MCID: DDN006
MIFTS: 62

Duodenitis malady

Gastrointestinal diseases category

Summaries for Duodenitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Duodenitis is inflammation of the duodenum. It may persist acutely or chronically. more...

MalaCards: Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and gastric ulcer. An important gene associated with Duodenitis is CYBRD1 (cytochrome b reductase 1), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Mineral absorption. The compounds calcium and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and testes, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Duodenitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

duodenitis 8 10 44
hemorrhagic duodenitis 8 60
acute enteritis of the mouse intestinal tract 60


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Disease Ontology8 DOID:8643
ICD9CM27 535.6
SNOMED-CT56 155715004, 72007001
MeSH34 D004382
ICD1025 K29.8

Related Diseases for Duodenitis

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17GeneCards, 18GeneDecks
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Diseases related to Duodenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 472)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer31.8HRH2, IL1RN, SST, GRP, DEFB4A, DEFB1
2gastric ulcer31.3HRH2, TFF1, GAST, S100A8
3pancreatitis31.3SST, SCT, CCK
4gastritis31.0S100A8, SCT, GAST, DEFB4A, IL1RN
5esophagitis30.8S100A8, GAST, HRH2
6somatostatinoma30.7SST, GAST
7dyspepsia30.7CCK, GAST, HRH2
8gastrinoma30.7SCTR, SCT, GAST, GRP, SST
9peptic ulcer30.7CCK, S100A8, SCT, GAST, HRH2, SST
10adenoma30.7S100A8, SCT, GAST, TFF1, SST
11acute pancreatitis30.6CCK, SCT, SST, IL1RN, HRH2
12adenocarcinoma30.6CCK, S100A8, PDX1, SCTR, SCT, GAST
13celiac disease30.5CCK
14zollinger-ellison syndrome30.5SCT, GAST, GRP, SST, HRH2
15pancreatic cancer30.5CCK, SCT, GAST, TFF1, SST
16gastroduodenitis30.5GAST
17duodenal neoplasm30.4S100G, SST
18duodenogastric reflux30.4CCK, GAST
19hepatitis30.4HRH2
20paraganglioma30.4GAST, GRP, SST
21obesity30.4CCK, GRP
22neuroendocrine tumor30.3SST
23ulcerative colitis30.2IL1RN, DEFB4A, DEFB1, TFF1
24insulinoma30.2PDX1, SCT, GAST, GRP, SST
25diarrhea30.2SST, GAST
26hemochromatosis30.2SLC40A1, CYBRD1
27atrophic gastritis30.1IL1RN, SST, TFF1, GAST, SCT, S100A8
28steatorrhea30.1SST, SCT, CCK
29alcoholic pancreatitis30.1CCK, SCT
30angiodysplasia30.1SST
31diabetes mellitus30.0SST, SCT, PDX1, CCK
32neuroendocrine carcinoma30.0SST, GRP, HDC, GAST
33sarcoidosis30.0IL1RN, GRP, DEFB4A, DEFB1
34bile reflux30.0TFF1, CCK
35hepatocellular carcinoma30.0S100A8, SCT, GRP
36stomach cancer29.9S100A8, GAST, TFF1, HDC, DEFB4A, GRP
37gastric adenocarcinoma29.9S100A8, GAST, TFF1, DEFB4A, GRP, IL1RN
38inflammatory bowel disease29.9S100A8, SCT, TFF1, DEFB1, DEFB4A, IL1RN
39gastroesophageal reflux disease29.9CCK, S100A8, SCT, GAST, HRH2
40cystic fibrosis29.9S100A8, SCTR, SCT, DEFB1, DEFB4A
41hypoglycemia29.9SST, GAST, SCT
42breast cancer29.9GRP, HDC, TFF1, S100A8
43islet cell tumor29.9GAST, SST
44hyperparathyroidism29.9SCT, GAST
45liver cirrhosis29.9SCT
46colorectal cancer29.8S100A8, GAST, TFF1, GRP, IL1RN
47wermer syndrome29.8SCT, GAST, SST
48barrett's esophagus29.8TFF1, GAST, S100A8
49irritable bowel syndrome29.8CCK
50arthritis29.8S100A8, IL1RN, HRH2

