MCID: DDN001
MIFTS: 53

Duodenal Ulcer malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Duodenal Ulcer

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MalaCards based summary: Duodenal Ulcer, also known as stress ulcer, is related to dyspepsia and gastritis. An important gene associated with Duodenal Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Defensins and Peptide ligand-binding receptors. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and pancreas, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Duodenal Ulcer

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 25ICD10
See all sources

Duodenal Ulcer, Aliases & Descriptions:

Name: Duodenal Ulcer 9 11 43 60
Stress Ulcer 9 43 60
Curling Ulcer 9 60
Du - Acute + Perforation 9
 
Stress Ulcer of Stomach 60
Duodenal Ulcer Disease 43
Curling's Ulcers 9
Stress Ulcer Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:1724
MeSH33 D004381
SNOMED-CT55 39755000
ICD1025 K26

Related Diseases for Duodenal Ulcer

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Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1dyspepsia31.3HRH2, CCK
2gastritis31.3IL1RN, SCT, DEFB4A
3pancreatitis31.3CCK, SST, SCT
4duodenogastric reflux31.2CCK
5zollinger-ellison syndrome31.0SCT, SST, HRH2
6atrophic gastritis30.9SCT, SST, IL1RN
7gastroesophageal reflux30.8HRH2, CCK, SCT
8pancreatic cancer30.8CCK, SST, SCT
9dumping syndrome30.7SST
10gastrinoma30.7SCT, SST
11alcoholic pancreatitis30.5CCK, SCT
12pancreas disease30.5CCK, SCT
13multiple endocrine neoplasia 130.5SST, SCT
14steatorrhea30.3SCT, SST, CCK
15pneumonia30.2HRH2, DEFB1, DEFB4A
16acute pancreatitis30.1SCT, SST, CCK, IL1RN, HRH2
17neuroendocrine tumor30.1HDC, SST
18periodontal disease30.1DEFB4A, DEFB1, IL1RN
19nephritis30.0LTA, IL1RN
20adenocarcinoma29.8SCT, MUC6, SST, CCK
21periodontitis29.8LTA, IL1RN, DEFB1, DEFB4A
22cystic fibrosis29.7DEFB4A, DEFB1, SCT, MUC6
23stomach cancer29.7HDC, MUC6, CCK, IL1RN, HRH2
24peptic ulcer disease29.6HDC, SCT, SST, CCK, HRH2
25duodenitis11.5
26esophagitis10.6
27h. pylori infection10.6
28gastroduodenitis10.6
29gastric ulcer10.5
30fibrinogen deficiency, congenital10.5
31blindness10.5
32angiodysplasia10.5SST
33duodenal ulcer due to antral g-cell hyperfunction10.4
34gastric outlet obstruction10.4
35oral candidiasis10.4DEFB4A
36hepatitis10.3
37hiatus hernia10.3
38hyperinsulinemic hypoglycemia, familial, 210.3SCT, SST
39exocrine pancreatic insufficiency10.3SCT, CCK
40candidiasis10.3DEFB4A
41vipoma10.3SST, SCT
42gastrointestinal system disease10.3CCK, SCT
43glucose intolerance10.3HRH2, CCK
44cholelithiasis10.3SST, CCK
45short bowel syndrome10.3CCK, SST
46gastrojejunal ulcer10.3
47meckel's diverticulum10.3
48arteriovenous malformation10.3
49bile reflux10.3
50peptic esophagitis10.3

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to duodenal ulcer

Symptoms for Duodenal Ulcer

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Genetic Tests for Duodenal Ulcer

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Anatomical Context for Duodenal Ulcer

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MalaCards organs/tissues related to Duodenal Ulcer:

31
Liver, Colon, Pancreas, Testes, Heart, Endothelial, Neutrophil, Kidney, Thyroid, Monocytes, T cells, Small intestine

Animal Models for Duodenal Ulcer or affiliated genes

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MGI Mouse Phenotypes related to Duodenal Ulcer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8LTA, HRH2, CCK, SST, SCT, HDC
2MP:00053767.1LTA, HDC, SCT, SST, CCK, IL1RN

Publications for Duodenal Ulcer

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Articles related to Duodenal Ulcer:

(show top 50)    (show all 762)
idTitleAuthorsYear
1
Thyroid storm precipitated by duodenal ulcer perforation. (25838951)
2015
2
Non-healing gastro-duodenal ulcer: A rare presentation of primary abdominal tuberculosis. (25506841)
2015
3
An unusual case of metastatatic renal cell carcinoma presenting as melena and duodenal ulcer, 16 years after nephrectomy; a case report and review of the literature. (25821299)
2015
4
Closure of a perforated duodenal ulcer by over-the-scope clip. (25028271)
2014
5
Helicobacter pylori from gastric cancer and duodenal ulcer show same phylogeographic origin in the Andean region in Colombia. (25121764)
2014
6
Laparoscopy for perfored duodenal ulcer : conversion and morbidity factors: Retrospective study of 290 cases. (25879598)
2014
7
Acute mesenteric ischemia and duodenal ulcer perforation: a unique double pathology. (23110681)
2012
8
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
9
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. (21220246)
2011
10
Antiulcer activity of Andrographis paniculata (Burm.f.) wall. against cysteamine-induced duodenal ulcer in rats. (21800503)
2011
11
Recurrent duodenal ulcer due to nonsteroidal anti-inflammatories following the suspension of antiulcer medication. (19938884)
2009
12
Duodenal ulcer due to yttrium microspheres used for selective internal radiation therapy of hepatocellular cancer. (18950763)
2009
13
Bleeding duodenal ulcer with a right upper quadrant mass. (18268056)
2008
14
Interleukin-1beta gene polymorphism as a predictor of eradication treatment efficacy in gastric and duodenal ulcer associated with Helicobacter pylori]. (19145908)
2008
15
Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (18809506)
2008
16
Pattern of change in the frequency of Helicobacter pylori with perforated duodenal ulcer. (19999201)
2008
17
Changes in reducing power profile of gastric juice in patients with active duodenal ulcer. (16095868)
2005
18
Deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer: a correlated study. (15793868)
2005
19
Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries. (15866209)
2005
20
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
21
Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: study by 24-h pH monitoring in patients with gastric or duodenal ulcer. (15870971)
2005
22
Surgical management of perforated duodenal ulcer: the changing scene. (15816264)
2004
23
Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infected duodenal ulcer patients. (12522049)
2003
24
Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy. (14512101)
2003
25
Effect of Helicobacter pylori eradicated therapy on water gastric emptying in patients with active duodenal ulcer. (14535981)
2003
26
Association between Helicobacter pylori virulence and duodenal ulcer disease in patients from Hong Kong in China]. (12697114)
2003
27
The sixth decision regarding perforated duodenal ulcer. (12500837)
2002
28
Relationship between the birth cohort pattern of Helicobacter pylori infection and the epidemiology of duodenal ulcer. (12145391)
2002
29
Detection of Helicobacter pylori-associated asymptomatic duodenal ulcer in a boy. (11982907)
2002
30
14C urea breath test does not predict density of Helicobacter pylori in duodenal ulcer disease. (11558321)
2001
31
Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer? (11421880)
2001
32
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. (11507979)
2001
33
Helicobacter pylori infection in patients with perforated chronic duodenal ulcer. (11676339)
2001
34
Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. (10930902)
2000
35
Smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients in Taiwan. (10548360)
1999
36
Effect of chronic duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF receptor expression in humans. (9881512)
1998
37
Effect of curing Helicobacter pylori infection on intragastric acidity during treatment with ranitidine in patients with duodenal ulcer. (9274468)
1997
38
Presence of the cagA gene in the majority of Helicobacter pylori strains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis. (9398887)
1996
39
Helicobacter pylori and duodenal ulcer: evidence for a histamine pathways-involving link. (8931414)
1996
40
Immunogenetic analysis of the human leukocyte antigen DQA1 locus in patients with duodenal ulcer or chronic atrophic gastritis harbouring Helicobacter pylori. (8574742)
1995
41
Prospective randomized study comparing three surgical techniques for the treatment of gastric outlet obstruction secondary to duodenal ulcer. (8101050)
1993
42
pH-dependent secretion of gastrin in duodenal ulcer disease: effect of suppressing Helicobacter pylori. (1459351)
1992
43
Patients with duodenitis have gastric secretory and motor functions like those of duodenal ulcer patients: results of a short-term treatment with ranitidine. (2066545)
1991
44
Ceruloplasmin activity in blood serum in stomach and duodenal ulcers]. (1966196)
1990
45
Long-term treatment for gastric and duodenal ulcer. (1983413)
1990
46
Oxyntic mucosa histology in omeprazole-treated patients suffering from duodenal ulcer or Zollinger-Ellison syndrome. (3792669)
1986
47
Use of a provocation test for objective assessment of dumping syndrome in patients undergoing surgery for duodenal ulcer. (7468560)
1980
48
Bleeding duodenal ulcer as a complication of treatment of status asthmaticus with adrenal corticosteroids. (6967706)
1980
49
Gastritis, duodenitis, and bleeding duodenal ulcer following mefenamic acid therapy. (949194)
1976
50
A five-to ten-year follow-up study of the Billroth I and Billroth II (polya) operations for duodenal, gastric and gastrojejunal ulcer and gastroenterostomy with vagotomy in the treatment of duodenal ulcer. (13480410)
1957

Variations for Duodenal Ulcer

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Expression for genes affiliated with Duodenal Ulcer

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Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for genes affiliated with Duodenal Ulcer

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Compounds for genes affiliated with Duodenal Ulcer

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Compounds related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1epft4310.2CCK, SCT
2l-bpa4310.1SCT, CCK
3caerulein4310.1SCT, CCK
4pancreozymin4310.1SCT, CCK
5cerulein4310.0CCK, SCT
6minigastrin4310.0CCK, SST
7enprostil43 2811.0HRH2, SST
8vapreotide43 28 1211.9SST, CCK
9pepsinogen439.9SCT, CCK, HRH2
10ranitidine43 28 24 1212.9CCK, SCT, HRH2
11lafutidine439.9SST, SCT, HRH2
12alosetron43 1210.9SST, CCK
13tetrodotoxin43 59 2811.8HRH2, SCT, CCK
14taurodeoxycholate439.8SCT, CCK, SST
15bicarbonate439.8HRH2, CCK, SCT
16loxiglumide439.8CCK, SCT, SST
17pirenzepine43 28 1211.8HRH2, SST, CCK
18benzodiazepines439.8CCK, HRH2
19oxyntomodulin43 5910.8CCK, SST, SCT
20octreotide43 59 28 1212.7SST, SCT, CCK
21c-peptide439.7CCK, SCT, SST
22triprolidine43 28 1211.7HDC, HRH2
23glipizide43 49 1211.7SST, HRH2
24atropine43 28 1211.5HRH2, SCT, SST, CCK
25epinephrine43 24 1211.5SCT, SST, HRH2, IL1RN
26lipoteichoic acid439.4IL1RN, LTA, DEFB4A
27acth439.4IL1RN, SCT, SST, CCK
28bethanechol43 28 1211.4SST, CCK
29norepinephrine43 24 1211.4CCK, IL1RN, SST, SCT
30forskolin43 49 1211.3HRH2, LTA, SCT, CCK
31amine439.3SCT, HRH2, HDC
32cyclosporin a43 28 5911.2SCT, IL1RN, LTA, CCK
33endotoxin439.2HRH2, IL1RN, DEFB4A, LTA
34adenylate439.1HRH2, IL1RN, CCK, SST, SCT
35acetylcholine43 49 28 24 1213.0SCT, SST, CCK, LTA, HRH2
36lactate439.0HRH2, IL1RN, LTA, SST
37gaba438.9HDC, CCK, SCT, SST
38cholesterol43 28 24 1211.9LTA, CCK, HRH2, IL1RN, MUC6
39hydrogen43 249.8HDC, SCT, HRH2, IL1RN
40omeprazole43 49 28 24 1212.7HRH2, SST, SCT, HDC, CCK
41dopamine43 28 24 1211.6SCT, HDC, SST, CCK
42glucose438.5DEFB1, SCT, SST, LTA, CCK
43dexamethasone43 49 28 1211.2LTA, IL1RN, DEFB1, CCK, SST, DEFB4A
44glutamate438.2IL1RN, SST, SCT, HDC, LTA, CCK
45pge2437.9SST, SCT, CCK, HDC, HRH2, LTA
46tyrosine437.9CCK, IL1RN, HDC, DEFB4A, LTA, SCT
47rantes437.8SCT, HDC, LTA, DEFB1, DEFB4A, IL1RN
48histamine43 28 249.7SCT, SST, CCK, IL1RN, HRH2, DEFB4A
49calcium43 49 24 1210.1CCK, MUC6, HDC, HRH2, LTA, IL1RN
50retinoic acid43 247.8DEFB1, HDC, DEFB4A, SCT, SST, CCK

GO Terms for genes affiliated with Duodenal Ulcer

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Cellular components related to Duodenal Ulcer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.9LTA, IL1RN, CCK, SST
2Golgi lumenGO:00057968.5DEFB4A, DEFB1, MUC6
3extracellular regionGO:00055767.6CCK, SST, MUC6, SCT, DEFB1, DEFB4A

Biological processes related to Duodenal Ulcer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1visual learningGO:00085429.8HRH2, SCT
2response to nutrientGO:00075849.6LTA, SST
3memoryGO:00076139.5HRH2, IL1RN
4response to drugGO:00424939.3LTA, IL1RN, SST
5G-protein coupled receptor signaling pathwayGO:00071868.9DEFB4A, DEFB1, SST
6immune responseGO:00069558.8HRH2, IL1RN, DEFB1, DEFB4A

Molecular functions related to Duodenal Ulcer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.4CCK, SST, SCT

Products for genes affiliated with Duodenal Ulcer

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Sources for Duodenal Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet