MCID: DYS011
MIFTS: 27

Dyskinesia of Esophagus malady

Gastrointestinal diseases category
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Summaries for Dyskinesia of Esophagus

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33MalaCards
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MalaCards: Dyskinesia of Esophagus, also known as esophageal motility disorders, is related to esophagitis and achalasia. An important gene associated with Dyskinesia of Esophagus is ATP4A (ATPase, H+/K+ exchanging, alpha polypeptide), and among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds pantoprazole and Phosphate have been mentioned in the context of this disorder. Related mouse phenotype digestive/alimentary.

Aliases & Classifications for Dyskinesia of Esophagus

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

dyskinesia of esophagus 8 10
esophageal motility disorders 45 62
esophageal motility disorder 8
oesophageal motor disorder 8
dyskinesia of oesophagus 8
oesophageal dysmotility 8
esophageal dysmotility 8


External Ids:

Disease Ontology8 DOID:9192
ICD9CM27 530.5
MeSH35 D015154
ICD1025 K22.4

Related Diseases for Dyskinesia of Esophagus

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Dyskinesia of Esophagus:



Diseases related to dyskinesia of esophagus

Symptoms for Dyskinesia of Esophagus

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Drugs & Therapeutics for Dyskinesia of Esophagus

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Dyskinesia of Esophagus

Search NIH Clinical Center for Dyskinesia of Esophagus

Genetic Tests for Dyskinesia of Esophagus

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Anatomical Context for Dyskinesia of Esophagus

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Animal Models for Dyskinesia of Esophagus or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Dyskinesia of Esophagus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.1ATP12A, ATP4A

Publications for Dyskinesia of Esophagus

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Variations for Dyskinesia of Esophagus

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Expression for genes affiliated with Dyskinesia of Esophagus

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Dyskinesia of Esophagus

Search GEO for disease gene expression data for Dyskinesia of Esophagus.

Pathways for genes affiliated with Dyskinesia of Esophagus

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Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Dyskinesia of Esophagus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ATP12A, ATP4A
2
Show member pathways
9.1ATP12A, ATP4A
3
Show member pathways
9.1ATP12A, ATP4A
4
Show member pathways
calcium transport I38
9.1ATP12A, ATP4A

Compounds for genes affiliated with Dyskinesia of Esophagus

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Sources:
45Novoseek, 51PharmGKB, 24HMDB, 11DrugBank, 29IUPHAR
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Compounds related to Dyskinesia of Esophagus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pantoprazole45 51 24 1112.2ATP12A, ATP4A
2Phosphate249.2ATP12A, ATP4A
3potassium45 24 1111.1ATP12A, ATP4A
4Adenosine triphosphate24 1110.1ATP12A, ATP4A
5Water249.0ATP4A, ATP12A
6adp45 29 2410.8ATP12A, ATP4A

GO Terms for genes affiliated with Dyskinesia of Esophagus

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Sources:
16Gene Ontology
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Biological processes related to Dyskinesia of Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane transportGO:0550859.1ATP12A, ATP4A
2ATP biosynthetic processGO:0067549.0ATP12A, ATP4A
3ion transmembrane transportGO:0342208.8ATP12A, ATP4A

Molecular functions related to Dyskinesia of Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hydrogen:potassium-exchanging ATPase activityGO:0089009.1ATP12A, ATP4A

Products for genes affiliated with Dyskinesia of Esophagus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Dyskinesia of Esophagus

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet