MCID: DCT002
MIFTS: 46

Ductal Carcinoma in Situ malady

Cancer diseases category

Summaries for Ductal Carcinoma in Situ

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63Wikipedia, 32MalaCards
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Wikipedia:63 Mammary ductal carcinoma is the most common type of breast cancer in women. It comes in two forms:... more...

MalaCards: Ductal Carcinoma in Situ is related to breast cancer and papilloma. An important gene associated with Ductal Carcinoma in Situ is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2), and among its related pathways are Akt Signaling and GPCR Pathway. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and testes, and related mouse phenotypes are homeostasis/metabolism and tumorigenesis.

Aliases & Classifications for Ductal Carcinoma in Situ

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8Disease Ontology, 10DISEASES
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

ductal carcinoma in situ 8 10


External Ids:

Disease Ontology8 DOID:0060074

Related Diseases for Ductal Carcinoma in Situ

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17GeneCards, 18GeneDecks
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Diseases related to Ductal Carcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.7CCND1, TFF1, PIP, PGR, KRT14, MST1R
2papilloma30.9ACTC1, KRT14, KRT5
3papillary carcinoma30.8ERBB2, ACTC1, KRT14, PGR
4squamous cell carcinoma30.3TFF1, S100A7, CCND1, KLK10, PIP, CLDN7
5inflammatory breast carcinoma30.3ERBB2, PGR
6hidradenoma30.3PIP
7in situ carcinoma11.6
8breast carcinoma in situ11.5
9breast disease10.7
10gynecomastia10.6
11comedo carcinoma10.6
12lymph node cancer10.6
13breast reconstruction10.5
14intraductal papilloma10.5
15neuroendocrine carcinoma10.5
16flat ductal epithelial atypia10.5
17breast papillary carcinoma10.5
18lobular neoplasia10.5
19breast apocrine carcinoma10.4
20breast apocrine carcinoma in situ10.4
21cribriform carcinoma10.3
22sclerosing adenosis of breast10.3
23bilateral breast cancer10.3
24breast intraductal proliferative lesion10.3
25prolactinoma10.2
26estrogen-receptor positive breast cancer10.2
27estrogen-receptor negative breast cancer10.2
28progesterone-receptor negative breast cancer10.2
29parathyroid carcinoma10.2
30breast adenomyoepithelioma10.2
31bone carcinoma10.2
32mccune albright syndrome10.2
33proteus syndrome10.2
34synchronous bilateral breast carcinoma10.2
35breast myoepithelial carcinoma10.2
36poland syndrome10.2
37pyoderma gangrenosum10.2
38apocrine adenosis of breast10.2
39breast cyst10.2
40breast mucinous carcinoma10.2
41breast myoepitheliosis10.2
42breast papillomatosis10.2
43breast secretory carcinoma10.2
44mastitis10.2
45neuroendocrine tumor10.2
46obesity10.2
47ovarian cyst10.2
48pyoderma10.2
49retinoblastoma10.2
50transitional cell carcinoma10.2

Graphical network of the top 20 diseases related to Ductal Carcinoma in Situ:



Diseases related to ductal carcinoma in situ

Clinical Features for Ductal Carcinoma in Situ

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Drugs & Therapeutics for Ductal Carcinoma in Situ

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Ductal Carcinoma in Situ

Search NIH Clinical Center for Ductal Carcinoma in Situ

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Genetic Tests for Ductal Carcinoma in Situ

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Anatomical Context for Ductal Carcinoma in Situ

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32MalaCards
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MalaCards organs/tissues related to Ductal Carcinoma in Situ:

32
Breast, Lymph node, Testes, Pancreas, Bone marrow, Bone, Smooth muscle, Cervix, Monocytes

Animal Models for Ductal Carcinoma in Situ or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ductal Carcinoma in Situ:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.6BNIP3, TIMP4, PGR, KRT14, ACTC1, BNIP3L
2MP:000200610.3TMEM158, ERBB2, KRT14, PGR, TFF1, CCND1

Publications for Ductal Carcinoma in Situ

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50PubMed
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Articles related to Ductal Carcinoma in Situ:

(show top 50)    (show all 725)
idTitleAuthorsYear
1
Cosmesis Outcomes for Sector Resection for Ductal Carcinoma In Situ (DCIS). (24380921)
2014
2
MarginProbe(Ar) - Final results of the German post-market study in breast conserving surgery of ductal carcinoma in situ. (24291375)
2014
3
US appearance of ductal carcinoma in situ. (23322838)
2013
4
A review of the management of ductal carcinoma in situ following breast conserving surgery. (24070852)
2013
5
Role of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ. (24025166)
2013
6
Risk factors for non-invasive and invasive local recurrence in patients with ductal carcinoma in situ. (23624751)
2013
7
Molecular subtypes of ductal carcinoma in situ in African American and Caucasian American women: distribution and correlation with pathological features and outcome. (23639792)
2013
8
Extensive pure ductal carcinoma in situ of the breast: Identification of predictors of associated infiltrating carcinoma and lymph node metastasis before immediate reconstructive surgery. (24388733)
2013
9
Patient age and tumor size determine the cancer yield of preoperative bilateral breast MRI in women with ductal carcinoma in situ. (23971464)
2013
10
Ductal carcinoma in situ: an overview. (23984897)
2013
11
Opportunities for molecular epidemiological research on ductal carcinoma in-situ and breast carcinogenesis: Interdisciplinary approaches. (24225267)
2013
12
Ductal carcinoma in situ: a rose by any other name. (24068770)
2013
13
Next-generation sequencing: a powerful tool for the discovery of molecular markers in breast ductal carcinoma in situ. (23477556)
2013
14
Ductal carcinoma in situ associated with triple negative invasive breast cancer: evidence for a precursor-product relationship. (23539741)
2013
15
Pathological controversies in breast cancer: classification of ductal carcinoma in situ, sentinel lymph nodes and low volume metastatic disease and reporting of neoadjuvant chemotherapy specimens. (23199579)
2013
16
MicroRNA-132 is frequently down-regulated in ductal carcinoma in situ (DCIS) of breast and acts as a tumor suppressor by inhibiting cell proliferation. (23399321)
2013
17
Should axillary ultrasound be used in patients with a preoperative diagnosis of ductal carcinoma in situ? (22749764)
2012
18
Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision. (22253459)
2012
19
The role of breast MR imaging in pre-operative determination of invasive disease for ductal carcinoma in situ diagnosed by needle biopsy. (22205445)
2012
20
Multicentric and contralateral invasive tumors identified with pre-op MRI in patients newly diagnosed with ductal carcinoma in situ of the breast. (22804792)
2012
21
Comparison of the underestimation rate in cases with ductal carcinoma in situ at ultrasound-guided core biopsy: 14-gauge automated core-needle biopsy vs 8- or 11-gauge vacuum-assisted biopsy. (22422382)
2012
22
Validation of a nomogram for predicting risk of local recurrence for ductal carcinoma in situ. (22826276)
2012
23
Biologic features and prognosis of ductal carcinoma in situ are not adversely impacted by initial large body mass. (22392043)
2012
24
Intraoperative assessment of surgical margins during breast conserving surgery of ductal carcinoma in situ by use of radiofrequency spectroscopy. (21885281)
2011
25
Breast density, scintimammographic (99m)Tc(V)DMSA uptake, and calcitonin gene related peptide (CGRP) expression in mixed invasive ductal associated with extensive inA situ ductal carcinoma (IDCA +A DCIS) and pure invasive ductal carcinoma (IDC): correlation with estrogen receptor (ER) status, proliferation index Ki-67, and histological grade. (20143189)
2011
26
The influence of clinicopathological features on the predictive accuracy of conventional breast imaging in determining the extent of screen-detected high-grade pure ductal carcinoma in situ. (21943463)
2011
27
Synchronous benign-appearing calcifications in patients with ductal carcinoma in situ may not be benign. (20602184)
2011
28
Her-2 positive ductal carcinoma in situ is an independent predictor of tumor recurrence. (21805692)
2011
29
Accelerated partial breast irradiation for pure ductal carcinoma in situ. (20800374)
2011
30
Outcomes of screening-detected ductal carcinoma in situ treated with wide excision alone. (21630124)
2011
31
Ductal carcinoma in situ: terminology, classification, and natural history. (20956817)
2010
32
The use of oncoplastic reduction techniques to reconstruct partial mastectomy defects in women with ductal carcinoma in situ. (20102367)
2010
33
Micropapillary ductal carcinoma in situ of the breast: an inter-institutional study. (19915523)
2010
34
Predictors of invasive breast cancer in ductal carcinoma in situ initially diagnosed by core biopsy. (21029943)
2010
35
Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events. (20127359)
2010
36
Apocrine ductal carcinoma in situ involving a sclerosing lesion with adenosis: report of a case. (19886717)
2009
37
Expression of cytokeratin markers, ER-alpha, PR, HER-2/neu, and EGFR in pure ductal carcinoma in situ (DCIS) and DCIS with co-existing invasive ductal carcinoma (IDC) of the breast. (17522367)
2007
38
The receptor expression pattern in ductal carcinoma in situ predicts recurrence. (16769278)
2006
39
Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity. (17060931)
2006
40
Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? (15832086)
2005
41
Prevalence of BRCA1 and BRCA2 mutations in women diagnosed with ductal carcinoma in situ. (15728167)
2005
42
An in situ carcinoma of the pancreas forming 2 invasive ductal carcinomas. (16025010)
2005
43
Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation. (15528970)
2004
44
Tissue microarray analyses of G1/S-regulatory proteins in ductal carcinoma in situ of the breast indicate that low cyclin D1 is associated with local recurrence. (14612904)
2003
45
Oestrogen receptor negativity as a marker for high-grade ductal carcinoma in situ of the breast. (12713620)
2003
46
Thymidine phosphorylase expression and stromal vascularity in ductal carcinoma in situ of the breast. (14645350)
2003
47
Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. (11381366)
2001
48
Cyclin D1 gene amplification and overexpression are present in ductal carcinoma in situ of the breast. (10398079)
1999
49
Microsatellite instability in ductal carcinoma in situ of the breast. (9713355)
1998
50
Up-regulation of thymidine phosphorylase expression is associated with a discrete pattern of angiogenesis in ductal carcinomas in situ of the breast. (9306962)
1997

Genetic Variations for Ductal Carcinoma in Situ

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Expression for genes affiliated with Ductal Carcinoma in Situ

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ductal Carcinoma in Situ

Search GEO for disease gene expression data for Ductal Carcinoma in Situ.

Pathways for genes affiliated with Ductal Carcinoma in Situ

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51QIAGEN, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Ductal Carcinoma in Situ

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.1CCND1, TFF1, PIP, PGR, TAS2R64P, MMP26
2paraffin4411.1CCND1, TFF1, PIP, PGR, KRT5, KRT14
3steroid4411.1KLK10, CCND1, TFF1, PIP, PGR, TAS2R64P
4retinoic acid44 2412.0CCND1, S100A7, TFF1, PGR, MMP26, KRT5
5testosterone44 59 11 2414.0CCND1, TFF1, PIP, PGR, KRT5, ACTC1
6tamoxifen44 49 28 1114.0CCND1, TFF1, PIP, PGR, KRT14, ERBB2
7progestins4411.0KLK10, CCND1, TFF1, PIP, PGR
8retinoid4411.0CCND1, TFF1, PGR, KRT5, KRT14
94-hydroxytamoxifen4411.0CCND1, TFF1, PGR, ERBB2
10progestin4410.9CCND1, TFF1, PGR, ERBB2
11mucicarmine4410.9ACTC1, KRT14, PIP
12lapatinib44 49 1112.9ERBB2, PGR, CCND1
13estrogen4410.9S100A7
14resveratrol44 59 11 2413.9CCND1, TFF1, PGR, ERBB2
15toremifene44 1111.9TFF1, PGR, ERBB2
16fulvestrant44 49 28 1113.9ERBB2, PGR, TFF1
17letrozole44 49 59 1113.9ERBB2, PGR, TFF1
18genistein44 28 59 2 11 2415.9CCND1, TFF1, PGR, KRT5, ERBB2
19estradiol44 11 2412.9MMP26, PGR, PIP, TFF1, CCND1
20vegf4410.9BNIP3, CCND1, TFF1, PGR, ACTC1, ERBB2
21arzoxifene4410.8TFF1, CCND1
22dihydrotestosterone44 28 11 2413.8KLK10, PIP, PGR
23genistin 2 4411.8TFF1, CCND1
24trastuzumab44 49 1112.8ERBB2, PGR, CCND1
25norgestrel4410.8PGR, KLK10
26hematoxylin4410.8TFF1, KRT14, ACTC1
27paclitaxel44 49 1112.8ERBB2, PGR, CCND1, BNIP3
28gemcitabine44 49 1112.7BNIP3, CCND1, ERBB2
29geldanamycin44 49 59 1113.7CCND1, PGR, ERBB2
30calcium44 49 11 2413.6S100A7, TFF1, HCLS1, MMP26, KRT5, KRT14
312-methoxyethanol4410.6ACTC1, KRT14
32everolimus49 44 1112.6CCND1, ERBB2
33megestrol acetate4410.5ERBB2, PGR
34anastrozole44 1111.4PGR, ERBB2
35capecitabine44 49 1112.2ERBB2, PGR

GO Terms for genes affiliated with Ductal Carcinoma in Situ

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16Gene Ontology
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Cellular components related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:00574110.5PGR, BNIP3, BNIP3L

Biological processes related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemidesmosome assemblyGO:03158110.5KRT14, KRT5
2mitochondrial protein catabolic processGO:03569410.5BNIP3, BNIP3L
3epidermis developmentGO:00854410.4KRT14, KRT5, S100A7
4response to iron ionGO:01003910.2TFF1, CCND1

Molecular functions related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.7ERBB2, BNIP3, CCND1, S100A7, TFF1, HCLS1

Products for genes affiliated with Ductal Carcinoma in Situ

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Sources for Ductal Carcinoma in Situ

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet