MCID: DYS021
MIFTS: 36

Dysautonomia malady

Neuronal diseases category

Summaries for Dysautonomia

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Dysautonomia refers to a disorder of autonomic nervous system (ANS) function. Most physicians view dysautonomia in terms of failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive ANS activities also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.

MalaCards: Dysautonomia, also known as autonomic nervous system disorders, is related to riley-day syndrome and parkinson's disease. An important gene associated with Dysautonomia is IKBKAP (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein), and among its related pathways are NGF-independant TRKA activation and Development MAG-dependent inhibition of neurite outgrowth. The compounds forskolin and lestaurtinib have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are integument and vision/eye.

Wikipedia:63 Dysautonomia (or autonomic dysfunction) is any disease or malfunction of the autonomic nervous system... more...

Aliases & Classifications for Dysautonomia

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43NINDS, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

dysautonomia 43 44
autonomic nervous system disorders 60


Related Diseases for Dysautonomia

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17GeneCards, 18GeneDecks
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Diseases in the Dysautonomia family:

Dysautonomia Like Disorder

Diseases related to Dysautonomia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1riley-day syndrome31.2BDNF, IKBKAP, DBH, NTRK2, NTRK1
2parkinson's disease30.6BDNF, SNCA, DBH
3neuropathy30.5IKBKAP
4autonomic neuropathy30.3IKBKAP, DBH, NTRK1
5fatal familial insomnia30.3PRNP
6polyneuropathy30.2HSPG2
7multiple system atrophy30.2DBH, FMR1, PRNP, SNCA
8hypertension30.1DBH
9hereditary sensory neuropathy30.1NTRK2, NTRK1, IKBKAP
10pure autonomic failure30.1DBH, SNCA
11peripheral neuropathy29.9NTRK1
12dementia29.9FMR1, NTRK2, BDNF, PRNP, SYP, SNCA
13hepatitis29.7HSPG2, DBH
14spinocerebellar ataxia29.7FMR1, SNCA, PRNP
15asthma29.7IKBKAP, S100A12
16pheochromocytoma29.7NTRK2, NTRK1, SYP, SNCA, DBH
17neuroblastoma29.7BDNF, PRNP, DBH, NTRK1, SYP
18epilepsy syndrome29.7DBH, NTRK2, BDNF, FMR1, PRNP
19multiple sclerosis29.7HSPG2, BDNF, NTRK2
20alzheimer's disease29.7NTRK2, SYP, DBH, SNCA, S100A12, BDNF
21autonomic dysfunction10.4
22neuronitis10.3
23motor neuropathy peripheral with dysautonomia10.3
24acute cholinergic dysautonomia10.2
25burns10.1
26burning mouth syndrome10.1
27horner's syndrome10.1
28mouth disease10.1
29nervous system disease10.1
30diabetes mellitus10.1
31leprosy10.1
32chagas disease10.1
33chronic fatigue syndrome10.1
34esophagitis10.1
35myopathy10.1
36anhidrosis10.0NTRK1
37cocaine abuse10.0DBH
38paraganglioma10.0SYP
39down syndrome10.0FMR1, SNCA
40motor neuron disease10.0SNCA, BDNF
41breast cancer10.0SNCA, NTRK1
42nicotine dependence10.0NTRK2
43pick's disease10.0SNCA
44frontotemporal dementia10.0SNCA
45amyloidosis10.0DBH, PRNP, SNCA
46creutzfeldt-jakob syndrome10.0SNCA, PRNP, NTRK1
47neuroaxonal dystrophy10.0NTRK1, SNCA
48oligodendroglioma10.0SYP, HSPG2
49anorexia nervosa10.0BDNF
50olfactory neuroblastoma10.0SYP, NTRK1

Graphical network of the top 20 diseases related to Dysautonomia:



Diseases related to dysautonomia

Clinical Features for Dysautonomia

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Drugs & Therapeutics for Dysautonomia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Dysautonomia

Drug clinical trials:

Search ClinicalTrials for Dysautonomia

Search NIH Clinical Center for Dysautonomia

Search CenterWatch for Dysautonomia

Genetic Tests for Dysautonomia

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Anatomical Context for Dysautonomia

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32MalaCards
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MalaCards organs/tissues related to Dysautonomia:

32
Heart

Animal Models for Dysautonomia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dysautonomia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.6BDNF, FMR1, SNCA, NTRK1, DBH, IKBKAP
2MP:00053919.4HSPG2, BDNF, FMR1, NTRK1, NTRK2, DBH
3MP:00053869.0AAAS, HSPG2, BDNF, FMR1, SNCA, PRNP
4MP:00036319.0SNCA, FMR1, BDNF, HSPG2, PRNP, SYP
5MP:00053788.8HSPG2, BDNF, FMR1, SNCA, PRNP, NTRK1

Publications for Dysautonomia

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Genetic Variations for Dysautonomia

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Expression for genes affiliated with Dysautonomia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysautonomia

Search GEO for disease gene expression data for Dysautonomia.

Pathways for genes affiliated with Dysautonomia

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Dysautonomia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2NTRK2, NTRK1
210.1NTRK2, NTRK1, BDNF
310.1BDNF, NTRK1, NTRK2
410.1NTRK2, NTRK1, BDNF
59.6DBH, NTRK2, NTRK1, SYP, SNCA, FMR1

Compounds for genes affiliated with Dysautonomia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Dysautonomia according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1forskolin44 49 1112.6NTRK2, DBH
2lestaurtinib44 5911.5NTRK2, NTRK1
3ana 125910.5BDNF, NTRK1, NTRK2
4tlqp 215910.5BDNF, NTRK1, NTRK2
5bdnf (human)5910.5BDNF, NTRK1, NTRK2
6gnf 58375910.5BDNF, NTRK1, NTRK2
77,8-dihydroxyflavone44 5911.5BDNF, NTRK1, NTRK2
8pilocarpine44 28 1112.5HSPG2, BDNF, NTRK2
9k252a4410.4NTRK2, NTRK1, BDNF
10n-acetylaspartate4410.4BDNF, SYP
116-hydroxydopamine4410.4DBH, SNCA, BDNF
12mptp4410.4DBH, SNCA, BDNF
13capsaicin44 2811.3NTRK1, S100A12, BDNF, HSPG2
14kainate44 2811.3HSPG2, BDNF, SYP, NTRK2
15silver4410.3SYP, SNCA, FMR1, BDNF
16ganglioside4410.3PRNP, SYP, NTRK1
17copper44 2411.3S100A12, SNCA, PRNP, DBH
18levodopa44 1111.2BDNF, SNCA, DBH
19catecholamine4410.2BDNF, SNCA, SYP, NTRK1, DBH
20gnrh4410.2DBH, NTRK2, NTRK1, BDNF, HSPG2
21melatonin44 59 28 11 2414.2SYP, SNCA, BDNF
22dopac4410.2DBH, BDNF
23phenylalanine4410.2DBH, NTRK2, NTRK1, BDNF
24acth4410.2BDNF, SYP, DBH, AAAS
25lithium44 49 11 2413.2BDNF, FMR1, SYP, NTRK2, DBH
26pd 98,0594410.2HSPG2, BDNF, NTRK1, NTRK2, DBH
27ethanol44 49 11 2413.2BDNF, SNCA, SYP, NTRK2, DBH
28pge24410.2HSPG2, SNCA, PRNP, NTRK2, DBH
29norepinephrine44 11 2412.1BDNF, SNCA, SYP, NTRK2, DBH
30nmda44 2811.1NTRK2, SYP, BDNF
31hydrogen44 2411.1BDNF, SNCA, PRNP, SYP, DBH
32choline44 11 2412.1DBH, HSPG2, BDNF, SNCA, SYP, NTRK1
33acetylcholine44 49 28 11 2414.1HSPG2, BDNF, SNCA, SYP, NTRK1, DBH
34adenylate4410.1DBH, NTRK1, SNCA, BDNF, HSPG2
35gaba4410.1HSPG2, BDNF, FMR1, SYP, NTRK2, DBH
36dopamine44 28 11 2413.1BDNF, SNCA, SYP, NTRK1, NTRK2, DBH
37histamine44 28 2412.0HSPG2, BDNF, SYP, DBH
38alanine4410.0HSPG2, SNCA, PRNP, NTRK1, NTRK2, DBH
39h2o24410.0HSPG2, SNCA, PRNP, SYP, NTRK1, NTRK2
40testosterone44 59 11 2413.0BDNF, FMR1, SNCA, SYP, NTRK1, NTRK2
41ly294002449.9NTRK2, NTRK1, BDNF, HSPG2
42mhpg449.9DBH, BDNF
43cyclic amp44 2410.9HSPG2, BDNF, FMR1, SYP, NTRK1, NTRK2
44oxygen44 2410.9BDNF, SNCA, PRNP, NTRK1, NTRK2, DBH
45lipid449.8BDNF, SNCA, PRNP, SYP, NTRK1, NTRK2
46glutamate449.7HSPG2, BDNF, FMR1, SNCA, PRNP, SYP
47cholesterol44 28 11 2412.7BDNF, SNCA, PRNP, SYP, NTRK2
48tyrosine449.6HSPG2, BDNF, STMN2, SNCA, PRNP, SYP
49serine449.5HSPG2, BDNF, STMN2, SNCA, PRNP, SYP
50calcium44 49 11 2412.4HSPG2, BDNF, FMR1, S100A12, SNCA, PRNP

GO Terms for genes affiliated with Dysautonomia

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16Gene Ontology
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Cellular components related to Dysautonomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Elongator holoenzyme complexGO:03358810.3ELP3, IKBKAP
2presynaptic active zoneGO:04878610.2SYP, NTRK2
3excitatory synapseGO:06007610.2NTRK2, SYP
4growth coneGO:03042610.1NTRK2, SNCA, STMN2
5transcription elongation factor complexGO:00802310.0ELP3, IKBKAP
6DNA-directed RNA polymerase II, holoenzymeGO:0165919.8ELP3, IKBKAP
7cytoplasmGO:0057378.9BDNF, FMR1, S100A12, SNCA, PRNP, DBH

Biological processes related to Dysautonomia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1mechanoreceptor differentiationGO:04249010.3NTRK2, NTRK1, BDNF
2regulation of short-term neuronal synaptic plasticityGO:04817210.2SYP, BDNF
3learning or memoryGO:00761110.2NTRK1, PRNP, BDNF
4glutamate secretionGO:01404710.2NTRK2, BDNF
5negative regulation of microtubule polymerizationGO:03111510.1SNCA, STMN2
6negative regulation of neuron apoptotic processGO:04352410.1BDNF, SNCA, NTRK1, NTRK2
7positive regulation of neuron projection developmentGO:01097610.1STMN2, NTRK1, NTRK2
8agingGO:00756810.0SNCA, NTRK1, NTRK2
9positive regulation of synaptic transmission, glutamatergicGO:0519689.9NTRK2, NTRK1

Molecular functions related to Dysautonomia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphorylase kinase regulator activityGO:00860710.1ELP3, IKBKAP
2neurotrophin bindingGO:0431219.9NTRK2, NTRK1
3copper ion bindingGO:0055079.8DBH, PRNP, SNCA, S100A12

Products for genes affiliated with Dysautonomia

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  • Antibodies
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  • Lysates
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Sources for Dysautonomia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet