MCID: DYS070
MIFTS: 32

Dysalbuminemic Hyperthyroxinemia malady

Genetic diseases (common) category

Summaries for Dysalbuminemic Hyperthyroxinemia

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MalaCards based summary: Dysalbuminemic Hyperthyroxinemia is related to hyperthyroxinemia and hypothyroidism. An important gene associated with Dysalbuminemic Hyperthyroxinemia is ALB (albumin), and among its related pathways is FOXA2 and FOXA3 transcription factor networks. The compounds kebuzone and pirprofen have been mentioned in the context of this disorder. Affiliated tissues include thyroid and testes.

Aliases & Classifications for Dysalbuminemic Hyperthyroxinemia

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Dysalbuminemic Hyperthyroxinemia, Aliases & Descriptions:

Name: Dysalbuminemic Hyperthyroxinemia 22 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Dysalbuminemic Hyperthyroxinemia

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Diseases related to Dysalbuminemic Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1hyperthyroxinemia31.7ALB, OXA1L, SERPINA7, TTR
2hypothyroidism30.7TTR, SERPINA7
3hepatitis30.5SERPINA7, TTR
4thyroiditis10.7
5thyroid hormone resistance10.3
6congenital hypothyroidism10.3
7multinodular goiter10.3
8goiter10.3
9thyrotoxicosis10.3
10protein-losing enteropathy10.0ALB
11acquired immunodeficiency syndrome10.0ALB
12euthyroid sick syndrome10.0SERPINA7
13nutritional deficiency disease10.0ALB, TTR
14protein-energy malnutrition10.0ALB, TTR
15autonomic neuropathy10.0ALB, TTR
16galactosemia10.0ALB, TTR
17hyperhomocysteinemia10.0ALB, TTR
18amyloidosis10.0ALB, TTR
19diarrhea10.0ALB, TTR
20primary hyperoxaluria10.0TTR, ALB
21liver disease10.0ALB, TTR
22neuropathy10.0ALB, TTR
23polyneuropathy10.0TTR, SERPINA7
24proteinuria10.0ALB, TTR
25diabetes mellitus, insulin-dependent10.0SERPINA7, ALB
26brain edema10.0OXA1L, ALB
27liver cirrhosis10.0SERPINA7, ALB
28uremia10.0ALB, OXA1L
29tetanus10.0ALB, OXA1L
30glomerulonephritis10.0OXA1L, ALB
31microvascular complications of diabetes 310.0ALB, OXA1L
32deficiency anemia10.0ALB, SERPINA7, TTR
33hyperglycemia10.0ALB, OXA1L
34congenital human immunodeficiency virus10.0OXA1L, SERPINA7
35hepatitis b10.0ALB, OXA1L
36myeloma10.0ALB, OXA1L
37hiv-110.0SERPINA7, OXA1L
38hepatocellular carcinoma10.0ALB, OXA1L, SERPINA7
39diabetes mellitus, noninsulin-dependent10.0ALB, OXA1L
40chronic kidney failure9.9TTR, SERPINA7, OXA1L, ALB

Graphical network of the top 20 diseases related to Dysalbuminemic Hyperthyroxinemia:



Diseases related to dysalbuminemic hyperthyroxinemia

Symptoms for Dysalbuminemic Hyperthyroxinemia

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Drugs & Therapeutics for Dysalbuminemic Hyperthyroxinemia

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Drug clinical trials:

Search ClinicalTrials for Dysalbuminemic Hyperthyroxinemia

Search NIH Clinical Center for Dysalbuminemic Hyperthyroxinemia

Genetic Tests for Dysalbuminemic Hyperthyroxinemia

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Genetic tests related to Dysalbuminemic Hyperthyroxinemia:

id Genetic test Affiliating Genes
1 Dysalbuminemic Hyperthyroxinemia22 ALB

Anatomical Context for Dysalbuminemic Hyperthyroxinemia

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MalaCards organs/tissues related to Dysalbuminemic Hyperthyroxinemia:

33
Thyroid, Testes

Animal Models for Dysalbuminemic Hyperthyroxinemia or affiliated genes

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Publications for Dysalbuminemic Hyperthyroxinemia

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Articles related to Dysalbuminemic Hyperthyroxinemia:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction. (24494774)
2014
2
A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia. (24646103)
2014
3
Familial dysalbuminemic hyperthyroxinemia in a 4-year-old girl with hyperactivity, palpitations and advanced dental age: how gold standard assays may be misleading. (25153218)
2014
4
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
5
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. (19282355)
2009
6
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. (15068631)
2004
7
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. (12743361)
2003
8
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. (12099390)
2002
9
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
10
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. (10946882)
2000
11
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
12
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. (10526251)
1999
13
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
14
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. (8929830)
1996
15
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. (8964572)
1996
16
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
17
Familial dysalbuminemic hyperthyroxinemia in pregnancy. (8548059)
1995
18
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. (7829599)
1995
19
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (7852505)
1995
20
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
21
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. (8288714)
1994
22
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
23
Free thyroxine measured by the Ciba Corning ACS-180 on samples from patients with familial dysalbuminemic hyperthyroxinemia. (8353971)
1993
24
Fluorescence investigations of albumin from patients with familial dysalbuminemic hyperthyroxinemia. (8475173)
1993
25
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
26
Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report. (1769174)
1991
27
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
28
Can the type of variant albumin in familial dysalbuminemic hyperthyroxinemia be determined by measuring iodothyronines in serum? (2253589)
1990
29
Studies on the nature of iodothyronine binding in familial dysalbuminemic hyperthyroxinemia. (2370303)
1990
30
Diagnosis of familial dysalbuminemic hyperthyroxinemia and investigation of the nature of the variant albumin. (2135643)
1990
31
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
32
Coexistence of familial dysalbuminemic hyperthyroxinemia with familial hypercholesterolemia and multiple lipoprotein type hyperlipidemia. (3407659)
1988
33
Free thyroxin in familial dysalbuminemic hyperthyroxinemia, as measured by five assays. (3349617)
1988
34
Normal cellular uptake of thyroxine from serum of patients with familial dysalbuminemic hyperthyroxinemia or elevated thyroxine-binding globulin. (3142912)
1988
35
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
36
A four generation study of familial dysalbuminemic hyperthyroxinemia: diagnosis in the presence of an acquired excess of thyroxine-binding globulin. (3110251)
1987
37
Familial dysalbuminemic hyperthyroxinemia associated with primary thyroid disease. (3812513)
1987
38
Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. (3112186)
1987
39
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
40
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
41
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
42
Hepatic bioavailability of thyroxine and testosterone in familial dysalbuminemic hyperthyroxinemia. (4031018)
1985
43
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
44
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
45
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
46
Case report: familial dysalbuminemic hyperthyroxinemia--a variant. (6590861)
1984
47
Measurement of free thyroxin in patients with familial dysalbuminemic hyperthyroxinemia. (6705204)
1984
48
Thyroxine distribution and metabolism in familial dysalbuminemic hyperthyroxinemia. (6746864)
1984
49
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
50
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982

Variations for Dysalbuminemic Hyperthyroxinemia

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Expression for genes affiliated with Dysalbuminemic Hyperthyroxinemia

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Search GEO for disease gene expression data for Dysalbuminemic Hyperthyroxinemia.

Pathways for genes affiliated with Dysalbuminemic Hyperthyroxinemia

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Pathways related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ALB, TTR

Compounds for genes affiliated with Dysalbuminemic Hyperthyroxinemia

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Compounds related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1kebuzone459.9OXA1L, ALB
2pirprofen459.9OXA1L, ALB
3sodium octanoate459.9OXA1L, ALB
4azapropazone45 1310.9OXA1L, ALB
5rhsa459.8ALB, OXA1L
6dansylsarcosine459.8ALB, OXA1L
7tolmetin glucuronide459.8ALB, OXA1L
8acetyldigitoxin45 1310.8OXA1L, ALB
9hhpa459.8OXA1L, ALB
10dansylamide45 1310.8ALB, OXA1L
11eprex459.8ALB, OXA1L
12(s)-ketoprofen459.8OXA1L, ALB
13sulfisoxazole45 51 61 1312.8ALB, OXA1L
14oxyphenbutazone45 1310.8ALB, OXA1L
15polyvinylpyrrolidone459.8OXA1L, ALB
16cyclosarin459.8OXA1L, ALB
17fenoprofen30 45 1311.8OXA1L, ALB
18n(epsilon)-(carboxymethyl)lysine459.8ALB, OXA1L
19indoxyl sulfate459.8ALB, OXA1L
20polyvinyl alcohol459.8ALB, OXA1L
21tolmetin45 1310.8OXA1L, ALB
22cefoperazone45 1310.7OXA1L, ALB
23tween 80459.7OXA1L, ALB
24aopp459.7OXA1L, ALB
25decanoic acid45 30 1311.7ALB, OXA1L
26suprofen45 1310.7OXA1L, ALB
27octanoate459.7OXA1L, ALB
28phenylbutazone45 1310.6OXA1L, ALB
29idpn459.5TTR, ALB
30hydroxyethyl starch459.5OXA1L, ALB
31enflurane51 45 1311.5ALB, OXA1L
328-anilino-1-naphthalenesulfonic acid459.4TTR, OXA1L
33deae459.4TTR, OXA1L
34furosemide45 61 30 51 26 1314.2SERPINA7, OXA1L, ALB
35phenytoin45 51 30 1312.2ALB, OXA1L, SERPINA7
36chloroform459.1TTR, OXA1L
37ethacrynic acid45 1310.1ALB, OXA1L
38flurbiprofen45 30 51 1312.1ALB, OXA1L, TTR
39glutaraldehyde459.0ALB, OXA1L, TTR
40liothyronine51 26 1311.0TTR, SERPINA7, ALB
41diclofenac45 30 51 1311.9TTR, SERPINA7, ALB
42pcbs458.9TTR, SERPINA7
43urea45 26 1310.9TTR, SERPINA7, ALB
44vitamin a45 26 1310.7TTR, SERPINA7, ALB
45aspirin45 51 30 2611.7OXA1L, SERPINA7, TTR
46fibrinogen458.6ALB, OXA1L, TTR
47diflunisal45 139.4ALB, OXA1L, SERPINA7, TTR
48salicylic acid45 309.4TTR, SERPINA7, OXA1L, ALB
49sodium dodecylsulfate458.4TTR, SERPINA7, OXA1L, ALB
50thyroxine45 269.4ALB, OXA1L, SERPINA7, TTR

GO Terms for genes affiliated with Dysalbuminemic Hyperthyroxinemia

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Cellular components related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432348.5ALB, OXA1L, TTR
2extracellular regionGO:00055768.5ALB, SERPINA7, TTR
3extracellular spaceGO:00056158.2ALB, SERPINA7, TTR

Molecular functions related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:00425629.0SERPINA7, TTR

Products for genes affiliated with Dysalbuminemic Hyperthyroxinemia

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Sources for Dysalbuminemic Hyperthyroxinemia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet