MCID: DCT002
MIFTS: 42

Ductal Carcinoma in Situ malady

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Summaries for Ductal Carcinoma in Situ

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Wikipedia:65 Ductal carcinoma in situ (DCIS), also known as intraductal carcinoma, is referred a pre-cancerous or... more...

MalaCards based summary: Ductal Carcinoma in Situ is related to breast ductal carcinoma and breast cancer. An important gene associated with Ductal Carcinoma in Situ is ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2). The compounds megestrol acetate and capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and testes, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Ductal Carcinoma in Situ

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Ductal Carcinoma in Situ, Aliases & Descriptions:

Name: Ductal Carcinoma in Situ 8 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:0060074

Related Diseases for Ductal Carcinoma in Situ

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Diseases related to Ductal Carcinoma in Situ via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1breast ductal carcinoma31.6TFF1, PGR, ERBB2
2breast cancer31.4TFF1, PGR, ERBB2, KRT14
3papilloma30.5ACTC1, KRT14
4papillary carcinoma30.2PGR, ACTC1, ERBB2, KRT14
5gynecomastia10.7
6intraductal papilloma10.6
7lobular neoplasia10.6
8breast reconstruction10.6
9breast disease10.5
10hypoxia10.5
11breast fibroadenoma10.4PGR
12leiomyomatosis10.4PGR
13mammary paget's disease10.3PGR, ERBB2
14male breast cancer10.3PGR, ERBB2
15obesity10.3
16mccune albright syndrome10.3
17poland syndrome10.3
18proteus syndrome10.3
19comedo carcinoma10.3
20prolactinoma10.3
21pyoderma gangrenosum10.3
22bilateral breast cancer10.3
23hidradenoma10.3
24mastitis10.3
25neuroendocrine tumor10.3
26ovarian cyst10.3
27pyoderma10.3
28retinoblastoma10.3
29phyllode tumor10.3
30li-fraumeni syndrome10.2PGR, ERBB2
31inflammatory breast carcinoma10.2PGR, ERBB2
32endometrial carcinoma10.2ERBB2, PGR
33gastric adenocarcinoma10.1ERBB2, CLDN7, TFF1
34spindle cell carcinoma10.1ACTC1, PGR
35adenosarcoma10.1PGR, ACTC1
36endometrial stromal sarcoma10.1PGR, ACTC1
37angiomyolipoma10.1PGR, ACTC1
38smooth muscle tumor10.1ACTC1, PGR
39bladder carcinoma10.1ERBB2, ACTC1
40leiomyosarcoma10.0ACTC1, PGR
41oxyphilic adenoma10.0KRT14, CLDN7
42malignant mixed mullerian tumor10.0PGR, ACTC1, ERBB2
43tubular adenocarcinoma10.0ERBB2, ACTC1, PGR
44myoepithelioma10.0KRT14, ACTC1
45fibromatosis10.0ACTC1, PGR, TFF1
46leiomyoma10.0ACTC1, PGR
47ovarian cancer9.9ERBB2, PGR, TFF1
48angiosarcoma9.9KRT14, ACTC1
49squamous cell carcinoma of the head and neck9.9KRT14, ERBB2, CLDN7
50mucoepidermoid carcinoma9.9ACTC1, KRT14

Graphical network of the top 20 diseases related to Ductal Carcinoma in Situ:



Diseases related to ductal carcinoma in situ

Symptoms for Ductal Carcinoma in Situ

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Drugs & Therapeutics for Ductal Carcinoma in Situ

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Drug clinical trials:

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Genetic Tests for Ductal Carcinoma in Situ

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Anatomical Context for Ductal Carcinoma in Situ

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MalaCards organs/tissues related to Ductal Carcinoma in Situ:

32
Breast, Lymph node, Testes, Bone marrow, Bone, Smooth muscle, Salivary gland, Cervix, Monocytes

Animal Models for Ductal Carcinoma in Situ or affiliated genes

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MGI Mouse Phenotypes related to Ductal Carcinoma in Situ:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9TFF1, TNFRSF4, FOXC1, ERBB2, KRT14
2MP:00028738.4TNFRSF4, PGR, FOXC1, ACTC1, ERBB2
3MP:00107718.3KRT14, ERBB2, FOXC1, PGR, CLDN7, TFF1
4MP:00020068.3TFF1, TMEM158, PGR, ERBB2, KRT14
5MP:00053788.2KRT14, ERBB2, ACTC1, FOXC1, CLDN7, TNFRSF4
6MP:00053848.2TNFRSF4, PGR, FOXC1, ACTC1, ERBB2, KRT14
7MP:00053767.8TFF1, CLDN7, PGR, FOXC1, ACTC1, ERBB2

Publications for Ductal Carcinoma in Situ

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Articles related to Ductal Carcinoma in Situ:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast. (24948027)
2014
2
Molecular Pathology: SY18-1 MOLECULAR PROFILING OF BREAST DUCTAL CARCINOMA IN-SITU. (25188123)
2014
3
Post-operative radiotherapy for ductal carcinoma in situ of the breast. (24259251)
2013
4
Hypofractionated radiation therapy for breast ductal carcinoma in situ. (24113057)
2013
5
Patient, tumor and therapeutic features related to recurrence of ductal carcinoma in situ (DCIS). (24322025)
2013
6
Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. (23208501)
2013
7
US appearance of ductal carcinoma in situ. (23322838)
2013
8
Clinicopathologic features of ductal carcinoma in situ in young women with an emphasis on molecular subtype. (24029706)
2013
9
Factors influencing the quality of local management of ductal carcinoma in situ: a cohort study. (23737691)
2013
10
Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: a preclinical study. (23184608)
2013
11
Challenging paradigms: long non-coding RNAs in breast ductal carcinoma in situ (DCIS). (23577021)
2013
12
Molecular phenotypes of ductal carcinoma-in-situ and invasive ductal carcinoma: a comparative study. (22499299)
2012
13
Neuroendocrine ductal carcinoma in situ, comedo type, of the breast detected by screening mammography: a potentially pre-invasive counterpart of high grade neuroendocrine tumours. (22437750)
2012
14
Multi-institutional experience of ductal carcinoma in situ in black vs white patients treated with breast-conserving surgery and whole breast radiation therapy. (22672752)
2012
15
Predictors of invasive breast cancer and lymph node involvement in ductal carcinoma in situ initially diagnosed by vacuum-assisted breast biopsy: experience of 733 cases. (22795363)
2012
16
Progression of ductal carcinoma in situ to invasive breast cancer is associated with gene expression programs of EMT and myoepithelia. (22134623)
2012
17
ACR appropriateness criteria(Ar) ductal carcinoma in situ. (22107336)
2012
18
Cell polarity, epithelial-mesenchymal transition, and cell-fate decision gene expression in ductal carcinoma in situ. (22577534)
2012
19
Breast cancer and ductal carcinoma in situ among women with prior squamous or glandular precancer in the cervix: a register-based study. (23011481)
2012
20
Effect of tamoxifen and radiotherapy in women with locally excised ductal carcinoma in situ: long-term results from the UK/ANZ DCIS trial. (21145284)
2011
21
Development and pilot testing of a communication aid to assist clinicians to communicate with women diagnosed with ductal carcinoma in situ (DCIS). (21088858)
2011
22
Intraoperative assessment of surgical margins during breast conserving surgery of ductal carcinoma in situ by use of radiofrequency spectroscopy. (21885281)
2011
23
Tissue microarray-based immunohistochemical study can significantly underestimate the expression of HER2 and progesterone receptor in ductal carcinoma in situ of the breast. (20701550)
2011
24
Ductal carcinoma in situ at core-needle biopsy: meta-analysis of underestimation and predictors of invasive breast cancer. (21493791)
2011
25
Mammographycally occult high grade ductal carcinoma in situ (DCIS) as second primary breast cancer, detected with MRI: a case report. (22933920)
2010
26
Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast. (20704578)
2010
27
Changes in invasive breast cancer and ductal carcinoma in situ rates in relation to the decline in hormone therapy use. (21060026)
2010
28
Ductal carcinoma in situ: terminology, classification, and natural history. (20956817)
2010
29
Proceedings of the National Institutes of Health State-of-the-Science Conference, Diagnosis and Management of Ductal Carcinoma In Situ. September 2009. (21312388)
2010
30
Coronal serial sequential sampling of breast specimen in the assessment of the extent of ductal carcinoma in situ. (19722734)
2009
31
P63 and cytokeratin8/18 expression in breast, atypical ductal hyperplasia, ductal carcinoma in situ and invasive duct carcinoma. (19190693)
2007
32
Ductal carcinoma in situ in BRCA mutation carriers. (17210933)
2007
33
Expression of MT-1 MMP, MMP2, MMP9 and TIMP2 mRNAs in ductal carcinoma in situ and invasive ductal carcinoma of the breast. (16807982)
2006
34
Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? (15832086)
2005
35
Incidence and clinical significance of lymph node metastasis detected by cytokeratin immunohistochemical staining in ductal carcinoma in situ. (15827818)
2005
36
Prevalence of BRCA1 and BRCA2 mutations in women diagnosed with ductal carcinoma in situ. (15728167)
2005
37
S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast. (15217497)
2004
38
p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2. (15318938)
2004
39
Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. (14717665)
2004
40
Evaluation of MUC1 splice variants as prognostic markers in patients with ductal carcinoma in situ of the breast. (14534730)
2003
41
Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast. (12147647)
2002
42
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast. (12016391)
2002
43
Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. (11912139)
2002
44
Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. (12434415)
2002
45
p53 missense mutations in microdissected high-grade ductal carcinoma in situ of the breast. (11333292)
2001
46
Apocrine ductal carcinoma in situ of the breast: histologic classification and expression of biologic markers. (11381366)
2001
47
Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. (11114859)
2000
48
Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast. (9212742)
1997
49
Controversies in the treatment of ductal carcinoma in situ. (8610262)
1996
50
Immunohistochemical detection of oestrogen receptors in ductal carcinoma in situ of the breast. (9005143)
1996

Variations for Ductal Carcinoma in Situ

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Expression for genes affiliated with Ductal Carcinoma in Situ

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Expression patterns in normal tissues for genes affiliated with Ductal Carcinoma in Situ

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Pathways for genes affiliated with Ductal Carcinoma in Situ

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Compounds for genes affiliated with Ductal Carcinoma in Situ

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Compounds related to Ductal Carcinoma in Situ according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1megestrol acetate4410.1ERBB2, PGR
2capecitabine44 50 1112.1PGR, ERBB2
3exemestane44 50 61 1113.1ERBB2, PGR
4anastrozole44 50 1112.1ERBB2, PGR
5lapatinib44 50 1112.0ERBB2, PGR
62-methoxyethanol4410.0ACTC1, KRT14
7mucicarmine4410.0ACTC1, KRT14
8bisphenol a4410.0TFF1, PGR
9taxane4410.0ERBB2, PGR
10steroidal449.9PGR, TFF1
11leucovorin44 50 1111.9PGR, ERBB2
12diethylstilbestrol44 28 1111.9PGR, TFF1
13toremifene44 1110.9ERBB2, PGR, TFF1
14fulvestrant44 50 28 1112.8ERBB2, PGR, TFF1
15letrozole44 50 61 1112.8TFF1, PGR, ERBB2
16progestins449.8PGR, TFF1
174-hydroxytamoxifen449.8TFF1, PGR, ERBB2
18progestin449.8ERBB2, PGR, TFF1
19resveratrol44 61 24 1112.8ERBB2, PGR, TFF1
20hematoxylin449.8KRT14, ACTC1, TFF1
21raloxifene44 50 28 1112.8ERBB2, PGR
22retinoid449.5KRT14, PGR, TFF1
23trastuzumab44 50 1111.5ERBB2, PGR
24tamoxifen44 50 28 1112.4TFF1, PGR, ERBB2, KRT14
25testosterone44 61 24 1112.4TFF1, PGR, ACTC1, ERBB2
26genistein44 28 61 2 24 1114.4TFF1, PGR, ERBB2
27dexamethasone44 50 28 1112.3TFF1, PGR, ACTC1, ERBB2
28cyclosporin a44 28 6111.3ACTC1, PGR, TNFRSF4
29vegf449.3TFF1, PGR, ACTC1, ERBB2
30paraffin449.1TFF1, PGR, ACTC1, ERBB2, KRT14
31estrogen449.0TFF1, PGR, ACTC1, ERBB2, KRT14
32retinoic acid44 2410.0TFF1, PGR, ACTC1, KRT14
33steroid448.9TAS2R64P, ERBB2, ACTC1, PGR, TFF1
34progesterone44 28 61 24 1112.6TAS2R64P, TFF1, PGR, ACTC1, ERBB2, KRT14

GO Terms for genes affiliated with Ductal Carcinoma in Situ

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Products for genes affiliated with Ductal Carcinoma in Situ

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Sources for Ductal Carcinoma in Situ

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet