DNET
MCID: DYS006
MIFTS: 54

Dysembryoplastic Neuroepithelial Tumor (DNET) malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Dysembryoplastic Neuroepithelial Tumor

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66Wikipedia, 34MalaCards
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Wikipedia:66 Dysembryoplastic neuroepithelial tumour, commonly abbreviated DNT or DNET, is a type of brain tumour. more...

MalaCards: Dysembryoplastic Neuroepithelial Tumor, also known as dysembryoplastic neuroepithelial neoplasm, is related to oligodendroglioma and ganglioglioma. An important gene associated with Dysembryoplastic Neuroepithelial Tumor is SYP (synaptophysin), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Statin Pathway - Generalized, Pharmacokinetics. The compounds s 100 and l-amino acid have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and caudate nucleus, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Aliases & Classifications for Dysembryoplastic Neuroepithelial Tumor

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 41NCIt, 59SNOMED-CT, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
dysembryoplastic neuroepithelial tumor:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

dysembryoplastic neuroepithelial tumor 9 44 11 50 63
dysembryoplastic neuroepithelial neoplasm 9
dnet 50


External Ids:

Disease Ontology9 DOID:2679
NCIt41 C9505
SNOMED-CT59 128788005
SNOMED-CT via Orphanet60 128788005
UMLS via Orphanet64 C1266177

Related Diseases for Dysembryoplastic Neuroepithelial Tumor

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18GeneCards, 19GeneDecks
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Diseases related to Dysembryoplastic Neuroepithelial Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.3GFAP, OLIG2
2ganglioglioma30.8GRIN1, S100B, GFAP, CHGA, SYP, MAP2
3pilocytic astrocytoma30.7IDH1, GFAP, NES, SYP, OLIG2, S100B
4astrocytoma30.6MKI67, IDH1, GFAP, TP53, NES, SYP
5glioblastoma multiforme30.3GFAP, TP53, NES, MAP2, BCL2L1
6neuronitis10.5
7rosette-forming glioneuronal tumour of the fourth ventricule10.5
8temporal lobe epilepsy10.3
9pleomorphic xanthoastrocytoma10.3
10focal epilepsy10.3
11chiari malformation10.3
12hemimegalencephaly10.3
13neuronal migration disorders10.3
14medulloepithelioma10.1SYP
15melanotic neuroectodermal tumor10.1SYP
16giant cell glioblastoma10.1GFAP
17gliomatosis cerebri10.1GFAP
18gliosarcoma10.1GFAP
19glomus tumor10.1SYP
20periventricular leukomalacia10.1NES, MYT1
21pancreatic islet cell tumors10.1CHGA, SYP
22endocrine gland cancer10.1SYP, CHGA
23pineoblastoma10.1GFAP, SYP
24merkel cell carcinoma10.1CHGA, SYP
25olfactory neuroblastoma10.1S100B, SYP
26subependymal giant cell astrocytoma10.1S100B, SYP
27binswanger's disease10.1SYP, GFAP
28neuroendocrine tumor10.1CHGA
29granular cell tumor10.1SYP, S100B
30ganglioneuroblastoma10.1SYP, S100B
31gemistocytic astrocytoma10.1GFAP, S100B
32myxopapillary ependymoma10.1S100B, GFAP
33anaplastic oligodendroglioma10.1OLIG2, GFAP
34choroid plexus carcinoma10.1S100B, GFAP
35anaplastic ependymoma10.1S100B, GFAP
36tubular adenocarcinoma10.1CHGA, SYP
37papilloma10.1TP53
38neuroepithelioma10.1SYP, BCL2L1
39syringoma10.1S100B, GFAP
40myoepithelioma10.1GFAP, S100B
41peripheral primitive neuroectodermal tumor10.1S100B, CHGA, NES
42papillary ependymoma10.1S100B, SYP, GFAP
43neuroblastoma10.1SYP, TP53
44neurilemmoma10.0GFAP, NES, S100B
45adrenal adenoma10.0MKI67, CHGA, SYP
46papillary carcinoma10.0SYP, CHGA, MKI67
47prion disease10.0GFAP, SYP, MAP2
48hemangioblastoma10.0GFAP, NES, SYP, S100B
49pineocytoma10.0GFAP, CHGA, SYP, S100B
50ganglioneuroma10.0GFAP, CHGA, SYP, S100B

Graphical network of the top 20 diseases related to Dysembryoplastic Neuroepithelial Tumor:



Diseases related to dysembryoplastic neuroepithelial tumor

Symptoms for Dysembryoplastic Neuroepithelial Tumor

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Drugs & Therapeutics for Dysembryoplastic Neuroepithelial Tumor

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Dysembryoplastic Neuroepithelial Tumor

Drug clinical trials:

Search ClinicalTrials for Dysembryoplastic Neuroepithelial Tumor

Search NIH Clinical Center for Dysembryoplastic Neuroepithelial Tumor

Search CenterWatch for Dysembryoplastic Neuroepithelial Tumor

Genetic Tests for Dysembryoplastic Neuroepithelial Tumor

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Anatomical Context for Dysembryoplastic Neuroepithelial Tumor

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34MalaCards
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MalaCards organs/tissues related to Dysembryoplastic Neuroepithelial Tumor:

34
Brain, Temporal lobe, Caudate nucleus, Cortex, Cerebellum, Parietal lobe

Animal Models for Dysembryoplastic Neuroepithelial Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Dysembryoplastic Neuroepithelial Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.9MYT1, CHGA, PSIP1, MAP2, BCL2L1, TP53
2MP:00053767.7ABCC2, ABCG2, IDH1, GFAP, TP53, MYT1
3MP:00036317.6ABCG2, GFAP, TP53, NES, SYP, MAP2
4MP:00053867.1GRIN1, GFAP, TP53, NES, PSIP1, MAP2
5MP:00053787.0GFAP, TP53, NES, CHGA, PSIP1, MAP2
6MP:00107686.8GFAP, TP53, MYT1, NES, CHGA, PSIP1
7MP:00053846.6ABCC5, GFAP, TP53, NES, PSIP1, BCL2L1

Publications for Dysembryoplastic Neuroepithelial Tumor

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53PubMed
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Articles related to Dysembryoplastic Neuroepithelial Tumor:

(show top 50)    (show all 107)
idTitleAuthorsYear
1
Dysembryoplastic neuroepithelial tumor, a pure glial tumor? Immunohistochemical and morphometric studies. (23530928)
2013
2
Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature. (24137435)
2013
3
Electrocorticographic-histopathologic correlations implying epileptogenicity of dysembryoplastic neuroepithelial tumor. (24077279)
2013
4
Dysembryoplastic Neuroepithelial Tumor: A Clinical, Neuroradiological, and Pathological Study of 15 Cases. (23752069)
2013
5
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
6
Focal epilepsy associated with dysembryoplastic neuroepithelial tumor in the area of the caudate nucleus. (22809555)
2012
7
Dysembryoplastic neuroepithelial tumor originally diagnosed as astrocytoma and oligodendroglioma. (22990729)
2012
8
Intraventricular dysembryoplastic neuroepithelial tumor in a pediatric patient: is it the most common extracortical location for DNT? (20959995)
2011
9
Lhermitte-Duclos disease associated with dysembryoplastic neuroepithelial tumor differentiation with characteristic magnetic resonance appearance of "tiger striping". (21704939)
2011
10
A patient with a dysembryoplastic neuroepithelial tumor who underwent epilepsy surgery after initial seizure. (22777137)
2011
11
F-18 FDG-PET imaging of dysembryoplastic neuroepithelial tumor-like astrocytoma. (19893407)
2009
12
Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature. (19267228)
2009
13
Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor. (19263357)
2009
14
Dysembryoplastic neuroepithelial tumor: a clinicopathological study of 32 cases. (19165515)
2009
15
Editorial. Dysembryoplastic neuroepithelial tumor. (19485726)
2009
16
Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. (19485727)
2009
17
Familial occurrence of dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: case report. (18797318)
2008
18
Electroencephalography-guided resection of dysembryoplastic neuroepithelial tumor: case report. (18654053)
2008
19
Recurrence of dysembryoplastic neuroepithelial tumor following resection. (18552517)
2008
20
Dysembryoplastic neuroepithelial tumor of the brainstem. (24256828)
2008
21
Gamma knife radiosurgery for epilepsy related to dysembryoplastic neuroepithelial tumor. (17063046)
2006
22
Endoscopic resection of an intraventricular dysembryoplastic neuroepithelial tumor of the septum pellucidum. (16465080)
2006
23
Frequent association of cortical dysplasia in dysembryoplastic neuroepithelial tumor treated by epilepsy surgery. (16253690)
2005
24
A nonspecific form of dysembryoplastic neuroepithelial tumor presenting with intractable epilepsy. (18095102)
2005
25
Perfusion MR imaging and proton MR spectroscopy in a case of dysembryoplastic neuroepithelial tumor. (16098271)
2005
26
Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor. (15921242)
2005
27
Usefulness of [11C]methionine PET in the diagnosis of dysembryoplastic neuroepithelial tumor with temporal lobe epilepsy. (14692906)
2004
28
Dysembryoplastic neuroepithelial tumor in the left lateral ventricle. (14628248)
2003
29
Dysembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. (12920757)
2003
30
Dysembryoplastic neuroepithelial tumor or dysembryoplastic cortical neurocytoma? (12777091)
2003
31
Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy. (12913847)
2003
32
A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor? (11979088)
2002
33
Various findings in surgically treated epilepsy patients with dysembryoplastic neuroepithelial tumors in comparison with those of patients with other low-grade brain tumors and other neuronal migration disorders. (12423388)
2002
34
Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: a lesion often misdiagnosed as glioma: report of 10 cases. (11257624)
2001
35
Bcl-2, bcl-x, and bax expression in dysembryoplastic neuroepithelial tumors. (10749285)
2000
36
Dysembryoplastic neuroepithelial tumor of the cerebellum and brainstem. Case report. (10969950)
2000
37
Dysembryoplastic neuroepithelial tumor: radiological findings (including PET, SPECT, and MRS) and surgical strategy. (10982159)
2000
38
A case of an unclassified tumor closely resembling dysembryoplastic neuroepithelial tumor with rapid growth. (10982009)
2000
39
Dysembryoplastic neuroepithelial tumor. (10087102)
1999
40
Infratentorial dysembryoplastic neuroepithelial tumor (DNT) associated with Arnold-Chiari malformation. (9832257)
1998
41
Mixed dysembryoplastic neuroepithelial tumor and ganglioglioma. (9650758)
1998
42
Dysembryoplastic neuroepithelial tumor and oligodendroglioma: the diagnostic value of magnetic resonance spectroscopy. Case report and review of the literature. (17168506)
1998
43
Dysembryoplastic neuroepithelial tumor. Case report]. (9629369)
1997
44
Neural antigens in oligodendrogliomas and dysembryoplastic neuroepithelial tumors. (9386775)
1997
45
Mesial temporal dysembryoplastic neuroepithelial tumor mimicking oligodendroglioma: a case report and review of the literature. (9041772)
1996
46
A case of dysembryoplastic neuroepithelial tumor of the parietal lobe with characteristic magnetic resonance imaging. (8677797)
1996
47
How would you treat this patient? Dysembryoplastic neuroepithelial tumor. (8677483)
1996
48
Clinical, radiological and histological presentations of dysembryoplastic neuroepithelial tumors (DNT). Report of two cases. (9812423)
1996
49
Dysembryoplastic neuroepithelial tumor: report of a case without typical glioneuronal elements. (7754749)
1995
50
Radiologic appearance of the dysembryoplastic neuroepithelial tumor. (7568829)
1995

Variations for Dysembryoplastic Neuroepithelial Tumor

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Expression for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

Search GEO for disease gene expression data for Dysembryoplastic Neuroepithelial Tumor.

Pathways for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Sources:
51PathCards, 52PharmGKB, 13EMD Millipore, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 56Reactome, 5Cell Signaling Technology
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Pathways related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ABCC2, ABCG2
2
Show member pathways
9.9ABCC2, ABCG2
3
Show member pathways
9.9ABCG2, ABCC2
49.9ABCG2, ABCC2
5
Show member pathways
Cytoskeleton remodeling Neurofilaments61
9.6NES, GFAP, MAP2
69.6GRIN1, TP53, GFAP
7
Show member pathways
9.6MAP2, ABCG2, ABCC2
89.5ABCG2, ABCC5
99.5ABCG2, ABCC5
10
Show member pathways
9.5ABCC2, ABCG2, TP53
11
Show member pathways
Amyotrophic lateral sclerosis (ALS)39
9.3GRIN1, BCL2L1, TP53
12
Show member pathways
9.3ABCG2, ABCC2, ABCC5
13
Show member pathways
9.1TP53, ABCG2, ABCC5
148.0GRIN1, MKI67, GFAP, PSIP1, SYP, MAP2

Compounds for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 161)
idCompoundScoreTop Affiliating Genes
1s 100469.9SYP, GFAP, CHGA, S100B
2l-amino acid469.8SYP, MAP2, S100B, CHGA
3streptozotocin469.8SYP, CHGA, NES, GFAP
4reticulin469.7GFAP, S100B, SYP
5kainate46 3010.6SYP, MAP2, NES, GFAP, GRIN1
6methanol46 2510.5CHGA, MAP2, MKI67, GFAP
7silver469.4GFAP, MKI67, CHGA, SYP, MAP2
83-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.4ABCC2, S100B, BCL2L1, MAP2
9formaldehyde46 2510.3MKI67, SYP, CHGA, S100B, GFAP
10ganglioside469.3NES, MAP2, GFAP, SYP
11topotecan46 1210.3BCL2L1, TP53, ABCC2, ABCG2
12fluorouracil52 1210.2ABCC2, ABCC5, ABCG2, TP53
13hematoxylin469.2S100B, MAP2, SYP, CHGA, MKI67, GFAP
14gaba469.1CHGA, NES, GRIN1, S100B, MAP2, SYP
15ethanol46 52 25 1212.1MKI67, SYP, MAP2, S100B, GRIN1, GFAP
16dutp469.1BCL2L1, MKI67, GFAP, TP53, SYP
17dopamine46 30 25 1212.1SYP, MAP2, S100B, GRIN1, CHGA, NES
18oxaliplatin46 52 1211.1BCL2L1, TP53, ABCG2, ABCC2
19dbc-amp469.1SYP, GFAP, MAP2, S100B
20glutamine469.0SYP, ABCG2, GFAP, GRIN1, S100B, IDH1
21vinblastine46 52 1211.0MAP2, ABCC2, ABCG2, TP53, BCL2L1
22glycogen46 2510.0SYP, MKI67, CHGA, S100B, MAP2, GFAP
23irinotecan46 52 1211.0ABCC2, BCL2L1, TP53, MKI67, ABCG2
24docetaxel46 52 62 1212.0BCL2L1, ABCG2, TP53, MAP2, ABCC2
25bromodeoxyuridine468.8S100B, ABCG2, MAP2, CHGA, NES, MKI67
26nitric oxide46 25 1210.8CHGA, MAP2, S100B, GRIN1, ABCC2, MKI67
27testosterone46 62 25 1211.7SYP, CHGA, S100B, GFAP, ABCG2, MKI67
28choline46 25 1210.7S100B, MAP2, SYP, PSIP1, GFAP, NES
29adriamycin468.7BCL2L1, TP53, ABCG2, ABCC2, ABCC5
30etoposide46 52 62 1211.7ABCC2, ABCG2, TP53, CHGA, SYP, BCL2L1
31vincristine46 52 1210.7ABCG2, MKI67, TP53, MAP2, BCL2L1, ABCC2
32glutamate468.6SYP, NES, GFAP, IDH1, ABCC2, GRIN1
33dexamethasone46 52 30 1211.5BCL2L1, S100B, CHGA, ABCC2, GFAP, ABCG2
34cycloheximide468.5ABCC2, MKI67, GFAP, TP53, GRIN1, BCL2L1
35lipid468.5GRIN1, SYP, CHGA, ABCG2, S100B, NES
365fluorouracil468.4ABCC2, ABCG2, TP53, BCL2L1, ABCC5, MKI67
37arginine468.3ABCC2, TP53, MKI67, CHGA, GFAP, ABCG2
38doxorubicin46 52 1210.2ABCC2, ABCG2, ABCC5, BCL2L1, TP53, MKI67
39oxygen46 259.1BCL2L1, GRIN1, S100B, ABCC2, MKI67, GFAP
40paraffin468.0TP53, CHGA, SYP, MAP2, BCL2L1, S100B
41vegf468.0S100B, BCL2L1, GFAP, MKI67, NES, TP53
42progesterone46 30 62 25 1212.0NES, S100B, MKI67, SYP, MAP2, CHGA
43atp46 308.9ABCC2, ABCC5, GFAP, ABCG2, CHGA, MAP2
44paclitaxel46 52 129.9CHGA, GFAP, BCL2L1, S100B, MKI67, MAP2
45serine467.8GFAP, MKI67, GRIN1, TP53, BCL2L1, CHGA
46cisplatin46 52 62 1210.7ABCG2, MKI67, SYP, GFAP, CHGA, ABCC2
47estrogen467.5ABCG2, MKI67, ABCC2, S100B, BCL2L1, MAP2
48calcium46 52 25 1210.3GFAP, IDH1, MKI67, PSIP1, CHGA, ABCG2
49retinoic acid46 258.1MAP2, ABCC2, MKI67, GFAP, TP53, NES
50tyrosine466.8BCL2L1, MAP2, GRIN1, PSIP1, CHGA, ABCC2

GO Terms for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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17Gene Ontology
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Cellular components related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.8GRIN1, SYP
2nuclear peripheryGO:0343999.2MAP2, PSIP1
3cytoplasmGO:0057377.4IDH1, GFAP, TP53, NES, MAP2, BCL2L1

Biological processes related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:00685510.2ABCG2, ABCC2
2regulation of neuronal synaptic plasticityGO:04816810.1S100B, SYP
3regulation of long-term neuronal synaptic plasticityGO:04816910.1SYP, GRIN1
4cellular response to organic substanceGO:07131010.0MAP2, SYP
5long-term synaptic potentiationGO:0602919.8S100B, GFAP
6regulation of mitochondrial membrane permeabilityGO:0469029.8BCL2L1, TP53
7central nervous system developmentGO:0074179.7TP53, NES, S100B
8negative regulation of neuron apoptotic processGO:0435249.6GRIN1, BCL2L1, NES
9release of cytochrome c from mitochondriaGO:0018369.5BCL2L1, TP53
10response to oxidative stressGO:0069799.4ABCC2, IDH1, PSIP1
11positive regulation of apoptotic processGO:0430659.3GRIN1, S100B, BCL2L1, TP53
12hyaluronan metabolic processGO:0302129.2MKI67, ABCC5
13cell proliferationGO:0082839.1S100B, BCL2L1, TP53, MKI67

Molecular functions related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:0085149.3ABCC2, ABCC5
2ATPase activity, coupled to transmembrane movement of substancesGO:0426269.3ABCG2, ABCC2, ABCC5
3identical protein bindingGO:0428029.1S100B, BCL2L1, SYP, TP53
4protein homodimerization activityGO:0428038.6ABCG2, IDH1, BCL2L1, OLIG2, S100B

Products for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Sources for Dysembryoplastic Neuroepithelial Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet