MCID: DYS101
MIFTS: 44

Dysgerminoma malady

Summaries for Dysgerminoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the ovary. more...

MalaCards: Dysgerminoma is related to gonadoblastoma and hypercalcemia. An important gene associated with Dysgerminoma is KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog). The compounds gold and forskolin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and small intestine, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Dysgerminoma

Sources:
10DISEASES, 45Novoseek, 61UMLS
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Aliases & Descriptions:

dysgerminoma 10 45 61


Related Diseases for Dysgerminoma

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17GeneCards, 18GeneDecks
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Diseases related to Dysgerminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma31.0TSPY10, TSPY3, TSPY1, SRY, KIT, WT1
2hypercalcemia30.6ALPP, PTHLH
3swyer syndrome30.5SRY
4turner syndrome30.4CGA, SRY, TSPY1
5ataxia telangiectasia30.3AFP, BRCA2, BRCA1
6teratoma30.3CGA, CGB5, AFP, KIT, KRT7, ENO2
7frasier syndrome30.2WT1, SRY
8germ cell tumors30.0KIT
9male germ cell tumor, somatic30.0CGA, AFP
10germinoma30.0CGA, CGB5, AFP, INHA, KIT, ALPP
11amenorrhea29.8SRY
12astrocytoma29.8BRCA1, INHA
13androgen insensitivity syndrome29.8SRY, CGA
14sertoli cell tumor29.8ALPP, INHA, ENO2
15germ cell cancer29.8CGA, AFP, ALPP
16cystadenoma29.8KRT7, INHA, BRCA1
17sertoli-leydig cell tumor29.8WT1, AFP, INHA, KRT7
18wilms tumor29.8BRCA2, WT1, INHA, KRT7, SRY, ENO2
19adenocarcinoma29.8BRCA1, BRCA2, WT1, CTAG1B, CGB5, AFP
20ovarian gonadoblastoma10.4
21pediatric ovarian dysgerminoma10.2
22ataxia10.2
23pineal dysgerminoma10.1
24precocious puberty10.1
25testicular gonadoblastoma10.0
26ovarian germ cell tumor10.0
27mixed germ cell tumor10.0
28epithelioid trophoblastic tumor10.0INHA
29renal oncocytoma10.0KRT7
30leiomyoma10.0KIT
31thyroiditis10.0CGA
32endometriosis10.0CGA
33hermaphroditism10.0SRY
34von hippel-lindau disease10.0INHA
35merkel cell carcinoma10.0ENO2
36endodermal sinus tumor10.0AFP
37adenomatoid tumor10.0WT1
38nephroblastoma10.0WT1
39ependymoma10.0ENO2
40cerebral primitive neuroectodermal tumor10.0ENO2
41paraneoplastic syndromes10.0PTHLH
42bladder carcinoma10.0CGB5
43meningioma10.0INHA
44testicular disease10.0SRY
45angiomyolipoma10.0KIT
46adult t-cell leukemia10.0PTHLH
47gonadal dysgenesis10.0WT1, SRY
48pseudohermaphroditism10.0SRY, WT1
49luteoma10.0SRY, CGA
50rhabdoid tumor10.0ALPP, WT1

Graphical network of the top 20 diseases related to Dysgerminoma:



Diseases related to dysgerminoma

Clinical Features for Dysgerminoma

Drugs & Therapeutics for Dysgerminoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Dysgerminoma

Drug clinical trials:

Search ClinicalTrials for Dysgerminoma

Search NIH Clinical Center for Dysgerminoma

Search CenterWatch for Dysgerminoma

Genetic Tests for Dysgerminoma

Anatomical Context for Dysgerminoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Dysgerminoma:

33
Lymph node, Brain, Small intestine, Lung, Pancreas, Thyroid, Breast, Skin, Ovary, Uterus, Placenta, Cervix, Myeloid, T cells

Animal Models for Dysgerminoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Dysgerminoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.6BRCA2, AFP, INHA, KITLG, KIT, BRCA1
2MP:00053899.3SRY, BRCA1, BRCA2, WT1, CGA, AFP
3MP:00053799.1BRCA1, BRCA2, WT1, AFP, INHA, KITLG

Publications for Dysgerminoma

Sources:
51PubMed
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Articles related to Dysgerminoma:

(show top 50)    (show all 396)
idTitleAuthorsYear
1
Ovarian dysgerminoma: a case report and literature review. (23929062)
2013
2
Gonadoblastoma: Case report of two young patients with isochromosome 12p found in the dysgerminoma overgrowth component in one case. (22906432)
2012
3
Ovarian gonadoblastoma with dysgerminoma in a woman with 46XX karyotype. (21355962)
2011
4
Coexistence of gonadoblastoma and dysgerminoma in a dysgenetic gonad on touch preparation: a case report. (21162092)
2011
5
Swyer syndrome, 46,XY gonadal dysgenesis, a sex reversal disorder with dysgerminoma: a case report and literature review. (22268289)
2011
6
Diagnosis of ovarian dysgerminoma during pregnancy. (21152820)
2010
7
The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. (19642973)
2009
8
A case of dysgerminoma of the ovary with early carcinomatous features. (17593215)
2007
9
Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis. (16554737)
2006
10
An ovarian dysgerminoma in Down syndrome. Hypothesis about the association. (16515627)
2006
11
Ovarian dysgerminoma associated with Pseudo-Meigs' syndrome and functioning ovarian stroma: a case report. (15863182)
2005
12
Gonadoblastoma: evidence for a stepwise progression to dysgerminoma in a dysgenetic ovary. (15968543)
2005
13
Idiopathic thrombocytopenia associated with dysgerminoma in a patient with androgen insensitivity syndrome. (16051340)
2005
14
Intracranial metastases from an ovarian dysgerminoma in a 2-year-old dog. (11716030)
2001
15
Primary ovarian dysgerminoma in a patient with a germline BRCA1 mutation. (11109172)
2000
16
Unicornuate uterus with a rudimentary horn and ovarian dysgerminoma. A case report. (10649813)
1999
17
Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review. (9702861)
1998
18
Successful pregnancy after treatment of stage III bilateral ovarian dysgerminoma. (8652470)
1995
19
Dysgerminoma and gonadal dysgenesis in a 46,XX female with no evidence of Y chromosomal DNA. (7774849)
1995
20
Effect of estrogen and progesterone on the growth of human ovarian dysgerminoma heterotransplanted to athymic nude mice. (1867584)
1991
21
Fine-needle aspiration biopsy of seminoma and dysgerminoma: cytologic, histologic, and electron microscopic correlations. (2159868)
1990
22
Dysgerminoma. The Radiumhemmet series 1927-1984. (2293868)
1990
23
Dysgerminoma of the ovary with rhabdomyosarcoma. Report of a case. (2680053)
1989
24
Advanced ovarian dysgerminoma with cure of tumor persistent in meninges. (2722068)
1989
25
Primary extraovarian dysgerminoma. (3343802)
1988
26
Pure dysgerminoma of the ovary with elevated serum human chorionic gonadotropin: diagnostic and therapeutic considerations. (2579008)
1985
27
Analysis of serum lactic dehydrogenase levels and its isoenzymes in ovarian dysgerminoma. (4018662)
1985
28
Dysgerminoma with syncytiotrophoblastic giant cells presenting as a hydatidiform mole. (6745734)
1984
29
Ataxia-telangiectasia with dysgerminoma of right ovary, papillary carcinoma of thyroid, and adenocarcinoma of pancreas. (6467138)
1984
30
Association of dysgerminoma and gaucher's disease. (6821841)
1983
31
Ovarian germinoma (dysgerminoma) with elevated serum lactic dehydrogenase: case report and review of literature. (7059933)
1982
32
Bilateral gonadoblastoma/dysgerminoma in a 46 XY individual: case report with hormonal studies. (7076870)
1982
33
Gonadoblastoma and dysgerminoma in a true hermaphrodite with a 46,XX karyotype. (7246672)
1981
34
Dysgerminoma with syncytiotrophoblastic giant cells. A histologically and clinically distinctive subtype of dysgerminoma. (7270783)
1981
35
Transformation of endodermal sinus tumor to dysgerminoma following chemotherapy. (7223804)
1981
36
Cytogenetic studies in gonadal dysgenesis with dysgerminoma. (984113)
1976
37
Essential hypernatremia, absence of thirst, hypopituitarism, and hypothalamic destruction due to a dysgerminoma. (4679411)
1972
38
Dysgerminoma: presentations and review. (5293535)
1970
39
Dysgerminoma of the ovary. (5732757)
1968
40
Clinical malignancy of endocrine tumors of the ovary and dysgerminoma. (4289598)
1967
41
Ultrastructural and biochemical studies of estrogen secretory capacity of a "nonfunctional" ovarian neoplasm (dysgerminoma). (6050762)
1967
42
Dysgerminoma in a 20-year-old female german shepherd dog. (6067990)
1967
43
Ovarian dysgerminoma. (6026459)
1967
44
Dysgerminoma of the ovary in a patient with Turner's syndrome. (13887114)
1962
45
Dysgerminoma complicating pregnancy. (14454547)
1962
46
Structure, origin and histological relations of dysgerminoma. (14403885)
1959
47
Dysgerminoma ovarii. (13069746)
1953
48
Dysgerminoma of the ovary. (13081535)
1953
49
Two cases of dysgerminoma ovarii, one occurring in a malignant teratoma in association with acute myelocytic leukaemia. (15428932)
1950
50
Dysgerminoma of the ovary. (21000891)
1946

Genetic Variations for Dysgerminoma

Expression for genes affiliated with Dysgerminoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysgerminoma

Search GEO for disease gene expression data for Dysgerminoma.

Pathways for genes affiliated with Dysgerminoma

Compounds for genes affiliated with Dysgerminoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
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Compounds related to Dysgerminoma according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1gold4510.5BRCA2, AFP
2forskolin45 50 1112.4ENO2, WT1
3oestriol4510.4AFP, CGB5, CGA
4h2o24510.3ALPP, AFP, CGA
5paclitaxel45 50 1112.3BRCA1, BRCA2, CGB5, AFP
6ag-12964510.2PTHLH, KIT, KITLG
7prostaglandin4510.2KITLG, CGB5, CGA
8b 7234510.2WT1, AFP, KRT7, ALPP
9cycloheximide4510.2BRCA1, BRCA2, CGB5, ALPP
10diethylstilbestrol45 29 1112.2CGA, CGB5, AFP, ENO2
11toluidine4510.1ENO2, KIT, KITLG
12agarose4510.1BRCA1, INHA, KITLG, KIT, SRY
13carboplatin45 50 1112.1BRCA1, CGA, AFP, KITLG, ENO2
14hematoxylin4510.1INHA, KIT, KRT7, ENO2
15clomiphene citrate4510.0AFP, CGB5, CGA
16ibmx45 29 6012.0ALPP, ENO2, PTHLH, CGB5, CGA
17bleomycin45 1111.0BRCA1, BRCA2, CGA, CGB5, AFP, PTHLH
18cyclophosphamide45 50 1112.0BRCA1, CGA, CGB5, AFP, KITLG, PTHLH
19hydroxyurea45 50 1112.0BRCA1, BRCA2, CGB5, KITLG, KIT, ALPP
20folate459.9BRCA1, BRCA2, CGA, CGB5, AFP, ALPP
21vincristine45 50 1111.9BRCA1, BRCA2, WT1, CGB5, AFP, KIT
22dmso459.9CGA, CGB5, AFP, KITLG, ENO2, ALPP
23tamoxifen45 50 29 1112.9BRCA1, BRCA2, CGA, CGB5, PTHLH, ALPP
24actinomycin d459.9CGA, CGB5, AFP, KITLG, KIT, PTHLH
25doxorubicin45 50 1111.9BRCA1, WT1, CGA, CGB5, AFP, KITLG
26norepinephrine45 11 2411.8CGA, CGB5, KITLG, PTHLH, ENO2, ALPP
27glycogen45 2410.8CGB5, AFP, KIT, KRT7, PTHLH, ENO2
28etoposide45 50 60 1112.8BRCA1, BRCA2, WT1, CGA, CGB5, AFP
295-aza-2deoxycytidine459.8BRCA1, CTAG1B, KITLG, KRT7, TSPY1
30heparin45 29 11 2412.8BRCA1, CGA, AFP, KITLG, PTHLH, ENO2
31ribonucleic acid459.8WT1, CGA, CGB5, INHA, KITLG, KIT
32dbc-amp459.8ENO2, PTHLH, CGB5, CGA
33lactate459.7CGA, CGB5, AFP, KITLG, KIT, PTHLH
34creatinine459.7WT1, CGA, CGB5, AFP, KITLG, PTHLH
35oligonucleotide459.6BRCA1, BRCA2, WT1, AFP, INHA, KIT
36steroid459.6BRCA1, BRCA2, WT1, CGA, CGB5, AFP
37estradiol45 11 2411.6BRCA1, BRCA2, CGA, CGB5, AFP, INHA
38glutamine459.6BRCA1, BRCA2, WT1, AFP, KIT, ENO2
39thymidine45 2410.6BRCA1, BRCA2, WT1, AFP, KITLG, KIT
40alanine459.6BRCA1, CGA, AFP, INHA, KITLG, SRY
41progestin459.6CGA, CGB5, PTHLH, ALPP
42methotrexate45 50 1111.5BRCA1, BRCA2, CGA, CGB5, AFP, KITLG
43cisplatin45 50 60 1112.5BRCA1, BRCA2, CGA, CGB5, AFP, KITLG
44serine459.4BRCA1, WT1, CGA, CGB5, AFP, KITLG
45progesterone45 60 29 11 2413.3BRCA1, BRCA2, WT1, CGA, CGB5, AFP
46vegf459.3BRCA1, WT1, CGA, CGB5, AFP, KITLG
47tyrosine459.3BRCA1, WT1, CGB5, AFP, INHA, KITLG
48retinoic acid45 2410.2BRCA1, BRCA2, WT1, CGB5, AFP, KITLG
49paraffin459.0BRCA1, ENO2, PTHLH, KRT7, KIT, KITLG
50testosterone45 60 11 2411.9BRCA1, BRCA2, ALPP, ENO2, PTHLH, SRY

GO Terms for genes affiliated with Dysgerminoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Dysgerminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.8TSPY10, WT1, AFP, KITLG, KIT, KRT7

Biological processes related to Dysgerminoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1germ cell programmed cell deathGO:03523410.4KIT, KITLG
2positive regulation of male gonad developmentGO:200002010.3SRY, WT1
3regulation of cell proliferationGO:04212710.1KIT, INHA, BRCA1
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.1BRCA1, BRCA2
5gonadal mesoderm developmentGO:00750610.1TSPY1, TSPY3, TSPY10
6hemopoiesisGO:03009710.1KIT, KITLG, BRCA2
7male gonad developmentGO:00858410.1SRY, KIT, KITLG, INHA, WT1
8spermatogenesisGO:0072839.8BRCA2, KIT, TSPY1, TSPY3, TSPY10
9cell differentiationGO:0301549.7INHA, SRY, TSPY1, TSPY3, TSPY10
10nucleosome assemblyGO:0063349.6TSPY10, TSPY3, TSPY1

Molecular functions related to Dysgerminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.1PTHLH, INHA, CGA

Products for genes affiliated with Dysgerminoma

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Sources for Dysgerminoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet