MCID: DDN006
MIFTS: 56

Duodenitis malady

Gastrointestinal diseases category

Summaries for Duodenitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Duodenitis is inflammation of the duodenum. It may persist acutely or chronically. more...

MalaCards: Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and gastritis. An important gene associated with Duodenitis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Selected targets of GCR alpha and Insulin receptor recycling. The compounds calcium gluconate and i-app have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and testes, and related mouse phenotypes are immune system and digestive/alimentary.

Aliases & Classifications for Duodenitis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

duodenitis 9 11 46
hemorrhagic duodenitis 9 63
acute enteritis of the mouse intestinal tract 63


External Ids:

Disease Ontology9 DOID:8643
MeSH36 D004382
SNOMED-CT59 155715004, 72007001
ICD9CM28 535.6
ICD1026 K29.8

Related Diseases for Duodenitis

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18GeneCards, 19GeneDecks
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Diseases related to Duodenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 492)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer31.9GAST, S100A8
2gastritis31.1GAST, S100A8
3gastric outlet obstruction30.9ATP4A, ATP12A, GAST
4dyspepsia30.8GAST, ATP12A, ATP4A
5gastrinoma30.8ATP4A, ATP12A, GAST
6gastric ulcer30.7GAST, S100A8
7esophagitis30.7ATP4A, ATP12A, IL5, S100A8, GAST
8adenoma30.7INS, S100A8, GAST
9hiatus hernia30.3ATP12A, ATP4A
10atrophic gastritis30.3S100A8, GAST
11insulinoma30.3GAST, INS
12peptic ulcer disease30.2GAST, S100A8, ATP12A, ATP4A
13diarrhea30.2GAST, INS, ATP12A, ATP4A
14bile reflux30.0ATP12A, ATP4A
15hypoglycemia30.0GAST, INS
16barrett's esophagus29.9GAST, S100A8
17gastroesophageal reflux disease29.9ATP4A, ATP12A, S100A8, GAST
18irritable bowel syndrome29.9ATP12A, ATP4A
19stomach cancer29.8ATP4A, ATP12A, GAST
20hyperinsulinemic hypoglycemia29.7INS, GAST
21laryngitis29.7ATP4A, ATP12A
22gastric adenocarcinoma29.7GAST, S100A8
23esophageal cancer29.6ATP12A, ATP4A
24bronchitis29.6S100A8, IL5
25achalasia29.6ATP4A, ATP12A, GAST
26asthma29.5ATP4A, ATP12A, IL5, S100A8
27duodenal obstruction11.1
28duodenal atresia10.9
29pancreatitis10.9
30annular pancreas10.6
31familial adenomatous polyposis10.6
32somatostatinoma10.5
33duodenal somatostatinoma10.5
34aneurysm10.5
35duodenal gastrinoma10.5
36acute pancreatitis10.5
37adenocarcinoma10.4
38aortic aneurysm10.4
39ileus10.4
40celiac disease10.4
41gastrointestinal stromal tumor10.4
42abdominal aortic aneurysm10.4
43gastroduodenitis10.4
44zollinger-ellison syndrome10.4
45situs inversus10.4
46blindness10.4
47chronic duodenal ileus10.4
48superior mesenteric artery syndrome10.4
49duodenal disease10.4
50giardiasis10.3

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to duodenitis

Symptoms for Duodenitis

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Drugs & Therapeutics for Duodenitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Duodenitis

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Genetic Tests for Duodenitis

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Anatomical Context for Duodenitis

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34MalaCards
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MalaCards organs/tissues related to Duodenitis:

34
Pancreas, Colon, Testes, Liver, T cells, Small intestine, Lymph node, Lung, Kidney, Thyroid, Breast, Heart, Bone, Endothelial, Pancreatic islet, B cells, Myeloid, Bone marrow, Ovary, Skin, Monocytes, Smooth muscle, Spleen, Pituitary

Animal Models for Duodenitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Duodenitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.3GAST, IL5, INS, ATP4A
2MP:00053817.6GAST, IL5, INS, ATP12A, ATP4A
3MP:00053767.4ATP4A, ATP12A, INS, IL5, GAST

Publications for Duodenitis

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53PubMed
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Articles related to Duodenitis:

(show top 50)    (show all 2561)
idTitleAuthorsYear
1
Acute segmentary ulcerative duodenitis induced by Streptococcus pyogenes mimicking inflammatory bowel disease. (23994254)
2013
2
Proximal duodenal obstruction--Bouveret's syndrome revisited. (23945924)
2013
3
Endoscopic submucosal dissection of a duodenal neuroendocrine tumor. (24368076)
2013
4
Acute mesenteric ischemia and duodenal ulcer perforation: a unique double pathology. (23110681)
2012
5
Association of genetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases. (23012664)
2012
6
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
7
Severe duodenal involvement in familial adenomatous polyposis treated by pylorus-preserving pancreaticoduodenectomy. (22311120)
2012
8
Isolated Russell body duodenitis. (21234686)
2011
9
Superior mesenteric artery syndrome: risk factor for duodenal involvement in Henoch-SchAPnlein purpura. (21129122)
2011
10
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. (21220246)
2011
11
An unusual case of ulcerative duodenitis. (21722640)
2011
12
Endoscopic ultrasound (EUS) aspect of duodenal bulb invasion by multifocal malignant pancreatic intraductal papillary mucinous neoplasm (IPMN). (21837609)
2011
13
Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. (20492663)
2010
14
Hemorrhagic gastritis and duodenitis following celiac plexus neurolysis. (19935986)
2009
15
Interleukin-1beta gene polymorphism as a predictor of eradication treatment efficacy in gastric and duodenal ulcer associated with Helicobacter pylori]. (19145908)
2008
16
High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. (17868414)
2007
17
Unexpected superimposition of nutcracker effect in various conditions: is it an unrecognized confounding factor? Comment on: Henoch-Schonlein purpura presenting duodenal involvement similar to superior mesenteric artery syndrome in a girl. (Eur J Pediatr. 2006 Sep 29; [Epub ahead of print]). (17180389)
2007
18
Duodenal switch operation for pathologic transpyloric duodenogastric reflux. (17245178)
2007
19
Pyloric obstruction, duodenal dilatation, and extrahepatic cholestasis: a neonatal triad suggesting multiple intestinal atresias. (17011287)
2006
20
Duodenal and gastric Dieulafoy's lesions in a patient with type 2A von Willebrand's disease. (15729257)
2005
21
A long-term survival case with multiple liver metastases from duodenal gastrointestinal stromal tumor that was drastically reduced by the treatment with imatinib]. (16315926)
2005
22
Duodeno-jejunal anastomosis with trans anastomotic nasojejunal tube for congenital duodenal obstruction. (15951892)
2005
23
Decreased epithelial cytokine responses in the duodenal mucosa of Helicobacter pylori-infected duodenal ulcer patients. (12522049)
2003
24
Embolization of a duodenal arteriovenous malformation in hereditary hemorrhagic telangiectasia: case report and review of the literature. (14631462)
2003
25
Different effect of antiulcer agents on rat cysteamine-induced duodenal ulcer after sialoadenectomy, but not gastrectomy. (14512101)
2003
26
Jejunoileal bypass changes the duodenal cholecystokinin and somatostatin cell density. (12935359)
2003
27
The sixth decision regarding perforated duodenal ulcer. (12500837)
2002
28
Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas. (11744604)
2002
29
Neonatal Boerhaave's syndrome with duodenal atresia. (12356229)
2002
30
14C urea breath test does not predict density of Helicobacter pylori in duodenal ulcer disease. (11558321)
2001
31
Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans. (10764704)
2000
32
Intraductal secretin test is as useful as duodenal secretin test in assessing exocrine pancreatic function. (9073129)
1997
33
Presence of the cagA gene in the majority of Helicobacter pylori strains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis. (9398887)
1996
34
Helicobacter pylori and duodenal ulcer: evidence for a histamine pathways-involving link. (8931414)
1996
35
Human giardiasis. A morphometric study of duodenal biopsy specimens in relation to the trophozoite count in the duodenal aspirate. (8080358)
1994
36
Paroxysmal nocturnal hemoglobinuria associated with venous thrombosis and papillary endothelial hyperplasia presenting as ulcerated duodenal mass. (8060237)
1994
37
Effect of duodenal switch procedure on gastric acid production, intragastric pH, gastric emptying, and gastrointestinal hormones. (1733373)
1992
38
Patients with duodenitis have gastric secretory and motor functions like those of duodenal ulcer patients: results of a short-term treatment with ranitidine. (2066545)
1991
39
Ceruloplasmin activity in blood serum in stomach and duodenal ulcers]. (1966196)
1990
40
Sarcoidosis causing duodenal obstruction. Case report and review of gastrointestinal manifestations. (2180656)
1990
41
Outcome of ulcer-associated duodenitis after short-term medical treatment. (4006645)
1985
42
Morphological aspects of duodenitis. (6962534)
1982
43
Value of serial sonography in the in utero detection of duodenal atresia. (7070738)
1982
44
Duodenal diaphragm associated with superior mesenteric artery syndrome. (7457748)
1981
45
Duodenal obstruction in the newborn. (5980964)
1966
46
A five-to ten-year follow-up study of the Billroth I and Billroth II (polya) operations for duodenal, gastric and gastrojejunal ulcer and gastroenterostomy with vagotomy in the treatment of duodenal ulcer. (13480410)
1957
47
Chronic duodenal ileus. (13185184)
1954
48
Duodenal obstruction in infants and children. (13079414)
1953
49
Complete duodenal obstruction in the newborn. (21020171)
1946
50
THE PRE- AND POSTOPERATIVE EMPLOYMENT OF A BRASSTIPPED GASTRODUODENAL TUBE AS AN AID IN THE SURGICAL TREATMENT OF DUODENAL OBSTRUCTION IN THE NEWBORN. (17858187)
1943

Variations for Duodenitis

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Expression for genes affiliated with Duodenitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for genes affiliated with Duodenitis

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51PathCards, 13EMD Millipore, 56Reactome, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Duodenitis

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 3BitterDB, 30IUPHAR, 25HMDB
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Compounds related to Duodenitis according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1calcium gluconate469.9INS, GAST
2i-app469.9GAST, INS
3methacholine46 52 1211.8IL5, GAST
44-ipp629.8IL5, S100A8
5git 27629.8IL5, S100A8
6starch469.8GAST, INS
7nicotinamide46 1210.8GAST, INS
8pirfenidone46 6210.8S100A8, IL5
9erythromycin46 3 52 1212.8GAST, IL5
10as 10146 6210.8S100A8, IL5
11octreotide46 62 30 1212.7INS, GAST
12amoxicillin46 52 1211.7S100A8, GAST
13c-peptide469.7GAST, INS
14metronidazole46 1210.7GAST, S100A8
15allergens469.6S100A8, IL5
16isoproterenol46 1210.5GAST, IL5
17esomeprazole46 52 1211.5ATP4A, GAST
18rabeprazole46 52 25 1212.5GAST, ATP4A
19hydrocortisone46 3 62 1212.5GAST, IL5, INS
20thyroxine46 2510.5GAST, IL5, INS
21lansoprazole46 52 25 1212.5ATP4A, GAST
22thalidomide46 52 62 1212.3S100A8, IL5
23tetracycline46 1210.3GAST, S100A8
24clarithromycin46 1210.3IL5, S100A8, GAST
25histamine46 30 2511.2IL5, S100A8, GAST
26testosterone46 62 25 1212.2INS, IL5, GAST
27creatinine469.1GAST, S100A8, INS
28pantoprazole46 52 25 1212.0GAST, ATP12A, ATP4A
29omeprazole46 52 30 25 1212.9GAST, S100A8, ATP4A
30dexamethasone46 52 30 1211.8INS, IL5, S100A8, GAST
31glutamate468.8INS, IL5, S100A8, GAST
32serine468.7INS, IL5, S100A8, GAST
33tyrosine468.6INS, IL5, S100A8, GAST
34alanine468.6INS, S100A8, GAST

GO Terms for genes affiliated with Duodenitis

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17Gene Ontology
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Cellular components related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5GAST, S100A8, IL5, INS
2extracellular spaceGO:0056157.9S100A8, IL5, INS, ATP4A

Biological processes related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1wound healingGO:0420609.4S100A8, INS
2positive regulation of NF-kappaB transcription factor activityGO:0510929.4S100A8, INS
3positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3IL5, INS
4positive regulation of cell growthGO:0303079.3INS, S100A8
5ATP biosynthetic processGO:0067549.2ATP12A, ATP4A

Molecular functions related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.5GAST, INS
2hydrogen:potassium-exchanging ATPase activityGO:0089008.8ATP12A, ATP4A

Products for genes affiliated with Duodenitis

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Sources for Duodenitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet