MCID: DYS006
MIFTS: 35

Dysembryoplastic Neuroepithelial Tumor malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Dysembryoplastic Neuroepithelial Tumor

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Aliases & Descriptions for Dysembryoplastic Neuroepithelial Tumor:

Name: Dysembryoplastic Neuroepithelial Tumor 11 48 54 13 68
Dysembryoplastic Neuroepithelial Neoplasm 11
 
Dnet 54

Characteristics:

Orphanet epidemiological data:

54
dysembryoplastic neuroepithelial tumor:
Inheritance: Not applicable; Age of onset: All ages

Classifications:



External Ids:

Disease Ontology11 DOID:2679
NCIt45 C9505
Orphanet54 ORPHA251946
UMLS via Orphanet69 C1266177

Summaries for Dysembryoplastic Neuroepithelial Tumor

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MalaCards based summary: Dysembryoplastic Neuroepithelial Tumor, also known as dysembryoplastic neuroepithelial neoplasm, is related to ganglioglioma and subependymal giant cell astrocytoma, and has symptoms including seizures An important gene associated with Dysembryoplastic Neuroepithelial Tumor is SYP (Synaptophysin), and among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Neuroscience. Affiliated tissues include temporal lobe, brain and cerebellum, and related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Dysembryoplastic Neuroepithelial Tumor

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Diseases related to Dysembryoplastic Neuroepithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioglioma30.8GFAP, IDH1
2subependymal giant cell astrocytoma30.3GFAP, S100B
3rosette-forming glioneuronal tumor of fourth ventricule11.1
4epilepsy10.5
52q33.1 microdeletion syndrome10.5MAP2, SYP
6anaplastic oligoastrocytoma10.5S100B, SYP
7fraxf syndrome10.5S100B, SYP
8hypogonadism cardiomyopathy10.4S100B, SYP
9inflammatory mfh10.4S100B, SYP
10space motion sickness10.4S100B, SYP
11oligodendroglioma10.4
12skin glomangioma10.4S100B, SYP
13l-cell glucagon-like peptide producing tumor10.4S100B, SYP
14grubben de cock borghgraef syndrome10.4GFAP, SYP
15bladder flat intraepithelial lesion10.4GFAP, SYP
16lice infestation10.4GFAP, SYP
17cauda equina neoplasm10.4GFAP, SYP
18glomus tumor10.4GFAP, SYP
19vulvar benign neoplasm10.3GFAP, SYP
20hypersensitivity reaction type ii disease10.3GFAP, SYP
21brainstem intraparenchymal clear cell meningioma10.3GFAP, SYP
22benign breast phyllodes tumor10.3IDH1, SYP
23atypical choroid plexus papilloma10.3GFAP, SYP
24lyme disease - neurological complications10.3GFAP, S100B
25pilomyxoid astrocytoma10.3GFAP, SYP
26cauda equina intradural extramedullary astrocytoma10.3GFAP, SYP
27choroid disease10.3GFAP, SYP
28chondroblastoma10.3GFAP, S100B
29subacute leukemia10.3GFAP, S100B
30vitamin metabolic disorder10.3GFAP, SYP
31pineoblastoma10.3GFAP, SYP
32plexopathy10.3GFAP, SYP
33pulmonary venoocclusive disease10.3GFAP, S100B
34astrocytoma10.3
35pseudoglandular variant testicular seminoma10.3GFAP, S100B
36malignant granular cell esophageal tumor10.3GFAP, SYP
37non-congenital cyst of kidney10.3S100B, SYP
38external ear disease10.3GFAP, S100B
39malignant pineal area germ cell neoplasm10.3GFAP, SYP
40diencephalic astrocytomas10.3GFAP, SYP
41pulmonary plasma cell granuloma10.3GFAP, SYP
42anus leiomyosarcoma10.3S100B, SYP
43hemiplegia alterans10.3GFAP, S100B
44epicardium cancer10.3GFAP, S100B
45amyotrophic lateral sclerosis type 1410.3MAP2, SYP
46megarbane jalkh syndrome10.3S100B, SYP
47peritoneal benign neoplasm10.3GFAP, SYP
48mesenchymoma10.2GFAP, SYP
49sm-ahnmd10.2NES, SYP
50papillary thymic adenocarcinoma10.2IDH1, SYP

Graphical network of the top 20 diseases related to Dysembryoplastic Neuroepithelial Tumor:



Diseases related to dysembryoplastic neuroepithelial tumor

Symptoms & Phenotypes for Dysembryoplastic Neuroepithelial Tumor

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UMLS symptoms related to Dysembryoplastic Neuroepithelial Tumor:


seizures

GenomeRNAi Phenotypes related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-359.0GRIN1, IDH1, NES

Drugs & Therapeutics for Dysembryoplastic Neuroepithelial Tumor

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Molecular-Guided Therapy for Childhood CancerRecruitingNCT02162732

Search NIH Clinical Center for Dysembryoplastic Neuroepithelial Tumor

Genetic Tests for Dysembryoplastic Neuroepithelial Tumor

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Anatomical Context for Dysembryoplastic Neuroepithelial Tumor

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MalaCards organs/tissues related to Dysembryoplastic Neuroepithelial Tumor:

36
Temporal lobe, Brain, Cerebellum, Caudate nucleus, Thalamus, Parietal lobe, Cortex

Publications for Dysembryoplastic Neuroepithelial Tumor

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Articles related to Dysembryoplastic Neuroepithelial Tumor:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Remitted epilepsy with dysembryoplastic neuroepithelial tumor involving the thalamus. (27163491)
2016
2
Malignant Transformation of a Dysembryoplastic Neuroepithelial Tumor (DNET) Characterized by Genome-Wide Methylation Analysis. (26921879)
2016
3
Dysembryoplastic Neuroepithelial Tumor of the Septum Pellucidum and the Supratentorial Midline: Histopathologic, Neuroradiologic, and Molecular Features of 7 Cases. (26796505)
2016
4
Atypical Teratoid Rhabdoid Tumor Diagnosis after Partial Resection of Dysembryoplastic Neuroepithelial Tumor: Case Report and Review of the Literature. (26978682)
2016
5
Radiologic response to radiation therapy concurrent with temozolomide for progressive simple dysembryoplastic neuroepithelial tumor. (27181792)
2016
6
Long-term drug-resistant temporal lobe epilepsy associated with a mixed ganglioglioma and dysembryoplastic neuroepithelial tumor in an elderly patient. (27127715)
2016
7
Dysembryoplastic neuroepithelial tumor: A rare brain tumor not to be misdiagnosed. (27057233)
2016
8
MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors. (26698155)
2016
9
A rare case of dysembryoplastic neuroepithelial tumor combined with encephalocraniocutaneous lipomatosis and intractable seizures. (28018467)
2016
10
Resection of a dysembryoplastic neuroepithelial tumor in the precentral gyrus. (26253415)
2015
11
BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas. (25346165)
2015
12
A peculiar histopathological form of dysembryoplastic neuroepithelial tumor with separated pilocytic astrocytoma and rosette-forming glioneuronal tumor components. (24735014)
2014
13
Manifestation and treatment of intraventricular dysembryoplastic neuroepithelial tumor. (24709201)
2014
14
Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge. (24448703)
2014
15
Dysembryoplastic neuroepithelial tumor transforming into malignancy: a case report. (25033864)
2014
16
Mixed glioneuronal tumor: a dysembryoplastic neuroepithelial tumor with rosette-forming glioneuronal tumor component. (23163721)
2013
17
Glioblastoma Multiforme Arising From Dysembryoplastic Neuroepithelial Tumor in a Child in the Absence of Therapy. (24309599)
2013
18
Oligodendroglioma (WHO grade I) in a young epilepsy patient: a specific entity lying within the spectrum of dysembryoplastic neuroepithelial tumor? (23432071)
2013
19
Dysembryoplastic neuroepithelial tumor, a pure glial tumor? Immunohistochemical and morphometric studies. (23530928)
2013
20
Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature. (24137435)
2013
21
Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. (23442159)
2013
22
Electrocorticographic-histopathologic correlations implying epileptogenicity of dysembryoplastic neuroepithelial tumor. (24077279)
2013
23
Dysembryoplastic Neuroepithelial Tumor: A Clinical, Neuroradiological, and Pathological Study of 15 Cases. (23752069)
2013
24
Dysembryoplastic neuroepithelial tumor with atypical presentation: MRI and diffusion tensor characteristics. (24421925)
2013
25
Dysembryoplastic neuroepithelial tumor with rapid recurrence of pilocytic astrocytoma component. (23881357)
2013
26
Dynamic changes in magnetic resonance imaging appearance of dysembryoplastic neuroepithelial tumor with or without malignant transformation. (23432479)
2013
27
Focal epilepsy associated with dysembryoplastic neuroepithelial tumor in the area of the caudate nucleus. (22809555)
2012
28
Dysembryoplastic neuroepithelial tumor originally diagnosed as astrocytoma and oligodendroglioma. (22990729)
2012
29
Dysembryoplastic neuroepithelial tumor-like neoplasm of the septum pellucidum: review of 2 cases with chromosome 1p/19q and IDH1 analysis. (22192702)
2012
30
Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. (22221701)
2012
31
A rare case of dysembryoplastic neuroepithelial tumor. (23230542)
2012
32
Diffuse ependymal dysembryoplastic neuroepithelial tumor causing spinal drop metastases: a case report. (22778572)
2012
33
Complex form variant of dysembryoplastic neuroepithelial tumor of the cerebellum. (22988535)
2012
34
Lhermitte-Duclos disease associated with dysembryoplastic neuroepithelial tumor differentiation with characteristic magnetic resonance appearance of "tiger striping". (21704939)
2011
35
A patient with a dysembryoplastic neuroepithelial tumor who underwent epilepsy surgery after initial seizure. (22777137)
2011
36
Dysembryoplastic neuroepithelial tumor and calcifying pseudoneoplasms of the neuraxis: a collision of two seizure-associated lesions. (21726506)
2011
37
Diffuse hemispheric dysembryoplastic neuroepithelial tumor: a new radiological variant associated with early-onset severe epilepsy. (21456916)
2011
38
Intraventricular dysembryoplastic neuroepithelial tumor in a pediatric patient: is it the most common extracortical location for DNT? (20959995)
2011
39
Dysembryoplastic neuroepithelial tumor and probable sudden unexplained death in epilepsy: a case report. (21899755)
2011
40
Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients. (20043747)
2010
41
Progressive biological behavior of a dysembryoplastic neuroepithelial tumor. (21196795)
2010
42
A cortical dysembryoplastic neuroepithelial tumor initially occurring in the periventricular white matter. (21121739)
2010
43
Sudden death due to dysembryoplastic neuroepithelial tumor. (21056878)
2010
44
F-18 FDG-PET imaging of dysembryoplastic neuroepithelial tumor-like astrocytoma. (19893407)
2009
45
Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature. (19267228)
2009
46
Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor. (19263357)
2009
47
Dysembryoplastic neuroepithelial tumor: a clinicopathological study of 32 cases. (19165515)
2009
48
Dysembryoplastic neuroepithelial tumor located in pericallosal and intraventricular area in a child. Case report. (19485727)
2009
49
Different pattern of expression of nestin in the non-specific form of dysembryoplastic neuroepithelial tumors compared to the simple and complex forms. (18998057)
2009
50
Surgery for epilepsy in children with dysembryoplastic neuroepithelial tumor: clinical spectrum, seizure outcome, neuroradiology, and pathology. (19066912)
2009

Variations for Dysembryoplastic Neuroepithelial Tumor

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Expression for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Search GEO for disease gene expression data for Dysembryoplastic Neuroepithelial Tumor.

Pathways for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Pathways related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
17.7GFAP, MAP2, NES, S100B, SYP
27.7GFAP, GRIN1, MAP2, S100B, SYP

GO Terms for genes affiliated with Dysembryoplastic Neuroepithelial Tumor

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Cellular components related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:006007610.2GRIN1, SYP
2intermediate filament cytoskeletonGO:004511110.1GFAP, NES
3terminal boutonGO:00431959.6GRIN1, SYP
4neuron projectionGO:00430059.2GRIN1, MAP2, SYP

Biological processes related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:00602919.9GFAP, S100B
2regulation of long-term neuronal synaptic plasticityGO:00481699.9GRIN1, SYP
3learning or memoryGO:00076119.9GRIN1, S100B
4memoryGO:00076139.8GRIN1, S100B
5regulation of neuronal synaptic plasticityGO:00481689.0GRIN1, S100B, SYP

Molecular functions related to Dysembryoplastic Neuroepithelial Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.5GRIN1, IDH1, S100B
2structural molecule activityGO:00051988.7GFAP, MAP2, NES

Sources for Dysembryoplastic Neuroepithelial Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet