Summaries for Dysgerminoma

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Wikipedia:64 A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the ovary. more...

MalaCards based summary: Dysgerminoma is related to gonadoblastoma and hermaphroditism. An important gene associated with Dysgerminoma is PTHLH (parathyroid hormone-like hormone), and among its related pathways are G alpha (s) signalling events and Peptide hormone metabolism. The compounds ag-1296 and clodronate have been mentioned in the context of this disorder. Affiliated tissues include ovary, lymph node and lung, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Aliases & Classifications for Dysgerminoma

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Sources:
11DISEASES, 44Novoseek, 61UMLS
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Dysgerminoma, Aliases & Descriptions:

Name: Dysgerminoma 11 44 61


Related Diseases for Dysgerminoma

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Diseases related to Dysgerminoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma31.4KIT, SRY
2hermaphroditism30.8SRY
3turner syndrome30.5SRY, CGA
4teratoma30.2AFP, KIT, CGA
5androgen insensitivity syndrome30.1SRY, CGA
6endodermal sinus tumor30.1INHA, AFP
7seminoma30.0CGA, KIT, AFP, INHA
8sertoli-leydig cell tumor29.9INHA, AFP
9choriocarcinoma29.9CGA, AFP, INHA
10leydig cell tumor29.9INHA, PTHLH, CGA
11wilms tumor29.6SRY, INHA
12germinoma29.5CGA, KIT, AFP, INHA
13adenocarcinoma29.4INHA, AFP, PTHLH
14down syndrome29.2INHA, AFP, SRY, CGA
15gonadal dysgenesis10.6
16hypercalcemia10.4
17swyer syndrome10.4
18testicular disease10.4SRY
19epithelioid trophoblastic tumor10.4INHA
20sertoli cell tumor10.4INHA
21dysgerminoma of ovary10.3
22pediatric ovarian dysgerminoma10.3
23ovarian gonadoblastoma10.3
24oligohydramnios10.3AFP
25ataxia telangiectasia10.3
26ataxia10.3
27germ cell tumors10.3
28hyperprolactinemia10.2PTHLH, CGA
29luteoma10.2CGA, SRY
30endometrial stromal sarcoma10.2INHA, KIT
31placental site trophoblastic tumor10.2INHA, CGA
32frasier syndrome10.2
33pineal dysgerminoma10.2
34neuronitis10.2
35prolactinoma10.1CGA, PTHLH
36trophoblastic neoplasm10.1CGA, INHA
37hypospadias10.1CGA, SRY
38cryptorchidism10.1CGA, SRY
39aorta atresia10.1INHA, CGA
40pancreatic islet cell tumors10.1AFP, PTHLH
41male infertility10.1CGA, SRY
42abrikosov's tumor10.1CGA, INHA
43gestational trophoblastic neoplasm10.1INHA, CGA
44leiomyosarcoma10.1KIT, INHA
45hematologic cancer10.1PTHLH, KIT
46klinefelter's syndrome10.1INHA, CGA
47azoospermia10.1SRY, CGA
48neurilemmoma10.1INHA, KIT
49male germ cell tumor, somatic10.1AFP, CGA
50encephalitis10.1

Graphical network of the top 20 diseases related to Dysgerminoma:



Diseases related to dysgerminoma

Symptoms for Dysgerminoma

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Drugs & Therapeutics for Dysgerminoma

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Drug clinical trials:

Search ClinicalTrials for Dysgerminoma

Search NIH Clinical Center for Dysgerminoma

Genetic Tests for Dysgerminoma

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Anatomical Context for Dysgerminoma

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MalaCards organs/tissues related to Dysgerminoma:

32
Ovary, Lymph node, Lung, Breast, Uterus, Brain, Pancreas, Thyroid, Skin, Placenta, Testes, Cervix, Myeloid, T cells

Animal Models for Dysgerminoma or affiliated genes

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MGI Mouse Phenotypes related to Dysgerminoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6KIT, AFP, INHA
2MP:00053767.5INHA, AFP, PTHLH, KIT, CGA
3MP:00107687.3INHA, AFP, PTHLH, SRY, KIT
4MP:00053797.2CGA, KIT, SRY, PTHLH, AFP, INHA
5MP:00053897.1INHA, AFP, PTHLH, SRY, KIT, CGA

Publications for Dysgerminoma

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Articles related to Dysgerminoma:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
Anti-Ma-associated encephalitis due to dysgerminoma in a woman with Swyer syndrome. (24711536)
2014
2
Bilateral poorly differentiated Sertoli-Leydig ovarian tumor associated with dysgerminoma: case report. (24601056)
2013
3
Ovarian dysgerminoma in an adolescent: a case report. (24377208)
2013
4
Novel mutation of the sex-determining region on the Y chromosome in a 46,XY female patient with monolateral dysgerminoma: a case report. (22889418)
2013
5
Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report. (24179931)
2013
6
Bilateral dysgerminoma in a patient with a previous diagnosis of Swyer syndrome. (22176344)
2012
7
Ovarian dysgerminoma in two sisters. (23012179)
2008
8
46 XY pure gonadal dysgenesis with gonadoblastoma and dysgerminoma. (19472738)
2008
9
Medical image. A prepubescent mass. Swyer syndrome with a bilateral dysgerminoma. (18392069)
2008
10
Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis. (16554737)
2006
11
Gonadoblastoma with contralateral dysgerminoma in a young female--a case report. (16933739)
2006
12
Familial ovarian dysgerminomas (Swyer syndrome) in females associated with 46 XY-karyotype. (12012620)
2002
13
Dysgerminoma associated with hypercalcemia: A case report. (11431795)
2001
14
Pregnancy in a woman with a Y chromosome after removal of an ovarian dysgerminoma. (11104633)
2000
15
Advanced stage of dysgerminoma in testicular feminisation: is radical surgery necessary? (10925918)
2000
16
An unusual case of urinary incontinence, ataxia-telangiectasia, and metastatic dysgerminoma: case report and review of the literature. (9301718)
1997
17
Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46XX karyotype. (7789879)
1995
18
Accumulation of gamma/delta T cells in human dysgerminoma and seminoma: roles in autologous tumor killing and granuloma formation. (7622197)
1995
19
Ovarian dysgerminoma: color Doppler ultrasonographic findings and comparison with CT and MR imaging findings. (8551550)
1995
20
The association of ovarian dysgerminoma and gonadoblastoma in a phenotypic female with 46 XY karyotype. (8005142)
1994
21
Gonadoblastoma and dysgerminoma associated with 46,XY pure gonadal dysgenesis--a case report. (8305146)
1993
22
Dysgerminoma of the ovary. An immunohistochemical study of tumor-infiltrating lymphoreticular cells and tumor cells. (8453580)
1993
23
Characterization of the inflammatory infiltrate in ovarian dysgerminoma: an immunocytochemical study. (1607150)
1992
24
Fine-needle aspiration biopsy of seminoma and dysgerminoma: cytologic, histologic, and electron microscopic correlations. (2159868)
1990
25
Dysgerminoma: a study of 13 cases from the Connecticut Tumor Registry. (2743762)
1989
26
Neuron-specific enolase as a serum marker for immature teratoma and dysgerminoma. (2910781)
1989
27
Experimental endocrinotherapy with tamoxifen of human ovarian dysgerminoma transplanted into nude mice. (3429992)
1987
28
Human chorionic gonadotrophin producing ovarian dysgerminoma. (3665890)
1987
29
Urinary retention secondary to ovarian dysgerminoma in a girl. (4012986)
1985
30
Pure dysgerminoma of the ovary with elevated serum human chorionic gonadotropin: diagnostic and therapeutic considerations. (2579008)
1985
31
Conservative treatment of ovarian dysgerminoma with subsequent pregnancy. (6704293)
1984
32
Dysgerminoma with syncytiotrophoblastic giant cells presenting as a hydatidiform mole. (6745734)
1984
33
Association of dermatomyositis and dysgerminoma in a 16-year-old patient. (6838683)
1983
34
Gonadoblastoma and dysgerminoma with ataxia-telangiectasia. (990441)
1976
35
Bilateral gonadoblastoma with dysgerminoma. A case report. (5057796)
1972
36
Essential hypernatremia, absence of thirst, hypopituitarism, and hypothalamic destruction due to a dysgerminoma. (4679411)
1972
37
Bilateral metachronous dysgerminoma with a 15-year interval. (5574081)
1971
38
Hormone studies of an ovarian dysgerminoma. (5129555)
1971
39
Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. (5094323)
1971
40
Ovarian dysgerminoma. A survey and 12 cases. (5658174)
1968
41
Late results of treatment of ovarian dysgerminoma in the material of the Institute of Oncology in the years 1947-1959. (6006207)
1966
42
DYSGERMINOMA OF THE OVARY: A CLINICAL REPORT OF 20 CASES. (14248209)
1964
43
A case of retroperitoneal metastasis of dysgerminoma ovarii. (14010609)
1962
44
Dysgerminoma ovarii. (13069746)
1953
45
Dysgerminoma treated with nitrogen mustard. (14894566)
1952
46
Ovarian dysgerminoma. (18864048)
1948
47
Fertility and dysgerminoma ovarii. (18877067)
1948
48
Dysgerminoma ovarii. (20247858)
1947
49
Dysgerminoma of the ovary. (20288041)
1947
50
A Case of Ovarian Dysgerminoma. (19992879)
1944

Variations for Dysgerminoma

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Expression for genes affiliated with Dysgerminoma

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Expression patterns in normal tissues for genes affiliated with Dysgerminoma

Search GEO for disease gene expression data for Dysgerminoma.

Pathways for genes affiliated with Dysgerminoma

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Pathways related to Dysgerminoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CGA, PTHLH
2
Show member pathways
9.3CGA, INHA
39.1CGA, AFP

Compounds for genes affiliated with Dysgerminoma

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Compounds related to Dysgerminoma according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1ag-12964410.0KIT, PTHLH
2clodronate44 50 1211.9CGA, PTHLH
3cloprostenol44 2910.7CGA, INHA
43beta-hydroxysteroid449.6CGA, INHA
5oestriol449.6CGA, AFP
6dbc-amp449.5CGA, PTHLH
7hematoxylin449.5KIT, INHA
8clomiphene citrate449.5AFP, CGA
9ifosfamide44 1210.5CGA, AFP
10ccl444 2910.4AFP, PTHLH
11diethylstilbestrol44 29 1211.4CGA, AFP
12dihydrotestosterone44 29 25 1212.4CGA, SRY, PTHLH
13agarose449.3INHA, SRY, KIT
14forskolin44 50 1211.3INHA, PTHLH, CGA
15cycloheximide449.2PTHLH, KIT, CGA
16androstenedione44 2510.2CGA, INHA
17vincristine44 50 1211.2KIT, PTHLH, AFP
18irinotecan44 50 1211.2KIT, AFP
19vinblastine44 50 1211.2AFP, CGA
20valine449.2AFP, PTHLH, KIT
21bleomycin44 1210.1AFP, PTHLH, CGA
22paclitaxel44 50 1211.1KIT, PTHLH, AFP
23glycogen44 2510.1KIT, PTHLH, AFP
24thyroxine44 2510.1CGA, PTHLH, AFP
25cyclophosphamide44 50 1211.1CGA, PTHLH, AFP
26cyclic amp44 2510.1CGA, PTHLH, INHA
27vitamin d449.1CGA, PTHLH, AFP
28thymidine44 2510.1KIT, PTHLH, AFP
29methotrexate50 44 1211.0CGA, KIT, AFP
30doxorubicin44 50 1211.0AFP, KIT, CGA
31cisplatin44 50 60 1212.0AFP, PTHLH, CGA
32creatinine449.0CGA, PTHLH, AFP
33heparin44 29 25 1211.9CGA, PTHLH, AFP
34hydrogen44 259.9INHA, AFP, PTHLH
35aspartate448.9AFP, KIT, CGA
36ribonucleic acid448.9CGA, KIT, PTHLH, INHA
37silver448.8SRY, AFP
38actinomycin d448.7AFP, PTHLH, KIT, CGA
39lactate448.7CGA, KIT, PTHLH, AFP
40vegf448.7AFP, PTHLH, KIT, CGA
41oligonucleotide448.4INHA, AFP, SRY, KIT
42serine448.2AFP, PTHLH, SRY, KIT, CGA
43paraffin448.1INHA, AFP, PTHLH, KIT, CGA
44progesterone44 29 60 25 1212.1CGA, KIT, PTHLH, AFP, INHA
45estrogen448.1INHA, AFP, PTHLH, KIT, CGA
46tyrosine448.1INHA, AFP, PTHLH, SRY, KIT
47estradiol44 25 1210.0INHA, AFP, PTHLH, SRY, CGA
48alanine448.0INHA, AFP, PTHLH, SRY, CGA
49testosterone44 60 25 1210.6CGA, KIT, SRY, PTHLH, AFP, INHA
50steroid447.6INHA, AFP, PTHLH, SRY, KIT, CGA

GO Terms for genes affiliated with Dysgerminoma

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Biological processes related to Dysgerminoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1erythrocyte differentiationGO:0302189.5KIT, INHA
2ovarian follicle developmentGO:0015419.5KIT, INHA
3positive regulation of cell migrationGO:0303359.5CGA, KIT
4male gonad developmentGO:0085849.4KIT, INHA
5regulation of cell proliferationGO:0421279.3KIT, INHA
6positive regulation of cell proliferationGO:0082849.2PTHLH, KIT, CGA
7skeletal system developmentGO:0015019.1PTHLH, INHA
8cell-cell signalingGO:0072679.1CGA, PTHLH, INHA

Molecular functions related to Dysgerminoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051798.9CGA, PTHLH, INHA

Products for genes affiliated with Dysgerminoma

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Sources for Dysgerminoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet