MCID: DCT002
MIFTS: 36

Ductal Carcinoma in Situ malady

Cancer diseases category

Aliases & Classifications for Ductal Carcinoma in Situ

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Ductal Carcinoma in Situ, Aliases & Descriptions:

Name: Ductal Carcinoma in Situ 9 11
 
Noninfiltrating Intraductal Carcinoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:0060074

Summaries for Ductal Carcinoma in Situ

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Wikipedia:63 Ductal carcinoma in situ (DCIS), also known as intraductal carcinoma, is a pre-cancerous or non-invasive... more...

MalaCards based summary: Ductal Carcinoma in Situ, also known as noninfiltrating intraductal carcinoma, is related to breast cancer and breast ductal carcinoma. An important gene associated with Ductal Carcinoma in Situ is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2). The compounds megestrol acetate and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and testes, and related mouse phenotypes are digestive/alimentary and normal.

Related Diseases for Ductal Carcinoma in Situ

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Diseases related to Ductal Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer32.2PGR, ERBB2
2breast ductal carcinoma31.6TFF1, ERBB2, PGR
3breast disease31.1PGR, ERBB2
4papilloma30.6ACTC1, KRT14
5papillary carcinoma30.2PGR, KRT14, ERBB2, ACTC1
6gynecomastia10.7
7intraductal papilloma10.6
8lobular neoplasia10.6
9breast reconstruction10.6
10hypoxia10.5
11breast fibroadenoma10.4PGR
12leiomyomatosis10.4PGR
13retinoblastoma10.3
14obesity10.3
15poland syndrome10.3
16prolactinoma10.3
17pyoderma gangrenosum10.3
18comedo carcinoma10.3
19bilateral breast cancer10.3
20hidradenoma10.3
21neuroendocrine tumor10.3
22ovarian cyst10.3
23pyoderma10.3
24phyllode tumor10.3
25mammary paget's disease10.3PGR, ERBB2
26inflammatory breast carcinoma10.2ERBB2, PGR
27endometrial cancer10.2ERBB2, PGR
28gastric adenocarcinoma10.1TFF1, CLDN7, ERBB2
29spindle cell carcinoma10.1ACTC1, PGR
30adenosarcoma10.1PGR, ACTC1
31endometrial stromal sarcoma10.1ACTC1, PGR
32li-fraumeni syndrome10.1TFF1, PGR, ERBB2
33angiomyolipoma10.1ACTC1, PGR
34smooth muscle tumor10.1PGR, ACTC1
35bladder cancer, somatic10.0ERBB2, ACTC1
36leiomyosarcoma10.0ACTC1, PGR
37oxyphilic adenoma10.0KRT14, CLDN7
38malignant mixed mullerian tumor10.0PGR, ACTC1, ERBB2
39tubular adenocarcinoma10.0PGR, ACTC1, ERBB2
40myoepithelioma10.0ACTC1, KRT14
41fibromatosis10.0TFF1, PGR, ACTC1
42leiomyoma10.0PGR, ACTC1
43ovarian cancer, somatic9.9ERBB2, PGR, TFF1
44angiosarcoma9.9ACTC1, KRT14
45squamous cell carcinoma, head and neck9.9ERBB2, KRT14, CLDN7
46mucoepidermoid carcinoma9.9KRT14, ACTC1
47pleomorphic adenoma9.9ACTC1, ERBB2, KRT14
48salivary gland adenoid cystic carcinoma9.9ERBB2, KRT14, ACTC1
49lung cancer9.8ERBB2, SAGE1, TFF1, KRT14
50kidney cancer9.7CLDN7, KRT14, ACTC1

Graphical network of the top 20 diseases related to Ductal Carcinoma in Situ:



Diseases related to ductal carcinoma in situ

Symptoms for Ductal Carcinoma in Situ

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Drugs & Therapeutics for Ductal Carcinoma in Situ

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Drug clinical trials:

Search ClinicalTrials for Ductal Carcinoma in Situ

Search NIH Clinical Center for Ductal Carcinoma in Situ

Genetic Tests for Ductal Carcinoma in Situ

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Anatomical Context for Ductal Carcinoma in Situ

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MalaCards organs/tissues related to Ductal Carcinoma in Situ:

31
Breast, Lymph node, Testes, Bone marrow, Bone, Smooth muscle, Salivary gland, Cervix, Monocytes

Animal Models for Ductal Carcinoma in Situ or affiliated genes

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MGI Mouse Phenotypes related to Ductal Carcinoma in Situ:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9TFF1, TNFRSF4, FOXC1, ERBB2, KRT14
2MP:00028738.4TNFRSF4, ERBB2, ACTC1, FOXC1, PGR
3MP:00107718.3FOXC1, KRT14, ERBB2, PGR, TFF1, CLDN7
4MP:00020068.3TFF1, KRT14, ERBB2, PGR, TMEM158
5MP:00053788.2KRT14, ERBB2, ACTC1, FOXC1, TNFRSF4, CLDN7
6MP:00053848.2ERBB2, ACTC1, FOXC1, PGR, TNFRSF4, KRT14
7MP:00053767.8PGR, KRT14, ERBB2, ACTC1, FOXC1, TFF1

Publications for Ductal Carcinoma in Situ

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Articles related to Ductal Carcinoma in Situ:

(show top 50)    (show all 714)
idTitleAuthorsYear
1
Histopathological characteristics of breast ductal carcinoma in situ and association with imaging findings. (25644245)
2015
2
Paget's disease of the male breast with underlying ductal carcinoma in situ ('DCIS'). (25832464)
2015
3
Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. (24948027)
2014
4
Molecular Pathology: SY18-1 MOLECULAR PROFILING OF BREAST DUCTAL CARCINOMA IN-SITU. (25188123)
2014
5
Post-operative radiotherapy for ductal carcinoma in situ of the breast. (24259251)
2013
6
Hypofractionated radiation therapy for breast ductal carcinoma in situ. (24113057)
2013
7
Patient, tumor and therapeutic features related to recurrence of ductal carcinoma in situ (DCIS). (24322025)
2013
8
Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. (23208501)
2013
9
US appearance of ductal carcinoma in situ. (23322838)
2013
10
Clinicopathologic features of ductal carcinoma in situ in young women with an emphasis on molecular subtype. (24029706)
2013
11
Factors influencing the quality of local management of ductal carcinoma in situ: a cohort study. (23737691)
2013
12
Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: a preclinical study. (23184608)
2013
13
Challenging paradigms: long non-coding RNAs in breast ductal carcinoma in situ (DCIS). (23577021)
2013
14
Molecular phenotypes of ductal carcinoma-in-situ and invasive ductal carcinoma: a comparative study. (22499299)
2012
15
Neuroendocrine ductal carcinoma in situ, comedo type, of the breast detected by screening mammography: a potentially pre-invasive counterpart of high grade neuroendocrine tumours. (22437750)
2012
16
Multi-institutional experience of ductal carcinoma in situ in black vs white patients treated with breast-conserving surgery and whole breast radiation therapy. (22672752)
2012
17
Predictors of invasive breast cancer and lymph node involvement in ductal carcinoma in situ initially diagnosed by vacuum-assisted breast biopsy: experience of 733 cases. (22795363)
2012
18
Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia. (22134623)
2012
19
ACR appropriateness criteria(Ar) ductal carcinoma in situ. (22107336)
2012
20
Cell polarity, epithelial-mesenchymal transition, and cell-fate decision gene expression in ductal carcinoma in situ. (22577534)
2012
21
Breast cancer and ductal carcinoma in situ among women with prior squamous or glandular precancer in the cervix: a register-based study. (23011481)
2012
22
Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. (21145284)
2011
23
Development and pilot testing of a communication aid to assist clinicians to communicate with women diagnosed with ductal carcinoma in situ (DCIS). (21088858)
2011
24
Intraoperative assessment of surgical margins during breast conserving surgery of ductal carcinoma in situ by use of radiofrequency spectroscopy. (21885281)
2011
25
Tissue microarray-based immunohistochemical study can significantly underestimate the expression of HER2 and progesterone receptor in ductal carcinoma in situ of the breast. (20701550)
2011
26
Ductal carcinoma in situ at core-needle biopsy: meta-analysis of underestimation and predictors of invasive breast cancer. (21493791)
2011
27
Mammographycally occult high grade ductal carcinoma in situ (DCIS) as second primary breast cancer, detected with MRI: a case report. (22933920)
2010
28
Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast. (20704578)
2010
29
Changes in invasive breast cancer and ductal carcinoma in situ rates in relation to the decline in hormone therapy use. (21060026)
2010
30
Ductal carcinoma in situ: terminology, classification, and natural history. (20956817)
2010
31
Proceedings of the National Institutes of Health State-of-the-Science Conference, Diagnosis and Management of Ductal Carcinoma In Situ. September 2009. (21312388)
2010
32
Coronal serial sequential sampling of breast specimen in the assessment of the extent of ductal carcinoma in situ. (19722734)
2009
33
P63 and cytokeratin8/18 expression in breast, atypical ductal hyperplasia, ductal carcinoma in situ and invasive duct carcinoma. (19190693)
2007
34
Ductal carcinoma in situ in BRCA mutation carriers. (17210933)
2007
35
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast. (16807982)
2006
36
Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? (15832086)
2005
37
Incidence and clinical significance of lymph node metastasis detected by cytokeratin immunohistochemical staining in ductal carcinoma in situ. (15827818)
2005
38
S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast. (15217497)
2004
39
p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2. (15318938)
2004
40
Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. (14717665)
2004
41
Evaluation of MUC1 splice variants as prognostic markers in patients with ductal carcinoma in situ of the breast. (14534730)
2003
42
Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast. (12147647)
2002
43
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast. (12016391)
2002
44
Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. (11912139)
2002
45
Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. (12434415)
2002
46
p53 missense mutations in microdissected high-grade ductal carcinoma in situ of the breast. (11333292)
2001
47
Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. (11381366)
2001
48
Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. (11114859)
2000
49
Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast. (9212742)
1997
50
Controversies in the treatment of ductal carcinoma in situ. (8610262)
1996

Variations for Ductal Carcinoma in Situ

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Cosmic variations for Ductal Carcinoma in Situ:

7 (show all 31)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
144737TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
210701TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
310662TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
410867TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
543714TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
644901TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
711089TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
843559TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
910779TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
106932TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
1143814TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
1210660TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
13144210TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
1410656TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
1544415TP53breast,NS,carcinoma in situ,ductal carcinoma in situ3
1627541PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
171191159PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
1829326PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
19754PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
20776PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
21763PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
2229329PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
23775PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
2430744PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
25760PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
2629325PIK3CAbreast,NS,carcinoma in situ,ductal carcinoma in situ3
2733765AKT1breast,NS,carcinoma in situ,ductal carcinoma in situ3
2834142AKT1breast,NS,carcinoma in situ,ductal carcinoma in situ3
2919786CDH1breast,NS,carcinoma in situ,ductal carcinoma in situ3
30520KRASbreast,NS,carcinoma in situ,ductal carcinoma in situ3
3114060ERBB2breast,NS,carcinoma in situ,ductal carcinoma in situ3

Expression for genes affiliated with Ductal Carcinoma in Situ

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Search GEO for disease gene expression data for Ductal Carcinoma in Situ.

Pathways for genes affiliated with Ductal Carcinoma in Situ

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Compounds for genes affiliated with Ductal Carcinoma in Situ

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Compounds related to Ductal Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1megestrol acetate4310.1ERBB2, PGR
2capecitabine43 49 1212.1PGR, ERBB2
3exemestane43 49 59 1213.1ERBB2, PGR
4anastrozole43 49 1212.1ERBB2, PGR
5lapatinib43 49 1212.0ERBB2, PGR
62-methoxyethanol4310.0ACTC1, KRT14
7mucicarmine4310.0ACTC1, KRT14
8bisphenol a4310.0TFF1, PGR
9taxane4310.0ERBB2, PGR
10steroidal439.9PGR, TFF1
11leucovorin43 49 1211.9PGR, ERBB2
12diethylstilbestrol43 28 1211.9PGR, TFF1
13toremifene43 1210.9ERBB2, PGR, TFF1
14fulvestrant43 49 28 1212.8ERBB2, PGR, TFF1
15letrozole43 49 59 1212.8TFF1, PGR, ERBB2
16progestins439.8PGR, TFF1
174-hydroxytamoxifen439.8TFF1, PGR, ERBB2
18progestin439.8ERBB2, PGR, TFF1
19resveratrol43 59 24 1212.8ERBB2, PGR, TFF1
20hematoxylin439.8KRT14, ACTC1, TFF1
21raloxifene43 49 28 1212.8ERBB2, PGR
22retinoid439.5KRT14, PGR, TFF1
23trastuzumab43 49 1211.5ERBB2, PGR
24tamoxifen43 49 28 1212.4TFF1, PGR, ERBB2, KRT14
25testosterone43 59 24 1212.4TFF1, PGR, ACTC1, ERBB2
26genistein43 28 59 2 24 1214.4TFF1, PGR, ERBB2
27dexamethasone43 49 28 1212.3TFF1, PGR, ACTC1, ERBB2
28cyclosporin a43 28 5911.3ACTC1, PGR, TNFRSF4
29vegf439.3TFF1, PGR, ACTC1, ERBB2
30paraffin439.1TFF1, PGR, ACTC1, ERBB2, KRT14
31estrogen439.0TFF1, PGR, ACTC1, ERBB2, KRT14
32retinoic acid43 2410.0TFF1, PGR, ACTC1, KRT14
33steroid438.9TAS2R64P, ERBB2, ACTC1, PGR, TFF1
34progesterone43 28 59 24 1212.6TAS2R64P, TFF1, PGR, ACTC1, ERBB2, KRT14

GO Terms for genes affiliated with Ductal Carcinoma in Situ

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Products for genes affiliated with Ductal Carcinoma in Situ

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Sources for Ductal Carcinoma in Situ

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet