MCID: DRY001
MIFTS: 48

Dry Eye Syndrome malady

Eye diseases category

Summaries for Dry Eye Syndrome

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Wikipedia:64 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards based summary: Dry Eye Syndrome, also known as tear film insufficiency, is related to sjogren's syndrome and meningitis. An important gene associated with Dry Eye Syndrome is AQP5 (aquaporin 5), and among its related pathways are Development EGFR signaling pathway and Selected targets of ESR1. The drugs sodium chloride and hydroxyethyl cellulose and the compounds guanidine hydrochloride and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and salivary gland, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Dry Eye Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 61UMLS, 44Novoseek, 56SNOMED-CT, 28ICD9CM, 39NCIt, 34MeSH
See all sources

Dry Eye Syndrome, Aliases & Descriptions:

Name: Dry Eye Syndrome 9 11
Tear Film Insufficiency 9 61
 
Dry Eye Syndromes 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:10140
ICD9CM28 375.15
NCIt39 C34553
MeSH34 D015352

Related Diseases for Dry Eye Syndrome

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Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to dry eye syndrome

Symptoms for Dry Eye Syndrome

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Drugs & Therapeutics for Dry Eye Syndrome

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Drug clinical trials:

Search ClinicalTrials for Dry Eye Syndrome

Search NIH Clinical Center for Dry Eye Syndrome

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Dry Eye Syndrome

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Anatomical Context for Dry Eye Syndrome

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MalaCards organs/tissues related to Dry Eye Syndrome:

32
Eye, Testes, Salivary gland, Bone marrow, Bone, Thyroid

Animal Models for Dry Eye Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Dry Eye Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0MUC1, AQP5, GDNF
2MP:00053698.9NTF3, AQP5, GDNF
3MP:00053918.6NTF3, MUC1, AQP5
4MP:00053768.0AQP5, MUC1, NTF3, LTF

Publications for Dry Eye Syndrome

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Articles related to Dry Eye Syndrome:

(show top 50)    (show all 183)
idTitleAuthorsYear
1
Antioxidant and inflammatory cytokine in tears of patients with dry eye syndrome treated with preservative-free versus preserved eye drops. (24994869)
2014
2
Clinical outcomes of conjunctiva-MA1ller muscle resection: association with phenylephrine test-negative blepharoptosis and dry eye syndrome. (24670280)
2014
3
Omega-3 essential fatty acids therapy for dry eye syndrome: a meta-analysis of randomized controlled studies. (25193932)
2014
4
Rebamipide ophthalmic suspension for the treatment of dry eye syndrome: a critical appraisal. (24940041)
2014
5
Is there a relationship between pathologic myopia and dry eye syndrome? (24322801)
2014
6
Combining Sodium Hyaluronate and Polyvinylpyrrolidone Therapies for the Rabbit Cornea: A New Approach to Relief of the Human Dry Eye Syndrome. (25329624)
2014
7
The correlation of routine tear function tests and conjunctival impression cytology in dry eye syndrome. (24688254)
2014
8
A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. (24392330)
2013
9
Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. (23740519)
2013
10
Transdermal androgen patches in evaporative dry eye syndrome with androgen deficiency: a pilot study. (24344229)
2013
11
Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. (22670856)
2012
12
Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. (23272196)
2012
13
Severe dry eye syndrome after radiotherapy for head-and-neck tumors. (21764525)
2012
14
Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome. (21461217)
2011
15
Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. (21931132)
2011
16
Dry eye syndrome. (22454735)
2011
17
Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. (20847657)
2010
18
Preparation and clinical evaluation of succinylated collagen punctal plugs in dry eye syndrome: a pilot study. (20090392)
2010
19
Cationic amino acid transporters and beta-defensins in dry eye syndrome. (20502022)
2010
20
Hyperosmolarity of the tear film in dry eye syndrome. (20502033)
2010
21
Value-based medicine, comparative effectiveness, and cost-effectiveness analysis of topical cyclosporine for the treatment of dry eye syndrome. (19204231)
2009
22
Dry eye syndrome-related quality of life in glaucoma patients. (19551671)
2009
23
Advancements in anti-inflammatory therapy for dry eye syndrome. (19801339)
2009
24
Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. (18513455)
2008
25
Impact of dry eye syndrome on vision-related quality of life. (17317388)
2007
26
The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists. (16877285)
2006
27
Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. (16633024)
2006
28
Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome. (16096658)
2006
29
Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women. (15953447)
2005
30
Incomplete extrusion of an acrylic punctum plug in a case of severe dry eye syndrome. (15751253)
2005
31
Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. (15115450)
2004
32
Changes in the tear film and ocular surface from dry eye syndrome. (15219877)
2004
33
Dry eye syndrome. Etiological and therapeutic aspects. (15083682)
2003
34
Prevalence of dry eye syndrome among US women. (12888056)
2003
35
The significance of salivary gland ultrasonography in the diagnosis of dry eye syndrome. (12614055)
2002
36
Understanding dry eye syndrome. (12613883)
2002
37
Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. (11879137)
2002
38
Trehalose eye drops in the treatment of dry eye syndrome. (12414409)
2002
39
Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome? (12242131)
2002
40
Hormone replacement therapy and dry eye syndrome. (11694152)
2001
41
Efficacy and tolerability outcomes after punctal occlusion with silicone plugs in dry eye syndrome. (11678136)
2001
42
Toward optimal health: the experts discuss dry eye syndrome. Interview by Jodi Godfrey Meisler. (11703883)
2001
43
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
44
Dry eye syndrome associated with Urbach-Wiethe disease. (8880622)
1996
45
Severe dry-eye syndrome following external beam irradiation. (7960978)
1994
46
A subjective approach to the treatment of dry eye syndrome. (8030537)
1994
47
Identification of sigma receptors in lacrimocytes and their therapeutic implication in dry eye syndrome. (8030466)
1994
48
Three different types of dry eye syndrome. (8033568)
1994
49
Dry eye syndrome in long-term follow-up of bone marrow transplanted patients. (2819286)
1989
50
Dry eye syndrome and other tear film abnormalities. (7338010)
1981

Variations for Dry Eye Syndrome

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Expression for genes affiliated with Dry Eye Syndrome

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Expression patterns in normal tissues for genes affiliated with Dry Eye Syndrome

Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for genes affiliated with Dry Eye Syndrome

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Pathways related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development ERBB family signaling59
Development GDNF family signaling59
9.4MUC1, GDNF
29.2LTF, AQP5

Compounds for genes affiliated with Dry Eye Syndrome

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Compounds related to Dry Eye Syndrome according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride449.7NTF3, MUC1
2ganglioside449.7GDNF, NTF3
3melatonin44 29 60 25 1213.7NTF3, GDNF
4kainate44 2910.7GDNF, NTF3
5catecholamine449.6GDNF, NTF3
61,25 dihydroxy vitamin d3449.6GDNF, NTF3
7gold449.6NTF3, MUC1
8cocaine44 1210.6GDNF, NTF3
9periodate449.6LTF, MUC1
10metronidazole44 1210.6MUC1, LTF
11whey449.6LTF, MUC1
12bromodeoxyuridine449.5NTF3, GDNF
13capsaicin44 2910.5LTF, GDNF
14doxycycline44 1210.5LTF, GDNF
15levodopa44 1210.5LTF, GDNF
16choline44 25 1211.4GDNF, NTF3
17hydrocortisone44 3 60 1212.4LTF, MUC1
18sialic acid449.4LTF, MUC1
19matrigel449.3NTF3, MUC1
20carbohydrates449.3MUC1, LTF
21agar449.2MUC1, NTF3
22ethanol44 50 25 1212.2NTF3, MUC1, GDNF
23forskolin44 50 1211.2NTF3, MUC1, GDNF
24hyaluronic acid44 2510.2LTF, MUC1
25cyclic amp44 2510.2GDNF, MUC1, NTF3
26nitric oxide44 25 1211.1NTF3, MUC1, GDNF
27polyacrylamide449.0NTF3, LTF
28gaba449.0NTF3, GDNF
29oxygen44 2510.0NTF3, MUC1, GDNF
30creatinine449.0LTF, MUC1, GDNF
31dexamethasone44 50 29 1212.0LTF, MUC1, GDNF
32glucose449.0GDNF, MUC1, NTF3
33heparan sulfate44 259.9GDNF, NTF3, LTF
34chloramphenicol44 3 50 1211.9MUC1, NTF3, LTF
35norepinephrine44 25 1210.9GDNF, NTF3, LTF
36paraffin448.9LTF, NTF3, MUC1
37superoxide44 259.9GDNF, NTF3, LTF
38aspartate448.9LTF, NTF3, GDNF
39heparin44 29 25 1211.9GDNF, NTF3, LTF
40adenylate448.9LTF, NTF3, GDNF
41glutamate448.8LTF, NTF3, GDNF
42calcium44 50 25 1211.7GDNF, AQP5, MUC1, NTF3
43actinomycin d448.4GDNF, MUC1, NTF3, LTF
44vegf448.4LTF, NTF3, MUC1, GDNF
45retinoic acid44 259.4LTF, NTF3, MUC1, GDNF
46cysteine448.4LTF, NTF3, MUC1, GDNF
47estrogen448.0LTF, NTF3, MUC1, AQP5, GDNF

GO Terms for genes affiliated with Dry Eye Syndrome

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Cellular components related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.5MUC1, AQP5

Biological processes related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3NTF3, GDNF
2enteric nervous system developmentGO:0484849.0NTF3, GDNF

Molecular functions related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3NTF3, GDNF

Products for genes affiliated with Dry Eye Syndrome

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  • Antibodies
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Sources for Dry Eye Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet