MCID: DDN001
MIFTS: 53

Duodenal Ulcer

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Duodenal Ulcer

MalaCards integrated aliases for Duodenal Ulcer:

Name: Duodenal Ulcer 12 51 41 14 69
Stress Ulcer 12 51 69
Curling Ulcer 12 69
Stress Ulcer of Stomach 69
Duodenal Ulcer Disease 51
Curling's Ulcers 12

Classifications:



Summaries for Duodenal Ulcer

MalaCards based summary : Duodenal Ulcer, also known as stress ulcer, is related to duodenitis and pancreatitis. An important gene associated with Duodenal Ulcer is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Allograft rejection and IL-17 Family Signaling Pathways. The drugs Amoxicillin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and colon.

Related Diseases for Duodenal Ulcer

Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 duodenitis 31.8 GAST INS
2 pancreatitis 30.5 CCK SCT SST
3 gastroenteritis 30.3 CXCL8 IL1B TNF
4 esophagitis 30.1 CXCL8 CYP2C19 HRH2 IL1B
5 appendicitis 30.0 CXCL8 IL1B TNF
6 peritonitis 30.0 CXCL8 IL1B TNF
7 gastritis 29.9 CXCL8 GAST HRH2 IL1B IL1RN S100A8
8 haemophilus influenzae 29.9 CXCL8 IL1B TNF
9 neuroendocrine tumor 29.8 GAST GRP SST
10 lymphadenitis 29.8 CXCL8 IL1B TNF
11 intestinal disease 29.8 CXCL8 IL1B TNF
12 meningitis 29.8 CXCL8 IL1B TNF
13 periodontitis 29.8 CXCL8 IL1B TNF
14 duodenogastric reflux 29.8 CCK GAST SCT SST
15 zollinger-ellison syndrome 29.7 GAST GRP HRH2 SCT SST
16 diarrhea 29.6 CCK GAST SST TNF
17 steatorrhea 29.6 CCK SCT SST
18 dyspepsia 29.5 CCK CXCL8 CYP2C19 HRH2 SST
19 peptic esophagitis 29.5 CXCL8 CYP2C19 HRH2 IL1B
20 acute pancreatitis 29.5 CCK CXCL8 SCT SST
21 periodontal disease 29.5 CXCL8 IL1B IL1RN TNF
22 peptic ulcer disease 29.5 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
23 islet cell tumor 29.4 GAST INS SST
24 helicobacter pylori infection 29.4 CXCL8 CYP2C19 GAST IL1B IL1RN S100A8
25 burns 29.4 IL1B INS TNF
26 atrophic gastritis 29.3 CXCL8 GAST IL1B IL1RN S100A8 TNF
27 gastrinoma 29.3 GAST INS SCT SST
28 gastric ulcer 29.3 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
29 insulinoma 29.2 INS SCT SST
30 duodenal gastrinoma 29.2 CCK GAST GRP SCT
31 gastroesophageal reflux 29.2 CCK CXCL8 CYP2C19 HRH2 IL1B
32 dumping syndrome 29.1 INS SCT SST
33 pancreatic cancer 29.0 CCK CXCL8 GAST GRP SCT SST
34 arthritis 28.9 CXCL8 IL1B IL1RN LTA TNF
35 multiple endocrine neoplasia, type i 28.8 GAST INS SCT SST
36 pancreas disease 28.4 CCK INS SCT SST TNF
37 tremor, nystagmus, and duodenal ulcer 12.2
38 duodenal ulcer due to antral g-cell hyperfunction 12.2
39 duodenal ulcer, hyperpepsinogenemic i 12.1
40 chronic erosive gastritis 11.2
41 neuhauser daly magnelli syndrome 11.1
42 xanthinuria, type ii 11.0
43 gastrointestinal neuroendocrine benign tumor 10.6 GAST SST
44 gastric neuroendocrine neoplasm 10.6 GAST SST
45 pylorospasm 10.6 GAST SST
46 polyposis, gastric 10.6 IL1B TNF
47 systemic onset juvenile idiopathic arthritis 10.5 IL1B TNF
48 staphylococcal toxic shock syndrome 10.5 IL1B TNF
49 kashin-beck disease 10.5 IL1B TNF
50 recurrent corneal erosion 10.5 CXCL8 IL1B

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to Duodenal Ulcer

Symptoms & Phenotypes for Duodenal Ulcer

Drugs & Therapeutics for Duodenal Ulcer

Drugs for Duodenal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 106)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
2
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
3
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
4
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3 117976-89-3 5029
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
6
Pantoprazole Approved Phase 4,Phase 3,Phase 1 102625-70-7 4679
7
Dexlansoprazole Approved, Investigational Phase 4,Phase 3 138530-94-6, 103577-45-3 9578005
8
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
9
Acetaminophen Approved Phase 4 103-90-2 1983
10
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
11
Potassium Citrate Approved, Investigational, Vet_approved Phase 4,Phase 3
12
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 9579578 4594
13
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
14
Loxoprofen Approved, Investigational Phase 4 68767-14-6, 80382-23-6 3965
15
Ranitidine Approved Phase 4,Phase 3 66357-59-3, 66357-35-5 3001055
16
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
17
Furazolidone Approved, Investigational, Vet_approved Phase 4 67-45-8 5323714 3435
18
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
19 Antacids Phase 4,Phase 3,Phase 2,Phase 1
20 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
21 Anti-Infective Agents Phase 4,Phase 2,Phase 3
22 Antiparasitic Agents Phase 4,Phase 2,Phase 3
23 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
24 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
26 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
27 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Proton pump inhibitors Phase 4,Phase 2,Phase 3,Phase 1
29 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
30 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
33 Antipyretics Phase 4,Phase 3,Phase 2,Phase 1
34 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
36 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
39 Antibiotics, Antitubercular Phase 4
40
Bismuth Phase 4,Phase 3 7440-69-9 105143 16682734
41 diuretics Phase 4,Phase 3,Phase 2
42 Expectorants Phase 4,Phase 3
43 Natriuretic Agents Phase 4,Phase 3,Phase 2
44 Respiratory System Agents Phase 4,Phase 3
45 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
46 Anticoagulants Phase 4
47 Ranitidine bismuth citrate Phase 4,Phase 3
48 Anti-Infective Agents, Local Phase 4
49 Antimalarials Phase 4
50 Calcium, Dietary Phase 4

Interventional clinical trials:

(show top 50) (show all 106)

# Name Status NCT ID Phase Drugs
1 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
2 The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers Completed NCT00594867 Phase 4 Acetaminophen - 4 grams per day + Placebo;Aspirin - 325 mg per day + Placebo;Acetaminophen 4 gram per day + Aspirin 325 mg per day
3 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection Completed NCT00854451 Phase 4 omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin
4 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4 omeprazole;omeprazole
5 Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection Completed NCT02835560 Phase 4 Ilaprazole antisecretory drug of each quadruple therapy the Ilaprazole -based quadruple therapy;Esoprazole antisecretory drug of each quadruple therapy Esoprazole-based quadruple therapy
6 A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn Completed NCT00237367 Phase 4 rabeprazole and pantoprazole
7 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
8 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
9 Study Of Celecoxib In Healthy Subjects Completed NCT00994461 Phase 4 Celecoxib;Loxoprofen;Placebo
10 Helicobacter Eradication Aspirin Trial Active, not recruiting NCT01506986 Phase 4 Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg;Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
11 The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers Not yet recruiting NCT03342456 Phase 4 Doxycycline Hyclate Enteric-Coated Capsules;Amoxicillin Capsules;Ilaprazole Enteric-Coated Tablets;Furazolidone Tablets;Potassium Citrate Tablets
12 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
13 Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control Withdrawn NCT00713947 Phase 4 during one week for the active treatments;Pantoprazole;Placebo Formula 515
14 Misoprostol for Small Bowel Ulcers and Obscure Bleeding Due to Aspirin or Nonsteroidal Antiinflammatory Drugs Unknown status NCT02202967 Phase 3 Misoprostol;Placebo
15 Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection Unknown status NCT00197418 Phase 2, Phase 3 rabeprazole, amoxicillin, clarithromycin, metronidazole
16 Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori Unknown status NCT00149084 Phase 3 Lansoprazole, clarithromycin, amoxicillin
17 Efficacy and Safety of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Duodenal Ulcer Completed NCT01452724 Phase 3 TAK-438;Placebo;Lansoprazole;Placebo
18 Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study) Completed NCT01397448 Phase 2, Phase 3 E3810;E3810;Teprenone
19 Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients Completed NCT02847455 Phase 2, Phase 3 5 mg ilaprazole;10 mg ilaprazole;10 mg Rabeprazole
20 Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin Completed NCT01452763 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
21 Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID) Completed NCT01452750 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
22 Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study) Completed NCT01398410 Phase 2, Phase 3 Rabeprazole;Rabeprazole
23 Efficacy and Safety of Lansoprazole on Gastric and Duodenal Ulcers in Patients Taking Nonsteroidal Anti-Inflammatory Drugs Completed NCT00787254 Phase 3 Lansoprazole;Gefarnate
24 Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3) Completed NCT00952978 Phase 3 10 mg ilaprazole;20 mg omeprazole
25 Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID Completed NCT00542789 Phase 3 Esomeprazole;Placebo
26 Comparative Efficacy & Safety Study of D961H Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With Low-dose Aspirin Completed NCT01069939 Phase 3 Esomeprazole;Placebo
27 Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin Completed NCT01456247 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
28 Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID) Completed NCT01456260 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
29 A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Low-Dose Aspirin Therapy Completed NCT01568398 Phase 3 TAK-438
30 A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Non-Steroid Anti-Inflammatory Drug (NSAID) Therapy Completed NCT01568385 Phase 3 TAK-438
31 Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced Ulcer Completed NCT00595517 Phase 3 Esomeprazole 20 mg
32 Cardio-cerebrovascular Disease and Aspirin Ulcer Relapse Evaluation Completed NCT01051388 Phase 3 Low-dose PPI (Rabeprazole sodium);High-dose PPI (Rabeprazole sodium);Non-PPI (Gefarnate)
33 ASTERIX: Low Dose ASA and Nexium Completed NCT00251966 Phase 3 Esomeprazole
34 Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA) Completed NCT00441727 Phase 3 Esomeprazole 40 mg;Esomeprazole 20 mg;Placebo
35 Efficacy/Safety Study as H. Pylori Eradication of Triple Therapy for 7 Days Treatment Completed NCT02084420 Phase 3 Ilaprazole;Pantoprazole
36 A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases Completed NCT02153398 Phase 3 D961H sachet 10 mg;D961H capsule 10mg;D961H capsule 20 mg
37 Ulcer Prevention II Completed NCT00629928 Phase 3 Esomeprazole;Esomeprazole;Placebo
38 Safety, Tolerability and Efficacy Study With a Fixed-Dose Combination (FDC) Ketoprofen Plus Omeprazole Completed NCT00971581 Phase 3 FDC KETOPROFEN+OMEPRAZOLE
39 A Study of Rabeprazole for Prevention of Non Steroidal Anti-inflammatory Drug -Associated Gastroduodenal Injury Completed NCT01140828 Phase 3 Rabeprazole;Rabeprazole Placebo
40 Efficacy of TAK-438, Amoxicillin and Clarithromycin in the First Line Eradication of H. Pylori Completed NCT01505127 Phase 3 TAK-438;Lansoprazole;Amoxicillin;Clarithromycin
41 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers. Completed NCT00367211 Phase 3 PN 200 tablets (500 mg naproxen and 20 mg omeprazole);Naproxen 500 mg tablets (PN 200 minus omeprazole)
42 Phase III General Clinical Study of NPO-11 in Patients Undergoing Gastric Endoscopy Completed NCT00745459 Phase 3 NPO-11
43 Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers Completed NCT00450658 Phase 3 HZT-501;Ibuprofen
44 Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment Completed NCT00450216 Phase 3 Ibuprofen/famotidine;Ibuprofen
45 Helicobacter Pylori Eradication With a New Sequential Treatment Completed NCT00132171 Phase 3 Sequential therapy
46 A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00961350 Phase 3 PA32540;EC Aspirin 325
47 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00960869 Phase 3 PA32540;EC-Aspirin 325 mg
48 A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin Completed NCT00175032 Phase 3 Lansoprazole and naproxen and aspirin;Celecoxib and aspirin
49 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT01129011 Phase 3 PN400 (VIMOVO);Naproxen
50 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT00527787 Phase 3 PN400 (VIMOVO);Naproxen

Search NIH Clinical Center for Duodenal Ulcer

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: duodenal ulcer

Genetic Tests for Duodenal Ulcer

Anatomical Context for Duodenal Ulcer

MalaCards organs/tissues related to Duodenal Ulcer:

38
Testes, Liver, Colon, Pancreas, Heart, Endothelial, Neutrophil

Publications for Duodenal Ulcer

Articles related to Duodenal Ulcer:

(show top 50) (show all 845)
# Title Authors Year
1
The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding. ( 29342468 )
2018
2
Application of over-the-scope clip for massive duodenal ulcer bleeding in a 4-year-old boy weighing 7.8 kg. ( 29169193 )
2018
3
Duodenal Ulcer - IgA Vasculitis. ( 28202872 )
2017
4
Perforated Duodenal Ulcer. ( 28248764 )
2017
5
Adapted ERAS Pathway vs. Standard Care in Patients with Perforated Duodenal Ulcer-a Randomized Controlled Trial. ( 28653239 )
2017
6
Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer. ( 28465717 )
2017
7
Successful Endoscopic Treatment of Bouveret Syndrome in a Patient with Choledochoduodenal Fistula Complicating Duodenal Ulcer. ( 28758036 )
2017
8
EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER. ( 28977115 )
2017
9
Emphysematous pancreatitis associated with penetrating duodenal ulcer. ( 29358874 )
2017
10
ExposAc: Different Faces of a Bleeding Giant Duodenal Ulcer. ( 28871345 )
2017
11
Endoscopic View of Gastroduodenal Artery Coils at the Base of Duodenal Ulcer in Case of Recurrent Massive Upper Gastrointestinal Bleed. ( 28507835 )
2017
12
Cytomegalovirus Associated Duodenal Ulcer and Duodenitis in a Malnourished Pediatric Patient. ( 29119032 )
2017
13
A Rare Case of Pancreas Divisum Accompanied by Acute Pancreatitis Following Endoscopic Hemostasis for Duodenal Ulcer Bleeding. ( 28449428 )
2017
14
Declining prevalence of duodenal ulcer at endoscopy in Ile-Ife, Nigeria. ( 28875881 )
2017
15
Effectiveness of arterial embolization in recurrent bleeding due to duodenal ulcer during postoperative cardiac surgery. ( 28372451 )
2017
16
VacA and CagA Status as Biomarker of Two Opposite End Outcomes of Helicobacter pylori Infection (Gastric Cancer and Duodenal Ulcer) in a Moroccan Population. ( 28125638 )
2017
17
The Relationship of Mean Platelet Volume/Platelet Distribution Width and Duodenal Ulcer Perforation. ( 28442518 )
2017
18
A case of an intractable duodenal ulcer associated with a pancreatic arteriovenous malformation. ( 28484196 )
2017
19
Massive Gastrointestinal Bleeding from Neonatal Duodenal Ulcer. ( 28975747 )
2017
20
A Curious Case of Intestinal Diaphragm Disease Unmasked by Perforation of a Duodenal Ulcer. ( 28523070 )
2017
21
Closure of duodenal ulcer perforation using a novel endoloop device with a single-channel gastroscope after failed laparoscopic repair. ( 28068696 )
2017
22
Helicobacter pylori and gastric or duodenal ulcer. ( 26942258 )
2016
23
A Non-invasive 24 Hours Stabilization of Duodenal Ulcer Perforation by a Combination Regimen. ( 28083452 )
2016
24
Weight loss and decubitus duodenal ulcer in Parkinson's disease treated with levodopa-carbidopa intestinal gel infusion. ( 27614656 )
2016
25
An Unusual Cause of Duodenal Ulcer Bleeding. ( 27091725 )
2016
26
Successful Conservative Treatment of a Cholecystoduodenal Fistula Caused by a Cytomegalovirus-associated Duodenal Ulcer. ( 27629956 )
2016
27
A refractory duodenal ulcer with a biliary-duodenal fistula following the administration of bevacizumab. ( 27383109 )
2016
28
Duodenal Ulcer Induced by Hem-o-Lok clip after Reduced Port Laparoscopic Cholecystectomy. ( 27014759 )
2016
29
Successful Endoscopic Management of Non-Healing Perforated Duodenal Ulcer with Polyglycolic Acid Sheet and Fibrin Glue. ( 28119948 )
2016
30
Pyopneumothorax and peritonitis due to perforated duodenal ulcer and associated pleuroperitoneal communication. ( 27372035 )
2016
31
The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report. ( 27348901 )
2016
32
Sequential versus concomitant therapy for eradication of Helicobacter Pylori in patients with perforated duodenal ulcer: A randomized trial. ( 27488326 )
2016
33
Association of Endoscopic Esophageal Variceal Ligation with Duodenal Ulcer. ( 27097695 )
2016
34
History of a penetrating duodenal ulcer as a cause of acute necrotizing pancreatitis. ( 27305186 )
2016
35
The Effect of Helicobacter pylori Eradication on the Gastrointestinal Microbiota in Patients with Duodenal Ulcer. ( 27308643 )
2016
36
A life-threatening duodenal ulcer hemorrhage due to previously unknown primary hyperparathyroidism. ( 27616071 )
2016
37
Laparoscopic surgical technique for perforated duodenal ulcer. ( 26972898 )
2016
38
Successful treatment of a perforated duodenal ulcer with polyglycolic acid sheets. ( 27492713 )
2016
39
Cytomegalovirus-infected duodenal ulcer with severe recurrent bleeding. ( 26852085 )
2016
40
Peritonitis Following Duodenal Ulcer Perforation in a Newborn: A Case Report. ( 28050434 )
2016
41
Modeling the cost-effectiveness of ilaprazole versus omeprazole for the treatment of newly diagnosed duodenal ulcer patients in China. ( 27223846 )
2016
42
Perforated Duodenal Ulcer. ( 26928104 )
2016
43
Helicobacter pylori Strains from Duodenal Ulcer Patients Exhibit Mixed babA/B Genotypes with Low Levels of BabA Adhesin and Lewis b Binding. ( 27318698 )
2016
44
PERFORATED DUODENAL ULCER ASSOCIATED WITH SITUS INVERSUS AND DEXTROCARDIA. ( 27323596 )
2016
45
'Rare' manifestation of 'rare' disease: sarcoidosis presenting as pancreatitis, duodenal ulcer and severe acute kidney injury. ( 27506671 )
2016
46
Hypergastrinemia and a duodenal ulcer caused by gastric duplication. ( 27464496 )
2016
47
A Case of Eosinophilic Gastroenteritis Forming a Rigid Chamber Mimicking Giant Duodenal Ulcer on Computed Tomography Imaging. ( 27086704 )
2016
48
Expression of macrophage migration-inhibitory factor in duodenal ulcer and its relation to Helicobacter pylori infection. ( 26535701 )
2015
49
Meta-analysis of the efficacy of lansoprazole and omeprazole for the treatment of H.pylori-associated duodenal ulcer. ( 26823965 )
2015
50
Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population. ( 25829953 )
2015

Variations for Duodenal Ulcer

Expression for Duodenal Ulcer

Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for Duodenal Ulcer

Pathways related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 CXCL8 IL1B INS LTA TNF
2
Show member pathways
12.11 CXCL8 IL1B S100A8 TNF
3 11.87 CXCL8 IL1B TNF
4 11.84 CXCL8 IL1B TNF
5
Show member pathways
11.83 CXCL8 IL1B LTA TNF
6 11.81 IL1B LTA TNF
7 11.79 CXCL8 IL1B INS
8
Show member pathways
11.78 IL1B LTA TNF
9 11.77 CXCL8 IL1B IL1RN SST TNF
10 11.75 CXCL8 IL1B TNF
11 11.73 CXCL8 IL1B TNF
12 11.69 CXCL8 IL1B TNF
13 11.63 IL1B LTA TNF
14 11.59 CXCL8 IL1B TNF
15 11.54 CXCL8 IL1B LTA TNF
16 11.49 CXCL8 IL1B TNF
17
Show member pathways
11.47 CXCL8 IL1B TNF
18 11.37 CXCL8 IL1B TNF
19 11.23 CXCL8 IL1B TNF
20 10.97 IL1B TNF
21 10.95 CXCL8 IL1B IL1RN TNF
22 10.94 CXCL8 IL1B LTA TNF
23 10.9 CXCL8 TNF
24 10.82 IL1B TNF
25 10.13 GAST HRH2
26 9.77 CCK GAST GRP SCT

GO Terms for Duodenal Ulcer

Cellular components related to Duodenal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CCK CXCL8 GAST GRP IL1B IL1RN
2 extracellular space GO:0005615 9.4 CCK CXCL8 GAST GRP IL1B IL1RN
3 secretory granule lumen GO:0034774 9.33 GRP INS S100A8

Biological processes related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.91 IL1B INS LTA SST
2 inflammatory response GO:0006954 9.85 CXCL8 IL1B IL1RN S100A8 TNF
3 immune response GO:0006955 9.8 CXCL8 HRH2 IL1B IL1RN LTA TNF
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 CCK S100A8 TNF
5 neutrophil chemotaxis GO:0030593 9.73 CXCL8 IL1B S100A8
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 IL1B INS S100A8 TNF
7 positive regulation of interferon-gamma production GO:0032729 9.67 IL1B LTA TNF
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IL1B INS TNF
9 positive regulation of NF-kappaB import into nucleus GO:0042346 9.64 IL1B TNF
10 regulation of protein secretion GO:0050708 9.63 INS TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.62 LTA TNF
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.61 IL1B TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 IL1B TNF
15 positive regulation of peptide hormone secretion GO:0090277 9.58 GRP INS
16 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
17 regulation of establishment of endothelial barrier GO:1903140 9.57 IL1B TNF
18 G-protein coupled receptor signaling pathway GO:0007186 9.56 CCK CXCL8 GAST GRP HRH2 INS
19 fever generation GO:0001660 9.55 IL1B IL1RN
20 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
21 sequestering of triglyceride GO:0030730 9.52 IL1B TNF
22 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.51 LTA TNF
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IL1B TNF
24 embryonic digestive tract development GO:0048566 9.43 CXCL8 SCT TNF
25 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.37 LTA TNF
26 regulation of receptor activity GO:0010469 9.36 CCK CXCL8 GAST GRP IL1B IL1RN
27 negative regulation of lipid catabolic process GO:0050995 9.33 IL1B INS TNF
28 signal transduction GO:0007165 10.18 CCK CXCL8 GAST GRP HRH2 IL1B

Molecular functions related to Duodenal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 CXCL8 IL1B IL1RN LTA TNF
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
3 hormone activity GO:0005179 9.02 CCK GAST INS SCT SST

Sources for Duodenal Ulcer

3 CDC
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