MCID: DDN006
MIFTS: 62

Duodenitis malady

Gastrointestinal diseases category

Summaries for Duodenitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Duodenitis is inflammation of the duodenum. It may persist acutely or chronically. more...

MalaCards: Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and gastric ulcer. An important gene associated with Duodenitis is CYBRD1 (cytochrome b reductase 1), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Mineral absorption. The compounds calcium and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and testes, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Duodenitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

duodenitis 8 10 44
hemorrhagic duodenitis 8 60
acute enteritis of the mouse intestinal tract 60


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Disease Ontology8 DOID:8643
ICD9CM27 535.6
SNOMED-CT56 155715004, 72007001
MeSH34 D004382
ICD1025 K29.8

Related Diseases for Duodenitis

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17GeneCards, 18GeneDecks
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Diseases related to Duodenitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 472)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer31.8HRH2, IL1RN, SST, GRP, DEFB4A, DEFB1
2gastric ulcer31.3HRH2, TFF1, GAST, S100A8
3pancreatitis31.3SST, SCT, CCK
4gastritis31.0S100A8, SCT, GAST, DEFB4A, IL1RN
5esophagitis30.8S100A8, GAST, HRH2
6somatostatinoma30.7SST, GAST
7dyspepsia30.7CCK, GAST, HRH2
8gastrinoma30.7SCTR, SCT, GAST, GRP, SST
9peptic ulcer30.7CCK, S100A8, SCT, GAST, HRH2, SST
10adenoma30.7S100A8, SCT, GAST, TFF1, SST
11acute pancreatitis30.6CCK, SCT, SST, IL1RN, HRH2
12adenocarcinoma30.6CCK, S100A8, PDX1, SCTR, SCT, GAST
13celiac disease30.5CCK
14zollinger-ellison syndrome30.5SCT, GAST, GRP, SST, HRH2
15pancreatic cancer30.5CCK, SCT, GAST, TFF1, SST
16gastroduodenitis30.5GAST
17duodenal neoplasm30.4S100G, SST
18duodenogastric reflux30.4CCK, GAST
19hepatitis30.4HRH2
20paraganglioma30.4GAST, GRP, SST
21obesity30.4CCK, GRP
22neuroendocrine tumor30.3SST
23ulcerative colitis30.2IL1RN, DEFB4A, DEFB1, TFF1
24insulinoma30.2PDX1, SCT, GAST, GRP, SST
25diarrhea30.2SST, GAST
26hemochromatosis30.2SLC40A1, CYBRD1
27atrophic gastritis30.1IL1RN, SST, TFF1, GAST, SCT, S100A8
28steatorrhea30.1SST, SCT, CCK
29alcoholic pancreatitis30.1CCK, SCT
30angiodysplasia30.1SST
31diabetes mellitus30.0SST, SCT, PDX1, CCK
32neuroendocrine carcinoma30.0SST, GRP, HDC, GAST
33sarcoidosis30.0IL1RN, GRP, DEFB4A, DEFB1
34bile reflux30.0TFF1, CCK
35hepatocellular carcinoma30.0S100A8, SCT, GRP
36stomach cancer29.9S100A8, GAST, TFF1, HDC, DEFB4A, GRP
37gastric adenocarcinoma29.9S100A8, GAST, TFF1, DEFB4A, GRP, IL1RN
38inflammatory bowel disease29.9S100A8, SCT, TFF1, DEFB1, DEFB4A, IL1RN
39gastroesophageal reflux disease29.9CCK, S100A8, SCT, GAST, HRH2
40cystic fibrosis29.9S100A8, SCTR, SCT, DEFB1, DEFB4A
41hypoglycemia29.9SST, GAST, SCT
42breast cancer29.9GRP, HDC, TFF1, S100A8
43islet cell tumor29.9GAST, SST
44hyperparathyroidism29.9SCT, GAST
45liver cirrhosis29.9SCT
46colorectal cancer29.8S100A8, GAST, TFF1, GRP, IL1RN
47wermer syndrome29.8SCT, GAST, SST
48barrett's esophagus29.8TFF1, GAST, S100A8
49irritable bowel syndrome29.8CCK
50arthritis29.8S100A8, IL1RN, HRH2

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to duodenitis

Clinical Features for Duodenitis

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Drugs & Therapeutics for Duodenitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Duodenitis

Search CenterWatch for Duodenitis

Genetic Tests for Duodenitis

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Anatomical Context for Duodenitis

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32MalaCards
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MalaCards organs/tissues related to Duodenitis:

32
Pancreas, Colon, Testes, Liver, T cells, Small intestine, Lymph node, Lung, Kidney, Thyroid, Breast, Heart, Bone, Endothelial, Pancreatic islet, B cells, Myeloid, Bone marrow, Ovary, Skin, Monocytes, Smooth muscle, Spleen, Pituitary

Animal Models for Duodenitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Duodenitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.8PTF1A, CCK, S100G, PDX1, SCTR, SCT
2MP:000538711.3SCTR, GAST, HDC, DEFB1, SST, IL1RN
3MP:000538110.9PDX1, GAST, TFF1, SST, HRH2, SLC40A1

Publications for Duodenitis

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50PubMed
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Articles related to Duodenitis:

(show top 50)    (show all 2591)
idTitleAuthorsYear
1
Acute segmentary ulcerative duodenitis induced by Streptococcus pyogenes mimicking inflammatory bowel disease. (23994254)
2013
2
Evolving duodenal atresia in a toddler. (22782320)
2013
3
Laparoscopic management of a large duodenal lipoma presented as gastric outlet obstruction. (24018087)
2013
4
Clinicopathologic features and prognosis of duodenal adenocarcinoma and comparison with ampullary and pancreatic ductal adenocarcinoma. (24139211)
2013
5
Duodenal-mucosal bacteria associated with celiac disease in children. (23835180)
2013
6
Endoscopic vs. laparoscopic gastrojejunostomy for duodenal obstruction: a randomized study in a porcine model. (22109650)
2012
7
dupA1 is associated with duodenal ulcer and high interleukin-8 secretion from the gastric mucosa. (22811495)
2012
8
Xanthogranulomatous cholecystitis presenting with duodenal ulcer and cholecystoenteric fistula. (22622751)
2012
9
A rare cause of intestinal obstruction in the adult: duodenal diaphragm. (23039811)
2012
10
Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: a multicenter, retrospective analysis in Japan. (21561531)
2011
11
Mortality in perforated duodenal ulcer depends upon pre-operative risk: a retrospective 10-year study. (20589448)
2010
12
In vitro digestibility of beta-casein and beta-lactoglobulin under simulated human gastric and duodenal conditions: a multi-laboratory evaluation. (19723552)
2009
13
Duodenal gastrinoma: a diagnostic dilemma. (19233342)
2009
14
Duodenal metastasis from male breast cancer: a case report and review of the literature. (19830225)
2009
15
FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients. (19702849)
2009
16
Congenital duodenal stenosis and annular pancreas: a delayed diagnosis in an adolescent patient with Down syndrome. (17043846)
2007
17
Laparoscopic closure of duodenal ulcer perforations. (17685968)
2007
18
Duodenal diazepam-binding protein expression and plasma cholecystokinin after alcoholic pancreatitis. (17101560)
2006
19
Frequency of small bowel polyps in patients with duodenal adenoma but without familial adenomatous polyposis. (16514568)
2006
20
Influence of cure of Helicobacter pylori infection on gastric acidity and gastroesophageal reflux: study by 24-h pH monitoring in patients with gastric or duodenal ulcer. (15870971)
2005
21
Ischemic duodenitis. (15657866)
2005
22
Detoxification enzymes in the duodenal mucosa of patients with familial adenomatous polyposis. (15856485)
2005
23
A "clean" technique for managing bleeding duodenal ulcer with a new aortic prosthesis: endoscopic-assisted repair of bleeding duodenal ulcer. (14571177)
2003
24
Duodenal gastric metaplasia, duodenal ulcer and Helicobacter pylori infection. (12546519)
2002
25
Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. (11247893)
2001
26
The effectiveness of one-week triple eradication therapy for perforated duodenal ulcer patients treated with simple closure. (11468454)
2001
27
Choledochal cyst associated with duodenal obstruction. (10945708)
2000
28
Effect of vagotomy on cholecystokinin release and gallbladder contraction in patients with complicated duodenal ulcer. (7851462)
1994
29
Pancreatic function and congenital duodenal anomalies. (8492257)
1993
30
Endoscopic balloon catheter removal of a rubber nipple causing complete duodenal obstruction. (8293916)
1993
31
Role of Helicobacter pylori in gastritis and duodenitis in man. (1442334)
1992
32
Ceruloplasmin activity in blood serum in stomach and duodenal ulcers]. (1966196)
1990
33
Duodenal obstruction by a nondeflating Foley catheter gastrostomy tube. (2122777)
1990
34
Low activities of disaccharidases associated with inflamed duodenal bulb mucosa. (2111272)
1990
35
Cardiac arrhythmias identified in horses with duodenitis/proximal jejunitis: six cases (1985-1988). (2243041)
1990
36
Duodenal osmolality drives gallbladder emptying in humans. (2344803)
1990
37
Duodenitis: a clinical, endoscopic and histopathologic study. (4059506)
1985
38
Pirenzepine in erosive duodenitis. A controlled clinical trial versus ranitidine. (3898351)
1985
39
Gastric outlet and duodenal obstruction from inflammatory pancreatic disease. (6732492)
1984
40
Value of serial sonography in the in utero detection of duodenal atresia. (7070738)
1982
41
Duodenogastric reflux in the fasting dog: role of pylorus and duodenal motility. (7270693)
1981
42
Duodenal obstruction caused by cystic masses. (4851456)
1974
43
Proceedings: The diagnosis of duodenitis. (4434975)
1974
44
Common duodenitis--of any clinical import? (4547161)
1974
45
Duodenal obstruction due to Hodgkin's disease of the lymph nodes at the porta hepatis. (5026231)
1972
46
Apple peel small bowel: an uncommon variant of duodenal and jejunal atresia. (5502887)
1970
47
NEONATAL DUODENAL OBSTRUCTION: THE INFLUENCE OF TREATMENT ON THE METABOLIC EFFECTS OF OPERATIONS. (14296770)
1965
48
Combined intrinsic duodenal obstruction and malrotation. (13757253)
1960
49
Arteriomesenteric duodenal obstruction. (13247687)
1955
50
Duodenal obstruction in the newborn with a description of four cases. (20266075)
1947

Genetic Variations for Duodenitis

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Expression for genes affiliated with Duodenitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for genes affiliated with Duodenitis

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Duodenitis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Duodenitis according to GeneCards/GeneDecks:

(show top 50)    (show all 115)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.1HRH2, S100A8, PDX1, SCTR, SCT, GAST
2retinoic acid44 2413.0PDX1, SCT, HRH2, TFF1, HDC, DEFB4A
3histamine44 28 2413.9IL1RN, CCK, GAST, SCT, HDC, DEFB4A
4glutamate4411.7IL1RN, SST, GRP, HDC, S100G, GAST
5adenylate4411.6SCT, SST, HRH2, CCK, IL1RN, GAST
6omeprazole44 28 49 11 2415.6CCK, SCT, GAST, HDC, SST, HRH2
7gaba4411.6GAST, CCK, S100G, GRP, SST, HDC
8acetylcholine44 49 28 11 2415.5SCTR, CCK, SCT, GAST, GRP, SST
9atropine44 28 1113.5GRP, GAST, SST, CCK, HRH2, SCT
10dexamethasone44 49 28 1114.4DEFB1, DEFB4A, CCK, GRP, TFF1, S100A8
11acth4411.4IL1RN, SST, GRP, GAST, SCT, CCK
12loxiglumide4411.4SST, GAST, SCT, CCK, GRP
13pepsinogen4411.4SCT, GAST, GRP, HRH2, CCK
14rantes4411.4IL1RN, DEFB4A, DEFB1, HDC, S100A8, SCT
15pirenzepine44 28 1113.4CCK, HRH2, GRP, GAST, SST
16oxyntomodulin44 5912.4CCK, GAST, SST, GRP, SCT
17epinephrine44 11 2413.4SCT, GAST, SST, HRH2, GRP, IL1RN
18testosterone44 59 11 2414.4IL1RN, GRP, CCK, SCT, GAST, TFF1
19octreotide44 59 28 1114.3SCT, GAST, GRP, SST, CCK
20c-peptide4411.3SST, SCT, CCK, PDX1, GAST
21bicarbonate4411.3SCT, SCTR, CCK, HRH2, GAST
22norepinephrine44 11 2413.3GAST, IL1RN, SCT, CCK, SST, GRP
23lafutidine4411.3SST, HRH2, GAST, SCT
24minigastrin4411.3GRP, GAST, CCK, SST
25bethanechol44 28 1113.3GRP, SST, GAST, CCK
26amoxicillin44 49 1113.3GAST, S100A8, IL1RN, HRH2
27ibmx44 28 5913.2SCT, TFF1, GRP, SST, CCK
28dtpa4411.2SST, CCK, GRP, GAST
29clarithromycin44 1112.2GAST, IL1RN, HRH2, S100A8
30carbachol44 28 1113.2CCK, SCT, GAST, GRP, SST
31ranitidine44 28 11 2414.2HRH2, GAST, SCT, CCK
325-hydroxytryptamine4411.2SST, HRH2, GRP, CCK, GAST
33isoproterenol44 1112.2HRH2, SCT, GRP, GAST, SST
34taurodeoxycholate4411.1SCT, SST, CCK
35l-bpa4411.1SCTR, SCT, CCK
36caerulein4411.1CCK, GRP, SCT
37pancreozymin4411.1GAST, SCT, CCK
38pge24411.1SST, GRP
39enprostil28 4412.1HRH2, SST, GAST
40cerulein4411.1CCK, SCT, GRP
41peptone4411.1GAST, GRP, CCK
42tetrodotoxin44 59 2813.0HRH2, GRP, CCK, SCT
43aspirin44 49 28 2414.0TFF1, CCK, HRH2, IL1RN, GRP
44neomycin4411.0CCK, GAST, GRP, PDX1
45propranolol44 28 49 11 2415.0SCT, SST, GAST, GRP
46pantoprazole44 49 11 2414.0SST, GAST, HRH2
47domperidone44 28 1112.8HRH2, GAST, SST
48lansoprazole49 44 11 2413.8HRH2, GAST, IL1RN
49amide4410.7HDC, GAST, S100G, CCK
50dopamine44 28 11 2413.7GAST, SST, GRP, HDC, SCT, CCK

GO Terms for genes affiliated with Duodenitis

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16Gene Ontology
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Cellular components related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.0IL1RN, SST, GRP, TFF1, S100A8, CCK
2extracellular regionGO:00557610.9SST, CCK, S100A8, SCT, GAST, DEFB1

Biological processes related to Duodenitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718611.2SST, DEFB4A, DEFB1, GAST, SCTR
2endocrine pancreas developmentGO:03101810.9PDX1, PTF1A, RFX6
3digestionGO:00758610.9SST, TFF1, SCTR
4cellular iron ion homeostasisGO:00687910.9CYBRD1, SLC46A1, SLC40A1
5type B pancreatic cell differentiationGO:00330910.9RFX6, PDX1
6immune responseGO:00695510.9HRH2, IL1RN, DEFB4A, DEFB1
7exocrine pancreas developmentGO:03101710.7PTF1A, PDX1
8response to iron ionGO:01003910.7CYBRD1, TFF1
9acute inflammatory responseGO:00252610.6DEFB1, S100A8
10defense response to bacteriumGO:04274210.5S100A8, DEFB1, DEFB4A

Molecular functions related to Duodenitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.9SST, GAST, SCT, CCK

Products for genes affiliated with Duodenitis

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Sources for Duodenitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet