MCID: DYS011
MIFTS: 39

Dyskinesia of Esophagus

Categories: Gastrointestinal diseases

Aliases & Classifications for Dyskinesia of Esophagus

MalaCards integrated aliases for Dyskinesia of Esophagus:

Name: Dyskinesia of Esophagus 12 14
Esophageal Motility Disorders 51 41 69
Esophageal Motility Disorder 12
Oesophageal Motor Disorder 12
Dyskinesia of Oesophagus 12
Oesophageal Dysmotility 12
Esophageal Dysmotility 12
Esophageal Spasm 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9192
ICD10 32 K22.4
ICD9CM 34 530.5
MeSH 41 D015154

Summaries for Dyskinesia of Esophagus

MalaCards based summary : Dyskinesia of Esophagus, also known as esophageal motility disorders, is related to crest syndrome and esophagitis, eosinophilic, 1, and has symptoms including spasm An important gene associated with Dyskinesia of Esophagus is TEF (TEF, PAR BZIP Transcription Factor). The drugs Dopamine and Pantoprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and bone.

Related Diseases for Dyskinesia of Esophagus

Diseases related to Dyskinesia of Esophagus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 crest syndrome 32.6 TOP1 UBTF
2 esophagitis, eosinophilic, 1 30.0 ATP12A ATP4A
3 esophagitis 10.4
4 fungal esophagitis 10.3 ATP12A ATP4A
5 bladder calculus 10.3 ATP12A ATP4A
6 gastrointestinal neuroendocrine benign tumor 10.3 ATP12A ATP4A
7 gastric neuroendocrine neoplasm 10.3 ATP12A ATP4A
8 neonatal candidiasis 10.3 ATP12A ATP4A
9 photoallergic dermatitis 10.3 ATP12A ATP4A
10 squamous papillomatosis 10.3 ATP12A ATP4A
11 acute laryngitis 10.3 ATP12A ATP4A
12 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
13 toxic megacolon 10.3 ATP12A ATP4A
14 aspiration pneumonitis 10.3 ATP12A ATP4A
15 esophageal candidiasis 10.3 ATP12A ATP4A
16 postsurgical hypothyroidism 10.3 ATP12A ATP4A
17 rumination disorder 10.3 ATP12A ATP4A
18 laryngeal disease 10.3 ATP12A ATP4A
19 duodenitis 10.3 ATP12A ATP4A
20 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
21 bile reflux 10.3 ATP12A ATP4A
22 granulomatous gastritis 10.3 ATP12A ATP4A
23 active peptic ulcer disease 10.3 ATP12A ATP4A
24 ischemic neuropathy 10.3 ATP12A ATP4A
25 anismus 10.3 ATP12A ATP4A
26 capillary disease 10.3 ATP12A ATP4A
27 peptic esophagitis 10.3 ATP12A ATP4A
28 duodenal disease 10.3 ATP12A ATP4A
29 hernia, hiatus 10.3 ATP12A ATP4A
30 laryngitis 10.3 ATP12A ATP4A
31 laryngeal tuberculosis 10.3 ATP12A ATP4A
32 lymphocytic colitis 10.3 ATP12A ATP4A
33 chronic intestinal vascular insufficiency 10.3 ATP12A ATP4A
34 clostridium difficile colitis 10.3 ATP12A ATP4A
35 lower urinary tract calculus 10.3 ATP12A ATP4A
36 diarrhea 1, secretory chloride, congenital 10.3 ATP12A ATP4A
37 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 ATP12A ATP4A
38 chronic laryngitis 10.3 ATP12A ATP4A
39 esophageal varix 10.2 ATP12A ATP4A
40 eosinophilic gastritis 10.2 ATP12A ATP4A
41 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A
42 esophagus adenocarcinoma 10.2 ATP12A ATP4A
43 jejunoileitis 10.2 ATP12A ATP4A
44 pancreatic steatorrhea 10.2 ATP12A ATP4A
45 superior mesenteric artery syndrome 10.2 ATP12A ATP4A
46 functional gastric disease 10.2 ATP12A ATP4A
47 lateral medullary syndrome 10.2 ATP12A ATP4A
48 paine syndrome 10.2 ATP12A ATP4A
49 cloacal exstrophy 10.1 ATP12A ATP4A
50 peptic ulcer perforation 10.1 ATP12A ATP4A

Comorbidity relations with Dyskinesia of Esophagus via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Anxiety
Bronchitis Chronic Myocardial Ischemia
Deficiency Anemia Dysthymic Disorder
Esophageal Disease Esophagitis
Gastroesophageal Reflux Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Irritable Bowel Syndrome
Ischemic Heart Disease Megaesophagus
Mitral Valve Disease Osteoporosis
Protein-Energy Malnutrition Swallowing Disorders

Graphical network of the top 20 diseases related to Dyskinesia of Esophagus:



Diseases related to Dyskinesia of Esophagus

Symptoms & Phenotypes for Dyskinesia of Esophagus

UMLS symptoms related to Dyskinesia of Esophagus:


spasm

Drugs & Therapeutics for Dyskinesia of Esophagus

Drugs for Dyskinesia of Esophagus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 264)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
2
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1 102625-70-7 4679
3
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
4
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 103577-45-3 3883
5
Rabeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 117976-89-3 5029
6
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 9579578 4594
7
Domperidone Approved, Investigational, Vet_approved Phase 4,Phase 3 57808-66-9 3151
8
Menthol Approved Phase 4,Phase 1,Phase 2 2216-51-5 16666
9
Methylene blue Approved, Investigational Phase 4 61-73-4
10
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 138530-94-6, 103577-45-3 9578005
11
Alginic acid Approved, Experimental, Investigational Phase 4,Phase 3,Phase 1 9005-32-7
12
Ethanol Approved Phase 4 64-17-5 702
13
Cimetidine Approved, Investigational Phase 4 51481-61-9 2756
14
Metoclopramide Approved, Investigational Phase 4,Phase 3 364-62-5 4168
15
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 51-45-6, 75614-87-8 774
16
Ranitidine Approved Phase 4,Phase 3,Phase 2 66357-59-3, 66357-35-5 3001055
17
Famotidine Approved Phase 4,Phase 2,Phase 3 76824-35-6 3325
18
Pectin Approved, Vet_approved Phase 4 9000-69-5 441476
19
Dronabinol Approved, Illicit Phase 4 1972-08-3 16078 2978
20
Nortriptyline Approved Phase 4,Phase 2,Phase 3 72-69-5 4543
21
Nizatidine Approved Phase 4,Phase 3 76963-41-2 3033637
22
Aluminum hydroxide Approved, Investigational Phase 4,Phase 3,Phase 1 21645-51-2
23
Magnesium Hydroxide Approved, Investigational Phase 4,Phase 1 1309-42-8
24 Magnesium trisilicate Approved Phase 4,Phase 3,Phase 1 14987-04-3
25
Trimebutine Approved Phase 4 39133-31-8
26
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
27
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
28
Clozapine Approved Phase 4 5786-21-0 2818
29
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
30
Ziprasidone Approved Phase 4 146939-27-7 60854
31
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
32
Asenapine Approved Phase 4 85650-56-2, 65576-45-6 3001386
33
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
34
Clarithromycin Approved Phase 4 81103-11-9 84029
35
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
36
Citalopram Approved Phase 4 59729-33-8 2771
37
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
38 Lafutidine Investigational Phase 4,Phase 3 118288-08-7
39 Rebamipide Investigational Phase 4 90098-04-7
40 Mosapride Investigational Phase 4 112885-41-3
41
Maleic acid Experimental Phase 4 110-16-7 444266
42 mometasone furoate Phase 4
43 Analgesics Phase 4
44 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
45 Cholinergic Agents Phase 4,Phase 2,Phase 1
46 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Coagulants Phase 4,Phase 3
48 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Hemostatics Phase 4,Phase 3
50 Anesthetics Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 745)

# Name Status NCT ID Phase Drugs
1 Personalized Peroral Endoscopic Myotomy for Achalasia Unknown status NCT01570621 Phase 4
2 Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity Unknown status NCT02140073 Phase 4 omeprazole+domperidone SR;omeprazole
3 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
4 Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance Unknown status NCT01503476 Phase 4
5 LGG for Prevention of Infectious Complications During PPI Treatment in Children Unknown status NCT01782118 Phase 4
6 Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and Sleep Disturbances Unknown status NCT02277886 Phase 4 sodium alginate;esomeprazole
7 Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy Unknown status NCT01328652 Phase 4 dexlansoprazole
8 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate Unknown status NCT02278081 Phase 4 lansoprazole;placebo
9 A Randomized, Double-Blind, Placebo-Controlled Study of Gastroesophageal Reflux Disease Therapy. Unknown status NCT00237068 Phase 4 Lansoprazole; Solutab
10 The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers Completed NCT02736734 Phase 4 CRH
11 The Effects of Cannabinoid on Patients With Non-GERD Related Non Cardiac Chest Pain Completed NCT01598207 Phase 4 Marinol;Placebo
12 Comparing Clinical Efficacy of One-Week Dual Delayed-Release Dexlansoprazole and Esomeprazole for GERD Grade A and B Completed NCT03128736 Phase 4 Esomeprazole group;Dexlansoprazole group
13 The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity Completed NCT02958046 Phase 4 Lansoprazole/Domperidone
14 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Completed NCT02689999 Phase 4 Dexrabeprazole 10 mg Enteric-Coated Tablets
15 Role of Pepsin Assay in Wheezy Infants Completed NCT02685436 Phase 4 Omeprazole and domperidone
16 Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease Completed NCT02351960 Phase 4 Dexlansoprazole
17 Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease. Completed NCT01601379 Phase 4
18 Safety and Efficacy of Lansoprazole in Patients With Reflux Disease Completed NCT01135368 Phase 4 Lansoprazole
19 Practice and Patient Compliance on the PPI (Proton Pump Inhibitors) Treatment of Gastroesophageal Reflux in South Korea Completed NCT01018160 Phase 4 Rabeprazole Sodium
20 A Study of Nexium (Esomeprazole) 40 mg Once Daily in Subjects With Symptoms of Gastroesophageal Reflux Disease (GORD) After Treatment With a Full Dose of Proton Pump Inhibitor (PPI) Completed NCT00734097 Phase 4 Esomeprazole 40 mg
21 Role of Mosapride in Patients With Gastroesophageal Reflux Disease Completed NCT00729339 Phase 4 mosapride for the first month and placebo for the 2nd month;placebo for the first and mosapride for the second month
22 Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US Completed NCT00660660 Phase 4 Esomeprazole;Placebo
23 Open, Randomized, Two Way Crossover 40mg, Orally and Intravenously Completed NCT00635414 Phase 4 Esomeprazole;Esomeprazole
24 An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Dise Completed NCT00629564 Phase 4 Esomeprazole;Esomeprazole
25 Open, Randomized, Two Way Crossover Study Comparing the Effect of Esomeprazole Adminstered Orally and iv Completed NCT00626262 Phase 4 Esomeprazole
26 Study Comparing the Effects of Esomeprazole Adminstered Orally and Intravenously on Basal and Pentrigastrin-stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD) Completed NCT00625495 Phase 4 Esomeprazole;Esomeprazole
27 Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients Completed NCT00574925 Phase 4 Esomeprazole
28 A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg Completed NCT00464308 Phase 4 Esomeprazole;Rabeprazole;Esomeprazole
29 Evaluation of 24-Hour Intragastric pH Using Esomeprazole, Lansoprazole, and Pantoprazole in Hispanic Patients With GERD Completed NCT00410592 Phase 4 Esomeprazole 40mg;Pantoprazole 40mg;Lansoprazole 30mg
30 Examine National Characteristics & Outcome Measures of GERD Patients Using the PPI Acid Suppression Symptom (PASS) Test for Response Completed NCT00392002 Phase 4 Esomeprazole
31 PPI Sequencing Study Completed NCT00384592 Phase 4 Esomeprazole
32 CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing Completed NCT00354757 Phase 4 rabeprazole
33 Symptom Adapted Therapy in GERD Patients Completed NCT00343161 Phase 4 esomeprazole;Gelusil-Lac (Aluminum hydroxide gel,magnesium trisilicate)
34 Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantoprazole in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) (BY1023/M3-342) Completed NCT00325676 Phase 4 Pantoprazole
35 Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD Completed NCT00304421 Phase 4 rabeprazole;pantoprazole
36 Validation of RDQ Questionnaire Completed NCT00291746 Phase 4 Esomeprazole
37 Esomeprazole in PPI Failures - IMPROVE Completed NCT00272701 Phase 4 Esomeprazole;Other PPI marketed in Sweden
38 Determination of a Questionnaire After Treatment With Pantoprazole at Full Dose and Half Dose in Adult Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/UK-506) Completed NCT00261339 Phase 4 Pantoprazole
39 Role of Pain Modulation in GERD Patients Who Failed Standard Dose Proton Pump Inhibitors (PPI) Completed NCT00251732 Phase 4 Standard dose (once daily) PPI plus low-dose antidepressant;Double dose PPI plus evening placebo;Rabeprazole , placebo, placebo
40 Determination of the Minimal Clinically Important Difference After Treatment With Pantoprazole in Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-340) Completed NCT00246909 Phase 4 Pantoprazole
41 An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 mg in Patients With Symptoms of Gastroesophageal Reflux Disease (GERD) Completed NCT00242736 Phase 4 Esomeprazole
42 On Demand Treatment of Reflux Disease Completed NCT00184522 Phase 4 Aflurax;esomeprazole
43 Esomeprazole for Treatment of GERD in Pediatric Patients Completed NCT00228527 Phase 4 Esomeprazole (Nexium)
44 Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation Completed NCT03116841 Phase 4 Vonoprazan
45 Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis Completed NCT03086070 Phase 4 Omeprazole 20mg;Placebo oral capsule
46 A Study to Evaluate REbamiPide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis Completed NCT02755753 Phase 4 Lansoprazole;Rebamipide;Rebamipide-placebo
47 To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole Completed NCT01397084 Phase 4 esomeprazole 20 mg
48 An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis Completed NCT01008696 Phase 4 Rabeprazole;Lansoprazole
49 Hypoallergenic Infant Formula Containing Starch and the Probiotic: Effect on Gastric Emptying Completed NCT01956682 Phase 4
50 The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia Completed NCT00926276 Phase 4

Search NIH Clinical Center for Dyskinesia of Esophagus

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: esophageal motility disorders

Genetic Tests for Dyskinesia of Esophagus

Anatomical Context for Dyskinesia of Esophagus

MalaCards organs/tissues related to Dyskinesia of Esophagus:

38
Testes, Lung, Bone, Tongue, Tonsil, Thyroid, Adipocyte

Publications for Dyskinesia of Esophagus

Articles related to Dyskinesia of Esophagus:

# Title Authors Year
1
Esophageal motility disorder achalasia. ( 24136218 )
2013
2
Botulinum toxin reduces Dysphagia in patients with nonachalasia primary esophageal motility disorders. ( 23591282 )
2013
3
The hidden cause of dysphagia--epiphrenic diverticulum and esophageal motility disorders. ( 22312603 )
2012
4
A stepwise approach and early clinical experience in peroral endoscopic myotomy for the treatment of achalasia and esophageal motility disorders. ( 21996484 )
2011
5
Achalasia and other esophageal motility disorders. ( 21394546 )
2011
6
Primary localized cutaneous nodular amyloidosis associated with CREST (calcinosis, Raynaud's phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome. ( 20465653 )
2010
7
Nonspecific esophageal motility disorders may be an early stage of a specific disorder, particularly achalasia. ( 19302217 )
2009
8
Radionuclide imaging for the assessment of esophageal motility disorders in mixed connective tissue disease patients: relation to pulmonary impairment. ( 16984539 )
2006

Variations for Dyskinesia of Esophagus

Expression for Dyskinesia of Esophagus

Search GEO for disease gene expression data for Dyskinesia of Esophagus.

Pathways for Dyskinesia of Esophagus

GO Terms for Dyskinesia of Esophagus

Biological processes related to Dyskinesia of Esophagus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proton transport GO:0015992 8.96 ATP12A ATP4A
2 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Dyskinesia of Esophagus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Dyskinesia of Esophagus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....