MCID: DDN001
MIFTS: 68

Duodenal Ulcer malady

Gastrointestinal diseases category

Summaries for Duodenal Ulcer

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63Wikipedia, 32MalaCards
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Wikipedia:63 A peptic ulcer, stomach ulcer or gastric ulcer, also known as peptic ulcer disease (PUD), is a distinct... more...

MalaCards: Duodenal Ulcer, also known as stress ulcer, is related to duodenitis and gastric ulcer. An important gene associated with Duodenal Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Immune response Bacterial infections in normal airways and G alpha (q) signalling events. The drugs prazepam and maprotiline and the compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and colon, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Duodenal Ulcer

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

duodenal ulcer 8 10 44 60
stress ulcer 8 44 60
curling ulcer 8 60
acute duodenal ulcer with hemorrhage, with perforation and with obstruction 8
acute duodenal ulcer with hemorrhage and perforation, with obstruction 8
acute duodenal ulcer with perforation, without mention of obstruction 8
chronic duodenal ulcer without hemorrhage and without perforation 8
acute duodenal ulcer with perforation but without obstruction 8
acute duodenal ulcer with perforation, with obstruction 8
acute duodenal ulcer with hemorrhage, with obstruction 8
acute duodenal ulcer with perforation and obstruction 8
acute duodenal ulcer with hemorrhage and perforation 8
acute duodenal ulcer with hemorrhage and obstruction 8
acute duodenal ulcer with perforation 8
acute duodenal ulcer with hemorrhage 8
du - acute + perforation 8
duodenal ulcer disease 44
curling's ulcers 8
stress ulcer nos 8


External Ids:

Disease Ontology8 DOID:1724
MeSH34 D004381
SNOMED-CT56 39755000

Related Diseases for Duodenal Ulcer

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17GeneCards, 18GeneDecks
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Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 255)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis32.1S100A8, GAST
2gastric ulcer31.6GSR, HRH2, CYP2C19, TFF1, GAST, S100A8
3gastritis31.1SCT, S100A8, IL1RN, DEFB4A, GAST, IL8
4pancreatitis30.9CCKAR, CCK, SCT, SST
5esophagitis30.8S100A8, GAST, CYP2C19, HRH2
6gastroduodenitis30.8GAST
7dyspepsia30.8CCK, GAST, HRH2
8zollinger-ellison syndrome30.6GRP, SST, HRH2, SCT, GAST
9peptic ulcer30.6S100A8, SCT, GAST, HDC, SST, CYP2C19
10atrophic gastritis30.5S100A8, GAST, TFF1, SST, IL1RN, SCT
11pancreatic cancer30.5CCK, CCKAR, TFF1, SST, SCT, GAST
12hepatitis30.4LTA, HRH2
13duodenogastric reflux30.4GAST, CCK
14bile reflux30.3TFF1, CCK
15stomach cancer30.2GAST
16ischemia30.2GSR, HRH2
17gastrinoma30.2SST, SCT, GAST, GRP
18gastroesophageal reflux disease30.2CYP2C19, HRH2, GAST, SCT, CCKAR, CCK
19insulinoma30.2GSR, GAST, GRP, SST, SCT
20pneumonia30.1S100A8, DEFB4A, GRP, CXCL1, IL8, HRH2
21diarrhea29.9GAST, SST
22neuroendocrine tumor29.9SST
23cholecystitis29.9CCK
24liver cirrhosis29.9CYP2C19, SCT
25pancreas disease29.9CCK, GAST, CCKAR, SCT
26obesity29.9CCK, CCKAR, GRP
27cushing's syndrome29.9SST
28hypoglycemia29.9SCT, SST, GAST
29hyperparathyroidism29.9SCT, GAST
30steatorrhea29.9SCT, CCK, SST
31diabetes mellitus29.9SCT, GSR, CCKAR, SST, CCK
32wermer syndrome29.9GAST, SST, SCT
33cystic fibrosis29.9IL8, MUC6, DEFB4A, DEFB1, SCT, S100A8
34herpes simplex29.9CCK, TGIF1
35gastric adenocarcinoma29.9S100A8, TFF1, DEFB4A, GRP, HRH2, IL1RN
36sarcoidosis29.9TGIF1, LTA, DEFB4A, GRP, DEFB1, IL1RN
37atherosclerosis29.9IL1RN, IL8, CXCL1
38acute pancreatitis29.9HRH2, CCKAR, CCK, IL8, IL1RN, SST
39meningitis29.9IL8, CXCL1
40islet cell tumor29.9GAST, SST
41hepatocellular carcinoma29.9TGIF1, CYP2C19, GRP, S100A8, SCT
42adenoma29.9MUC6, SST, TFF1, GAST, SCT, S100A8
43duodenal neoplasm29.9SST
44adenocarcinoma29.9GRP, SST, TFF1, CCK, SCT, S100A8
45dumping syndrome29.9SST
46gallbladder disease29.9CCK, CCKAR
47alcoholic pancreatitis29.9CCK, SCT
48duodenal disease10.9
49duodenal obstruction10.5
50polymicrogyria turricephaly hypogenitalism10.3

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to duodenal ulcer

Clinical Features for Duodenal Ulcer

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Drugs & Therapeutics for Duodenal Ulcer

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Duodenal Ulcer

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Anatomical Context for Duodenal Ulcer

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32MalaCards
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MalaCards organs/tissues related to Duodenal Ulcer:

32
Liver, Pancreas, Colon, Testes, Heart, Endothelial, Monocytes, Kidney, T cells, Small intestine

Animal Models for Duodenal Ulcer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Duodenal Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.2TGIF1, CCK, SCT, GAST, TFF1, HDC

Publications for Duodenal Ulcer

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Sources:
50PubMed
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Articles related to Duodenal Ulcer:

(show top 50)    (show all 815)
idTitleAuthorsYear
1
Perforated duodenal ulcer in high risk patients: is percutaneous drainage justified? (22393546)
2012
2
One-stage laparoscopic-assisted resection of gastrojejunocolic fistula after gastrojejunostomy for duodenal ulcer: a case report. (22054096)
2011
3
Duodenal ulcer perforation: a district hospital experience. (21520783)
2011
4
A new PPI, ilaprazole compared with omeprazole in the treatment of duodenal ulcer: a randomized double-blind multicenter trial. (20679904)
2011
5
Why is the coexistence of gastric cancer and duodenal ulcer rare? Examination of factors related to both gastric cancer and duodenal ulcer. (21249411)
2011
6
Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes. (19237517)
2009
7
The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study. (19338650)
2009
8
Staple diets and duodenal ulcer prevalence. (24036556)
2009
9
Genetic features of Helicobacter pylori at patients with duodenal ulcer]. (20469711)
2009
10
Insulinoma-induced hypoglycemia in a patient with nesidiodysplasia after vagomotomy and pyloroplasty for duodenal ulcer. (19322067)
2009
11
Disseminated histoplasmosis presenting with biliary obstruction and duodenal ulcer. (19634648)
2009
12
Bleeding duodenal ulcer with a right upper quadrant mass. (18268056)
2008
13
Comparison of esomeprazole enteric-coated capsules vs esomeprazole magnesium in the treatment of active duodenal ulcer: a randomized, double-blind, controlled study. (18350637)
2008
14
Controversies in the Helicobacter pylori/duodenal ulcer story. (18589464)
2008
15
Perforated duodenal ulcer after laparoscopic gastric bypass. (18443886)
2008
16
Duodenal ulcer-related antigens from Helicobacter pylori: immunoproteome and protein microarray approaches. (17317659)
2007
17
Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese. (16543737)
2006
18
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
19
Th response to Helicobacter pylori differs between patients with gastric ulcer and duodenal ulcer. (16036523)
2005
20
Pathogen evolution in vivo: genome dynamics of two isolates obtained 9 years apart from a duodenal ulcer patient infected with a single Helicobacter pylori strain. (16081988)
2005
21
Gastric and duodenal ulcers--etiopathogenesis, diagnosis and therapy at the milestone of the 20th century]. (15651149)
2004
22
Differentiated approach to surgical treatment of patients with perforated duodenal ulcer. (15279441)
2004
23
Can duodenal ulcer perforation be linked to herpes simplex virus infection? (15106706)
2004
24
Effect of antibacterial therapy and salivary secretion on the efficacy of Helicobacter pylori eradication in duodenal ulcer patients. (15184853)
2004
25
Prevalence of Helicobactor pylori in patients with perforated duodenal ulcer. (15682658)
2004
26
Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer. (12741450)
2003
27
Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pylori infection in patients with bleeding gastro-duodenal ulcer. (14616169)
2003
28
Pathogenesis of H. pylory-associated duodenal ulcer disease. (15146797)
2003
29
Helicobacter pylori infection delays ulcer healing in patients operated on for perforated duodenal ulcer. (11871831)
2002
30
The effectiveness of (IgG-ELISA) serology as an alternative diagnostic method for detecting Helicobacter pylori infection in patients with gastro-intestinal bleeding due to gastro-duodenal ulcer. (12733331)
2002
31
One week regimen of esomeprazole based triple therapy is sufficient for duodenal ulcer healing and Helicobacter pylori eradication in patients with duodenal ulcer disease. (12172417)
2002
32
Short-term changes in Helicobacter pylori gastritis and bulbitis during and after 2 weeks of treatment with omeprazole and amoxicillin in duodenal ulcer patients. (11505330)
2001
33
Low incidence of Helicobacter pylori infection in patients with duodenal ulcer and chronic liver disease. (11346200)
2001
34
Effect of xiaokuiling prescription on the expression of HSP72, HSP B in gastric mucosa of patients with Helicobacter pylori-associated duodenal ulcer. (12539556)
2001
35
Relationship of duodenal ulcer recurrence to gastric metaplasia of the duodenal mucosa and duodenal bulb deformity. (11432308)
2001
36
Novel therapeutic approaches to gastric and duodenal ulcers: an update. (11060758)
2000
37
Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers. (9922305)
1999
38
The prevalence of endoscopic esophagitis in duodenal ulcer patients and symptomatic controls. (17341971)
1998
39
Multiple endocrine neoplasia type 1 presenting as insulinoma, gastrinoma, and postbulbar duodenal ulcers: report of a case. (8555708)
1995
40
Characteristics of teen-age patients with juvenile duodenal ulcer. Relation between inherited hyperpepsinogenemia I and duodenal ulcer. (8430271)
1993
41
Effect of highly selective vagotomy on gastric emptying, gastric acid secretion, and gastrin release: an early postoperative study in duodenal ulcer patients. (7940604)
1993
42
Ultrastructural morphometry of gastric endocrine cells before and after omeprazole. A study in the oxyntic mucosa of duodenal ulcer patients. (2019362)
1991
43
Long-term treatment for gastric and duodenal ulcer. (1983413)
1990
44
Highly selective vagotomy with duodenal dilatation in patients with duodenal ulceration and gastric outlet obstruction. (2276020)
1990
45
Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection. (2327380)
1990
46
Gastric enterochromaffin-like (ECL) cells in hypergastrinaemic duodenal ulcer disease. (2311972)
1990
47
Psychosocial stress and catecholamines: their relationship to ageing, duodenal ulcer, hypochondriasis and hypertension. (3200791)
1988
48
Progression of antral and body gastritis in patients with active and healed duodenal ulcer and duodenitis. (6740215)
1984
49
Measurements of intestinal villi non-specific and ulcer-associated duodenitis-correlation between area of microdissected villus and villus epithelial cell count. (7309898)
1981
50
The physiologic basis of operations for duodenal, gastric, and gastrojejunal ulcer; a review of recent literature. (18136875)
1949

Genetic Variations for Duodenal Ulcer

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Expression for genes affiliated with Duodenal Ulcer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Duodenal Ulcer

Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for genes affiliated with Duodenal Ulcer

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37NCBI BioSystems Database, 53Reactome, 29KEGG
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Pathways related to Duodenal Ulcer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response Bacterial infections in normal airways
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10.4IL8, DEFB4A, IL1RN
2
Hide members
10.3GRP, GAST, CCK, CCKAR
3
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10.3HRH2, SST, CXCL1, IL8, SCT, GRP
4
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10.2SST, HRH2, IL8, CCKAR, CCK, SCT

Compounds for genes affiliated with Duodenal Ulcer

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Duodenal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1pge24410.9GRP, SST
2estrogen4410.9DEFB4A
3glutamate4410.8HDC, SCT, CCK, GAST
4pepsinogen4410.8CCK, GRP, SCT, GAST, HRH2
5indomethacin44 59 28 1113.8GRP, SCT, TFF1, CCKAR
6lafutidine4410.8HRH2, GAST, SST, SCT
7amoxicillin44 49 1112.8S100A8, HRH2, GAST, CYP2C19, IL1RN
8pirenzepine44 28 1112.8GAST, CCK, HRH2, SST, GRP
9ranitidine44 28 11 2413.8HRH2, CCK, CYP2C19, SCT
10loxiglumide4410.8SST, GRP, GAST, SCT, CCK, CCKAR
11clarithromycin44 1111.7IL1RN, GAST, S100A8, HRH2, IL8, CYP2C19
12rantes4410.7S100A8, SCT, HDC, DEFB4A, LTA, CXCL1
13oxyntomodulin44 5911.7CCK, GAST, GRP, SCT, SST
14minigastrin4410.7GAST, SST, GRP, CCK
15caerulein4410.7CCK, CCKAR, SCT, GRP
16atropine44 28 1112.7GAST, SCT, GRP, CCKAR, HRH2, SST
17endotoxin4410.7S100A8, CXCL1, DEFB4A, HRH2
18cycloheximide4410.7TFF1, LTA
19bethanechol44 28 1112.7SST, GRP, GAST, CCK
20pantoprazole44 49 11 2413.7HRH2, GAST, CYP2C19, SST
21octreotide44 59 28 1113.7CCKAR, SST, GRP, GAST, SCT, CCK
22omeprazole44 28 49 11 2414.7CCKAR, CCK, S100A8, SCT, GAST, HDC
23epinephrine44 11 2412.7IL1RN, SCT, HRH2, GRP, SST, CXCL1
24gaba4410.7SCT, HDC, CCK, GRP, GAST, CCKAR
25lansoprazole49 44 11 2413.7IL1RN, CYP2C19, GAST, HRH2
26dopamine44 28 11 2413.6HDC, GRP, GAST, CYP2C19, TGIF1, CCK
27dexamethasone44 49 28 1113.6DEFB1, DEFB4A, GRP, LTA, CYP2C19, CXCL1
28cyclic amp44 2411.6HDC, GRP, HRH2, CCKAR, TGIF1, SCT
29acetylcholine44 49 28 11 2414.6SST, CCK, SCT, GAST, GRP, LTA
30tetrodotoxin44 59 2812.6HRH2, SCT, CCKAR, CCK, GRP
31lactate4410.6TGIF1, HRH2, IL8, LTA, GSR, IL1RN
32histamine44 28 2412.6SCT, GAST, HRH2, CCK, S100A8, HDC
33adenylate4410.6SST, GAST, CCK, SCT, CXCL1, GSR
34testosterone44 59 11 2413.6IL1RN, GAST, SCT, CCK, TGIF1, SST
35propranolol44 28 49 11 2414.6GAST, SST, SCT, GRP, CYP2C19
36dtpa4410.6CCK, GRP, SST, GAST
37lorglumide44 2811.6GAST, CCK, CCKAR
38vegf4410.5TGIF1, CXCL1, LTA, SST, GRP, TFF1
39l3652604410.5CCK, CCKAR, GAST
40retinoic acid44 2411.5TFF1, HDC, DEFB1, DEFB4A, GRP, SST
41acth4410.5SCT, GRP, SST, IL1RN, CCK, GAST
42ym0224410.5GAST, CCK, CCKAR
43progesterone44 59 28 11 2414.5IL1RN, TGIF1, CXCL1, CYP2C19, MUC6, LTA
44tyrosine4410.5S100A8, CCK, LTA, SCT, HDC, CYP2C19
45calcium44 49 11 2413.5CCKAR, CCK, S100A8, SCT, GAST, MUC6
46devazepide44 28 5912.4CCK, CCKAR, GAST
47genistein44 28 59 2 11 2415.3IL8, SST, TGIF1, GRP, TFF1, GSR
48cholesterol44 28 11 2413.3HRH2, CCKAR, IL1RN, MUC6, LTA, TGIF1
49cyclosporin a44 28 5912.2CCK, LTA, SCT, IL8, IL1RN, CXCL1
50taurodeoxycholate4410.1SCT, SST, CCK

GO Terms for genes affiliated with Duodenal Ulcer

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16Gene Ontology
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Cellular components related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.4MUC6, DEFB4A, DEFB1
2extracellular regionGO:00557610.1IL8, CCK, S100A8, SCT, GAST, DEFB1
3extracellular spaceGO:0056159.9CCK, S100A8, TFF1, GRP, SST, LTA

Biological processes related to Duodenal Ulcer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.5CCKAR, TFF1, SST
2G-protein coupled receptor signaling pathwayGO:00718610.5IL8, CXCL1, SST, DEFB4A, DEFB1, GAST
3immune responseGO:00695510.5DEFB1, DEFB4A, CXCL1, IL1RN, IL8, HRH2
4maintenance of gastrointestinal epitheliumGO:03027710.5MUC6, TFF1
5negative regulation of cell proliferationGO:00828510.5TGIF1, IL8, CXCL1, SST, TFF1
6acute inflammatory responseGO:00252610.4DEFB1, S100A8
7response to nutrientGO:00758410.4LTA, SST, CCKAR
8signal transductionGO:00716510.2CCK, GAST, GRP, LTA, CXCL1, IL8
9response to drugGO:04249310.1TGIF1, IL1RN, LTA, SST

Molecular functions related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.4SST, GAST, SCT, CCK

Products for genes affiliated with Duodenal Ulcer

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Sources for Duodenal Ulcer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet