MCID: DYS101
MIFTS: 43

Dysgerminoma malady

Summaries for Dysgerminoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the ovary. more...

MalaCards: Dysgerminoma is related to gonadoblastoma and seminoma. An important gene associated with Dysgerminoma is PTHLH (parathyroid hormone-like hormone), and among its related pathways are G alpha (s) signalling events and Peptide hormone metabolism. The compounds ag-1296 and clodronate have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and lymph node, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Dysgerminoma

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11DISEASES, 46Novoseek, 63UMLS
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Aliases & Descriptions:

dysgerminoma 11 46 63


Related Diseases for Dysgerminoma

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18GeneCards, 19GeneDecks
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Diseases related to Dysgerminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma31.1KIT, SRY
2seminoma30.4CGA, KIT, AFP, INHA
3hermaphroditism30.3SRY
4teratoma30.3AFP, KIT, CGA
5turner syndrome30.3SRY, CGA
6choriocarcinoma30.1CGA, AFP, INHA
7endodermal sinus tumor30.1INHA, AFP
8germinoma29.9CGA, KIT, AFP, INHA
9androgen insensitivity syndrome29.9SRY, CGA
10sertoli-leydig cell tumor29.9INHA, AFP
11leydig cell tumor29.8INHA, PTHLH, CGA
12wilms tumor29.8SRY, INHA
13adenocarcinoma29.7INHA, AFP, PTHLH
14down syndrome29.7INHA, AFP, SRY, CGA
15gonadal dysgenesis10.6
16hypercalcemia10.4
17swyer syndrome10.3
18ovarian gonadoblastoma10.3
19dysgerminoma of ovary10.3
20pediatric ovarian dysgerminoma10.2
21ataxia telangiectasia10.2
22ataxia10.2
23germ cell tumors10.2
24neuronitis10.1
25pineal dysgerminoma10.1
26frasier syndrome10.1
27testicular disease10.1SRY
28epithelioid trophoblastic tumor10.1INHA
29sertoli cell tumor10.1INHA
30oligohydramnios10.1AFP
31encephalitis10.0
32precocious puberty10.0
33mixed germ cell tumor10.0
34hyperprolactinemia10.0PTHLH, CGA
35luteoma10.0CGA, SRY
36endometrial stromal sarcoma10.0INHA, KIT
37placental site trophoblastic tumor10.0INHA, CGA
38prolactinoma10.0CGA, PTHLH
39trophoblastic neoplasm10.0CGA, INHA
40hypospadias10.0CGA, SRY
41cryptorchidism10.0CGA, SRY
42aorta atresia10.0INHA, CGA
43islet cell tumor10.0AFP, PTHLH
44male infertility10.0CGA, SRY
45abrikosov's tumor10.0CGA, INHA
46gestational trophoblastic neoplasm10.0INHA, CGA
47leiomyosarcoma10.0KIT, INHA
48hematologic cancer10.0PTHLH, KIT
49klinefelter's syndrome10.0INHA, CGA
50azoospermia10.0SRY, CGA

Graphical network of the top 20 diseases related to Dysgerminoma:



Diseases related to dysgerminoma

Symptoms for Dysgerminoma

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Drugs & Therapeutics for Dysgerminoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Dysgerminoma

Drug clinical trials:

Search ClinicalTrials for Dysgerminoma

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Genetic Tests for Dysgerminoma

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Anatomical Context for Dysgerminoma

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34MalaCards
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MalaCards organs/tissues related to Dysgerminoma:

34
Ovary, Lung, Lymph node, Breast, Skin, Pancreas, T cells, Myeloid, Placenta, Thyroid, Testes, Uterus, Brain, Cervix

Animal Models for Dysgerminoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Dysgerminoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6KIT, AFP, INHA
2MP:00053767.5INHA, AFP, PTHLH, KIT, CGA
3MP:00107687.3INHA, AFP, PTHLH, SRY, KIT
4MP:00053797.2CGA, KIT, SRY, PTHLH, AFP, INHA
5MP:00053897.1INHA, AFP, PTHLH, SRY, KIT, CGA

Publications for Dysgerminoma

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53PubMed
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Articles related to Dysgerminoma:

(show top 50)    (show all 392)
idTitleAuthorsYear
1
Microscopic dysgerminoma associated with anti-Ma2 paraneoplastic encephalitis in a patient with gonadal dysgenesis. (23518911)
2013
2
Ovarian dysgerminoma in an adolescent: a case report. (24377208)
2013
3
Novel mutation of the sex-determining region on the Y chromosome in a 46,XY female patient with monolateral dysgerminoma: a case report. (22889418)
2013
4
Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report. (24179931)
2013
5
Bilateral dysgerminoma in a patient with a previous diagnosis of Swyer syndrome. (22176344)
2012
6
Ovarian dysgerminoma in two sisters. (23012179)
2008
7
46 XY pure gonadal dysgenesis with gonadoblastoma and dysgerminoma. (19472738)
2008
8
Medical image. A prepubescent mass. Swyer syndrome with a bilateral dysgerminoma. (18392069)
2008
9
Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis. (16554737)
2006
10
Gonadoblastoma with contralateral dysgerminoma in a young female--a case report. (16933739)
2006
11
Familial ovarian dysgerminomas (Swyer syndrome) in females associated with 46 XY-karyotype. (12012620)
2002
12
Dysgerminoma associated with hypercalcemia: A case report. (11431795)
2001
13
Pregnancy in a woman with a Y chromosome after removal of an ovarian dysgerminoma. (11104633)
2000
14
Advanced stage of dysgerminoma in testicular feminisation: is radical surgery necessary? (10925918)
2000
15
An unusual case of urinary incontinence, ataxia-telangiectasia, and metastatic dysgerminoma: case report and review of the literature. (9301718)
1997
16
Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46XX karyotype. (7789879)
1995
17
Accumulation of gamma/delta T cells in human dysgerminoma and seminoma: roles in autologous tumor killing and granuloma formation. (7622197)
1995
18
Ovarian dysgerminoma: color Doppler ultrasonographic findings and comparison with CT and MR imaging findings. (8551550)
1995
19
The association of ovarian dysgerminoma and gonadoblastoma in a phenotypic female with 46 XY karyotype. (8005142)
1994
20
Gonadoblastoma and dysgerminoma associated with 46,XY pure gonadal dysgenesis--a case report. (8305146)
1993
21
Dysgerminoma of the ovary. An immunohistochemical study of tumor-infiltrating lymphoreticular cells and tumor cells. (8453580)
1993
22
Characterization of the inflammatory infiltrate in ovarian dysgerminoma: an immunocytochemical study. (1607150)
1992
23
Fine-needle aspiration biopsy of seminoma and dysgerminoma: cytologic, histologic, and electron microscopic correlations. (2159868)
1990
24
Dysgerminoma: a study of 13 cases from the Connecticut Tumor Registry. (2743762)
1989
25
Neuron-specific enolase as a serum marker for immature teratoma and dysgerminoma. (2910781)
1989
26
Experimental endocrinotherapy with tamoxifen of human ovarian dysgerminoma transplanted into nude mice. (3429992)
1987
27
Human chorionic gonadotrophin producing ovarian dysgerminoma. (3665890)
1987
28
Urinary retention secondary to ovarian dysgerminoma in a girl. (4012986)
1985
29
Pure dysgerminoma of the ovary with elevated serum human chorionic gonadotropin: diagnostic and therapeutic considerations. (2579008)
1985
30
Conservative treatment of ovarian dysgerminoma with subsequent pregnancy. (6704293)
1984
31
Dysgerminoma with syncytiotrophoblastic giant cells presenting as a hydatidiform mole. (6745734)
1984
32
Association of dermatomyositis and dysgerminoma in a 16-year-old patient. (6838683)
1983
33
Gonadoblastoma and dysgerminoma with ataxia-telangiectasia. (990441)
1976
34
Bilateral gonadoblastoma with dysgerminoma. A case report. (5057796)
1972
35
Essential hypernatremia, absence of thirst, hypopituitarism, and hypothalamic destruction due to a dysgerminoma. (4679411)
1972
36
Bilateral metachronous dysgerminoma with a 15-year interval. (5574081)
1971
37
Hormone studies of an ovarian dysgerminoma. (5129555)
1971
38
Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. (5094323)
1971
39
Ovarian dysgerminoma. A survey and 12 cases. (5658174)
1968
40
Late results of treatment of ovarian dysgerminoma in the material of the Institute of Oncology in the years 1947-1959. (6006207)
1966
41
Dysgerminoma in pregnancy. Report of a case. (5925036)
1966
42
DYSGERMINOMA OF THE OVARY: A CLINICAL REPORT OF 20 CASES. (14248209)
1964
43
A case of retroperitoneal metastasis of dysgerminoma ovarii. (14010609)
1962
44
Dysgerminoma ovarii. (13069746)
1953
45
Dysgerminoma treated with nitrogen mustard. (14894566)
1952
46
Ovarian dysgerminoma. (18864048)
1948
47
Fertility and dysgerminoma ovarii. (18877067)
1948
48
Dysgerminoma ovarii. (20247858)
1947
49
Dysgerminoma of the ovary. (20288041)
1947
50
A Case of Ovarian Dysgerminoma. (19992879)
1944

Variations for Dysgerminoma

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Expression for genes affiliated with Dysgerminoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dysgerminoma

Search GEO for disease gene expression data for Dysgerminoma.

Pathways for genes affiliated with Dysgerminoma

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51PathCards, 56Reactome, 39NCBI BioSystems Database
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Pathways related to Dysgerminoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CGA, PTHLH
2
Show member pathways
9.3CGA, INHA
39.1CGA, AFP

Compounds for genes affiliated with Dysgerminoma

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46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Dysgerminoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1ag-12964610.0KIT, PTHLH
2clodronate46 52 1211.9CGA, PTHLH
3cloprostenol46 3010.7CGA, INHA
43beta-hydroxysteroid469.6CGA, INHA
5oestriol469.6CGA, AFP
6dbc-amp469.5CGA, PTHLH
7hematoxylin469.5KIT, INHA
8clomiphene citrate469.5AFP, CGA
9ifosfamide46 1210.5CGA, AFP
10ccl446 3010.4AFP, PTHLH
11diethylstilbestrol46 30 1211.4CGA, AFP
12dihydrotestosterone46 30 25 1212.4CGA, SRY, PTHLH
13agarose469.3INHA, SRY, KIT
14forskolin46 52 1211.3INHA, PTHLH, CGA
15cycloheximide469.2PTHLH, KIT, CGA
16androstenedione46 2510.2CGA, INHA
17vincristine46 52 1211.2KIT, PTHLH, AFP
18irinotecan46 52 1211.2KIT, AFP
19vinblastine46 52 1211.2AFP, CGA
20valine469.2AFP, PTHLH, KIT
21bleomycin46 1210.1AFP, PTHLH, CGA
22paclitaxel46 52 1211.1KIT, PTHLH, AFP
23glycogen46 2510.1KIT, PTHLH, AFP
24thyroxine46 2510.1CGA, PTHLH, AFP
25cyclophosphamide46 52 1211.1CGA, PTHLH, AFP
26cyclic amp46 2510.1CGA, PTHLH, INHA
27vitamin d469.1CGA, PTHLH, AFP
28thymidine46 2510.1KIT, PTHLH, AFP
29methotrexate52 46 1211.0CGA, KIT, AFP
30doxorubicin46 52 1211.0AFP, KIT, CGA
31cisplatin46 52 62 1212.0AFP, PTHLH, CGA
32creatinine469.0CGA, PTHLH, AFP
33heparin46 30 25 1211.9CGA, PTHLH, AFP
34hydrogen46 259.9INHA, AFP, PTHLH
35aspartate468.9AFP, KIT, CGA
36ribonucleic acid468.9CGA, KIT, PTHLH, INHA
37silver468.8SRY, AFP
38actinomycin d468.7AFP, PTHLH, KIT, CGA
39lactate468.7CGA, KIT, PTHLH, AFP
40vegf468.7AFP, PTHLH, KIT, CGA
41oligonucleotide468.4INHA, AFP, SRY, KIT
42serine468.2AFP, PTHLH, SRY, KIT, CGA
43paraffin468.1INHA, AFP, PTHLH, KIT, CGA
44progesterone46 30 62 25 1212.1CGA, KIT, PTHLH, AFP, INHA
45estrogen468.1INHA, AFP, PTHLH, KIT, CGA
46tyrosine468.1INHA, AFP, PTHLH, SRY, KIT
47estradiol46 25 1210.0INHA, AFP, PTHLH, SRY, CGA
48alanine468.0INHA, AFP, PTHLH, SRY, CGA
49testosterone46 62 25 1210.6CGA, KIT, SRY, PTHLH, AFP, INHA
50steroid467.6INHA, AFP, PTHLH, SRY, KIT, CGA

GO Terms for genes affiliated with Dysgerminoma

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17Gene Ontology
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Biological processes related to Dysgerminoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1erythrocyte differentiationGO:0302189.5KIT, INHA
2ovarian follicle developmentGO:0015419.5KIT, INHA
3positive regulation of cell migrationGO:0303359.5CGA, KIT
4male gonad developmentGO:0085849.4KIT, INHA
5regulation of cell proliferationGO:0421279.3KIT, INHA
6positive regulation of cell proliferationGO:0082849.2PTHLH, KIT, CGA
7skeletal system developmentGO:0015019.1PTHLH, INHA
8cell-cell signalingGO:0072679.1CGA, PTHLH, INHA

Molecular functions related to Dysgerminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.9CGA, PTHLH, INHA

Products for genes affiliated with Dysgerminoma

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  • Antibodies
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Sources for Dysgerminoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet