MCID: DDN009
MIFTS: 31

Duodenal Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenal Obstruction

MalaCards integrated aliases for Duodenal Obstruction:

Name: Duodenal Obstruction 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3558
ICD10 33 K31.5
MeSH 42 D004380
NCIt 47 C79548
SNOMED-CT 64 95532008
UMLS 69 C0013292

Summaries for Duodenal Obstruction

MalaCards based summary : Duodenal Obstruction is related to duodenitis and pancreatitis. An important gene associated with Duodenal Obstruction is HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta). The drugs Efavirenz and Maraviroc have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and breast.

Related Diseases for Duodenal Obstruction

Diseases related to Duodenal Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
id Related Disease Score Top Affiliating Genes
1 duodenitis 10.9
2 pancreatitis 10.3
3 aneurysm 10.2
4 aortic aneurysm 10.2
5 abdominal aortic aneurysm 10.1
6 situs inversus 10.0
7 pancreatic cancer 9.9
8 acute pancreatitis 9.8
9 gastroenteritis 9.8
10 superior mesenteric artery syndrome 9.8
11 eosinophilic gastroenteritis 9.8
12 peritonitis 9.8
13 retroperitoneal fibrosis 9.8
14 sporadic pheochromocytoma 9.8 CDON NODAL
15 celosomia 9.7 CDON NODAL
16 breast cancer 9.7
17 down syndrome 9.7
18 appendicitis 9.7
19 choledochal cyst 9.7
20 pelizaeus-merzbacher disease in female carriers 9.7 CDON NODAL
21 cerebral palsy 9.6
22 hepatitis 9.6
23 lymphoma 9.6
24 ileocolitis 9.6
25 omphalocele 9.6
26 blind loop syndrome 9.6
27 strongyloidiasis 9.6
28 sarcoma 9.6
29 obstructive jaundice 9.6
30 duodenal ulcer 9.6
31 adenocarcinoma 9.6
32 cerebritis 9.6
33 adenoma 9.6
34 intussusception 9.6
35 gastroduodenitis 9.6
36 fibromatosis 9.6
37 isolated levocardia 9.6
38 levocardia 9.6
39 laryngotracheoesophageal cleft type 2 9.6 CDON NODAL
40 hydrocephalus 9.6 CDON NODAL
41 laryngotracheoesophageal cleft type 4 9.5 CDON NODAL
42 schizophrenia 9.5
43 renal cell carcinoma 9.5
44 mayer-rokitansky-kuster-hauser syndrome 9.5
45 b-cell lymphomas 9.5
46 liver cirrhosis 9.5
47 paroxysmal nocturnal hemoglobinuria 9.5
48 ulcerative colitis 9.5
49 paraganglioma 9.5
50 villous adenoma 9.5

Graphical network of the top 20 diseases related to Duodenal Obstruction:



Diseases related to Duodenal Obstruction

Symptoms & Phenotypes for Duodenal Obstruction

Drugs & Therapeutics for Duodenal Obstruction

Drugs for Duodenal Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
2
Maraviroc Approved, Investigational Phase 4 376348-65-1 3002977
3 Anti-HIV Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Anti-Retroviral Agents Phase 4
6 Antiviral Agents Phase 4
7 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
8 Cytochrome P-450 CYP3A Inducers Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
10 HIV Integrase Inhibitors Phase 4
11 Integrase Inhibitors Phase 4
12 Nucleic Acid Synthesis Inhibitors Phase 4
13 Raltegravir Potassium Phase 4
14 Reverse Transcriptase Inhibitors Phase 4
15
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
16
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
17
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
18
Ticlopidine Approved Phase 3 55142-85-3 5472
19
Clopidogrel Approved, Nutraceutical Phase 3 120202-66-6, 113665-84-2 60606
20 Anesthetics Phase 2, Phase 3
21 Analgesics Phase 3
22 Analgesics, Non-Narcotic Phase 3
23 Antacids Phase 3
24 Anti-Inflammatory Agents Phase 3
25 Anti-Inflammatory Agents, Non-Steroidal Phase 3
26 Antipyretics Phase 3
27 Antirheumatic Agents Phase 3
28 Anti-Ulcer Agents Phase 3
29 Cyclooxygenase Inhibitors Phase 3
30 Fibrinolytic Agents Phase 3
31 Gastrointestinal Agents Phase 3
32 Neurotransmitter Agents Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Platelet Aggregation Inhibitors Phase 3
35
Proton pump inhibitors Phase 3
36 Purinergic P2 Receptor Antagonists Phase 3
37 Purinergic P2Y Receptor Antagonists Phase 3
38 Cola Nutraceutical Phase 1, Phase 2
39
Pancrelipase Approved 53608-75-6
40
Menthol Approved 2216-51-5 16666
41
Ethanol Approved 64-17-5 702
42
Epinephrine Approved, Vet_approved 51-43-4 5816
43
Indomethacin Approved, Investigational 53-86-1 3715
44 Racepinephrine Approved
45 pancreatin
46 Anti-Infective Agents, Local
47 Central Nervous System Depressants
48 Adrenergic Agents
49 Adrenergic Agonists
50 Adrenergic alpha-Agonists

Interventional clinical trials:

(show all 30)

id Name Status NCT ID Phase Drugs
1 A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy Completed NCT00870363 Phase 4 maraviroc in combination with 2 NRTIs (dual nucleoside reverse transcriptase inhibitor);maraviroc plus raltegravir in combination with 2 NRTIs (dual nucleoside reverse transcriptase inhibitor);efavirenz [or other NNRTI (non-nucleoside reverse transcriptase inhibitor)]
2 Covered Versus Uncovered Self-expandable Metallic Stents for Malignant Gastric Outlet Obstruction Completed NCT01646476 Phase 3
3 Effects of Delayed Enteral Nutrition on Inflammatory Responses and Immune Function Competence in Critically Ill Patients With Prolonged Fasting Completed NCT01834430 Phase 3
4 Study of Gastroduodenal Metallic Stent vs Gastrojejunostomy Recruiting NCT02784470 Phase 3
5 EUS - Guided Choledocho-duodenostomy Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Common Bile Duct Strictures Recruiting NCT03000855 Phase 2, Phase 3
6 Gastric Partitioning Procedure for the Treatment of Unresectable and Obstructive Distal Gastric Cancer Recruiting NCT02064803 Phase 3
7 Partially Covered Versus Uncovered Pyloro-duodenal Stents for Unresectable Malignant Gastric Outlet Obstruction. A Double Blinded Randomised Controlled Trial. Not yet recruiting NCT03223831 Phase 3
8 EUS - Guided Balloon-occluded Gastrojejunostomy Bypass Not yet recruiting NCT03223480 Phase 2, Phase 3
9 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
10 Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction Terminated NCT01424657 Phase 3
11 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
12 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD Withdrawn NCT01025739 Phase 2
13 Biliary Drainage in Patients With Duodenal Metal Stent Unknown status NCT02376907
14 EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms Completed NCT00991614
15 EUS-guided Biliary Drainage Versus Percutanenous Transhepatic Biliary Darinage for Malignant Biliary Obstruction After Failed ERCP Completed NCT02103413
16 Surgical Outcome and Differences on Histopathology in Patients With Alcoholic & Non Alcoholic Chronic Pancreatitis Completed NCT02048267
17 Esophageal High Resolution Manometry and Dysphagia Completed NCT01284894
18 Comparison of Duodenal Stenting vs Transpyloric and Duodenal Stenting for Malignant Obstruction Recruiting NCT03125148
19 Endoscopic Gastroenteric Anastomosis With New Tissue Apposing Stent in the Management of Antro-pyloroduodenal Obstruction : Evaluation of Feasibility, Efficacy and Tolerance. Recruiting NCT02562157
20 Efficacy of Partial Covered Double Bare Metal Stent Compared to Uncovered Double Bare Metal Stent in Malignant Biliary Obstruction Recruiting NCT02937246
21 Clinical Outcomes of the Endoscopic Resection of Premalignant and Malignant Gastrointestinal Lesions Recruiting NCT01750619
22 EUS BD vs ERCP TP for Pancreatic Cancer Recruiting NCT03063554
23 EUS-Guided Rendezvous or Direct Interventions Versus Advanced ERCP Techniques for Biliary Access and Therapy Recruiting NCT01678326
24 Magnamosis First-in-human Study of Feasibility and Safety Recruiting NCT02043392
25 Intraoperative Coeliac Plexus Alcohol Neurolysis Along With Frey's Procedure for a Better Pain Relief Active, not recruiting NCT02735330
26 Suspended Overlength Biliary Stents Preventing Duodenobiliary Reflux in Patients With Biliary Stricture Not yet recruiting NCT03310554
27 Endoscopic Access Loop With Bilio-enteric Anastomosis: A Prospective Randomized Comparison Between Gastric and Subcutaneous Accesses Not yet recruiting NCT03252379
28 Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction Terminated NCT00487552
29 Endoscopic Stenting Versus Surgical Bypass for Low Bile Duct Obstruction by Cancer of the Pancreatic Head Terminated NCT00753441
30 Effect of Papillary Epinephrine Spraying on Post-ERCP Pancreatitis in Patients Received Rectal Indomethacin Terminated NCT03057769 Papillary epinephrine spraying;Papillary saline spraying;Indomethacin

Search NIH Clinical Center for Duodenal Obstruction

Cochrane evidence based reviews: duodenal obstruction

Genetic Tests for Duodenal Obstruction

Anatomical Context for Duodenal Obstruction

MalaCards organs/tissues related to Duodenal Obstruction:

39
Pancreas, Colon, Breast, Kidney, T Cells, Lung, Liver

Publications for Duodenal Obstruction

Articles related to Duodenal Obstruction:

(show top 50) (show all 551)
id Title Authors Year
1
Giant Omphalocele Complicated by Postoperative Duodenal Obstruction. ( 28164002 )
2017
2
A case report of duodenal obstruction due to retroperitoneal bleeding after the rupture of a lower pancreaticoduodenal artery aneurysm. ( 28381781 )
2017
3
Annular pancreas causing duodenal obstruction in an adult. ( 28500113 )
2017
4
Severe muscle fasciculations and tremor in a cat with hypochloraemic metabolic alkalosis secondary to duodenal obstruction. ( 28491446 )
2017
5
A unique complication of self-expandable metal stent placement in malignant duodenal obstruction. ( 28928926 )
2017
6
Congenital Duodenal Obstruction, Situs Inversus Totalis, and Gastric Perforation in a Neonate. ( 28770132 )
2017
7
Endoscopic biliary stent insertion through specialized duodenal stent for combined malignant biliary and duodenal obstruction facilitated by stent or PTBD guidance. ( 28685637 )
2017
8
A Rare Cause of Duodenal Obstruction: Metastatic Parotid Mucoepidermoid Carcinoma. ( 28351791 )
2017
9
Distal Duodenal Obstruction: a Surgical Enigma. ( 28659679 )
2017
10
Laparoscopic versus open surgery in management of congenital duodenal obstruction in neonates: a single-center experience with 112 cases. ( 28943138 )
2017
11
Roux-en-Y duodenojejunostomy for surgical management of isolated duodenal obstruction due to chronic pancreatitis. ( 28189119 )
2017
12
Temporary duodenal stenting as a bridge to ERCP for inaccessible papilla due to duodenal obstruction: a retrospective study. ( 27652301 )
2016
13
Endoscopic choledochoduodenostomy and gastrojejunostomy in the treatment of biliary and duodenal obstruction. ( 26684602 )
2016
14
The role of palliative surgery in the management of advanced pancreatic cancer in patients with biliary and duodenal obstruction. ( 26868166 )
2016
15
Palliation double stenting for malignant biliary and duodenal obstruction. ( 26889267 )
2016
16
Randomized controlled exploratory study comparing the usefulness of two types of metallic stents with different axial forces for the management of duodenal obstruction caused by pancreatobiliary cancer. ( 26946214 )
2016
17
Neonatal Duodenal Obstruction: A 15-Year Experience. ( 27123397 )
2016
18
Congenital duodenal obstruction with delayed presentation: seven years of experience. ( 27695493 )
2016
19
Duodenal obstruction due to annular pancreas associated with carcinoma of the duodenum. ( 27350844 )
2016
20
Is laparoscopic surgery better than open surgery for the repair of congenital duodenal obstruction? A review of the current evidences. ( 27622585 )
2016
21
Laparoscopic repair of congenital duodenal obstruction is feasible even in small-volume centres. ( 27652789 )
2016
22
Intestinal malrotation associated with duodenal obstruction secondary to Ladd's bands. ( 27777485 )
2016
23
Duodenal Obstruction Caused by an Annular Pancreas - Sonographic Diagnosis in a 4-Month-Old Dystrophic Infant. ( 27529456 )
2016
24
Preduodenal Portal Vein with Situs Inversus Totalis causing Duodenal Obstruction. ( 27398325 )
2016
25
Congenital Duodenal Obstruction in Neonates: Over 13 Years' Experience from a Single Centre. ( 27896158 )
2016
26
Two Cases of Intraluminal "Windsock" Diverticula Resulting in Partial Duodenal Obstruction. ( 27807587 )
2016
27
Single-session double-stent placement in concomitant malignant biliary and duodenal obstruction with a cautery-tipped lumen apposing metal stent. ( 27706541 )
2016
28
Preduodenal Portal Vein Associated with Duodenal Obstruction of other Etiology: A Case Series. ( 27896162 )
2016
29
Duodenal Obstruction on 99mTc-DISIDA Cholescintigraphy: A Noninvasive Approach to Bowel Obstruction Diagnosis. ( 27834726 )
2016
30
Congenital duodenal obstruction: causes and imaging approach. ( 27324508 )
2016
31
An Unusual Cause of Duodenal Obstruction: Persimmon Phytobezoar. ( 28100951 )
2016
32
Association Between Prenatal Sonographic Findings of Duodenal Obstruction and Adverse Outcomes. ( 27466262 )
2016
33
An unusual cause of duodenal obstruction in adults. ( 25910574 )
2015
34
Comparison between uncovered and covered self-expandable metal stent placement in malignant duodenal obstruction. ( 25663777 )
2015
35
The importance of antenatal diagnosis of congenital duodenal obstruction. ( 26216363 )
2015
36
Video of the Month: EUS-Guided Choledochoduodenstomy With a Cautery-Equipped Lumen-Apposing Stent Allows Future Biliary Access in Patients With Type 2 Duodenal Obstruction. ( 26052765 )
2015
37
Comparison of the clinical impact of endoscopic ultrasound-guided choledochoduodenostomy and hepaticogastrostomy for bile duct obstruction with duodenal obstruction. ( 26418074 )
2015
38
EUS-guided choledochoduodenostomy with a lumen-apposing metal stent before duodenal stent placement for malignant biliary and duodenal obstruction. ( 25450606 )
2015
39
Lumen-apposing metal stent placement for biliary drainage may be preferable in the setting of duodenal obstruction when dual stenting is performed. ( 25887726 )
2015
40
Self-expandable metal stent placement for malignant duodenal obstruction distal to the bulb. ( 26426837 )
2015
41
Laparoscopic simple oblique duodenoduodenostomy in management of congenital duodenal obstruction in children. ( 25536359 )
2015
42
Successful endovascular treatment of duodenal obstruction caused by large abdominal aortic aneurysm. ( 26146235 )
2015
43
Comparison of the clinical impact of endoscopic ultrasound-guided choledochoduodenostomy and hepaticogastrostomy for bile duct obstruction with duodenal obstruction. ( 26382307 )
2015
44
Duodenal Obstruction as First Presentation of Metastatic Breast Cancer. ( 26266075 )
2015
45
Upper ureteric transitional cell carcinoma, extending to the renal pelvis, presenting as duodenal obstruction. ( 26564110 )
2015
46
A Case of Duodenal Obstruction and Pancreatitis Due to Intragastric Balloon. ( 26185725 )
2015
47
CT of gastro-duodenal obstruction. ( 26280126 )
2015
48
Bouveret's syndrome: An unusual cause of duodenal obstruction. ( 26239168 )
2015
49
Duodenal Obstruction Caused by Acute Appendicitis with Intestinal Malrotation in a Child. ( 26317163 )
2015
50
Single-session EUS-guided FNA and biliary drainage with use of a biflanged lumen apposing stent on an electrocautery enhanced delivery system: one-stop shop for unresectable pancreatic mass with duodenal obstruction. ( 25922247 )
2015

Variations for Duodenal Obstruction

Expression for Duodenal Obstruction

Search GEO for disease gene expression data for Duodenal Obstruction.

Pathways for Duodenal Obstruction

GO Terms for Duodenal Obstruction

Biological processes related to Duodenal Obstruction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 8.96 CDON NODAL
2 lens development in camera-type eye GO:0002088 8.62 CDON NHS

Sources for Duodenal Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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