MCID: DDN001
MIFTS: 50

Duodenal Ulcer malady

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Duodenal Ulcer

Aliases & Descriptions for Duodenal Ulcer:

Name: Duodenal Ulcer 12 52 42 14 69
Stress Ulcer 12 52 69
Curling Ulcer 12 69
Stress Ulcer of Stomach 69
Duodenal Ulcer Disease 52
Curling's Ulcers 12

Classifications:



Summaries for Duodenal Ulcer

MalaCards based summary : Duodenal Ulcer, also known as stress ulcer, is related to dextrocardia and meningitis. An important gene associated with Duodenal Ulcer is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Allograft rejection and IL-17 Family Signaling Pathways. The drugs Amoxicillin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and testes.

Related Diseases for Duodenal Ulcer

Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
id Related Disease Score Top Affiliating Genes
1 dextrocardia 29.8 IL1B IL1RN TNF
2 meningitis 29.3 CXCL8 INS TNF
3 rheumatoid arthritis 29.0 CXCL8 IL1B IL1RN LTA TNF
4 tremor, nystagmus, and duodenal ulcer 12.1
5 duodenal ulcer due to antral g-cell hyperfunction 12.0
6 peptic ulcer disease 11.1
7 chronic erosive gastritis 11.1
8 duodenitis 11.0
9 neuhauser daly magnelli syndrome 11.0
10 intussusception 10.3 IL1B TNF
11 secondary syphilis 10.3 GAST SST
12 brain edema 10.3 GAST SST
13 tau syndrome 10.3 IL1B TNF
14 gastritis 10.3
15 stocco dos santos syndrome 10.3 IL1B TNF
16 nutritional optic neuropathy 10.3 GAST SST
17 oculomotor nerve paralysis 10.3 CXCL8 IL1B
18 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.3 IL1B TNF
19 common peroneal nerve lesion 10.3 CXCL8 IL1B
20 cherubism 10.2 GAST SST
21 anal paget's disease 10.2 HRH2 IL1B TNF
22 warthin tumor 10.2 IL1B IL1RN TNF
23 benign neonatal seizures 10.2 IL1B IL1RN TNF
24 gonococcal endophthalmia 10.2 IL1B IL1RN TNF
25 pancreatitis 10.2
26 keratoconus 10.2 IL1B IL1RN TNF
27 motility-related diarrhea 10.2 IL1B IL1RN TNF
28 myocardial stunning 10.2 CCK GAST SST
29 twin-to-twin transfusion syndrome 10.2 IL1B TNF
30 immunoglobulin g deficiency 10.2 IL1B IL1RN TNF
31 amyotrophic lateral sclerosis type 14 10.2 CXCL8 IL1B TNF
32 conidiobolomycosis 10.2 CXCL8 TNF
33 parkinson disease 11 10.2 CXCL8 IL1B TNF
34 acquired thrombocytopenia 10.2 CXCL8 IL1B TNF
35 gastric cancer 10.2
36 neuropathy 10.2 CXCL8 IL1B TNF
37 inappropriate adh syndrome 10.2 CXCL8 IL1B TNF
38 ovarian cystic teratoma 10.2 CXCL8 IL1B TNF
39 labyrinthitis 10.2 CXCL8 IL1B TNF
40 atrophy of prostate 10.2 CXCL8 IL1B TNF
41 blepharochalasis 10.2 CXCL8 IL1B TNF
42 chordoid meningioma 10.2 CXCL8 IL1B TNF
43 choroiditis 10.2 CXCL8 IL1B TNF
44 sweat gland cancer 10.2 CCK GAST SST
45 band keratopathy 10.2 IL1B SST TNF
46 infancy electroclinical syndrome 10.2 CXCL8 IL1B TNF
47 red cell phospholipid defect with hemolysis 10.2 CCK SST TNF
48 balkan nephropathy 10.2 CXCL8 IL1B TNF
49 stenosis of lacrimal sac 10.2 CXCL8 IL1B TNF
50 baritosis 10.2 CXCL8 IL1B TNF

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to Duodenal Ulcer

Symptoms & Phenotypes for Duodenal Ulcer

Drugs & Therapeutics for Duodenal Ulcer

Drugs for Duodenal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 230)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613 2171
2
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
3
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
4
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3 117976-89-3 5029
5
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
6
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-78-2 2244
7
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
8
Famotidine Approved Phase 4,Phase 3 76824-35-6 3325
9
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1 75614-87-8, 51-45-6 774
10
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1 102625-70-7 4679
13
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
14
Potassium Citrate Approved, Vet_approved Phase 4,Phase 3
15
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
16
Loxoprofen Approved Phase 4 68767-14-6, 80382-23-6 3965
17
Aceclofenac Approved Phase 4 89796-99-6
18
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
19
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
20
Sulpiride Approved Phase 4 15676-16-1 5355
21
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
22
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
23
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
24
Ofloxacin Approved Phase 4 82419-36-1 4583
25
Furazolidone Approved, Vet_approved Phase 4 67-45-8 3435 5323714
26
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
27
Ethanol Approved Phase 4 64-17-5 702
28
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
29
Erythromycin Approved, Vet_approved Phase 4 114-07-8 12560
30
Ranitidine Approved Phase 4,Phase 3,Phase 1 66357-59-3, 66357-35-5 3001055
31 Trimebutine Approved Phase 4 39133-31-8
32
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
33 Benzimidazole Experimental Phase 4 51-17-2
34
Maleic acid Experimental Phase 4,Phase 1 110-16-7 444266
35 Antacids Phase 4,Phase 2,Phase 3,Phase 1
36 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
37 Anti-Infective Agents Phase 4,Phase 2,Phase 3
38 Antiparasitic Agents Phase 4,Phase 2,Phase 3
39 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
40 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
42 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3
43 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
44
Proton pump inhibitors Phase 4,Phase 2,Phase 3,Phase 1
45 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
46 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
47 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
49 Antipyretics Phase 4,Phase 2,Phase 3,Phase 1
50 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 331)
id Name Status NCT ID Phase
1 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4
2 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4
3 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4
4 Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia Unknown status NCT00978159 Phase 4
5 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4
6 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4
7 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4
8 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4
9 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
10 The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers Completed NCT00594867 Phase 4
11 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection Completed NCT00854451 Phase 4
12 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4
13 Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection Completed NCT02835560 Phase 4
14 A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn Completed NCT00237367 Phase 4
15 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
16 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
17 Study Of Celecoxib In Healthy Subjects Completed NCT00994461 Phase 4
18 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
19 A Multicenter, Double Blinded, Randomized, Parallel Assignment Study to Demonstrate the Efficacy of DA9601 Completed NCT01912066 Phase 4
20 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed NCT01353144 Phase 4
21 Celebrex Low Dose ASA Study Examining the Incidence of Gastroduodenal Ulcers in a Healthy Population Completed NCT00137033 Phase 4
22 Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion Completed NCT00843063 Phase 4
23 Ulcer Prevention Study in Post Gastric Bypass Patients Completed NCT00557349 Phase 4
24 Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers Completed NCT00778193 Phase 4
25 Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy Completed NCT00272467 Phase 4
26 The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia Completed NCT01822600 Phase 4
27 Post-Marketing Clinical Study of Rebamipide in Patients With Gastric Ulcer Completed NCT00233389 Phase 4
28 The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers Completed NCT01591083 Phase 4
29 Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer Completed NCT00239551 Phase 4
30 Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding Completed NCT00731601 Phase 4
31 A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium Completed NCT00125736 Phase 4
32 Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer Completed NCT01190657 Phase 4
33 Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy Completed NCT00164866 Phase 4
34 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients Completed NCT02648659 Phase 4
35 Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers Completed NCT00279123 Phase 4
36 The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding Completed NCT00840008 Phase 4
37 Clarithromycin Resistant Tailored Therapy Completed NCT01453036 Phase 4
38 An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium Completed NCT00428701 Phase 4
39 An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis Completed NCT01008696 Phase 4
40 Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Completed NCT02175901 Phase 4
41 Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment Completed NCT01667718 Phase 4
42 Empirical Rescue Therapies of Helicobacter Pylori Infection Completed NCT01668927 Phase 4
43 Pharmacogenetics of Gastrointestinal Bleeding Completed NCT00190255 Phase 4
44 Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori Completed NCT01667575 Phase 4
45 Esomeprazole and Gastric Emptying of Beer Completed NCT00472550 Phase 4
46 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4
47 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Completed NCT02633930 Phase 4
48 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Completed NCT02296021 Phase 4
49 Treatment of Zollinger-Ellison Syndrome With Prevacid Completed NCT00204373 Phase 4
50 The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD Completed NCT01860482 Phase 4

Search NIH Clinical Center for Duodenal Ulcer

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: duodenal ulcer

Genetic Tests for Duodenal Ulcer

Anatomical Context for Duodenal Ulcer

MalaCards organs/tissues related to Duodenal Ulcer:

39
Liver, Colon, Testes, Pancreas, Heart, Neutrophil, Endothelial

Publications for Duodenal Ulcer

Articles related to Duodenal Ulcer:

(show top 50) (show all 819)
id Title Authors Year
1
Closure of duodenal ulcer perforation using a novel endoloop device with a single-channel gastroscope after failed laparoscopic repair. ( 28068696 )
2017
2
'Rare' manifestation of 'rare' disease: sarcoidosis presenting as pancreatitis, duodenal ulcer and severe acute kidney injury. ( 27506671 )
2016
3
Hypergastrinemia and a duodenal ulcer caused by gastric duplication. ( 27464496 )
2016
4
Peritonitis Following Duodenal Ulcer Perforation in a Newborn: A Case Report. ( 28050434 )
2016
5
A life-threatening duodenal ulcer hemorrhage due to previously unknown primary hyperparathyroidism. ( 27616071 )
2016
6
PERFORATED DUODENAL ULCER ASSOCIATED WITH SITUS INVERSUS AND DEXTROCARDIA. ( 27323596 )
2016
7
Duodenal Ulcer Induced by Hem-o-Lok clip after Reduced Port Laparoscopic Cholecystectomy. ( 27014759 )
2016
8
Successful Conservative Treatment of a Cholecystoduodenal Fistula Caused by a Cytomegalovirus-associated Duodenal Ulcer. ( 27629956 )
2016
9
Helicobacter pylori Strains from Duodenal Ulcer Patients Exhibit Mixed babA/B Genotypes with Low Levels of BabA Adhesin and Lewis b Binding. ( 27318698 )
2016
10
Modeling the cost-effectiveness of ilaprazole versus omeprazole for the treatment of newly diagnosed duodenal ulcer patients in China. ( 27223846 )
2016
11
The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report. ( 27348901 )
2016
12
Pyopneumothorax and peritonitis due to perforated duodenal ulcer and associated pleuroperitoneal communication. ( 27372035 )
2016
13
Laparoscopic surgical technique for perforated duodenal ulcer. ( 26972898 )
2016
14
The Effect of Helicobacter pylori Eradication on the Gastrointestinal Microbiota in Patients with Duodenal Ulcer. ( 27308643 )
2016
15
A Non-invasive 24 Hours Stabilization of Duodenal Ulcer Perforation by a Combination Regimen. ( 28083452 )
2016
16
Helicobacter pylori and gastric or duodenal ulcer. ( 26942258 )
2016
17
Cytomegalovirus-infected duodenal ulcer with severe recurrent bleeding. ( 26852085 )
2016
18
Perforated Duodenal Ulcer. ( 26928104 )
2016
19
An Unusual Cause of Duodenal Ulcer Bleeding. ( 27091725 )
2016
20
Successful treatment of a perforated duodenal ulcer with polyglycolic acid sheets. ( 27492713 )
2016
21
A refractory duodenal ulcer with a biliary-duodenal fistula following the administration of bevacizumab. ( 27383109 )
2016
22
Association of Endoscopic Esophageal Variceal Ligation with Duodenal Ulcer. ( 27097695 )
2016
23
Weight loss and decubitus duodenal ulcer in Parkinson's disease treated with levodopa-carbidopa intestinal gel infusion. ( 27614656 )
2016
24
A Case of Eosinophilic Gastroenteritis Forming a Rigid Chamber Mimicking Giant Duodenal Ulcer on Computed Tomography Imaging. ( 27086704 )
2016
25
Sequential versus concomitant therapy for eradication of Helicobacter Pylori in patients with perforated duodenal ulcer: A randomized trial. ( 27488326 )
2016
26
History of a penetrating duodenal ulcer as a cause of acute necrotizing pancreatitis. ( 27305186 )
2016
27
An unusual case of metastatatic renal cell carcinoma presenting as melena and duodenal ulcer, 16 years after nephrectomy; a case report and review of the literature. ( 25821299 )
2015
28
Duodenal ulcer caused by a surgical clip after laparoscopic cholecystectomy. ( 26099083 )
2015
29
Laparoscopic Surgery for Perforated Duodenal Ulcer Disease: Analysis of 70 Consecutive Cases From a Single Surgeon. ( 25799260 )
2015
30
Non-healing gastro-duodenal ulcer: A rare presentation of primary abdominal tuberculosis. ( 25506841 )
2015
31
Risk factors associated with conversion of laparoscopic simple closure in perforated duodenal ulcer. ( 25644542 )
2015
32
Lethal hemorrhage from duodenal ulcer due to small pancreatic cancer. ( 26253020 )
2015
33
Polymorphisms in TLR9 but not in TLR5 increase the risk for duodenal ulcer and alter cytokine expression in the gastric mucosa. ( 25995217 )
2015
34
Chronic subclinical perforation of a duodenal ulcer presenting with an abdominal abscess in a patient with seronegative rheumatoid arthritis. ( 26150649 )
2015
35
Management of necrotising appendicitis associated with widespread necrotising enterocolitis of the small and large bowel and perforated duodenal ulcer. ( 26055603 )
2015
36
Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease. ( 25721731 )
2015
37
Changing patterns in the surgical treatment of perforated duodenal ulcer - single centre experience. ( 26649091 )
2015
38
Perforated duodenal ulcer: An unusual manifestation of allergic eosinophilic gastroenteritis. ( 26640348 )
2015
39
A case of a teenage boy with eosinophilic gastroenteritis with esophageal involvement developing a hemorrhagic duodenal ulcer. ( 26037474 )
2015
40
Parameters of proliferation and apoptosis of epithelial cells in the gastric mucosa in indigenous and non-indigenous residents of Khakassia with Helicobacter pylori positive duodenal ulcer disease. ( 25711663 )
2015
41
Expression of macrophage migration-inhibitory factor in duodenal ulcer and its relation to Helicobacter pylori infection. ( 26535701 )
2015
42
Penetrating duodenal ulcer as a cause of acute necrotizing pancreatitis. ( 26177456 )
2015
43
Intra-aortic balloon occlusion catheter for treating hemorrhagic shock after massive duodenal ulcer bleeding. ( 25633531 )
2015
44
A case of autoimmune pancreatitis associated with hemorrhagic duodenal ulcers. ( 25843458 )
2015
45
Periorbital subcutaneous emphysema: an unreported presentation of perforated duodenal ulcer. ( 25959947 )
2015
46
A rare case of duodenal ulcer perforation accompanied by Boerhaave syndrome. ( 26702287 )
2015
47
Effect of Pithecellobium dulce (Roxb.) Benth. fruit extract on cysteamine induced duodenal ulcer in rats. ( 26665296 )
2015
48
Endoscopic nasobiliary and nasopancreatic drainage contributing to healing of duodenal ulcer perforation: a case report. ( 26440686 )
2015
49
Association of Intact dupA (dupA1) rather than dupA1 cluster with duodenal ulcer in Indian population. ( 25829953 )
2015
50
Life-threatening Duodenal Ulcer Bleeding from a Ruptured Gastroduodenal Artery Aneurysm in a Patient with Neurofibromatosis Type 1. ( 26387700 )
2015

Variations for Duodenal Ulcer

Expression for Duodenal Ulcer

Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for Duodenal Ulcer

Pathways related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 CXCL8 IL1B INS LTA TNF
2
Show member pathways
12.11 CXCL8 IL1B S100A8 TNF
3 11.87 CXCL8 IL1B TNF
4 11.84 CXCL8 IL1B TNF
5
Show member pathways
11.83 CXCL8 IL1B LTA TNF
6 11.81 IL1B LTA TNF
7
Show member pathways
11.8 IL1B LTA TNF
8 11.79 CXCL8 IL1B INS
9 11.77 CXCL8 IL1B IL1RN SST TNF
10 11.75 CXCL8 IL1B TNF
11 11.73 CXCL8 IL1B TNF
12 11.69 CXCL8 IL1B TNF
13 11.63 IL1B LTA TNF
14 11.59 CXCL8 IL1B TNF
15 11.54 CXCL8 IL1B LTA TNF
16 11.49 CXCL8 IL1B TNF
17
Show member pathways
11.47 CXCL8 IL1B TNF
18 11.37 CXCL8 IL1B TNF
19 11.23 CXCL8 IL1B TNF
20 10.97 IL1B TNF
21 10.95 CXCL8 IL1B IL1RN TNF
22 10.94 CXCL8 IL1B LTA TNF
23 10.9 CXCL8 TNF
24 10.82 IL1B TNF
25 10.13 GAST HRH2
26 9.77 CCK GAST GRP SCT

GO Terms for Duodenal Ulcer

Cellular components related to Duodenal Ulcer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CCK CXCL8 GAST GRP IL1B IL1RN
2 extracellular space GO:0005615 9.4 CCK CXCL8 GAST GRP IL1B IL1RN
3 secretory granule lumen GO:0034774 9.33 GRP INS S100A8

Biological processes related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.88 IL1B INS LTA SST
2 inflammatory response GO:0006954 9.83 CXCL8 IL1B IL1RN S100A8 TNF
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.73 CCK S100A8 TNF
4 neutrophil chemotaxis GO:0030593 9.7 CXCL8 IL1B S100A8
5 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B LTA TNF
6 immune response GO:0006955 9.63 CXCL8 HRH2 IL1B IL1RN LTA TNF
7 positive regulation of NF-kappaB import into nucleus GO:0042346 9.62 IL1B TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.62 IL1B INS S100A8 TNF
9 regulation of protein secretion GO:0050708 9.61 INS TNF
10 negative regulation of growth of symbiont in host GO:0044130 9.61 LTA TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.59 IL1B TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IL1B INS TNF
15 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B TNF
16 positive regulation of peptide hormone secretion GO:0090277 9.55 GRP INS
17 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNF
18 positive regulation of fever generation GO:0031622 9.51 IL1B TNF
19 sequestering of triglyceride GO:0030730 9.49 IL1B TNF
20 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.48 LTA TNF
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IL1B TNF
22 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.26 LTA TNF
23 embryonic digestive tract development GO:0048566 9.13 CXCL8 SCT TNF
24 negative regulation of lipid catabolic process GO:0050995 8.8 IL1B INS TNF
25 signal transduction GO:0007165 10.17 CCK CXCL8 GAST GRP HRH2 IL1B

Molecular functions related to Duodenal Ulcer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 CXCL8 IL1B IL1RN LTA TNF
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
3 hormone activity GO:0005179 9.02 CCK GAST INS SCT SST

Sources for Duodenal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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