MCID: DDN001
MIFTS: 61

Duodenal Ulcer malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Duodenal Ulcer

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Wikipedia:64 A peptic ulcer is a distinct breach in the mucosal lining of the stomach (gastric ulcer) or the first... more...

MalaCards based summary: Duodenal Ulcer, also known as stress ulcer, is related to gastritis and dyspepsia. An important gene associated with Duodenal Ulcer is HRH2 (histamine receptor H2), and among its related pathways are Defensins and Peptide ligand-binding receptors. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Duodenal Ulcer

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Sources:
9Disease Ontology, 11DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 34MeSH, 26ICD10
See all sources

Duodenal Ulcer, Aliases & Descriptions:

Name: Duodenal Ulcer 9 11 44 61
Stress Ulcer 9 44 61
Duodenal Ulcer Disease 44 61
Curling's Ulcers 9 61
 
Curling Ulcer 9 61
Du - Acute + Perforation 9
Stress Ulcer Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology9 DOID:1724
MeSH34 D004381
SNOMED-CT56 39755000
ICD1026 K26

Related Diseases for Duodenal Ulcer

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Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.4IL1RN, SCT, DEFB4A
2dyspepsia31.3HRH2, CCK
3pancreatitis31.3CCK, SST, SCT
4duodenogastric reflux31.2CCK
5zollinger-ellison syndrome31.0SCT, SST, HRH2
6atrophic gastritis30.9SCT, SST, IL1RN
7pancreatic cancer30.8CCK, SST, SCT
8dumping syndrome30.7SST
9gastrinoma30.7SCT, SST
10gastroesophageal reflux disease30.6HRH2, CCK, SCT
11alcoholic pancreatitis30.6CCK, SCT
12pancreas disease30.5CCK, SCT
13wermer syndrome30.5SST, SCT
14steatorrhea30.3SCT, SST, CCK
15pneumonia30.2HRH2, DEFB1, DEFB4A
16periodontal disease30.1DEFB4A, DEFB1, IL1RN
17nephritis30.0LTA, IL1RN
18diabetes mellitus30.0CCK, SST, SCT
19acute pancreatitis29.9SCT, SST, CCK, IL1RN, HRH2
20adenocarcinoma29.8SCT, MUC6, SST, CCK
21neuroendocrine tumor29.8CCK, SST, SCT, HDC
22periodontitis29.8LTA, IL1RN, DEFB1, DEFB4A
23sarcoidosis29.8LTA, IL1RN, DEFB1, DEFB4A
24stomach cancer29.7HDC, MUC6, CCK, IL1RN, HRH2
25cystic fibrosis29.7DEFB4A, DEFB1, SCT, MUC6
26peptic ulcer disease29.6HDC, SCT, SST, CCK, HRH2
27duodenitis11.5
28gastric cancer10.7
29esophagitis10.6
30gastroduodenitis10.6
31h. pylori infection10.6
32gastric ulcer10.5
33blindness10.5
34neuhauser daly magnelli syndrome10.5
35angiodysplasia10.5SST
36gastric outlet obstruction10.4
37oral candidiasis10.4DEFB4A
38hyperinsulinemic hypoglycemia10.3SCT, SST
39exocrine pancreatic insufficiency10.3SCT, CCK
40hepatitis10.3
41hiatus hernia10.3
42pneumothorax10.3
43duodenal ulcer due to antral g-cell hyperfunction10.3
44candidiasis10.3DEFB4A
45vipoma10.3SST, SCT
46gastrointestinal system disease10.3CCK, SCT
47glucose intolerance10.3HRH2, CCK
48cholelithiasis10.3SST, CCK
49short bowel syndrome10.3CCK, SST
50peptic esophagitis10.3

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to duodenal ulcer

Symptoms for Duodenal Ulcer

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Drugs & Therapeutics for Duodenal Ulcer

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Genetic Tests for Duodenal Ulcer

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Anatomical Context for Duodenal Ulcer

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MalaCards organs/tissues related to Duodenal Ulcer:

32
Small intestine, Liver, Colon, Pancreas, Testes, Heart, Endothelial, Neutrophil, Kidney, Monocytes, T cells

Animal Models for Duodenal Ulcer or affiliated genes

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MGI Mouse Phenotypes related to Duodenal Ulcer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8LTA, HRH2, CCK, SST, SCT, HDC
2MP:00053767.1LTA, HDC, SCT, SST, CCK, IL1RN

Publications for Duodenal Ulcer

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Articles related to Duodenal Ulcer:

(show top 50)    (show all 741)
idTitleAuthorsYear
1
Closure of a perforated duodenal ulcer by over-the-scope clip. (25028271)
2014
2
Helicobacter pylori from gastric cancer and duodenal ulcer show same phylogeographic origin in the Andean region in Colombia. (25121764)
2014
3
Acute mesenteric ischemia and duodenal ulcer perforation: a unique double pathology. (23110681)
2012
4
Fatal acute pancreatitis following sclerosis of a bleeding duodenal ulcer complicated by an intramural duodenal hematoma. (23368652)
2012
5
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. (21220246)
2011
6
Antiulcer activity of Andrographis paniculata (Burm.f.) wall. against cysteamine-induced duodenal ulcer in rats. (21800503)
2011
7
Pyloric Pseudodiverticulum: A rare incidental finding during the repair of perforated duodenal ulcer. (23133235)
2010
8
Recurrent duodenal ulcer due to nonsteroidal anti-inflammatories following the suspension of antiulcer medication. (19938884)
2009
9
Duodenal ulcer due to yttrium microspheres used for selective internal radiation therapy of hepatocellular cancer. (18950763)
2009
10
Bleeding duodenal ulcer with a right upper quadrant mass. (18268056)
2008
11
Interleukin-1beta gene polymorphism as a predictor of eradication treatment efficacy in gastric and duodenal ulcer associated with Helicobacter pylori]. (19145908)
2008
12
Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (18809506)
2008
13
Pattern of change in the frequency of Helicobacter pylori with perforated duodenal ulcer. (19999201)
2008
14
Changes in reducing power profile of gastric juice in patients with active duodenal ulcer. (16095868)
2005
15
Deformity of duodenal bulb, gastric metaplasia of duodenal regenerating mucosa and recurrence of duodenal ulcer: a correlated study. (15793868)
2005
16
Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries. (15866209)
2005
17
Antral and duodenal disaccharidases in patients of duodenal ulcer and non-ulcer dyspepsia. (23105518)
2005
18
Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: study by 24-h pH monitoring in patients with gastric or duodenal ulcer. (15870971)
2005
19
Surgical management of perforated duodenal ulcer: the changing scene. (15816264)
2004
20
Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infected duodenal ulcer patients. (12522049)
2003
21
Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy. (14512101)
2003
22
Effect of Helicobacter pylori eradicated therapy on water gastric emptying in patients with active duodenal ulcer. (14535981)
2003
23
Association between Helicobacter pylori virulence and duodenal ulcer disease in patients from Hong Kong in China]. (12697114)
2003
24
The sixth decision regarding perforated duodenal ulcer. (12500837)
2002
25
Relationship between the birth cohort pattern of Helicobacter pylori infection and the epidemiology of duodenal ulcer. (12145391)
2002
26
Detection of Helicobacter pylori-associated asymptomatic duodenal ulcer in a boy. (11982907)
2002
27
Eradication of Helicobacter pylori in duodenal ulcer disease tetracycline & furazolidone vs. metronidazole & amoxicillin in omeprazole based triple therapy. (11889461)
2002
28
14C urea breath test does not predict density of Helicobacter pylori in duodenal ulcer disease. (11558321)
2001
29
Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer? (11421880)
2001
30
Immunogenetic factors of predisposition to duodenal ulcer in Caucasian population of western Siberia. (11507979)
2001
31
Helicobacter pylori infection in patients with perforated chronic duodenal ulcer. (11676339)
2001
32
Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. (10930902)
2000
33
Ultrastructural study of the gastric mucosa and Helicobacter pylori in duodenal ulcer patients. (11500709)
2000
34
Five-day triple therapy in Helicobacter pylori-positive duodenal ulcer: an eighteen-month follow-up. (10993428)
2000
35
Smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients in Taiwan. (10548360)
1999
36
Effect of chronic duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF receptor expression in humans. (9881512)
1998
37
Effect of curing Helicobacter pylori infection on intragastric acidity during treatment with ranitidine in patients with duodenal ulcer. (9274468)
1997
38
Presence of the cagA gene in the majority of Helicobacter pylori strains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis. (9398887)
1996
39
Helicobacter pylori and duodenal ulcer: evidence for a histamine pathways-involving link. (8931414)
1996
40
Immunogenetic analysis of the human leukocyte antigen DQA1 locus in patients with duodenal ulcer or chronic atrophic gastritis harbouring Helicobacter pylori. (8574742)
1995
41
Prospective randomized study comparing three surgical techniques for the treatment of gastric outlet obstruction secondary to duodenal ulcer. (8101050)
1993
42
pH-dependent secretion of gastrin in duodenal ulcer disease: effect of suppressing Helicobacter pylori. (1459351)
1992
43
Patients with duodenitis have gastric secretory and motor functions like those of duodenal ulcer patients: results of a short-term treatment with ranitidine. (2066545)
1991
44
Ceruloplasmin activity in blood serum in stomach and duodenal ulcers]. (1966196)
1990
45
Long-term treatment for gastric and duodenal ulcer. (1983413)
1990
46
Oxyntic mucosa histology in omeprazole-treated patients suffering from duodenal ulcer or Zollinger-Ellison syndrome. (3792669)
1986
47
Use of a provocation test for objective assessment of dumping syndrome in patients undergoing surgery for duodenal ulcer. (7468560)
1980
48
Bleeding duodenal ulcer as a complication of treatment of status asthmaticus with adrenal corticosteroids. (6967706)
1980
49
Gastritis, duodenitis, and bleeding duodenal ulcer following mefenamic acid therapy. (949194)
1976
50
A five-to ten-year follow-up study of the Billroth I and Billroth II (polya) operations for duodenal, gastric and gastrojejunal ulcer and gastroenterostomy with vagotomy in the treatment of duodenal ulcer. (13480410)
1957

Variations for Duodenal Ulcer

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Expression for genes affiliated with Duodenal Ulcer

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Expression patterns in normal tissues for genes affiliated with Duodenal Ulcer

Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for genes affiliated with Duodenal Ulcer

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Compounds for genes affiliated with Duodenal Ulcer

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Compounds related to Duodenal Ulcer according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1epft4410.2CCK, SCT
2l-bpa4410.1SCT, CCK
3caerulein4410.1SCT, CCK
4pancreozymin4410.1SCT, CCK
5cerulein4410.0CCK, SCT
6minigastrin4410.0CCK, SST
7enprostil44 2911.0HRH2, SST
8vapreotide44 29 1211.9SST, CCK
9pepsinogen449.9SCT, CCK, HRH2
10ranitidine44 29 25 1212.9CCK, SCT, HRH2
11lafutidine449.9SST, SCT, HRH2
12alosetron44 1210.9SST, CCK
13tetrodotoxin44 60 2911.8HRH2, SCT, CCK
14taurodeoxycholate449.8SCT, CCK, SST
15bicarbonate449.8HRH2, CCK, SCT
16loxiglumide449.8CCK, SCT, SST
17pirenzepine44 29 1211.8HRH2, SST, CCK
18benzodiazepines449.8CCK, HRH2
19oxyntomodulin44 6010.8CCK, SST, SCT
20octreotide44 60 29 1212.7SST, SCT, CCK
21c-peptide449.7CCK, SCT, SST
22triprolidine44 29 1211.7HDC, HRH2
23glipizide44 50 1211.7SST, HRH2
24atropine44 29 1211.5HRH2, SCT, SST, CCK
25epinephrine44 25 1211.5SCT, SST, HRH2, IL1RN
26lipoteichoic acid449.4IL1RN, LTA, DEFB4A
27acth449.4IL1RN, SCT, SST, CCK
28bethanechol44 29 1211.4SST, CCK
29norepinephrine44 25 1211.4CCK, IL1RN, SST, SCT
30forskolin44 50 1211.3HRH2, LTA, SCT, CCK
31amine449.3SCT, HRH2, HDC
32cyclosporin a44 29 6011.2SCT, IL1RN, LTA, CCK
33endotoxin449.2HRH2, IL1RN, DEFB4A, LTA
34adenylate449.1HRH2, IL1RN, CCK, SST, SCT
35acetylcholine44 50 29 25 1213.0SCT, SST, CCK, LTA, HRH2
36lactate449.0HRH2, IL1RN, LTA, SST
37gaba448.9HDC, CCK, SCT, SST
38cholesterol44 29 25 1211.9LTA, CCK, HRH2, IL1RN, MUC6
39hydrogen44 259.8HDC, SCT, HRH2, IL1RN
40omeprazole44 50 29 25 1212.7HRH2, SST, SCT, HDC, CCK
41dopamine44 29 25 1211.6SCT, HDC, SST, CCK
42glucose448.5DEFB1, SCT, SST, LTA, CCK
43dexamethasone44 50 29 1211.2LTA, IL1RN, DEFB1, CCK, SST, DEFB4A
44glutamate448.2IL1RN, SST, SCT, HDC, LTA, CCK
45pge2447.9SST, SCT, CCK, HDC, HRH2, LTA
46tyrosine447.9CCK, IL1RN, HDC, DEFB4A, LTA, SCT
47rantes447.8SCT, HDC, LTA, DEFB1, DEFB4A, IL1RN
48histamine44 29 259.7SCT, SST, CCK, IL1RN, HRH2, DEFB4A
49calcium44 50 25 1210.1CCK, MUC6, HDC, HRH2, LTA, IL1RN
50retinoic acid44 257.8DEFB1, HDC, DEFB4A, SCT, SST, CCK

GO Terms for genes affiliated with Duodenal Ulcer

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Cellular components related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.9LTA, IL1RN, CCK, SST
2Golgi lumenGO:0057968.5DEFB4A, DEFB1, MUC6
3extracellular regionGO:0055767.6CCK, SST, MUC6, SCT, DEFB1, DEFB4A

Biological processes related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual learningGO:0085429.8HRH2, SCT
2response to nutrientGO:0075849.6LTA, SST
3memoryGO:0076139.5HRH2, IL1RN
4response to drugGO:0424939.3LTA, IL1RN, SST
5G-protein coupled receptor signaling pathwayGO:0071868.9DEFB4A, DEFB1, SST
6immune responseGO:0069558.8HRH2, IL1RN, DEFB1, DEFB4A

Molecular functions related to Duodenal Ulcer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4CCK, SST, SCT

Products for genes affiliated with Duodenal Ulcer

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Sources for Duodenal Ulcer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet