MCID: DDN001
MIFTS: 63

Duodenal Ulcer malady

Gastrointestinal category

Summaries for Duodenal Ulcer

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

MalaCards: Duodenal Ulcer, also known as stress ulcer, is related to gastric ulcer and duodenitis. An important gene associated with Duodenal Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Immune response Bacterial infections in normal airways and G alpha (q) signalling events. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and colon, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Duodenal Ulcer

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

duodenal ulcer 8 10 45 61
stress ulcer 8 45 61
curling ulcer 8 61
acute duodenal ulcer with hemorrhage, with perforation and with obstruction 8
acute duodenal ulcer with hemorrhage and perforation, with obstruction 8
acute duodenal ulcer with perforation, without mention of obstruction 8
chronic duodenal ulcer without hemorrhage and without perforation 8
acute duodenal ulcer with perforation but without obstruction 8
acute duodenal ulcer with perforation, with obstruction 8
acute duodenal ulcer with hemorrhage, with obstruction 8
acute duodenal ulcer with perforation and obstruction 8
acute duodenal ulcer with hemorrhage and perforation 8
acute duodenal ulcer with hemorrhage and obstruction 8
acute duodenal ulcer with perforation 8
acute duodenal ulcer with hemorrhage 8
du - acute + perforation 8
duodenal ulcer disease 45
curling's ulcers 8
stress ulcer nos 8


External Ids:

Disease Ontology8 DOID:1724
MeSH35 D004381
SNOMED-CT57 39755000

Related Diseases for Duodenal Ulcer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Duodenal Ulcer family:

duodenal ulcer due to antral g-cell hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1gastric ulcer31.6GSR, HRH2, CYP2C19, TFF1, GAST, S100A8
2duodenitis31.1S100A8, GAST
3dyspepsia30.8CCK, GAST, HRH2
4zollinger-ellison syndrome30.6GRP, SST, HRH2, SCT, GAST
5atrophic gastritis30.5S100A8, GAST, TFF1, SST, IL1RN, SCT
6duodenogastric reflux30.4GAST, CCK
7bile reflux30.3TFF1, CCK
8stomach cancer30.2GAST
9gastrinoma30.2SST, SCT, GAST, GRP
10pancreatitis, chronic30.2SST, CCK, SCT, TFF1, GRP, MUC6
11gastroesophageal reflux disease30.2CYP2C19, HRH2, GAST, SCT, CCKAR, CCK
12insulinoma30.2GSR, GAST, GRP, SST, SCT
13gastroduodenitis30.0GAST
14nephritis30.0LTA, IL1RN
15cushing's syndrome30.0SST
16hypoglycemia30.0SCT, SST, GAST
17multiple endocrine neoplasia30.0GAST
18steatorrhea30.0SCT, CCK, SST
19wermer syndrome30.0GAST, SST, SCT
20cystic fibrosis30.0IL8, MUC6, DEFB4A, DEFB1, SCT, S100A8
21atherosclerosis30.0IL1RN, IL8, CXCL1
22acute pancreatitis30.0HRH2, CCKAR, CCK, IL8, IL1RN, SST
23adenoma30.0MUC6, SST, TFF1, GAST, SCT, S100A8
24adenocarcinoma30.0GRP, SST, TFF1, CCK, SCT, S100A8
25dumping syndrome30.0SST
26asthma30.0TGIF1, GSR, HRH2, S100A8, SCT, HDC
27alcoholic pancreatitis30.0CCK, SCT
28h. pylori infection10.9
29gastric outlet obstruction10.4
30tremors, nystagmus and duodenal ulcers10.4
31neuhauser daly magnelli syndrome10.3
32gastric dilatation10.2
33arteriovenous malformation10.2
34peptic esophagitis10.2
35gastrojejunal ulcer10.2
36n syndrome10.2
37duodenal ulcer due to antral g-cell hyperfunction10.2
38meckel's diverticulum10.2
39duodenal gastrinoma10.2
40eosinophilic gastroenteritis10.2
41ovarian hyperstimulation syndrome10.2
42situs inversus10.2
43pneumatosis cystoides intestinalis10.2
44annular pancreas10.2
45burns10.0
46megaesophagus10.0
47limited scleroderma10.0
48anisakiasis10.0
49acth-secreting pituitary adenoma10.0
50williams-beuren syndrome10.0

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to duodenal ulcer

Clinical Features for Duodenal Ulcer

Drugs & Therapeutics for Duodenal Ulcer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Duodenal Ulcer

Anatomical Context for Duodenal Ulcer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Duodenal Ulcer:

33
Heart, Small intestine, Colon, Kidney, Liver, Pancreas, Salivary gland, Adrenal gland, Monocytes, T cells, B cells, Endothelial, Fetal liver, Pancreatic islet

Animal Models for Duodenal Ulcer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Duodenal Ulcer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2TGIF1, CCK, SCT, GAST, TFF1, HDC

Publications for Duodenal Ulcer

Sources:
51PubMed
See all sources

Articles related to Duodenal Ulcer:

(show top 50)    (show all 784)
idTitleAuthorsYear
1
Refractory bleeding from a malignant duodenal ulcer treated with placement of a fully-covered gastroduodenal stent. (23645380)
2013
2
Perforated duodenal ulcer; management in a resource poor, semi-urban nigerian hospital. (24027411)
2013
3
Therapeutic management of perforated gastro-duodenal ulcer: literature review. (24011662)
2013
4
Management of the difficult duodenal stump in penetrating duodenal ulcer disease: a comparative analysis of duodenojejunostomy with "classical" stump closure (Nissen-Bsteh). (22903877)
2012
5
Extravascular submucosal coil migration after transcatheter arterial embolization for a massively bleeding duodenal ulcer. (21290124)
2011
6
Laparoscopic repair of perforated peptic duodenal ulcer. (20402333)
2010
7
Associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease in Chinese Han population. (19804405)
2010
8
Pneumomediastinum, pneumothorax, and subcutaneous emphysema due to duodenal ulcer. (20563372)
2010
9
Perforated duodenal ulcer in a young child: an uncommon condition. (20387362)
2009
10
Influence of three point mutations in TNF-alpha promoter gene in clinical manifestations and complications of stomach and duodenal ulcer]. (19548417)
2009
11
The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study. (19338650)
2009
12
The Helicobacter pylori duodenal ulcer promoting gene, dupA in China. (18950522)
2008
13
Association of specific haplotype of TNFalpha with Helicobacter pylori-mediated duodenal ulcer in eastern Indian population. (19147919)
2008
14
Diffuse luminal ulceration resulting from duodenal plasmacytoma. (17173910)
2007
15
Intrauterine hemorrhage from an umbilical cord ulcer associated with fetal duodenal atresia: a case report. (16900345)
2007
16
MUC 1 mucin content in gastric juice of duodenal ulcer patients: effect of Helicobacter pylori eradication therapy. (17609879)
2007
17
Sudden fetal death associated with both duodenal atresia and umbilical cord ulcer: a case report and review. (16586238)
2006
18
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
19
Helicobacter pylori infection rates in duodenal ulcer patients in a population with high prevalence of infection. (16041118)
2005
20
Multimedia article: management of duodenal ulcer perforation with combined laparoscopic and endoscopic methods. (15803242)
2004
21
Islet cell tumor arising from a heterotopic pancreas in the duodenal wall with ulceration. (14738869)
2004
22
IgG subclass responses in childhood Helicobacter pylori duodenal ulcer: evidence of T-helper cell type 2 responses. (15270742)
2004
23
Helicobacter pylori clearance and eradication with triple therapy in duodenal ulcer patients. 1995. (15485199)
2004
24
Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infected duodenal ulcer patients. (12522049)
2003
25
History in our lifetime: the changing nature of refractory duodenal ulcer in the era of histamine H2 receptor antagonists. (14567455)
2003
26
Helicobacter pylori infection induces duodenitis and superficial duodenal ulcer in Mongolian gerbils. (12740333)
2003
27
The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication--an electrogastrographic study. (12120894)
2002
28
Synchronous perforation of a Meckel's diverticulum and duodenal ulcer. (12463714)
2002
29
Diet and duodenal ulcer. (11057920)
2000
30
Eradication of Helicobacter pylori compared with long-term acid suppression in duodenal ulcer disease. A randomized trial with 2-year follow-up. The Danish Ulcer Study Group. (11099054)
2000
31
Hypersecretory duodenal ulcer and Helicobacter pylori infection: a four-year follow-up study. (10975785)
2000
32
Antibody response to specific H. pylori antigens in functional dyspepsia, duodenal ulcer disease, and health. (9707041)
1998
33
Pathogenetic factors affecting gastroesophageal reflux in patients with esophagitis and concomitant duodenal ulcer: a multivariate analysis. (11819262)
1998
34
Epidermal growth factor and transforming growth factor alpha in duodenal ulcer and non-ulcer dyspepsia patients before and after Helicobacter pylori eradication. (9517524)
1998
35
Comparison of dual and triple therapy for the eradication of Helicobacter pylori in duodenal ulcer patients. (17338021)
1997
36
Effects of smoking and Helicobacter pylori on prostaglandin concentrations in gastric and duodenal mucosa of patients with duodenal ulcer and duodenitis. (9439067)
1997
37
Gastric outlet obstruction caused by prepyloric mucosal diaphragm mimicking duodenal ulcer: a case report. (9116415)
1997
38
The hormonal characteristics of the pathogenesis of gastric peptic ulcer and duodenal peptic ulcer]. (8779096)
1995
39
Endogenous CCK in the control of gastric secretory response to meal in normal subjects and duodenal ulcer patients. (8185212)
1994
40
Patients with duodenitis have gastric secretory and motor functions like those of duodenal ulcer patients: results of a short-term treatment with ranitidine. (2066545)
1991
41
Long-term treatment for gastric and duodenal ulcer. (1983413)
1990
42
Is antral gastrin important in the resistance of duodenal ulcers to H2 receptor antagonists or in recurrent ulceration after highly selective vagotomy? (1973394)
1990
43
Effect of alkalies on gastric acidity in patients with duodenal ulcer]. (2075140)
1990
44
Duodenogastric reflux in healed duodenal ulcer. (2371997)
1990
45
Psychological distress in duodenal ulcer and acute gastroduodenitis. A controlled study. (7172957)
1982
46
Duodenal ulcer stenosis with gastric dilatation. Treatment by vagotomy and pyloroplasty. (5546330)
1971
47
Chronic relapsing pancreatitis apparently initiated by trauma: report of a case with eventual development of pancreatic calcification, diabetes mellitus, pancreatic steatorrhea, and duodenal ulcer with hematemesis and melena. (13826234)
1959
48
Subtotal gastrectomy with and without vagotomy for duodenal and gastrojejunal ulcer; present status. (13376325)
1956
49
Studies on pepsin secretion. I. nocturnal and hypoglycemic secretion in patients with duodenal ulcer and without gastro-intestinal disease. (14849716)
1951
50
RESULTS OF PARTIAL GASTRECTOMY FOR BLEEDING DUODENAL, GASTRIC, AND GASTROJEJUNAL ULCER. (17857890)
1941

Genetic Variations for Duodenal Ulcer

Expression for genes affiliated with Duodenal Ulcer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Duodenal Ulcer

Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for genes affiliated with Duodenal Ulcer

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG
See all sources

Pathways related to Duodenal Ulcer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
Hide members
10.4IL8, DEFB4A, IL1RN
2
Hide members
10.3GRP, GAST, CCK, CCKAR
3
Hide members
10.3HRH2, SST, CXCL1, IL8, SCT, GRP
4
Hide members
10.2SST, HRH2, IL8, CCKAR, CCK, SCT

Compounds for genes affiliated with Duodenal Ulcer

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Duodenal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1pge24510.9GRP, SST
2estrogen4510.9DEFB4A
3glutamate4510.8HDC, SCT, CCK, GAST
4pepsinogen4510.8CCK, GRP, SCT, GAST, HRH2
5indomethacin45 60 29 1113.8GRP, SCT, TFF1, CCKAR
6lafutidine4510.8HRH2, GAST, SST, SCT
7amoxicillin45 50 1112.8S100A8, HRH2, GAST, CYP2C19, IL1RN
8pirenzepine45 29 1112.8GAST, CCK, HRH2, SST, GRP
9ranitidine45 29 11 2413.8HRH2, CCK, CYP2C19, SCT
10loxiglumide4510.8SST, GRP, GAST, SCT, CCK, CCKAR
11clarithromycin45 1111.7IL1RN, GAST, S100A8, HRH2, IL8, CYP2C19
12rantes4510.7S100A8, SCT, HDC, DEFB4A, LTA, CXCL1
13oxyntomodulin45 6011.7CCK, GAST, GRP, SCT, SST
14minigastrin4510.7GAST, SST, GRP, CCK
15caerulein4510.7CCK, CCKAR, SCT, GRP
16atropine45 29 1112.7GAST, SCT, GRP, CCKAR, HRH2, SST
17endotoxin4510.7S100A8, CXCL1, DEFB4A, HRH2
18cycloheximide4510.7TFF1, LTA
19bethanechol45 29 1112.7SST, GRP, GAST, CCK
20pantoprazole45 50 11 2413.7HRH2, GAST, CYP2C19, SST
21octreotide45 60 29 1113.7CCKAR, SST, GRP, GAST, SCT, CCK
22omeprazole45 29 50 11 2414.7CCKAR, CCK, S100A8, SCT, GAST, HDC
23epinephrine45 11 2412.7IL1RN, SCT, HRH2, GRP, SST, CXCL1
24gaba4510.7SCT, HDC, CCK, GRP, GAST, CCKAR
25lansoprazole50 45 11 2413.7IL1RN, CYP2C19, GAST, HRH2
26dopamine45 29 11 2413.6HDC, GRP, GAST, CYP2C19, TGIF1, CCK
27dexamethasone45 50 29 1113.6DEFB1, DEFB4A, GRP, LTA, CYP2C19, CXCL1
28cyclic amp45 2411.6HDC, GRP, HRH2, CCKAR, TGIF1, SCT
29acetylcholine45 50 29 11 2414.6SST, CCK, SCT, GAST, GRP, LTA
30tetrodotoxin45 60 2912.6HRH2, SCT, CCKAR, CCK, GRP
31lactate4510.6TGIF1, HRH2, IL8, LTA, GSR, IL1RN
32histamine45 29 2412.6SCT, GAST, HRH2, CCK, S100A8, HDC
33adenylate4510.6SST, GAST, CCK, SCT, CXCL1, GSR
34testosterone45 60 11 2413.6IL1RN, GAST, SCT, CCK, TGIF1, SST
35propranolol45 29 50 11 2414.6GAST, SST, SCT, GRP, CYP2C19
36dtpa4510.6CCK, GRP, SST, GAST
37lorglumide45 2911.6GAST, CCK, CCKAR
38vegf4510.5TGIF1, CXCL1, LTA, SST, GRP, TFF1
39l3652604510.5CCK, CCKAR, GAST
40retinoic acid45 2411.5TFF1, HDC, DEFB1, DEFB4A, GRP, SST
41acth4510.5SCT, GRP, SST, IL1RN, CCK, GAST
42ym0224510.5GAST, CCK, CCKAR
43progesterone45 60 29 11 2414.5IL1RN, TGIF1, CXCL1, CYP2C19, MUC6, LTA
44tyrosine4510.5S100A8, CCK, LTA, SCT, HDC, CYP2C19
45calcium45 50 11 2413.5CCKAR, CCK, S100A8, SCT, GAST, MUC6
46devazepide45 29 6012.4CCK, CCKAR, GAST
47genistein45 29 60 2 11 2415.3IL8, SST, TGIF1, GRP, TFF1, GSR
48cholesterol45 29 11 2413.3HRH2, CCKAR, IL1RN, MUC6, LTA, TGIF1
49cyclosporin a45 29 6012.2CCK, LTA, SCT, IL8, IL1RN, CXCL1
50taurodeoxycholate4510.1SCT, SST, CCK

GO Terms for genes affiliated with Duodenal Ulcer

Sources:
16Gene Ontology
See all sources

Cellular components related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.4MUC6, DEFB4A, DEFB1
2extracellular regionGO:00557610.1IL8, CCK, S100A8, SCT, GAST, DEFB1
3extracellular spaceGO:0056159.9CCK, S100A8, TFF1, GRP, SST, LTA

Biological processes related to Duodenal Ulcer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.5CCKAR, TFF1, SST
2G-protein coupled receptor signaling pathwayGO:00718610.5DEFB1, GAST, DEFB4A, SST, CXCL1, IL8
3immune responseGO:00695510.5DEFB4A, DEFB1, HRH2, IL8, IL1RN, CXCL1
4maintenance of gastrointestinal epitheliumGO:03027710.5MUC6, TFF1
5negative regulation of cell proliferationGO:00828510.5TGIF1, IL8, CXCL1, SST, TFF1
6acute inflammatory responseGO:00252610.4S100A8, DEFB1
7response to nutrientGO:00758410.4SST, CCKAR, LTA
8signal transductionGO:00716510.2IL8, CXCL1, LTA, GRP, GAST, CCK
9response to drugGO:04249310.1IL1RN, LTA, TGIF1, SST

Molecular functions related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.4SST, GAST, SCT, CCK

Products for genes affiliated with Duodenal Ulcer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Duodenal Ulcer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet