MCID: DRY001
MIFTS: 47

Dry Eye Syndrome malady

Eye diseases category
Download this MalaCard

Summaries for Dry Eye Syndrome

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Keratoconjunctivitis sicca (KCS), also called dry eye syndrome (DES) or keratitis sicca, is an eye... more...

MalaCards: Dry Eye Syndrome, also known as dry eye syndromes, is related to sjogren's syndrome and keratoconjunctivitis sicca. An important gene associated with Dry Eye Syndrome is AQP5 (aquaporin 5), and among its related pathways are Development EGFR signaling pathway and Selected targets of ESR1. The drugs sodium chloride and sodium chloride granules and the compounds guanidine hydrochloride and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and salivary gland, and related mouse phenotypes are digestive/alimentary and muscle.

Aliases & Classifications for Dry Eye Syndrome

About this section
Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

dry eye syndrome 8 10
dry eye syndromes 45 62
tear film insufficiency 8


External Ids:

Disease Ontology8 DOID:10140
MeSH35 D015352
NCIt40 C34553
ICD9CM27 375.15

Related Diseases for Dry Eye Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to dry eye syndrome

Symptoms for Dry Eye Syndrome

About this section

Drugs & Therapeutics for Dry Eye Syndrome

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Dry Eye Syndrome

Search NIH Clinical Center for Dry Eye Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Dry Eye Syndrome

About this section

Anatomical Context for Dry Eye Syndrome

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Dry Eye Syndrome:

33
Eye, Testes, Salivary gland, Bone marrow, Bone, Thyroid

Animal Models for Dry Eye Syndrome or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Dry Eye Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0MUC1, AQP5, GDNF
2MP:00053698.9NTF3, AQP5, GDNF
3MP:00053918.6NTF3, MUC1, AQP5
4MP:00053768.0AQP5, MUC1, NTF3, LTF

Publications for Dry Eye Syndrome

About this section
Sources:
52PubMed
See all sources

Articles related to Dry Eye Syndrome:

(show top 50)    (show all 162)
idTitleAuthorsYear
1
Is there a relationship between pathologic myopia and dry eye syndrome? (24322801)
2014
2
A randomized controlled trial of omega-3 fatty acids in dry eye syndrome. (24392330)
2013
3
Enzymes of urea synthesis are expressed at the ocular surface, and decreased urea in the tear fluid is associated with dry-eye syndrome. (23740519)
2013
4
Transdermal androgen patches in evaporative dry eye syndrome with androgen deficiency: a pilot study. (24344229)
2013
5
Acupuncture for dry eye syndrome after refractive surgery: study protocol for a randomized controlled trial. (24156469)
2013
6
Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome. (22670856)
2012
7
Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. (23272196)
2012
8
Severe dry eye syndrome after radiotherapy for head-and-neck tumors. (21764525)
2012
9
Impact of dry eye syndrome on vision-related quality of life in a non-clinic-based general population. (22799274)
2012
10
Investigating the relationship between serum interleukin-17 levels and systemic immune-mediated disease in patients with dry eye syndrome. (21461217)
2011
11
Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. (21931132)
2011
12
Dry eye syndrome. (22454735)
2011
13
Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. (20847657)
2010
14
Preparation and clinical evaluation of succinylated collagen punctal plugs in dry eye syndrome: a pilot study. (20090392)
2010
15
Cationic amino acid transporters and beta-defensins in dry eye syndrome. (20502022)
2010
16
Hyperosmolarity of the tear film in dry eye syndrome. (20502033)
2010
17
Value-based medicine, comparative effectiveness, and cost-effectiveness analysis of topical cyclosporine for the treatment of dry eye syndrome. (19204231)
2009
18
Dry eye syndrome-related quality of life in glaucoma patients. (19551671)
2009
19
Advancements in anti-inflammatory therapy for dry eye syndrome. (19801339)
2009
20
Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. (18513455)
2008
21
Impact of dry eye syndrome on vision-related quality of life. (17317388)
2007
22
Bilateral canaliculitis following SmartPLUG insertion for dry eye syndrome post LASIK surgery. (17120003)
2007
23
The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists. (16877285)
2006
24
Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. (16633024)
2006
25
Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome. (16096658)
2006
26
Combined esterified estrogen and methyltestosterone treatment for dry eye syndrome in postmenopausal women. (15953447)
2005
27
Incomplete extrusion of an acrylic punctum plug in a case of severe dry eye syndrome. (15751253)
2005
28
Dry eye syndrome and cataract as ocular manifestations of Crohn's disease. (16417009)
2005
29
Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. (15115450)
2004
30
Changes in the tear film and ocular surface from dry eye syndrome. (15219877)
2004
31
Dry eye syndrome. Etiological and therapeutic aspects. (15083682)
2003
32
Prevalence of dry eye syndrome among US women. (12888056)
2003
33
The significance of salivary gland ultrasonography in the diagnosis of dry eye syndrome. (12614055)
2002
34
Understanding dry eye syndrome. (12613883)
2002
35
Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. (11879137)
2002
36
Trehalose eye drops in the treatment of dry eye syndrome. (12414409)
2002
37
Short term toxicity profile for 32 sinonasal cancer patients treated with IMRT. Can we avoid dry eye syndrome? (12242131)
2002
38
Hormone replacement therapy and dry eye syndrome. (11694152)
2001
39
Efficacy and tolerability outcomes after punctal occlusion with silicone plugs in dry eye syndrome. (11678136)
2001
40
Toward optimal health: the experts discuss dry eye syndrome. Interview by Jodi Godfrey Meisler. (11703883)
2001
41
Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. (11074805)
2000
42
Dry eye syndrome. (15010707)
1998
43
Influence of topical anesthesia on tests diagnostic of blepharitis-associated dry eye syndrome. (9145691)
1997
44
Dry eye syndrome associated with Urbach-Wiethe disease. (8880622)
1996
45
Severe dry-eye syndrome following external beam irradiation. (7960978)
1994
46
A subjective approach to the treatment of dry eye syndrome. (8030537)
1994
47
Identification of sigma receptors in lacrimocytes and their therapeutic implication in dry eye syndrome. (8030466)
1994
48
Three different types of dry eye syndrome. (8033568)
1994
49
Dry eye syndrome in long-term follow-up of bone marrow transplanted patients. (2819286)
1989
50
Dry eye syndrome and other tear film abnormalities. (7338010)
1981

Variations for Dry Eye Syndrome

About this section

Expression for genes affiliated with Dry Eye Syndrome

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Dry Eye Syndrome

Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for genes affiliated with Dry Eye Syndrome

About this section
Sources:
50PathCards, 60Thomson Reuters, 53QIAGEN, 55Reactome, 12EMD Millipore
See all sources

Pathways related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.4MUC1, GDNF
29.2LTF, AQP5

Compounds for genes affiliated with Dry Eye Syndrome

About this section
Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 11DrugBank, 3BitterDB, 51PharmGKB
See all sources

Compounds related to Dry Eye Syndrome according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1guanidine hydrochloride459.7NTF3, MUC1
2ganglioside459.7GDNF, NTF3
3melatonin45 29 61 24 1113.7NTF3, GDNF
4kainate45 2910.7GDNF, NTF3
5catecholamine459.6GDNF, NTF3
61,25 dihydroxy vitamin d3459.6GDNF, NTF3
7gold459.6NTF3, MUC1
8cocaine45 1110.6GDNF, NTF3
9periodate459.6LTF, MUC1
10metronidazole45 1110.6MUC1, LTF
11whey459.6LTF, MUC1
12bromodeoxyuridine459.5NTF3, GDNF
13capsaicin45 2910.5LTF, GDNF
14doxycycline45 1110.5LTF, GDNF
15levodopa45 1110.5LTF, GDNF
16choline45 24 1111.4GDNF, NTF3
17hydrocortisone45 3 61 1112.4LTF, MUC1
18sialic acid459.4LTF, MUC1
19matrigel459.3NTF3, MUC1
20carbohydrates459.3MUC1, LTF
21agar459.2MUC1, NTF3
22ethanol45 51 24 1112.2NTF3, MUC1, GDNF
23forskolin45 51 1111.2NTF3, MUC1, GDNF
24hyaluronic acid45 2410.2LTF, MUC1
25cyclic amp45 2410.2GDNF, MUC1, NTF3
26nitric oxide45 24 1111.1NTF3, MUC1, GDNF
27polyacrylamide459.0NTF3, LTF
28gaba459.0NTF3, GDNF
29oxygen45 2410.0NTF3, MUC1, GDNF
30creatinine459.0LTF, MUC1, GDNF
31dexamethasone45 51 29 1112.0LTF, MUC1, GDNF
32glucose459.0GDNF, MUC1, NTF3
33heparan sulfate45 249.9GDNF, NTF3, LTF
34chloramphenicol45 3 51 1111.9MUC1, NTF3, LTF
35norepinephrine45 24 1110.9GDNF, NTF3, LTF
36paraffin458.9LTF, NTF3, MUC1
37superoxide45 249.9GDNF, NTF3, LTF
38aspartate458.9LTF, NTF3, GDNF
39heparin45 29 24 1111.9GDNF, NTF3, LTF
40adenylate458.9LTF, NTF3, GDNF
41glutamate458.8LTF, NTF3, GDNF
42calcium45 51 24 1111.7GDNF, AQP5, MUC1, NTF3
43actinomycin d458.4GDNF, MUC1, NTF3, LTF
44vegf458.4LTF, NTF3, MUC1, GDNF
45retinoic acid45 249.4LTF, NTF3, MUC1, GDNF
46cysteine458.4LTF, NTF3, MUC1, GDNF
47estrogen458.0LTF, NTF3, MUC1, AQP5, GDNF

GO Terms for genes affiliated with Dry Eye Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:0163249.5MUC1, AQP5

Biological processes related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.3NTF3, GDNF
2enteric nervous system developmentGO:0484849.0NTF3, GDNF

Molecular functions related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3NTF3, GDNF

Products for genes affiliated with Dry Eye Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dry Eye Syndrome

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet