DMD
MCID: DCH001
MIFTS: 74

Duchenne Muscular Dystrophy (DMD) malady

Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases, Muscle diseases categories

Summaries for Duchenne Muscular Dystrophy

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Duchenne muscular dystrophy (dmd) is a rapidly progressive form of muscular dystrophy that occurs primarily in boys. it is caused by a mutation in a gene, called the dmd gene, which encodes the muscle protein dystrophin. boys with duchenne muscular dystrophy do not make the dystrophin protein in their muscles. duchenne mucular dystrophy is inherited in an x-linked recessive fashion; however, it may also occur in people from families without a known family history of the condition. individuals who have dmd have progressive loss of muscle function and weakness, which begins in the lower limbs. in addition to the skeletal muscles used for movement, dmd may also affect the muscles of the heart.  there is no known cure for duchenne muscular dystrophy. treatment is aimed at control of symptoms to maximize the quality of life. last updated: 1/8/2009

MalaCards: Duchenne Muscular Dystrophy, also known as muscular dystrophy, duchenne, is related to muscular dystrophy and becker muscular dystrophy. An important gene associated with Duchenne Muscular Dystrophy is DMD (dystrophin), and among its related pathways are Non-integrin membrane-ECM interactions and Mitochondrial LC-Fatty Acid Beta-Oxidation. The compounds hind iii and ecori have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, heart and smooth muscle, and related mouse phenotypes are muscle and behavior/neurological.

Disease Ontology:9 A muscular dystrophy that has material basis in x-linked disease caused by mutations in the dmd gene found on the x chromosome. it is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. it affects males whereas females can be carriers. the symptoms start before the age of six and may appear at infancy.

Wikipedia:66 Duchenne muscular dystrophy (DMD) is a recessive X-linked form of muscular dystrophy, affecting around 1... more...

Description from OMIM:48 310200

Aliases & Classifications for Duchenne Muscular Dystrophy

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9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 21GeneTests, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 32LifeMap Discovery™, 63UMLS, 59SNOMED-CT, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
duchenne muscular dystrophy:
Inheritance: X-linked recessive; Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Young adult


Aliases & Descriptions:

duchenne muscular dystrophy 9 10 44 48 11 50 32
muscular dystrophy, duchenne 9 44 21 23 63
dmd 44 50
muscular dystrophy, pseudohypertrophic progressive, duchenne type 44
severe dystrophinopathy, duchenne type 50
muscular dystrophy duchenne 46


External Ids:

Disease Ontology9 DOID:11723
NCIt41 C75482
OMIM48 310200
MESH via Orphanet37 D020388
ICD10 via Orphanet27 G71.0
SNOMED-CT via Orphanet60 76670001
UMLS via Orphanet64 C0013264

Related Diseases for Duchenne Muscular Dystrophy

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18GeneCards, 19GeneDecks
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Diseases related to Duchenne Muscular Dystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1muscular dystrophy32.4DAG1, DMD, GK, CHKB, MSTN, OTC
2becker muscular dystrophy31.2DMD, GK
3mental retardation31.0DMD, GK, OTC
4neuromuscular disease30.9MSTN, CHKB, DMD
5aland island eye disease30.7GK
6myotonic dystrophy30.7DMD, CHKB
7chronic granulomatous disease30.7DMD, OTC
8eye disease30.7OTC, GK
9limb-girdle muscular dystrophy30.7CHKB, DMD
10myopathy30.6DAG1, DMD, GK, CHKB, MSTN
11dystrophinopathies30.5DMD
12walker-warburg syndrome30.5DMD, DAG1
13hyperglycerolemia30.5GK, DMD
14distal muscular dystrophy30.4CHKB, DMD
15neuropathy30.4DAG1, DMD, MSTN
16myositis30.4DMD, CHKB, MSTN
17polymyositis30.3CHKB, DMD
18gas gangrene30.3DMD
19intellectual disability30.0GK, DMD, DAG1
20muscular dystrophy, duchenne and becker types10.8
21blindness10.7
22muscular atrophy10.6
23spinal muscular atrophy10.6
24ischemia10.5
25dysphagia10.5
26neuronitis10.5
27dilated cardiomyopathy10.5
28retinitis10.5
29pulmonary function10.5
30lateral sclerosis10.4
31nephrolithiasis10.4
32retinitis pigmentosa10.4
33cerebritis10.4
34congenital stationary night blindness10.4
35amyotrophic lateral sclerosis10.4
36night blindness10.4
37rhabdomyosarcoma10.4
38hemophilia10.4
39macroglossia10.4
40endotheliitis10.4
41centronuclear myopathy10.2
42bethlem myopathy10.2
43fukuyama congenital muscular dystrophy10.2
44attention deficit hyperactivity disorder10.2
45cardiac tamponade10.2
46diabetic ketoacidosis10.2
47wolff-parkinson-white syndrome10.2
48ichthyosis vulgaris10.2
49cystic fibrosis10.2
50diamond-blackfan anemia10.2

Graphical network of the top 20 diseases related to Duchenne Muscular Dystrophy:



Diseases related to duchenne muscular dystrophy

Symptoms for Duchenne Muscular Dystrophy

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48OMIM
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Symptoms by clinical synopsis from OMIM:

310200

Clinical features from OMIM:

310200

Drugs & Therapeutics for Duchenne Muscular Dystrophy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discovery™, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Duchenne Muscular Dystrophy

Drug clinical trials:

Search ClinicalTrials for Duchenne Muscular Dystrophy

Search NIH Clinical Center for Duchenne Muscular Dystrophy

Search CenterWatch for Duchenne Muscular Dystrophy

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Duchenne Muscular Dystrophy cell therapies at LifeMap Discovery.

Genetic Tests for Duchenne Muscular Dystrophy

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21GeneTests, 23GTR
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Genetic tests related to Duchenne Muscular Dystrophy:

id Genetic test Affiliating Genes
1 Duchenne Muscular Dystrophy21 23

Anatomical Context for Duchenne Muscular Dystrophy

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32LifeMap Discovery™, 34MalaCards
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MalaCards organs/tissues related to Duchenne Muscular Dystrophy:

34
Skeletal muscle, Heart, Smooth muscle, Bone, Testes, Eye, Brain, Lung, T cells, Endothelial, Skin, Bone marrow, Spinal cord, Liver, Retina, Cortex

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Duchenne Muscular Dystrophy:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
3 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Duchenne Muscular Dystrophy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Duchenne Muscular Dystrophy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0LTBP4, MSTN, CHKB, DMD, DAG1
2MP:00053867.6LTBP4, DAG1, DMD, GK, CHKB, MSTN

Publications for Duchenne Muscular Dystrophy

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53PubMed
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Articles related to Duchenne Muscular Dystrophy:

(show top 50)    (show all 734)
idTitleAuthorsYear
1
Effect of glutamine on glucose metabolism in children with Duchenne muscular dystrophy. (23021433)
2013
2
Reply to: Anaesthetic management in patients with Duchenne muscular dystrophy. (23446277)
2013
3
A family with fragile X syndrome, Duchenne muscular dystrophy and ichthyosis transmitted by an asymptomatic carrier. (23574351)
2013
4
Glucocorticoid treatment for the prevention of scoliosis in children with Duchenne muscular dystrophy: long-term follow-up. (23783200)
2013
5
Cardiac phenotype of Duchenne Muscular Dystrophy: insights from cellular studies. (23261966)
2013
6
Surgery for scoliosis in Duchenne muscular dystrophy. (23450561)
2013
7
Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy. (23863142)
2013
8
Duchenne muscular dystrophy fibroblast nodules: a cell-based assay for screening anti-fibrotic agents. (23552961)
2013
9
Brain natriuretic peptide is not predictive of dilated cardiomyopathy in Becker and Duchenne muscular dystrophy patients and carriers. (23870371)
2013
10
Detecting meaningful change using the North Star Ambulatory Assessment in Duchenne muscular dystrophy. (23909763)
2013
11
Independent living with Duchenne muscular dystrophy and home mechanical ventilation in areas of Japan with insufficient national welfare services. (23981723)
2013
12
Mapping contrast agent uptake and retention in MRI studies of myocardial perfusion: case control study of dogs with Duchenne muscular dystrophy. (23070737)
2013
13
Revertant fibers in the mdx murine model of Duchenne muscular dystrophy: an age- and muscle-related reappraisal. (24015212)
2013
14
Ambulatory capacity and disease progression as measured by the 6-minute-walk-distance in Duchenne muscular dystrophy subjects on daily corticosteroids. (23770101)
2013
15
Transition to adulthood for young men with Duchenne muscular dystrophy: research from the UK. (22425491)
2012
16
A critical review of functional assessment tools for upper limbs in Duchenne muscular dystrophy. (22713125)
2012
17
Drug treatment of Duchenne muscular dystrophy: available evidence and perspectives. (22655510)
2012
18
microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. (22546853)
2012
19
Proliferative retinopathy in Duchenne muscular dystrophy and its response to bevacizumab. (22594924)
2012
20
The Canadian experience with long-term deflazacort treatment in Duchenne muscular dystrophy. (22655512)
2012
21
MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy. (22980762)
2012
22
Quantitative muscle strength assessment in duchenne muscular dystrophy: longitudinal study and correlation with functional measures. (22974002)
2012
23
Quality of life in Duchenne muscular dystrophy: the subjective impact on children and parents. (21482750)
2011
24
The status of exon skipping as a therapeutic approach to duchenne muscular dystrophy. (20978473)
2011
25
Impending therapies for Duchenne muscular dystrophy. (21892079)
2011
26
miR-31 modulates dystrophin expression: new implications for Duchenne muscular dystrophy therapy. (21212803)
2011
27
Predicting the severity of Duchenne muscular dystrophy: implications for treatment. (21178098)
2011
28
Identification of muscle necrosis in the mdx mouse model of Duchenne muscular dystrophy using three-dimensional optical coherence tomography. (21806274)
2011
29
Revertant fibres and dystrophin traces in Duchenne muscular dystrophy: implication for clinical trials. (20395141)
2010
30
Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy. (20517938)
2010
31
Elaboration and reliability of functional evaluation on going up and downstairs scale for Duchenne Muscular Dystrophy. (21340247)
2010
32
Aminoglycoside-induced mutation suppression (stop codon readthrough) as a therapeutic strategy for Duchenne muscular dystrophy. (21179598)
2010
33
Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy. (20730876)
2010
34
A Two-amino Acid Mutation Encountered in Duchenne Muscular Dystrophy Decreases Stability of the Rod Domain 23 (R23) Spectrin-like Repeat of Dystrophin. (19158079)
2009
35
Immortalized skin fibroblasts expressing conditional MyoD as a renewable and reliable source of converted human muscle cells to assess therapeutic strategies for muscular dystrophies: validation of an exon-skipping approach to restore dystrophin in Duchenne muscular dystrophy cells. (19358679)
2009
36
Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study. (19713152)
2009
37
Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy. (19416897)
2009
38
Nephrolithiasis in patients with duchenne muscular dystrophy. (17707891)
2007
39
Charcot-Marie-Tooth neuropathy type 1A combined with Duchenne muscular dystrophy. (17880576)
2007
40
Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation. (17314403)
2007
41
Allogeneic umbilical cord blood stem cell transplantation in Duchenne muscular dystrophy]. (15949330)
2005
42
Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients. (15111323)
2004
43
Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy. (11087833)
2000
44
Hypercoagulable state in Duchenne muscular dystrophy]. (9294322)
1997
45
Cystic fibrosis, Duchenne muscular dystrophy and preimplantation genetic diagnosis. (9111186)
1996
46
Octreotide enhances positive calcium balance in Duchenne muscular dystrophy. (7668311)
1995
47
Duchenne muscular dystrophy: deficiency of dystrophin-associated proteins in the sarcolemma. (8469343)
1993
48
Pathogenesis of Duchenne muscular dystrophy: the calcium hypothesis revisited. (1497954)
1992
49
Apparent association of mental retardation and specific patterns of deletions screened with probes cf56a and cf23a in Duchenne muscular dystrophy. (1877622)
1991
50
Two human cDNA molecules coding for the Duchenne muscular dystrophy (DMD) locus are highly homologous. (2668885)
1989

Variations for Duchenne Muscular Dystrophy

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Duchenne Muscular Dystrophy:

65
id Symbol AA change Variation ID SNP ID
1DMDp.Leu54ArgVAR_005147
2DMDp.Lys773GluVAR_005154
3DMDp.Asp645GlyVAR_023541
4DMDp.Asp3335HisVAR_023546
5DMDp.Cys3340TyrVAR_023547

Clinvar genetic disease variations for Duchenne Muscular Dystrophy:

1 (show all 60)
id Gene Name Type Significance SNP ID Assembly Location
1DMDNM_004006.2(DMD): c.3469G> T (p.Glu1157Ter)single nucleotide variantPathogenicrs128625226GRCh37Chr X, 32472913: 32472913
2DMDNM_004006.2(DMD): c.2791G> T (p.Glu931Ter)single nucleotide variantPathogenicrs128625227GRCh37Chr X, 32503048: 32503048
3DMDNM_004006.2(DMD): c.5551C> T (p.Gln1851Ter)single nucleotide variantPathogenicrs128625228GRCh37Chr X, 32364095: 32364095
4DMDNM_004006.2(DMD): c.8944C> T (p.Arg2982Ter)single nucleotide variantPathogenicrs128625229GRCh37Chr X, 31462738: 31462738
5DMDDMD, IVS68, T-A, +2single nucleotide variantPathogenic
6DMDNM_004006.2(DMD): c.10108C> T (p.Arg3370Ter)single nucleotide variantPathogenicrs104894787GRCh37Chr X, 31196901: 31196901
7DMDDMD, EX73-76DELdeletionPathogenic
8DMDDMD, 1-BP DEL, 10662TdeletionPathogenic
9DMDDMD, 1-BP INS, EX12insertionPathogenic
10DMDDMD, AG-T, EX48undetermined variantPathogenic
11DMDDMD, EX21DELdeletionPathogenic
12DMDDMD, EX18DELdeletionPathogenic
13DMDNM_004006.2(DMD): c.6955C> T (p.Gln2319Ter)single nucleotide variantPathogenicrs128625230GRCh37Chr X, 31893448: 31893448
14DMDNM_004006.2(DMD): c.253C> T (p.Gln85Ter)single nucleotide variantPathogenicrs128626234GRCh37Chr X, 32862911: 32862911
15DMDNM_004006.2(DMD): c.2302C> T (p.Arg768Ter)single nucleotide variantPathogenicrs201366610GRCh37Chr X, 32519950: 32519950
16DMDDMD, 1-BP DEL, 2568CdeletionPathogenic
17DMDNM_004006.2(DMD): c.2314G> T (p.Glu772Ter)single nucleotide variantPathogenicrs267606770GRCh37Chr X, 32519938: 32519938
18DMDNM_004006.2(DMD): c.433C> T (p.Arg145Ter)single nucleotide variantPathogenicrs128626235GRCh37Chr X, 32834682: 32834682
19DMDNM_004006.2(DMD): c.161T> G (p.Leu54Arg)single nucleotide variantPathogenicrs128626231GRCh37Chr X, 32867870: 32867870
20DMDDMD, IVS26, T-G, +2single nucleotide variantPathogenic
21DMDDMD, 1-BP DEL, 724CdeletionPathogenic
22DMDNM_004006.2(DMD): c.2017C> T (p.Gln673Ter)single nucleotide variantPathogenicrs128626232GRCh37Chr X, 32563427: 32563427
23DMDDMD, 1-BP DEL, 10334C AND IVS69, G-T, +1deletionPathogenic
24DMDNM_004006.2(DMD): c.178C> T (p.Gln60Ter)single nucleotide variantPathogenicrs128626233GRCh37Chr X, 32867853: 32867853
25DMDDMD, 1-BP INS, 402AinsertionPathogenic
26DMDNM_000109.3(DMD): c.700C> T (p.Gln234Ter)single nucleotide variantPathogenicrs128626238GRCh37Chr X, 32717336: 32717336
27DMDNM_004006.2(DMD): c.748G> T (p.Glu250Ter)single nucleotide variantPathogenicrs128626239GRCh37Chr X, 32717312: 32717312
28DMDDMD, 11-BP DEL, NT989deletionPathogenic
29DMDDMD, 1-BP INS, NT1554insertionPathogenic
30DMDNM_004006.2(DMD): c.1489C> T (p.Gln497Ter)single nucleotide variantPathogenicrs128626241GRCh37Chr X, 32613987: 32613987
31DMDNM_004006.2(DMD): c.1952G> A (p.Trp651Ter)single nucleotide variantPathogenicrs128626242GRCh37Chr X, 32583859: 32583859
32DMDNM_004006.2(DMD): c.2308A> T (p.Lys770Ter)single nucleotide variantPathogenicrs128626243GRCh37Chr X, 32519944: 32519944
33DMDNM_004006.2(DMD): c.2317A> G (p.Lys773Glu)single nucleotide variantPathogenicrs128626244GRCh37Chr X, 32519935: 32519935
34DMDDMD, 52-BP DELdeletionPathogenic
35DMDDMD, 1-BP INS, NT2928insertionPathogenic
36DMDNM_004006.2(DMD): c.3121C> T (p.Gln1041Ter)single nucleotide variantPathogenicrs128626245GRCh37Chr X, 32486656: 32486656
37DMDNM_004006.2(DMD): c.3188G> A (p.Trp1063Ter)single nucleotide variantPathogenicrs128626246GRCh37Chr X, 32482791: 32482791
38DMDNM_004006.2(DMD): c.4213C> T (p.Gln1405Ter)single nucleotide variantPathogenicrs128626247GRCh37Chr X, 32429889: 32429889
39DMDNM_004006.2(DMD): c.4414C> T (p.Gln1472Ter)single nucleotide variantPathogenicrs128626248GRCh37Chr X, 32407722: 32407722
40DMDNM_004006.2(DMD): c.5899C> T (p.Arg1967Ter)single nucleotide variantPathogenicrs128626249GRCh37Chr X, 32360240: 32360240
41DMDDMD, 1-BP DEL, 6408CdeletionPathogenic
42DMDNM_004006.2(DMD): c.6292C> T (p.Arg2098Ter)single nucleotide variantPathogenicrs128626250GRCh37Chr X, 32235179: 32235179
43DMDNM_004006.2(DMD): c.6373C> T (p.Gln2125Ter)single nucleotide variantPathogenicrs128626251GRCh37Chr X, 32235098: 32235098
44DMDDMD, 17-BP DEL, NT6982deletionPathogenic
45DMDNM_004006.2(DMD): c.6790C> T (p.Gln2264Ter)single nucleotide variantPathogenicrs128626252GRCh37Chr X, 31947835: 31947835
46DMDDMD, 1-BP INS, 7188AinsertionPathogenic
47DMDDMD, IVS47, G-A, +1, EX48DELdeletionPathogenic
48DMDNM_004006.2(DMD): c.7402G> T (p.Glu2468Ter)single nucleotide variantPathogenicrs128626253GRCh37Chr X, 31792217: 31792217
49DMDNM_004006.2(DMD): c.8729A> T (p.Glu2910Val)single nucleotide variantBenign, Pathogenicrs41305353GRCh37Chr X, 31496431: 31496431
50DMDNM_004006.2(DMD): c.8734A> G (p.Asn2912Asp)single nucleotide variantBenign, Pathogenicrs1800278GRCh37Chr X, 31496426: 31496426
51DMDNM_004006.2(DMD): c.9197C> A (p.Ser3066Ter)single nucleotide variantPathogenicrs128626254GRCh37Chr X, 31341742: 31341742
52DMDDMD, 4-BP DEL, NT9679deletionPathogenic
53DMDDMD, IVS65, G-A, +1single nucleotide variantPathogenic
54DMDNM_004006.2(DMD): c.10141C> T (p.Arg3381Ter)single nucleotide variantPathogenicrs104894790GRCh37Chr X, 31196868: 31196868
55DMDDMD, IVS70, G-T, +5single nucleotide variantPathogenic
56DMDDMD, 8-BP DEL, 1-BP INS, NT10692indelPathogenic
57DMDNM_004006.2(DMD): c.9568C> T (p.Arg3190Ter)single nucleotide variantPathogenicrs104894797GRCh37Chr X, 31224780: 31224780
58DMDDMD, 1-BP DEL, 377AdeletionPathogenic
59DMDNM_004006.2(DMD): c.8713C> T (p.Arg2905Ter)single nucleotide variantPathogenicrs128627256GRCh37Chr X, 31496447: 31496447
60DMDNM_004006.2(DMD): c.5985T> G (p.Tyr1995Ter)single nucleotide variantPathogenicrs128627257GRCh37Chr X, 32328331: 32328331

Expression for genes affiliated with Duchenne Muscular Dystrophy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Duchenne Muscular Dystrophy

Search GEO for disease gene expression data for Duchenne Muscular Dystrophy.

Pathways for genes affiliated with Duchenne Muscular Dystrophy

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Pathways related to Duchenne Muscular Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Proteogylcan syndecan-mediated signaling events39
10.0DMD, DAG1
2
Show member pathways
fatty acid beta-oxidation III (unsaturated, odd number)39
Fatty Acid Beta Oxidation39
9.8CHKB, GK
3
Show member pathways
9.7LTBP4, DMD, DAG1
49.6C1QB, C1QC
5
Show member pathways
9.4SNTB1, DMD, DAG1
69.4SNTB1, DMD, DAG1

Compounds for genes affiliated with Duchenne Muscular Dystrophy

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46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank
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Compounds related to Duchenne Muscular Dystrophy according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1hind iii4610.1OTC, DMD
2ecori4610.0DMD, OTC
3ornithine46 2511.0OTC, CHKB, DMD
4tositumomab52 1211.0C1QB, C1QC
5ibritumomab52 1210.9C1QC, C1QB
6succinate469.9DMD, GK, CHKB
7alefacept46 1210.9C1QC, C1QB
8bevacizumab52 1210.9C1QB, C1QC
9urea46 25 1211.9OTC, CHKB, DMD
10efalizumab46 1210.9C1QC, C1QB
11daclizumab46 1210.9C1QB, C1QC
12basiliximab46 1210.9C1QC, C1QB
13natalizumab46 1210.8C1QB, C1QC
14alemtuzumab46 1210.8C1QB, C1QC
15gemtuzumab ozogamicin52 46 1211.8C1QC, C1QB
16adalimumab46 52 1211.7C1QC, C1QB
17glycerol46 25 1211.7OTC, CHKB, GK, DMD
18abciximab46 1210.6CHKB, C1QC, C1QB
19etanercept46 52 1211.6C1QC, C1QB
20creatinine469.5OTC, CHKB, GK, DMD
21pyruvate469.4OTC, CHKB, GK
22cetuximab46 52 1211.3C1QC, C1QB
23glucose469.2DMD, GK, CHKB, MSTN, OTC
24sodium46 2510.1OTC, SNTB2, SNTB1, DMD
25calcium46 52 25 1211.0SNTB2, SNTB1, CHKB, C1QC, C1QB, DMD

GO Terms for genes affiliated with Duchenne Muscular Dystrophy

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17Gene Ontology
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Cellular components related to Duchenne Muscular Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1syntrophin complexGO:01601310.0SNTG2, DMD
2filopodiumGO:03017510.0DMD, DAG1
3costamereGO:0430349.9DMD, DAG1
4sarcolemmaGO:0423839.2DAG1, DMD, SNTB1, SNTG2
5cytoskeletonGO:0058569.1DAG1, DMD, SNTB1, SNTG2
6dystrophin-associated glycoprotein complexGO:0160109.0SNTB2, SNTB1, DMD, DAG1
7protein complexGO:0432348.8SNTB2, SNTB1, DMD

Biological processes related to Duchenne Muscular Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.7LTBP4, DMD, DAG1
2complement activationGO:0069569.5C1QC, C1QB
3complement activation, classical pathwayGO:0069589.3C1QC, C1QB

Molecular functions related to Duchenne Muscular Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of muscleGO:00830710.0DMD, DAG1
2dystroglycan bindingGO:0021629.9DAG1, DMD
3vinculin bindingGO:0171669.7DMD, DAG1
4actin bindingGO:0037798.5SNTB2, SNTG2, SNTB1, DMD, DAG1

Products for genes affiliated with Duchenne Muscular Dystrophy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Duchenne Muscular Dystrophy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet