MCID: DRY001
MIFTS: 49

Dry Eye Syndrome malady

Summaries for Dry Eye Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Keratoconjunctivitis sicca (KCS), also called keratitis sicca,xerophthalmia or dry eye syndrome (DES) is... more...

MalaCards: Dry Eye Syndrome, also known as dry eye syndromes, is related to keratoconjunctivitis sicca and arthritis. An important gene associated with Dry Eye Syndrome is AQP5 (aquaporin 5), and among its related pathways are Gastric acid secretion and O-linked glycosylation of mucins. The drugs sodium chloride and hydroxyethyl cellulose and the compounds estrogen and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and salivary gland.

Aliases & Classifications for Dry Eye Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

dry eye syndrome 8 10
dry eye syndromes 44 60
tear film insufficiency 8


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Disease Ontology8 DOID:10140
ICD9CM27 375.15
NCIt39 C34553
MeSH34 D015352

Related Diseases for Dry Eye Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Dry Eye Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis sicca30.4LTF, HSPG2
2arthritis30.3LYZ, LTF
3rheumatoid arthritis30.3LGALS1, FGF7, LTF, NTF3, HSPG2
4blepharitis30.0LACRT, LTF
5crohn's disease30.0LYZ, LTF
6sjogren's syndrome30.0HSPG2, SSB, LTF, MUC5AC, AQP5
7eye disease10.4
8allergic conjunctivitis10.3
9conjunctivitis10.3
10post-traumatic stress disorder10.1
11adult syndrome10.1
12cataract10.1
13diabetic retinopathy10.1
14glaucoma10.1
15keratitis10.1
16myopia10.1
17superficial keratitis10.1
18thyroiditis10.1
19gingivitis10.0LTF
20prostatitis10.0LTF
21pulmonary disease, chronic obstructive10.0MUC5B
22dental caries10.0LTF
23gingival overgrowth10.0FGF7
24biliary papillomatosis10.0MUC5B
25influenza10.0LTF
26sinusitis10.0MUC5B
27chorioamnionitis10.0LTF
28allergic rhinitis10.0NGF
29amyloidosis10.0LYZ
30pancreatitis10.0HSPG2, LTF
31skin disease10.0LYZ
32endometriosis10.0HGF
33phaeochromocytoma10.0NGF
34dacryoadenitis10.0HSPG2
35sarcoidosis10.0LYZ
36meningitis10.0LYZ, GDNF
37polyneuropathy10.0HSPG2, GDNF
38diabetic autonomic neuropathy10.0NGF
39irritable bowel syndrome10.0LTF
40periodontal disease10.0LYZ, LTF
41hepatitis10.0HGF, HSPG2
42chordoma10.0MUC1
43thyroid cancer10.0LGALS1, HSPG2
44eosinophilia10.0NGF, HSPG2
45malignant glioma10.0HGF, NTF3
46pulmonary fibrosis10.0HGF, FGF7
47neuroblastoma10.0NGF
48otitis media10.0LTF, MUC5AC, MUC5B
49neuroaxonal dystrophy10.0NTF3, NGF
50herpes simplex10.0NTF3, GDNF

Graphical network of the top 20 diseases related to Dry Eye Syndrome:



Diseases related to dry eye syndrome

Clinical Features for Dry Eye Syndrome

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Drugs & Therapeutics for Dry Eye Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dry Eye Syndrome

Drug clinical trials:

Search ClinicalTrials for Dry Eye Syndrome

Search NIH Clinical Center for Dry Eye Syndrome

Search CenterWatch for Dry Eye Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Dry Eye Syndrome

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Anatomical Context for Dry Eye Syndrome

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32MalaCards
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MalaCards organs/tissues related to Dry Eye Syndrome:

32
Eye, Testes, Salivary gland, Thyroid, Ovary, Bone, Bone marrow

Animal Models for Dry Eye Syndrome or affiliated genes

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Publications for Dry Eye Syndrome

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50PubMed
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Articles related to Dry Eye Syndrome:

(show top 50)    (show all 185)
idTitleAuthorsYear
1
Is there a relationship between pathologic myopia and dry eye syndrome? (24322801)
2014
2
Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome. (24287121)
2014
3
The effect of an artificial tear combining hyaluronic acid and tamarind seeds polysaccharide in patients with moderate dry eye syndrome: a new treatment for dry eye. (24030535)
2014
4
Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry. (24282230)
2014
5
Transdermal androgen patches in evaporative dry eye syndrome with androgen deficiency: a pilot study. (24344229)
2013
6
Acupuncture for dry eye syndrome after refractive surgery: study protocol for a randomized controlled trial. (24156469)
2013
7
Short-term consumption of oral omega-3 and dry eye syndrome. (23642375)
2013
8
New agents for treating dry eye syndrome. (23129303)
2013
9
Diabetes-associated dry eye syndrome in a new humanized transgenic model of type 1 diabetes. (23805032)
2013
10
Prevalence and predictors of Sjogren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye. (23001257)
2012
11
Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. (23272196)
2012
12
Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial. (23217501)
2012
13
Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome: a Japanese phase 2 clinical trial. (22739038)
2012
14
Critical involvement of macrophage infiltration in the development of SjAPgren's syndrome-associated dry eye. (22770665)
2012
15
Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. (21931132)
2011
16
Upper and lower tear menisci in SjAPgren's syndrome dry eye. (22025573)
2011
17
Usefulness of double vital staining with 1% fluorescein and 1% lissamine green in patients with dry eye syndrome. (21705877)
2011
18
Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. (20847657)
2010
19
Preparation and clinical evaluation of succinylated collagen punctal plugs in dry eye syndrome: a pilot study. (20090392)
2010
20
Cationic amino acid transporters and beta-defensins in dry eye syndrome. (20502022)
2010
21
Acupuncture reduces symptoms of dry eye syndrome: a preliminary observational study. (21138389)
2010
22
Optical quality after instillation of eyedrops in dry-eye syndrome. (20494764)
2010
23
Improved signs, symptoms, and quality of life associated with dry eye syndrome: hydroxypropyl cellulose ophthalmic insert patient registry. (20351555)
2010
24
Comparison of the clinical effects of carbomer-based lipid-containing gel and hydroxypropyl-guar gel artificial tear formulations in patients with dry eye syndrome: a 4-week, prospective, open-label, randomized, parallel-group, noninferiority study. (20171410)
2010
25
Management of evaporative dry eye in ectrodactyly-ectodermal dysplasia-clefting syndrome. (18772710)
2008
26
Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (SjAPgren's syndrome). (17600738)
2007
27
The role of conjunctival epithelial cell xanthine oxidoreductase/xanthine oxidase in oxidative reactions on the ocular surface of dry eye patients with SjAPgren's syndrome. (17523077)
2007
28
Ocular surface disease index for the diagnosis of dry eye syndrome. (17972223)
2007
29
Is dry eye syndrome a work-related disease among radiologists? (17160796)
2006
30
Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expression of TSH receptor suggests involvement of TSHR-specific autoantibodies. (15115450)
2004
31
Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. (12605039)
2003
32
Evaluation of the clinical course of dry eye syndrome. (14557170)
2003
33
Inflammation: a unifying theory for the origin of dry eye syndrome. (14723109)
2003
34
Prevalence and associations of dry eye syndrome in an older population: the Blue Mountains Eye Study. (12786773)
2003
35
Trehalose eye drops in the treatment of dry eye syndrome. (12414409)
2002
36
A randomised, crossover, multicentre study to compare the performance of 0.1% (w/v) sodium hyaluronate with 1.4% (w/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome. (12194076)
2002
37
Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. (11074805)
2000
38
Prevalence of and risk factors for dry eye syndrome. (10980773)
2000
39
Dry eye syndrome, tear film, pharmacology of eye drops, and toxicity. (10170443)
1997
40
Severe dry-eye syndrome following external beam irradiation. (7960978)
1994
41
Three different types of dry eye syndrome. (8033568)
1994
42
The efficiency of short-wave diathermy and laser stimulation of the lacrimal gland in the treatment of dry eye syndrome. (8030541)
1994
43
Systemic associations of dry-eye syndrome. (1880003)
1991
44
Punctal occlusion and blepharoplasty in patients with dry eye syndrome. (1863447)
1991
45
Does conjunctival resection in ptosis surgery lead to dry-eye syndrome? (2764434)
1989
46
The role of the Schirmer's test and orbital morphology in predicting dry-eye syndrome after blepharoplasty. (3420183)
1988
47
The significance of tear film break-up time in the diagnosis of dry eye syndrome. (3246750)
1988
48
Dry eye syndrome. (3851348)
1985
49
Dry eye syndrome and other tear film abnormalities. (7338010)
1981
50
Blepharoplasty and the dry eye syndrome: guidelines for surgery? (7255588)
1981

Genetic Variations for Dry Eye Syndrome

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Expression for genes affiliated with Dry Eye Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dry Eye Syndrome

Search GEO for disease gene expression data for Dry Eye Syndrome.

Pathways for genes affiliated with Dry Eye Syndrome

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29KEGG, 53Reactome
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Pathways related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2LYZ, AQP5
2
Hide members
9.7MUC4, MUC1, MUC5B, MUC5AC

Compounds for genes affiliated with Dry Eye Syndrome

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Dry Eye Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6AQP5, LTF
2hydrocortisone44 2 59 1113.4MUC1, LTF
3periodate4410.3LTF, MUC5AC, MUC1
4suramin44 28 1112.3P2RY2, FGF7
5c2ceramide4410.1NGF, HGF, LTF, HSPG2
6k252a4410.1HGF, NGF, NTF3
7capsaicin44 2811.0HSPG2, HGF, LTF, NGF, GDNF
8ganglioside4410.0NTF3, LGALS1, GDNF, NGF
9serine4410.0FGF7, GDNF, MUC5AC, LTF
10nmda44 2810.8GDNF, NTF3, HGF, HSPG2, NGF
11phosphatidylcholine449.8FGF7, HSPG2, LTF, NGF, MUC5AC
12norepinephrine44 11 2411.8LTF, HGF, NTF3, NGF, GDNF
13hyaluronic acid44 2410.8LCN1, FGF7, MUC1, LTF, HGF
14indomethacin44 59 28 1112.8NGF, LTF, HGF, LGALS1, HSPG2
15dmso449.8LGALS1, HGF, HSPG2, MUC5AC, MUC1
16choline44 11 2411.8NGF, GDNF, HSPG2, NTF3
17ethanol44 49 11 2412.8GDNF, MUC1, NTF3, HGF, MUC5AC
18bromodeoxyuridine449.7NTF3, HGF, FGF7, GDNF
1912-o-tetradecanoylphorbol 13-acetate449.7HGF, NTF3, NGF, MUC1, FGF7
205fluorouracil449.7MUC5AC, NGF, HGF, MUC1, FGF7
21ly294002449.7NGF, HSPG2, GDNF, HGF, NTF3
22forskolin44 49 1111.7FGF7, GDNF, MUC1, NGF, NTF3, HSPG2
23agar449.7LGALS1, MUC1, HGF, NTF3, FGF7
24genistein44 28 59 2 11 2414.7HGF, NGF, FGF7, HSPG2, NTF3, GDNF
25acetylcholine44 49 28 11 2413.7NTF3, FGF7, HSPG2, NGF, GDNF
26heparin44 28 11 2412.7LGALS1, GDNF, FGF7, LTF, NTF3, HSPG2
27inositol449.7HSPG2, P2RY2, HGF, NTF3
28paraffin449.6HGF, LTF, NTF3, MUC5AC, MUC1, LGALS1
29pd 98,059449.6FGF7, GDNF, MUC5AC, NGF, HGF, HSPG2
30creatinine449.6HGF, GDNF, LCN1, LTF, NGF, MUC1
31aspartate449.6HGF, LCN1, FGF7, GDNF, NTF3, LTF
32wortmannin449.6GDNF, FGF7, NTF3, NGF, HGF, HSPG2
33glutamine449.5LGALS1, FGF7, NGF, LTF, HGF, HSPG2
34histamine44 28 2411.5FGF7, HSPG2, MUC5AC, NTF3, LTF, NGF
35actinomycin d449.5FGF7, GDNF, MUC1, NGF, LTF, NTF3
36heparan sulfate44 2410.5FGF7, LGALS1, GDNF, NTF3, HGF, HSPG2
37oxygen44 2410.5P2RY2, HGF, MUC1, GDNF, FGF7, LGALS1
38polysaccharide449.5HGF, LTF, NGF, MUC5AC, MUC1, LGALS1
39matrigel449.4MUC1, FGF7, MUC4, HGF, NTF3, NGF
40adenylate449.4P2RY2, LTF, HGF, FGF7, GDNF, NGF
41vegf449.4LTF, GDNF, FGF7, MUC1, NGF, HSPG2
42carbohydrates449.3MUC5AC, MUC1, LGALS1, LTF
43glucose449.2MUC5AC, LGALS1, P2RY2, GDNF, NTF3, MUC1
44atp44 2810.0MUC5AC, GDNF, P2RY2, SSB, HGF, FGF7
45retinoic acid44 2410.0HGF, NTF3, MUC4, MUC1, LTF, NGF
46phosphatidylinositol449.0MUC5AC, LGALS8, P2RY2, FGF7, GDNF, NTF3
47cysteine448.9GDNF, FGF7, LCN1, MUC1, MUC5AC, NGF
48dexamethasone44 49 28 1111.9MUC5AC, HSPG2, HGF, LTF, NGF, MUC1
49tyrosine448.4P2RY2, NGF, HSPG2, NTF3, LACRT, LGALS1
50calcium44 49 11 2411.2LCN1, NTF3, HSPG2, HGF, NGF, LGALS1

GO Terms for genes affiliated with Dry Eye Syndrome

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16Gene Ontology
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Cellular components related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.2MUC4, MUC1, MUC5B, MUC5AC, NGF, HSPG2
2extracellular spaceGO:0056159.0HGF, PRR4, NGF, LGALS1, LGALS8, LYZ
3extracellular regionGO:0055767.8LTF, NTF3, LCN1, HGF, HSPG2, NGF

Biological processes related to Dry Eye Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1plasma cell differentiationGO:00231710.0LGALS1, LGALS8
2negative regulation of neuron apoptotic processGO:0435249.9GDNF, NGF, NTF3
3positive chemotaxisGO:0509189.9FGF7, NTF3, HGF
4regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:0606659.9FGF7, HGF
5O-glycan processingGO:0162669.9MUC4, MUC1, MUC5B, MUC5AC
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.7HGF, NTF3, FGF7, LACRT
7post-translational protein modificationGO:0436879.4MUC5AC, MUC5B, MUC1, MUC4

Molecular functions related to Dry Eye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.9MUC4, MUC5B, MUC5AC
2chemoattractant activityGO:0420569.5HGF, NTF3, FGF7
3growth factor activityGO:0080839.1LACRT, FGF7, GDNF, NGF, NTF3, HGF

Products for genes affiliated with Dry Eye Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dry Eye Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet