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Duodenal Ulcer malady
29 drugs, 81 genes, 4 tissues, 971 related diseases, 22 phenotypes, 193 articles, clinical trials.

Summaries for Duodenal Ulcer

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44Wikipedia, 22MalaCards
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Wikipedia: A peptic ulcer, also known as PUD or peptic ulcer disease, is the most common ulcer of an area of the...44 more...

MalaCards: Duodenal Ulcer, also known as stress ulcer, is related to gastritis and gastrinoma. An important gene associated with Duodenal Ulcer is GAST (gastrin), and among its related pathways are Immune response_Bacterial infections in normal airways and Immune System. The drugs calcium (as calcium carbonate) and magnesium hydroxide and the compounds glucose and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and b cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions for Duodenal Ulcer

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 24MeSH, 40SNOMED-CT
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Aliases & Descriptions:

duodenal ulcer 6 8 32 43
stress ulcer 6 32 43
curling ulcer 6 43
acute duodenal ulcer with hemorrhage, with perforation and with obstruction (disorder) 6
acute duodenal ulcer with perforation but without obstruction (disorder) 6
acute duodenal ulcer with hemorrhage and perforation, with obstruction 6
acute duodenal ulcer with perforation, without mention of obstruction 6
chronic duodenal ulcer without hemorrhage and without perforation 6
acute duodenal ulcer with perforation and obstruction (disorder) 6
acute duodenal ulcer with hemorrhage and obstruction (disorder) 6
acute duodenal ulcer with perforation but without obstruction 6
acute duodenal ulcer with perforation, with obstruction 6
acute duodenal ulcer with hemorrhage, with obstruction 6
acute duodenal ulcer with perforation and obstruction 6
acute duodenal ulcer with hemorrhage and obstruction 6
acute duodenal ulcer with hemorrhage and perforation 6
acute duodenal ulcer with perforation (disorder) 6
acute duodenal ulcer with perforation 6
acute duodenal ulcer with hemorrhage 6
curling's ulcers (disorder) 6
du - acute + perforation 6
stress ulcer (disorder) 6
duodenal ulcer disease 32
chronic duodenal ulcer 43
acute duodenal ulcer 43
stress ulcer nos 6

External Ids:

SNOMED-CT40 39755000

Related Diseases for Duodenal Ulcer

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13GeneCards, 14GeneDecks
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Diseases related to duodenal ulcer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 968)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis34.9SCT, S100A8, IL1RN, IL8, DEFB4A, GAST
2gastrinoma30.8SCT, CHGA, INS, GRP, HRH2, SST
3atrophic gastritis30.4SCT, CHGA, S100A8, XDH, IL1RN, AKR1A1
4dyspepsia30.3S100A8, CD14, GRP, IL17A, IL1B, IL1RN
5pancreatic cancer29.6SCT, CHGA, MUC1, MUC6, GRP, CCK
6multiple endocrine neoplasia27.9SCT, CHGA, INS, FGF2, MBL2, HSPA4
7gastroesophageal reflux disease27.8SCT, S100A8, IL1B, IL1RN, IL6, IL8
8gastroduodenitis27.6SERPINA6, SCT, CHGA, MUC1, MUC6, S100A8
9insulinoma26.4SCG5, SCT, CHGA, INS, GSR, GRP
10twinning24.0CHGA, MUC1, S100A8, CFTR, MPO, CD40LG
11duodenitis23.4SERPINA6, SCG5, SCT, CHGA, MUC1, MUC6
12blindness20.8SCT, CHGA, XDH, CFTR, MPO, CD40LG
13polyposis18.9CHGA, MUC1, MUC6, XDH, CFTR, MPO
14gastric cancer18.4CHGA, MUC1, MUC6, S100A8, XDH, MPO
15pancreatitis16.2SERPINA6, SCG5, SCT, CHGA, MUC1, MUC6
16pneumonia15.4MUC1, S100A8, XDH, CFTR, MPO, CD14
17duodenogastric reflux14.0SCT, IL8, CCK, GAST
18pancreatic cholera13.9SST, PPY, GAST
19gastrointestinal system disease13.9SCT, S100A8, CCK, CCKAR, GAST
20peutz-jeghers syndrome13.9MUC6, TFF1, GAST
21bile reflux13.9CCK, TFF1, GAST
22alcoholic pancreatitis13.8SCT, CFTR, CCK, AKR1A1
23steatorrhea13.8SCT, CFTR, CCK, SST
24somatostatinoma13.8CHGA, CALCA, SST, PPY, GAST
25vipoma13.8SCT, CHGA, CALCA, SST, PPY, GAST
26glucose intolerance13.8CFTR, CCK, HRH2, CP, GAST
27exocrine pancreatic insufficiency13.8SCT, CFTR, CCK, PPY
28familial medullary thyroid carcinoma13.8CHGA, GRP, CALCA, SST, ABP1
29primary hyperparathyroidism13.7SCT, CHGA, CALCA, GAST
30thyroid medullary carcinoma13.7CHGA, GRP, CALCA, SST, HDC
31megaloblastic anemia13.7CHGA, DNAH8, PGA3, GAST
32neuroendocrine tumor13.7SCT, CHGA, GRP, CCK, CALCA, SST
33vulvovaginal candidiasis13.7MBL2, DEFB1, DEFB4A
34endocrine gland cancer13.7CHGA, SST, GAST
35postcholecystectomy syndrome13.7CCK, SOD1, GAST
36carcinoid syndrome13.7CHGA, HTR3A, CALCA, SST, PPY, GAST
37tonsillitis13.7DEFB1, DEFB4A, SOD1
38rheumatoid arthritis13.7IL1RN, MBL2, HLA-DRB1, LTA
39gallbladder disease13.7CFTR, CCK, CCKAR
40apudoma13.6MUC1, CALCA, SST, GAST
41cystic fibrosis lung disease13.6CFTR, MPO, IL8, MBL2
42bronchitis13.6S100A8, CFTR, MPO, IL8
43protein-energy malnutrition13.6CFTR, MPO, GSR, CCK, CP
44wermer syndrome13.6SCT, CHGA, SST, PRL, GAST
45pancreatic ductal carcinoma13.6CHGA, MUC6, GRP
46chronic ulcer of skin13.6FGF2, EGF, TIMP2, DEFB4A
47embryonal cancer13.6FGF2, EGF, TGFA
48invasive aspergillosis13.6IL17A, MBL2, PLG, TLR4
49xanthogranulomatous pyelonephritis13.6SCG5, MUC1, EGF
50congenital heart defect13.6MMP3, GSR, IL1RN, HSPA1A, AKR1A1, TLR4

Graphical network of the top 20 diseases related to duodenal ulcer:



Graphical network of diseases related to duodenal ulcer

Clinical Features for Duodenal Ulcer

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Drugs & Therapeutics for Duodenal Ulcer

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for duodenal ulcer

Inferred drug relations via UMLS/NDF-RT:

43 28 aluminum (as hydroxide), aluminum carbonate, aluminum carbonate basic, aluminum hydroxide, aluminum hydroxide gel, aluminum hydroxide gel,dried, aluminum/magnesium hydroxide, amoxicillin, amoxicillin trihydrate, calcium (as calcium carbonate), calcium (as carbonate), calcium carbonate, calcium carbonate pwdr [va product], calcium gluceptate, clarithromycin, dihydroxyaluminum sodium carbonate, esomeprazole, esomeprazole magnesium, esomeprazole sodium, lansoprazole, magaldrate, magnesium hydroxide, maprotiline, maprotiline hydrochloride, milk of magnesia [va product], omeprazole, omeprazole magnesium, prazepam, rabeprazole

Genetic Tests for Duodenal Ulcer

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Anatomical Context for Duodenal Ulcer

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22MalaCards
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MalaCards organs/tissues related to duodenal ulcer:

22
Salivary gland, T cells, B cells, Endothelial

Phenotypes for genes affiliated with Duodenal Ulcer

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25MGI
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MGI Mouse Phenotypes related to duodenal ulcer:

25 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.0CALCA, CD14, CFTR, SCG5
2endocrine/exocrine gland phenotypeMP:000537910.0SCG5, XDH, CD40LG, IL2RB, CCKAR, LTA
3hematopoietic system phenotypeMP:00053979.7CSF2, HDC, TLR5, FGF2, IL17A, IL23A
4renal/urinary system phenotypeMP:00053678.9HIF1A, NOS3, PLG, CTSB, AKR1A1, HTR3A
5other phenotypeMP:00053958.8TGIF1, TLR2, NOS3, CTSB, PTGS2, CD40LG
6integument phenotypeMP:00107718.4TLR2, TLR4, TGFA, PRL, CSF2, HDC
7immune system phenotypeMP:00053877.7HLA-DQA1, HLA-DQB1, TNF, CTSB, PLG, NOD1
8liver/biliary system phenotypeMP:00053707.4HIF1A, TLR2, TLR4, TLR5, PRL, SOD1
9skeleton phenotypeMP:00053907.0PTGS2, PPY, EGR1, HIF1A, TGFA, CSF2
10growth/size phenotypeMP:00053786.9PPY, PLG, NOS3, LTA, EGF, EGR1
11reproductive system phenotypeMP:00053896.9MMP9, FGF2, IL1RN, IL2RB, IL6, AKR1A1
12mortality/agingMP:00107686.9LTA, NOS3, PLG, CTSB, HLA-DQB1, EDN1
13behavior/neurological phenotypeMP:00053866.9TLR2, EGR1, LTA, NOS3, PPY, TLR4
14digestive/alimentary phenotypeMP:00053816.8MMP9, INS, IL17A, IL23A, CCKAR, HRH2
15nervous system phenotypeMP:00036316.5TLR4, TLR2, HIF1A, EDN1, TIMP2, TGFB1
16adipose tissue phenotypeMP:00053756.4TLR4, TLR5, TGFA, TGFB1, CSF2, HDC
17muscle phenotypeMP:00053695.5EDN1, HIF1A, TLR2, TGFA, TGFB1, SOD1
18tumorigenesisMP:00020065.4EGR1, HIF1A, TLR2, TLR4, TIMP1, TGFB1
19vision/eye phenotypeMP:00053915.1LTA, EGF, EGR1, HIF1A, TLR4, TGFA
20cardiovascular system phenotypeMP:00053854.1LTA, EDN1, EGR1, HIF1A, TLR2, TLR4
21cellular phenotypeMP:00053843.5EGR1, LTA, NOS3, PLG, CTSB, PTGS2
22homeostasis/metabolism phenotypeMP:00053763.1SERPINA6, HSPA1B, CAT, CALCA, HRH2, AKR1A1

Publications for genes affiliated with Duodenal Ulcer

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35PubMed
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Articles related to duodenal ulcer:

(show top 50)    (show all 193)
idTitleAuthorsYearAffiliating Genes
1Associations of the IL-1 and TNF gene polymorphisms i n the susceptibility to duodenal ulcer disease in Chinese Han population. (19804405)Mei Q.... Hu Y.M.2010TNF, IL1B, IL1RN
2Polymorphisms in TNF and HSP-70 show a significant as sociation with gastric cancer and duodenal ulcer. (19626584)Partida-RodrA-guez O.... Perez-RodrA-guez M.2010TNF, HSPA1A, LTA
3Influence of three point mutations in TNF-alpha prom oter gene in clinical manifestations and complications of stomach and duodenal ulcer (19548417)Polonikov A.V.... Bulgakova I.V.2009TNF
4The risk of pancreatic cancer in patients with gastric or duodenal ulcer disease. (17044024)Luo J.... Ye W.2007SCT
5Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis. (17309748)Hofner P.... Mandi Y.2007IL8, TLR4, NOD1
6Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. (18001398)Arachchi H.S.... Ahuja V.2007S100A8
7The part of the hormone-cyclase system in achieving the therapeutic effect of hydrochloric acid secretion inhibitors at the duodenal ulcer (16866262)Vahrushev I.a.M.... Muravtseva O.V.2006GAST
8Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer. (17106939)Erzin Y.... Kocazeybek B.2006S100A8
9Down-regulation of epithelial IL-8 responses in Helicobacter pylori-infected duodenal ulcer patients depends on host factors, rather than bacterial factors. (15762883)StrAPmberg E.... Lindholm C.2005IL8
10Response of blood endothelin-1 and nitric oxide activity in duodenal ulcer patients undergoing Helicobacter pylori eradication. (15742413)Chang F.Y.... Lee S.D.2005EDN1
11Efficacy of galavit in patients with duodenal ulcer (16218370)Butorov I.V.... Butorov S.I.2005SOD1, CAT
12TNF/LTA polymorphisms and risk for gastric cancer/duodenal ulcer in the Korean population. (15381184)Lee S.G.... Song K.2004TNF, IL1RN, LTA
13Genetic polymorphism of interleukin-8 (IL-8) is associated with Helicobacter pylori-induced duodenal ulcer. (15627645)Gyulai Z.... Mandi Y.2004IL8, CD14
14Association between Helicobacter pylori virulence and duodenal ulcer disease in patients from Hong Kong in China (12697114)Yin Y.... Lin Z.X.2003S100A8
15Effect of quamatel on neutrophil properties, parameters of lipid peroxidation and the antioxidant defense system in blood of patients with duodenal ulcer and pancreatitis (14743716)Artiukhov V.G.... Basharina O.V.2003SOD1, GSR
16Association of interleukin 1 gene family polymorphisms with duodenal ulcer disease. (14632761)Garcia-Gonzalez M.A.... Pena A.S.2003IL1B, IL1RN
17Bleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene. (12018926)Serrano T.... Lanas A.2002NOS3
18Effect of rebamipide in treatment of Helicobacter pyl ori-associated duodenal ulcer: attenuation of chemokine expression and nitrosat ive damage. (11855542)Choi K.W.... Kim J.H.2002IL8, CCL5
19Presence of gastric autoantibodies impairs gastric secretory function in patients with Helicobacter pylori-positive duodenal ulcer. (11346199)Parente F.... Bianchi Porro G.2001GAST
20Hypersecretory duodenal ulcer and Helicobacter pylori infection: a four-year follow-up study. (10975785)Capurso G.... Delle Fave G.2000GAST
21HLA-DQA1 genes involved in the genetic susceptibility to duodenal ulcer in Wuhan Hans (10194252)Du Y.... Hou W.1999HLA-DQA1
22Comparison of meal-stimulated serum gastrin response in Helicobacter pylori-positive duodenal ulcer and asymptomatic volunteers with and without H. pylori infection. (10469191)Kamada T.... Kajiyama G.1999GAST
23The acid response to gastrin distinguishes duodenal ulcer patients from Helicobacter pylori-infected healthy subjects. (9428218)Gillen D.... McColl K.E.1998GAST
24Epidermal growth factor and transforming growth factor alpha in duodenal ulcer and non-ulcer dyspepsia patients before and after Helicobacter pylori eradication. (9517524)Konturek P.C.... Hahn E.G.1998EGF, TGFA
25Effect of curing Helicobacter pylori infection on intragastric acidity during treatment with ranitidine in patients with duodenal ulcer. (9274468)Labenz J.... Blum A.L.1997GAST
26Identifiable Helicobacter pylori strains or factors important in the development of duodenal ulcer disease. (9432351)Figura N.1997AKR1A1
27Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients. (8777296)Konturek J.W.... Domschke W.1996CCKAR, SST, CCK
28Helicobacter pylori infection and basal levels of serum gastrins in patients with duodenal ulcer and subjects with normal endoscopy (8667697)Gisbert J.P.... MartA-n De Argila C.1996GAST
29Il-2 receptor expression on gastric mucosa T lymphocytes is enhanced in duodenal ulcer patients compared with non-ulcer dyspeptic patients. (8975986)Ihan A.... Gubina M.1996IL2RB
30Helicobacter pylori and duodenal ulcer: evidence for a histamine pathways-involving link. (8931414)Bechi P.... Masini E.1996GAST
31Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin. (8707109)Harris A.W.... Baron J.H.1996GRP
32Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients. (7481540)Konturek J.W.... Domschke W.1995CCK, GAST
33Multiple endocrine neoplasia type 1 presenting as insulinoma, gastrinoma, and postbulbar duodenal ulcers: report of a case. (8555708)Murakami S.... Miura S.1995GAST
34Effect of vagotomy on cholecystokinin release and gallbladder contraction in patients with complicated duodenal ulcer. (7851462)Huang Y.S.... Rayford P.L.1994CCK
35Effect of systemic gastric acid stimulation and intragastric pH changes on synchronous antral gastrin and somatostatin release in anesthetized, nonatropinized duodenal ulcer patients and controls. (7924733)FerahkAPA9e Z.... MenteA9 B.B.1994SST, GAST
36A controlled study of ranitidine for the prevention of recurrent hemorrhage from duodenal ulcer. (8284002)Jensen D.M.... Silpa M.1994HRH2
37Variations of plasma gastrin (basal and postprandial) in ththtreatmentof duodenal ulcer with either enprostil or ranitidine. Correlations with rates of relapse (7875420)Bado A.... Vicari F.1994GAST
38Endogenous CCK in the control of gastric secretory response to meal in normal subjects and duodenal ulcer patients. (8185212)Konturek J.W.... Konturek S.J.1994CCK
39Helicobacter pylori in duodenal ulcer patients with idiopathic gastric acid hypersecretion. (8420745)Collen M.J.... Strong R.M.1993SCT
40Characteristics of teen-age patients with juvenile duodenal ulcer. Relation between inherited hyperpepsinogenemia I and duodenal ulcer. (8430271)Kimura M.... Kajiyama G.1993GAST
41Changes of IgA, IgG and IgM immunoglobulins and of 10 other plasma proteins in patients with duodenal ulcer treated with ranitidine (8249388)PrzybyA8owski J.... Kolus D.1993CD40LG
42Acute effects of smoking during modified sham feeding in duodenal ulcer patients. An analysis of nicotine, acid secretion, gastrin, catecholamines, epidermal growth factor, prostaglandin E2, and bile acids. (8322024)Lindell G.... Graffner H.1993EGF, GAST
43An experimental study of adrenalin-stimulated gastric acid secretion and gastrin secretion in rats of cysteamine-induced duodenal ulcer (1578802)Koga S.... Aoki T.1992GAST
44Determination of basal and stimulated blood gastrin in duodenal ulcer (1485981)NA_A+ez PeA+a J.R.... Tamames E.S.1992GAST
45Effect of duodenal ulcer healing induced by omeprazole and ranitidine on the generation of gastroduodenal eicosanoids, platelet-activating factor, pepsinogen A, and gastrin in duodenal ulcer patients. (1736336)Lysy J.... Rachmilewitz D.1992GAST
46Ultrastructural morphometry of gastric endocrine cells before and after omeprazole. A study in the oxyntic mucosa of duodenal ulcer patients. (2019362)D'Adda T.... Bordi C.1991CHGA
47Gastric acid, gastrin and pancreatic polypeptide resp onses to modified sham feeding in duodenal ulcer patients before and after high ly selective or truncal vagotomy. (2102978)Szafran H.... Konturek S.J.1990GAST
48Ceruloplasmin activity in blood serum in stomach and duodenal ulcers (1966196)Sorokin A.B.... Chernogubova E.A.1990CP
49Effect of alkalies on gastric acidity in patients with duodenal ulcer (2075140)Mach T.1990GAST
50Effect of calcitonin on gastric emptying and postprandial secretion of gastrin and insulin in patients with duodenal ulcer (2098841)Jonderko G.... GoA8ab T.1990CALCA, GAST

Expression for genes affiliated with Duodenal Ulcer

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Duodenal Ulcer

Pathways for genes affiliated with Duodenal Ulcer

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41Thomson Reuters, 38Reactome, 20KEGG, 36QIAGEN, 10EMD Millipore, 37R&D Systems, 3Cell Signaling Technology
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Pathways related to duodenal ulcer according to GeneDecks:

(show top 50)    (show all 129)
idPathwayScoreTop Affiliating Genes
1Immune response_Bacterial infections in normal airways4110.3CFTR, CD14, IL1B, TLR5, DEFB4A
2Immune System3810.2CTSB, DEFB4A, EGR1, TLR5, DEFB1, CSF2
3Graft-versus-host disease2010.1HLA-A, HLA-DQA1, HLA-B
4Bacterial infections in CF airways4110.0TLR2, CTSB, CFTR, MUC1, TLR5, DEFB4A
5IL-6 Pathway369.9IL23A, CCL5, TIMP1, CXCL1, CSF2, IL8
6Endothelin-1 Signaling Pathway369.7IL6, EDN1, CXCL1, CCL5, IL1B, IL23A
7Antigen processing and presentation209.7HLA-DRB1, CTSB, HLA-DQB1, HLA-DQA1, HSPA4, HSPA1L
8Akt Signaling369.7CSF2, IL23A, IL2RB, IL6, CCL5, TNF
9Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)419.7CP, SOD1, HSPA4, HSPA1L, HSPA1B, HSPA1A
10Cytokine production by Th17 cells in CF419.6CD14, CSF2, CXCL1, TLR4, IL8, IL6
11Pertussis209.5IL23A, NOD1, TNF, TLR4, IL6, CD14
12Toll-like receptor signaling pathway209.3IL8, TNF, IL6, CCL5, TLR2, CD14
13Allograft rejection209.2CD40LG, HLA-A, HLA-DRB1, HLA-B, HLA-DQA1, HLA-DQB1
14NOD-like receptor signaling pathway209.1TNF, CCL5, IL8, IL1B, NOD1, IL6
15Immune response_MIF in innate immunity response419.0TLR4, PTGS2, TNF, IL8, IL6, CD14
16Immune response MIF in innate immunity response109.0IL6, CD14, IL1B, TLR4, PTGS2, TNF
17Influenza A208.9TLR4, HSPA1B, HSPA1L, HLA-DQA1, HLA-DQB1, HLA-DRB1
18all-trans-Retinoic Acid Signaling in Brain368.9CSF2, IL8, CCL5, TNF, PTGS2, LTA
19IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types378.9IL23A, TGFB1, IL6, TLR5, IL17A, IL1B
20Th17 Differentiation378.8IL6, TLR4, IL23A, IL1B, IL17A, TGFB1
21Phagosome208.8HLA-DRB1, TLR2, TLR4, HLA-DQA1, HLA-A, CD14
22Immune response IL-1 signaling pathway108.8TNF, IL1B, IL6, IL8, PTGS2, CP
23MIF Mediated Glucocorticoid Regulation368.8CCL5, CD14, IL1B, IL23A, IL6, IL8
24MIF Regulation of Innate Immune Cells368.8CSF2, CXCL1, TLR4, LTA, PTGS2, TNF
25Type I diabetes mellitus208.8LTA, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B
26Cytokine production by Th17 cells in CF (Mouse model)418.8CSF2, CXCL1, TGFB1, TLR4, IL8, IL6
27Immune response_IL-1 signaling pathway418.7IL1B, IL6, IL8, TNF, PTGS2, CP
28Malaria208.6CD40LG, IL1B, IL6, IL8, TNF, TLR2
29Rho Family GTPases368.6IL23A, CCL5, CSF2, TGFA, CXCL1, TGFB1
30Toxoplasmosis208.6TLR2, TLR4, TGFB1, HLA-DRB1, TNF, HLA-DQB1
31Amoebiasis208.5CXCL1, TLR2, IL1B, IL6, CD14, IL8
32ERK Signaling368.4CXCL1, TGFB1, IL1B, TIMP2, TIMP1, EGF
33Leishmaniasis208.2TLR4, TLR2, TNF, HLA-DRB1, HLA-DQA1, IL1B
34TGF-Beta Pathway368.2IL6, CCL5, IL23A, IL1B, FGF2, EGF
35Tuberculosis208.1HLA-DQB1, HLA-DQA1, IL1B, CD14, IL6, HLA-DRB1
36Apoptotic Pathways in Synovial Fibroblasts368.1TIMP2, FGF2, IL6, TNF, LTA, EGF
37PAK Pathway368.0TNF, IL1B, FGF2, TIMP1, TIMP2, TGFA
38MAPK Family Pathway368.0TIMP1, FGF2, IL1B, IL23A, LTA, TGFB1
39Cytokine-cytokine receptor interaction208.0EGF, TGFB1, PRL, CD40LG, CXCL1, CSF2
40NF-KappaB (p50-p65) Pathway368.0TIMP1, FGF2, IL1B, IL6, TNF, LTA
41NF-KappaB Family Pathway368.0TLR4, EGF, LTA, TGFB1, TGFA, TIMP2
42Antioxidant Action of Vitamin-C367.8IL2RB, TGFB1, CXCL1, TGFA, TIMP2, LTA
43p38 Signaling367.8CSF2, CXCL1, TGFB1, TGFA, TIMP2, TIMP1
44Colorectal Cancer Metastasis367.8MMP7, TGFB1, TLR5, TLR2, EGF, PTGS2
45Molecular Mechanisms of Cancer367.8EGF, HIF1A, LTA, IL6, CCL5, IL23A
46Rheumatoid arthritis207.8IL8, HLA-DRB1, HLA-DQB1, CCL5, IL6, IL23A
47Tec Kinases Signaling367.7FGF2, IL1B, IL23A, IL2RB, IL6, TLR2
48JAK-STAT Pathway367.7PRL, TIMP2, TIMP1, CCL5, IL8, IL6
49Angiogenesis37.6PTGS2, TGFA, FGF2, MMP9, MMP7, NOS3
50Pancreatic Adenocarcinoma367.1TGFB1, MMP7, MMP3, FGF2, IL6, PTGS2

Compounds for genes affiliated with Duodenal Ulcer

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32Novoseek , 42Tocris Bioscience, 34PharmGKB, 9DrugBank, 18HMDB
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Compounds related to duodenal ulcer according to GeneDecks:

(show top 50)    (show all 485)
idCompoundScoreTop Affiliating Genes
1glucose32 10.5SCT, HSPA1A, PLG, GAST, DEFB1, TFF1
2endotoxin32 10.4CXCL1, DEFB4A, ABP1, LTA, HRH2, HSPA1A
3omeprazole32 42 34 9 18 9 15.3GAST, HDC, DNAH8, SST, CYP2C19, HRH2
4l-nmma32 10.1CCK, IL1RN, XDH, CAT, EDN1, SOD1
5hyaluronic acid32 18 11.0TIMP2, LTA, FGF2, MMP3, MUC1, TFF1
6peptidoglycan32 9.7DEFB4A, TLR5, TLR4, TLR2, NOD1, TNF
7dmso32 9.5SOD1, DNAH8, CTSB, HSPA4, MMP7, MMP3
8progesterone32 42 9 18 9 13.4EGF, CYP2C19, HSPA4, HSPA1A, MMP7, MUC6
9h2o232 9.4HDC, CSF2, TFF1, TGIF1, TLR4, ABP1
10polymyxin b32 9.4IL8, IL6, IL1RN, IL1B, CD14, MBL2
11dopamine32 9 18 9 12.2SCT, CFTR, HDC, CP, TGIF1, ABP1
12n acetylcysteine32 9.2TIMP1, TLR4, HIF1A, EGR1, PLG, IL2RB
13neopterin32 9.2CD14, CSF2, LTA, CTSB, TNF, MBL2
14lipoteichoic acid32 9.1DEFB4A, TLR5, TLR4, TLR2, LTA, TNF
15s-nitroso-n-acetylpenicillamine32 8.8XDH, IL1B, CP, SOD1, HIF1A, EGR1
16acth32 8.7GAST, PRL, SST, CCK, IL6, IL2RB
17calcium32 9 18 9 11.5CCKAR, CCK, GRP, MMP7, CD14, MPO
18epinephrine32 9 18 9 11.5CXCL1, SCT, DNAH8, TGFA, EGR1, HRH2
19thapsigargin32 42 9.3NOS3, CTSB, HSPA4, HSPA1A, CCL5, CCK
20pge232 8.2EGR1, EGF, EDN1, CTSB, SST, CCL5
218-isoprostane32 8.1SOD1, EDN1, NOS3, TNF, CAT, HSPA1A
22tamoxifen32 34 9 9 11.0TIMP2, HIF1A, EGR1, EGF, NOS3, CYP2C19
23fibrinogen32 7.9CP, TIMP2, TLR4, TLR2, EGR1, PLG
24glutamate32 7.9AKR1A1, CALCA, HSPA4, CCL5, GRP, GSR
25prostaglandin32 7.7TNF, HRH2, HSPA4, CCL5, IL6, IL1RN
26cysteine32 7.7EGR1, EGF, CTSB, AKR1A1, CCL5, MMP9
27adenylate32 7.6GAST, CP, CXCL1, DNAH8, GRP, GSR
28hydrocortisone32 9 9 9.6TGFA, EGF, SST, TNF, CALCA, CCL5
29superoxide32 18 8.5HSPA1A, MBL2, IL8, IL2RB, IL1RN, IL1B
30sb 20358032 42 8.5EGR1, EGF, EDN1, NOS3, TNF, HSPA4
31testosterone32 9 18 9 10.5GRP, MMP9, CD40LG, CFTR, MUC1, CHGA
32herbimycin a32 42 8.3LTA, PTGS2, TNF, HSPA4, IL8, IL6
33estrogen32 7.2CTSB, CYP2C19, AKR1A1, CALCA, HSPA1A, IL1RN
34rantes32 7.2HDC, IL17A, MMP9, MMP3, CD40LG, CD14
35cholesterol32 9 18 9 10.0MBL2, IL6, IL2RB, IL1RN, INS, MMP3
36butyrate32 7.0DNAH8, TGFB1, TGFA, TIMP2, TIMP1, HIF1A
37thymidine32 18 7.9HIF1A, EGR1, EGF, EDN1, PLG, CTSB
38creatinine32 6.9CP, IL1RN, IL17A, MMP9, MMP3, CD40LG
39pdtc32 6.8HIF1A, PTGS2, TNF, CAT, CCL5, IL8
40methotrexate32 34 42 9 9 10.8TIMP2, MUC1, S100A8, MMP3, TIMP1, HIF1A
41ly29400232 6.7TIMP2, TIMP1, TLR4, CTSB, PTGS2, TNF
42lipid32 6.4IL23A, IL1RN, IL17A, GSR, INS, MMP3
43retinoic acid32 42 18 7.7HDC, CP, CTSB, SST, CYP2C19, TNF
44genistein32 9 18 9 8.7CSF2, DEFB4A, TFF1, TGIF1, TGFA, TIMP2
45alanine32 5.3HDC, DNAH8, TGFA, TIMP2, TIMP1, TLR4
46indomethacin32 9 9 7.2CP, SOD1, DNAH8, CAT, HSPA4, CCL5
47pd 98,05932 4.9CSF2, CXCL1, DEFB4A, TGFB1, TGFA, TIMP2
48lactate32 4.8CHGA, XDH, CP, CSF2, SOD1, TGIF1
49vegf32 4.5CSF2, CXCL1, TFF1, TGIF1, TGFB1, TIMP2
50actinomycin d32 4.4HDC, CSF2, CXCL1, TFF1, TGFB1, TGFA

GO Terms for genes affiliated with Duodenal Ulcer

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12Gene Ontology
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Cellular components related to duodenal ulcer according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transport vesicle membraneGO:0306589.8CHGA, HLA-DQA1, HLA-DQB1, HLA-DRB1
2external side of plasma membraneGO:0098979.3TLR4, TLR2, CTSB, TNF, HLA-DRB1, IL2RB
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.3HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
4secretory granuleGO:0301419.2IL1B, INS, MPO, CHGA, SCG5
5ER to Golgi transport vesicle membraneGO:0125079.2HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
6Golgi lumenGO:0057968.7DEFB4A, DEFB1, TGFB1, INS, MUC6, MUC1
7extracellular spaceGO:0056155.4PGC, MBL2, IL8, IL6, IL1RN, IL1B
8extracellular regionGO:0055764.8GAST, SCG5, IL8, IL6, IL1B, GRP

Biological processes related to duodenal ulcer according to GeneDecks:

(show top 50)    (show all 67)
idNameGO IDScoreTop Affiliating Genes
1chronic inflammatory response to antigenic stimulusGO:00243910.7IL1B, IL1RN
2digestionGO:00758610.5PGC, TFF1, PPY, SST, HTR3A, CCKAR
3positive regulation of osteoclast differentiationGO:04567210.4IL17A, IL23A, CCL5, TNF
4negative regulation of growth of symbiont in hostGO:04413010.3TLR2, LTA, TNF, MBL2
5positive regulation of tumor necrosis factor productionGO:03276010.3TLR4, TLR2, NOD1, IL23A, CD14
6positive regulation of NF-kappaB import into nucleusGO:04234610.2TLR4, TLR2, TNF, IL23A, IL1B
7positive regulation of interferon-gamma productionGO:03272910.2TLR4, LTA, TNF, IL23A, IL1B, CD40LG
8positive regulation of interleukin-8 productionGO:03275710.2TLR5, TLR4, TLR2, CALCA, IL1B
9tissue remodelingGO:04877110.2MMP9, IL23A, PLG
10positive regulation of interleukin-12 productionGO:03273510.0TLR4, TLR2, IL23A, CD40LG
11extracellular matrix disassemblyGO:02261710.0TIMP2, TIMP1, PLG, MMP9, MMP7, MMP3
12defense response to Gram-negative bacteriumGO:05082910.0TLR4, IL6, IL23A, MMP7
13innate immune responseGO:0450879.9DEFB4A, DEFB1, TLR5, TLR4, TLR2, NOD1
14positive regulation of fever generationGO:0316229.8PTGS2, TNF, CCL5, IL1B
15activation of MAPK activityGO:0001879.8SOD1, TGFA, TLR4, NOD1, TNF, IL1B
16detection of bacteriumGO:0160459.8NOD1, HLA-DRB1, HLA-B, HLA-A
17defense response to Gram-positive bacteriumGO:0508309.7TLR2, LTA, NOD1, TNF, MBL2, IL6
18cellular response to interleukin-1GO:0713479.7HIF1A, EDN1, CCL5, IL8, IL17A, MMP9
19response to ethanolGO:0454719.7SOD1, TLR4, NOS3, CTSB, MMP9, S100A8
20positive regulation of mitosisGO:0458409.7TGFA, EGF, EDN1, TNF, IL1B, INS
21positive regulation of interleukin-6 productionGO:0327559.7TLR4, TLR2, NOD1, TNF, IL6, IL1B
22extracellular matrix organizationGO:0301989.7TIMP2, TIMP1, PLG, TNF, MMP9, MMP7
23response to lipopolysaccharideGO:0324969.5TLR4, EDN1, LTA, PTGS2, CCKAR, MMP9
24positive regulation of chemokine productionGO:0327229.5TLR4, TLR2, HIF1A, TNF, IL6
25embryo implantationGO:0075669.5SOD1, PTGS2, CALCA, IL1B, MMP9
26positive regulation of cytokine secretionGO:0507159.4TLR2, TNF, INS, CD14
27anti-apoptosisGO:0069169.4SOD1, TGFA, NOS3, TNF, HSPA1B, IL1B
28response to heatGO:0094089.4SOD1, NOS3, SST, CALCA, HSPA4, CCKAR
29cell-cell signalingGO:0072679.2EDN1, LTA, SST, CALCA, CCL5, IL1B
30regulation of blood pressureGO:0082179.2SOD1, NOS3, PTGS2, CALCA, CHGA
31response to glucocorticoid stimulusGO:0513849.2PTGS2, TNF, HNMT, CCL5, CCKAR, IL6
32positive regulation of angiogenesisGO:0457669.1HIF1A, NOS3, CCL5, IL1B, FGF2, MMP9
33positive regulation of cell divisionGO:0517819.1TGFB1, TGFA, CAT, IL1B, FGF2
34wound healingGO:0420609.1TGFA, IL1B, FGF2, INS, S100A8
35lipopolysaccharide-mediated signaling pathwayGO:0316639.0TGFB1, TLR4, TLR2, NOS3, TNF, CCL5
36positive regulation of nitric oxide biosynthetic processGO:0454299.0TLR4, TLR2, EDN1, PTGS2, TNF, IL1B
37MAPK cascadeGO:0001659.0TGFB1, TGFA, TNF, CCL5, IL1B, INS
38positive regulation of apoptotic processGO:0430659.0SOD1, TLR4, NOS3, PTGS2, TNF, CCK
39immune responseGO:0069558.9TLR2, TLR4, DEFB1, DEFB4A, CXCL1, CSF2
40agingGO:0075688.9TGFB1, TIMP1, NOS3, CALCA, CCL5, IL1B
41positive regulation of smooth muscle cell proliferationGO:0486618.9HIF1A, EDN1, PTGS2, TNF, CCL5, IL6
42cytokine-mediated signaling pathwayGO:0192218.7EGR1, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A
43positive regulation vascular endothelial growth factor productionGO:0105758.7IL1B, PTGS2, HIF1A, TGFB1
44response to estradiol stimulusGO:0323558.5TFF1, TGFB1, NOS3, PTGS2, IL1B, MMP9
45response to hypoxiaGO:0016668.2TGFB1, TLR4, HIF1A, EDN1, LTA, NOS3
46positive regulation of NF-kappaB transcription factor activityGO:0510928.2TGFB1, TLR4, TLR2, NOD1, TNF, CAT
47response to drugGO:0424937.9EDN1, ABP1, TGFA, TGFB1, TGIF1, SOD1
48positive regulation of cell proliferationGO:0082847.6TGFB1, TIMP1, EGF, EDN1, CCK, IL6
49negative regulation of cell proliferationGO:0082857.6PLG, NOS3, TIMP2, TGFB1, TGIF1, CXCL1
50inflammatory responseGO:0069547.5S100A8, CXCL1, TGFB1, TLR5, TLR2, NOD1

Molecular functions related to duodenal ulcer according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.9TLR5, IL1RN, IL1B
2MHC class II receptor activityGO:0323959.9HLA-DQA1, HLA-DQB1, HLA-DRB1
3hormone activityGO:0051799.2SCT, GAST, PRL, EDN1, PPY, SST
4receptor bindingGO:0051029.1CXCL1, LTA, PPY, HLA-B, HLA-A, CALCA
5cytokine activityGO:0051258.7CSF2, EDN1, LTA, TNF, IL6, IL23A
6growth factor activityGO:0080838.2CSF2, CXCL1, TFF1, TGFB1, TGFA, EGF

Sources for Duodenal Ulcer

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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