MCID: DCT002
MIFTS: 46

Ductal Carcinoma in Situ malady

Cancer diseases category

Summaries for Ductal Carcinoma in Situ

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Mammary ductal carcinoma is the most common type of breast cancer in women. It comes in two forms:... more...

MalaCards: Ductal Carcinoma in Situ is related to breast cancer and papilloma. An important gene associated with Ductal Carcinoma in Situ is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are Akt Signaling and GPCR Pathway. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and testes, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Ductal Carcinoma in Situ

About this section
Sources:
8Disease Ontology, 10DISEASES
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ductal carcinoma in situ 8 10


External Ids:

Disease Ontology8 DOID:0060074

Related Diseases for Ductal Carcinoma in Situ

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Ductal Carcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.7CCND1, TFF1, PIP, PGR, KRT14, MST1R
2papilloma30.9ACTC1, KRT14, KRT5
3papillary carcinoma30.8ERBB2, ACTC1, KRT14, PGR
4squamous cell carcinoma30.3TFF1, S100A7, CCND1, KLK10, PIP, CLDN7
5inflammatory breast carcinoma30.3ERBB2, PGR
6hidradenoma30.3PIP
7in situ carcinoma11.6
8breast carcinoma in situ11.5
9breast disease10.7
10gynecomastia10.6
11comedo carcinoma10.6
12lymph node cancer10.6
13breast reconstruction10.5
14intraductal papilloma10.5
15neuroendocrine carcinoma10.5
16flat ductal epithelial atypia10.5
17breast papillary carcinoma10.5
18lobular neoplasia10.5
19breast apocrine carcinoma10.4
20breast apocrine carcinoma in situ10.4
21cribriform carcinoma10.3
22sclerosing adenosis of breast10.3
23bilateral breast cancer10.3
24breast intraductal proliferative lesion10.3
25prolactinoma10.2
26estrogen-receptor positive breast cancer10.2
27estrogen-receptor negative breast cancer10.2
28progesterone-receptor negative breast cancer10.2
29parathyroid carcinoma10.2
30breast adenomyoepithelioma10.2
31bone carcinoma10.2
32mccune albright syndrome10.2
33proteus syndrome10.2
34synchronous bilateral breast carcinoma10.2
35breast myoepithelial carcinoma10.2
36poland syndrome10.2
37pyoderma gangrenosum10.2
38apocrine adenosis of breast10.2
39breast cyst10.2
40breast mucinous carcinoma10.2
41breast myoepitheliosis10.2
42breast papillomatosis10.2
43breast secretory carcinoma10.2
44mastitis10.2
45neuroendocrine tumor10.2
46obesity10.2
47ovarian cyst10.2
48pyoderma10.2
49retinoblastoma10.2
50transitional cell carcinoma10.2

Graphical network of the top 20 diseases related to Ductal Carcinoma in Situ:



Diseases related to ductal carcinoma in situ

Clinical Features for Ductal Carcinoma in Situ

About this section

Drugs & Therapeutics for Ductal Carcinoma in Situ

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Ductal Carcinoma in Situ

Drug clinical trials:

Search ClinicalTrials for Ductal Carcinoma in Situ

Search NIH Clinical Center for Ductal Carcinoma in Situ

Search CenterWatch for Ductal Carcinoma in Situ

Genetic Tests for Ductal Carcinoma in Situ

About this section

Anatomical Context for Ductal Carcinoma in Situ

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Ductal Carcinoma in Situ:

32
Breast, Lymph node, Testes, Pancreas, Bone marrow, Bone, Smooth muscle, Cervix, Monocytes

Animal Models for Ductal Carcinoma in Situ or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Ductal Carcinoma in Situ:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6BNIP3, TIMP4, PGR, KRT14, ACTC1, BNIP3L
2MP:000200610.3TMEM158, ERBB2, KRT14, PGR, TFF1, CCND1

Publications for Ductal Carcinoma in Situ

About this section
Sources:
50PubMed
See all sources

Articles related to Ductal Carcinoma in Situ:

(show top 50)    (show all 725)
idTitleAuthorsYear
1
Time trends and inter-hospital variation in treatment and axillary staging of patients with ductal carcinoma in situ of the breast in the era of screening in Southern Netherlands. (24291376)
2014
2
Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. (23208501)
2013
3
Predictors of recurrence for ductal carcinoma in situ after breast-conserving surgery. (23896274)
2013
4
Clinicopathological analysis of breast ductal carcinoma in situ with ALDH1-positive cancer stem cells. (24192633)
2013
5
The management of ductal carcinoma in situ: current controversies and future directions. (23453783)
2013
6
Ductal carcinoma inA situ arising in tubular adenoma of the breast. (22700460)
2012
7
Adjuvant hormonal therapy use among women with ductal carcinoma in situ. (21902542)
2012
8
A rare case of extensive ductal carcinoma in situ of the breast with secretory features. (23372916)
2012
9
Coexisting ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer. (21983862)
2012
10
Conservative treatment of breast ductal carcinoma in situ: results of an Italian multi-institutional retrospective study. (23098066)
2012
11
Asymptomatic Incidental Ductal Carcinoma in situ in a Male Breast Presenting with Contralateral Gynecomastia. (22530182)
2012
12
Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression. (22342935)
2012
13
Ductal carcinoma in situ of the breast. (22378935)
2012
14
Mucocele-like tumor associated with ductal carcinoma in situ diagnosed as mucinous carcinoma by fine-needle aspiration cytology: report of a case. (22237901)
2012
15
Is ductal carcinoma in situ with "possible invasion" more predictive of invasive carcinoma than pure ductal carcinoma in situ? (21561735)
2012
16
Ductal carcinoma in situ at core-needle biopsy: meta-analysis of underestimation and predictors of invasive breast cancer. (21493791)
2011
17
Utility of cytokeratin 5/6 and high-molecular-weight keratin in evaluation of cauterized surgical margins in excised specimens of breast ductal carcinoma in situ. (21420886)
2011
18
Outcome of long term active surveillance for estrogen receptor-positive ductal carcinoma in situ. (21843942)
2011
19
Disparities in reconstruction rates after mastectomy for ductal carcinoma in situ (DCIS): patterns of care and factors associated with the use of breast reconstruction for DCIS compared with invasive cancer. (21863363)
2011
20
Dynamic MR findings of ductal carcinoma in situ within a fibroadenoma. (21720115)
2011
21
Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer. (21710692)
2011
22
Selective approach to radionuclide-guided sentinel lymph node biopsy in high-risk ductal carcinoma in situ of the breast. (21862942)
2011
23
Structural estimates of treatment effects on outcomes using retrospective data: an application to ductal carcinoma in situ. (21602195)
2011
24
Mammographycally occult high grade ductal carcinoma in situ (DCIS) as second primary breast cancer, detected with MRI: a case report. (22933920)
2010
25
Proceedings of the National Institutes of Health State-of-the-Science Conference, Diagnosis and Management of Ductal Carcinoma In Situ. September 2009. (21312388)
2010
26
Status of Intraductal Therapy for Ductal Carcinoma in Situ. (21124756)
2010
27
Epidemiology of ductal carcinoma in situ. (20956818)
2010
28
The use of sentinel lymph node biopsy in ductal carcinoma in situ. (20836339)
2010
29
Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer. (20105298)
2010
30
Lesion size is a major determinant of the mammographic features of ductal carcinoma in situ: findings from the Sloane project. (20152272)
2010
31
Biomarkers predicting recurrence and progression of ductal carcinoma in situ treated by lumpectomy alone. (20427432)
2010
32
Reproducibility of three classification systems of ductal carcinoma in situ of the breast using a web-based survey. (20663616)
2010
33
The impact of sentinel lymph node biopsy in patients with a core biopsy diagnosis of ductal carcinoma inA situ. (19756924)
2010
34
Ductal carcinoma in situ: dilemma or denouement. (20368539)
2010
35
Treatment of ductal carcinoma in situ among patients cared for in large integrated health plans. (20469955)
2010
36
Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome. (19729831)
2009
37
P-cadherin and cytokeratin 5: useful adjunct markers to distinguish basal-like ductal carcinomas in situ. (17123107)
2007
38
The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue. (17126249)
2006
39
Synchronous bilateral ductal carcinoma in situ of the male breast associated with gynecomastia in a 30-year-old patient following repeated injections of stanozolol. (16328719)
2006
40
Angiogenic potential of ductal carcinoma in situ (DCIS) of human breast. (16324200)
2005
41
Expression patterns of angiogenic and lymphangiogenic factors in ductal breast carcinoma in situ. (15841074)
2005
42
The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast: a study of a large cohort of patients treated with surgery alone. (15160334)
2004
43
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast. (12016391)
2002
44
Invasive ductal carcinoma of the breast: study of the number of copies of the CCND1 gene and chromosome 11 using fluorescence in situ hybridization (FISH) in comparison with expression of cyclin D1 protein and estrogen receptors (ER alpha) with immunohistochemical detection]. (12532908)
2002
45
Methylation in the p53 promoter is a supplementary route to breast carcinogenesis: correlation between CpG methylation in the p53 promoter and the mutation of the p53 gene in the progression from ductal carcinoma in situ to invasive ductal carcinoma. (11304577)
2001
46
Aberrant expression of MUC1 mucin in ductal hyperplasia and ductal carcinoma In situ of the breast. (10502721)
1999
47
Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23. (10458905)
1999
48
High levels of allele loss at the FHIT and ATM genes in non-comedo ductal carcinoma in situ and grade I tubular invasive breast cancers. (8968105)
1996
49
Ideas in pathology. Ductal carcinoma in situ of the breast: a proposal for a new simplified histological classification association between cellular proliferation and c-erbB-2 protein expression. (7911998)
1994
50
The classification of ductal carcinoma in situ and its association with biological markers. (7831531)
1994

Genetic Variations for Ductal Carcinoma in Situ

About this section

Expression for genes affiliated with Ductal Carcinoma in Situ

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ductal Carcinoma in Situ

Search GEO for disease gene expression data for Ductal Carcinoma in Situ.

Pathways for genes affiliated with Ductal Carcinoma in Situ

About this section
Sources:
51QIAGEN, 37NCBI BioSystems Database, 53Reactome
See all sources

Compounds for genes affiliated with Ductal Carcinoma in Situ

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.1CCND1, TFF1, PIP, PGR, TAS2R64P, MMP26
2paraffin4411.1CCND1, TFF1, PIP, PGR, KRT5, KRT14
3steroid4411.1KLK10, CCND1, TFF1, PIP, PGR, TAS2R64P
4retinoic acid44 2412.0CCND1, S100A7, TFF1, PGR, MMP26, KRT5
5testosterone44 59 11 2414.0CCND1, TFF1, PIP, PGR, KRT5, ACTC1
6tamoxifen44 49 28 1114.0CCND1, TFF1, PIP, PGR, KRT14, ERBB2
7progestins4411.0KLK10, CCND1, TFF1, PIP, PGR
8retinoid4411.0CCND1, TFF1, PGR, KRT5, KRT14
94-hydroxytamoxifen4411.0CCND1, TFF1, PGR, ERBB2
10progestin4410.9CCND1, TFF1, PGR, ERBB2
11mucicarmine4410.9ACTC1, KRT14, PIP
12lapatinib44 49 1112.9ERBB2, PGR, CCND1
13estrogen4410.9S100A7
14resveratrol44 59 11 2413.9CCND1, TFF1, PGR, ERBB2
15toremifene44 1111.9TFF1, PGR, ERBB2
16fulvestrant44 49 28 1113.9ERBB2, PGR, TFF1
17letrozole44 49 59 1113.9ERBB2, PGR, TFF1
18genistein44 28 59 2 11 2415.9CCND1, TFF1, PGR, KRT5, ERBB2
19estradiol44 11 2412.9MMP26, PGR, PIP, TFF1, CCND1
20vegf4410.9BNIP3, CCND1, TFF1, PGR, ACTC1, ERBB2
21arzoxifene4410.8TFF1, CCND1
22dihydrotestosterone44 28 11 2413.8KLK10, PIP, PGR
23genistin 2 4411.8TFF1, CCND1
24trastuzumab44 49 1112.8ERBB2, PGR, CCND1
25norgestrel4410.8PGR, KLK10
26hematoxylin4410.8TFF1, KRT14, ACTC1
27paclitaxel44 49 1112.8ERBB2, PGR, CCND1, BNIP3
28gemcitabine44 49 1112.7BNIP3, CCND1, ERBB2
29geldanamycin44 49 59 1113.7CCND1, PGR, ERBB2
30calcium44 49 11 2413.6S100A7, TFF1, HCLS1, MMP26, KRT5, KRT14
312-methoxyethanol4410.6ACTC1, KRT14
32everolimus49 44 1112.6CCND1, ERBB2
33megestrol acetate4410.5ERBB2, PGR
34anastrozole44 1111.4PGR, ERBB2
35capecitabine44 49 1112.2ERBB2, PGR

GO Terms for genes affiliated with Ductal Carcinoma in Situ

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00574110.5PGR, BNIP3, BNIP3L

Biological processes related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:03158110.5KRT14, KRT5
2mitochondrial protein catabolic processGO:03569410.5BNIP3, BNIP3L
3epidermis developmentGO:00854410.4KRT14, KRT5, S100A7
4response to iron ionGO:01003910.2TFF1, CCND1

Molecular functions related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.7ERBB2, BNIP3, CCND1, S100A7, TFF1, HCLS1

Products for genes affiliated with Ductal Carcinoma in Situ

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ductal Carcinoma in Situ

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet