MCID: DDN009
MIFTS: 34

Duodenal Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenal Obstruction

MalaCards integrated aliases for Duodenal Obstruction:

Name: Duodenal Obstruction 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3558
ICD10 32 K31.5
MeSH 41 D004380
NCIt 46 C79548
SNOMED-CT 64 95532008
UMLS 69 C0013292

Summaries for Duodenal Obstruction

MalaCards based summary : Duodenal Obstruction is related to lacrimoauriculodentodigital syndrome and duodenitis. An important gene associated with Duodenal Obstruction is HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta). The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Duodenal Obstruction

Diseases related to Duodenal Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 lacrimoauriculodentodigital syndrome 11.1
2 duodenitis 10.9
3 pancreatitis 10.4
4 pancreas, annular 10.3
5 aneurysm 10.3
6 aortic aneurysm 10.2
7 aortic aneurysm, familial abdominal, 1 10.2
8 gallbladder disease 1 10.2
9 situs inversus 10.1
10 pancreatic cancer 10.0
11 septopreoptic holoprosencephaly 10.0 CDON NODAL
12 midline interhemispheric variant of holoprosencephaly 10.0 CDON NODAL
13 microform holoprosencephaly 9.9 CDON NODAL
14 acute pancreatitis 9.9
15 duodenal disease 9.9 HLA-DOB NHS NODAL
16 alobar holoprosencephaly 9.9 CDON NODAL
17 fibrosis of extraocular muscles, congenital, 1 9.9
18 fibrosclerosis, multifocal 9.9
19 gastroenteritis 9.9
20 superior mesenteric artery syndrome 9.9
21 eosinophilic gastroenteritis 9.9
22 peritonitis 9.9
23 retroperitoneal fibrosis 9.9
24 lobar holoprosencephaly 9.8 CDON NODAL
25 down syndrome 9.8
26 bile duct cysts 9.8
27 appendicitis 9.8
28 streptococcal group a invasive disease 9.8
29 semilobar holoprosencephaly 9.8 CDON NODAL
30 congenital anomalies of kidney and urinary tract 2 9.7
31 intussusception 9.7
32 cerebral palsy 9.7
33 hepatitis 9.7
34 lymphoma 9.7
35 ileocolitis 9.7
36 omphalocele 9.7
37 blind loop syndrome 9.7
38 strongyloidiasis 9.7
39 sarcoma 9.7
40 cholestasis 9.7
41 obstructive jaundice 9.7
42 duodenal ulcer 9.7
43 adenocarcinoma 9.7
44 cerebritis 9.7
45 adenoma 9.7
46 gastroduodenitis 9.7
47 fibromatosis 9.7
48 isolated levocardia 9.7
49 levocardia 9.7
50 holoprosencephaly 9.6 CDON NODAL

Graphical network of the top 20 diseases related to Duodenal Obstruction:



Diseases related to Duodenal Obstruction

Symptoms & Phenotypes for Duodenal Obstruction

GenomeRNAi Phenotypes related to Duodenal Obstruction according to GeneCards Suite gene sharing:

25 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.66 NODAL
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.66 NDUFB4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 NDUFB4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.66 NODAL
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.66 FAM120A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.66 FAM120A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.66 NODAL
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.66 FAM120A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 NDUFB4 NODAL
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.66 NDUFB4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 FAM120A NDUFB4 NODAL
12 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.66 NDUFB4 NODAL
13 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.66 FAM120A NDUFB4
14 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.66 NODAL
15 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.66 FAM120A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 NDUFB4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.66 FAM120A

Drugs & Therapeutics for Duodenal Obstruction

Drugs for Duodenal Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
3
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
4
Ticlopidine Approved Phase 3 55142-85-3 5472
5 Analgesics Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Antacids Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Anti-Inflammatory Agents, Non-Steroidal Phase 3
10 Antipyretics Phase 3
11 Antirheumatic Agents Phase 3
12 Anti-Ulcer Agents Phase 3
13 Cyclooxygenase Inhibitors Phase 3
14 Cytochrome P-450 Enzyme Inhibitors Phase 3
15 Fibrinolytic Agents Phase 3
16 Gastrointestinal Agents Phase 3
17 Neurotransmitter Agents Phase 3
18 Peripheral Nervous System Agents Phase 3
19 Platelet Aggregation Inhibitors Phase 3
20 Proton pump inhibitors Phase 3
21 Purinergic P2 Receptor Antagonists Phase 3
22 Purinergic P2Y Receptor Antagonists Phase 3
23 Cola Nutraceutical Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
2 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
3 EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms Completed NCT00991614
4 SMAS: a Prospective Study in a Single Institution Completed NCT03416647
5 Comparison of Duodenal Stenting vs Transpyloric and Duodenal Stenting for Malignant Obstruction Recruiting NCT03125148
6 Endoscopic Gastroenteric Anastomosis With New Tissue Apposing Stent in the Management of Antro-pyloroduodenal Obstruction : Evaluation of Feasibility, Efficacy and Tolerance. Recruiting NCT02562157

Search NIH Clinical Center for Duodenal Obstruction

Cochrane evidence based reviews: duodenal obstruction

Genetic Tests for Duodenal Obstruction

Anatomical Context for Duodenal Obstruction

MalaCards organs/tissues related to Duodenal Obstruction:

38
Pancreas, Colon, Kidney, Lung, T Cells, Liver, B Cells

Publications for Duodenal Obstruction

Articles related to Duodenal Obstruction:

(show top 50) (show all 555)
# Title Authors Year
1
Double Duodenal Atresia: An Extremely Rare Presentation of Duodenal Obstruction. ( 29314383 )
2018
2
International study of endoscopic management of distal malignant biliary obstruction combined with duodenal obstruction. ( 28982258 )
2018
3
Severe muscle fasciculations and tremor in a cat with hypochloraemic metabolic alkalosis secondary to duodenal obstruction. ( 28491446 )
2017
4
A unique complication of self-expandable metal stent placement in malignant duodenal obstruction. ( 28928926 )
2017
5
Laparoscopic versus open surgery in management of congenital duodenal obstruction in neonates: a single-center experience with 112 cases. ( 28943138 )
2017
6
Transition from Laparotomy to Laparoscopic Repair of Congenital Duodenal Obstruction in Neonates: Our Early Experience. ( 29018788 )
2017
7
Annular pancreas causing duodenal obstruction in an adult. ( 28500113 )
2017
8
A case report of duodenal obstruction due to retroperitoneal bleeding after the rupture of a lower pancreaticoduodenal artery aneurysm. ( 28381781 )
2017
9
Roux-en-Y duodenojejunostomy for surgical management of isolated duodenal obstruction due to chronic pancreatitis. ( 28189119 )
2017
10
Congenital Duodenal Obstruction, Situs Inversus Totalis, and Gastric Perforation in a Neonate. ( 28770132 )
2017
11
A Rare Cause of Duodenal Obstruction: Metastatic Parotid Mucoepidermoid Carcinoma. ( 28351791 )
2017
12
Distal Duodenal Obstruction: a Surgical Enigma. ( 28659679 )
2017
13
Endoscopic biliary stent insertion through specialized duodenal stent for combined malignant biliary and duodenal obstruction facilitated by stent or PTBD guidance. ( 28685637 )
2017
14
Giant Omphalocele Complicated by Postoperative Duodenal Obstruction. ( 28164002 )
2017
15
Unexpected cause for duodenal obstruction: Brunner's gland hyperplasia. ( 29449737 )
2017
16
An Unusual Cause of Duodenal Obstruction: Persimmon Phytobezoar. ( 28100951 )
2016
17
Temporary duodenal stenting as a bridge to ERCP for inaccessible papilla due to duodenal obstruction: a retrospective study. ( 27652301 )
2016
18
Palliation double stenting for malignant biliary and duodenal obstruction. ( 26889267 )
2016
19
Randomized controlled exploratory study comparing the usefulness of two types of metallic stents with different axial forces for the management of duodenal obstruction caused by pancreatobiliary cancer. ( 26946214 )
2016
20
Congenital duodenal obstruction with delayed presentation: seven years of experience. ( 27695493 )
2016
21
Duodenal Obstruction on 99mTc-DISIDA Cholescintigraphy: A Noninvasive Approach to Bowel Obstruction Diagnosis. ( 27834726 )
2016
22
Is laparoscopic surgery better than open surgery for the repair of congenital duodenal obstruction? A review of the current evidences. ( 27622585 )
2016
23
Preduodenal Portal Vein Associated with Duodenal Obstruction of other Etiology: A Case Series. ( 27896162 )
2016
24
Association Between Prenatal Sonographic Findings of Duodenal Obstruction and Adverse Outcomes. ( 27466262 )
2016
25
Endoscopic choledochoduodenostomy and gastrojejunostomy in the treatment of biliary and duodenal obstruction. ( 26684602 )
2016
26
Laparoscopic repair of congenital duodenal obstruction is feasible even in small-volume centres. ( 27652789 )
2016
27
Congenital duodenal obstruction: causes and imaging approach. ( 27324508 )
2016
28
The role of palliative surgery in the management of advanced pancreatic cancer in patients with biliary and duodenal obstruction. ( 26868166 )
2016
29
Intestinal malrotation associated with duodenal obstruction secondary to Ladd's bands. ( 27777485 )
2016
30
Single-session double-stent placement in concomitant malignant biliary and duodenal obstruction with a cautery-tipped lumen apposing metal stent. ( 27706541 )
2016
31
Congenital Duodenal Obstruction in Neonates: Over 13 Years' Experience from a Single Centre. ( 27896158 )
2016
32
Two Cases of Intraluminal "Windsock" Diverticula Resulting in Partial Duodenal Obstruction. ( 27807587 )
2016
33
Duodenal obstruction due to annular pancreas associated with carcinoma of the duodenum. ( 27350844 )
2016
34
Neonatal Duodenal Obstruction: A 15-Year Experience. ( 27123397 )
2016
35
Preduodenal Portal Vein with Situs Inversus Totalis causing Duodenal Obstruction. ( 27398325 )
2016
36
Duodenal Obstruction Caused by an Annular Pancreas - Sonographic Diagnosis in a 4-Month-Old Dystrophic Infant. ( 27529456 )
2016
37
Laparoscopic simple oblique duodenoduodenostomy in management of congenital duodenal obstruction in children. ( 25536359 )
2015
38
Duodenal Obstruction Caused by Acute Appendicitis with Intestinal Malrotation in a Child. ( 26317163 )
2015
39
Comparison of the clinical impact of endoscopic ultrasound-guided choledochoduodenostomy and hepaticogastrostomy for bile duct obstruction with duodenal obstruction. ( 26418074 )
2015
40
Self-expandable metal stent placement for malignant duodenal obstruction distal to the bulb. ( 26426837 )
2015
41
CT of gastro-duodenal obstruction. ( 26280126 )
2015
42
EUS-guided choledochoduodenostomy with a lumen-apposing metal stent before duodenal stent placement for malignant biliary and duodenal obstruction. ( 25450606 )
2015
43
Successful endovascular treatment of duodenal obstruction caused by large abdominal aortic aneurysm. ( 26146235 )
2015
44
Upper ureteric transitional cell carcinoma, extending to the renal pelvis, presenting as duodenal obstruction. ( 26564110 )
2015
45
An unusual cause of duodenal obstruction in adults. ( 25910574 )
2015
46
The importance of antenatal diagnosis of congenital duodenal obstruction. ( 26216363 )
2015
47
Lumen-apposing metal stent placement for biliary drainage may be preferable in the setting of duodenal obstruction when dual stenting is performed. ( 25887726 )
2015
48
Video of the Month: EUS-Guided Choledochoduodenstomy With a Cautery-Equipped Lumen-Apposing Stent Allows Future Biliary Access in Patients With Type 2 Duodenal Obstruction. ( 26052765 )
2015
49
Bouveret's syndrome: An unusual cause of duodenal obstruction. ( 26239168 )
2015
50
Duodenal Obstruction as First Presentation of Metastatic Breast Cancer. ( 26266075 )
2015

Variations for Duodenal Obstruction

Expression for Duodenal Obstruction

Search GEO for disease gene expression data for Duodenal Obstruction.

Pathways for Duodenal Obstruction

GO Terms for Duodenal Obstruction

Biological processes related to Duodenal Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 8.96 CDON NODAL
2 lens development in camera-type eye GO:0002088 8.62 CDON NHS

Sources for Duodenal Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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