Duodenitis malady

Wikipedia: Duodenitis is inflammation of the duodenum. It may persist acutely or chronically.⁴⁴ more...

MalaCards: Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and peptic ulcer. An important gene associated with Duodenitis is CYBRD1 (cytochrome b reductase 1), and among its related pathways are Rheumatoid arthritis and Cytokine production by Th17 cells in CF (Mouse model). The compounds pge2 and cyclic amp have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, small intestine and colon, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Aliases & Descriptions:

duodenitis 6 8 32 hemorrhagic duodenitis 6 43

acute enteritis of the mouse intestinal tract 43

Diseases related to duodenitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 954)

id	Related Disease	Score	Top Affiliating Genes
1	duodenal ulcer	39.4	SCT, S100A8, GRP, IL1RN, HRH2, GAST
2	peptic ulcer	34.3	GCG, SCT, UGT1A6, MUC5AC, S100A8, XDH
3	gastrinoma	34.0	GCG, VIP, SCTR, SCT, CHGA, CDKN2A
4	somatostatinoma	33.7	GCG, VIP, CHGA, MEN1, ENO2, CALCA
5	gastritis	33.4	SCT, S100A8, CDX2, MLH1, MGMT, GSTT1
6	pancreatitis	32.8	PIK3CG, RFX6, REG3A, SGK1, KIT, KITLG
7	dyspepsia	32.7	S100A8, CD79A, CD14, MLN, MIF, GRP
8	gastroduodenitis	31.9	GCG, SERPINA6, SCT, CHGA, MUC1, MUC2
9	celiac disease	31.8	VDR, SCG5, SCT, LEP, MUC2, MUC5AC
10	atrophic gastritis	31.7	SCT, CHGA, S100A8, XDH, CDX2, MEN1
11	hemochromatosis	31.7	MT-CYB, B2M, IREB2, CALR, HLA-B, CYBRD1
12	multiple endocrine neoplasia	31.5	GCG, VIP, SCT, CHGA, CDKN2A, CDH1
13	pancreatic cancer	31.2	GCG, VIP, SCT, LGALS3, CHGA, MUC1
14	zollinger-ellison syndrome	30.8	SCT, CHGA, CDH1, MLN, MEN1, GRP
15	alcoholism	30.6	SCT, CFTR, GSR, IL1RN, MAOB, CCKBR
16	paraganglioma	30.4	KIT, PCNA, VIP, BCL2, LGALS3, CHGA
17	dermatitis herpetiformis	30.4	CD79A, CD40LG, MMP12, MMP3, MMP7, IL2RB
18	insulinoma	30.4	PIK3CG, REG3A, PC, GCK, GCG, VIP
19	carcinoma	30.3	PIK3CG, REG3A, KIT, KITLG, PCNA, GCK
20	familial adenomatous polyposis	30.2	PCNA, BRAF, RARB, CLIP1, UGT1A1, UGT1A10
21	gastric cancer	30.1	PIK3CG, REG3A, KIT, PCNA, GCG, BRAF
22	gastric ulcer	29.6	PCNA, MUC5AC, S100A8, MPO, MMP3, MMP7
23	neuroendocrine tumor	29.3	GCG, VIP, MYCN, SCT, CHGA, CEACAM3
24	iron overload	29.1	VDR, UGT1A1, XDH, B2M, IREB2, INS
25	ankylosing spondylitis	28.9	CD79A, CD40LG, MMP3, IL17A, IL1RN, HLA-B
26	acquired immunodeficiency syndrome	28.9	GCG, MT-CYB, B3GAT1, XDH, B2M, CETP
27	crohn's disease	28.8	GCG, MUC2, MPO, FOXP3, MLN, MIF
28	arthritis	28.8	VIP, MMP3, IL17A, IL1A, IL1B, IL6
29	exocrine pancreatic insufficiency	28.8	CLPS, SCT, CFTR, CEL, CD79A, CCK
30	paroxysmal nocturnal hemoglobinuria	28.7	CD14, CD59, CD55, HLA-A, HLA-B, HLA-DQA1
31	hemoglobinuria	28.7	CD14, CD59, CD55, HLA-A, HLA-B, HLA-DQA1
32	neurofibromatosis	28.6	KIT, KITLG, MSH2, MSH6, MLH1, MEN1
33	dermatitis	28.5	KITLG, VIP, CMA1, BCL2, LGALS3, LEP
34	polyposis	28.4	PIK3CG, KITLG, PCNA, VIP, BRAF, VDR
35	candidiasis	28.4	MT-CYB, B2M, MPO, CD79A, CD40LG, MIF
36	hepatitis	28.4	XDH, GSR, IL2RB, FAS, GPT, ALB
37	parkinson's disease	28.1	MT-CYB, S100G, IREB2, GSR, MAOB, CCKBR
38	gastroesophageal reflux disease	28.0	GCG, BCL2, SCT, S100A8, CDX2, CDH1
39	immunodeficiency	28.0	VIP, CLIP1, CD79A, CD40LG, CD55, FOXP3
40	morbid obesity	27.8	GCG, LPL, LEP, INS, FABP2, CCK
41	epidermolysis bullosa	27.8	MUC1, CD79A, CDKN2A, ITGA6, MMP3, FGF2
42	cystic fibrosis	27.8	PIK3CG, REG3A, SGK1, PCNA, VIP, LPL
43	psoriatic arthritis	27.8	S100A8, CD79A, CD59, CD40LG, MMP3, MMP9
44	alcoholic pancreatitis	27.6	REG3A, LPL, LIPF, SCT, XDH, CFTR
45	squamous cell carcinoma	27.6	LGALS3, CDH1, MMP12, MMP7, MKI67, GSTP1
46	irritable bowel syndrome	27.6	GCG, VIP, LEP, CHGA, MPO, CD79A
47	thrombosis	27.3	PIK3CG, PCNA, LEP, CHGA, MUC1, XDH
48	diabetic ketoacidosis	27.3	INS, IL10, IL6, ALB, HSPA1A, CALCA
49	primary hyperparathyroidism	27.2	KITLG, VDR, LEP, CHGA, B2M, CFTR
50	cholelithiasis	27.1	VIP, CHGA, UGT1A1, UGT1A6, UGT2B4, MUC2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to duodenitis:

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MGI Mouse Phenotypes related to duodenitis:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	11.9	RFX6, PASK, SCG5, LALBA, XDH, AXIN2
2	immune system phenotype	MP:0005387	11.5	KIT, SERPINA6, BRAF, VDR, CMA1, SCG5
3	liver/biliary system phenotype	MP:0005370	11.4	KIT, GCK, SERPINA6, LPL, MYCN, PASK
4	craniofacial phenotype	MP:0005382	11.2	KIT, KITLG, MYCN, CLPS, AXIN2, CFTR
5	digestive/alimentary phenotype	MP:0005381	11.1	RFX6, KIT, KITLG, GCG, BRAF, VDR
6	respiratory system phenotype	MP:0005388	11.0	LPL, MYCN, PASK, SCG5, CFTR, CDON
7	nervous system phenotype	MP:0003631	10.9	KIT, KITLG, BRAF, MYCN, PASK, SCG5
8	hematopoietic system phenotype	MP:0005397	10.6	KIT, PCNA, BRAF, MYCN, BCL2, SCTR
9	embryogenesis phenotype	MP:0005380	10.4	KIT, BRAF, MYCN, RARB, AXIN2, CDX2
10	reproductive system phenotype	MP:0005389	10.4	VIP, VDR, MYCN, RARB, PASK, LEP
11	other phenotype	MP:0005395	10.3	RARB, CDKN2A, CD40LG, ITGA6, ESR2, PTGER2
12	renal/urinary system phenotype	MP:0005367	10.1	SGK1, KIT, GCK, SERPINA6, BRAF, MYCN
13	behavior/neurological phenotype	MP:0005386	10.0	RFX6, KIT, SERPINA6, VIP, BRAF, MYCN
14	growth/size phenotype	MP:0005378	9.8	PIK3CG, RFX6, SGK1, KIT, KITLG, GCK
15	mortality/aging	MP:0010768	9.6	RFX6, KITLG, GCK, GCG, BRAF, LPL
16	integument phenotype	MP:0010771	9.6	PIK3CG, KIT, KITLG, BRAF, CLPS, BCL2
17	skeleton phenotype	MP:0005390	9.2	PIK3CG, KIT, KITLG, BRAF, VDR, MYCN
18	no phenotypic analysis	MP:0003012	9.1	SGK1, PCNA, SERPINA6, MUC1, CEBPB, CD79A
19	normal phenotype	MP:0002873	9.1	VIP, BRAF, RARB, LALBA, S100G, AXIN2
20	limbs/digits/tail phenotype	MP:0005371	8.7	KIT, KITLG, VDR, MYCN, RARB, LEP
21	adipose tissue phenotype	MP:0005375	8.6	BRAF, LPL, CLPS, BCL2, SCG5, LEP
22	cellular phenotype	MP:0005384	8.0	PIK3CG, KIT, KITLG, PCNA, BRAF, VDR
23	vision/eye phenotype	MP:0005391	7.9	KIT, KITLG, BRAF, MYCN, RARB, BCL2
24	homeostasis/metabolism phenotype	MP:0005376	7.6	PIK3CG, REG3A, SGK1, KIT, KITLG, GCK
25	muscle phenotype	MP:0005369	7.3	PIK3CG, KIT, BRAF, LPL, MYCN, RARB
26	cardiovascular system phenotype	MP:0005385	7.3	PIK3CG, KIT, KITLG, BRAF, LPL, VDR
27	tumorigenesis	MP:0002006	6.8	KIT, KITLG, BRAF, BCL2, LEP, MUC1

Articles related to duodenitis:

(show top 50)    (show all 504)

id	Title	Authors	Year	Affiliating Genes
1	In vitro digestibility of beta-casein and beta-lactog lobulin under simulated human gastric and duodenal conditions: a multi-laborato ry evaluation. (19723552)	Mandalari G.... Mills E.N.	2009	CSN2
2	Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patients. (19426392)	Jafarzadeh A.... Rezayati M.T.	2009	IL17A, IL23A
3	Sonic hedgehog and pancreatic-duodenal homeobox 1 exp ression distinguish between duodenal and pancreatic gastrinomas. (19240184)	Fendrich V.... Rothmund M.	2009	SHH, PDX1
4	Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (18809506)	Moura S.B.... Magalhaes Queiroz D.M.	2008	TLR2, TLR4, TLR5
5	Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (18161889)	Berkhout M.... Peters W.H.	2008	GSTP1, GSTT1, GSTM1
6	Full length ryanodine receptor subtype 3 encodes spontaneous calcium oscillations in native duodenal smooth muscle cells. (18207571)	Dabertrand F.... Morel J.L.	2008	RYR2, RYR3
7	Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions. (17135306)	Anlauf M.... Kloppel G.	2007	MEN1
8	Novel association of duodenal gastrinoma and atrophic gastritis: case report and literature review. (18194935)	Lendel I.... Ruggiero F.M.	2007	CCKBR, MEN1
9	CD1-restricted recognition of exogenous and self-lipid antigens by duodenal gammadelta+ T lymphocytes. (17339459)	Russano A.M.... Spinozzi F.	2007	IL4
10	Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. (18001398)	Arachchi H.S.... Ahuja V.	2007	S100A8
11	Correlation of duodenal histology with tissue transglutaminase and endomysial antibody levels in pediatric celiac disease. (17428743)	Donaldson M.R.... Book L.S.	2007	CD79A
12	Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese. (16543737)	Ueda H.... Chayama K.	2006	S100A8
13	Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer. (16550552)	Chakravorty M.... Roychoudhury S.	2006	IL1B, IL1RN
14	Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2. (16217040)	Leppilampi M.... SjAPblom M.	2005	CA2
15	The interleukin-1 RN polymorphism and Helicobacter pylori infection in the development of duodenal ulcer. (15610073)	Hsu P.I.... Chen A.	2004	IL1B, IL1RN
16	Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. (12949720)	Zoller H.... Weiss G.	2003	SLC11A2, SLC40A1, HFE
17	Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis. (14677189)	Lamarque D.... Claudepierre P.	2003	NOS2
18	Therapeutic tactics for treating patient with duodenal ulcer complicated my hemorrhage (12664778)	Baskhaeva R.G.	2003	HRH2
19	Effect of quamatel on neutrophil properties, parameters of lipid peroxidation and the antioxidant defense system in blood of patients with duodenal ulcer and pancreatitis (14743716)	Artiukhov V.G.... Basharina O.V.	2003	SOD1, GSR
20	Lack of association between pro-inflammatory genotypes of the interleukin-1 (IL-1B -31 C/+ and IL-1RN *2/*2) and gastric cancer/duodenal ulcer in Korean population. (12788304)	Lee S.G.... Song K.	2003	IL1B, IL1RN
21	The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol. (12426521)	Siegmund W.... Cascorbi I.	2002	ABCB1, ABCB11
22	Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin. (12404236)	Feurle G.E.... Weihe E.	2002	COPA
23	Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. (11533074)	Barshack I.... Kopolovic J.	2001	CDH1
24	Comparative study of the action of bovine duodenal proteinases (duodenases) on polypeptide substrates. (11240394)	Sokolova E.A.... Zamolodchikova T.S.	2001	CTRL
25	Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans. (10764704)	Schirra J.... Katschinski M.	2000	GCG
26	Gastric metaplasia in the duodenal bulb shows increased mucosal interleukin-8 activity in Helicobacter pylori-positive duodenal ulcer patients. (10868450)	Noshiro M.... Nishio Y.	2000	IL8
27	Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis. (10833480)	Pratha V.S.... Isenberg J.I.	2000	CFTR
28	A rare case of multiple carcinoids and endocrine cell micronests in a patient with chronic duodenitis. (10964325)	Abe H.... Makuuchi M.	2000	GAST
29	Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers. (9922305)	Hamlet A.... Olbe L.	1999	S100A8
30	Effect of chronic duodenal ulceration and its treatme nt with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover a nd TGF-alpha, bFGF, and EGF receptor expression in humans. (9881512)	Zhang T.... Ogden J.	1998	FGF2, TGFA
31	False-positive gliadin and endomysium antibodies and exocrine pancreatic insufficiency as pitfalls in the differential diagnosis of duodenal Crohn's versus celiac disease. (9672361)	Weber P.... Harms E.	1998	CD79A
32	Mucosal expression and luminal release of epidermal and transforming growth factors in patients with duodenal ulcer before and after eradication of Helicobacter pylori. (9176072)	Konturek P.C.... Hahn E.G.	1997	EGF, TGFA, TGIF1
33	Impaired fibrinolysis and increased protease levels i n gastric and duodenal mucosa of patients with active duodenal ulcer. (9149198)	HerszA"nyi L.... Farinati F.	1997	CTSB
34	Duodenal content reflux esophagitis in the rat: an animal model for the ulcer-associated cell lineage (UACL)? (9403733)	Hanby A.M.... Poulsom R.	1997	TFF2
35	Histamine inhibits prostaglandin E2-stimulated rabbit duodenal bicarbonate secretion via H2 receptors and enteric nerves. (7768371)	Hogan D.L.... Isenberg J.I.	1995	HRH2
36	Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients. (7489932)	Konturek J.W.... Domschke W.	1995	CCKAR, SST, CCK
37	Aberrant insulinoma of the duodenal bulb. (8581156)	Watanabe W.... Tsutsumi Y.	1995	CST3, CHGA, B3GAT1
38	Changes in gastric acid secretion and fasting gastrin levels during healing of duodenal ulcers. (8797269)	Hasebe T.... Miwa T.	1995	GAST
39	Multiple endocrine neoplasia type 1 presenting as insulinoma, gastrinoma, and postbulbar duodenal ulcers: report of a case. (8555708)	Murakami S.... Miura S.	1995	GAST
40	Von Recklinghausen's disease associated with duodenal somatostatinoma: contrast of duodenal versus pancreatic somatostatinomas. (7745981)	Mao C.... Howard J.M.	1995	SST
41	The gastrin and pepsinogen levels of patients with chronic atrophic gastritis and duodenal ulcer (8191737)	Valenkevich L.N.	1993	GAST
42	Rationale for eradication of Helicobacter pylori infection in duodenal ulcer disease. (8205594)	Malfertheiner P.... DomA-nguez-MuA+oz J.E.	1993	GAST
43	Characteristics of teen-age patients with juvenile duodenal ulcer. Relation between inherited hyperpepsinogenemia I and duodenal ulcer. (8430271)	Kimura M.... Kajiyama G.	1993	GAST
44	Effect of highly selective vagotomy on gastric emptyi ng, gastric acid secretion, and gastrin release: an early postoperative study i n duodenal ulcer patients. (7940604)	Lukasiewicz S.... Jonderko K.	1993	GAST
45	An experimental study of adrenalin-stimulated gastric acid secretion and gastrin secretion in rats of cysteamine-induced duodenal ulcer (1578802)	Koga S.... Aoki T.	1992	GAST
46	Prospective study of the use of intraarterial secretin injection and portal venous sampling to localize duodenal gastrinomas. (1455303)	Thom A.K.... Jensen R.T.	1992	SCT
47	Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. (1612474)	Beardshall K.... Calam J.	1992	GRP, GAST
48	Effect of duodenal ulcer healing induced by omeprazole and ranitidine on the generation of gastroduodenal eicosanoids, platelet-activating factor, pepsinogen A, and gastrin in duodenal ulcer patients. (1736336)	Lysy J.... Rachmilewitz D.	1992	GAST
49	Cellular and humoral immunity in duodenal peptic ulc er with gastrin cell hyperplasia (2392746)	Zverkov I.V.... MaslovskiA- L.V.	1990	GAST
50	Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis. (2179037)	Lombard M.... Williams R.	1990	TFRC

Genes related to duodenitis according to GeneCards:

(show top 50)    (show all 295)

id	Symbol	Description	Score	GeneCards Section Context
1	CYBRD1	cytochrome b reductase 1	11.1	Aliases & Descriptions, Summaries, Functions, Publications
2	PDX1	pancreatic and duodenal homeobox 1	11.0	Orthologs, Publications, Aliases & Descriptions, Transcripts
3	SLC40A1	solute carrier family 40 (iron-regulated transporter), member 1	11.0	Functions, Publications, Summaries
4	S100G	S100 calcium binding protein G	11.0	Summaries, Publications
5	PTF1A	pancreas specific transcription factor, 1a	11.0	Summaries, Functions
6	SLC46A1	solute carrier family 46 (folate transporter), member 1	11.0	Functions, Summaries
7	RFX6	regulatory factor X, 6	11.0	Summaries
8	SCTR	secretin receptor	11.0	Summaries
9	GAST	gastrin	11.0	Publications
10	SCT	secretin	11.0	Publications
11	S100A8	S100 calcium binding protein A8	11.0	Publications
12	SST	somatostatin	11.0	Publications
13	HRH2	histamine receptor H2	11.0	Publications
14	GRP	gastrin-releasing peptide	11.0	Publications
15	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
16	CCK	cholecystokinin	11.0	Publications
17	MUC6	mucin 6, oligomeric mucus/gel-forming	11.0	Expressions, Publications
18	TFF1	trefoil factor 1	11.0	Publications
19	HDC	histidine decarboxylase	11.0
20	DEFB1	defensin, beta 1	11.0
21	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0
22	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
23	DEFB4A	defensin, beta 4A	11.0
24	TGIF1	TGFB-induced factor homeobox 1	11.0	Publications
25	TLR2	toll-like receptor 2	11.0	Publications
26	GSR	glutathione reductase	11.0	Publications
27	IL8	interleukin 8	11.0	Publications
28	CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	11.0	Publications
29	PGA3	pepsinogen 3, group I (pepsinogen A)	11.0	Publications
30	HSPA1L	heat shock 70kDa protein 1-like	11.0	Publications
31	PGC	progastricsin (pepsinogen C)	11.0	Publications
32	CCKAR	cholecystokinin A receptor	11.0	Publications
33	HNMT	histamine N-methyltransferase	11.0	Publications
34	MEN1	multiple endocrine neoplasia I	11.0	Publications
35	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
36	IL23A	interleukin 23, alpha subunit p19	11.0	Publications
37	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
38	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
39	SCG5	secretogranin V (7B2 protein)	11.0
40	TLR5	toll-like receptor 5	11.0	Publications
41	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
42	CCKBR	cholecystokinin B receptor	11.0	Publications
43	CDON	Cdon homolog (mouse)	11.0
44	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0
45	HSPA1B	heat shock 70kDa protein 1B	11.0	Publications
46	NOD1	nucleotide-binding oligomerization domain containing 1	11.0	Publications
47	SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	11.0	Publications
48	EGR1	early growth response 1	11.0	Publications
49	IL17A	interleukin 17A	11.0	Publications
50	HSPA1A	heat shock 70kDa protein 1A	11.0	Publications

Pathways related to duodenitis according to GeneDecks:

(show top 50)    (show all 111)

id	Pathway	Score	Top Affiliating Genes
1	Rheumatoid arthritis20	12.0	IL23A, CSF2, CXCL1, IL6, IL8, CCL5
2	Cytokine production by Th17 cells in CF (Mouse model)41	11.6	TGFB1, TGFBR2, CXCL1, CSF2, IL6, TLR4
3	Influenza A20	11.6	IL6, CYCS, PLG, TLR4, IL1B, IL1A
4	G alpha (q) signalling events38	11.5	GRPR, GAST, NMB, HCRTR2, HCRTR1, EDN1
5	Antigen processing and presentation20	11.5	HSPA1A, HSPA1B, HSPA1L, HSPA4, HLA-DQB1, CTSB
6	Bacterial infections in CF airways41	11.4	DEFB4A, CFTR, TLR2, TLR5, MUC1, CTSB
7	Type I diabetes mellitus20	11.1	HLA-DQB1, HLA-DQA1, TNF, LTA, HLA-DMB, HLA-DMA
8	Retinol metabolism20	11.0	UGT1A3, CYP3A5, UGT1A4, UGT1A6, UGT2B15, UGT2B4
9	Graft-versus-host disease20	10.9	IL1A, HLA-DQA1, HLA-A, HLA-B, HLA-DMA, HLA-DMB
10	Metabolism of xenobiotics by cytochrome P45020	10.9	GSTA1, CYP3A5, UGT2B4, UGT2B15, UGT1A6, UGT1A4
11	Drug metabolism - other enzymes20	10.8	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT2B15
12	Drug metabolism - cytochrome P45020	10.8	UGT1A1, UGT1A10, UGT1A3, UGT1A4, CYP3A5, CYP2C19
13	Colorectal Cancer Metastasis36	10.8	AXIN2, PTGER4, CTNNB1, EGF, TLR2, TLR4
14	Immune response MIF in innate immunity response10	10.8	TP53, TNF, TLR4, NOS2, PTGS2, IL6
15	Metabolic pathways20	10.8	MT-CYB, GCK, LIPF, UGT1A1, UGT1A3, UGT2B7
16	Immune response_MIF in innate immunity response41	10.8	IL8, MAPK11, TLR4, TNF, IL6, IL1B
17	Leishmaniasis20	10.7	IL10, TGFB1, TLR2, NOS2, PTGS2, TNF
18	Colorectal cancer20	10.7	TGFB1, TGFBR2, MSH2, MSH6, AXIN2, BRAF
19	Toxoplasmosis20	10.6	CYCS, NOS2, TLR4, TGFB1, TLR2, TNF
20	Asthma20	10.5	HLA-DMA, HLA-DQA1, RNASE3, TNF, IL4, CD40LG
21	Allograft rejection20	10.5	HLA-DQB1, HLA-DRB1, HLA-DQA1, FAS, TNF, HLA-DMA
22	Intestinal immune network for IgA production20	10.5	IL4, IL5, IL6, MADCAM1, HLA-DMA, IL10
23	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	10.4	VDR, CYP27B1, CYP3A4, CALCA, CDX2, TNF
24	Tuberculosis20	10.4	TNF, HLA-DRB1, HLA-DQB1, CYCS, CYP27B1, NOS2
25	Hematopoietic cell lineage20	10.3	KITLG, TNF, CSF2, TFRC, HLA-DRB1, IL6
26	Transcription Role of VDR in regulation of genes involved in osteoporosis10	10.3	CALR, CALB1, CDX2, IGF1, IL6, IL1B
27	Cytokine-cytokine receptor interaction20	10.3	IL1A, IL17A, IL10, IL1B, CD40LG, TGFB1
28	Akt Signaling36	10.3	EPHA3, CSF2, CXCL1, TIMP3, LTA, NRAS
29	MIF Regulation of Innate Immune Cells36	10.3	PTGS2, BCL2, MIF, IL4, CSF2, TLR4
30	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	10.3	CAT, ABCB1, ABCC1, ABCC2, NOS3, SOD1
31	MIF Mediated Glucocorticoid Regulation36	10.2	LTA, TLR4, TNF, CXCL1, MIF, CD14
32	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	10.2	GSTP1, GSTT1, VDR, PTGS2, PTGS1, CYP3A4
33	IL-10 Pathway36	10.2	MAPK11, CD14, IL10, HMOX1, TNF, IL6
34	Chagas disease (American trypanosomiasis)20	10.1	IL6, TGFB1, TGFBR2, IL10, IL1B, PIK3CG
35	Molecular Mechanisms of Cancer36	10.1	CXCL1, PRKDC, TGFBR2, TGFA, TIMP3, TIMP2
36	Autoimmune thyroid disease20	9.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DMB, HLA-B, HLA-DMA
37	Endothelin-1 Signaling Pathway36	9.9	IL1B, NRAS, EPHA3, CXCL1, IL10, NTRK3
38	MAPK Family Pathway36	9.7	TIMP1, EGF, LTA, IL5, KITLG, TNF
39	Tec Kinases Signaling36	9.7	IL6, IL4, IL2RB, IL23A, IL5, IL1B
40	TGF-Beta Pathway36	9.6	TGFBR2, CDH1, FGF2, IL10, IL1A, IL1B
41	ERK Signaling36	9.5	EPHA3, NTRK3, CCL5, CXCL1, IL23A, ESR2
42	Endometrial cancer20	9.4	KRAS, NRAS, CTNNB1, TP53, CCND1, APC
43	Antioxidant Action of Vitamin-C36	9.4	IL5, FGF2, IL1A, SLC2A2, CSF2, IL1B
44	PAK Pathway36	9.4	BCL2, CSF2, CXCL1, IL5, TGFA, IL8
45	all-trans-Retinoic Acid Signaling in Brain36	9.4	IL6, IL8, CCL5, TNF, PTGS2, LTA
46	Pancreatic Adenocarcinoma36	9.3	TIMP3, TGFB1, TGFA, TIMP2, TIMP1, EGF
47	JAK-STAT Pathway36	9.2	KIT, NTRK3, NRAS, EGF, TIMP1, TIMP2
48	p38 Signaling36	9.2	NTRK3, IL5, IL2RB, IL23A, IL1A, IL10
49	Pathways in cancer20	9.0	CYCS, TP53, CCND1, FAS, FGF2, GSTP1
50	Rho Family GTPases36	9.0	IL4, IL23A, IL1B, IL1A, FGF2, ITGA6

Compounds related to duodenitis according to GeneDecks:

(show top 50)    (show all 591)

id	Compound	Score	Top Affiliating Genes
1	pge232	11.8	VIP, SCT, MUC5AC, CFTR, CD14, CDH1
2	cyclic amp32 18	12.7	SGK1, GCG, BRAF, RARB, SCTR, SCT
3	carbachol32 9 9	13.5	GCG, SCT, CFTR, GRP, CCK, SST
4	acth32	11.2	SERPINA6, VIP, SCG5, SCT, LGALS3, LEP
5	tetrodotoxin32	11.2	GCG, VIP, SCT, MLN, GRP, MBP
6	l-nmma32	11.1	VIP, XDH, IL1RN, CCK, IGHE, CAT
7	sialic acid32	11.1	SERPINA6, MUC2, MUC5AC, CEL, CD79A, CD59
8	bromodeoxyuridine32	11.1	KITLG, PCNA, MYCN, CHGA, MLH1, MKI67
9	amine32	11.0	SCT, CHGA, UGT1A, UGT1A1, UGT1A3, UGT1A4
10	12-o-tetradecanoylphorbol 13-acetate32	11.0	BRAF, RARB, MUC2, CEBPB, CDH1, MMP3
11	gaba32 42	11.9	GCG, VIP, SCT, CHGA, S100G, GSR
12	cyclophosphamide32 34 9 9	13.9	MBL2, LTF
13	morphine32 9 9	12.9	VIP, UGT1A, UGT1A1, UGT1A3, UGT1A4, UGT1A6
14	isoproterenol32 9 9	12.8	GCG, BRAF, SCT, CHGA, CFTR, GUCA2A
15	arachidonic acid32 9 18 9	13.7	KITLG, LPL, LIPF, UGT1A1, S100A8, CEL
16	egcg32	10.7	PIK3CG, UGT1A, UGT1A1, IL1A, CCL5, CAT
17	octreotide32 42 9 9	13.6	GCG, VIP, SCT, CHGA, MPO, MLN
18	tgf beta132	10.5	KITLG, CDH1, MMP3, FOXP3, MKI67, FGF2
19	dmso32	10.5	KITLG, CHGA, UGT1A, UGT1A6, MUC5AC, XDH
20	trifluoperazine32 9 9	12.5	UGT1A, UGT1A1, UGT1A4, UGT1A6, UGT2B7, XDH
21	sp 60012532 42	11.5	PIK3CG, IL17A, TP53, CYCS, TLR2, DEFB4A
22	glibenclamide32 34	11.4	GCG, VIP, LEP, CFTR, MIF, INS
23	methylcellulose32	10.3	KIT, KITLG, CD14, CD59, CDH1, FGF2
24	nifedipine32 9 9	12.3	PIK3CG, GCG, VIP, LEP, CHGA, UGT1A
25	sodium nitroprusside32	10.3	PCNA, VIP, IREB2, IL5, CCK, ALDH2
26	rapamycin32 42	11.3	PIK3CG, SGK1, KIT, KITLG, GCG, BRAF
27	lipid32	10.3	PIK3CG, SGK1, KITLG, PC, GCK, GCG
28	doxycycline32 9 9	12.3	GCK, CD79A, CDKN2A, CD40LG, MMP3, MMP9
29	h2o232	10.2	PIK3CG, SGK1, KITLG, GCK, VIP, LGALS3
30	pioglitazone32 9 9	12.2	GCG, LPL, LEP, MMP7, MMP9, INS
31	fatty acid32	10.1	PC, GCK, GCG, SERPINA6, BRAF, LIPF
32	15-deoxy-delta-12,14-prostaglandin j232	10.1	PIK3CG, FGF2, IL10, IL1B, IL4, IL6
33	ly29400232	10.1	PIK3CG, SGK1, GCK, GCG, LEP, MUC2
34	fenofibrate32 9 9	12.0	LPL, LEP, CETP, CD40LG, MMP9, INS
35	crcs32	9.9	BRAF, MUC1, MUC2, S100A8, MSH2, MSH6
36	pdtc32	9.9	PIK3CG, BCL2, XDH, MMP9, IL1A, IL1B
37	thymidine32 18	10.8	REG3A, KIT, KITLG, PCNA, VIP, VDR
38	estrogen32	9.7	PCNA, GCG, SERPINA6, VIP, LPL, VDR
39	gefitinib32 34 9 9	12.6	PIK3CG, KIT, GCG, CDH1, MMP9, FGF2
40	diclofenac32 34 9 9	12.6	UGT1A, UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT2B15
41	butyrate32	9.4	KITLG, PCNA, GCK, GCG, VDR, BCL2
42	serine32	9.4	PIK3CG, SGK1, KIT, KITLG, GCK, GCG
43	quercetin32 42 9 18 9	13.4	PIK3CG, BCL2, UGT1A, UGT1A1, UGT1A3, XDH
44	progesterone32 42 9 18 9	13.2	KIT, PCNA, GCK, SERPINA6, BRAF, RARB
45	vegf32	9.1	PIK3CG, KIT, KITLG, PCNA, GCG, VIP
46	prednisolone32 9 9	11.1	KITLG, SERPINA6, VIP, MPO, CD79A, CD14
47	vitamin a32 9 18 9	12.0	SERPINA6, LPL, VDR, RARB, LEP, B2M
48	glutamine32	8.9	PIK3CG, KIT, PC, PCNA, GCK, GCG
49	resveratrol32 9 18 9	11.6	PIK3CG, PCNA, VDR, BCL2, UGT1A, XDH
50	imatinib32 34 9 9	10.9	PIK3CG, KIT, KITLG, VIP, BRAF, BCL2

Cellular components related to duodenitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	10.9	CSN1S1, CSF2, SOD1, CXCL17, CXCL1, PRL
2	integral to plasma membrane	GO:005887	10.6	TLR2, HFE, HCRTR2, HCRTR1, ABCC2, ABCC1
3	secretory granule	GO:030141	10.6	GHRL, CTSG, LTF, ELANE, HCRT, TF
4	external side of plasma membrane	GO:009897	10.0	HLA-DRB1, TNF, CTSB, TLR2, TLR4, TGFBR2
5	cell surface	GO:009986	10.0	SHH, ABCB1, ELANE, TLR2, TIMP2, TGFA
6	extracellular space	GO:005615	9.6	LALBA, LEP, LPL, GCG, KITLG, KIT
7	plasma membrane	GO:005886	9.1	PKM, HLA-DQB1, HLA-DQA1, HLA-B, HLA-A, ESR1

Biological processes related to duodenitis according to GeneDecks:

(show all 33)

id	Name	GO ID	Score	Top Affiliating Genes
1	digestion	GO:007586	11.6	PGC, MUC5AC, UGT1A1, SCTR, FABP2, CCKBR
2	immune response	GO:006955	11.5	CTSG, PTGER4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HFE
3	G-protein coupled receptor signaling pathway	GO:007186	11.4	PTGER3, PTGER1, SST, EDN1, DEFB1, DEFB4A
4	endocrine pancreas development	GO:031018	11.3	NEUROG3, SLC2A2, PDX1, PTF1A, GIP, IL6
5	extracellular matrix disassembly	GO:022617	11.2	PRSS1, TIMP2, TIMP1, ELANE, PLG, CTSG
6	inflammatory response	GO:006954	11.2	IL8, CCL5, F2R, CALCA, TNF, PTGS2
7	cellular iron ion homeostasis	GO:006879	11.1	SOD1, SLC11A2, SLC40A1, SLC46A1, CP, HAMP
8	feeding behavior	GO:007631	10.9	NKX2-1, NPY, HCRTR2, HCRTR1, PYY, CALCA
9	aging	GO:007568	10.8	TIMP1, TIMP3, TGFB1, SI, ADA, ADRB3
10	response to lipopolysaccharide	GO:032496	10.8	EPHA3, NKX2-1, CPS1, TLR4, ELANE, EDN1
11	response to heat	GO:009408	10.7	SOD1, NOS3, SST, CALCA, HSPA4, CCKAR
12	positive regulation of cell proliferation	GO:008284	10.6	EDN1, SHH, KRAS, PDX1, NRAS, EGF
13	xenobiotic metabolic process	GO:006805	10.6	PTGS2, PTGS1, CYP3A7, CYP3A4, CYP2C19, CYP27B1
14	response to glucocorticoid stimulus	GO:051384	10.5	TNF, PTGS2, KRAS, SLC9A3, SI, ADIPOQ
15	positive regulation of nitric oxide biosynthetic process	GO:045429	10.5	TLR4, TLR2, EDN1, PTGS2, TNF, ESR1
16	negative regulation of growth of symbiont in host	GO:044130	10.5	TLR2, ELANE, LTA, CTSG, TNF, MBL2
17	response to estradiol stimulus	GO:032355	10.4	NOS3, SHH, TGFB1, TFF1, SLC6A4, CTNNB1
18	positive regulation of apoptotic process	GO:043065	10.4	TNF, PTGS2, CTNNB1, NOS3, TLR4, PRKDC
19	response to organic cyclic compound	GO:014070	10.4	GIP, PTGS2, CTSB, NOS3, COMT, TIMP3
20	positive regulation of cytokine secretion	GO:050715	10.4	TLR2, PTGER4, TNF, IL1A, IL10, INS
21	negative regulation of cell proliferation	GO:008285	10.1	CXCL1, TGIF1, TGFB1, TIMP2, PDX1, NOS3
22	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.1	SHH, PDX1, SMAD4, PPARA, CTNNB1, TNF
23	response to ethanol	GO:045471	10.0	NOS3, SHH, TLR4, SOD1, NKX2-1, ADIPOQ
24	positive regulation of mitosis	GO:045840	9.9	IL1A, IL1B, IGF1, TNF, EDN1, EGF
25	response to hypoxia	GO:001666	9.7	EDN1, MMP9, LEP, BCL2, IL1A, IL1B
26	positive regulation of smooth muscle cell proliferation	GO:048661	9.6	PTGS2, EDN1, ELANE, HIF1A, TNF, HMOX1
27	positive regulation of transcription, DNA-dependent	GO:045893	9.5	SMAD4, NR5A2, PPARA, CTNNB1, TNF, SHH
28	response to drug	GO:042493	9.2	CPS1, SLC6A4, SOD1, SST, PTGS2, TNF
29	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.1	ESR2, TNF, HIPK2, NEUROG3, ESR1, IL6
30	negative regulation of apoptotic process	GO:043066	9.1	APC, FABP1, ALB, CAT, GHRL, TP53
31	small molecule metabolic process	GO:044281	9.1	PKM, DDC, PTGS1, PTGS2, TREH, HMOX1
32	anti-apoptosis	GO:006916	9.1	IGF1, HSPA1B, GHRL, HMOX1, TNF, NOS3
33	response to estrogen stimulus	GO:043627	9.0	TIMP3, CYP27B1, HMOX1, GHRL, ESR1, CA2

Molecular functions related to duodenitis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:005179	10.9	GCG, SST, PPY, COPA, EDN1, PRL
2	retinoic acid binding	GO:001972	10.7	UGT2B7, UGT2B4, UGT2B15, UGT1A6, UGT1A4, UGT1A3
3	glucuronosyltransferase activity	GO:015020	10.5	UGT2B7, UGT2B4, UGT2B15, UGT1A6, UGT1A4, UGT1A3
4	cytokine activity	GO:005125	10.1	IL5, IL6, TNF, LTA, EDN1, CSF2
5	protein homodimerization activity	GO:042803	10.0	SMAD4, NR0B2, PTGS2, HMOX1, CAT, GPD1
6	growth factor activity	GO:008083	9.7	IGF1, EGF, TGFA, TGFB1, TFF1, CXCL1
7	enzyme binding	GO:019899	9.6	HMOX1, TP53, PTGS2, CYP3A4, CYP2C19, CTNNB1
8	protein binding	GO:005515	6.1	SHH, KRAS, KRT7, PKM, NOS3, LTF