Aliases & Classifications for Dry Eye Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 27ICD9CM, 33MeSH
See all sources

Dry Eye Syndrome, Aliases & Descriptions:

Name: Dry Eye Syndrome 9 11
Dry Eye Syndromes 43 60
 
Tear Film Insufficiency 9


External Ids:

Disease Ontology9 DOID:10140
NCIt38 C34553
ICD9CM27 375.15
MeSH33 D015352

Summaries for Dry Eye Syndrome

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Wikipedia:63 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards based summary: Dry Eye Syndrome, also known as dry eye syndromes, is related to sjogren's syndrome and blindness. An important gene associated with Dry Eye Syndrome is AQP5 (aquaporin 5), and among its related pathways are Development EGFR signaling pathway and Selected targets of ESR1. The drugs sodium chloride and hydroxyethyl cellulose and the compounds guanidine hydrochloride and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Dry Eye Syndrome

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Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to dry eye syndrome

Symptoms for Dry Eye Syndrome

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Drugs & Therapeutics for Dry Eye Syndrome

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Drug clinical trials:

Search ClinicalTrials for Dry Eye Syndrome

Search NIH Clinical Center for Dry Eye Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Dry Eye Syndrome

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Anatomical Context for Dry Eye Syndrome

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MalaCards organs/tissues related to Dry Eye Syndrome:

31
Eye, Testes, Thyroid, Salivary gland, Bone marrow, Bone

Animal Models for Dry Eye Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Dry Eye Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0MUC1, AQP5, GDNF
2MP:00053698.9NTF3, AQP5, GDNF
3MP:00053918.6NTF3, MUC1, AQP5
4MP:00053768.0AQP5, MUC1, NTF3, LTF

Publications for Dry Eye Syndrome

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Articles related to Dry Eye Syndrome:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye. (25668579)
2015
2
Prospective study of ocular manifestations of pemphigus and bullous pemphigoid identifies a high prevalence of dry eye syndrome. (25651493)
2015
3
PROTEOMICS DIFFERENTIATE BETWEEN THYROID-ASSOCIATED ORBITOPATHY AND DRY EYE SYNDROME. (25829418)
2015
4
The relationship between Graves' ophthalmopathy and dry eye syndrome. (25584018)
2015
5
Antioxidant and inflammatory cytokine in tears of patients with dry eye syndrome treated with preservative-free versus preserved eye drops. (24994869)
2014
6
Autologous serum eye drops for severe dry eye syndrome in a patient with chronic graft-versus-host disease: a case report. (25577885)
2014
7
Clinical outcomes of conjunctiva-MA1ller muscle resection: association with phenylephrine test-negative blepharoptosis and dry eye syndrome. (24670280)
2014
8
Omega-3 essential fatty acids therapy for dry eye syndrome: a meta-analysis of randomized controlled studies. (25193932)
2014
9
Rebamipide ophthalmic suspension for the treatment of dry eye syndrome: a critical appraisal. (24940041)
2014
10
Is there a relationship between pathologic myopia and dry eye syndrome? (24322801)
2014
11
Combining Sodium Hyaluronate and Polyvinylpyrrolidone Therapies for the Rabbit Cornea: A New Approach to Relief of the Human Dry Eye Syndrome. (25329624)
2014
12
The correlation of routine tear function tests and conjunctival impression cytology in dry eye syndrome. (24688254)
2014
13
A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. (24392330)
2013
14
Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. (23740519)
2013
15
Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. (22670856)
2012
16
Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. (23272196)
2012
17
Severe dry eye syndrome after radiotherapy for head-and-neck tumors. (21764525)
2012
18
Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome. (21461217)
2011
19
Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. (21931132)
2011
20
Dry eye syndrome. (22454735)
2011
21
Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. (20847657)
2010
22
Preparation and clinical evaluation of succinylated collagen punctal plugs in dry eye syndrome: a pilot study. (20090392)
2010
23
Cationic amino acid transporters and beta-defensins in dry eye syndrome. (20502022)
2010
24
Value-based medicine, comparative effectiveness, and cost-effectiveness analysis of topical cyclosporine for the treatment of dry eye syndrome. (19204231)
2009
25
Dry eye syndrome-related quality of life in glaucoma patients. (19551671)
2009
26
Advancements in anti-inflammatory therapy for dry eye syndrome. (19801339)
2009
27
Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. (18513455)
2008
28
Impact of dry eye syndrome on vision-related quality of life. (17317388)
2007
29
The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists. (16877285)
2006
30
Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. (16633024)
2006
31
Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome. (16096658)
2006
32
Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women. (15953447)
2005
33
Incomplete extrusion of an acrylic punctum plug in a case of severe dry eye syndrome. (15751253)
2005
34
Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. (15115450)
2004
35
Changes in the tear film and ocular surface from dry eye syndrome. (15219877)
2004
36
Dry eye syndrome. Etiological and therapeutic aspects. (15083682)
2003
37
Prevalence of dry eye syndrome among US women. (12888056)
2003
38
The significance of salivary gland ultrasonography in the diagnosis of dry eye syndrome. (12614055)
2002
39
Understanding dry eye syndrome. (12613883)
2002
40
Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. (11879137)
2002
41
Trehalose eye drops in the treatment of dry eye syndrome. (12414409)
2002
42
Hormone replacement therapy and dry eye syndrome. (11694152)
2001
43
Efficacy and tolerability outcomes after punctal occlusion with silicone plugs in dry eye syndrome. (11678136)
2001
44
Toward optimal health: the experts discuss dry eye syndrome. Interview by Jodi Godfrey Meisler. (11703883)
2001
45
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
46
Dry eye syndrome associated with Urbach-Wiethe disease. (8880622)
1996
47
Severe dry-eye syndrome following external beam irradiation. (7960978)
1994
48
A subjective approach to the treatment of dry eye syndrome. (8030537)
1994
49
Identification of sigma receptors in lacrimocytes and their therapeutic implication in dry eye syndrome. (8030466)
1994
50
Dry eye syndrome in long-term follow-up of bone marrow transplanted patients. (2819286)
1989

Variations for Dry Eye Syndrome

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Expression for genes affiliated with Dry Eye Syndrome

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Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for genes affiliated with Dry Eye Syndrome

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Pathways related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development ERBB family signaling58
Development GDNF family signaling58
9.4MUC1, GDNF

Compounds for genes affiliated with Dry Eye Syndrome

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Compounds related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

(show all 47)
idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride439.7NTF3, MUC1
2ganglioside439.7GDNF, NTF3
3melatonin43 28 59 24 1213.7NTF3, GDNF
4kainate43 2810.7GDNF, NTF3
5catecholamine439.6GDNF, NTF3
61,25 dihydroxy vitamin d3439.6GDNF, NTF3
7gold439.6NTF3, MUC1
8cocaine43 1210.6GDNF, NTF3
9periodate439.6LTF, MUC1
10metronidazole43 1210.6MUC1, LTF
11whey439.6LTF, MUC1
12bromodeoxyuridine439.5NTF3, GDNF
13capsaicin43 2810.5LTF, GDNF
14doxycycline43 1210.5LTF, GDNF
15levodopa43 1210.5LTF, GDNF
16choline43 24 1211.4GDNF, NTF3
17hydrocortisone43 2 59 1212.4LTF, MUC1
18sialic acid439.4LTF, MUC1
19matrigel439.3NTF3, MUC1
20carbohydrates439.3MUC1, LTF
21agar439.2MUC1, NTF3
22ethanol43 49 24 1212.2NTF3, MUC1, GDNF
23forskolin43 49 1211.2NTF3, MUC1, GDNF
24hyaluronic acid43 2410.2LTF, MUC1
25cyclic amp43 2410.2GDNF, MUC1, NTF3
26nitric oxide43 24 1211.1NTF3, MUC1, GDNF
27polyacrylamide439.0NTF3, LTF
28gaba439.0NTF3, GDNF
29oxygen43 2410.0NTF3, MUC1, GDNF
30creatinine439.0LTF, MUC1, GDNF
31dexamethasone43 49 28 1212.0LTF, MUC1, GDNF
32glucose439.0GDNF, MUC1, NTF3
33heparan sulfate43 249.9GDNF, NTF3, LTF
34chloramphenicol43 2 49 1211.9MUC1, NTF3, LTF
35norepinephrine43 24 1210.9GDNF, NTF3, LTF
36paraffin438.9LTF, NTF3, MUC1
37superoxide43 249.9GDNF, NTF3, LTF
38aspartate438.9LTF, NTF3, GDNF
39heparin43 28 24 1211.9GDNF, NTF3, LTF
40adenylate438.9LTF, NTF3, GDNF
41glutamate438.8LTF, NTF3, GDNF
42calcium43 49 24 1211.7GDNF, AQP5, MUC1, NTF3
43actinomycin d438.4GDNF, MUC1, NTF3, LTF
44vegf438.4LTF, NTF3, MUC1, GDNF
45retinoic acid43 249.4LTF, NTF3, MUC1, GDNF
46cysteine438.4LTF, NTF3, MUC1, GDNF
47estrogen438.0LTF, NTF3, MUC1, AQP5, GDNF

GO Terms for genes affiliated with Dry Eye Syndrome

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Cellular components related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163249.5MUC1, AQP5

Biological processes related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:00435249.3NTF3, GDNF
2enteric nervous system developmentGO:00484849.0NTF3, GDNF

Molecular functions related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.3NTF3, GDNF

Products for genes affiliated with Dry Eye Syndrome

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  • Antibodies
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Sources for Dry Eye Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet