DNET
MCID: DYS006
MIFTS: 48

Dysembryoplastic Neuroepithelial Tumor (DNET) malady

Neuronal diseases, Cancer diseases categories

Summaries for Dysembryoplastic Neuroepithelial Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dysembryoplastic neuroepithelial tumour, commonly abbreviated DNT or DNET, is a type of brain tumour. more...

MalaCards: Dysembryoplastic Neuroepithelial Tumor, also known as dysembryoplastic neuroepithelial neoplasm, is related to oligodendroglioma and ganglioglioma. An important gene associated with Dysembryoplastic Neuroepithelial Tumor is SYP (synaptophysin), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Pravastatin Pathway, Pharmacokinetics. The compounds s 100 and reticulin have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and temporal lobe, and related mouse phenotype nervous system.

Aliases & Classifications for Dysembryoplastic Neuroepithelial Tumor

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
dysembryoplastic neuroepithelial tumor:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

dysembryoplastic neuroepithelial tumor 8 42 10 48 60
dysembryoplastic neuroepithelial neoplasm 8
dnet 48


External Ids:

Disease Ontology8 DOID:2679
NCIt39 C9505
SNOMED-CT56 128788005
SNOMED-CT via Orphanet57 128788005

Related Diseases for Dysembryoplastic Neuroepithelial Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Dysembryoplastic Neuroepithelial Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1oligodendroglioma31.1OLIG2, GFAP
2ganglioglioma30.8S100B, SYP, CHGA, GRIN1, MAP2, GFAP
3astrocytoma30.8IDH1, S100B, MVP, NES, SYP, MAP2
4glioblastoma multiforme30.4NES, MAP2, GFAP, BCL2L1
5neuronitis10.4
6rosette-forming glioneuronal tumour of the fourth ventricule10.4
7temporal lobe epilepsy10.3
8pleomorphic xanthoastrocytoma10.3
9focal epilepsy10.3
10neuroblastoma10.0SYP
11medulloepithelioma10.0SYP
12rhabdoid tumor10.0SYP
13parkinson's disease10.0NES
14phaeochromocytoma10.0CHGA
15chondrosarcoma10.0S100B
16hepatitis10.0ABCC2
17dermatofibrosarcoma protuberans10.0S100B
18melanotic neuroectodermal tumor10.0SYP
19parathyroid adenoma10.0CHGA
20thyroid cancer10.0CHGA
21giant cell glioblastoma10.0GFAP
22granular cell tumor10.0SYP, S100B
23gliomatosis cerebri10.0GFAP
24ganglioneuroblastoma10.0SYP, S100B
25gliosarcoma10.0GFAP
26down syndrome10.0S100B
27merkel cell carcinoma10.0CHGA, SYP
28cervical cancer10.0MAP2
29subependymal giant cell astrocytoma10.0SYP, S100B
30olfactory neuroblastoma10.0SYP, S100B
31neurofibroma10.0SYP, S100B
32myeloid leukemia10.0BCL2L1
33periventricular leukomalacia10.0NES, MYT1
34binswanger's disease10.0SYP, GFAP
35myxopapillary ependymoma10.0GFAP, S100B
36endocrine gland cancer10.0SYP, CHGA
37choroid plexus carcinoma10.0GFAP, S100B
38anaplastic ependymoma10.0GFAP, S100B
39gemistocytic astrocytoma10.0GFAP, S100B
40papillary ependymoma10.0GFAP, SYP, S100B
41choroid plexus papilloma10.0S100B, SYP, GFAP
42malignant mesothelioma10.0BCL2L1, ABCC2
43toxic encephalopathy10.0GFAP, MAP2
44bipolar disorder10.0GRIN1, MAP2
45peripheral primitive neuroectodermal tumor10.0CHGA, NES, S100B
46chordoma10.0S100B, GFAP
47encephalitis10.0GFAP
48dubin-johnson syndrome10.0ABCC2
49pheochromocytoma10.0SYP, CHGA, MAP2
50colon adenocarcinoma10.0BCL2L1, ABCC2

Graphical network of the top 20 diseases related to Dysembryoplastic Neuroepithelial Tumor:



Diseases related to dysembryoplastic neuroepithelial tumor

Clinical Features for Dysembryoplastic Neuroepithelial Tumor

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Drugs & Therapeutics for Dysembryoplastic Neuroepithelial Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Dysembryoplastic Neuroepithelial Tumor

Drug clinical trials:

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Search NIH Clinical Center for Dysembryoplastic Neuroepithelial Tumor

Search CenterWatch for Dysembryoplastic Neuroepithelial Tumor

Genetic Tests for Dysembryoplastic Neuroepithelial Tumor

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Anatomical Context for Dysembryoplastic Neuroepithelial Tumor

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32MalaCards
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MalaCards organs/tissues related to Dysembryoplastic Neuroepithelial Tumor:

32
Brain, Cerebellum, Temporal lobe, Caudate nucleus, Cortex, Parietal lobe

Animal Models for Dysembryoplastic Neuroepithelial Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dysembryoplastic Neuroepithelial Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.4BCL2L1, GFAP, OLIG2, MIB1, MAP2, GRIN1

Publications for Dysembryoplastic Neuroepithelial Tumor

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50PubMed
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Articles related to Dysembryoplastic Neuroepithelial Tumor:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
Electrocorticographic-histopathologic correlations implying epileptogenicity of dysembryoplastic neuroepithelial tumor. (24077279)
2013
2
Dysembryoplastic neuroepithelial tumor with rapid recurrence of pilocytic astrocytoma component. (23881357)
2013
3
Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation. (23432479)
2013
4
Mixed glioneuronal tumor: a dysembryoplastic neuroepithelial tumor with rosette-forming glioneuronal tumor component. (23163721)
2013
5
Glioblastoma Multiforme Arising From Dysembryoplastic Neuroepithelial Tumor in a Child in the Absence of Therapy. (24309599)
2013
6
Oligodendroglioma (WHO grade I) in a young epilepsy patient: a specific entity lying within the spectrum of dysembryoplastic neuroepithelial tumor? (23432071)
2013
7
Focal epilepsy associated with dysembryoplastic neuroepithelial tumor in the area of the caudate nucleus. (22809555)
2012
8
Dysembryoplastic neuroepithelial tumor originally diagnosed as astrocytoma and oligodendroglioma. (22990729)
2012
9
Intraventricular dysembryoplastic neuroepithelial tumor in a pediatric patient: is it the most common extracortical location for DNT? (20959995)
2011
10
Dysembryoplastic neuroepithelial tumor and probable sudden unexplained death in epilepsy: a case report. (21899755)
2011
11
A cortical dysembryoplastic neuroepithelial tumor initially occurring in the periventricular white matter. (21121739)
2010
12
Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature. (19267228)
2009
13
Dysembryoplastic neuroepithelial tumor: a clinicopathological study of 32 cases. (19165515)
2009
14
Surgery for epilepsy in children with dysembryoplastic neuroepithelial tumor: clinical spectrum, seizure outcome, neuroradiology, and pathology. (19066912)
2009
15
Familial occurrence of dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: case report. (18797318)
2008
16
The development of ring-shaped contrast enhancement in a case of cerebellar dysembryoplastic neuroepithelial tumor: case report. (18812941)
2008
17
MR and CT Evaluation of Dysembryoplastic Neuroepithelial Tumor. A Case Report. (24257009)
2008
18
Dysembryoplastic neuroepithelial tumor: a clinicopathologic and immunohistochemical study]. (17980099)
2007
19
Development of a pilocytic astrocytoma in a dysembryoplastic neuroepithelial tumor. Case report. (17566412)
2007
20
Gamma knife radiosurgery for epilepsy related to dysembryoplastic neuroepithelial tumor. (17063046)
2006
21
Endoscopic resection of an intraventricular dysembryoplastic neuroepithelial tumor of the septum pellucidum. (16465080)
2006
22
Development of contrast enhancement after long-term observation of a dysembryoplastic neuroepithelial tumor. (16314940)
2006
23
Rapidly growing dysembryoplastic neuroepithelial tumor: case report. (17277670)
2006
24
Long-term seizure outcome following surgery for dysembryoplastic neuroepithelial tumor. (16509148)
2006
25
Frequent association of cortical dysplasia in dysembryoplastic neuroepithelial tumor treated by epilepsy surgery. (16253690)
2005
26
Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor. (15921242)
2005
27
Resective surgery for epileptogenic dysembryoplastic neuroepithelial tumor in hemimegalencephaly. (16157925)
2005
28
Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy. (15581025)
2004
29
Familial occurrence of dysembryoplastic neuroepithelial tumor. (15037719)
2004
30
Dysembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. (12920757)
2003
31
Dysembryoplastic neuroepithelial tumor or dysembryoplastic cortical neurocytoma? (12777091)
2003
32
Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy. (12913847)
2003
33
Genetic differences between neurocytoma and dysembryoplastic neuroepithelial tumor and oligodendroglial tumors. (12507133)
2002
34
Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: a lesion often misdiagnosed as glioma: report of 10 cases. (11257624)
2001
35
Surgical strategy and outcomes for epileptic patients with focal cortical dysplasia or dysembryoplastic neuroepithelial tumor. (11902320)
2001
36
Bcl-2, bcl-x, and bax expression in dysembryoplastic neuroepithelial tumors. (10749285)
2000
37
Dysembryoplastic neuroepithelial tumor of the cerebellum and brainstem. Case report. (10969950)
2000
38
A case of an unclassified tumor closely resembling dysembryoplastic neuroepithelial tumor with rapid growth. (10982009)
2000
39
Melanotic differentiation in dysembryoplastic neuroepithelial tumor. (10774951)
2000
40
Dysembryoplastic neuroepithelial tumor: an immunohistochemical study with myelin oligodendrocyte glycoprotein. (10629143)
2000
41
Mixed dysembryoplastic neuroepithelial tumor and ganglioglioma. (9650758)
1998
42
Dysembryoplastic neuroepithelial tumor and oligodendroglioma: the diagnostic value of magnetic resonance spectroscopy. Case report and review of the literature. (17168506)
1998
43
Temporal lobe lesion demonstrating features of dysembryoplastic neuroepithelial tumor and ganglioglioma: a transitional form? (9101106)
1997
44
Neuroradiology case of the day. Dysembryoplastic neuroepithelial tumor. (9207553)
1997
45
A case of dysembryoplastic neuroepithelial tumor of the parietal lobe with characteristic magnetic resonance imaging. (8677797)
1996
46
How would you treat this patient? Dysembryoplastic neuroepithelial tumor. (8677483)
1996
47
Dysembryoplastic neuroepithelial tumor: a clinicopathologic and immunohistochemical study of 11 tumors including MIB1 immunoreactivity. (8998857)
1996
48
Dysembryoplastic neuroepithelial tumor: a curable cause of seizures. (10897819)
1996
49
Dysembryoplastic neuroepithelial tumor: morphological, immunocytochemical, and deoxyribonucleic acid analyses in a pediatric series. (7753346)
1995
50
Dysembryoplastic neuroepithelial tumor. (1543164)
1992

Genetic Variations for Dysembryoplastic Neuroepithelial Tumor

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Expression for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

Search GEO for disease gene expression data for Dysembryoplastic Neuroepithelial Tumor.

Pathways for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Sources:
49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1s 1004410.0SYP, CHGA, GFAP, S100B
2reticulin4410.0S100B, SYP, GFAP
3glutamate4410.0GFAP, ABCC2, GRIN1, IDH1
4l-amino acid449.9SYP, S100B, CHGA, MAP2
5streptozotocin449.9NES, SYP, GFAP, CHGA
6kainate44 2810.7GFAP, GRIN1, NES, SYP, MAP2
7ganglioside449.7NES, SYP, MAP2, GFAP
8dopamine44 28 11 2412.7CHGA, GFAP, GRIN1, MAP2, NES
9mk 57144 5910.6ABCG2, ABCC2, ABCC5
103-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.6S100B, ABCC2, BCL2L1, MAP2
11dbc-amp449.5MAP2, SYP, S100B, GFAP
12methanol44 2410.4MAP2, GFAP, MKI67, CHGA
13glutamine449.4GFAP, SYP, GRIN1, ABCG2, IDH1, S100B
14choline44 11 2411.3S100B, MAP2, SYP, PSIP1, NES, GFAP
15gaba449.3MAP2, S100B, SYP, CHGA, GRIN1, GFAP
16silver449.3MAP2, CHGA, SYP, MKI67, GFAP
17formaldehyde44 2410.3GFAP, MKI67, CHGA, SYP, S100B
18dutp449.2MKI67, SYP, BCL2L1, GFAP
19dexamethasone44 49 28 1112.1S100B, ABCC2, BCL2L1, ABCG2, GFAP
20hematoxylin449.1GFAP, MKI67, CHGA, MAP2, S100B, SYP
21platinum44 4910.1ABCC2, ABCC5, ABCG2, MVP
22rhodamine 12344 4910.1MVP, ABCG2, ABCC2
23ethanol44 49 11 2412.0MKI67, MAP2, GRIN1, SYP, S100B, GFAP
24probenecid44 28 59 49 1113.0ABCG2, MVP, ABCC2, ABCC5
25irinotecan44 49 1110.9MKI67, ABCC2, ABCG2, BCL2L1
26glycogen44 249.9MKI67, CHGA, SYP, S100B, MAP2, GFAP
27daunorubicin44 49 1110.9MVP, ABCG2, ABCC2, BCL2L1
28bromodeoxyuridine448.8S100B, GFAP, ABCG2, MKI67, CHGA, NES
29vinblastine44 49 1110.7ABCC2, MVP, MAP2, ABCG2, BCL2L1
30docetaxel44 49 59 1111.7MVP, BCL2L1, ABCC2, MAP2, ABCG2
31nitric oxide44 11 2410.7SYP, NES, S100B, CHGA, GRIN1, MAP2
32testosterone44 59 11 2411.6CHGA, S100B, MAP2, ABCG2, MKI67, GFAP
33adriamycin448.5MVP, ABCC5, ABCG2, BCL2L1, ABCC2
34mitomycin c448.5MKI67, ABCC2, MVP, ABCG2
35etoposide44 49 59 1111.4S100B, ABCG2, MVP, SYP, CHGA, BCL2L1
36vincristine44 49 1110.1MVP, MAP2, MKI67, ABCC2, BCL2L1, ABCG2
37oxygen44 249.1ABCC2, NES, CHGA, GRIN1, MKI67, BCL2L1
38epinephrine44 11 2410.0MVP, CHGA, MKI67, ABCC2, ABCG2
395fluorouracil447.9ABCG2, ABCC5, MKI67, MVP, BCL2L1, ABCC2
40doxorubicin44 49 119.8ABCC2, BCL2L1, MVP, MKI67, ABCC5, ABCG2
41lipid447.7GRIN1, ABCG2, S100B, MVP, NES, SYP
42retinoic acid44 248.6GFAP, ABCC2, MKI67, MAP2, GRIN1, CHGA
43progesterone44 59 28 11 2411.6S100B, NES, SYP, CHGA, MAP2, MKI67
44paraffin447.6BCL2L1, GFAP, MKI67, MAP2, CHGA, SYP
45atp44 288.6MVP, GFAP, BCL2L1, MAP2, CHGA, ABCG2
46vegf447.5BCL2L1, MAP2, CHGA, SYP, MKI67, MVP
47paclitaxel44 49 119.4BCL2L1, MKI67, S100B, MVP, CHGA, MAP2
48cisplatin44 49 59 1110.3SYP, MVP, CHGA, MKI67, ABCC2, ABCC5
49estrogen447.1NES, MVP, S100B, BCL2L1, SYP, CHGA
50tyrosine446.5MVP, PSIP1, NES, BCL2L1, GFAP, ABCG2

GO Terms for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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16Gene Ontology
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Cellular components related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:06007610.1GRIN1, SYP
2nuclear peripheryGO:0343999.5MAP2, PSIP1

Biological processes related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug transmembrane transportGO:0068559.7ABCG2, ABCC2
2response to oxidative stressGO:0069799.7ABCC2, PSIP1, IDH1

Molecular functions related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:0085149.8ABCC5, ABCC2
2ATPase activity, coupled to transmembrane movement of substancesGO:0426269.2ABCG2, ABCC5, ABCC2

Products for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Sources for Dysembryoplastic Neuroepithelial Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet