MCID: DDN001
MIFTS: 60

Duodenal Ulcer malady

Gastrointestinal diseases, Rare diseases categories
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Summaries for Duodenal Ulcer

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65Wikipedia, 33MalaCards
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Wikipedia:65 A peptic ulcer is a distinct breach in the mucosal lining of the stomach (gastric ulcer) or the first... more...

MalaCards: Duodenal Ulcer, also known as stress ulcer, is related to gastritis and pancreatitis. An important gene associated with Duodenal Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Defensins and Peptide ligand-binding receptors. The drugs prazepam and maprotiline and the compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Duodenal Ulcer

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

duodenal ulcer 8 10 45 62
stress ulcer 8 45 62
curling ulcer 8 62
du - acute + perforation 8
duodenal ulcer disease 45
curling's ulcers 8
stress ulcer nos 8


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Disease Ontology8 DOID:1724
MeSH35 D004381
SNOMED-CT58 39755000
ICD1025 K26

Related Diseases for Duodenal Ulcer

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17GeneCards, 18GeneDecks
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Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.2IL1RN, SCT, DEFB4A
2pancreatitis31.0CCK, SST, SCT
3dyspepsia30.9HRH2, CCK
4zollinger-ellison syndrome30.7SCT, SST, HRH2
5duodenogastric reflux30.6CCK
6atrophic gastritis30.6SCT, SST, IL1RN
7pancreatic cancer30.6CCK, SST, SCT
8gastrinoma30.3SCT, SST
9gastroesophageal reflux disease30.3HRH2, CCK, SCT
10dumping syndrome30.2SST
11pneumonia30.2HRH2, DEFB1, DEFB4A
12alcoholic pancreatitis30.1CCK, SCT
13pancreas disease30.1CCK, SCT
14stomach cancer30.1HDC, MUC6, CCK, IL1RN, HRH2
15wermer syndrome30.1SST, SCT
16steatorrhea30.1SCT, SST, CCK
17nephritis30.0LTA, IL1RN
18diabetes mellitus30.0CCK, SST, SCT
19acute pancreatitis30.0SCT, SST, CCK, IL1RN, HRH2
20adenocarcinoma30.0SCT, MUC6, SST, CCK
21neuroendocrine tumor30.0CCK, SST, SCT, HDC
22sarcoidosis30.0LTA, IL1RN, DEFB1, DEFB4A
23cystic fibrosis29.9DEFB4A, DEFB1, SCT, MUC6
24peptic ulcer disease29.9HDC, SCT, SST, CCK, HRH2
25duodenitis11.5
26esophagitis10.6
27gastroduodenitis10.6
28h. pylori infection10.6
29gastric ulcer10.5
30blindness10.5
31neuhauser daly magnelli syndrome10.5
32gastric outlet obstruction10.4
33hepatitis10.3
34hiatus hernia10.3
35gastrojejunal ulcer10.3
36meckel's diverticulum10.3
37arteriovenous malformation10.3
38bile reflux10.3
39peptic esophagitis10.3
40pneumothorax10.3
41purpura10.3
42duodenal ulcer due to antral g-cell hyperfunction10.3
43eosinophilic gastroenteritis10.2
44ovarian hyperstimulation syndrome10.2
45situs inversus10.2
46gastric dilatation10.2
47insulinoma10.2
48pneumatosis cystoides intestinalis10.2
49duodenal obstruction10.2
50gastroenteritis10.2

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to duodenal ulcer

Symptoms for Duodenal Ulcer

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Drugs & Therapeutics for Duodenal Ulcer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Duodenal Ulcer

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Anatomical Context for Duodenal Ulcer

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33MalaCards
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MalaCards organs/tissues related to Duodenal Ulcer:

33
Small intestine, Liver, Colon, Testes, Pancreas, Heart, Endothelial, T cells, Kidney, Monocytes

Animal Models for Duodenal Ulcer or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Duodenal Ulcer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8LTA, HRH2, CCK, SST, SCT, HDC
2MP:00053767.1LTA, HDC, SCT, SST, CCK, IL1RN

Publications for Duodenal Ulcer

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Sources:
52PubMed
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Articles related to Duodenal Ulcer:

(show top 50)    (show all 727)
idTitleAuthorsYear
1
Acute mesenteric ischemia and duodenal ulcer perforation: a unique double pathology. (23110681)
2012
2
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
3
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. (21220246)
2011
4
Antiulcer activity of Andrographis paniculata (Burm.f.) wall. against cysteamine-induced duodenal ulcer in rats. (21800503)
2011
5
One-stage laparoscopic-assisted resection of gastrojejunocolic fistula after gastrojejunostomy for duodenal ulcer: a case report. (22054096)
2011
6
Pyloric Pseudodiverticulum: A rare incidental finding during the repair of perforated duodenal ulcer. (23133235)
2010
7
Recurrent duodenal ulcer due to nonsteroidal anti-inflammatories following the suspension of antiulcer medication. (19938884)
2009
8
Duodenal ulcer due to yttrium microspheres used for selective internal radiation therapy of hepatocellular cancer. (18950763)
2009
9
Interleukin-1beta gene polymorphism as a predictor of eradication treatment efficacy in gastric and duodenal ulcer associated with Helicobacter pylori]. (19145908)
2008
10
Pattern of change in the frequency of Helicobacter pylori with perforated duodenal ulcer. (19999201)
2008
11
Changes in reducing power profile of gastric juice in patients with active duodenal ulcer. (16095868)
2005
12
Deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer: a correlated study. (15793868)
2005
13
Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries. (15866209)
2005
14
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
15
Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: study by 24-h pH monitoring in patients with gastric or duodenal ulcer. (15870971)
2005
16
Surgical management of perforated duodenal ulcer: the changing scene. (15816264)
2004
17
Multimedia article: management of duodenal ulcer perforation with combined laparoscopic and endoscopic methods. (15803242)
2004
18
Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infected duodenal ulcer patients. (12522049)
2003
19
Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy. (14512101)
2003
20
Effect of Helicobacter pylori eradicated therapy on water gastric emptying in patients with active duodenal ulcer. (14535981)
2003
21
Association between Helicobacter pylori virulence and duodenal ulcer disease in patients from Hong Kong in China]. (12697114)
2003
22
Simple closure of chronic duodenal ulcer perforation in the era of Helicobacter pylori: an old procedure, today's solution. (14571746)
2003
23
The sixth decision regarding perforated duodenal ulcer. (12500837)
2002
24
Relationship between the birth cohort pattern of Helicobacter pylori infection and the epidemiology of duodenal ulcer. (12145391)
2002
25
Detection of Helicobacter pylori-associated asymptomatic duodenal ulcer in a boy. (11982907)
2002
26
Eradication of Helicobacter pylori in duodenal ulcer disease tetracycline & furazolidone vs. metronidazole & amoxicillin in omeprazole based triple therapy. (11889461)
2002
27
14C urea breath test does not predict density of Helicobacter pylori in duodenal ulcer disease. (11558321)
2001
28
Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer? (11421880)
2001
29
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. (11507979)
2001
30
Helicobacter pylori infection in patients with perforated chronic duodenal ulcer. (11676339)
2001
31
Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. (10930902)
2000
32
Ultrastructural study of the gastric mucosa and Helicobacter pylori in duodenal ulcer patients. (11500709)
2000
33
Five-day triple therapy in Helicobacter pylori-positive duodenal ulcer: an eighteen-month follow-up. (10993428)
2000
34
Smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients in Taiwan. (10548360)
1999
35
HLA-DQA1 genes involved in the genetic susceptibility to duodenal ulcer in Wuhan Hans]. (10194252)
1999
36
Effect of chronic duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF receptor expression in humans. (9881512)
1998
37
Effect of curing Helicobacter pylori infection on intragastric acidity during treatment with ranitidine in patients with duodenal ulcer. (9274468)
1997
38
Presence of the cagA gene in the majority of Helicobacter pylori strains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis. (9398887)
1996
39
Helicobacter pylori and duodenal ulcer: evidence for a histamine pathways-involving link. (8931414)
1996
40
Immunogenetic analysis of the human leukocyte antigen DQA1 locus in patients with duodenal ulcer or chronic atrophic gastritis harbouring Helicobacter pylori. (8574742)
1995
41
Prospective randomized study comparing three surgical techniques for the treatment of gastric outlet obstruction secondary to duodenal ulcer. (8101050)
1993
42
pH-dependent secretion of gastrin in duodenal ulcer disease: effect of suppressing Helicobacter pylori. (1459351)
1992
43
Patients with duodenitis have gastric secretory and motor functions like those of duodenal ulcer patients: results of a short-term treatment with ranitidine. (2066545)
1991
44
Ceruloplasmin activity in blood serum in stomach and duodenal ulcers]. (1966196)
1990
45
Long-term treatment for gastric and duodenal ulcer. (1983413)
1990
46
Oxyntic mucosa histology in omeprazole-treated patients suffering from duodenal ulcer or Zollinger-Ellison syndrome. (3792669)
1986
47
Use of a provocation test for objective assessment of dumping syndrome in patients undergoing surgery for duodenal ulcer. (7468560)
1980
48
Bleeding duodenal ulcer as a complication of treatment of status asthmaticus with adrenal corticosteroids. (6967706)
1980
49
Gastritis, duodenitis, and bleeding duodenal ulcer following mefenamic acid therapy. (949194)
1976
50
A five-to ten-year follow-up study of the Billroth I and Billroth II (polya) operations for duodenal, gastric and gastrojejunal ulcer and gastroenterostomy with vagotomy in the treatment of duodenal ulcer. (13480410)
1957

Variations for Duodenal Ulcer

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Expression for genes affiliated with Duodenal Ulcer

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Duodenal Ulcer

Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for genes affiliated with Duodenal Ulcer

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Duodenal Ulcer

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45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Duodenal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1epft4510.2CCK, SCT
2l-bpa4510.1SCT, CCK
3caerulein4510.1SCT, CCK
4pancreozymin4510.1SCT, CCK
5cerulein4510.0CCK, SCT
6minigastrin4510.0CCK, SST
7enprostil45 2911.0HRH2, SST
8vapreotide45 29 1111.9SST, CCK
9pepsinogen459.9SCT, CCK, HRH2
10ranitidine45 29 24 1112.9CCK, SCT, HRH2
11lafutidine459.9SST, SCT, HRH2
12alosetron45 1110.9SST, CCK
13tetrodotoxin45 61 2911.8HRH2, SCT, CCK
14taurodeoxycholate459.8SCT, CCK, SST
15bicarbonate459.8HRH2, CCK, SCT
16loxiglumide459.8CCK, SCT, SST
17pirenzepine45 29 1111.8HRH2, SST, CCK
18benzodiazepines459.8CCK, HRH2
19oxyntomodulin45 6110.8CCK, SST, SCT
20octreotide45 61 29 1112.7SST, SCT, CCK
21c-peptide459.7CCK, SCT, SST
22triprolidine45 29 1111.7HDC, HRH2
23glipizide45 51 1111.7SST, HRH2
24atropine45 29 1111.5HRH2, SCT, SST, CCK
25epinephrine45 24 1111.5SCT, SST, HRH2, IL1RN
26lipoteichoic acid459.4IL1RN, LTA, DEFB4A
27acth459.4IL1RN, SCT, SST, CCK
28bethanechol45 29 1111.4SST, CCK
29norepinephrine45 24 1111.4CCK, IL1RN, SST, SCT
30forskolin45 51 1111.3HRH2, LTA, SCT, CCK
31amine459.3SCT, HRH2, HDC
32cyclosporin a45 29 6111.2SCT, IL1RN, LTA, CCK
33endotoxin459.2HRH2, IL1RN, DEFB4A, LTA
34adenylate459.1HRH2, IL1RN, CCK, SST, SCT
35acetylcholine45 51 29 24 1113.0SCT, SST, CCK, LTA, HRH2
36lactate459.0HRH2, IL1RN, LTA, SST
37gaba458.9HDC, CCK, SCT, SST
38cholesterol45 29 24 1111.9LTA, CCK, HRH2, IL1RN, MUC6
39hydrogen45 249.8HDC, SCT, HRH2, IL1RN
40omeprazole45 51 29 24 1112.7HRH2, SST, SCT, HDC, CCK
41dopamine45 29 24 1111.6SCT, HDC, SST, CCK
42glucose458.5DEFB1, SCT, SST, LTA, CCK
43dexamethasone45 51 29 1111.2LTA, IL1RN, DEFB1, CCK, SST, DEFB4A
44glutamate458.2IL1RN, SST, SCT, HDC, LTA, CCK
45pge2457.9SST, SCT, CCK, HDC, HRH2, LTA
46tyrosine457.9CCK, IL1RN, HDC, DEFB4A, LTA, SCT
47rantes457.8SCT, HDC, LTA, DEFB1, DEFB4A, IL1RN
48histamine45 29 249.7SCT, SST, CCK, IL1RN, HRH2, DEFB4A
49calcium45 51 24 1110.1CCK, MUC6, HDC, HRH2, LTA, IL1RN
50retinoic acid45 247.8DEFB1, HDC, DEFB4A, SCT, SST, CCK

GO Terms for genes affiliated with Duodenal Ulcer

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16Gene Ontology
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Cellular components related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9CCK, SST, IL1RN, LTA
2Golgi lumenGO:0057968.5DEFB1, MUC6, DEFB4A
3extracellular regionGO:0055767.6CCK, SST, MUC6, SCT, DEFB1, DEFB4A

Biological processes related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual learningGO:0085429.8HRH2, SCT
2response to nutrientGO:0075849.6LTA, SST
3memoryGO:0076139.5HRH2, IL1RN
4response to drugGO:0424939.3IL1RN, LTA, SST
5G-protein coupled receptor signaling pathwayGO:0071868.9DEFB4A, DEFB1, SST
6immune responseGO:0069558.8HRH2, IL1RN, DEFB1, DEFB4A

Molecular functions related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4CCK, SST, SCT

Products for genes affiliated with Duodenal Ulcer

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Sources for Duodenal Ulcer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet