Dysalbuminemic Hyperthyroxinemia malady

MalaCards: Dysalbuminemic Hyperthyroxinemia is related to hyperthyroxinemia and hypothyroidism. An important gene associated with Dysalbuminemic Hyperthyroxinemia is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7). The compounds glutaraldehyde and 8-anilino-1-naphthalenesulfonic acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

dysalbuminemic hyperthyroxinemia 16 33 43

Diseases related to dysalbuminemic hyperthyroxinemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 76)

id	Related Disease	Score	Top Affiliating Genes
1	hyperthyroxinemia	33.9	SERPINA7, ALB, TTR, OXA1L
2	hypothyroidism	30.4	TTR, ALB, SERPINA7
3	thyrotoxicosis	29.8	TTR, ALB
4	congenital hypothyroidism	29.8	SERPINA7, ALB
5	thyroiditis	28.0	OXA1L, TTR, SERPINA7, ALB
6	endemic goiter	12.9	TTR, SERPINA7
7	nutritional deficiency disease	12.6	TTR, ALB
8	decubitus ulcer	12.6	TTR, ALB
9	euthyroid sick syndrome	12.6	SERPINA7, ALB
10	chronic kidney failure	12.6	TTR, ALB
11	protein-energy malnutrition	12.6	ALB, TTR
12	hepatic encephalopathy	12.6	ALB, TTR
13	autonomic neuropathy	12.6	ALB, TTR
14	keratomalacia	12.6	TTR, ALB
15	autonomic dysfunction	12.6	ALB, TTR
16	galactosemia	12.5	TTR, ALB
17	alcoholic liver cirrhosis	12.5	ALB, TTR
18	phenylketonuria	12.5	ALB, TTR
19	obstructive jaundice	12.5	TTR, ALB
20	protein-losing enteropathy	12.5	ALB, OXA1L
21	thrombocytosis	12.5	ALB, SERPINA7
22	immune-complex glomerulonephritis	12.5	OXA1L, ALB
23	hyperuricemia	12.5	ALB, TTR
24	proliferative glomerulonephritis	12.5	ALB, OXA1L
25	rickets	12.5	ALB, TTR
26	focal segmental glomerulosclerosis	12.5	TTR, ALB
27	pure red-cell aplasia	12.5	OXA1L, ALB
28	nonalcoholic steatohepatitis	12.5	ALB, TTR
29	juvenile rheumatoid arthritis	12.5	ALB, TTR
30	brain edema	12.4	ALB, OXA1L
31	cork-handlers' disease	12.4	ALB, TTR
32	dental caries	12.4	ALB, OXA1L
33	glycogen storage disease	12.4	ALB, TTR
34	primary hyperoxaluria	12.4	TTR, ALB
35	iron overload	12.4	SERPINA7, ALB
36	headache	12.4	ALB, TTR
37	growth hormone deficiency	12.4	SERPINA7, ALB
38	hepatic fibrosis renal cysts mental retardation	12.4	ALB, OXA1L
39	retinol binding protein	12.4	TTR, ALB
40	diphtheria	12.3	ALB, OXA1L
41	primary open angle glaucoma	12.2	TTR, ALB
42	hypercalcemia	12.2	ALB, OXA1L
43	hyperhomocysteinemia	12.2	ALB, TTR
44	jaundice	12.1	TTR, ALB
45	respiratory failure	12.1	ALB, TTR, SERPINA7
46	goiter	12.1	SERPINA7, ALB, TTR
47	polyneuropathy	12.1	ALB, SERPINA7, TTR
48	photosensitive trichothiodystrophy	12.1	TTR, ALB, SERPINA7
49	spinal cord injury	12.1	SERPINA7, ALB, TTR
50	hyperthyroidism	12.1	ALB, SERPINA7, TTR

Approved drugs:

Drug clinical trials:

Genetic tests related to dysalbuminemic hyperthyroxinemia:

id	Genetic test	Affiliating Genes
1	Dysalbuminemic Hyperthyroxinemia clinical/research	ALB

MalaCards organs/tissues related to dysalbuminemic hyperthyroxinemia:

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Articles related to dysalbuminemic hyperthyroxinemia:

(show all 19)

id	Title	Authors	Year	Affiliating Genes
1	Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. (15068631)	Hoshikawa S.... Yoshida K.	2004	ALB, SERPINA7
2	Structural basis of albumin-thyroxine interactions an d familial dysalbuminemic hyperthyroxinemia. (12743361)	Petitpas I.... Curry S.	2003	ALB, OXA1L
3	Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)	Pohlenz J.... Refetoff S.	2001	ALB
4	Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. (10946882)	Pannain S.... Refetoff S.	2000	ALB
5	A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)	Wada N.... Koike T.	1997	ALB
6	Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. (8929830)	Premachandra B.N.... Williams I.K.	1996	TTR, SERPINA7
7	Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. (8702585)	Petersen C.E.... Bhagavan N.V.	1996	OXA1L
8	Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)	Heufelder A.E.... Gharib H.	1995	ALB
9	Familial dysalbuminemic hyperthyroxinemia in pregnancy. (8548059)	Sachmechi I.... Schussler G.C.	1995	ALB
10	Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (7852505)	Rushbrook J.I.... Divino C.M.	1995	ALB
11	Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. (8288714)	Langsteger W.... Eber O.	1994	ALB
12	An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)	Sunthornthepvarakul T.... Retetoff S.	1994	ALB
13	Fluorescence investigations of albumin from patients with familial dysalbuminemic hyperthyroxinemia. (8475173)	Dughi C.... Jameson D.M.	1993	ALB, OXA1L
14	The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)	Katz N.... Heironimus J.D.	1993	ALB
15	Elevated thyroxine and free thyroxine in euthyroid pa tients: familial dysalbuminemic hyperthyroxinemia. (2109350)	Haas S.	1990	ALB
16	Can the type of variant albumin in familial dysalbuminemic hyperthyroxinemia be determined by measuring iodothyronines in serum? (2253589)	Takamatsu J.... Ohsawa N.	1990	ALB
17	Studies on the nature of iodothyronine binding in familial dysalbuminemic hyperthyroxinemia. (2370303)	Divino C.M.... Schussler G.C.	1990	ALB
18	Diagnosis of familial dysalbuminemic hyperthyroxinemia and investigation of the nature of the variant albumin. (2135643)	Takamatsu J.... Ohsawa N.	1990	ALB
19	Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)	Ruiz M.... Ingbar S.H.	1982	ALB

Genes related to dysalbuminemic hyperthyroxinemia according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
2	OXA1L	oxidase (cytochrome c) assembly 1-like	11.0	Publications
3	ALB	albumin	11.0	Publications
4	TTR	transthyretin	11.0	Publications

Compounds related to dysalbuminemic hyperthyroxinemia according to GeneDecks:

(show top 50)    (show all 90)

id	Compound	Score	Top Affiliating Genes
1	glutaraldehyde32	10.4	TTR
2	8-anilino-1-naphthalenesulfonic acid32	9.6	TTR, OXA1L
3	idpn32	9.5	TTR, ALB
4	deae32	9.5	OXA1L, TTR
5	azapropazone32 9 9	11.5	OXA1L, ALB
6	pirprofen32	9.5	OXA1L, ALB
7	rhsa32	9.5	ALB, OXA1L
8	dansylsarcosine32	9.4	ALB, OXA1L
9	kebuzone32	9.4	OXA1L, ALB
10	sodium octanoate32	9.4	ALB, OXA1L
11	tolmetin glucuronide32	9.4	OXA1L, ALB
12	pcbs32	9.4	TTR, SERPINA7
13	hhpa32	9.4	OXA1L, ALB
14	acetyldigitoxin32 9 9	11.4	OXA1L, ALB
15	fenoprofen32 9 9	11.4	OXA1L, ALB
16	eprex32	9.4	OXA1L, ALB
17	dansylamide32 9 9	11.4	ALB, OXA1L
18	sulfisoxazole32 42 9 9	12.4	OXA1L, ALB
19	oxyphenbutazone32 9 9	11.4	OXA1L, ALB
20	(s)-ketoprofen32	9.4	ALB, OXA1L
21	tolmetin32 9 9	11.4	OXA1L, ALB
22	cyclosarin32	9.4	ALB, OXA1L
23	polyvinylpyrrolidone32	9.4	OXA1L, ALB
24	polyvinyl alcohol32	9.4	OXA1L, ALB
25	n(epsilon)-(carboxymethyl)lysine32	9.4	OXA1L, ALB
26	indoxyl sulfate32	9.3	OXA1L, ALB
27	tween 8032	9.3	ALB, OXA1L
28	cefoperazone32 9 9	11.3	OXA1L, ALB
29	aopp32	9.3	ALB, OXA1L
30	decanoic acid32 9 9	11.3	ALB, OXA1L
31	octanoate32	9.3	ALB, OXA1L
32	suprofen32 9 9	11.2	OXA1L, ALB
33	phenylbutazone32 9 9	11.2	OXA1L, ALB
34	hydroxyethyl starch32	9.1	OXA1L, ALB
35	Levothyroxine9 9	10.1	TTR, ALB, SERPINA7
36	Liotrix9 9	10.1	ALB, TTR, SERPINA7
37	liothyronine34 9 18 9	12.0	ALB, SERPINA7, TTR
38	diclofenac32 34 9 9	12.0	ALB, TTR, SERPINA7
39	flurbiprofen32 34 9 9	11.9	OXA1L, TTR, ALB
40	furosemide32 42 34 9 18 9	13.9	ALB, OXA1L, SERPINA7
41	enflurane32 9 9	10.9	OXA1L, ALB
42	phenytoin32 34 9 9	11.9	OXA1L, SERPINA7, ALB
43	urea32 9 18 9	11.9	TTR, ALB, SERPINA7
44	aspirin32 34 18	10.9	SERPINA7, OXA1L, TTR
45	chlorpheniramine32 9 18 9	11.7	OXA1L, ALB
46	vitamin a32 9 18 9	11.6	TTR, SERPINA7, ALB
47	diflunisal32 9 9	10.4	SERPINA7, ALB, TTR, OXA1L
48	salicylic acid32	8.4	TTR, OXA1L, ALB, SERPINA7
49	sodium dodecylsulfate32	8.4	TTR, SERPINA7, ALB, OXA1L
50	thyroxine32 18	9.4	OXA1L, ALB, TTR, SERPINA7

Cellular components related to dysalbuminemic hyperthyroxinemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.6	SERPINA7, ALB, TTR

Molecular functions related to dysalbuminemic hyperthyroxinemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone binding	GO:042562	9.4	SERPINA7, TTR