MCID: DDN006
MIFTS: 46

Duodenitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenitis

MalaCards integrated aliases for Duodenitis:

Name: Duodenitis 12 51 41 14 69
Hemorrhagic Duodenitis 12 69
Acute Enteritis of the Mouse Intestinal Tract 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8643
ICD10 32 K29.8
ICD9CM 34 535.6
MeSH 41 D004382
NCIt 46 C94409
SNOMED-CT 64 155715004 72007001

Summaries for Duodenitis

MalaCards based summary : Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and duodenal disease. An important gene associated with Duodenitis is GAST (Gastrin), and among its related pathways/superpathways are Downstream signaling events of B Cell Receptor (BCR) and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ranitidine and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and testes, and related phenotype is digestive/alimentary.

Wikipedia : 72 Duodenitis is inflammation of the duodenum. It may persist acutely or... more...

Related Diseases for Duodenitis

Diseases related to Duodenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 609)
# Related Disease Score Top Affiliating Genes
1 duodenal ulcer 33.4 GAST INS
2 duodenal disease 33.2 ATP12A ATP4A
3 peptic ulcer disease 31.8 ATP4A GAST
4 superior mesenteric artery syndrome 31.7 ATP12A ATP4A
5 multiple endocrine neoplasia, type i 31.4 GAST INS
6 gastrinoma 30.5 GAST INS
7 islet cell tumor 29.6 GAST INS
8 granulomatous gastritis 29.5 ATP12A ATP4A GAST
9 peptic esophagitis 29.5 ATP12A ATP4A
10 pancreatic islet cell tumors 29.5 GAST INS
11 bile reflux 29.5 ATP12A ATP4A
12 esophageal varix 29.5 ATP12A ATP4A
13 hernia, hiatus 29.4 ATP12A ATP4A
14 pneumatosis cystoides intestinalis 29.4 ATP12A ATP4A
15 gastric antral vascular ectasia 29.1 ATP12A ATP4A
16 laryngitis 29.1 ATP12A ATP4A
17 polyposis, skin pigmentation, alopecia, and fingernail changes 29.0 ATP12A ATP4A
18 pancreatic steatorrhea 29.0 ATP12A ATP4A
19 cloacal exstrophy 28.9 ATP12A ATP4A
20 esophagitis, eosinophilic, 1 28.8 ATP12A ATP4A
21 peptic ulcer perforation 28.7 ATP12A ATP4A GAST
22 jejunoileitis 28.6 ATP12A ATP4A CD79A
23 lymphoma, mucosa-associated lymphoid type 28.3 ATP12A ATP4A CD79A MALT1
24 lymphocytic colitis 28.2 ATP12A ATP4A CD79A
25 duodenal atresia 12.5
26 duodenal obstruction 12.1
27 duodenal gastrinoma 12.1
28 duodenal somatostatinoma 12.1
29 feingold syndrome 1 12.0
30 chronic duodenal ileus 12.0
31 neurofibromatosis-pheochromocytoma-duodenal carcinoid syndrome 12.0
32 tremor, nystagmus, and duodenal ulcer 11.9
33 duodenum cancer 11.9
34 duodenal ulcer due to antral g-cell hyperfunction 11.9
35 pancreatic lipomatosis duodenal stenosis 11.9
36 duodenal ulcer, hyperpepsinogenemic i 11.8
37 duodenal atresia tetralogy of fallot 11.8
38 pancreas, annular 11.6
39 diarrhea 5, with tufting enteropathy, congenital 11.0
40 chronic erosive gastritis 11.0
41 stromme syndrome 11.0
42 solitary median maxillary central incisor 10.8
43 familial adenomatous polyposis 1 10.8
44 xanthinuria, type i 10.8
45 xanthinuria, type ii 10.8
46 feingold syndrome 2 10.8
47 pancreatic lipase deficiency 10.8
48 immunodeficiency 12 10.8
49 mitchell-riley syndrome 10.8
50 duodenum adenoma 10.8

Comorbidity relations with Duodenitis via Phenotypic Disease Network (PDN): (show all 16)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Atrophic Gastritis
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophageal Disease Esophagitis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Paralytic Ileus

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to Duodenitis

Symptoms & Phenotypes for Duodenitis

MGI Mouse Phenotypes related to Duodenitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 ATP12A ATP4A GAST INS

Drugs & Therapeutics for Duodenitis

Drugs for Duodenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
2
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
3
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
4 Gastrointestinal Agents Phase 4,Phase 3
5 Antacids Phase 4,Phase 3
6 Anti-Ulcer Agents Phase 4,Phase 3
7 Proton pump inhibitors Phase 4,Phase 3
8 Ranitidine bismuth citrate Phase 4
9
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
10
Ofloxacin Approved Phase 3 82419-36-1 4583
11
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
12
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
13
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
14 Renal Agents Phase 3
15 Topoisomerase Inhibitors Phase 3
16 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
17 Cytochrome P-450 Enzyme Inhibitors Phase 3
18 Anti-Bacterial Agents Phase 3
19 Anti-Infective Agents Phase 3
20 Antimalarials Phase 3
21 Antiprotozoal Agents Phase 3
22 Antiparasitic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Is a Reporting System for Gastritis or Duodenitis (Modified Lanza Scale) Reproducible? Completed NCT00852150 Phase 4
2 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
3 A Two Week Nitazoxanidebased Quadruple Regimen Recruiting NCT02621359 Phase 3 Nitazoxanide;Levofloxacin;Doxycyclin;Omeprazole
4 Effectiveness of Biofeedback-Assisted Relaxation Training in Children With Eosinophilic Duodenitis Completed NCT00124501
5 Helicobacter Pylori Infection in Renal Transplant Patients Not yet recruiting NCT03310255

Search NIH Clinical Center for Duodenitis

Cochrane evidence based reviews: duodenitis

Genetic Tests for Duodenitis

Anatomical Context for Duodenitis

MalaCards organs/tissues related to Duodenitis:

38
Pancreas, Colon, Testes, Liver, T Cells, Small Intestine, Kidney

Publications for Duodenitis

Articles related to Duodenitis:

(show top 50) (show all 3025)
# Title Authors Year
1
Gastrointestinal: Duodenal variceal bleeding secondary to thrombophilia-related portal vein thrombosis. ( 29372608 )
2018
2
Tailored surgical treatment of duodenal polyposis in familial adenomatous polyposis syndrome. ( 29331402 )
2018
3
Duodenal lengthening in an adult with ultra-short bowel syndrome. A case report. ( 29106286 )
2018
4
Safety of cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a prospective exploratory study. ( 29351704 )
2018
5
A Case of Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall. ( 29434146 )
2018
6
The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding. ( 29342468 )
2018
7
Molecular Predicators of Duodenal Familial Adenomatous Polyposis Chemoprevention: Do Chemopreventive Drugs Hit Their Presumed Molecular Targets? ( 29263155 )
2018
8
Application of over-the-scope clip for massive duodenal ulcer bleeding in a 4-year-old boy weighing 7.8 kg. ( 29169193 )
2018
9
Double Duodenal Atresia: An Extremely Rare Presentation of Duodenal Obstruction. ( 29314383 )
2018
10
Duodenal amyloidosis secondary to ulcerative colitis. ( 29422811 )
2018
11
Teratoma Arising from Hepato Duodenal Ligament in the Newborn with Transection of Portal Vein, Hepatic Artery and Common Bile Duct: A Surgical Challenge. ( 29386766 )
2018
12
A rare mass in the duodenal bulb: Brunner's glands cystadenoma. ( 29368943 )
2018
13
Megaduodenum in a 59-year-old man: a very late postoperative complication after duodenal atresia. ( 29351932 )
2018
14
International study of endoscopic management of distal malignant biliary obstruction combined with duodenal obstruction. ( 28982258 )
2018
15
In with acute bronchitis; out with duodenal perforation: the potentially harmful cascade of over-testing. A case report. ( 29441163 )
2018
16
An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma. ( 29391323 )
2018
17
Extracardiac Tumor From Duodenal Primary Gastrointestinal Stromal Tumor. ( 29279471 )
2017
18
Duodenal Ulcer - IgA Vasculitis. ( 28202872 )
2017
19
Acute kidney injury following vomiting and diarrhea after endoscopy in a duodenal gastrinoma patient. ( 28070096 )
2017
20
Severe muscle fasciculations and tremor in a cat with hypochloraemic metabolic alkalosis secondary to duodenal obstruction. ( 28491446 )
2017
21
Report of two cases of large cell neuroendocrine carcinoma of duodenal ampulla with contrasting outcomes following pancreaticoduodenectomy according to the use of adjuvant chemotherapy. ( 28160741 )
2017
22
A rare cause of recurrent acute pancreatitis: duodenum intussusception by a fenestrated duodenal web. ( 28342893 )
2017
23
Duodenal Gastrinoma Discovered on Evaluation for Incidental Gastric Carcinoid. ( 28300688 )
2017
24
Duodenal Atresia And Stenosis ( 29261981 )
2017
25
Malignant Duodenal GIST in a Patient with Situs Inversus Totalis-a Rare Association and Brief Review of Literature. ( 28567619 )
2017
26
Intravascular large B cell lymphoma diagnosed in random duodenal biopsies. A case report and a literature review. ( 28474092 )
2017
27
Perforated Duodenal Ulcer. ( 28248764 )
2017
28
Advanced duodenal neoplasia and carcinoma in familial adenomatous polyposis: outcomes of surgical management. ( 29184692 )
2017
29
A unique complication of self-expandable metal stent placement in malignant duodenal obstruction. ( 28928926 )
2017
30
Adapted ERAS Pathway vs. Standard Care in Patients with Perforated Duodenal Ulcer-a Randomized Controlled Trial. ( 28653239 )
2017
31
Duodenal Atresia: Open versus MIS Repair-Analysis of Our Experience over the Last 12 Years. ( 28326320 )
2017
32
Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer. ( 28465717 )
2017
33
Allelic frequencies of the hs1.2 enhancer within the immunoglobulin heavy chain region in Dayton, Ohio patients screened for celiac disease with duodenal biopsy. ( 28473300 )
2017
34
Successful Endoscopic Treatment of Bouveret Syndrome in a Patient with Choledochoduodenal Fistula Complicating Duodenal Ulcer. ( 28758036 )
2017
35
EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER. ( 28977115 )
2017
36
Henoch-SchAPnlein Purpura with Concurrent Cytomegalovirus Duodenitis. ( 28271648 )
2017
37
An Atypical Case of Leishmaniasis Associated with Chronic Duodenitis in a Dog. ( 28282232 )
2017
38
Emphysematous pancreatitis associated with penetrating duodenal ulcer. ( 29358874 )
2017
39
PDX1 Gene Mutation with Permanent Neonatal Diabetes Mellitus with Annular Pancreas, Duodenal Atresia, Hypoplastic Gall Bladder and Exocrine Pancreatic Insufficiency. ( 29317564 )
2017
40
Pilot study: duodenal MDR1 and COX2 gene expression in cats with inflammatory bowel disease and low-grade alimentary lymphoma. ( 28948903 )
2017
41
Prenatal sonographic diagnosis of meconium peritonitis from duodenal atresia. ( 28159774 )
2017
42
Endocytoscopy of Superficial Nonampullary Duodenal Epithelial Tumor: Two Cases of Tubular Adenocarcinoma and Adenoma. ( 29109501 )
2017
43
ExposAc: Different Faces of a Bleeding Giant Duodenal Ulcer. ( 28871345 )
2017
44
BRUNNER GLAND ADENOMA MASQUERADING AS DUODENAL GASTROINTESTINAL STROMAL TUMOR WITH INTUSSUSCEPTION: CASE REPORT. ( 28489176 )
2017
45
Duodenal gastrointestinal stromal tumor A case report. ( 28874632 )
2017
46
Cytomegalovirus duodenitis associated with life-threatening duodenal hemorrhage in an immunocompetent patient: A case report. ( 28292662 )
2017
47
Laparoscopic versus open surgery in management of congenital duodenal obstruction in neonates: a single-center experience with 112 cases. ( 28943138 )
2017
48
Twin pregnancy complicated by esophageal atresia, duodenal atresia, gastric perforation, and hypoplastic left heart structures in one twin: a case report and review of the literature. ( 28314387 )
2017
49
Transition from Laparotomy to Laparoscopic Repair of Congenital Duodenal Obstruction in Neonates: Our Early Experience. ( 29018788 )
2017
50
Annular pancreas causing duodenal obstruction in an adult. ( 28500113 )
2017

Variations for Duodenitis

Expression for Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for Duodenitis

Pathways related to Duodenitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 CD79A INS MALT1
2 11.14 CD79A INS
3 9.32 ATP4A GAST

GO Terms for Duodenitis

Biological processes related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proton transport GO:0015992 9.16 ATP12A ATP4A
2 B cell activation GO:0042113 8.96 CD79A MALT1
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Duodenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....