MCID: DYS006
MIFTS: 46

Dysembryoplastic Neuroepithelial Tumor malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Dysembryoplastic Neuroepithelial Tumor

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 61UMLS via Orphanet
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Dysembryoplastic Neuroepithelial Tumor, Aliases & Descriptions:

Name: Dysembryoplastic Neuroepithelial Tumor 9 41 11 47 60
Dysembryoplastic Neuroepithelial Neoplasm 9
 
Dnet 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
dysembryoplastic neuroepithelial tumor:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:2679
NCIt38 C9505
SNOMED-CT55 128788005
Orphanet47 251946
UMLS via Orphanet61 C1266177

Summaries for Dysembryoplastic Neuroepithelial Tumor

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MalaCards based summary: Dysembryoplastic Neuroepithelial Tumor, also known as dysembryoplastic neuroepithelial neoplasm, is related to oligodendroglioma and pilocytic astrocytoma. An important gene associated with Dysembryoplastic Neuroepithelial Tumor is SYP (synaptophysin), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Methotrexate Pathway, Pharmacokinetics. The compounds s 100 and l-amino acid have been mentioned in the context of this disorder. Affiliated tissues include cerebellum, temporal lobe and caudate nucleus, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Related Diseases for Dysembryoplastic Neuroepithelial Tumor

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Diseases related to Dysembryoplastic Neuroepithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.8OLIG2, GFAP
2pilocytic astrocytoma30.8S100B, OLIG2, SYP, NES, IDH1, GFAP
3ganglioglioma30.4SYP, GRIN1, S100B, BCL2L1, GFAP, CHGA
4glioblastoma multiforme29.9NES, GFAP, BCL2L1, MAP2, TP53
5astrocytoma29.7MAP2, MKI67, IDH1, GFAP, TP53, NES
6glioblastoma29.1MAP2, ABCG2, OLIG2, BCL2L1, GFAP, S100B
7medulloepithelioma10.6SYP
8melanotic neuroectodermal tumor10.5SYP
9giant cell glioblastoma10.5GFAP
10gliomatosis cerebri10.5GFAP
11neuronitis10.5
12pleomorphic xanthoastrocytoma10.5
13gliosarcoma10.5GFAP
14glomus tumor10.5SYP
15periventricular leukomalacia10.4NES, MYT1
16islet cell tumor10.4CHGA, SYP
17endocrine gland cancer10.4CHGA, SYP
18pineoblastoma10.4GFAP, SYP
19merkel cell carcinoma10.4CHGA, SYP
20olfactory neuroblastoma10.4SYP, S100B
21subependymal giant cell astrocytoma10.4SYP, S100B
22binswanger's disease10.4GFAP, SYP
23ganglioneuroblastoma10.4S100B, SYP
24granular cell tumor10.4SYP, S100B
25temporal lobe epilepsy10.3
26focal epilepsy10.3
27chiari malformation10.3
28hemimegalencephaly10.3
29neuronal migration disorders10.3
30angiocentric glioma10.3
31rosette-forming glioneuronal tumour of the fourth ventricule10.3
32gemistocytic astrocytoma10.3GFAP, S100B
33myxopapillary ependymoma10.3S100B, GFAP
34anaplastic oligodendroglioma10.3OLIG2, GFAP
35choroid plexus carcinoma10.3S100B, GFAP
36anaplastic ependymoma10.3GFAP, S100B
37tubular adenocarcinoma10.3CHGA, SYP
38papilloma10.3TP53
39neuroectodermal tumor10.3BCL2L1, SYP
40syringoma10.3GFAP, S100B
41myoepithelioma10.3GFAP, S100B
42ewing sarcoma10.3CHGA, S100B, NES
43papillary ependymoma10.3S100B, SYP, GFAP
44neuroblastoma10.2SYP, TP53
45neuroendocrine tumor10.2CHGA
46neurilemmoma10.2S100B, NES, GFAP
47adrenal cortical adenoma10.2CHGA, MKI67, SYP
48papillary carcinoma10.2SYP, MKI67, CHGA
49brain disease10.2MAP2, GFAP, SYP
50hemangioblastoma10.1GFAP, NES, SYP, S100B

Graphical network of the top 20 diseases related to Dysembryoplastic Neuroepithelial Tumor:



Diseases related to dysembryoplastic neuroepithelial tumor

Symptoms for Dysembryoplastic Neuroepithelial Tumor

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Drugs & Therapeutics for Dysembryoplastic Neuroepithelial Tumor

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Drug clinical trials:

Search ClinicalTrials for Dysembryoplastic Neuroepithelial Tumor

Search NIH Clinical Center for Dysembryoplastic Neuroepithelial Tumor

Genetic Tests for Dysembryoplastic Neuroepithelial Tumor

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Anatomical Context for Dysembryoplastic Neuroepithelial Tumor

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MalaCards organs/tissues related to Dysembryoplastic Neuroepithelial Tumor:

31
Cerebellum, Temporal lobe, Caudate nucleus, Brain, Cortex, Parietal lobe

Animal Models for Dysembryoplastic Neuroepithelial Tumor or affiliated genes

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MGI Mouse Phenotypes related to Dysembryoplastic Neuroepithelial Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.9MYT1, CHGA, PSIP1, MAP2, BCL2L1, TP53
2MP:00053767.7ABCC2, ABCG2, IDH1, GFAP, TP53, MYT1
3MP:00036317.6ABCG2, GFAP, TP53, NES, SYP, MAP2
4MP:00053867.1GRIN1, GFAP, TP53, NES, PSIP1, MAP2
5MP:00053787.0GFAP, TP53, NES, CHGA, PSIP1, MAP2
6MP:00107686.8GFAP, TP53, MYT1, NES, CHGA, PSIP1
7MP:00053846.6ABCC5, GFAP, TP53, NES, PSIP1, BCL2L1

Publications for Dysembryoplastic Neuroepithelial Tumor

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Articles related to Dysembryoplastic Neuroepithelial Tumor:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Dysembryoplastic neuroepithelial tumor, a pure glial tumor? Immunohistochemical and morphometric studies. (23530928)
2013
2
Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature. (24137435)
2013
3
Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. (23442159)
2013
4
Electrocorticographic-histopathologic correlations implying epileptogenicity of dysembryoplastic neuroepithelial tumor. (24077279)
2013
5
Dysembryoplastic Neuroepithelial Tumor: A Clinical, Neuroradiological, and Pathological Study of 15 Cases. (23752069)
2013
6
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
7
Focal epilepsy associated with dysembryoplastic neuroepithelial tumor in the area of the caudate nucleus. (22809555)
2012
8
Dysembryoplastic neuroepithelial tumor originally diagnosed as astrocytoma and oligodendroglioma. (22990729)
2012
9
Intraventricular dysembryoplastic neuroepithelial tumor in a pediatric patient: is it the most common extracortical location for DNT? (20959995)
2011
10
Lhermitte-Duclos disease associated with dysembryoplastic neuroepithelial tumor differentiation with characteristic magnetic resonance appearance of "tiger striping". (21704939)
2011
11
A patient with a dysembryoplastic neuroepithelial tumor who underwent epilepsy surgery after initial seizure. (22777137)
2011
12
Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients. (20043747)
2010
13
F-18 FDG-PET imaging of dysembryoplastic neuroepithelial tumor-like astrocytoma. (19893407)
2009
14
Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature. (19267228)
2009
15
Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor. (19263357)
2009
16
Dysembryoplastic neuroepithelial tumor: a clinicopathological study of 32 cases. (19165515)
2009
17
Editorial. Dysembryoplastic neuroepithelial tumor. (19485726)
2009
18
Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. (19485727)
2009
19
Familial occurrence of dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: case report. (18797318)
2008
20
Electroencephalography-guided resection of dysembryoplastic neuroepithelial tumor: case report. (18654053)
2008
21
Recurrence of dysembryoplastic neuroepithelial tumor following resection. (18552517)
2008
22
Gamma knife radiosurgery for epilepsy related to dysembryoplastic neuroepithelial tumor. (17063046)
2006
23
Endoscopic resection of an intraventricular dysembryoplastic neuroepithelial tumor of the septum pellucidum. (16465080)
2006
24
A nonspecific form of dysembryoplastic neuroepithelial tumor presenting with intractable epilepsy. (18095102)
2005
25
Perfusion MR imaging and proton MR spectroscopy in a case of dysembryoplastic neuroepithelial tumor. (16098271)
2005
26
Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor. (15921242)
2005
27
Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy. (14692906)
2004
28
Dysembryoplastic neuroepithelial tumor in the left lateral ventricle. (14628248)
2003
29
Dysembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. (12920757)
2003
30
Dysembryoplastic neuroepithelial tumor or dysembryoplastic cortical neurocytoma? (12777091)
2003
31
Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy. (12913847)
2003
32
A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor? (11979088)
2002
33
Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disorders. (12423388)
2002
34
Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: a lesion often misdiagnosed as glioma: report of 10 cases. (11257624)
2001
35
Bcl-2, bcl-x, and bax expression in dysembryoplastic neuroepithelial tumors. (10749285)
2000
36
Dysembryoplastic neuroepithelial tumor of the cerebellum and brainstem. Case report. (10969950)
2000
37
Dysembryoplastic neuroepithelial tumor: radiological findings (including PET, SPECT, and MRS) and surgical strategy. (10982159)
2000
38
A case of an unclassified tumor closely resembling dysembryoplastic neuroepithelial tumor with rapid growth. (10982009)
2000
39
Dysembryoplastic neuroepithelial tumor. (10087102)
1999
40
Infratentorial dysembryoplastic neuroepithelial tumor (DNT) associated with Arnold-Chiari malformation. (9832257)
1998
41
Mixed dysembryoplastic neuroepithelial tumor and ganglioglioma. (9650758)
1998
42
Dysembryoplastic neuroepithelial tumor and oligodendroglioma: the diagnostic value of magnetic resonance spectroscopy. Case report and review of the literature. (17168506)
1998
43
Dysembryoplastic neuroepithelial tumor. Case report]. (9629369)
1997
44
Neural antigens in oligodendrogliomas and dysembryoplastic neuroepithelial tumors. (9386775)
1997
45
Mesial temporal dysembryoplastic neuroepithelial tumor mimicking oligodendroglioma: a case report and review of the literature. (9041772)
1996
46
A case of dysembryoplastic neuroepithelial tumor of the parietal lobe with characteristic magnetic resonance imaging. (8677797)
1996
47
How would you treat this patient? Dysembryoplastic neuroepithelial tumor. (8677483)
1996
48
Clinical, radiological and histological presentations of dysembryoplastic neuroepithelial tumors (DNT). Report of two cases. (9812423)
1996
49
Dysembryoplastic neuroepithelial tumor: report of a case without typical glioneuronal elements. (7754749)
1995
50
Radiologic appearance of the dysembryoplastic neuroepithelial tumor. (7568829)
1995

Variations for Dysembryoplastic Neuroepithelial Tumor

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Expression for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Search GEO for disease gene expression data for Dysembryoplastic Neuroepithelial Tumor.

Pathways for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Pathways related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ABCC2, ABCG2
2
Show member pathways
9.9ABCC2, ABCG2
3
Show member pathways
9.9ABCG2, ABCC2
49.9ABCG2, ABCC2
59.6GRIN1, TP53, GFAP
6
Show member pathways
9.6ABCC2, ABCG2, MAP2
79.5ABCG2, ABCC5
89.5ABCG2, ABCC5
9
Show member pathways
9.5TP53, ABCG2, ABCC2
10
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.3TP53, BCL2L1, GRIN1
11
Show member pathways
9.3ABCG2, ABCC2, ABCC5
12
Show member pathways
9.1TP53, ABCG2, ABCC5
138.0GRIN1, MKI67, GFAP, PSIP1, SYP, MAP2

Compounds for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Compounds related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 161)
idCompoundScoreTop Affiliating Genes
1s 100439.9SYP, GFAP, CHGA, S100B
2l-amino acid439.8SYP, MAP2, S100B, CHGA
3streptozotocin439.8SYP, CHGA, NES, GFAP
4reticulin439.7GFAP, S100B, SYP
5kainate43 2810.6SYP, MAP2, NES, GFAP, GRIN1
6methanol43 2410.5CHGA, MAP2, MKI67, GFAP
7silver439.4GFAP, MKI67, CHGA, SYP, MAP2
83-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.4ABCC2, S100B, BCL2L1, MAP2
9formaldehyde43 2410.3MKI67, SYP, CHGA, S100B, GFAP
10ganglioside439.3NES, MAP2, GFAP, SYP
11topotecan43 1210.3BCL2L1, TP53, ABCC2, ABCG2
12fluorouracil49 1210.2ABCC2, ABCC5, ABCG2, TP53
13hematoxylin439.2S100B, MAP2, SYP, CHGA, MKI67, GFAP
14gaba439.1CHGA, NES, GRIN1, S100B, MAP2, SYP
15ethanol43 49 24 1212.1MKI67, SYP, MAP2, S100B, GRIN1, GFAP
16dutp439.1BCL2L1, MKI67, GFAP, TP53, SYP
17dopamine43 28 24 1212.1SYP, MAP2, S100B, GRIN1, CHGA, NES
18oxaliplatin43 49 1211.1BCL2L1, TP53, ABCG2, ABCC2
19dbc-amp439.1SYP, GFAP, MAP2, S100B
20glutamine439.0SYP, ABCG2, GFAP, GRIN1, S100B, IDH1
21vinblastine43 49 1211.0MAP2, ABCC2, ABCG2, TP53, BCL2L1
22glycogen43 2410.0SYP, MKI67, CHGA, S100B, MAP2, GFAP
23irinotecan43 49 1211.0ABCC2, BCL2L1, TP53, MKI67, ABCG2
24docetaxel43 49 59 1212.0BCL2L1, ABCG2, TP53, MAP2, ABCC2
25bromodeoxyuridine438.8S100B, ABCG2, MAP2, CHGA, NES, MKI67
26nitric oxide43 24 1210.8CHGA, MAP2, S100B, GRIN1, ABCC2, MKI67
27testosterone43 59 24 1211.7SYP, CHGA, S100B, GFAP, ABCG2, MKI67
28choline43 24 1210.7S100B, MAP2, SYP, PSIP1, GFAP, NES
29adriamycin438.7BCL2L1, TP53, ABCG2, ABCC2, ABCC5
30etoposide43 49 59 1211.7ABCC2, ABCG2, TP53, CHGA, SYP, BCL2L1
31vincristine43 49 1210.7ABCG2, MKI67, TP53, MAP2, BCL2L1, ABCC2
32glutamate438.6SYP, NES, GFAP, IDH1, ABCC2, GRIN1
33dexamethasone43 49 28 1211.5BCL2L1, S100B, CHGA, ABCC2, GFAP, ABCG2
34cycloheximide438.5ABCC2, MKI67, GFAP, TP53, GRIN1, BCL2L1
35lipid438.5GRIN1, SYP, CHGA, ABCG2, S100B, NES
365fluorouracil438.4ABCC2, ABCG2, TP53, BCL2L1, ABCC5, MKI67
37arginine438.3ABCC2, TP53, MKI67, CHGA, GFAP, ABCG2
38doxorubicin43 49 1210.2ABCC2, ABCG2, ABCC5, BCL2L1, TP53, MKI67
39oxygen43 249.1BCL2L1, GRIN1, S100B, ABCC2, MKI67, GFAP
40paraffin438.0TP53, CHGA, SYP, MAP2, BCL2L1, S100B
41vegf438.0S100B, BCL2L1, GFAP, MKI67, NES, TP53
42progesterone43 28 59 24 1212.0NES, S100B, MKI67, SYP, MAP2, CHGA
43atp43 288.9ABCC2, ABCC5, GFAP, ABCG2, CHGA, MAP2
44paclitaxel43 49 129.9CHGA, GFAP, BCL2L1, S100B, MKI67, MAP2
45serine437.8GFAP, MKI67, GRIN1, TP53, BCL2L1, CHGA
46cisplatin43 49 59 1210.7ABCG2, MKI67, SYP, GFAP, CHGA, ABCC2
47estrogen437.5ABCG2, MKI67, ABCC2, S100B, BCL2L1, MAP2
48calcium43 49 24 1210.3GFAP, IDH1, MKI67, PSIP1, CHGA, ABCG2
49retinoic acid43 248.1MAP2, ABCC2, MKI67, GFAP, TP53, NES
50tyrosine436.8BCL2L1, MAP2, GRIN1, PSIP1, CHGA, ABCC2

GO Terms for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Cellular components related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:00600769.8GRIN1, SYP
2nuclear peripheryGO:00343999.2MAP2, PSIP1
3cytoplasmGO:00057377.4IDH1, GFAP, TP53, NES, MAP2, BCL2L1

Biological processes related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:000685510.2ABCG2, ABCC2
2regulation of neuronal synaptic plasticityGO:004816810.1S100B, SYP
3regulation of long-term neuronal synaptic plasticityGO:004816910.1SYP, GRIN1
4cellular response to organic substanceGO:007131010.0MAP2, SYP
5long-term synaptic potentiationGO:00602919.8S100B, GFAP
6regulation of mitochondrial membrane permeabilityGO:00469029.8BCL2L1, TP53
7central nervous system developmentGO:00074179.7TP53, NES, S100B
8negative regulation of neuron apoptotic processGO:00435249.6GRIN1, BCL2L1, NES
9release of cytochrome c from mitochondriaGO:00018369.5BCL2L1, TP53
10response to oxidative stressGO:00069799.4ABCC2, IDH1, PSIP1
11positive regulation of apoptotic processGO:00430659.3GRIN1, S100B, BCL2L1, TP53
12hyaluronan metabolic processGO:00302129.2MKI67, ABCC5
13cell proliferationGO:00082839.1S100B, BCL2L1, TP53, MKI67

Molecular functions related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:00085149.3ABCC2, ABCC5
2ATPase activity, coupled to transmembrane movement of substancesGO:00426269.3ABCG2, ABCC2, ABCC5
3identical protein bindingGO:00428029.1S100B, BCL2L1, SYP, TP53
4protein homodimerization activityGO:00428038.6ABCG2, IDH1, BCL2L1, OLIG2, S100B

Products for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Sources for Dysembryoplastic Neuroepithelial Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet