MCID: DYS070
MIFTS: 29

Dysalbuminemic Hyperthyroxinemia malady

Summaries for Dysalbuminemic Hyperthyroxinemia

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47OMIM, 33MalaCards
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MalaCards: Dysalbuminemic Hyperthyroxinemia is related to hyperthyroxinemia and thyrotoxicosis. An important gene associated with Dysalbuminemic Hyperthyroxinemia is ALB (albumin), and among its related pathways is FOXA2 and FOXA3 transcription factor networks. The compounds kebuzone and tolmetin glucuronide have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

Description from OMIM:47 103600

Aliases & Classifications for Dysalbuminemic Hyperthyroxinemia

Sources:
20GeneTests, 47OMIM, 61UMLS
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Aliases & Descriptions:

dysalbuminemic hyperthyroxinemia 20 47 61


Related Diseases for Dysalbuminemic Hyperthyroxinemia

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17GeneCards, 18GeneDecks
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Diseases related to Dysalbuminemic Hyperthyroxinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1hyperthyroxinemia31.6ALB, SERPINA7, TTR, OXA1L
2thyrotoxicosis30.4SERPINA7
3congenital hypothyroidism30.4SERPINA7
4thyroiditis30.4SERPINA7
5multinodular goiter10.3
6familial hypercholesterolemia10.3
7familial hypothyroidism10.3
8hypercholesterolemia10.3
9acquired immunodeficiency syndrome10.0ALB
10protein-losing enteropathy10.0ALB
11nephrotic syndrome10.0ALB
12arthritis10.0ALB
13hepatic encephalopathy10.0ALB
14goiter10.0SERPINA7
15malaria10.0ALB
16hyperthyroidism10.0SERPINA7
17euthyroid sick syndrome10.0SERPINA7
18graves' disease10.0SERPINA7
19pituitary adenoma10.0SERPINA7
20peritonitis10.0ALB
21metabolic acidosis10.0ALB
22hypercalcemia10.0ALB
23rheumatoid arthritis10.0OXA1L
24dental caries10.0OXA1L
25nutritional deficiency disease10.0TTR, ALB
26myocardial infarction10.0OXA1L
27protein-energy malnutrition10.0ALB, TTR
28autonomic neuropathy10.0ALB, TTR
29polyneuropathy10.0TTR, SERPINA7
30galactosemia10.0ALB, TTR
31hypothyroidism10.0TTR, SERPINA7
32primary hyperoxaluria10.0ALB, TTR
33asthma10.0OXA1L
34uremia10.0OXA1L, ALB
35hyperhomocysteinemia10.0ALB, TTR
36diabetes mellitus10.0OXA1L, ALB
37hepatitis b10.0ALB, OXA1L
38brain edema10.0ALB, OXA1L
39hepatitis10.0TTR, SERPINA7
40deficiency anemia10.0ALB, SERPINA7, TTR
41diabetic nephropathy10.0ALB, OXA1L
42tetanus10.0ALB, OXA1L
43type 1 diabetes10.0ALB, SERPINA7
44hepatocellular carcinoma10.0OXA1L, SERPINA7, ALB
45chronic kidney failure10.0ALB, SERPINA7, TTR, OXA1L
46sepsis10.0OXA1L, TTR, SERPINA7, ALB
47liver cirrhosis10.0OXA1L, TTR, SERPINA7, ALB

Graphical network of the top 20 diseases related to Dysalbuminemic Hyperthyroxinemia:



Diseases related to dysalbuminemic hyperthyroxinemia

Clinical Features for Dysalbuminemic Hyperthyroxinemia

Sources:
47OMIM
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Clinical features from OMIM:

103600

Drugs & Therapeutics for Dysalbuminemic Hyperthyroxinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dysalbuminemic Hyperthyroxinemia

Drug clinical trials:

Search ClinicalTrials for Dysalbuminemic Hyperthyroxinemia

Search NIH Clinical Center for Dysalbuminemic Hyperthyroxinemia

Search CenterWatch for Dysalbuminemic Hyperthyroxinemia

Genetic Tests for Dysalbuminemic Hyperthyroxinemia

Sources:
20GeneTests
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Genetic tests related to Dysalbuminemic Hyperthyroxinemia:

id Genetic test Affiliating Genes
1 Dysalbuminemic Hyperthyroxinemia20 ALB

Anatomical Context for Dysalbuminemic Hyperthyroxinemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Dysalbuminemic Hyperthyroxinemia:

33
Thyroid

Animal Models for Dysalbuminemic Hyperthyroxinemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Dysalbuminemic Hyperthyroxinemia

Sources:
51PubMed
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Articles related to Dysalbuminemic Hyperthyroxinemia:

(show all 50)
idTitleAuthorsYear
1
Spuriously high free thyroxine values in familial dysalbuminemic hyperthyroxinemia. (21149501)
2011
2
Familial dysalbuminemic hyperthyroxinemia: a persistent diagnostic challenge. (19282355)
2009
3
Artifactually elevated serum-free thyroxine levels measured by equilibrium dialysis in a pregnant woman with familial dysalbuminemic hyperthyroxinemia. (15068631)
2004
4
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. (12743361)
2003
5
Familial dysalbuminemic hyperthyroxinemia: a rare example of albumin polymorphism and its rapid molecular diagnosis. (12099390)
2002
6
Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene. (11743520)
2001
7
Familial dysalbuminemic hyperthyroxinemia in a Swiss family caused by a mutant albumin (R218P) shows an apparent discrepancy between serum concentration and affinity for thyroxine. (10946882)
2000
8
Structural investigations of a new familial dysalbuminemic hyperthyroxinemia genotype. (10430791)
1999
9
A point mutation in the albumin gene in a Chinese patient with familial dysalbuminemic hyperthyroxinemia. (10526251)
1999
10
A novel missense mutation in codon 218 of the albumin gene in a distinct phenotype of familial dysalbuminemic hyperthyroxinemia in a Japanese kindred. (9329347)
1997
11
Inhibition of serum protein binding of thyroxine in a hypothyroid patient with familial dysalbuminemic hyperthyroxinemia. (8929830)
1996
12
Familial dysalbuminemic hyperthyroxinemia and thyroid hormone autoantibodies: interference in current free thyroid hormone assays. (8964572)
1996
13
Mutations in a specific human serum albumin thyroxine binding site define the structural basis of familial dysalbuminemic hyperthyroxinemia. (8702585)
1996
14
Familial dysalbuminemic hyperthyroxinemia: cumulative experience in 29 consecutive patients. (15251607)
1995
15
Familial dysalbuminemic hyperthyroxinemia in pregnancy. (8548059)
1995
16
Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. (7829599)
1995
17
Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (7852505)
1995
18
An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families. (8048949)
1994
19
Postpartum thyroiditis and familial dysalbuminemic hyperthyroxinemia. (8288714)
1994
20
The effects of danazol on a patient with familial dysalbuminemic hyperthyroxinemia. (8422721)
1993
21
Free thyroxine measured by the Ciba Corning ACS-180 on samples from patients with familial dysalbuminemic hyperthyroxinemia. (8353971)
1993
22
Fluorescence investigations of albumin from patients with familial dysalbuminemic hyperthyroxinemia. (8475173)
1993
23
Prevalence of familial dysalbuminemic hyperthyroxinemia in serum samples received for thyroid testing. (1868606)
1991
24
Familial dysalbuminemic hyperthyroxinemia associated with multinodular goiter and elevated radioiodine uptake. A case report. (1769174)
1991
25
Elevated thyroxine and free thyroxine in euthyroid patients: familial dysalbuminemic hyperthyroxinemia. (2109350)
1990
26
Can the type of variant albumin in familial dysalbuminemic hyperthyroxinemia be determined by measuring iodothyronines in serum? (2253589)
1990
27
Studies on the nature of iodothyronine binding in familial dysalbuminemic hyperthyroxinemia. (2370303)
1990
28
Diagnosis of familial dysalbuminemic hyperthyroxinemia and investigation of the nature of the variant albumin. (2135643)
1990
29
Familial dysalbuminemic hyperthyroxinemia in a Hispanic family. (3341680)
1988
30
Coexistence of familial dysalbuminemic hyperthyroxinemia with familial hypercholesterolemia and multiple lipoprotein type hyperlipidemia. (3407659)
1988
31
Free thyroxin in familial dysalbuminemic hyperthyroxinemia, as measured by five assays. (3349617)
1988
32
Normal cellular uptake of thyroxine from serum of patients with familial dysalbuminemic hyperthyroxinemia or elevated thyroxine-binding globulin. (3142912)
1988
33
Thyroxin binding by human serum albumin after denaturation of the thyroxin-binding globulin in familial dysalbuminemic hyperthyroxinemia. (3129213)
1988
34
Prevalence of familial dysalbuminemic hyperthyroxinemia in Hispanics. (3662294)
1987
35
A four generation study of familial dysalbuminemic hyperthyroxinemia: diagnosis in the presence of an acquired excess of thyroxine-binding globulin. (3110251)
1987
36
Familial dysalbuminemic hyperthyroxinemia associated with primary thyroid disease. (3812513)
1987
37
Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. (3112186)
1987
38
Familial dysalbuminemic hyperthyroxinemia. (3111180)
1987
39
Sex hormone-binding protein in hyperthyroxinemic patients: a discriminator for thyroid status in thyroid hormone resistance and familial dysalbuminemic hyperthyroxinemia. (3084540)
1986
40
Modulation of thyroid parameters by exogenous thyroxine in familial dysalbuminemic hyperthyroxinemia. (3081779)
1986
41
Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with familial dysalbuminemic hyperthyroxinemia. (3919043)
1985
42
Hepatic bioavailability of thyroxine and testosterone in familial dysalbuminemic hyperthyroxinemia. (4031018)
1985
43
Familial dysalbuminemic hyperthyroxinemia (FDH): inadequacy of the "analog" methods for assaying free-T4 levels. (6745298)
1984
44
Effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia. (6693542)
1984
45
Familial dysalbuminemic hyperthyroxinemia: a study of four probands and the kindred of three. (6428777)
1984
46
Case report: familial dysalbuminemic hyperthyroxinemia--a variant. (6590861)
1984
47
Measurement of free thyroxin in patients with familial dysalbuminemic hyperthyroxinemia. (6705204)
1984
48
Thyroxine distribution and metabolism in familial dysalbuminemic hyperthyroxinemia. (6746864)
1984
49
Familial dysalbuminemic hyperthyroxinemia: a syndrome that can be confused with thyrotoxicosis. (6173750)
1982
50
Elevated serum free thyroxine by thyroxine analog radioimmunoassays in euthyroid patients with familial dysalbuminemic hyperthyroxinemia. (7149495)
1982

Genetic Variations for Dysalbuminemic Hyperthyroxinemia

Expression for genes affiliated with Dysalbuminemic Hyperthyroxinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysalbuminemic Hyperthyroxinemia

Search GEO for disease gene expression data for Dysalbuminemic Hyperthyroxinemia.

Pathways for genes affiliated with Dysalbuminemic Hyperthyroxinemia

Sources:
38NCBI BioSystems Database
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Pathways related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ALB, TTR

Compounds for genes affiliated with Dysalbuminemic Hyperthyroxinemia

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1kebuzone459.9ALB, OXA1L
2tolmetin glucuronide459.9OXA1L, ALB
3azapropazone45 1110.8ALB, OXA1L
4sodium octanoate459.8ALB, OXA1L
5pirprofen459.8ALB, OXA1L
6dansylsarcosine459.8OXA1L, ALB
7rhsa459.8ALB, OXA1L
8acetyldigitoxin45 1110.8ALB, OXA1L
9hhpa459.8OXA1L, ALB
10dansylamide45 1110.8ALB, OXA1L
11eprex459.8OXA1L, ALB
12(s)-ketoprofen459.8OXA1L, ALB
13polyvinylpyrrolidone459.8ALB, OXA1L
14sulfisoxazole45 60 50 1112.8ALB, OXA1L
15fenoprofen29 45 1111.8ALB, OXA1L
16oxyphenbutazone45 1110.8OXA1L, ALB
17cyclosarin459.8OXA1L, ALB
18polyvinyl alcohol459.8OXA1L, ALB
19indoxyl sulfate459.8OXA1L, ALB
20n(epsilon)-(carboxymethyl)lysine459.8ALB, OXA1L
21tolmetin45 1110.7OXA1L, ALB
22cefoperazone45 1110.7ALB, OXA1L
23tween 80459.7OXA1L, ALB
24aopp459.7ALB, OXA1L
25decanoic acid45 29 1111.7OXA1L, ALB
26octanoate459.7ALB, OXA1L
27suprofen45 1110.6ALB, OXA1L
28hydroxyethyl starch459.6OXA1L, ALB
29idpn459.6ALB, TTR
30phenylbutazone45 1110.5ALB, OXA1L
318-anilino-1-naphthalenesulfonic acid459.4TTR, OXA1L
32enflurane45 1110.3OXA1L, ALB
33deae459.3OXA1L, TTR
34furosemide45 50 60 29 11 2414.2ALB, SERPINA7, OXA1L
35phenytoin45 50 29 1112.2OXA1L, SERPINA7, ALB
36chloroform459.1OXA1L, TTR
37flurbiprofen45 29 50 1112.0ALB, TTR, OXA1L
38glutaraldehyde459.0ALB, TTR, OXA1L
39Levothyroxine119.0TTR, ALB, SERPINA7
40Liotrix119.0ALB, TTR, SERPINA7
41Liothyronine11 249.9TTR, SERPINA7, ALB
42diclofenac45 29 50 1111.9TTR, SERPINA7, ALB
43urea45 11 2410.8ALB, TTR, SERPINA7
44pcbs458.7TTR, SERPINA7
45vitamin a45 11 2410.6TTR, SERPINA7, ALB
46aspirin45 50 29 2411.5TTR, SERPINA7, OXA1L
47diflunisal45 119.4TTR, OXA1L, SERPINA7, ALB
48salicylic acid45 299.4SERPINA7, OXA1L, TTR, ALB
49sodium dodecylsulfate458.4SERPINA7, OXA1L, TTR, ALB
50thyroxine45 249.4TTR, SERPINA7, ALB, OXA1L

GO Terms for genes affiliated with Dysalbuminemic Hyperthyroxinemia

Sources:
16Gene Ontology
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Cellular components related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5ALB, SERPINA7, TTR
2protein complexGO:0432348.3ALB, TTR, OXA1L

Molecular functions related to Dysalbuminemic Hyperthyroxinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone bindingGO:0425629.0SERPINA7, TTR

Products for genes affiliated with Dysalbuminemic Hyperthyroxinemia

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Sources for Dysalbuminemic Hyperthyroxinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet