MCID: DYS101
MIFTS: 33

Dysgerminoma malady

Summaries for Dysgerminoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the ovary. more...

MalaCards: Dysgerminoma is related to gonadoblastoma and gonadal dysgenesis. An important gene associated with Dysgerminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog). The compounds gold and forskolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Dysgerminoma

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10DISEASES, 44Novoseek, 60UMLS
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Aliases & Descriptions:

dysgerminoma 10 44 60


Related Diseases for Dysgerminoma

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17GeneCards, 18GeneDecks
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Diseases related to Dysgerminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma31.0TSPY10, TSPY3, TSPY1, SRY, KIT, WT1
2gonadal dysgenesis30.8WT1, SRY
3hypercalcemia30.5ALPP, PTHLH
4seminoma30.4CGA, CGB5, AFP, MAGEA4, INHA, KITLG
5ataxia telangiectasia30.3AFP, BRCA2, BRCA1
6hermaphroditism30.1SRY
7frasier syndrome30.1WT1, SRY
8turner syndrome30.1CGA, SRY, TSPY1
9choriocarcinoma30.1CGA, CGB5, AFP, INHA, ALPP
10endodermal sinus tumor30.0AFP
11male germ cell tumor, somatic30.0CGA, AFP
12amenorrhea29.7SRY
13thyroiditis29.7CGA
14pseudohermaphroditism29.7SRY, WT1
15astrocytoma29.7BRCA1, INHA
16androgen insensitivity syndrome29.7SRY, CGA
17sertoli cell tumor29.7ALPP, INHA, ENO2
18rhabdomyosarcoma29.7WT1, INHA, ENO2
19myeloid leukemia29.7KIT, KITLG, WT1
20pancreatitis29.7ALPP, KITLG, BRCA2
21cystadenoma29.7KRT7, INHA, BRCA1
22leydig cell tumor29.7CGB5, INHA, PTHLH, CGA
23sertoli-leydig cell tumor29.7WT1, AFP, INHA, KRT7
24down syndrome29.7CGA, CGB5, AFP, INHA, SRY
25leukemia29.7BRCA1, BRCA2, WT1, CTAG1B, KITLG, KIT
26lung small cell carcinoma29.7CTAG1B, MAGEA4, INHA, KITLG, KIT, KRT7
27sarcoma29.7BRCA2, WT1, ENO2, KIT, KITLG, MAGEA4
28adenocarcinoma29.7BRCA1, BRCA2, WT1, CTAG1B, CGB5, AFP
29dysgerminoma of ovary10.8
30ovarian gonadoblastoma10.3
31pediatric ovarian dysgerminoma10.2
32neuronitis10.1
33pineal dysgerminoma10.1
3446 xy gonadal dysgenesis10.1
35testicular gonadoblastoma10.0
36choriocarcinoma of ovary10.0
37encephalitis10.0
38ovarian disease10.0
39germ cell tumors10.0KIT
40epithelioid trophoblastic tumor10.0INHA
41renal oncocytoma10.0KRT7
42leiomyoma10.0KIT
43endometriosis10.0CGA
44von hippel-lindau disease10.0INHA
45merkel cell carcinoma10.0ENO2
46adenomatoid tumor10.0WT1
47nephroblastoma10.0WT1
48ependymoma10.0ENO2
49cerebral primitive neuroectodermal tumor10.0ENO2
50paraneoplastic syndromes10.0PTHLH

Graphical network of the top 20 diseases related to Dysgerminoma:



Diseases related to dysgerminoma

Clinical Features for Dysgerminoma

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Drugs & Therapeutics for Dysgerminoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Dysgerminoma

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Anatomical Context for Dysgerminoma

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32MalaCards
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MalaCards organs/tissues related to Dysgerminoma:

32
Ovary

Animal Models for Dysgerminoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Dysgerminoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.6BRCA2, AFP, INHA, KITLG, KIT, BRCA1
2MP:00053899.3SRY, BRCA1, BRCA2, WT1, CGA, AFP
3MP:00053799.1BRCA1, BRCA2, WT1, AFP, INHA, KITLG

Publications for Dysgerminoma

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Genetic Variations for Dysgerminoma

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Expression for genes affiliated with Dysgerminoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysgerminoma

Search GEO for disease gene expression data for Dysgerminoma.

Pathways for genes affiliated with Dysgerminoma

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Compounds for genes affiliated with Dysgerminoma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Dysgerminoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1gold4410.5BRCA2, AFP
2forskolin44 49 1112.4WT1, ENO2
3oestriol4410.4CGA, AFP, CGB5
4h2o24410.3AFP, CGA, ALPP
5paclitaxel44 49 1112.3CGB5, BRCA2, AFP, BRCA1
6ag-12964410.2KIT, KITLG, PTHLH
7prostaglandin4410.2CGA, KITLG, CGB5
8b 7234410.2AFP, WT1, ALPP, KRT7
9cycloheximide4410.2BRCA2, ALPP, CGB5, BRCA1
10diethylstilbestrol44 28 1112.2CGA, ENO2, CGB5, AFP
11toluidine4410.1KITLG, KIT, ENO2
12agarose4410.1BRCA1, INHA, KITLG, KIT, SRY
13carboplatin44 49 1112.1ENO2, KITLG, CGA, BRCA1, AFP
14hematoxylin4410.1ENO2, KRT7, INHA, KIT
15clomiphene citrate4410.0AFP, CGB5, CGA
16ibmx44 28 5912.0CGB5, ENO2, ALPP, PTHLH, CGA
17bleomycin44 1111.0CGB5, BRCA1, BRCA2, CGA, PTHLH, AFP
18cyclophosphamide44 49 1112.0CGB5, PTHLH, KITLG, AFP, BRCA1, CGA
19hydroxyurea44 49 1112.0ALPP, KIT, KITLG, CGB5, BRCA2, BRCA1
20folate449.9ALPP, CGA, CGB5, AFP, BRCA2, BRCA1
21vincristine44 49 1111.9KIT, BRCA1, BRCA2, WT1, AFP, PTHLH
22dmso449.9CGA, CGB5, AFP, ENO2, ALPP, KITLG
23tamoxifen44 49 28 1112.9CGB5, CGA, BRCA2, ALPP, BRCA1, PTHLH
24actinomycin d449.9KIT, CGA, CGB5, AFP, KITLG, PTHLH
25doxorubicin44 49 1111.9KIT, KITLG, CGA, AFP, WT1, BRCA1
26norepinephrine44 11 2411.8CGA, CGB5, KITLG, PTHLH, ENO2, ALPP
27glycogen44 2410.8AFP, KRT7, PTHLH, ENO2, CGB5, KIT
28etoposide44 49 59 1112.8WT1, CGA, CGB5, AFP, ENO2, BRCA2
295-aza-2deoxycytidine449.8TSPY1, KRT7, KITLG, CTAG1B, BRCA1
30heparin44 28 11 2412.8ALPP, ENO2, PTHLH, KITLG, AFP, CGA
31ribonucleic acid449.8INHA, WT1, CGA, CGB5, KITLG, ENO2
32dbc-amp449.8PTHLH, ENO2, CGA, CGB5
33lactate449.7ENO2, CGB5, KITLG, ALPP, PTHLH, KIT
34creatinine449.7AFP, ENO2, ALPP, PTHLH, WT1, CGA
35oligonucleotide449.6KIT, WT1, BRCA1, BRCA2, AFP, INHA
36steroid449.6CGB5, PTHLH, BRCA1, BRCA2, WT1, CGA
37estradiol44 11 2411.6BRCA1, BRCA2, CGA, SRY, CGB5, AFP
38glutamine449.6ENO2, WT1, BRCA2, KIT, BRCA1, AFP
39thymidine44 2410.6KITLG, ENO2, PTHLH, KIT, AFP, WT1
40alanine449.6PTHLH, ENO2, CGA, SRY, AFP, ALPP
41progestin449.6CGA, ALPP, CGB5, PTHLH
42methotrexate44 49 1111.5BRCA1, CGA, ENO2, BRCA2, CGB5, AFP
43cisplatin44 49 59 1112.5ALPP, BRCA1, BRCA2, CGB5, ENO2, KITLG
44serine449.4SRY, CGB5, CGA, PTHLH, AFP, ALPP
45progesterone44 59 28 11 2413.3WT1, PTHLH, CGA, ENO2, KRT7, KIT
46vegf449.3AFP, KITLG, KRT7, CGB5, CGA, PTHLH
47tyrosine449.3INHA, SRY, BRCA1, WT1, AFP, KITLG
48retinoic acid44 2410.2KIT, ALPP, ENO2, BRCA1, BRCA2, PTHLH
49paraffin449.0CGB5, CGA, WT1, BRCA2, BRCA1, AFP
50testosterone44 59 11 2411.9KRT7, KIT, KITLG, INHA, WT1, CGA

GO Terms for genes affiliated with Dysgerminoma

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16Gene Ontology
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Cellular components related to Dysgerminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.8TSPY10, WT1, AFP, KITLG, KIT, KRT7

Biological processes related to Dysgerminoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1germ cell programmed cell deathGO:03523410.4KITLG, KIT
2positive regulation of male gonad developmentGO:200002010.3SRY, WT1
3regulation of cell proliferationGO:04212710.1KIT, INHA, BRCA1
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.1BRCA1, BRCA2
5gonadal mesoderm developmentGO:00750610.1TSPY1, TSPY3, TSPY10
6hemopoiesisGO:03009710.1BRCA2, KITLG, KIT
7male gonad developmentGO:00858410.1INHA, WT1, KITLG, KIT, SRY
8spermatogenesisGO:0072839.8KIT, BRCA2, TSPY1, TSPY3, TSPY10
9cell differentiationGO:0301549.7INHA, SRY, TSPY1, TSPY3, TSPY10
10nucleosome assemblyGO:0063349.6TSPY3, TSPY1, TSPY10

Molecular functions related to Dysgerminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.1PTHLH, INHA, CGA

Products for genes affiliated with Dysgerminoma

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  • Antibodies
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Sources for Dysgerminoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet