MCID: DCT002
MIFTS: 46

Ductal Carcinoma in Situ malady

Cancer diseases category

Summaries for Ductal Carcinoma in Situ

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mammary ductal carcinoma is the most common type of breast cancer in women. It comes in two forms:... more...

MalaCards: Ductal Carcinoma in Situ is related to breast cancer and papilloma. An important gene associated with Ductal Carcinoma in Situ is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are Akt Signaling and GPCR Pathway. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and testes, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Ductal Carcinoma in Situ

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8Disease Ontology, 10DISEASES
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ductal carcinoma in situ 8 10


External Ids:

Disease Ontology8 DOID:0060074

Related Diseases for Ductal Carcinoma in Situ

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17GeneCards, 18GeneDecks
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Diseases related to Ductal Carcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.7CCND1, TFF1, PIP, PGR, KRT14, MST1R
2papilloma30.9ACTC1, KRT14, KRT5
3papillary carcinoma30.8ERBB2, ACTC1, KRT14, PGR
4squamous cell carcinoma30.3TFF1, S100A7, CCND1, KLK10, PIP, CLDN7
5inflammatory breast carcinoma30.3ERBB2, PGR
6hidradenoma30.3PIP
7in situ carcinoma11.6
8breast carcinoma in situ11.5
9breast disease10.7
10gynecomastia10.6
11comedo carcinoma10.6
12lymph node cancer10.6
13breast reconstruction10.5
14intraductal papilloma10.5
15neuroendocrine carcinoma10.5
16flat ductal epithelial atypia10.5
17breast papillary carcinoma10.5
18lobular neoplasia10.5
19breast apocrine carcinoma10.4
20breast apocrine carcinoma in situ10.4
21cribriform carcinoma10.3
22sclerosing adenosis of breast10.3
23bilateral breast cancer10.3
24breast intraductal proliferative lesion10.3
25prolactinoma10.2
26estrogen-receptor positive breast cancer10.2
27estrogen-receptor negative breast cancer10.2
28progesterone-receptor negative breast cancer10.2
29parathyroid carcinoma10.2
30breast adenomyoepithelioma10.2
31bone carcinoma10.2
32mccune albright syndrome10.2
33proteus syndrome10.2
34synchronous bilateral breast carcinoma10.2
35breast myoepithelial carcinoma10.2
36poland syndrome10.2
37pyoderma gangrenosum10.2
38apocrine adenosis of breast10.2
39breast cyst10.2
40breast mucinous carcinoma10.2
41breast myoepitheliosis10.2
42breast papillomatosis10.2
43breast secretory carcinoma10.2
44mastitis10.2
45neuroendocrine tumor10.2
46obesity10.2
47ovarian cyst10.2
48pyoderma10.2
49retinoblastoma10.2
50transitional cell carcinoma10.2

Graphical network of the top 20 diseases related to Ductal Carcinoma in Situ:



Diseases related to ductal carcinoma in situ

Clinical Features for Ductal Carcinoma in Situ

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Drugs & Therapeutics for Ductal Carcinoma in Situ

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Ductal Carcinoma in Situ

Search NIH Clinical Center for Ductal Carcinoma in Situ

Search CenterWatch for Ductal Carcinoma in Situ

Genetic Tests for Ductal Carcinoma in Situ

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Anatomical Context for Ductal Carcinoma in Situ

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32MalaCards
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MalaCards organs/tissues related to Ductal Carcinoma in Situ:

32
Breast, Lymph node, Testes, Pancreas, Bone marrow, Bone, Smooth muscle, Cervix, Monocytes

Animal Models for Ductal Carcinoma in Situ or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ductal Carcinoma in Situ:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6BNIP3, TIMP4, PGR, KRT14, ACTC1, BNIP3L
2MP:000200610.3TMEM158, ERBB2, KRT14, PGR, TFF1, CCND1

Publications for Ductal Carcinoma in Situ

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50PubMed
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Articles related to Ductal Carcinoma in Situ:

(show top 50)    (show all 725)
idTitleAuthorsYear
1
The frequency of presentation and clinico-pathological characteristics of symptomatic versus screen detected ductal carcinoma in situ of the breast. (24433818)
2014
2
Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS). (24346130)
2014
3
Predictors of Treatment with Mastectomy, Use of Sentinel Lymph Node Biopsy and Upstaging to Invasive Cancer in Patients Diagnosed with Breast Ductal Carcinoma In situ (DCIS) on Core Biopsy. (24046105)
2014
4
Impact of ductal carcinoma in situ terminology on patient treatment preferences. (23978843)
2013
5
The penetrance of ductal carcinoma in situ among BRCA1 and BRCA2 mutation carriers. (23184082)
2013
6
Prospective multicenter trial evaluating balloon-catheter partial-breast irradiation for ductal carcinoma in situ. (24074922)
2013
7
Adenomyoepithelioma with ductal carcinoma in situ: a case report and review of the literature. (23533914)
2013
8
Overexpression of Aldo-keto reductase family 1 B10 protein in ductal carcinoma in situ of the breast correlates with HER2 positivity. (23912490)
2013
9
A validation study of quantum dot multispectral imaging to evaluate hormone receptor status in ductal carcinoma in situ of the breast. (23039940)
2013
10
Nomogram for predicting invasion in patients with a preoperative diagnosis of ductal carcinoma in situ of the breast. (24227361)
2013
11
Incidence and consequence of close margins in patients with ductal carcinoma-in situ treated with mastectomy: is further therapy warranted? (23975313)
2013
12
Ductal carcinoma in situ with isolated tumor cells in the sentinel lymph node in a 17-year-old adolescent girl. (20411367)
2013
13
Does the volume of ductal carcinoma in situ impact the positive margin rate in patients undergoing breast conservation for invasive breast cancer? (23688789)
2013
14
Grade of ductal carcinoma in situ accompanying infiltrating ductal carcinoma as an independent prognostic factor. (23870857)
2013
15
Breast cancer and ductal carcinoma in situ among women with prior squamous or glandular precancer in the cervix: a register-based study. (23011481)
2012
16
Transitions between flat epithelial atypia and low-grade ductal carcinoma in situ of the breast. (22790863)
2012
17
Symmetry-based detection of ductal carcinoma in situ in breast MRI. (23083573)
2012
18
Ductal carcinoma in situ (DCIS): raising signposts on an ill-marked treatment path. (22491227)
2012
19
Increased breast density correlates with the proliferation-seeking radiotracer (99m)Tc(V)-DMSA uptake in florid epithelial hyperplasia and in mixed ductal carcinoma in situ with invasive ductal carcinoma but not in pure invasive ductal carcinoma or in mild epithelial hyperplasia. (21521552)
2011
20
Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma. (21088888)
2011
21
Differentiation between ductal carcinoma in situ and mastopathy using dynamic contrast-enhanced magnetic resonance imaging and a model of contrast enhancement. (21030170)
2011
22
Tamoxifen added to radiotherapy and surgery for the treatment of ductal carcinoma in situ of the breast: a meta-analysis of 2 randomized trials. (21411161)
2011
23
Ductal carcinoma in situ treated with breast-conserving surgery and accelerated partial breast irradiation: comparison of the Mammosite registry trial with intergroup study E5194. (21381007)
2011
24
Selection of treatment among Latina and non-Latina white women with ductal carcinoma in situ. (21128819)
2011
25
Knowledge, satisfaction with information, decisional conflict and psychological morbidity amongst women diagnosed with ductal carcinoma in situ (DCIS). (20696544)
2011
26
Oncoplastic surgery combining partial mastectomy with breast reconstruction using a free nipple-areola graft for ductal carcinoma in situ in a ptotic breast: report of a case. (21365421)
2011
27
Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model. (22025213)
2011
28
National Institutes of Health State-of-the-Science Conference statement: Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009. (20071686)
2010
29
Imaging for the diagnosis and management of ductal carcinoma in situ. (20956833)
2010
30
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer. (20056007)
2010
31
Ultrasound findings and histological features of ductal carcinoma in situ detected by ultrasound examination alone. (19575283)
2010
32
Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. (20427430)
2010
33
Relationship between clinical and pathologic features of ductal carcinoma in situ and patient age: an analysis of 657 patients. (19950406)
2009
34
Intracrinology of sex steroids in ductal carcinoma in situ (DCIS) of human breast: comparison to invasive ductal carcinoma (IDC) and non-neoplastic breast. (19444935)
2009
35
American Society of Breast Surgeons MammoSite Radiation Therapy System Registry Trial: ductal carcinoma-in-situ subset analysis--4-year data in 194 treated lesions. (19800456)
2009
36
Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ. (19689789)
2009
37
Parathyroid hormone-related protein protects against mammary tumor emergence and is associated with monocyte infiltration in ductal carcinoma in situ. (19723659)
2009
38
Study of matrix metalloproteinases and their tissue inhibitors in ductal in situ carcinomas of the breast. (18983606)
2008
39
Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. (17440163)
2007
40
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations. (16935972)
2006
41
HER2 status in pure ductal carcinoma in situ and in the intraductal and invasive components of invasive ductal carcinoma determined by fluorescence in situ hybridization and immunohistochemistry. (16681686)
2006
42
Incidence and clinical significance of lymph node metastasis detected by cytokeratin immunohistochemical staining in ductal carcinoma in situ. (15827818)
2005
43
p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2. (15318938)
2004
44
Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesis. (15564794)
2004
45
Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast. (12147647)
2002
46
Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. (11912139)
2002
47
Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. (11114859)
2000
48
The p53 tumor suppressor gene in ductal carcinoma in situ of the breast. (10623646)
2000
49
Immunohistochemical localisation of pS2 protein in ductal carcinoma in situ and benign lesions of the breast. (8385977)
1993
50
Estrogen receptors in ductal carcinoma in situ of breast. (2164337)
1990

Genetic Variations for Ductal Carcinoma in Situ

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Expression for genes affiliated with Ductal Carcinoma in Situ

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ductal Carcinoma in Situ

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Pathways for genes affiliated with Ductal Carcinoma in Situ

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Ductal Carcinoma in Situ

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.1CCND1, TFF1, PIP, PGR, TAS2R64P, MMP26
2paraffin4411.1CCND1, TFF1, PIP, PGR, KRT5, KRT14
3steroid4411.1KLK10, CCND1, TFF1, PIP, PGR, TAS2R64P
4retinoic acid44 2412.0CCND1, S100A7, TFF1, PGR, MMP26, KRT5
5testosterone44 59 11 2414.0CCND1, TFF1, PIP, PGR, KRT5, ACTC1
6tamoxifen44 49 28 1114.0CCND1, TFF1, PIP, PGR, KRT14, ERBB2
7progestins4411.0KLK10, CCND1, TFF1, PIP, PGR
8retinoid4411.0CCND1, TFF1, PGR, KRT5, KRT14
94-hydroxytamoxifen4411.0CCND1, TFF1, PGR, ERBB2
10progestin4410.9CCND1, TFF1, PGR, ERBB2
11mucicarmine4410.9ACTC1, KRT14, PIP
12lapatinib44 49 1112.9ERBB2, PGR, CCND1
13estrogen4410.9S100A7
14resveratrol44 59 11 2413.9CCND1, TFF1, PGR, ERBB2
15toremifene44 1111.9TFF1, PGR, ERBB2
16fulvestrant44 49 28 1113.9ERBB2, PGR, TFF1
17letrozole44 49 59 1113.9ERBB2, PGR, TFF1
18genistein44 28 59 2 11 2415.9CCND1, TFF1, PGR, KRT5, ERBB2
19estradiol44 11 2412.9MMP26, PGR, PIP, TFF1, CCND1
20vegf4410.9BNIP3, CCND1, TFF1, PGR, ACTC1, ERBB2
21arzoxifene4410.8TFF1, CCND1
22dihydrotestosterone44 28 11 2413.8KLK10, PIP, PGR
23genistin 2 4411.8TFF1, CCND1
24trastuzumab44 49 1112.8ERBB2, PGR, CCND1
25norgestrel4410.8PGR, KLK10
26hematoxylin4410.8TFF1, KRT14, ACTC1
27paclitaxel44 49 1112.8ERBB2, PGR, CCND1, BNIP3
28gemcitabine44 49 1112.7BNIP3, CCND1, ERBB2
29geldanamycin44 49 59 1113.7CCND1, PGR, ERBB2
30calcium44 49 11 2413.6S100A7, TFF1, HCLS1, MMP26, KRT5, KRT14
312-methoxyethanol4410.6ACTC1, KRT14
32everolimus49 44 1112.6CCND1, ERBB2
33megestrol acetate4410.5ERBB2, PGR
34anastrozole44 1111.4PGR, ERBB2
35capecitabine44 49 1112.2ERBB2, PGR

GO Terms for genes affiliated with Ductal Carcinoma in Situ

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16Gene Ontology
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Cellular components related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00574110.5PGR, BNIP3, BNIP3L

Biological processes related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:03158110.5KRT14, KRT5
2mitochondrial protein catabolic processGO:03569410.5BNIP3, BNIP3L
3epidermis developmentGO:00854410.4KRT14, KRT5, S100A7
4response to iron ionGO:01003910.2TFF1, CCND1

Molecular functions related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.7ERBB2, BNIP3, CCND1, S100A7, TFF1, HCLS1

Products for genes affiliated with Ductal Carcinoma in Situ

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Sources for Ductal Carcinoma in Situ

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet