Aliases & Classifications for Dry Eye Syndrome

MalaCards integrated aliases for Dry Eye Syndrome:

Name: Dry Eye Syndrome 12 14
Dry Eye Syndromes 51 41 69
Tear Film Insufficiency 12
Xerophthalmia 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10140
ICD10 32 H04.12
MeSH 41 D015352
NCIt 46 C34553
UMLS 69 C0013238

Summaries for Dry Eye Syndrome

MalaCards based summary : Dry Eye Syndrome, also known as dry eye syndromes, is related to keratoconjunctivitis sicca and sjogren syndrome, and has symptoms including dryness of eye and dacryops. An important gene associated with Dry Eye Syndrome is AQP5 (Aquaporin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Miconazole and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and thyroid, and related phenotype is vision/eye.

Related Diseases for Dry Eye Syndrome

Diseases related to Dry Eye Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis sicca 33.2 IL6 LTF NGF TNF
2 sjogren syndrome 11.4
3 scorpion envenomation 10.5 IL6 TNF
4 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
5 perinatal necrotizing enterocolitis 10.4 EGF IL6 TNF
6 burning mouth syndrome 10.4 IL6 NGF TNF
7 critical limb ischemia 10.4 HGF IL6 TNF
8 interstitial cystitis 10.4 EGF IL6 NGF
9 laryngitis 10.3 FGF2 IL6 TNF
10 gingivitis 10.3 IL6 LTF TNF
11 localized scleroderma 10.3 BMP6 IL6 TNF
12 rasmussen encephalitis 10.3 BMP6 IL6 TNF
13 radiation proctitis 10.3 FGF2 LTF TNF
14 obstructive jaundice 10.3 HGF IL6 TNF
15 spinal cord injury 10.3 ARG1 IL6 TNF
16 streptococcal toxic-shock syndrome 10.3 IL6 TNF
17 rheumatoid lung disease 10.3 MUC1 TNF
18 stromal keratitis 10.3 IL6 LCN1 TNF
19 breast mucoepidermoid carcinoma 10.3 MUC1 MUC5AC
20 gastric ulcer 10.3 EGF FGF2 HGF
21 cystitis 10.3 EGF IL6 NGF TNF
22 familial progressive hyperpigmentation 10.2 FGF7 HGF
23 gastrointestinal system disease 10.2 IL6 LTF TNF
24 interstitial lung disease 10.2 IL6 MUC1 TNF
25 null-cell leukemia 10.2 IL6 TNF
26 fasciitis 10.2 BMP6 IL6 MUC1 TNF
27 pulmonary disease, chronic obstructive 10.2 IL6 MUC5AC TNF
28 limb ischemia 10.1 FGF2 HGF IL6 TNF
29 otitis media 10.1 IL6 MUC5AC TNF
30 aging 10.1
31 respiratory system disease 10.1 IL6 MUC5AC TNF
32 cataract 10.0
33 allergic conjunctivitis 10.0
34 conjunctivitis 10.0
35 rheumatoid arthritis 10.0
36 graft-versus-host disease 10.0
37 arthritis 10.0
38 keratitis, hereditary 9.9
39 hematopoietic stem cell transplantation 9.9
40 thyroiditis 9.9
41 chronic graft versus host disease 9.9
42 renal cell carcinoma, nonpapillary 9.8 EGF FGF2 HGF MUC1
43 cap polyposis 9.8 MUC4 MUC5AC
44 systemic lupus erythematosus 9.7
45 schopf-schulz-passarge syndrome 9.7
46 macular degeneration, age-related, 1 9.7
47 anxiety 9.7
48 microvascular complications of diabetes 5 9.7
49 multiple mitochondrial dysfunctions syndrome 5 9.7
50 crohn's disease 9.7

Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to Dry Eye Syndrome

Symptoms & Phenotypes for Dry Eye Syndrome

UMLS symptoms related to Dry Eye Syndrome:


dryness of eye, dacryops

MGI Mouse Phenotypes related to Dry Eye Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.23 AQP5 EGF FGF2 FGF7 IL6 MUC5AC

Drugs & Therapeutics for Dry Eye Syndrome

Drugs for Dry Eye Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 322)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22916-47-8 4189
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 9004-61-9 53477741 24759
3
Povidone Approved Phase 4 9003-39-8
4
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
5
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 299-42-3 9294
6
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 90-82-4 7028
7
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
8
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
9
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
10
Loteprednol Approved Phase 4,Phase 3,Phase 2 129260-79-3, 82034-46-6 9865442 444025
11
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6 32051 23994
12
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 3 56-81-5 753
13
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
14
Ethanol Approved Phase 4,Phase 2 64-17-5 702
15
Isotretinoin Approved Phase 4 4759-48-2 5282379 5538
16
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
17
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
18
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
20
Ofloxacin Approved Phase 4 82419-36-1 4583
21
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
22
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
23
Dorzolamide Approved Phase 4 120279-96-1 5284549 3154
24
Timolol Approved Phase 4,Phase 3 26839-75-8 5478 33624
25
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
26
Travoprost Approved Phase 4 157283-68-6 5282226
27
Pilocarpine Approved, Investigational Phase 4 92-13-7, 54-71-7 5910
28
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
29
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
30
Sulfacetamide Approved Phase 4 144-80-9 5320
31
Tobramycin Approved, Investigational Phase 4,Phase 1 32986-56-4 36294 5496
32
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
33
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
34
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
35
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
36
Sorbitol Approved Phase 4 50-70-4 5780
37
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
38
Dimenhydrinate Approved Phase 4 523-87-5 441281
39
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
40
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
41
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
42 Tocopherol Approved, Investigational, Nutraceutical Phase 4
43
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
44
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
45
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
46
Dehydroepiandrosterone Approved, Investigational, Nutraceutical Phase 4,Phase 2 53-43-0 9860744
47 Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 4
48
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
49 tannic acid Approved, Nutraceutical Phase 4
50 Gallopamil Investigational Phase 4 16662-47-8

Interventional clinical trials:

(show top 50) (show all 745)

# Name Status NCT ID Phase Drugs
1 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
2 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
3 Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms Unknown status NCT01382810 Phase 4 Altaire Gel forming solution;Refresh Tears
4 0.3% Sodium Hyaluronate in the Treatment of Dry Eye of Diabetic Patients Unknown status NCT02595606 Phase 4 0.3% Sodium Hyaluronate
5 A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome Unknown status NCT00344721 Phase 4 Essential fatty acid supplement
6 Comparison of Efficacy, Safety and Anti-Inflammatory Effect Between Topical 0.05%Cyclosporine A Emulsion and REFRESH® in Patients With Moderate to Severe Dry Eyes Unknown status NCT00704275 Phase 4 0.05% cyclosporin eye drop
7 Efficacy of FreshKote and Systane for the Treatment of Dry Eye and Improvement of Osmolarity Unknown status NCT01386073 Phase 4 FreshKote;Systane
8 Tear Osmolarity Over Time With Artificial Tears Unknown status NCT01227226 Phase 4 Artificial tears
9 Patient Satisfaction and Tear Osmolarity With the Use of Blink Tears, Blink Gel Tears and Systane Balance Unknown status NCT01589640 Phase 4
10 Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome Unknown status NCT02370550 Phase 4 Cyclosporin A;Prednisone;Placebo;Calcium carbonate D
11 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
12 Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue Unknown status NCT00543166 Phase 4 dehydroepiandrosterone
13 Influence of Lachrymal Substitutes on Tear Film Thickness in Patients With Moderate Dry Eye Syndrome Completed NCT01864330 Phase 4
14 Efficacy and Safety of a Treatment for Dry Eye Syndrome: Thealoz Completed NCT01742884 Phase 4
15 Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy Completed NCT00349440 Phase 4 Cyclosporine, Refresh Plus
16 Influence of Lachrymal Substitute Gels on Tear Film Thickness in Patients With Moderate to Severe Dry Eye Syndrome Completed NCT02585453 Phase 4
17 A Phase 4 Study Investigating the Efficacy of Retaine™ in Managing Signs and Symptoms Associated With Dry Eye Syndrome Completed NCT02139033 Phase 4 Retaine™
18 Comparative Study of 0.5% Carboxymethylcellulose With 0.005% Stabilized Oxychlorocomplex (PURITE™) Versus 0.5% Carboxymethylcellulose in the Treatment of Dry Eye Completed NCT00386646 Phase 4 0.5% carboxymethylcellulose (CMC) with purite and CMC alone
19 TearLab Refractive Surgery Dry Eye Study Completed NCT01176045 Phase 4
20 A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN) Completed NCT02014922 Phase 4 TheraTears® Lubricant Eye Drop;TheraTears® preservative-free single-use containers
21 Comparative Study of Rohto Dry-Aid® and Systane® Ultra in Patients With Dry Eye Completed NCT03183089 Phase 4 Rohto Dry-Aid®;Systane® Ultra
22 The Utility of in Vivo Confocal Microscopy to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With Dry Eye Disease Completed NCT02120079 Phase 4 Lotemax;Artificial Tears
23 Kynex Versus Refresh Plus Study in Subject With Dry Eye Completed NCT00809198 Phase 4
24 Comparison of Autologous Serum Versus Preservative Free Artificial Tear Completed NCT02752763 Phase 4 %40 diluted Autologous serum;Preservative free artificial tears(Tears naturale free, Refresh single dose eye drop)
25 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK). Completed NCT00620893 Phase 4 PEG- 400 based artificial tear;Systane
26 Efficacy of Optive Versus Systane Concomitant With Restasis (Cyclosporine A) for the Treatment of Dry Eye Symptoms Completed NCT00399061 Phase 4 Systane, Optive, Restasis
27 Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease Completed NCT00567177 Phase 4 Restasis, Refresh Plus
28 A Prospective, Randomized, Double-Masked, Single Center, Clinical Comparison of the Use of Systane Ultra in the Management of Dry Eyes in Bilateral Eyes Completed NCT00781092 Phase 4
29 A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye Completed NCT02951910 Phase 4
30 Evaluate Artificial Tear Efficacy in Moderate to Severe Dry Eye Completed NCT00724412 Phase 4
31 Safety and Efficacy of Carboxymethylcellulose for Ocular Surface Integrity in Symptomatic Dry Eye Completed NCT00987727 Phase 4 carboxymethylcellulose 0.5% , glycerin 0.9% (OPTIVE® MD);sodium hyaluronate 0.18% (VISMED® Multi)
32 The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye Completed NCT01268735 Phase 4 Lubricating eyedrops containing hydroxypropyl-guar
33 Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra) Completed NCT02985827 Phase 4 Rohto (r) Hydra;Systane (r) Ultra
34 Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops Completed NCT01850979 Phase 4 Tacrolimus;Olive Oil
35 Safety and Efficacy of Optive in Contact Lens Wearers With Dry Eyes Completed NCT00469573 Phase 4 1. Optive
36 Comparison of Systane Free vs. Saline in the Treatment of Dry Eye Completed NCT00388791 Phase 4 Systane Free
37 A Clinical Evaluation Pilot Study of the Efficacy of Blink® Tears Lubricant Eye Drops for the Relief of Dry Eye Symptoms Following Implantation of Tecnis® Multifocal Introcular Lens Completed NCT01061268 Phase 4 No topical artificial tear;Blink® Tears Lubricant Eye Drops
38 Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis Completed NCT00407043 Phase 4 Lotemax;Restasis
39 Efficacy and Safety of a New Multi-dose Lubricant Eye Drop Concomitant With Restasis® (Cyclosporine A) for the Treatment of Dry Eye Symptoms Completed NCT00405457 Phase 4 Restasis, Optive Tears
40 Bilateral, Masked Comparison of PEG-400 Based Artificial Tear and Systane for the Treatment of Dry Eye Signs, Symptoms and Visual Quality Completed NCT00622037 Phase 4 PEG-400 based artificial tear;Systane
41 Pilot Study on the Use of Artificial Tears to Treat Dry Eye in Glaucoma Patients Completed NCT01682460 Phase 4 Refresh Tears Lubricant Eye Drops (Allergan)
42 Efficacy Study of a New Eyedrop on Silicone Hydrogel Contact Lens Wearers With Dry Eye Complaints Completed NCT01543061 Phase 4
43 Efficacy of Systane Ultra in Post Menopausal Women With Dry Eye Completed NCT01105910 Phase 4
44 Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease Completed NCT02004067 Phase 4 Restasis;Refresh Endura
45 Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye Completed NCT01488396 Phase 4 0.05%cyclosporin eye drop
46 Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients Completed NCT01203540 Phase 4 NAABAK eyedrops;Saline eyedrops
47 Study to Compare the Efficacy and Safety of Two Non-Preserved Artificial Tears for the Treatment of Dry Eye Signs and Symptoms Completed NCT00938704 Phase 4 carboxymethylcellulose 0.5% +glycerin 0.9%;sodium hyaluronate 0.18%
48 Performance and Acceptance of Optive Versus Hylocomod Eyedrops in Patients With Dry Eye Symptoms Completed NCT00761202 Phase 4 A sterile solution containing sodium carboxymethylcellulose and glycerin, preserved with PURITE®;Sodium hyaluronate
49 A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye Completed NCT02117687 Phase 4 carboxymethylcellulose 0.5%/glycerin 0.9%;sodium hyaluronate 0.18%
50 Safety and Efficacy of Punctal Plug Insertion in Patients With Dry Eye Completed NCT01684436 Phase 4

Search NIH Clinical Center for Dry Eye Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: dry eye syndromes

Genetic Tests for Dry Eye Syndrome

Anatomical Context for Dry Eye Syndrome

MalaCards organs/tissues related to Dry Eye Syndrome:

38
Eye, Salivary Gland, Thyroid, Testes, B Cells, Bone, Neutrophil

Publications for Dry Eye Syndrome

Articles related to Dry Eye Syndrome:

(show top 50) (show all 276)
# Title Authors Year
1
Micro-instillation of fluorescein with an inoculation loop for ocular surface staining in dry eye syndrome. ( 29068175 )
2018
2
Dry eye syndrome: developments and lifitegrast in perspective. ( 29391773 )
2018
3
Feline dry eye syndrome of presumed neurogenic origin: a case report. ( 29318025 )
2018
4
Automated Measurement of Tear Film Dynamics and Lipid Layer Thickness for Assessment of Non-SjAPgren Dry Eye Syndrome With Meibomian Gland Dysfunction. ( 28060064 )
2017
5
A Controlled, Randomized Double-Blind Study to Evaluate the Safety and Efficacy of Chitosan-N-Acetylcysteine for the Treatment of Dry Eye Syndrome. ( 28441068 )
2017
6
Effects of adjuvant omega-3 fatty acid supplementation on dry eye syndrome following cataract surgery: A randomized clinical trial. ( 28367524 )
2017
7
Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome. ( 29079859 )
2017
8
Dry Eye Syndrome in Menopause and Perimenopausal Age Group. ( 28706404 )
2017
9
The Use of Topical Corticosteroids for Treatment of Dry Eye Syndrome. ( 28910552 )
2017
10
Dry Eye Syndrome ( 29262012 )
2017
11
Tear Fluid Protein Changes in Dry Eye Syndrome Associated with Rheumatoid Arthritis: A Proteomic Approach. ( 27789276 )
2017
12
A Prospective, Randomized Trial of Two Mucin Secretogogues for the Treatment of Dry Eye Syndrome in Office Workers. ( 29123104 )
2017
13
Magnitude of diabetes and hypertension among patients with Dry Eye Syndrome at a tertiary hospital of Riyadh, Saudi Arabia - A case series. ( 28559720 )
2017
14
Changes in Tear Volume after 3% Diquafosol Treatment in Patients with Dry Eye Syndrome: An Anterior Segment Spectral-domain Optical Coherence Tomography Study. ( 28752695 )
2017
15
Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome. ( 29158874 )
2017
16
Punctal occlusion for dry eye syndrome. ( 28649802 )
2017
17
Efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids in dry eye syndrome: a systematic review of randomized clinical trials. ( 28371493 )
2017
18
Topical administration of Esculetin as a potential therapy for experimental dry eye syndrome. ( 28643798 )
2017
19
Evaluation of Clinical Efficacy and Safety of a Novel Cyclosporin A Nanoemulsion in the Treatment of Dry Eye Syndrome. ( 28759302 )
2017
20
Protective effects of carbenoxolone, an 11I^-HSD1 inhibitor, against chemical induced dry eye syndrome. ( 28887719 )
2017
21
Aging eye microbiota in Dry Eye Syndrome in patients treated with Enterococcus faecium and Saccharomyces boulardii. ( 28676009 )
2017
22
Dry Eye Syndrome After Proton Therapy of Ocular Melanomas. ( 28586953 )
2017
23
Herbal Supplement in a Buffer for Dry Eye Syndrome Treatment. ( 28771187 )
2017
24
Lower Serum Vitamin D Level Was Associated with Risk of Dry Eye Syndrome. ( 28487505 )
2017
25
Sodium Hyaluronate in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-Analysis. ( 28827614 )
2017
26
Epigallocatechin Gallate-Loaded Gelatin-g-Poly(N-Isopropylacrylamide) as a New Ophthalmic Pharmaceutical Formulation for Topical Use in the Treatment of Dry Eye Syndrome. ( 28839279 )
2017
27
Aqueous Deficient Dry Eye Syndrome Post Orbital Radiotherapy: A 10-Year Retrospective Study. ( 28660094 )
2017
28
Therapeutic inhibitors for the treatment of dry eye syndrome. ( 29115899 )
2017
29
Risk of dry eye syndrome in patients treated with whole-brain radiotherapy. ( 28784430 )
2017
30
Autologous artificial tears used for treatment of dry eye syndrome in patients with chronic graft versus host disease. ( 29162791 )
2017
31
Fingerprick autologous blood: a novel treatment for dry eye syndrome. ( 28622325 )
2017
32
Understanding Symptoms and Quality of Life inA Patients With Dry Eye Syndrome. ( 27224876 )
2016
33
A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome. ( 27445067 )
2016
34
Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis. ( 27500114 )
2016
35
Cryopreservation and hypothermic storage of lacrimal gland: towards enabling delivery of regenerative medicine therapies for treatment of dry eye syndrome. ( 27976538 )
2016
36
Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases. ( 26894581 )
2016
37
The Association between Symptoms of Dry Eye Syndrome and Metabolic Outcome in a General Population in Korea. ( 27366012 )
2016
38
Alcohol consumption and dry eye syndrome: a Meta-analysis. ( 27803869 )
2016
39
Effect of human milk as a treatment for dry eye syndrome in a mouse model. ( 27667918 )
2016
40
An eye on nutrition: The role of vitamins, essential fatty acids, and antioxidants in age-related macular degeneration, dry eye syndrome, and cataract. ( 26903189 )
2016
41
Proper balance of omega-3 and omega-6 fatty acid supplements with topical cyclosporine attenuated contact lens-related dry eye syndrome. ( 27766505 )
2016
42
Examining the relationship between hormone therapy and dry-eye syndrome in postmenopausal women: a cross-sectional comparison study. ( 27003590 )
2016
43
Efficacy of a New Ocular Surface Modulator in Restoring Epithelial Changes in an In Vitro Model of Dry Eye Syndrome. ( 27163340 )
2016
44
A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome. ( 27274185 )
2016
45
Severity of dry eye syndrome is related to anti-dsDNA autoantibody in systemic lupus erythematosus patients without secondary Sjogren syndrome: A cross-sectional analysis. ( 27428227 )
2016
46
Angiogenin for the Diagnosis and Grading of Dry Eye Syndrome. ( 27247515 )
2016
47
Analysis of Factors Associated With the Tear Film Lipid Layer Thickness in Normal Eyes and Patients With Dry Eye Syndrome. ( 27537256 )
2016
48
Quality, safety and sustained therapeutic efficacy of blood-derived serum eye drops to treat dry eye syndrome: R&D road map for future progress. ( 26818750 )
2016
49
Dry Eye Syndrome in Patients with Diabetes Mellitus: Prevalence, Etiology, and Clinical Characteristics. ( 27213053 )
2016
50
A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome. ( 26692423 )
2016

Variations for Dry Eye Syndrome

Expression for Dry Eye Syndrome

Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for Dry Eye Syndrome

Pathways related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 ARG1 EGF FGF2 FGF7 HGF IL6
2
Show member pathways
13.74 BMP6 EGF FGF2 FGF7 HGF IL6
3
Show member pathways
13.46 BMP6 EGF FGF2 FGF7 HGF IL6
4
Show member pathways
13.31 BMP6 EGF FGF2 FGF7 HGF IL6
5
Show member pathways
13.28 EGF FGF2 FGF7 HGF IL6 MUC1
6
Show member pathways
13.23 BMP6 EGF FGF2 FGF7 HGF IL6
7
Show member pathways
13.19 BMP6 EGF FGF2 FGF7 HGF IL6
8
Show member pathways
13.1 AQP5 BMP6 EGF FGF2 FGF7 HGF
9
Show member pathways
12.94 BMP6 EGF FGF2 FGF7 HGF IL6
10
Show member pathways
12.92 BMP6 EGF FGF2 FGF7 HGF IL6
11
Show member pathways
12.8 EGF FGF2 FGF7 HGF IL6 NGF
12 12.75 EGF FGF2 FGF7 HGF IL6
13
Show member pathways
12.64 EGF FGF2 FGF7 HGF NGF
14 12.62 EGF FGF2 FGF7 HGF NGF TNF
15
Show member pathways
12.18 BMP6 EGF FGF2 FGF7 HGF IL6
16 11.84 EGF FGF2 FGF7 HGF IL6
17 11.8 ARG1 IL6 TNF
18 11.74 BMP6 EGF FGF2 IL6
19 11.71 FGF2 HGF IL6 MUC1 TNF
20 11.68 EGF FGF2 NGF
21 11.47 FGF7 IL6 TNF
22 11.44 HGF IL6 TNF
23 11.35 EGF FGF2 FGF7
24 11.35 EGF FGF2 HGF IL6
25 11.31 AQP5 EGF HGF
26 11.12 BMP6 HGF IL6 TNF
27 10.9 EGF FGF2 FGF7 HGF IL6 TNF
28 10.66 BMP6 EGF FGF2 FGF7 HGF IL6

GO Terms for Dry Eye Syndrome

Cellular components related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.83 ARG1 BMP6 EGF FGF2 HGF IL6
2 extracellular region GO:0005576 9.55 ARG1 BMP6 EGF FGF2 FGF7 HGF
3 platelet alpha granule lumen GO:0031093 9.5 EGF HGF ORM1
4 Golgi lumen GO:0005796 9.46 MUC1 MUC4 MUC5AC NGF
5 specific granule lumen GO:0035580 9.43 ARG1 LTF ORM1

Biological processes related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 EGF FGF2 FGF7 HGF IL6 LACRT
2 peptidyl-tyrosine phosphorylation GO:0018108 9.83 EGF FGF2 FGF7 HGF
3 MAPK cascade GO:0000165 9.83 EGF FGF2 FGF7 HGF TNF
4 positive regulation of endothelial cell proliferation GO:0001938 9.77 ARG1 BMP6 FGF2
5 response to glucocorticoid GO:0051384 9.76 BMP6 IL6 TNF
6 positive regulation of epithelial cell proliferation GO:0050679 9.75 BMP6 FGF7 LACRT
7 positive regulation of MAP kinase activity GO:0043406 9.74 EGF FGF2 TNF
8 O-glycan processing GO:0016266 9.73 MUC1 MUC4 MUC5AC
9 humoral immune response GO:0006959 9.72 IL6 LTF TNF
10 activation of MAPK activity GO:0000187 9.71 EGF FGF2 HGF TNF
11 retina homeostasis GO:0001895 9.67 LCN1 LTF PRR4
12 positive chemotaxis GO:0050918 9.65 FGF2 FGF7 HGF
13 phosphatidylinositol phosphorylation GO:0046854 9.62 EGF FGF2 FGF7 HGF
14 negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 9.61 LACRT LTF
15 negative regulation of lipid storage GO:0010888 9.6 IL6 TNF
16 positive regulation of osteoblast differentiation GO:0045669 9.56 BMP6 HGF IL6 LTF
17 positive regulation of protein kinase B signaling GO:0051897 9.55 EGF FGF2 FGF7 HGF TNF
18 positive regulation of NFAT protein import into nucleus GO:0051533 9.54 LACRT TNF
19 negative regulation of interleukin-6 production GO:0032715 9.54 HGF ORM1 TNF
20 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.51 FGF7 HGF
21 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.35 EGF FGF7 HGF IL6 LACRT
22 regulation of receptor activity GO:0010469 9.23 BMP6 FGF2 FGF7 HGF IL6 LACRT
23 negative regulation of apoptotic process GO:0043066 10.01 HGF IL6 LACRT LTF NGF

Molecular functions related to Dry Eye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 BMP6 FGF2 IL6 TNF
2 protein tyrosine kinase activity GO:0004713 9.62 EGF FGF2 FGF7 HGF
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.56 EGF FGF2 FGF7 HGF
4 chemoattractant activity GO:0042056 9.33 FGF2 FGF7 HGF
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 EGF FGF2 FGF7 HGF
6 growth factor activity GO:0008083 9.23 BMP6 EGF FGF2 FGF7 HGF IL6

Sources for Dry Eye Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
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36 KEGG
37 LifeMap
39 MedGen
41 MeSH
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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