MCID: DDN006
MIFTS: 54

Duodenitis malady

Gastrointestinal category

Summaries for Duodenitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Duodenitis is inflammation of the duodenum. It may persist acutely or chronically. more...

MalaCards: Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and gastric ulcer. An important gene associated with Duodenitis is CYBRD1 (cytochrome b reductase 1), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Mineral absorption. The compounds calcium and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and small intestine, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Duodenitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

duodenitis 8 10 45
hemorrhagic duodenitis 8 61
acute enteritis of the mouse intestinal tract 61


External Ids:

Disease Ontology8 DOID:8643
ICD9CM27 535.6
SNOMED-CT57 155715004, 72007001
MeSH35 D004382
ICD1025 K29.8

Related Diseases for Duodenitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Duodenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 434)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer31.8HRH2, IL1RN, SST, GRP, DEFB4A, DEFB1
2gastric ulcer31.3HRH2, TFF1, GAST, S100A8
3adenoma31.0S100A8, SCT, GAST, TFF1, SST
4somatostatinoma30.8SST, GAST
5dyspepsia30.8CCK, GAST, HRH2
6gastrinoma30.8SCTR, SCT, GAST, GRP, SST
7acute pancreatitis30.7CCK, SCT, SST, IL1RN, HRH2
8adenocarcinoma30.6CCK, S100A8, PDX1, SCTR, SCT, GAST
9pancreatitis, chronic30.6CCK, SCT, TFF1, GRP, SST
10celiac disease30.6CCK
11zollinger-ellison syndrome30.6SCT, GAST, GRP, SST, HRH2
12duodenogastric reflux30.5CCK, GAST
13paraganglioma30.5GAST, GRP, SST
14ulcerative colitis30.3IL1RN, DEFB4A, DEFB1, TFF1
15multiple endocrine neoplasia30.3GAST
16insulinoma30.2PDX1, SCT, GAST, GRP, SST
17hemochromatosis30.2SLC40A1, CYBRD1
18atrophic gastritis30.2IL1RN, SST, TFF1, GAST, SCT, S100A8
19steatorrhea30.2SST, SCT, CCK
20alcoholic pancreatitis30.1CCK, SCT
21angiodysplasia30.1SST
22neuroendocrine carcinoma30.1SST, GRP, HDC, GAST
23bile reflux30.1TFF1, CCK
24stomach cancer30.0S100A8, GAST, TFF1, HDC, DEFB4A, GRP
25carcinoid syndrome30.0CCK, SCT, GAST, HDC, GRP, SST
26gastroesophageal reflux disease30.0CCK, S100A8, SCT, GAST, HRH2
27cystic fibrosis30.0S100A8, SCTR, SCT, DEFB1, DEFB4A
28hypoglycemia30.0SST, GAST, SCT
29gastroduodenitis30.0GAST
30asthma29.8HRH2, DEFB4A, DEFB1, HDC, SCT, S100A8
31glucagonoma29.8CCK, PDX1, SCT, GAST, SST
32colorectal cancer29.8S100A8, GAST, TFF1, GRP, IL1RN
33wermer syndrome29.8SCT, GAST, SST
34irritable bowel syndrome29.8CCK
35arthritis29.8S100A8, IL1RN, HRH2
36thyroid medullary carcinoma29.6CCK, GAST, TFF1, GRP, SST
37cholera29.6CCK, SCT, TFF1, GRP
38glucose intolerance29.6HRH2, GAST, CCK
39barrett's esophagus29.6TFF1, GAST, S100A8
40acromegaly29.6SST, CCK
41hyperinsulinemic hypoglycemia29.6GAST, SST
42cholelithiasis29.6CCK, SST
43apudoma29.6SST
44dumping syndrome29.6SST
45anorexia nervosa29.6CCK
46duodenal atresia10.9
47h. pylori infection10.7
48annular pancreas10.6
49familial adenomatous polyposis10.6
50gastric outlet obstruction10.6

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to duodenitis

Clinical Features for Duodenitis

Drugs & Therapeutics for Duodenitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Duodenitis

Search CenterWatch for Duodenitis

Genetic Tests for Duodenitis

Anatomical Context for Duodenitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Duodenitis:

33
Bone marrow, Heart, Small intestine, Colon, Pancreas, T cells

Animal Models for Duodenitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Duodenitis

Sources:
51PubMed
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Articles related to Duodenitis:

(show top 50)    (show all 244)
idTitleAuthorsYear
1
Acute segmentary ulcerative duodenitis induced by Streptococcus pyogenes mimicking inflammatory bowel disease. (23994254)
2013
2
Obstructive Jaundice Secondary to Primary Duodenal Lymphoma with CMV Duodenitis Causing Upper GI Bleed in Retro-Positive Patient: A Case Report. (24426393)
2013
3
Cytomegalovirus duodenitis associated with acquired immunodeficiency syndrome. (23363302)
2013
4
A case of ischemic duodenitis associated with superior mesenteric artery syndrome caused by an abdominal aortic aneurysm. (21887129)
2011
5
Electronic images of the month. Severe duodenitis after massive chronic Ibuprofen overdose. (20601140)
2010
6
Hemorrhagic gastritis and duodenitis following celiac plexus neurolysis. (19935986)
2009
7
Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin-10-deficient mice. (19235917)
2009
8
Treatment of radiation-induced hemorrhagic duodenitis with argon plasma coagulation. (14765324)
2004
9
Endoscopic duodenitis, gastric metaplasia and Helicobacter pylori. (11350546)
2001
10
Nodular duodenitis involving CD8+ cell infiltration in patients with ulcerative colitis. (11813583)
2001
11
A rare case of multiple carcinoids and endocrine cell micronests in a patient with chronic duodenitis. (10964325)
2000
12
Radiologic evaluation of gastritis and duodenitis. (10430136)
1999
13
On the pathogenesis and treatment of erosive gastritis and duodenitis]. (10380457)
1999
14
Duodenitis in children: correlation of radiologic findings with endoscopic and pathologic findings. (9423658)
1998
15
Endoscopic appearance of cryptosporidial duodenitis. (8855757)
1996
16
An investigation of the role of Fusarium moniliforme in duodenitis/proximal jejunitis of horses. (7709589)
1995
17
Duodenitis--distinguishing features in a retrospective endoscopic and histological study. (7721239)
1994
18
Refractory graft duodenitis and bleeding following enteric diversion of transplanted pancreas with bladder drainage. (8066754)
1994
19
Mucosal blood flow in erosive duodenitis. (8228079)
1993
20
Significance of chronic duodenitis. (8512874)
1993
21
Endoscopic gastritis and duodenitis. (1559492)
1992
22
Natural history of erosive duodenitis. (1442706)
1992
23
Patients with duodenitis have gastric secretory and motor functions like those of duodenal ulcer patients: results of a short-term treatment with ranitidine. (2066545)
1991
24
A case of hypereosinophilic syndrome followed by bronchial asthma, intraventricular thrombus, and duodenitis]. (1753511)
1991
25
The Sydney System: endoscopic division. Endoscopic appearances in gastritis/duodenitis. (1912432)
1991
26
Changes in peptic ulcer and gastritis/duodenitis in Great Britain, 1970-1985. (1968072)
1990
27
Ulcerative duodenitis with luminal constriction in two horses. (2347756)
1990
28
Long-term technology assessment. Mortality, hospitalization, and work loss due to peptic ulcer and gastritis/duodenitis in the Federal Republic of Germany. (10292969)
1989
29
Increased incidence of duodenitis in chronic renal failure. (3195978)
1988
30
The histological and ultrastructural studies of the duodenal mucosa in acute gastritis, gastric ulcer, chronic nonspecific duodenitis, duodenal ulcer and esophageal varices. (3221147)
1988
31
Gastro-duodenitis: bits and bugs. (3294167)
1988
32
Duodenitis and secretion of O-acetylated sialomucin variants. (3209190)
1988
33
Duodenitis in children: clinical, endoscopic, and pathological aspects. (3678763)
1987
34
Outcome of ulcer-associated duodenitis after short-term medical treatment. (4006645)
1985
35
Duodenitis and ulcer relapse. (2862449)
1985
36
Duodenitis--any progress? (2866297)
1985
37
Duodenitis: a clinical, endoscopic and histopathologic study. (4059506)
1985
38
Pain provocation test in peptic duodenitis. (6315525)
1983
39
Gastritis, duodenitis, and peptic ulcer disease: Fourth International Symposium. (6119338)
1981
40
Natural history of chronic duodenitis: incidence in Nigerians. (7265283)
1981
41
Measurements of intestinal villi non-specific and ulcer-associated duodenitis-correlation between area of microdissected villus and villus epithelial cell count. (7309898)
1981
42
Proceedings: The diagnosis of duodenitis. (4434976)
1974
43
Hemorrhagic duodenitis: a significant cause of gastrointestinal bleeding. (4543164)
1973
44
The cobblestone appearance of the duodenal cap, duodenitis and hyperplasia of Brunner's glands. (5475773)
1970
45
Duodenitis. Significance and frequency. (5317493)
1970
46
Does alcohol cause duodenitis? (4888119)
1969
47
Granulomatous duodenitis, clubbed digits, and psoriasis: report of a case. (6044529)
1967
48
Dyspepsia, duodenitis and hookworm infection. (6005947)
1966
49
Hyperchlorhydria, duodenitis and duodenal ulcer: a clinical study of their interrelationships. (14429329)
1959
50
Duodenitis and alkalosis. (18898135)
1948

Genetic Variations for Duodenitis

Expression for genes affiliated with Duodenitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for genes affiliated with Duodenitis

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Duodenitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Duodenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2415.1HRH2, S100A8, PDX1, SCTR, SCT, GAST
2retinoic acid45 2413.0PDX1, SCT, HRH2, TFF1, HDC, DEFB4A
3histamine45 29 2413.9IL1RN, CCK, GAST, SCT, HDC, DEFB4A
4glutamate4511.7IL1RN, SST, GRP, HDC, S100G, GAST
5adenylate4511.6SCT, SST, HRH2, CCK, IL1RN, GAST
6omeprazole45 29 50 11 2415.6CCK, SCT, GAST, HDC, SST, HRH2
7gaba4511.6GAST, CCK, S100G, GRP, SST, HDC
8acetylcholine45 50 29 11 2415.5SCTR, CCK, SCT, GAST, GRP, SST
9atropine45 29 1113.5GRP, GAST, SST, CCK, HRH2, SCT
10dexamethasone45 50 29 1114.4DEFB1, DEFB4A, CCK, GRP, TFF1, S100A8
11acth4511.4IL1RN, SST, GRP, GAST, SCT, CCK
12loxiglumide4511.4SST, GAST, SCT, CCK, GRP
13pepsinogen4511.4SCT, GAST, GRP, HRH2, CCK
14rantes4511.4IL1RN, DEFB4A, DEFB1, HDC, S100A8, SCT
15pirenzepine45 29 1113.4CCK, HRH2, GRP, GAST, SST
16oxyntomodulin45 6012.4CCK, GAST, SST, GRP, SCT
17epinephrine45 11 2413.4SCT, GAST, SST, HRH2, GRP, IL1RN
18testosterone45 60 11 2414.4IL1RN, GRP, CCK, SCT, GAST, TFF1
19octreotide45 60 29 1114.3SCT, GAST, GRP, SST, CCK
20c-peptide4511.3SST, SCT, CCK, PDX1, GAST
21bicarbonate4511.3SCT, SCTR, CCK, HRH2, GAST
22norepinephrine45 11 2413.3GAST, IL1RN, SCT, CCK, SST, GRP
23lafutidine4511.3SST, HRH2, GAST, SCT
24minigastrin4511.3GRP, GAST, CCK, SST
25bethanechol45 29 1113.3GRP, SST, GAST, CCK
26amoxicillin45 50 1113.3GAST, S100A8, IL1RN, HRH2
27ibmx45 29 6013.2SCT, TFF1, GRP, SST, CCK
28dtpa4511.2SST, CCK, GRP, GAST
29clarithromycin45 1112.2GAST, IL1RN, HRH2, S100A8
30carbachol45 29 1113.2CCK, SCT, GAST, GRP, SST
31ranitidine45 29 11 2414.2HRH2, GAST, SCT, CCK
325-hydroxytryptamine4511.2SST, HRH2, GRP, CCK, GAST
33isoproterenol45 1112.2HRH2, SCT, GRP, GAST, SST
34taurodeoxycholate4511.1SCT, SST, CCK
35l-bpa4511.1SCTR, SCT, CCK
36caerulein4511.1CCK, GRP, SCT
37pancreozymin4511.1GAST, SCT, CCK
38pge24511.1SST, GRP
39enprostil29 4512.1HRH2, SST, GAST
40cerulein4511.1CCK, SCT, GRP
41peptone4511.1GAST, GRP, CCK
42tetrodotoxin45 60 2913.0HRH2, GRP, CCK, SCT
43aspirin45 50 29 2414.0TFF1, CCK, HRH2, IL1RN, GRP
44neomycin4511.0CCK, GAST, GRP, PDX1
45propranolol45 29 50 11 2415.0SCT, SST, GAST, GRP
46pantoprazole45 50 11 2414.0SST, GAST, HRH2
47domperidone45 29 1112.8HRH2, GAST, SST
48lansoprazole50 45 11 2413.8HRH2, GAST, IL1RN
49amide4510.7HDC, GAST, S100G, CCK
50dopamine45 29 11 2413.7GAST, SST, GRP, HDC, SCT, CCK

GO Terms for genes affiliated with Duodenitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0IL1RN, SST, GRP, TFF1, S100A8, CCK
2extracellular regionGO:00557610.9SST, CCK, S100A8, SCT, GAST, DEFB1

Biological processes related to Duodenitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718611.2GAST, DEFB1, DEFB4A, SST, SCTR
2endocrine pancreas developmentGO:03101810.9RFX6, PTF1A, PDX1
3digestionGO:00758610.9SST, TFF1, SCTR
4cellular iron ion homeostasisGO:00687910.9SLC40A1, CYBRD1, SLC46A1
5type B pancreatic cell differentiationGO:00330910.9RFX6, PDX1
6immune responseGO:00695510.9DEFB1, DEFB4A, IL1RN, HRH2
7exocrine pancreas developmentGO:03101710.7PTF1A, PDX1
8response to iron ionGO:01003910.7TFF1, CYBRD1
9acute inflammatory responseGO:00252610.6DEFB1, S100A8
10defense response to bacteriumGO:04274210.5DEFB4A, DEFB1, S100A8

Molecular functions related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.9SST, GAST, SCT, CCK

Products for genes affiliated with Duodenitis

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Sources for Duodenitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet