
7 anal paget's disease 10.2 FGF2 IL6 TNF
8 bipolar i disorder 10.2 FGF2 IL6 TNF
9 orthostatic proteinuria 10.2 IL6 MUC1 TNF
10 measles 10.2 GDNF IL6 TNF
11 benign idiopathic neonatal seizures 10.2 FGF2 LTF TNF
12 uterine corpus dissecting leiomyoma 10.2 EGF IL6 NGF
13 stenosis of lacrimal sac 10.2 IL6 LTF TNF
14 gastroduodenal crohn's disease 10.2 GDNF NGF TNF
15 paranasal sinus sarcoma 10.2 HGF IL6 TNF
16 early yaws 10.2 GDNF IL6 NGF
17 neovascular glaucoma 10.2 EGF IL6 NGF TNF
18 choanal atresia, bilateral 10.2 IL6 LCN1 TNF
19 oppositional defiant disorder 10.1 FGF2 HGF IL6 TNF
20 nasal cavity cancer 10.1 EGF FGF2 HGF TNF
21 optic nerve hypoplasia 10.1 FGF2 IL6 TNF
22 connective tissue cancer 10.1 FGF2 GDNF NGF
23 igg4-related dacryoadenitis and sialadenitis 10.1 FGF7 HGF
24 substance-induced psychosis 10.1 GDNF IL6 NGF TNF
25 growth hormone insensitivity, partial 10.1 AQP5 HSPG2 LTF
26 pancreatic signet ring cell adenocarcinoma 10.1 HSPG2 IL6 TNF
27 splenic marginal zone lymphoma 10.0 ARG1 GDNF IL6 TNF
28 hypoparathyroidism-retardation-dysmorphism syndrome 10.0 HSPG2 IL6 LTF TNF
29 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.0 HSPG2 IL6 LTF TNF
30 lacrimal gland mucoepidermoid carcinoma 10.0 MUC1 MUC5AC
31 allergic conjunctivitis 10.0
32 conjunctivitis 10.0
33 aortic aneurysm, familial thoracic 6 10.0 FGF2 FGF7 HGF MUC1 TNF
34 mikulicz disease 9.9 HSPG2 IL6 LTF NGF TNF
35 nail disorder, nonsyndromic congenital, 3, 9.9 EGF IL6 MUC1 MUC4 TNF
36 laryngeal mucoepidermoid carcinoma 9.9 MUC1 MUC4 MUC5AC
37 fibular collateral ligament bursitis 9.9 MUC1 MUC4 MUC5AC
38 rheumatoid arthritis 9.9
39 arthritis 9.9
40 cataract 9.9
41 thymus mucoepidermoid carcinoma 9.9 MUC1 MUC4 MUC5AC
42 refractory plasma cell neoplasm 9.9 MUC1 MUC4 MUC5AC
43 brachydactyly, type b1 9.9 MUC1 MUC4 MUC5AC
44 lymphedema 9.9 MUC1 MUC4 MUC5AC
45 nephropathy with pretibial epidermolysis bullosa and deafness 9.9 IL6 MUC5AC TNF
46 membranoproliferative glomerulonephritis 9.9 IL6 LTF MUC1 MUC5AC TNF
47 hematopoietic stem cell transplantation 9.8
48 thyroiditis 9.8
49 keratitis 9.8
50 odontotrichoungual-digital-palmar syndrome 9.8 MUC1 MUC4 MUC5AC

Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to Dry Eye Syndrome

Symptoms & Phenotypes for Dry Eye Syndrome

UMLS symptoms related to Dry Eye Syndrome:


dryness of eye, dacryops

MGI Mouse Phenotypes related to Dry Eye Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 AQP5 EGF GDNF HSPG2 IL6 MUC5AC
2 muscle MP:0005369 9.56 AQP5 FGF2 GDNF HSPG2 IL6 NGF
3 vision/eye MP:0005391 9.28 AQP5 EGF FGF2 FGF7 HSPG2 IL6

Drugs & Therapeutics for Dry Eye Syndrome

Drugs for Dry Eye Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 312)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
4
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 299-42-3 9294
5
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 90-82-4 7028
6
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
7
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
8
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
9
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
10
Calcium carbonate Approved Phase 4 471-34-1
11
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
12
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
13
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 9004-61-9 53477741 24759
14
Glycerol Approved, Experimental Phase 4,Phase 2,Phase 3 56-81-5 753
15
Loteprednol Approved Phase 4,Phase 3,Phase 2 82034-46-6, 129260-79-3 444025 9865442
16
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
17
Ethanol Approved Phase 4,Phase 2 64-17-5 702
18
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
19
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
20
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
21
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
22
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
23
Ofloxacin Approved Phase 4 82419-36-1 4583
24
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
25
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
26
Dorzolamide Approved Phase 4 120279-96-1 3154 5284549
27
Timolol Approved Phase 4,Phase 3 26839-75-8 33624 5478
28
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
29
Travoprost Approved Phase 4 157283-68-6 5282226
30
Pilocarpine Approved Phase 4 54-71-7, 92-13-7 5910
31
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
32
Sulfacetamide Approved Phase 4 144-80-9 5320
33
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
34
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
35
Tobramycin Approved, Investigational Phase 4,Phase 1 32986-56-4 5496 36294
36
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
37
Lymecycline Approved Phase 4 992-21-2 5280963
38
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
39
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
40
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
41
Dehydroepiandrosterone Approved, Nutraceutical Phase 4,Phase 2 53-43-0 9860744
42
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
43 tannic acid Approved, Nutraceutical Phase 4
44
Bromfenac Approved July 1997 Phase 4,Phase 3,Phase 2 91714-94-2 60726
45
Maleic acid Experimental Phase 4 110-16-7 444266
46 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Calcineurin Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
50 Carboxymethylcellulose Sodium Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 688)
id Name Status NCT ID Phase
1 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4
2 A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome Unknown status NCT00344721 Phase 4
3 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
4 Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms Unknown status NCT01382810 Phase 4
5 Comparison of Efficacy, Safety and Anti-Inflammatory Effect Between Topical 0.05%Cyclosporine A Emulsion and REFRESH® in Patients With Moderate to Severe Dry Eyes Unknown status NCT00704275 Phase 4
6 Efficacy of FreshKote and Systane for the Treatment of Dry Eye and Improvement of Osmolarity Unknown status NCT01386073 Phase 4
7 Tear Osmolarity Over Time With Artificial Tears Unknown status NCT01227226 Phase 4
8 Patient Satisfaction and Tear Osmolarity With the Use of Blink Tears, Blink Gel Tears and Systane Balance Unknown status NCT01589640 Phase 4
9 Lipids of the Human Tear Film and Their Effect on Tear Stability Unknown status NCT00803452 Phase 4
10 A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis Unknown status NCT01533480 Phase 4
11 Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue Unknown status NCT00543166 Phase 4
12 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome Unknown status NCT02370550 Phase 4
13 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
14 Influence of Lachrymal Substitutes on Tear Film Thickness in Patients With Moderate Dry Eye Syndrome Completed NCT01864330 Phase 4
15 Efficacy and Safety of a Treatment for Dry Eye Syndrome: Thealoz Completed NCT01742884 Phase 4
16 Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy Completed NCT00349440 Phase 4
17 Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITE™) Versus 0.5% Carboxymethylcellulose in the Treatment of Dry Eye Completed NCT00386646 Phase 4
18 Influence of Lachrymal Substitute Gels on Tear Film Thickness in Patients With Moderate to Severe Dry Eye Syndrome Completed NCT02585453 Phase 4
19 A Phase 4 Study Investigating the Efficacy of Retaine™ in Managing Signs and Symptoms Associated With Dry Eye Syndrome Completed NCT02139033 Phase 4
20 TearLab Refractive Surgery Dry Eye Study Completed NCT01176045 Phase 4
21 A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN) Completed NCT02014922 Phase 4
22 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK). Completed NCT00620893 Phase 4
23 Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye Completed NCT03183089 Phase 4
24 Kynex Versus Refresh Plus Study in Subject With Dry Eye Completed NCT00809198 Phase 4
25 The Utility of in Vivo Confocal Microscopy to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With Dry Eye Disease Completed NCT02120079 Phase 4
26 Efficacy of Optive Versus Systane Concomitant With Restasis (Cyclosporine A) for the Treatment of Dry Eye Symptoms Completed NCT00399061 Phase 4
27 The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye Completed NCT01268735 Phase 4
28 Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease Completed NCT00567177 Phase 4
29 Comparison of Autologous Serum Versus Preservative Free Artificial Tear Completed NCT02752763 Phase 4
30 Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye Completed NCT00987727 Phase 4
31 A Prospective, Randomized, Double-Masked, Single Center, Clinical Comparison of the Use of Systane Ultra in the Management of Dry Eyes in Bilateral Eyes Completed NCT00781092 Phase 4
32 Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops Completed NCT01850979 Phase 4
33 Evaluate Artificial Tear Efficacy in Moderate to Severe Dry Eye Completed NCT00724412 Phase 4
34 Comparison of Systane Free vs. Saline in the Treatment of Dry Eye Completed NCT00388791 Phase 4
35 Safety and Efficacy of Optive in Contact Lens Wearers With Dry Eyes Completed NCT00469573 Phase 4
36 A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye Completed NCT02951910 Phase 4
37 Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients Completed NCT01203540 Phase 4
38 Efficacy and Safety of a New Multi-dose Lubricant Eye Drop Concomitant With Restasis® (Cyclosporine A) for the Treatment of Dry Eye Symptoms Completed NCT00405457 Phase 4
39 A Clinical Evaluation Pilot Study of the Efficacy of Blink® Tears Lubricant Eye Drops for the Relief of Dry Eye Symptoms Following Implantation of Tecnis® Multifocal Introcular Lens Completed NCT01061268 Phase 4
40 Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis Completed NCT00407043 Phase 4
41 Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye Completed NCT01488396 Phase 4
42 Efficacy Study of a New Eyedrop on Silicone Hydrogel Contact Lens Wearers With Dry Eye Complaints Completed NCT01543061 Phase 4
43 Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra) Completed NCT02985827 Phase 4
44 Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms Completed NCT00761202 Phase 4
45 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality Completed NCT00622037 Phase 4
46 Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms Completed NCT00938704 Phase 4
47 Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease Completed NCT02004067 Phase 4
48 Pilot Study on the Use of Artificial Tears to Treat Dry Eye in Glaucoma Patients Completed NCT01682460 Phase 4
49 Efficacy of Systane Ultra in Post Menopausal Women With Dry Eye Completed NCT01105910 Phase 4
50 A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye Completed NCT02117687 Phase 4

Search NIH Clinical Center for Dry Eye Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: dry eye syndromes

Genetic Tests for Dry Eye Syndrome

Anatomical Context for Dry Eye Syndrome

MalaCards organs/tissues related to Dry Eye Syndrome:

39
Eye, Testes, Liver, Thyroid, Salivary Gland, Bone, Bone Marrow

Publications for Dry Eye Syndrome

Articles related to Dry Eye Syndrome:

(show top 50) (show all 247)
id Title Authors Year
1
Tear Fluid Protein Changes in Dry Eye Syndrome Associated with Rheumatoid Arthritis: A Proteomic Approach. ( 27789276 )
2017
2
Automated Measurement of Tear Film Dynamics and Lipid Layer Thickness for Assessment of Non-SjAPgren Dry Eye Syndrome With Meibomian Gland Dysfunction. ( 28060064 )
2017
3
Vitamin D Supplementation for Patients with Dry Eye Syndrome Refractory to Conventional Treatment. ( 27698364 )
2016
4
The Association between Symptoms of Dry Eye Syndrome and Metabolic Outcome in a General Population in Korea. ( 27366012 )
2016
5
Solvent/Detergent Virally Inactivated Serum Eye Drops Restore Healthy Ocular Epithelium in a Rabbit Model of Dry-Eye Syndrome. ( 27100624 )
2016
6
Proper balance of omega-3 and omega-6 fatty acid supplements with topical cyclosporine attenuated contact lens-related dry eye syndrome. ( 27766505 )
2016
7
Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome. ( 27874256 )
2016
8
Synergistic Effect of Artificial Tears Containing Epigallocatechin Gallate and Hyaluronic Acid for the Treatment of Rabbits with Dry Eye Syndrome. ( 27336157 )
2016
9
A Comprehensive Review of Sex Disparities in Symptoms, Pathophysiology, and Epidemiology of Dry Eye Syndrome. ( 27101252 )
2016
10
Efficacy of a New Ocular Surface Modulator in Restoring Epithelial Changes in an In Vitro Model of Dry Eye Syndrome. ( 27163340 )
2016
11
Low Serum 25-Hydroxyvitamin D Levels Are Associated with Dry Eye Syndrome. ( 26807908 )
2016
12
Prevalence of dry eye syndrome in residents of surgical specialties. ( 27422541 )
2016
13
Quality, safety and sustained therapeutic efficacy of blood-derived serum eye drops to treat dry eye syndrome: R&D road map for future progress. ( 26818750 )
2016
14
Analysis of Factors Associated With the Tear Film Lipid Layer Thickness in Normal Eyes and Patients With Dry Eye Syndrome. ( 27537256 )
2016
15
Dry Eye Syndrome Risks in Patients With Fibromyalgia: A National Retrospective Cohort Study. ( 26825913 )
2016
16
An eye on nutrition: The role of vitamins, essential fatty acids, and antioxidants in age-related macular degeneration, dry eye syndrome, and cataract. ( 26903189 )
2016
17
Dry Eye Syndrome in Patients with Diabetes Mellitus: Prevalence, Etiology, and Clinical Characteristics. ( 27213053 )
2016
18
Severity of dry eye syndrome is related to anti-dsDNA autoantibody in systemic lupus erythematosus patients without secondary Sjogren syndrome: A cross-sectional analysis. ( 27428227 )
2016
19
Examining the relationship between hormone therapy and dry-eye syndrome in postmenopausal women: a cross-sectional comparison study. ( 27003590 )
2016
20
Understanding Symptoms and Quality of Life inA Patients With Dry Eye Syndrome. ( 27224876 )
2016
21
A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome. ( 27445067 )
2016
22
Automated Measurement of Tear Film Dynamics and Lipid Layer Thickness for Assessment of Non-SjAPgren Dry Eye Syndrome With Meibomian Gland Dysfunction. ( 27941381 )
2016
23
Alcohol consumption and dry eye syndrome: a Meta-analysis. ( 27803869 )
2016
24
A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. ( 27274185 )
2016
25
Clinical evaluation of the effect of diquafosol ophthalmic solution in glaucoma patients with dry eye syndrome. ( 26873225 )
2016
26
Over the counter (OTC) artificial tear drops for dry eye syndrome. ( 26905373 )
2016
27
Efficacy of Several Therapeutic Agents in a Murine Model of Dry Eye Syndrome. ( 27053565 )
2016
28
Effect of human milk as a treatment for dry eye syndrome in a mouse model. ( 27667918 )
2016
29
Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases. ( 26894581 )
2016
30
A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome. ( 26692423 )
2016
31
Size of the Lesions of Superficial Punctate Keratitis in Dry Eye Syndrome Observed With a Slit Lamp. ( 27124778 )
2016
32
Cryopreservation and hypothermic storage of lacrimal gland: towards enabling delivery of regenerative medicine therapies for treatment of dry eye syndrome. ( 27976538 )
2016
33
Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis. ( 27500114 )
2016
34
Angiogenin for the Diagnosis and Grading of Dry Eye Syndrome. ( 27247515 )
2016
35
Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye. ( 25668579 )
2015
36
Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients - A randomized, double-blind, placebo-controlled study. ( 25535471 )
2015
37
Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome. ( 26660938 )
2015
38
The relationship between Graves' ophthalmopathy and dry eye syndrome. ( 25584018 )
2015
39
Prospective study of ocular manifestations of pemphigus and bullous pemphigoid identifies a high prevalence of dry eye syndrome. ( 25651493 )
2015
40
Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome. ( 26818247 )
2015
41
Risk factors for the development of ocular graft-versus-host disease (GVHD) dry eye syndrome in patients with chronic GVHD. ( 25947556 )
2015
42
Relationship between symptoms of dry eye syndrome and occupational characteristics: the Korean National Health and Nutrition Examination Survey 2010-2012. ( 26511443 )
2015
43
The Effect of Hormone Replacement Therapy on Dry Eye Syndrome Evaluated with Schirmer Test and Break-Up Time. ( 26664737 )
2015
44
PROTEOMICS DIFFERENTIATE BETWEEN THYROID-ASSOCIATED ORBITOPATHY AND DRY EYE SYNDROME. ( 25829418 )
2015
45
The association between subjective and objective parameters for the assessment of dry-eye syndrome. ( 25650419 )
2015
46
Efficacy and Safety of Topical 0.05% Cyclosporine Eye Drops in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-analysis. ( 26045239 )
2015
47
Change in quality of life of patients undergoing silicone stent intubation for nasolacrimal duct stenosis combined with dry eye syndrome. ( 25947552 )
2015
48
Scleral lens use in dry eye syndrome. ( 26058032 )
2015
49
Efficacy and Safety of Carbomer-Based Lipid-Containing Artificial Tear Formulations in Patients With Dry Eye Syndrome. ( 26509769 )
2015
50
A concise overview of advances in therapeutic efficacy of serum eye drops and their alternatives to treat dry eye syndrome: Verifying the narratives of clinical consistency beyond the periphery of international inconsistency on the methods of collection and application. ( 26143344 )
2015

Variations for Dry Eye Syndrome

Expression for Dry Eye Syndrome

Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for Dry Eye Syndrome

Pathways related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 ARG1 EGF FGF2 FGF7 GDNF HGF
2
Show member pathways
13.65 EGF FGF2 FGF7 HGF HSPG2 LTF
3
Show member pathways
13.32 EGF FGF2 FGF7 HGF IL6 NGF
4
Show member pathways
13.24 EGF FGF2 FGF7 GDNF HGF IL6
5
Show member pathways
13.22 EGF FGF2 FGF7 HGF IL6 NGF
6
Show member pathways
13.13 AQP5 EGF FGF2 FGF7 HGF IL6
7
Show member pathways
12.97 EGF FGF2 FGF7 HGF IL6 NGF
8
Show member pathways
12.93 EGF FGF2 FGF7 HGF HSPG2 IL6
9
Show member pathways
12.64 EGF FGF2 FGF7 HGF NGF
10 12.62 EGF FGF2 FGF7 NGF TNF
11 12.58 EGF FGF2 FGF7 HGF IL6
12 12.42 EGF FGF2 FGF7 HGF IL6 NGF
13 12.21 FGF2 HGF HSPG2 TNF
14
Show member pathways
12.12 EGF FGF2 FGF7 HGF IL6 NGF
15
Show member pathways
12.01 HSPG2 MUC1 MUC4 MUC5AC
16 11.89 ARG1 GDNF IL6 TNF
17 11.85 EGF FGF2 FGF7 HGF IL6
18 11.79 ARG1 IL6 TNF
19 11.74 EGF FGF2 HSPG2 IL6
20 11.64 EGF FGF2 GDNF NGF
21 11.61 FGF2 HGF IL6 MUC1 TNF
22 11.54 EGF FGF2 FGF7 HGF IL6 NGF
23 11.46 FGF7 IL6 TNF
24 11.43 HGF IL6 TNF
25 11.31 AQP5 EGF HGF
26 11.24 EGF FGF2 HGF IL6
27 10.9 EGF FGF2 FGF7 HGF IL6 TNF

GO Terms for Dry Eye Syndrome

Cellular components related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ARG1 EGF FGF2 HGF HSPG2 IL6
2 Golgi lumen GO:0005796 9.55 HSPG2 MUC1 MUC4 MUC5AC NGF
3 extracellular region GO:0005576 9.55 ARG1 EGF FGF2 FGF7 GDNF HGF

Biological processes related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 GDNF HGF IL6 LACRT LTF NGF
2 peptidyl-tyrosine phosphorylation GO:0018108 9.81 EGF FGF2 FGF7 HGF
3 positive regulation of cell proliferation GO:0008284 9.8 EGF FGF2 FGF7 GDNF HGF IL6
4 response to wounding GO:0009611 9.79 ARG1 FGF7 IL6
5 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.77 HGF IL6 NGF
6 positive regulation of epithelial cell proliferation GO:0050679 9.75 FGF7 IL6 LACRT
7 O-glycan processing GO:0016266 9.74 MUC1 MUC4 MUC5AC
8 positive regulation of MAP kinase activity GO:0043406 9.73 EGF FGF2 TNF
9 humoral immune response GO:0006959 9.72 IL6 LTF TNF
10 positive regulation of osteoblast differentiation GO:0045669 9.71 HGF IL6 LTF
11 activation of MAPK activity GO:0000187 9.71 EGF FGF2 HGF TNF
12 phosphatidylinositol phosphorylation GO:0046854 9.67 EGF FGF2 FGF7 HGF
13 retina homeostasis GO:0001895 9.65 LCN1 LTF PRR4
14 positive chemotaxis GO:0050918 9.63 FGF2 FGF7 HGF
15 MAPK cascade GO:0000165 9.63 EGF FGF2 FGF7 GDNF HGF TNF
16 cellular response to hepatocyte growth factor stimulus GO:0035729 9.62 HGF IL6
17 branching involved in salivary gland morphogenesis GO:0060445 9.62 FGF7 IL6
18 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.62 EGF FGF2 FGF7 HGF
19 positive regulation of NFAT protein import into nucleus GO:0051533 9.61 LACRT TNF
20 negative regulation of lipid storage GO:0010888 9.6 IL6 TNF
21 negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 9.58 LACRT LTF
22 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.52 IL6 TNF
23 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.49 FGF7 HGF
24 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.35 EGF FGF7 HGF IL6 LACRT
25 phosphatidylinositol-mediated signaling GO:0048015 9.1 EGF FGF2 FGF7 HGF MUC5AC NGF

Molecular functions related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.62 EGF FGF2 FGF7 HGF
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.46 EGF FGF2 FGF7 HGF
3 chemoattractant activity GO:0042056 9.43 FGF2 FGF7 HGF
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.35 EGF FGF2 FGF7 GDNF HGF
5 growth factor activity GO:0008083 9.23 EGF FGF2 FGF7 GDNF HGF IL6

Sources for Dry Eye Syndrome

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