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to duodenitis

Clinical Features for Duodenitis

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Drugs & Therapeutics for Duodenitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Duodenitis

Search CenterWatch for Duodenitis

Genetic Tests for Duodenitis

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Anatomical Context for Duodenitis

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32MalaCards
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MalaCards organs/tissues related to Duodenitis:

32
Pancreas, Colon, Testes, Liver, Small intestine, T cells, Lymph node, Lung, Kidney, Thyroid, Breast, Heart, Bone, Endothelial, B cells, Myeloid, Pancreatic islet, Bone marrow, Ovary, Skin, Spleen, Monocytes, Pituitary, Smooth muscle

Animal Models for Duodenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Duodenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.8PTF1A, CCK, S100G, PDX1, SCTR, SCT
2MP:000538711.3SCTR, GAST, HDC, DEFB1, SST, IL1RN
3MP:000538110.9PDX1, GAST, TFF1, SST, HRH2, SLC40A1

Publications for Duodenitis

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50PubMed
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Articles related to Duodenitis:

(show top 50)    (show all 2591)
idTitleAuthorsYear
1
Utility of tissue transglutaminase immunohistochemistry in pediatric duodenal biopsies: patterns of expression and role in celiac disease-a clinicopathologic review. (24195009)
2013
2
Management of duodenal ulcer bleeding resistant to endoscopy: surgery is dead! (23467545)
2013
3
Endoscopic duodenal-jejunal bypass liner rapidly improves plasma parameters of nonalcoholic fatty liver disease. (23920034)
2013
4
Duodenal perforation in an infant with rotavirus gastroenteritis. (23592811)
2013
5
A case of mesenteric cystic lymphangioma in an adult which caused duodenal stenosis after resection. (23287062)
2013
6
Endoscopic management of duodenal adenomas in familial adenomatous polyposis--a single-center experience. (21960285)
2012
7
The significance of duodenal mucosal atrophy in patients with common variable immunodeficiency: a clinical and histopathologic study. (22904128)
2012
8
An unusual case of ulcerative duodenitis. (21722640)
2011
9
Annular pancreas: a rare cause of duodenal obstruction in adults. (22468072)
2011
10
Duodenal ulcer perforation: a district hospital experience. (21520783)
2011
11
Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. (19901909)
2010
12
Sequential or simultaneous placement of self-expandable metallic stents for palliation of malignant biliary and duodenal obstruction due to unresectable pancreatic head carcinoma. (21150420)
2010
13
Increased expression of serum- and glucocorticoid-regulated kinase-1 in the duodenal mucosa of children with coeliac disease. (19966577)
2010
14
Etiology and pathogenesis of duodenal mucosa lesion in chronic pancreatitis]. (19334494)
2009
15
Effect of central administration of ondansetron, a 5-hydroxytryptamine-3 receptor antagonist on gastric and duodenal ulcers. (19527299)
2009
16
Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes. (19237517)
2009
17
New molecular mechanisms of duodenal ulceration. (17656571)
2007
18
Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein beta. (17705277)
2007
19
Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human. (17373738)
2007
20
Changes in reducing power profile of gastric juice in patients with active duodenal ulcer. (16095868)
2005
21
Duodenal dearterialization and stapling for severe hemorrhage from duodenal varices with portal vein thrombosis. (15701491)
2005
22
Th response to Helicobacter pylori differs between patients with gastric ulcer and duodenal ulcer. (16036523)
2005
23
Evidence for acid-induced loss of Cdx2 expression in duodenal gastric metaplasia. (15258992)
2004
24
Genetic polymorphism of interleukin-8 (IL-8) is associated with Helicobacter pylori-induced duodenal ulcer. (15627645)
2004
25
Effect of Helicobacter pylori eradication on the ulcer recurrence rate after simple closure of perforated duodenal ulcer: retrospective and prospective randomized controlled studies. (11488789)
2001
26
Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. (10930902)
2000
27
Extrinsic duodenal obstruction from anomalous congenital band. (17264645)
2000
28
Combined pure esophageal atresia, duodenal atresia, biliary atresia, and pancreatic ductal atresia: prenatal diagnostic features and review of the literature. (10813340)
2000
29
Metallic stents in the treatment of duodenal obstruction: technical issues and results. (10786921)
2000
30
Management of Helicobacter pylori in duodenal ulcer: a cost-effectiveness analysis. (11121912)
2000
31
HLA-DQA1 genes involved in the genetic susceptibility to duodenal ulcer in Wuhan Hans]. (10194252)
1999
32
Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts. (9623669)
1998
33
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function. (9073129)
1997
34
Sucralfate suppresses Helicobacter pylori infection and reduces gastric acid secretion by 50% in patients with duodenal ulcer. (8608880)
1996
35
Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients. (8777296)
1996
36
Gastric juice epidermal growth factor concentration and Helicobacter pylori in patients with duodenal ulcer. (7551996)
1995
37
Analysis of duodenal bile acids in patients with colorectal tumors and control subjects]. (8550804)
1995
38
Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. (7657096)
1995
39
Prospective randomized study comparing three surgical techniques for the treatment of gastric outlet obstruction secondary to duodenal ulcer. (8101050)
1993
40
Endogenous dopamine and duodenal bicarbonate secretion in humans. (8482451)
1993
41
Duodenal atresia: a source of small bowel obstruction in a 5-week-old infant. (1386921)
1992
42
Endoscopic gastritis and duodenitis. (1559492)
1992
43
Changes in peptic ulcer and gastritis/duodenitis in Great Britain, 1970-1985. (1968072)
1990
44
Outcome of ulcer-associated duodenitis after short-term medical treatment. (4006645)
1985
45
Intramural duodenal hematoma in children. The role of the radiologist in its conservative management. (1088718)
1976
46
Congenital intrinsic duodenal obstruction: a twenty-year review of its surgical management and consequences. (4430966)
1974
47
Extrinsic duodenal obstruction in children. (4682270)
1973
48
A case of coexisting duodenal uceration and idiopathic steatorrhea. (5686665)
1968
49
Plummer-Vinson syndrome caused by hemorrhagic duodenal diverticulosis]. (13634576)
1959
50
Duodenal obstruction. (15422171)
1950

Genetic Variations for Duodenitis

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Expression for genes affiliated with Duodenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for genes affiliated with Duodenitis

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Duodenitis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Duodenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.1HRH2, S100A8, PDX1, SCTR, SCT, GAST
2retinoic acid44 2413.0PDX1, SCT, HRH2, TFF1, HDC, DEFB4A
3histamine44 28 2413.9IL1RN, CCK, GAST, SCT, HDC, DEFB4A
4glutamate4411.7IL1RN, SST, GRP, HDC, S100G, GAST
5adenylate4411.6SCT, SST, HRH2, CCK, IL1RN, GAST
6omeprazole44 28 49 11 2415.6CCK, SCT, GAST, HDC, SST, HRH2
7gaba4411.6GAST, CCK, S100G, GRP, SST, HDC
8acetylcholine44 49 28 11 2415.5SCTR, CCK, SCT, GAST, GRP, SST
9atropine44 28 1113.5GRP, GAST, SST, CCK, HRH2, SCT
10dexamethasone44 49 28 1114.4DEFB1, DEFB4A, CCK, GRP, TFF1, S100A8
11acth4411.4IL1RN, SST, GRP, GAST, SCT, CCK
12loxiglumide4411.4SST, GAST, SCT, CCK, GRP
13pepsinogen4411.4SCT, GAST, GRP, HRH2, CCK
14rantes4411.4IL1RN, DEFB4A, DEFB1, HDC, S100A8, SCT
15pirenzepine44 28 1113.4CCK, HRH2, GRP, GAST, SST
16oxyntomodulin44 5912.4CCK, GAST, SST, GRP, SCT
17epinephrine44 11 2413.4SCT, GAST, SST, HRH2, GRP, IL1RN
18testosterone44 59 11 2414.4IL1RN, GRP, CCK, SCT, GAST, TFF1
19octreotide44 59 28 1114.3SCT, GAST, GRP, SST, CCK
20c-peptide4411.3SST, SCT, CCK, PDX1, GAST
21bicarbonate4411.3SCT, SCTR, CCK, HRH2, GAST
22norepinephrine44 11 2413.3GAST, IL1RN, SCT, CCK, SST, GRP
23lafutidine4411.3SST, HRH2, GAST, SCT
24minigastrin4411.3GRP, GAST, CCK, SST
25bethanechol44 28 1113.3GRP, SST, GAST, CCK
26amoxicillin44 49 1113.3GAST, S100A8, IL1RN, HRH2
27ibmx44 28 5913.2SCT, TFF1, GRP, SST, CCK
28dtpa4411.2SST, CCK, GRP, GAST
29clarithromycin44 1112.2GAST, IL1RN, HRH2, S100A8
30carbachol44 28 1113.2CCK, SCT, GAST, GRP, SST
31ranitidine44 28 11 2414.2HRH2, GAST, SCT, CCK
325-hydroxytryptamine4411.2SST, HRH2, GRP, CCK, GAST
33isoproterenol44 1112.2HRH2, SCT, GRP, GAST, SST
34taurodeoxycholate4411.1SCT, SST, CCK
35l-bpa4411.1SCTR, SCT, CCK
36caerulein4411.1CCK, GRP, SCT
37pancreozymin4411.1GAST, SCT, CCK
38pge24411.1SST, GRP
39enprostil28 4412.1HRH2, SST, GAST
40cerulein4411.1CCK, SCT, GRP
41peptone4411.1GAST, GRP, CCK
42tetrodotoxin44 59 2813.0HRH2, GRP, CCK, SCT
43aspirin44 49 28 2414.0TFF1, CCK, HRH2, IL1RN, GRP
44neomycin4411.0CCK, GAST, GRP, PDX1
45propranolol44 28 49 11 2415.0SCT, SST, GAST, GRP
46pantoprazole44 49 11 2414.0SST, GAST, HRH2
47domperidone44 28 1112.8HRH2, GAST, SST
48lansoprazole49 44 11 2413.8HRH2, GAST, IL1RN
49amide4410.7HDC, GAST, S100G, CCK
50dopamine44 28 11 2413.7GAST, SST, GRP, HDC, SCT, CCK

GO Terms for genes affiliated with Duodenitis

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16Gene Ontology
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Cellular components related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0IL1RN, SST, GRP, TFF1, S100A8, CCK
2extracellular regionGO:00557610.9SST, CCK, S100A8, SCT, GAST, DEFB1

Biological processes related to Duodenitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718611.2SST, DEFB4A, DEFB1, GAST, SCTR
2endocrine pancreas developmentGO:03101810.9PDX1, PTF1A, RFX6
3digestionGO:00758610.9SST, TFF1, SCTR
4cellular iron ion homeostasisGO:00687910.9CYBRD1, SLC46A1, SLC40A1
5type B pancreatic cell differentiationGO:00330910.9RFX6, PDX1
6immune responseGO:00695510.9HRH2, IL1RN, DEFB4A, DEFB1
7exocrine pancreas developmentGO:03101710.7PTF1A, PDX1
8response to iron ionGO:01003910.7CYBRD1, TFF1
9acute inflammatory responseGO:00252610.6DEFB1, S100A8
10defense response to bacteriumGO:04274210.5S100A8, DEFB1, DEFB4A

Molecular functions related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.9SST, GAST, SCT, CCK

Products for genes affiliated with Duodenitis

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Sources for Duodenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet