MCID: DCT002
MIFTS: 41

Ductal Carcinoma in Situ malady

Cancer diseases category

Summaries for Ductal Carcinoma in Situ

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66Wikipedia, 34MalaCards
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Wikipedia:66 Ductal carcinoma in situ (DCIS), also known as intraductal carcinoma, is a precancerous lesion of the... more...

MalaCards: Ductal Carcinoma in Situ is related to breast cancer and papilloma. An important gene associated with Ductal Carcinoma in Situ is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2). The compounds megestrol acetate and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and testes, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Ductal Carcinoma in Situ

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9Disease Ontology, 11DISEASES
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ductal carcinoma in situ 9 11


External Ids:

Disease Ontology9 DOID:0060074

Related Diseases for Ductal Carcinoma in Situ

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18GeneCards, 19GeneDecks
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Diseases related to Ductal Carcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.6PGR, TFF1, ERBB2, KRT14
2papilloma30.9ACTC1, KRT14
3papillary carcinoma30.6PGR, KRT14, ERBB2, ACTC1
4gynecomastia10.7
5intraductal papilloma10.6
6breast reconstruction10.5
7lobular neoplasia10.5
8breast disease10.5
9hypoxia10.5
10mccune albright syndrome10.2
11poland syndrome10.2
12prolactinoma10.2
13pyoderma gangrenosum10.2
14proteus syndrome10.2
15comedo carcinoma10.2
16bilateral breast cancer10.2
17hidradenoma10.2
18mastitis10.2
19neuroendocrine tumor10.2
20obesity10.2
21ovarian cyst10.2
22pyoderma10.2
23retinoblastoma10.2
24phyllode tumor10.2
25breast fibroadenoma10.1PGR
26leiomyomatosis10.1PGR
27mammary paget's disease10.1PGR, ERBB2
28male breast cancer10.1PGR, ERBB2
29li-fraumeni syndrome10.1PGR, ERBB2
30inflammatory breast carcinoma10.1ERBB2, PGR
31endometrial carcinoma10.0ERBB2, PGR
32gastric adenocarcinoma10.0TFF1, CLDN7, ERBB2
33spindle cell carcinoma10.0ACTC1, PGR
34adenosarcoma10.0PGR, ACTC1
35endometrial stromal sarcoma10.0ACTC1, PGR
36angiomyolipoma10.0ACTC1, PGR
37smooth muscle tumor10.0PGR, ACTC1
38bladder carcinoma10.0ERBB2, ACTC1
39leiomyosarcoma10.0ACTC1, PGR
40oxyphilic adenoma10.0KRT14, CLDN7
41malignant mixed mullerian tumor10.0PGR, ACTC1, ERBB2
42tubular adenocarcinoma10.0PGR, ACTC1, ERBB2
43myoepithelioma10.0ACTC1, KRT14
44fibromatosis10.0TFF1, PGR, ACTC1
45leiomyoma10.0PGR, ACTC1
46ovarian cancer10.0ERBB2, PGR, TFF1
47angiosarcoma10.0ACTC1, KRT14
48squamous cell carcinoma of the head and neck10.0ERBB2, KRT14, CLDN7
49mucoepidermoid carcinoma10.0KRT14, ACTC1
50pleomorphic adenoma10.0ACTC1, ERBB2, KRT14

Graphical network of the top 20 diseases related to Ductal Carcinoma in Situ:



Diseases related to ductal carcinoma in situ

Symptoms for Ductal Carcinoma in Situ

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Drugs & Therapeutics for Ductal Carcinoma in Situ

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ductal Carcinoma in Situ

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Anatomical Context for Ductal Carcinoma in Situ

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34MalaCards
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MalaCards organs/tissues related to Ductal Carcinoma in Situ:

34
Breast, Lymph node, Testes, Bone, Bone marrow, Smooth muscle, Monocytes, Cervix

Animal Models for Ductal Carcinoma in Situ or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Ductal Carcinoma in Situ:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9TFF1, TNFRSF4, FOXC1, ERBB2, KRT14
2MP:00028738.4TNFRSF4, ERBB2, ACTC1, FOXC1, PGR
3MP:00107718.3FOXC1, KRT14, ERBB2, PGR, TFF1, CLDN7
4MP:00020068.3TFF1, KRT14, ERBB2, PGR, TMEM158
5MP:00053788.2KRT14, ERBB2, ACTC1, FOXC1, TNFRSF4, CLDN7
6MP:00053848.2ERBB2, ACTC1, FOXC1, PGR, TNFRSF4, KRT14
7MP:00053767.8PGR, KRT14, ERBB2, ACTC1, FOXC1, TFF1

Publications for Ductal Carcinoma in Situ

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53PubMed
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Articles related to Ductal Carcinoma in Situ:

(show top 50)    (show all 673)
idTitleAuthorsYear
1
Post-operative radiotherapy for ductal carcinoma in situ of the breast. (24259251)
2013
2
Patient, tumor and therapeutic features related to recurrence of ductal carcinoma in situ (DCIS). (24322025)
2013
3
Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. (23208501)
2013
4
US appearance of ductal carcinoma in situ. (23322838)
2013
5
Clinicopathologic features of ductal carcinoma in situ in young women with an emphasis on molecular subtype. (24029706)
2013
6
Factors influencing the quality of local management of ductal carcinoma in situ: a cohort study. (23737691)
2013
7
Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: a preclinical study. (23184608)
2013
8
Challenging paradigms: long non-coding RNAs in breast ductal carcinoma in situ (DCIS). (23577021)
2013
9
Molecular phenotypes of ductal carcinoma-in-situ and invasive ductal carcinoma: a comparative study. (22499299)
2012
10
Neuroendocrine ductal carcinoma in situ, comedo type, of the breast detected by screening mammography: a potentially pre-invasive counterpart of high grade neuroendocrine tumours. (22437750)
2012
11
Multi-institutional experience of ductal carcinoma in situ in black vs white patients treated with breast-conserving surgery and whole breast radiation therapy. (22672752)
2012
12
Predictors of invasive breast cancer and lymph node involvement in ductal carcinoma in situ initially diagnosed by vacuum-assisted breast biopsy: experience of 733 cases. (22795363)
2012
13
Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia. (22134623)
2012
14
ACR appropriateness criteria(Ar) ductal carcinoma in situ. (22107336)
2012
15
Cell polarity, epithelial-mesenchymal transition, and cell-fate decision gene expression in ductal carcinoma in situ. (22577534)
2012
16
Breast cancer and ductal carcinoma in situ among women with prior squamous or glandular precancer in the cervix: a register-based study. (23011481)
2012
17
Expression of HER2neu in ductal carcinoma in situ is associated with local recurrence. (21958729)
2012
18
Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. (21145284)
2011
19
Development and pilot testing of a communication aid to assist clinicians to communicate with women diagnosed with ductal carcinoma in situ (DCIS). (21088858)
2011
20
Intraoperative assessment of surgical margins during breast conserving surgery of ductal carcinoma in situ by use of radiofrequency spectroscopy. (21885281)
2011
21
Tissue microarray-based immunohistochemical study can significantly underestimate the expression of HER2 and progesterone receptor in ductal carcinoma in situ of the breast. (20701550)
2011
22
Ductal carcinoma in situ at core-needle biopsy: meta-analysis of underestimation and predictors of invasive breast cancer. (21493791)
2011
23
Mammographycally occult high grade ductal carcinoma in situ (DCIS) as second primary breast cancer, detected with MRI: a case report. (22933920)
2010
24
Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast. (20704578)
2010
25
Changes in invasive breast cancer and ductal carcinoma in situ rates in relation to the decline in hormone therapy use. (21060026)
2010
26
Ductal carcinoma in situ: terminology, classification, and natural history. (20956817)
2010
27
Proceedings of the National Institutes of Health State-of-the-Science Conference, Diagnosis and Management of Ductal Carcinoma In Situ. September 2009. (21312388)
2010
28
Quality-of-life issues in patients with ductal carcinoma in situ. (20956834)
2010
29
Coronal serial sequential sampling of breast specimen in the assessment of the extent of ductal carcinoma in situ. (19722734)
2009
30
Apocrine ductal carcinoma in situ involving a sclerosing lesion with adenosis: report of a case. (19886717)
2009
31
P63 and cytokeratin8/18 expression in breast, atypical ductal hyperplasia, ductal carcinoma in situ and invasive duct carcinoma. (19190693)
2007
32
Ductal carcinoma in situ in BRCA mutation carriers. (17210933)
2007
33
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast. (16807982)
2006
34
Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? (15832086)
2005
35
Incidence and clinical significance of lymph node metastasis detected by cytokeratin immunohistochemical staining in ductal carcinoma in situ. (15827818)
2005
36
Prevalence of BRCA1 and BRCA2 mutations in women diagnosed with ductal carcinoma in situ. (15728167)
2005
37
S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast. (15217497)
2004
38
p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2. (15318938)
2004
39
Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. (14717665)
2004
40
Evaluation of MUC1 splice variants as prognostic markers in patients with ductal carcinoma in situ of the breast. (14534730)
2003
41
Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast. (12147647)
2002
42
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast. (12016391)
2002
43
Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. (11912139)
2002
44
Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. (12434415)
2002
45
p53 missense mutations in microdissected high-grade ductal carcinoma in situ of the breast. (11333292)
2001
46
Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. (11381366)
2001
47
Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. (11114859)
2000
48
Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast. (9212742)
1997
49
Controversies in the treatment of ductal carcinoma in situ. (8610262)
1996
50
Immunohistochemical detection of oestrogen receptors in ductal carcinoma in situ of the breast. (9005143)
1996

Variations for Ductal Carcinoma in Situ

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Expression for genes affiliated with Ductal Carcinoma in Situ

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ductal Carcinoma in Situ

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Pathways for genes affiliated with Ductal Carcinoma in Situ

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Compounds for genes affiliated with Ductal Carcinoma in Situ

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1megestrol acetate4610.1ERBB2, PGR
2capecitabine46 52 1212.1PGR, ERBB2
3exemestane46 52 62 1213.1ERBB2, PGR
4anastrozole46 52 1212.1ERBB2, PGR
5lapatinib46 52 1212.0ERBB2, PGR
62-methoxyethanol4610.0ACTC1, KRT14
7mucicarmine4610.0ACTC1, KRT14
8bisphenol a4610.0TFF1, PGR
9taxane4610.0ERBB2, PGR
10steroidal469.9PGR, TFF1
11leucovorin46 52 1211.9PGR, ERBB2
12diethylstilbestrol46 30 1211.9PGR, TFF1
13toremifene46 1210.9ERBB2, PGR, TFF1
14fulvestrant46 52 30 1212.8ERBB2, PGR, TFF1
15letrozole46 52 62 1212.8TFF1, PGR, ERBB2
16progestins469.8PGR, TFF1
174-hydroxytamoxifen469.8TFF1, PGR, ERBB2
18progestin469.8ERBB2, PGR, TFF1
19resveratrol46 62 25 1212.8ERBB2, PGR, TFF1
20hematoxylin469.8KRT14, ACTC1, TFF1
21raloxifene46 52 30 1212.8ERBB2, PGR
22retinoid469.5KRT14, PGR, TFF1
23trastuzumab46 52 1211.5ERBB2, PGR
24tamoxifen46 52 30 1212.4TFF1, PGR, ERBB2, KRT14
25testosterone46 62 25 1212.4TFF1, PGR, ACTC1, ERBB2
26genistein46 30 62 3 25 1214.4TFF1, PGR, ERBB2
27dexamethasone46 52 30 1212.3TFF1, PGR, ACTC1, ERBB2
28cyclosporin a46 30 6211.3ACTC1, PGR, TNFRSF4
29vegf469.3TFF1, PGR, ACTC1, ERBB2
30paraffin469.1TFF1, PGR, ACTC1, ERBB2, KRT14
31estrogen469.0TFF1, PGR, ACTC1, ERBB2, KRT14
32retinoic acid46 2510.0TFF1, PGR, ACTC1, KRT14
33steroid468.9TAS2R64P, ERBB2, ACTC1, PGR, TFF1
34progesterone46 30 62 25 1212.6TAS2R64P, TFF1, PGR, ACTC1, ERBB2, KRT14

GO Terms for genes affiliated with Ductal Carcinoma in Situ

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Products for genes affiliated with Ductal Carcinoma in Situ

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Sources for Ductal Carcinoma in Situ

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet