MCID: DRY001
MIFTS: 47

Dry Eye Syndrome malady

Eye diseases category

Summaries for Dry Eye Syndrome

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards: Dry Eye Syndrome, also known as dry eye syndromes, is related to sjogren's syndrome and keratoconjunctivitis sicca. An important gene associated with Dry Eye Syndrome is AQP5 (aquaporin 5), and among its related pathways are Development EGFR signaling pathway and Selected targets of ESR1. The drugs sodium chloride and sodium chloride granules and the compounds guanidine hydrochloride and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and salivary gland, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Dry Eye Syndrome

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

dry eye syndrome 9 11
dry eye syndromes 46 63
tear film insufficiency 9


External Ids:

Disease Ontology9 DOID:10140
MeSH36 D015352
NCIt41 C34553
ICD9CM28 375.15

Related Diseases for Dry Eye Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to dry eye syndrome

Symptoms for Dry Eye Syndrome

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Drugs & Therapeutics for Dry Eye Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Dry Eye Syndrome

Drug clinical trials:

Search ClinicalTrials for Dry Eye Syndrome

Search NIH Clinical Center for Dry Eye Syndrome

Search CenterWatch for Dry Eye Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Dry Eye Syndrome

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Anatomical Context for Dry Eye Syndrome

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Sources:
34MalaCards
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MalaCards organs/tissues related to Dry Eye Syndrome:

34
Eye, Testes, Salivary gland, Bone marrow, Bone, Thyroid

Animal Models for Dry Eye Syndrome or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Dry Eye Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0MUC1, AQP5, GDNF
2MP:00053698.9NTF3, AQP5, GDNF
3MP:00053918.6NTF3, MUC1, AQP5
4MP:00053768.0AQP5, MUC1, NTF3, LTF

Publications for Dry Eye Syndrome

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Sources:
53PubMed
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Articles related to Dry Eye Syndrome:

(show top 50)    (show all 162)
idTitleAuthorsYear
1
Is there a relationship between pathologic myopia and dry eye syndrome? (24322801)
2014
2
A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. (24392330)
2013
3
Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. (23740519)
2013
4
Transdermal androgen patches in evaporative dry eye syndrome with androgen deficiency: a pilot study. (24344229)
2013
5
Acupuncture for dry eye syndrome after refractive surgery: study protocol for a randomized controlled trial. (24156469)
2013
6
Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. (22670856)
2012
7
Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. (23272196)
2012
8
Severe dry eye syndrome after radiotherapy for head-and-neck tumors. (21764525)
2012
9
Impact of dry eye syndrome on vision-related quality of life in a non-clinic-based general population. (22799274)
2012
10
Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome. (21461217)
2011
11
Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. (21931132)
2011
12
Dry eye syndrome. (22454735)
2011
13
Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. (20847657)
2010
14
Preparation and clinical evaluation of succinylated collagen punctal plugs in dry eye syndrome: a pilot study. (20090392)
2010
15
Cationic amino acid transporters and beta-defensins in dry eye syndrome. (20502022)
2010
16
Hyperosmolarity of the tear film in dry eye syndrome. (20502033)
2010
17
Value-based medicine, comparative effectiveness, and cost-effectiveness analysis of topical cyclosporine for the treatment of dry eye syndrome. (19204231)
2009
18
Dry eye syndrome-related quality of life in glaucoma patients. (19551671)
2009
19
Advancements in anti-inflammatory therapy for dry eye syndrome. (19801339)
2009
20
Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. (18513455)
2008
21
Impact of dry eye syndrome on vision-related quality of life. (17317388)
2007
22
Bilateral canaliculitis following SmartPLUG insertion for dry eye syndrome post LASIK surgery. (17120003)
2007
23
The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists. (16877285)
2006
24
Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. (16633024)
2006
25
Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome. (16096658)
2006
26
Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women. (15953447)
2005
27
Incomplete extrusion of an acrylic punctum plug in a case of severe dry eye syndrome. (15751253)
2005
28
Dry eye syndrome and cataract as ocular manifestations of Crohn's disease. (16417009)
2005
29
Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. (15115450)
2004
30
Changes in the tear film and ocular surface from dry eye syndrome. (15219877)
2004
31
Dry eye syndrome. Etiological and therapeutic aspects. (15083682)
2003
32
Prevalence of dry eye syndrome among US women. (12888056)
2003
33
The significance of salivary gland ultrasonography in the diagnosis of dry eye syndrome. (12614055)
2002
34
Understanding dry eye syndrome. (12613883)
2002
35
Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. (11879137)
2002
36
Trehalose eye drops in the treatment of dry eye syndrome. (12414409)
2002
37
Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome? (12242131)
2002
38
Hormone replacement therapy and dry eye syndrome. (11694152)
2001
39
Efficacy and tolerability outcomes after punctal occlusion with silicone plugs in dry eye syndrome. (11678136)
2001
40
Toward optimal health: the experts discuss dry eye syndrome. Interview by Jodi Godfrey Meisler. (11703883)
2001
41
Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. (11074805)
2000
42
Dry eye syndrome. (15010707)
1998
43
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
44
Dry eye syndrome associated with Urbach-Wiethe disease. (8880622)
1996
45
Severe dry-eye syndrome following external beam irradiation. (7960978)
1994
46
A subjective approach to the treatment of dry eye syndrome. (8030537)
1994
47
Identification of sigma receptors in lacrimocytes and their therapeutic implication in dry eye syndrome. (8030466)
1994
48
Three different types of dry eye syndrome. (8033568)
1994
49
Dry eye syndrome in long-term follow-up of bone marrow transplanted patients. (2819286)
1989
50
Dry eye syndrome and other tear film abnormalities. (7338010)
1981

Variations for Dry Eye Syndrome

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Expression for genes affiliated with Dry Eye Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dry Eye Syndrome

Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for genes affiliated with Dry Eye Syndrome

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Sources:
51PathCards, 61Thomson Reuters, 54QIAGEN, 56Reactome, 13EMD Millipore
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Pathways related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.4MUC1, GDNF
29.2LTF, AQP5

Compounds for genes affiliated with Dry Eye Syndrome

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 25HMDB, 12DrugBank, 3BitterDB, 52PharmGKB
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Compounds related to Dry Eye Syndrome according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride469.7NTF3, MUC1
2ganglioside469.7GDNF, NTF3
3melatonin46 30 62 25 1213.7NTF3, GDNF
4kainate46 3010.7GDNF, NTF3
5catecholamine469.6GDNF, NTF3
61,25 dihydroxy vitamin d3469.6GDNF, NTF3
7gold469.6NTF3, MUC1
8cocaine46 1210.6GDNF, NTF3
9periodate469.6LTF, MUC1
10metronidazole46 1210.6MUC1, LTF
11whey469.6LTF, MUC1
12bromodeoxyuridine469.5NTF3, GDNF
13capsaicin46 3010.5LTF, GDNF
14doxycycline46 1210.5LTF, GDNF
15levodopa46 1210.5LTF, GDNF
16choline46 25 1211.4GDNF, NTF3
17hydrocortisone46 3 62 1212.4LTF, MUC1
18sialic acid469.4LTF, MUC1
19matrigel469.3NTF3, MUC1
20carbohydrates469.3MUC1, LTF
21agar469.2MUC1, NTF3
22ethanol46 52 25 1212.2NTF3, MUC1, GDNF
23forskolin46 52 1211.2NTF3, MUC1, GDNF
24hyaluronic acid46 2510.2LTF, MUC1
25cyclic amp46 2510.2GDNF, MUC1, NTF3
26nitric oxide46 25 1211.1NTF3, MUC1, GDNF
27polyacrylamide469.0NTF3, LTF
28gaba469.0NTF3, GDNF
29oxygen46 2510.0NTF3, MUC1, GDNF
30creatinine469.0LTF, MUC1, GDNF
31dexamethasone46 52 30 1212.0LTF, MUC1, GDNF
32glucose469.0GDNF, MUC1, NTF3
33heparan sulfate46 259.9GDNF, NTF3, LTF
34chloramphenicol46 3 52 1211.9MUC1, NTF3, LTF
35norepinephrine46 25 1210.9GDNF, NTF3, LTF
36paraffin468.9LTF, NTF3, MUC1
37superoxide46 259.9GDNF, NTF3, LTF
38aspartate468.9LTF, NTF3, GDNF
39heparin46 30 25 1211.9GDNF, NTF3, LTF
40adenylate468.9LTF, NTF3, GDNF
41glutamate468.8LTF, NTF3, GDNF
42calcium46 52 25 1211.7GDNF, AQP5, MUC1, NTF3
43actinomycin d468.4GDNF, MUC1, NTF3, LTF
44vegf468.4LTF, NTF3, MUC1, GDNF
45retinoic acid46 259.4LTF, NTF3, MUC1, GDNF
46cysteine468.4LTF, NTF3, MUC1, GDNF
47estrogen468.0LTF, NTF3, MUC1, AQP5, GDNF

GO Terms for genes affiliated with Dry Eye Syndrome

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Sources:
17Gene Ontology
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Cellular components related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.5MUC1, AQP5

Biological processes related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3NTF3, GDNF
2enteric nervous system developmentGO:0484849.0NTF3, GDNF

Molecular functions related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3NTF3, GDNF

Products for genes affiliated with Dry Eye Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dry Eye Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet